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Reconstructing Genomes Of Carbon Monoxide Oxidisers In Volcanic Deposits Including Members Of The Class Ktedonobacteria, Marcela Hernández, Blanca Vera-Gargallo, Marcela Calabi-Floody, Gary M. King, Ralf Conrad, Christoph C. Tebbe Dec 2020

Reconstructing Genomes Of Carbon Monoxide Oxidisers In Volcanic Deposits Including Members Of The Class Ktedonobacteria, Marcela Hernández, Blanca Vera-Gargallo, Marcela Calabi-Floody, Gary M. King, Ralf Conrad, Christoph C. Tebbe

Faculty Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Microorganisms can potentially colonise volcanic rocks using the chemical energy in reduced gases such as methane, hydrogen (H2) and carbon monoxide (CO). In this study, we analysed soil metagenomes from Chilean volcanic soils, representing three different successional stages with ages of 380, 269 and 63 years, respectively. A total of 19 metagenome-assembled genomes (MAGs) were retrieved from all stages with a higher number observed in the youngest soil (1640: 2 MAGs, 1751: 1 MAG, 1957: 16 MAGs). Genomic similarity indices showed that several MAGs had amino-acid identity (AAI) values >50% to …

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Comparison Of Conventional And Advanced Radiotherapy Techniques For Left-Sided Breast Cancer After Breast Conserving Surgery, Yibo Xie, Daniel Bourgeois, Beibei Guo, Rui Zhang Dec 2020

Comparison Of Conventional And Advanced Radiotherapy Techniques For Left-Sided Breast Cancer After Breast Conserving Surgery, Yibo Xie, Daniel Bourgeois, Beibei Guo, Rui Zhang

Faculty Publications

Whole breast radiotherapy (WBRT) after breast conserving surgery is the standard treatment to prevent recurrence and metastasis of early stage breast cancer. This study aims to compare seven WBRT techniques including conventional tangential, field-in-field (FIF), hybrid intensity-modulated radiotherapy (IMRT), IMRT, standard volumetric modulated arc therapy (STD-VMAT), noncoplanar VMAT (NC-VMAT), and multiple arc VMAT (MA-VMAT). Fifteen patients who were previously diagnosed with left-sided early stage breast cancer and treated in our clinic were selected for this study. WBRT plans were created for these patients and were evaluated based on target coverage and normal tissue toxicities. All techniques produced clinically acceptable WBRT …

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Mobilization Of Iron Stored In Bacterioferritin Is Required For Metabolic Homeostasis In Pseudomonas Aeruginosa, Achala N.D. Punchi Hewage, Leo Fontenot, Jessie Guidry, Thomas Weldeghiorghis, Anil K. Mehta, Fabrizio Donnarumma, Mario Rivera Dec 2020

Mobilization Of Iron Stored In Bacterioferritin Is Required For Metabolic Homeostasis In Pseudomonas Aeruginosa, Achala N.D. Punchi Hewage, Leo Fontenot, Jessie Guidry, Thomas Weldeghiorghis, Anil K. Mehta, Fabrizio Donnarumma, Mario Rivera

Faculty Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Iron homeostasis offers a significant bacterial vulnerability because pathogens obtain essential iron from their mammalian hosts, but host-defenses maintain vanishingly low levels of free iron. Although pathogens have evolved mechanisms to procure host-iron, these depend on well-regulated iron homeostasis. To disrupt iron homeostasis, our work has targeted iron mobilization from the iron storage protein bacterioferritin (BfrB) by blocking a required interaction with its cognate ferredoxin partner (Bfd). The blockade of the BfrB–Bfd complex by deletion of the bfd gene (∆bfd) causes iron to irreversibly accumulate in BfrB. In this study we …

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Biological Control Agent Attack Timing And Population Variability, But Not Density, Best Explain Target Weed Density Across An Environmental Gradient, Nathan Harms, James Cronin Dec 2020

Biological Control Agent Attack Timing And Population Variability, But Not Density, Best Explain Target Weed Density Across An Environmental Gradient, Nathan Harms, James Cronin

