Digital Commons Network^™

Oral Absorption And Drug Interaction Kinetics Of Moxifloxacin In An Animal Model Of Weightlessness, Dong Liang, Jing Ma, Bo Wei

Faculty Publications

To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat model of microgravity. Fasted control and TS, jugular-vein-cannulated, male Sprague-Dawley rats received either a single 5 mg/kg intravenous dose or a single 10 mg/kg oral dose of moxifloxacin alone or with a 0.625 mL/kg oral dose of Maalox or a 1.43 mL/kg oral dose of Pepto-Bismol. Plasma concentrations of moxifloxacin were measured by HPLC. Pharmacokinetic data were analyzed using WinNonlin. Simulated weightlessness had no effect on moxifloxacin disposition after intravenous administration but significantly …

Spatiotemporal Variability Of Fishery‐Dependent Indices For The Declining Louisiana Southern Flounder Fishery, David R. Smith, Michael A. Dance, Joe West, Stephen R. Midway

Faculty Publications

No abstract provided.

Body Size, Trophic Position, And The Coupling Of Different Energy Pathways Across A Saltmarsh Landscape, Friedrich W. Keppeler, Jill A. Olin, Paola C. López‐Duarte, Michael J. Polito, Linda M. Hooper‐Bùi, Sabrina S. Taylor, Nancy N. Rabalais, F. Joel Fodrie, Brian J. Roberts, R. Eugene Turner, Charles W. Martin, Olaf P. Jensen

Faculty Publications

No abstract provided.

Terrapin Station: Individual, Sex, And Site Factors Related To Turtle Growth Variability, Leigh Anne Harden, Stephen R. Midway, J. Whitfield Gibbons

Faculty Publications

For many turtle species, life history traits such as body size, age at maturity, and somatic growth rate can vary among individuals and habitats and between the sexes. Therefore, it is important to consider factors that may influence growth when modeling (somatic) growth for turtles. Long-term capture-mark-recapture studies lend themselves to studying somatic growth in turtles due to the repeated measurements of individuals over time. We used a long-term dataset to examine growth patterns of philopatric Diamondback Terrapins (Malaclemys terrapin) on Kiawah Island, South Carolina, USA. We used a hierarchical three-parameter von Bertalanffy model to estimate individual growth of 44 …

Shark Side Of The Moon: Are Shark Attacks Related To Lunar Phase?, Lindsay A. French, Stephen R. Midway, David H. Evans, George H. Burgess

Faculty Publications

Animals across taxa have shown behaviors linked to moon phase (or the proxy of lunar illumination), and marine organisms are well-documented to calibrate certain activities with the moon. Few studies have looked at a possible connection between moon phase and shark attacks on humans, and the results have been preliminary or lacking relationships. We used nearly 50 years of shark attack data from across the globe to test for a relationship between shark attacks and moon phase. We examined factors of geography, shark species, and outcome of attack. From 12 relationships that we tested (totaling 120 comparisons), we found 12 …

Publisher Correction: Hydro-Climatic Changes Of Wetlandscapes Across The World (Scientific Reports, (2021), 11, 1, (2754), 10.1038/S41598-021-81137-3), I. Åhlén, G. Vigouroux, G. Destouni, J. Pietroń, N. Ghajarnia, J. Anaya, J. Blanco, S. Borja, S. Chalov, K. P. Chun, N. Clerici, A. Desormeaux, P. Girard, O. Gorelits, A. Hansen, F. Jaramillo, Z. Kalantari, A. Labbaci, L. Licero-Villanueva, J. Livsey, G. Maneas, K. L.Mc Curley Pisarello, D. Moshir Pahani, S. Palomino-Ángel, R. Price, C. Ricaurte-Villota, L. Fernanda Ricaurte, V. H. Rivera-Monroy, A. Rodriguez, E. Rodriguez, J. Salgado, B. Sannel, S. Seifollahi-Aghmiuni

Faculty Publications

In the original version of this Article, V. H. Rivera-Monroy was incorrectly affiliated with ‘Alexander von Humboldt Biological Resources Research Institute, Calle 28 A No. 15-09, Bogotá, DC, 70803, Colombia’. The correct affiliation is listed below. Department of Oceanography and Coastal Sciences, College of the Coast and Environment, Louisiana State University, Baton Rouge, LA 70803, USA As a result, Affiliations 22–27 were incorrectly listed as Affiliations 21–26 respectively. The original Article has been corrected.