Faculty Publications

© 2020, The Author(s). Spatial variation in plant–herbivore interactions can be important in pest systems, particularly when insect herbivores are used as biological control agents to manage invasive plants. The geographic ranges of the invasive plant alligatorweed (Alternanthera philoxeroides) and its biological control agent the alligatorweed flea beetle (Agasicles hygrophila) do not completely overlap in the southeastern USA, producing spatial heterogeneity in interaction strength that may be related to latitude-correlated environmental gradients. We studied this system near the range margin of the alligatorweed flea beetle to test whether spatial variation in alligatorweed density was best explained by agent mean or …

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The Effect Of Summer Drought On The Predictability Of Local Extinctions In A Butterfly Metapopulation, Erik Van Bergen, Tad Dallas, Michelle F. Dileo, Aapo Kahilainen, Anniina L.K. Mattila, Miska Luoto, Marjo Saastamoinen Dec 2020

The Effect Of Summer Drought On The Predictability Of Local Extinctions In A Butterfly Metapopulation, Erik Van Bergen, Tad Dallas, Michelle F. Dileo, Aapo Kahilainen, Anniina L.K. Mattila, Miska Luoto, Marjo Saastamoinen

Faculty Publications

© 2020 The Authors. Conservation Biology published by Wiley Periodicals LLC on behalf of Society for Conservation Biology The ecological impacts of extreme climatic events on population dynamics and community composition are profound and predominantly negative. Using extensive data of an ecological model system, we tested whether predictions from ecological models remain robust when environmental conditions are outside the bounds of observation. We observed a 10-fold demographic decline of the Glanville fritillary butterfly (Melitaea cinxia) metapopulation on the Åland islands, Finland in the summer of 2018 and used climatic and satellite data to demonstrate that this year was an anomaly …

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Development Of A Degree-Day Model To Predict Egg Hatch Of Aedes Albopictus, Kristen B. Healy, Emily Dugas, Dina M. Fonseca Dec 2020

Development Of A Degree-Day Model To Predict Egg Hatch Of Aedes Albopictus, Kristen B. Healy, Emily Dugas, Dina M. Fonseca

Faculty Publications

Aedes albopictus, the Asian tiger mosquito, is an important nuisance mosquito species and known vector of arboviruses such as dengue, chikungunya, and Zika. Despite their cosmopolitan distribution around the world, there is a paucity of accurate predictive models based on rates of development at different temperatures (degree-day models). These types of models can benefit mosquito control districts by predicting when to target early-season larval development, when populations are likely at their lowest levels. In this study, we determined the effect of temperature and nutrient levels on the development rates and male and female adult size of 2 Ae. albopictus populations: …

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Colletotrichum Truncatum Causing Anthracnose On Papaya Fruit (Carica Papaya) In Brazil, Willie Anderson Dos Santos Vieria, Angélica Dos Santos Nunes, Josiene Silva Veloso, Alexandre Reis Machado, Valdir Queiroz Balbino, Anthony Carlos Da Silva, André Ângelo Medeiros Gomes, Vinson Patrick Doyle, Marcos Paz Saraiva Câmara Dec 2020

Colletotrichum Truncatum Causing Anthracnose On Papaya Fruit (Carica Papaya) In Brazil, Willie Anderson Dos Santos Vieria, Angélica Dos Santos Nunes, Josiene Silva Veloso, Alexandre Reis Machado, Valdir Queiroz Balbino, Anthony Carlos Da Silva, André Ângelo Medeiros Gomes, Vinson Patrick Doyle, Marcos Paz Saraiva Câmara

Faculty Publications

Papaya anthracnose caused by Colletotrichum truncatum is reported for the first time in Brazil. The etiological agent was identified by a combination of morphological and molecular approaches. Pathogenicity was confirmed and Koch’s postulates fulfilled for a selected isolate from Porto Seguro, Bahia, Brazil.

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Two Hundred And Fifty-Four Metagenome-Assembled Bacterial Genomes From The Bank Vole Gut Microbiota, Anton Lavrinienko, Eugene Tukalenko, Timothy A. Mousseau, Luke R. Thompson, Rob Knight, Tapio Mappes, Phillip C. Watts Dec 2020

Two Hundred And Fifty-Four Metagenome-Assembled Bacterial Genomes From The Bank Vole Gut Microbiota, Anton Lavrinienko, Eugene Tukalenko, Timothy A. Mousseau, Luke R. Thompson, Rob Knight, Tapio Mappes, Phillip C. Watts