Domoic Acid And Pseudo-Nitzschia Spp. Connected To Coastal Upwelling Along Coastal Inhambane Province, Mozambique: A New Area Of Concern, Holly Kelchner, Katie E. Reeve-Arnold, Kathryn M. Schreiner, Sibel Bargu, Kim G. Roques, Reagan M. Errera

Faculty Publications

Harmful algal blooms (HABs) are increasing globally in frequency, persistence, and geo-graphic extent, posing a threat to ecosystem and human health. To date, no occurrences of marine phycotoxins have been recorded in Mozambique, which may be due to absence of a monitoring program and general awareness of potential threats. This study is the first documentation of neurotoxin, domoic acid (DA), produced by the diatom Pseudo-nitzschia along the east coast of Africa. Coastal Inhambane Province is a biodiversity hotspot where year-round Rhincodon typus (whale shark) sightings are among the highest globally and support an emerging ecotourism industry. Links between primary productivity …

Isolating The White Matter Circuitry Of The Dorsal Language Stream: Connectome-Symptom Mapping In Stroke Induced Aphasia, Vatche Baboyan, Alexandra Basilaskos, Grigori Yourganov, Chris Rorden, Leonardo Bonilha, Julius Fridiksson, Gregory Hickok

Faculty Publications

The application of �� 1 -regularized machine learning models to high-dimensional connectomes offers a promising methodology to assess clinical-anatomical correlations in humans. Here, we integrate the connectome-based lesion-symptom mapping framework with sparse partial least squares regression (sPLS-R) to isolate elements of the connectome associated with speech repetition deficits. By mapping over 2,500 connections of the structural connectome in a cohort of 71 stroke-induced cases of aphasia presenting with varying left-hemisphere lesions and repetition impairment, sPLS-R was trained on 50 subjects to algorithmically identify connectomic features on the basis of their predictive value. The highest ranking features were subsequently used to …

International Society Of Sports Nutrition Position Stand: Caffeine And Exercise Performance, Nanci S. Guest, Trisha A. Vandusseldorp, Michael T. Nelson, Jozo Grgic, Brad J. Schoenfeld, Nathaniel D.M. Jenkins, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Jose Antonio, Jeffrey R. Stout, Eric T. Trexler, Abbie E. Smith-Ryan, Erica R. Goldstein, Douglas S. Kalman, Bill I. Campbell

Faculty Publications

Following critical evaluation of the available literature to date, The International Society of Sports Nutrition (ISSN) position regarding caffeine intake is as follows:1.Supplementation with caffeine has been shown to acutely enhance various aspects of exercise performance in many but not all studies. Small to moderate benefits of caffeine use include, but are not limited to: muscular endurance, movement velocity and muscular strength, sprinting, jumping, and throwing performance, as well as a wide range of aerobic and anaerobic sport-specific actions.2.Aerobic endurance appears to be the form of exercise with the most consistent moderate-to-large benefits from caffeine use, although the magnitude of …

Degradative Tubular Lysosomes Link Pexophagy To Starvation And Early Aging In C. Elegans, D A. Dolese, M P. Junot, B Ghosh, T J. Butsch, D A. Dolese, K A. Bohnert