Faculty Publications

Vertebrate gut microbiota provide many essential services to their host. To better understand the diversity of such services provided by gut microbiota in wild rodents, we assembled metagenome shotgun sequence data from a small mammal, the bank vole Myodes glareolus (Rodentia, Cricetidae). We were able to identify 254 metagenome assembled genomes (MAGs) that were at least 50% (n = 133 MAGs), 80% (n = 77 MAGs) or 95% (n = 44 MAGs) complete. As typical for a rodent gut microbiota, these MAGs are dominated by taxa assigned to the phyla Bacteroidetes (n = 132 MAGs) and …

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Genetic Determinants For Agronomic And Yield-Related Traits Localized On A Gbs-Snp Linkage Map From A Japonica X Indica Cross In Rice, Teresa B. De Leon, Rajat Pruthi, Babitha Jampala, Anna H. Borjas, Prasanta K. Subudhi Dec 2020

Genetic Determinants For Agronomic And Yield-Related Traits Localized On A Gbs-Snp Linkage Map From A Japonica X Indica Cross In Rice, Teresa B. De Leon, Rajat Pruthi, Babitha Jampala, Anna H. Borjas, Prasanta K. Subudhi

Faculty Publications

Rice is an important cereal for human consumption. Identification of QTLs for important agronomic traits with high resolution is essential to the identification of genes and marker-assisted breeding to improve rice productivity. A genotyping by sequencing (GBS)-based high-resolution SNP linkage developed in a recombinant inbred lines (RIL) population of a japonica (Bengal) × indica (Pokkali) cross was used for QTL analysis of traits such as days to heading, plant height, panicle length, flag leaf length, 1000 kernel weight, number of unfilled grains, number of filled grains, grain width, grain length, and awns using interval mapping and inclusive composite interval mapping …

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Influence Of Energy Removal Rate On The Quality Of Minced Meat From Undersized Crawfish During Frozen Storage, Franklin Bonilla, Vondel Reyes, Alexander Chouljenko, Bennett Dzandu, Subramaniam Sathivel Dec 2020

Influence Of Energy Removal Rate On The Quality Of Minced Meat From Undersized Crawfish During Frozen Storage, Franklin Bonilla, Vondel Reyes, Alexander Chouljenko, Bennett Dzandu, Subramaniam Sathivel

Faculty Publications

Abstract: Undersized crawfish have little economic value and are often discarded. Producing crawfish minced meat (CMM) from undersized crawfish and using an appropriate freezing technique may enable an economically viable market. The objective of this research was to evaluate the effect of the energy removal rate using two techniques, cryogenic freezing (CF) and air blast freezing (BF), on CMM’s quality during frozen storage. CMM was separated into two batches; one batch was cryogenically frozen with liquid nitrogen and the other batch was frozen with an air blast freezer. CMM batches were frozen and stored at − 18 °C. They were …

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Muscadine Or Amla Extracts Standardized To Ellagic Acid Content Ameliorate Glucolipotoxicity Associated Β-Cell Dysfunction Via Inhibition Of Il-1Β And Improved Insulin Secretion, Srikanth Earpina, Karen Mcdonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso Dec 2020

Muscadine Or Amla Extracts Standardized To Ellagic Acid Content Ameliorate Glucolipotoxicity Associated Β-Cell Dysfunction Via Inhibition Of Il-1Β And Improved Insulin Secretion, Srikanth Earpina, Karen Mcdonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso

Faculty Publications

Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined the effect of ellagic acid, ellagic acid-rich muscadine or amla extract, or urolothin A on inflammation in β cells under glucolipotoxic conditions. Rat NIT-1 β cells were incubated in glucolipotoxic conditions (33.3 mM glucose, 250 μM palmitic acid or 33.3 mM glucose + 250 μM palmitic acid with or without ellagic acid, ellagic acid-rich muscadine or amla extracts standardized to its ellagic acid content, …

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Monitoring 2019 Bonnet Carré Spillway Impacts - Final Report, J. Read Hendon, Jerry D. Wiggert, Jill Hendon Dec 2020

Monitoring 2019 Bonnet Carré Spillway Impacts - Final Report, J. Read Hendon, Jerry D. Wiggert, Jill Hendon

Faculty Publications

Due to the multiple and extended openings of the Bonnet Carré Spillway in 2019, the University of Southern Mississippi (USM) was tasked by the Mississippi Department of Marine Resources to conduct ecological sampling in the Mississippi Sound and adjacent waters. in an effort to better understand the impacts of the extensive freshwater diversion of Bonnet Carré Spillway operations on Mississippi's coastal and marine resources. The period of performance for this project was June 1, 2019, to August 31, 2019. This technical report summarizes the three months of weekly surveys and analyses, over June - August 2019, conducted by the University …

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Structure–Activity Relationship-Based Chemical Classification Of Highly Imbalanced Tox21 Datasets, Gabriel Idakwo, Sundar Thangapandian, Joseph Luttrell, Yan Li, Nan Wang, Zhaoxian Zhou, Huixiao Hong, Bei Yang, Chaoyang Zhang, Ping Gong Dec 2020

Structure–Activity Relationship-Based Chemical Classification Of Highly Imbalanced Tox21 Datasets, Gabriel Idakwo, Sundar Thangapandian, Joseph Luttrell, Yan Li, Nan Wang, Zhaoxian Zhou, Huixiao Hong, Bei Yang, Chaoyang Zhang, Ping Gong

Faculty Publications

The specificity of toxicant-target biomolecule interactions lends to the very imbalanced nature of many toxicity datasets, causing poor performance in Structure–Activity Relationship (SAR)-based chemical classification. Undersampling and oversampling are representative techniques for handling such an imbalance challenge. However, removing inactive chemical compound instances from the majority class using an undersampling technique can result in information loss, whereas increasing active toxicant instances in the minority class by interpolation tends to introduce artificial minority instances that often cross into the majority class space, giving rise to class overlapping and a higher false prediction rate. In this study, in order to improve the …

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The Effect Of Summer Drought On The Predictability Of Local Extinctions In A Butterfly Metapopulation, Erik Van Bergen, Tad Dallas, Michelle F. Dileo, Aapo Kahilainen, Anniina L.K. Mattila, Miska Luoto, Marjo Saastamoinen Dec 2020

The Effect Of Summer Drought On The Predictability Of Local Extinctions In A Butterfly Metapopulation, Erik Van Bergen, Tad Dallas, Michelle F. Dileo, Aapo Kahilainen, Anniina L.K. Mattila, Miska Luoto, Marjo Saastamoinen

Faculty Publications

The ecological impacts of extreme climatic events on population dynamics and community composition are profound and predominantly negative. Using extensive data of an ecological model system, we tested whether predictions from ecological models remain robust when environmental conditions are outside the bounds of observation. We observed a 10-fold demographic decline of the Glanville fritillary butterfly (Melitaea cinxia) metapopulation on the Åland islands, Finland in the summer of 2018 and used climatic and satellite data to demonstrate that this year was an anomaly with low climatic water balance values and low vegetation productivity indices across Åland. Population growth rates …

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Dystonia 16 (Dyt16) Mutations In Pact Cause Dysregulated Pkr Activation And Eif2Α Signaling Leading To A Compromised Stress Response, Samuel B. Burnett, Lauren S. Vaughn, Nutan Sharma, Ronit Kulkarni, Rekha C. Patel Dec 2020

Dystonia 16 (Dyt16) Mutations In Pact Cause Dysregulated Pkr Activation And Eif2Α Signaling Leading To A Compromised Stress Response, Samuel B. Burnett, Lauren S. Vaughn, Nutan Sharma, Ronit Kulkarni, Rekha C. Patel

Faculty Publications

Dystonia 16 (DYT16) is caused by mutations in PACT, the protein activator of interferon-induced double-stranded RNA-activated protein kinase (PKR). PKR regulates the integrated stress response (ISR) via phosphorylation of the translation initiation factor eIF2α. This post-translational modification attenuates general protein synthesis while concomitantly triggering enhanced translation of a few specific transcripts leading either to recovery and homeostasis or cellular apoptosis depending on the intensity and duration of stress signals. PKR plays a regulatory role in determining the cellular response to viral infections, oxidative stress, endoplasmic reticulum (ER) stress, and growth factor deprivation. In the absence of stress, both PACT and …

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Associative Nitrogen Fixation Linked With Three Perennial Bioenergy Grasses In Field And Greenhouse Experiments, Jayani J. Wewalwela, Yuan Tian, Janet R. Donaldson, Brian S. Baldwin, Jac J. Varco, Brett Rushing, Haoliang Lu, Mark A. Williams Dec 2020