Faculty Publications

Organelle-specific autophagy directs degradation of eukaryotic organelles under certain conditions. Like other organelles, peroxisomes are subject to autophagic turnover at lysosomes. However, peroxisome autophagy (pexophagy) has yet to be analyzed in a live-animal system, limiting knowledge on its regulation during an animal's life. Here, we generated a tandem-fluorophore reporter that enabled real-time tracking of pexophagy in live Caenorhabditis elegans. We observed that pexophagy occurred at a population of non-canonical, tubular lysosomes specifically during starvation and aging. Remarkably, in these contexts, tubular lysosomes were the predominant type of lysosome in the intestine, transforming from vesicles. Though we found that peroxisomes were …

The Dynamics Of Introgression Across An Avian Radiation, S Singhal, G E. Derryberry, G A. Bravo, E P. Derryberry, S Singhal, M G. Harvey

Faculty Publications

Hybridization and resulting introgression can play both a destructive and a creative role in the evolution of diversity. Thus, characterizing when and where introgression is most likely to occur can help us understand the causes of diversification dynamics. Here, we examine the prevalence of and variation in introgression using phylogenomic data from a large (1300+ species), geographically widespread avian group, the suboscine birds. We first examine patterns of gene tree discordance across the geographic distribution of the entire clade. We then evaluate the signal of introgression in a subset of 206 species triads using Patterson's D-statistic and test for associations …

Solid-State Nmr Of Unlabeled Plant Cell Walls: High-Resolution Structural Analysis Without Isotopic Enrichment, Wancheng Zhao, Alex Kirui, Fabien Deligey, Frederic Mentink-Vigier, Yihua Zhou, Baocai Zhang, Tuo Wang

Faculty Publications

© 2021, The Author(s). Background: Multidimensional solid-state nuclear magnetic resonance (ssNMR) spectroscopy has emerged as an indispensable technique for resolving polymer structure and intermolecular packing in primary and secondary plant cell walls. Isotope (13C) enrichment provides feasible sensitivity for measuring 2D/3D correlation spectra, but this time-consuming procedure and its associated expenses have restricted the application of ssNMR in lignocellulose analysis. Results: Here, we present a method that relies on the sensitivity-enhancing technique Dynamic Nuclear Polarization (DNP) to eliminate the need for 13C-labeling. With a 26-fold sensitivity enhancement, a series of 2D 13C–13C correlation spectra were successfully collected using the unlabeled …

Adult Cold Tolerance And Potential North American Distribution Of Myllocerus Undecimpustulatus Undatus (Coleoptera: Curculionidae), Anita S. Neal, Rodrigo Diaz, Jawwad A. Qureshi, Ronald D. Cave

Faculty Publications

Cold tolerance and potential distribution of Myllocerus undecimpustulatus undatus Marshall, a polyphagous pest in the United States, were investigated. Adult survivorship after 2 days at 0 °C and − 5 °C averaged 60% and 18%, respectively. Four days of exposure resulted in survivorship of 11% at 0 °C and 4% at − 5 °C, respectively. Summer-collected weevils at − 5 °C through repeated cold exposure of 2 h survived 3 times longer than those subjected to sustained cold period of 10 h. Leaf consumption did not differ among summer-collected weevils at constant 20 °C and repeated cold exposure treatments; weevils …

Immune-Related Genes Of The Larval Holotrichia Parallela In Response To Entomopathogenic Nematodes Heterorhabditis Beicherriana Lf, Ertao Li, Jianhui Qin, Honglin Feng, Jinqiao Li, Xiaofeng Li, Innocent Nyamwasa, Yazhong Cao, Weibin Ruan, Kebin Li, Jiao Yin

Faculty Publications

Background: Entomopathogenic nematodes (EPNs) emerge as compatible alternatives to conventional insecticides in controlling Holotrichia parallela larvae (Coleoptera: Scarabaeidae). However, the immune responses of H. parallela against EPNs infection remain unclear. Results: In present research, RNA-Seq was firstly performed. A total of 89,427 and 85,741 unigenes were achieved from the midgut of H. parallela larvae treated with Heterorhabditis beicherriana LF for 24 and 72 h, respectively; 2545 and 3156 unigenes were differentially regulated, respectively. Among those differentially expressed genes (DEGs), 74 were identified potentially related to the immune response. Notably, some immune-related genes, such as peptidoglycan recognition protein SC1 (PGRP-SC1), pro-phenoloxidase …