Associative Nitrogen Fixation Linked With Three Perennial Bioenergy Grasses In Field And Greenhouse Experiments, Jayani J. Wewalwela, Yuan Tian, Janet R. Donaldson, Brian S. Baldwin, Jac J. Varco, Brett Rushing, Haoliang Lu, Mark A. Williams

Faculty Publications

© 2020 The Authors. Associative nitrogen (N2)‐fixation (ANF) by bacteria in the root‐zone of perennial bioenergy grasses has the potential to replace or supplement N fertilizer and support sustainable production of biomass, but its application in marginal ecosystems requires further evaluation. In this study, we first combined both greenhouse and field experiments, to explore the N2 fixation effects of three temperate feedstocks Miscanthus × giganteus (giant miscanthus, Freedom), Panicum virgatum (switchgrass, Alamo), and Saccharum sp. (energycane, Ho 02‐147). In field studies across three growing seasons, plant and soil pools of candidate feedstocks were partially composed of N …

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The Roles Of Osteopontin In The Pathogenesis Of West Nile Encephalitis, Farzana Nazneen, Fengwei Bai Dec 2020

The Roles Of Osteopontin In The Pathogenesis Of West Nile Encephalitis, Farzana Nazneen, Fengwei Bai

Faculty Publications

Osteopontin (OPN), a multifunctional protein encoded by the secreted phosphoprotein-1 (Spp-1) gene in humans, plays important roles in a variety of physiological conditions, such as biomineralization, bone remodeling and immune functions. OPN also has significant roles in the pathogenesis of autoimmune, allergy and inflammatory diseases, as well as bacterial, fungal and viral infections. West Nile virus (WNV), a mosquito-transmitted flavivirus, is the leading agent for viral encephalitis in North America. Recent progress has been made in understanding both the biological functions of OPN and the pathogenesis of WNV. In this review article, we have summarized the current understanding of the …

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The Role Of The Msaabcr Operon In Implant-Associated Chronic Osteomyelitis In Staphylococcus Aureus Usa300 Lac, Gyan S. Sahukhal, Michelle Tucci, Hamed Benghuzzi, Gerri Wilson, Mohamed O. Elasri Dec 2020

The Role Of The Msaabcr Operon In Implant-Associated Chronic Osteomyelitis In Staphylococcus Aureus Usa300 Lac, Gyan S. Sahukhal, Michelle Tucci, Hamed Benghuzzi, Gerri Wilson, Mohamed O. Elasri

Faculty Publications

The msaABCR operon regulates several staphylococcal phenotypes such as biofilm formation, capsule production, protease production, pigmentation, antibiotic resistance, and persister cells formation. The msaABCR operon is required for maintaining the cell wall integrity via affecting peptidoglycan cross-linking. The msaABCR operon also plays a role in oxidative stress defense mechanism, which is required to facilitate persistent and recurrent staphylococcal infections. Staphylococcus aureus is the most frequent cause of chronic implant-associated osteomyelitis (OM). The CA-MRSA USA300 strains are predominant in the United States and cause severe infections, including bone and joint infections.

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Homotopy Simulation Of Dissipative Micropolar Flow And Heat Transfer From A Two-Dimensional Body With Heat Sink Effect: Applications In Polymer Coating, O. A. Bég, B. Vasu, A. K. Ray, T. A. Beg, A. Kadir, H. J. Leonard, Rama S. R. Gorla Dec 2020

Homotopy Simulation Of Dissipative Micropolar Flow And Heat Transfer From A Two-Dimensional Body With Heat Sink Effect: Applications In Polymer Coating, O. A. Bég, B. Vasu, A. K. Ray, T. A. Beg, A. Kadir, H. J. Leonard, Rama S. R. Gorla

Faculty Publications

Non-Newtonian flow from a wedge constitutes a fundamental problem in chemical engineering systems and is relevant to processing of polymers, coating systems, etc. Motivated by such applications, the homotopy analysis method (HAM) was employed to obtain semi-analytical solutions for thermal convection boundary layer flow of incompressible micropolar fluid from a two-dimensional body (wedge). Viscous dissipation and heat sink effects were included. The non-dimensional boundary value problem emerges as a system of nonlinear coupled ordinary differential equations, by virtue of suitable coordinate transformations. The so-called Falkner-Skan flow cases are elaborated. Validation of the HAM solutions was achieved with earlier simpler models, …

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Biochemical And Genetic Analysis Of Ecm14, A Conserved Fungal Pseudopeptidase, R. Christian Mcdonald, Matthew James Schott, Temitope A. Idowu, Peter J. Lyons Dec 2020

Biochemical And Genetic Analysis Of Ecm14, A Conserved Fungal Pseudopeptidase, R. Christian Mcdonald, Matthew James Schott, Temitope A. Idowu, Peter J. Lyons

Faculty Publications

© 2020, The Author(s). Background: Like most major enzyme families, the M14 family of metallocarboxypeptidases (MCPs) contains a number of pseudoenzymes predicted to lack enzyme activity and with poorly characterized molecular function. The genome of the yeast Saccharomyces cerevisiae encodes one member of the M14 MCP family, a pseudoenzyme named Ecm14 proposed to function in the extracellular matrix. In order to better understand the function of such pseudoenzymes, we studied the structure and function of Ecm14 in S. cerevisiae. Results: A phylogenetic analysis of Ecm14 in fungi found it to be conserved throughout the ascomycete phylum, with a group of …

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Chloramination Of Iopamidol- And Bromide-Spiked Waters Containing Natural Organic Matter, Nana Osei B Ackerson, Hannah K. Liberatore, Susan D. Richardson, Micheal J. Plewa, Thomas A. Ternes, Stephen E. Duirk Nov 2020

Chloramination Of Iopamidol- And Bromide-Spiked Waters Containing Natural Organic Matter, Nana Osei B Ackerson, Hannah K. Liberatore, Susan D. Richardson, Micheal J. Plewa, Thomas A. Ternes, Stephen E. Duirk

Faculty Publications

Iopamidol (an iodinated X-ray contrast medium) and bromide are precursors in the formation of halogenated disinfection byproducts (DBPs). The interactions of these precursors are vital to elucidate the formation of halogenated DBPs during chloramination. This work investigated the formation of total organic halogen and select individual DBPs in two laboratory-chloraminated source waters containing iopamidol and bromide. Experiments were carried out in batch reactors containing Barberton source water (BSW) and Cleveland BSW (CSW), spiked with iopamidol (5 mu M), bromide (15 mu M), and 100 mu M monochloramine. Total organic iodine concentrations were approximately equal regardless of source water since they …

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Rumen And Serum Metabolomes In Response To Endophyte-Infected Tall Fescue Seed And Isoflavone Supplementation In Beef Steers, Taylor B. Ault-Seay, Emily A. Melchior-Tiffany, Brooke A. Clemmons Nov 2020

Rumen And Serum Metabolomes In Response To Endophyte-Infected Tall Fescue Seed And Isoflavone Supplementation In Beef Steers, Taylor B. Ault-Seay, Emily A. Melchior-Tiffany, Brooke A. Clemmons

Faculty Publications

Fescue toxicosis impacts beef cattle production via reductions in weight gain and muscle development. Isoflavone supplementation has displayed potential for mitigating these e ects. The objective of the current study was to evaluate isoflavone supplementation with fescue seed consumption on rumen and serum metabolomes. Angus steers (n = 36) were allocated randomly in a 2 2factorial arrangement of treatments including endophyte-infected (E+) or endophyte-free (E ) tall fescue seed, with (P+) or without (P ) isoflavones. Steers were provided a basal diet with fescue seed for 21 days, while isoflavones were orally administered daily. Following the trial, blood and rumen …

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Ideas And Perspectives: A Strategic Assessment Of Methane And Nitrous Oxide Measurements In The Marine Environment, Samuel T. Wilson, Alia N. Al-Haj, Annie Bourbonnais, Claudia Frey, Robinson W. Fulweiler, John D. Kessler, Hannah K. Marchant, Jana Milucka, Nicholas E. Ray, Parv Suntharalingham, Brett F. Thornton, Robert C. Upstill-Goddard, Thomas S. Weber, Damian L. Arévalo-Martínez, Hermann W. Bange, Heather M. Benway, Daniele Bianchi, Alberto V. Borges, Bonnie X. Chang, Patrick M. Crill, Daniela A. Del Valle, Laura Fariás, Samantha B. Joye, Annette Kock, Jabrane Labidi, Cara C. Manning, John W. Pohlman, Gregor Rehder, Katy J. Sparrow, Philippe D. Tortell, Tina Treude, David L. Valentine Nov 2020