Management Of Stemborers (Lepidoptera: Crambidae) Using Foliar-Applied Chlorantraniliprole In Rice, James M. Villegas, Blake E. Wilson, Michael O. Way

Faculty Publications

Rice is one of the most important crops in Louisiana and Texas, USA. It is subjected to various insect pests throughout the growing season. Lepidopteran stem-boring pests including the Mexican rice borer, Eoreuma loftini (Dyar) (Lepidoptera: Crambidae), are increasing in economic importance as insect pests in rice production, particularly in southwest Louisiana, USA. Field trials were conducted in Louisiana and Texas to examine the efficacy of foliar-applied insecticides (chlorantraniliprole and the pyrethroids ζ-cypermethrin and λ-cyhalothrin) and chlorantraniliprole seed treatment for control of rice stemborers during 2018 and 2019. Furthermore, a diet incorporation assay assessed the toxicity of chlorantraniliprole to laboratory-reared …

Bridgehead Effect And Multiple Introductions Shape The Global Invasion History Of A Termite, Alexander J. Blumenfeld, Pierre André Eyer, Claudia Husseneder, Jianchu Mo, Laura N.L. Johnson, Changlu Wang, J. Kenneth Grace, Thomas Chouvenc, Shichen Wang, Edward L. Vargo

Faculty Publications

Native to eastern Asia, the Formosan subterranean termite Coptotermes formosanus (Shiraki) is recognized as one of the 100 worst invasive pests in the world, with established populations in Japan, Hawaii and the southeastern United States. Despite its importance, the native source(s) of C. formosanus introductions and their invasive pathway out of Asia remain elusive. Using ~22,000 SNPs, we retraced the invasion history of this species through approximate Bayesian computation and assessed the consequences of the invasion on its genetic patterns and demography. We show a complex invasion history, where an initial introduction to Hawaii resulted from two distinct introduction events …

Cardiovascular Disease And Risk Of Incident Diabetes Mellitus: Findings From The Hispanic Community Health Study/Study Of Latinos (Hchs/Sol), Celestin Missikpode, Ramon A. Durazo-Arvizu, Richard S. Cooper, Matthew James OʼBrien, Sheila F. Castaneda, Gregory A. Talavera, Linda C. Gallo, Maria M. Llabre, Marisa J. Perera, Krista M. Perreira, Ana C. Ricardo, Amber Pirzada, James P. Lash, Martha Daviglus

Faculty Publications

Background: Studies have reported an association between prevalent cardiovascular disease (CVD) and risk of diabetes mellitus (DM). However, factors that may explain the association remain unclear. We examined the association of prevalent CVD with incident DM and assessed whether weight gain and medication use may explain the association. Methods: Data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Visit 1 (2008-2011) and Visit 2 (2014-2017) were used to compare incidence of DM among individuals with and without self-reported CVD at Visit 1. A total of 1899 individuals with self-reported CVD were matched to controls free of self-reported CVD at …

Association Of Body Composition With Odds Of Breast Cancer By Molecular Subtype: Analysis Of The Mechanisms For Established And Novel Risk Factors For Breast Cancer In Nigerian Women (Mend) Study, Tomi Akinyemiju, Kelley Jones, Anjali Gupta, Taofik Oyekunle, Veeral Saraiya, April Deveaux, Omolola Salako, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna Arnett, Samuel Ajayi, Yemi Raji, Timothy Olanrewaju, Charlotte Osafo, Ifeoma Ulasi, Adanze Asinobi, Cheryl A. Winkler, David Burke, Fatiu Arogundade, Ivy Ekem, Jacob Plange-Rhule, Manmak Mamven