Ideas And Perspectives: A Strategic Assessment Of Methane And Nitrous Oxide Measurements In The Marine Environment, Samuel T. Wilson, Alia N. Al-Haj, Annie Bourbonnais, Claudia Frey, Robinson W. Fulweiler, John D. Kessler, Hannah K. Marchant, Jana Milucka, Nicholas E. Ray, Parv Suntharalingham, Brett F. Thornton, Robert C. Upstill-Goddard, Thomas S. Weber, Damian L. Arévalo-Martínez, Hermann W. Bange, Heather M. Benway, Daniele Bianchi, Alberto V. Borges, Bonnie X. Chang, Patrick M. Crill, Daniela A. Del Valle, Laura Fariás, Samantha B. Joye, Annette Kock, Jabrane Labidi, Cara C. Manning, John W. Pohlman, Gregor Rehder, Katy J. Sparrow, Philippe D. Tortell, Tina Treude, David L. Valentine

Faculty Publications

In the current era of rapid climate change, accurate characterization of climate-relevant gas dynamics-namely production, consumption, and net emissions-is required for all biomes, especially those ecosystems most susceptible to the impact of change. Marine environments include regions that act as net sources or sinks for numerous climateactive trace gases including methane (CH4) and nitrous oxide (N2O). The temporal and spatial distributions of CH4 and N2O are controlled by the interaction of complex biogeochemical and physical processes. To evaluate and quantify how these mechanisms affect marine CH4 and N2O cycling requires a combination of traditional scientific disciplines including oceanography, microbiology, and …

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Association Between Appendicular Skeletal Muscle Index And Leukocyte Telomere Length In Adults: A Study From National Health And Nutrition Examination Survey (Nhanes) 1999-2002, Lingzhi Chen, Nitin Shivaooa, Xiuxun Dong, Jingjing Ming Nov 2020

Association Between Appendicular Skeletal Muscle Index And Leukocyte Telomere Length In Adults: A Study From National Health And Nutrition Examination Survey (Nhanes) 1999-2002, Lingzhi Chen, Nitin Shivaooa, Xiuxun Dong, Jingjing Ming

Faculty Publications

Background A higher body mass index (BMI) is associated with shorter telomeres. The loss of muscle mass with aging is associated with adverse outcomes. The appendicular skeletal muscle index (ASMI) is currently used to quantify muscle mass. Objective We investigated the association of the ASMI with leukocyte telomere length in adult Americans. Methods This cross-sectional study used the National Health and Nutrition Examination Survey (NHANES) 1999–2002 dataset. Body composition was measured by dual-energy X-ray absorptiometry. Low muscle mass was defined using sex-specific thresholds of the appendicular skeletal muscle mass index (ASMI). The telomere-to-single-copy gene ratio (T/S ratio) was converted to …

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A Decade Review Of Triphosgene And Its Applications In Organic Reactions, Moshood O. Ganiu, Binod Nepal, Joshua P. Van Houten, Rendy Kartika Nov 2020

A Decade Review Of Triphosgene And Its Applications In Organic Reactions, Moshood O. Ganiu, Binod Nepal, Joshua P. Van Houten, Rendy Kartika

Faculty Publications

© 2020 Elsevier Ltd This review article highlights selected advances in triphosgene-enabled organic synthetic reactions that were reported in the decade of 2010–2019. Triphosgene is a versatile reagent in organic synthesis. It serves as a convenient substitute for the toxic phosgene gas. Despite its first known preparation in the late 19th century, the upward surge in the development of organic reactions using triphosgene interestingly began only three decades ago. Despite the relatively short history, triphosgene has been proven to be very useful in facilitating the preparation of a vast scope of value-added compounds, such as organohalides, acid chlorides, isocyanates, carbonyl …

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Weighing The Evidence For The Abundant-Center Hypothesis, Tad Dallas, Luca Santini, Alan Hastings Nov 2020

Weighing The Evidence For The Abundant-Center Hypothesis, Tad Dallas, Luca Santini, Alan Hastings

Faculty Publications

The abundant-center hypothesis posits that species density should be highest in the center of the geographic range or climatic niche of a species, based on the idea that the center of either will be the area with the highest demographic performance (e.g., greater fecundity, survival, or carrying capacity). While intuitive, current support for the hypothesis is quite mixed. Here, we discuss the current state of the abundant-center hypothesis, highlighting the relatively low level of support for the relationship. We then discuss the potential reasons for this lack of empirical support, emphasiz-ing the inherent ecological complexity which may prevent the observation …

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Natalia Shustova Answers Questions About 15 Years Of Research On Covalent Organic Frameworks, Natalia B. Shustova Prof. Dr. Nov 2020

Natalia Shustova Answers Questions About 15 Years Of Research On Covalent Organic Frameworks, Natalia B. Shustova Prof. Dr.

Faculty Publications

No abstract provided.

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Interleukin-17a Facilitates Chikungunya Virus Infection By Inhibiting Ifn-Α2 Expression, Biswas Neupane, Dhiraj Acharya, Farzana Nazneen, Gabriel Gonzalez-Fernandez, Alex Sutton Flynt, Fengwei Bai Nov 2020

Interleukin-17a Facilitates Chikungunya Virus Infection By Inhibiting Ifn-Α2 Expression, Biswas Neupane, Dhiraj Acharya, Farzana Nazneen, Gabriel Gonzalez-Fernandez, Alex Sutton Flynt, Fengwei Bai

Faculty Publications

Interferons (IFNs) are the key components of innate immunity and are crucial for host defense against viral infections. Here, we report a novel role of interleukin-17A (IL-17A) in inhibiting IFN-α2 expression thus promoting chikungunya virus (CHIKV) infection. CHIKV infected IL-17A deficient (Il17a−/−) mice expressed a higher level of IFN-α2 and developed diminished viremia and milder footpad swelling in comparison to wild-type (WT) control mice, which was also recapitulated in IL-17A receptor-deficient (Il17ra−/−) mice. Interestingly, IL-17A selectively blocked IFN-α2 production during CHIKV, but not West Nile virus (WNV) or Zika virus (ZIKV), infections. Recombinant IL-17A …

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Ferric Uptake Regulator (Fur) Reversibly Binds A [2fe-2s] Cluster To Sense Intracellular Iron Homeostasis In Escherichia Coli, Chelsey R. Fontenot, Homyra Tasnim, Kathryn A. Valdes, Codrina V. Popescu, Huangen Ding Nov 2020

Ferric Uptake Regulator (Fur) Reversibly Binds A [2fe-2s] Cluster To Sense Intracellular Iron Homeostasis In Escherichia Coli, Chelsey R. Fontenot, Homyra Tasnim, Kathryn A. Valdes, Codrina V. Popescu, Huangen Ding

Faculty Publications

© 2020 Fontenot et al. The ferric uptake regulator (Fur) is a global transcription factor that regulates intracellular iron homeostasis in bacteria. The current hypothesis states that when the intracellular “free” iron concentration is elevated, Fur binds ferrous iron, and the iron-bound Fur represses the genes encoding for iron uptake systems and stimulates the genes encoding for iron storage proteins. However, the “iron-bound” Fur has never been isolated from any bacteria. Here we report that the Escherichia coli Fur has a bright red color when expressed in E. coli mutant cells containing an elevated intracellular free iron content because of …

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The Transition From Stochastic To Deterministic Bacterial Community Assembly During Permafrost Thaw Succession, Stacey J. Doherty, Robyn A. Barbato, A. Stuart Grandy, W. Kelley Thomas, Sylvain Monteux, Ellen Dorrepaal, Margareta Johansson, Jessica G. Ernakovich Nov 2020

The Transition From Stochastic To Deterministic Bacterial Community Assembly During Permafrost Thaw Succession, Stacey J. Doherty, Robyn A. Barbato, A. Stuart Grandy, W. Kelley Thomas, Sylvain Monteux, Ellen Dorrepaal, Margareta Johansson, Jessica G. Ernakovich

Faculty Publications

The Northern high latitudes are warming twice as fast as the global average, and permafrost has become vulnerable to thaw. Changes to the environment during thaw leads to shifts in microbial communities and their associated functions, such as greenhouse gas emissions. Understanding the ecological processes that structure the identity and abundance (i.e., assembly) of pre- and post-thaw communities may improve predictions of the functional outcomes of permafrost thaw. We characterized microbial community assembly during permafrost thaw using in situ observations and a laboratory incubation of soils from the Storflaket Mire in Abisko, Sweden, where permafrost thaw has occurred over the …

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