Faculty Publications

Background: The association between obesity and breast cancer (BC) has been extensively studied among US, European and Asian study populations, with often conflicting evidence. However, despite the increasing prevalence of obesity and associated conditions in Africa, the continent with the highest age-standardized BC mortality rate globally, few studies have evaluated this association, and none has examined in relation to molecular subtypes among African women. The current analysis examines the association between body composition, defined by body mass index (BMI), height, and weight, and BC by molecular subtype among African women. Methods: We estimated odds ratios (ORs) and 95% confidence intervals …

Whole Genome Comparisons Reveal Panmixia Among Fall Armyworm (Spodoptera Frugiperda) From Diverse Locations, Katrina A. Schlum, Kurt Lamour, Caroline Placidi De Bortoli, Rahul Banerjee, Robert Meagher, Eliseu Pereira, Maria Gabriela Murua, Gregory A. Sword, Ashley E. Tessnow, Diego Viteri Dillon, Angela M. Linares Ramirez, Komivi S. Akutse, Rebecca Schmidt-Jeffris, Fangneng Huang, Dominic Reisig, Scott J. Emrich, Juan Luis Jurat-Fuentes

Faculty Publications

Background: The fall armyworm (Spodoptera frugiperda (J.E. Smith)) is a highly polyphagous agricultural pest with long-distance migratory behavior threatening food security worldwide. This pest has a host range of > 80 plant species, but two host strains are recognized based on their association with corn (C-strain) or rice and smaller grasses (R-strain). The population genomics of the United States (USA) fall armyworm remains poorly characterized to date despite its agricultural threat. Results: In this study, the population structure and genetic diversity in 55 S. frugiperda samples from Argentina, Brazil, Kenya, Puerto Rico and USA were surveyed to further our understanding of …

Environmental Rnai Pathways In The Two-Spotted Spider Mite, Mosharrof Mondal, Jacob Peter, Obrie Scarbrough, Alex Flynt

Faculty Publications

© 2020, The Author(s).

Background:RNA interference (RNAi) regulates gene expression in most multicellular organisms through binding of small RNA effectors to target transcripts. Exploiting this process is a popular strategy for genetic manipulation and has applications that includes arthropod pest control. RNAi technologies are dependent on delivery method with the most convenient likely being feeding, which is effective in some animals while others are insensitive. The two-spotted spider mite, Tetranychus urticae, is prime candidate for developing RNAi approaches due to frequent occurrence of conventional pesticide resistance. Using a sequencing-based approach, the fate of ingested RNAs was explored to …

Ale Beer Containing Free And Immobilized Lactobacillus Brevis, A Potential Delivery System For Probiotics, Kriza Faye Calumba, Vondel Reyes, Franklin Bonilla, Elio Villasmil, Subramaniam Sathivel

Faculty Publications

Abstract: Probiotics in ale beer may be attractive to health-conscious consumers. However, beer conditions may decrease probiotic viability. Powder produced from durian (Durio zibethinus) rind, a by-product that is currently unutilized, can be used for the immobilization of probiotics. MRS medium was incubated with Lactobacillus brevis and periodically sampled to obtain the growth curve. Ale beer with free L. brevis and cells immobilized in durian rind powder was produced and separately assessed during storage at 21 °C for 24 days. The physico-chemical parameters of both beers did not differ significantly. Durian rind powder conferred protection up to 12 days of …

Fourteen New, Endemic Species Of Shrew (Genus Crocidura) From Sulawesi Reveal A Spectacular Island Radiation, Jacob A. Esselstyn, Anang S. Achmadi, Heru Handika, Mark T. Swanson, Thomas C. Giarla, Kevin C. Rowe

Faculty Publications

After nearly a decade of field inventories in which we preserved voucher specimens of the small terrestrial mammals of Sulawesi, we combined qualitative and quantitative analyses of morphological traits with molecular phylogenetics to better understand the diversity of shrews (Soricidae: Crocidura) on the island. We examined the morphology of 1368 specimens and obtained extensive molecular data from many of them, including mitochondrial DNA sequences from 851 specimens, up to five nuclear exons from 657 specimens, and thousands of ultraconserved elements from 90 specimens. By iteratively testing species limits using distinct character datasets and appropriate taxon sampling, we found clear, mostly …

Spectroscopic Studies Of The Interaction Between Phosphorus Heterocycles And Cytochrome P450, Dumei Ma, Libo Zhang, Yingwu Yin, Yuxing Gao, Qian Wang

Faculty Publications

P450 fatty acid decarboxylase OleT from Staphylococcus aureus (OleT_SA) is a novel cytochrome P450 enzyme that catalyzes the oxidative decarboxylation of fatty acids to yield primarily terminal alkenes and CO₂ or minor α- and β-hydroxylated fatty acids as side-products. In this work, the interactions between a series of cycloalkyl phosphorus heterocycles (CPHs) and OleT_SA were investigated in detail by fluorescence titration experiment, ultraviolet–visible (UV–vis) and ³¹P NMR spectroscopies. Fluorescence titration experiment results clearly showed that a dynamic quenching occurred when CPH-6, a representative CPHs, interacted with OleT_SA with a binding constant value of 15.2 …

Survivals Of Two Cooperating Species Of Animals, Joon Hyuk Kang

Faculty Publications

The purpose of this paper is to give conditions for the existence and uniqueness of positive solution to a rather general type of elliptic system of the Dirichlet problem on a bounded domain Ω" role="presentation" style="box-sizing: border-box; margin: 0px; padding: 0px; display: inline-block; line-height: normal; font-size: 16.2px; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; position: relative;">Ω in Rn" role="presentation" style="box-sizing: border-box; margin: 0px; padding: 0px; display: inline-block; line-height: normal; font-size: 16.2px; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: …

Ultra-Conformal Skin Electrodes With Synergistically Enhanced Conductivity For Long-Time And Low-Motion Artifact Epidermal Electrophysiology, Yan Zhao, Song Zhang, Tianhao Yu, Yan Zhang, Guo Ye, Han Cui, Chengzhi He, Wenchao Jiang, Yu Zhai, Chunming Lu, Xiaodan Gu, Nan Liu

Faculty Publications

Accurate and imperceptible monitoring of electrophysiological signals is of primary importance for wearable healthcare. Stiff and bulky pregelled electrodes are now commonly used in clinical diagnosis, causing severe discomfort to users for long-time using as well as artifact signals in motion. Here, we report a ~100 nm ultra-thin dry epidermal electrode that is able to conformably adhere to skin and accurately measure electrophysiological signals. It showed low sheet resistance (~24 Ω/sq, 4142 S/cm), high transparency, and mechano-electrical stability. The enhanced optoelectronic performance was due to the synergistic effect between graphene and poly (3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), which induced a high …

Metacognition, Social Cognition, And Mentalizing In Psychosis: Are These Distinct Constructs When It Comes To Subjective Experience Or Are We Just Splitting Hairs?, P. H. Lysaker, S. Cheli, G. Dimaggio, B. Buck, K. A. Bonfils, K. Huling, C. Wiesepape, J. T. Lysaker

Faculty Publications

Research using the integrated model of metacognition has suggested that the construct of metacognition could quantify the spectrum of activities that, if impaired, might cause many of the subjective disturbances found in psychosis. Research on social cognition and mentalizing in psychosis, however, has also pointed to underlying deficits in how persons make sense of their experience of themselves and others. To explore the question of whether metacognitive research in psychosis offers unique insight in the midst of these other two emerging fields, we have offered a review of the constructs and research from each field. Following that summary, we discuss …

Label-Free Characterization Of Organic Nanocarriers Reveals Persistent Single Molecule Cores For Hydrocarbon Sequestration, Terry Mcafee, Thomas Ferron, Isvar A. Cordova, Phillip D. Pickett, Charles L. Mccormick, Cheng Wang, Brian A. Collins

Faculty Publications

Self-assembled molecular nanostructures embody an enormous potential for new technologies, therapeutics, and understanding of molecular biofunctions. Their structure and function are dependent on local environments, necessitating in-situ/operando investigations for the biggest leaps in discovery and design. However, the most advanced of such investigations involve laborious labeling methods that can disrupt behavior or are not fast enough to capture stimuli-responsive phenomena. We utilize X-rays resonant with molecular bonds to demonstrate an in-situ nanoprobe that eliminates the need for labels and enables data collection times within seconds. Our analytical spectral model quantifies the structure, molecular composition, and dynamics of a copolymer micelle …

Nutrient Content And Stoichiometry Of Pelagic Sargassum Reflects Increasing Nitrogen Availability In The Atlantic Basin, B. E. Lapointe, R. A. Brewton, L. W. Herren, M. Wang, C. Hu, D. J. Mcgillicuddy, S. Lindell, F. J. Hernandez, P. L. Morton

Faculty Publications

The pelagic brown macroalgae Sargassum spp. have grown for centuries in oligotrophic waters of the North Atlantic Ocean supported by natural nutrient sources, such as excretions from associated fishes and invertebrates, upwelling, and N₂ fixation. Using a unique historical baseline, we show that since the 1980s the tissue %N of Sargassum spp. has increased by 35%, while %P has decreased by 44%, resulting in a 111% increase in the N:P ratio (13:1 to 28:1) and increased P limitation. The highest %N and δ¹⁵N values occurred in coastal waters influenced by N-rich terrestrial runoff, while lower C:N and …

Accurate Diagnosis Of Colorectal Cancer Based On Histopathology Images Using Artificial Intelligence, K. S. Wang, G. Yu, C. Xu, X. H. Meng, J. Zhou, C. Zheng, Z. Deng, L. Shang, R. Liu, S. Su, X. Zhou, Q. Li, J. Li, J. Wang, K. Ma, J. Qi, Z. Hu, P. Tang, J. Deng, X. Qiu, B. Y. Li, W. D. Shen, R. P. Quan, J. T. Yang, L. Y. Huang, Y. Xiao, Z. C. Yang, Z. Li, S. C. Wang, H. Ren, C. Liang, W. Guo, Y. Li, H. Xiao, Y. Gu, J.P. Yun, D. Huang, Z. Song, X. Fan, L. Chen, X. Yan, Z. Li, Z.C. Huang, J. Huang, J. Luttrell, Chaoyang Zhang, W. Zhou, K. Zhang, C. Yi, C. Wu, H. Shen, Y.P. Wang, H.M. Xiao, H.W. Deng

Faculty Publications

Background: Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patients’ treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis of CRC based on daily image analyses.

Methods: Based on a state-of-the-art transfer-learned deep convolutional neural network in artificial intelligence (AI), we proposed a novel patch aggregation strategy for clinic CRC diagnosis using weakly labeled pathological whole-slide image (WSI) patches. This approach was trained and validated using an unprecedented and enormously large number of 170,099 patches, > 14,680 WSIs, from > 9631 subjects …

Monitoring Fine-Scale Forest Health Using Unmanned Aerial Systems (Uas) Multispectral Models, Benjamin T. Fraser, Russell G. Congalton

Faculty Publications

Forest disturbances—driven by pests, pathogens, and discrete events—have led to billions of dollars in lost ecosystem services and management costs. To understand the patterns and severity of these stressors across complex landscapes, there must be an increase in reliable data at scales compatible with management actions. Unmanned aerial systems (UAS or UAV) offer a capable platform for collecting local scale (e.g., individual tree) forestry data. In this study, we evaluate the capability of UAS multispectral imagery and freely available National Agricultural Imagery Program (NAIP) imagery for differentiating coniferous healthy, coniferous stressed, deciduous healthy, deciduous stressed, and degraded individual trees throughout …