Digital Commons Network^™

Improvements In Blood Pressure Among Undiagnosed Hypertensive Participants In A Community-Based Lifestyle Intervention, Mississippi, 2010, Jamie M. Zoellner, Jessica L. Thomson, Alicia S. Landry, Charkarra Anderson-Lewis, Carol Connell, Elaine Fontenot Molaison, Kathleen Yadrick

Faculty Publications

Introduction

Effective strategies are needed to reach and treat people who lack awareness of or have uncontrolled hypertension. We used data from a community-based participatory research initiative, Hub City Steps, to quantify the prevalence of undiagnosed hypertension and determine the relationship between hypertension status at baseline and postintervention improvements in blood pressure and health-related quality of life.

Methods

Hub City Steps was a 6-month preintervention–postintervention lifestyle intervention targeting hypertension risk factors. Outcome measures were collected at baseline, 3 months, and 6 months. Generalized linear mixed models were used to test for effects by time and hypertension status.

Results

Of the …

Understanding How Service-Learning Impacts The Dispositions Of Teach For America Candidates And Their Students, Dymaneke Mitchell, Sy Karlin, Todd Alan Price

Faculty Publications

This article is based on a study that assessed Teach for America (TFA) candidates’ dispositions toward service-learning before and after they developed and implemented a service-learning project with their students. This article may be used to understand the significance of raising alternative certification teacher candidates’ community awareness so that they may stay longer as teachers while also becoming more acculturated to their school and neighborhood surroundings. The authors assert that candidates will become more effective through carefully planned service-learning experiences with community partners and become better service and public education advocates.

Unpermitted Urban Agriculture: Transgressive Actions, Changing Norms And The Local Food Movement, Sarah B. Schindler

Faculty Publications

Roberta keeps four chickens in her backyard. Bob snuck onto the vacant lot next door, which the bank foreclosed upon and now owns, and planted a vegetable garden. Vien operates an occasional underground restaurant from his friends’ microbrewery after beer-making operations cease for the day. The common thread tying these actions together is that they are unauthorized; they are being undertaken in violation of existing laws and often norms. In this Article, I explore ideas surrounding the overlap between food policy and land use law, specifically the transgressive1 actions that people living in urban and suburban communities are undertaking to …

Hub City Steps: A 6-Month Lifestyle Intervention Improves Blood Pressure Among A Primarily African-American Community, Jamie M. Zoellner, Carol Connell, Michael B. Modson, Jessica L. Thomson, Alicia S. Landry, Elaine Fontenot Molaison, Vickie Blakely Reed, Kathleen Yadrick

Faculty Publications

The effectiveness of community-based participatory research (CBPR) efforts to address the disproportionate burden of hypertension among African Americans remains largely untested. The objective of this 6-month, noncontrolled, pre-/post-experimental intervention was to examine the effectiveness of a CBPR intervention in achieving improvements in blood pressure, anthropometric measures, biological measures, and diet. Conducted in 2010, this multicomponent lifestyle intervention included motivational enhancement, social support provided by peer coaches, pedometer diary self-monitoring, and monthly nutrition and physical activity education sessions. Of 269 enrolled participants, 94% were African American and 85% were female. Statistical analysis included generalized linear mixed models using maximum likelihood estimation. …

Health Insurance Status, Psychological Processes, And Older African Americans' Use Of Preventive Care, Catherine Walker O'Neal, Kandauda A.S. Wickrama, Penny A. Ralston, Jasminka Z. Elich, Cynthia M. Harris, Catherine Coccia, Iris Young-Clark, Jennifer Lemacks

Faculty Publications

The current study examined the influence of health insurance, psychological processes (i.e. psychological competency and vulnerability), and the interaction of these two constructs on older African Americans' utilization of five preventive care services (e.g. cholesterol screening and mammogram/prostate examination) using data from 211 older African Americans (median age = 60). In addition to direct effects, the influence of health insurance sometimes varied depending on respondents' psychological competency and/or vulnerability. Policies and interventions to increase older African Americans' use of preventive health services should consider structural (e.g. health insurance) and psychological (e.g. psychological competency and vulnerability) factors along with the interaction …

Mechanisms Of Soil Carbon Accrual And Storage In Bioenergy Cropping Systems, Lisa K. Tiemann, A. Stuart Grandy

Faculty Publications

Annual row cropping systems converted to perennial bioenergy crops tend to accrue soil C, likely a function of increased root production and decreased frequency of tillage; however, very little is known about the mechanisms governing the accrual and stability of this additional soil C. To address this uncertainty, we assessed the formation and stability of aggregates and soil organic C (SOC) pools under switchgrass, giant miscanthus, a native perennial grass mix and continuous corn treatments in Michigan and Wisconsin soils differing in both texture and mineralogy. We isolated different aggregate size fractions, >2 mm, 0.5–2 mm, and <0.5 mm, using a procedure intended to minimize alterations to aggregate biological and chemical properties. We determined SOC, permanganate oxidizable C (POXC), and microbial activities (i.e. enzyme activities and soil respiration rates) associated with these aggregates. Soil type strongly influenced the trajectory of aggregate formation and stabilization with differences between sites in mean aggregate size, stability, SOC and microbial activity under perennial vs. corn cropping systems. At the Michigan site, soil microbial activities were highest in the >2 mm aggregates, …

Resistant Starch From High Amylose Maize (Ham-Rs2) And Dietary Butyrate Reduce Abdominal Fat By A Different Apparent Mechanism, Kirk Vidrine, Jianping Ye, Roy J. Martin, Kathleen L. Mccutcheon, Anne M. Raggio, Christine Pelkman, Holiday A. Durham, June Zhou, Reshani N. Senevirathne, Cathy Williams, Frank Greenway, John Finley, Zhanguo Gao, Felicia Goldsmith, Michael J. Keenan

Faculty Publications

Objective Obesity is a health concern. Resistant starch (RS) type 2 from high-amylose maize (HAM-RS2) and dietary sodium butyrate (SB) reduce abdominal fat in rodents. RS treatment is associated with increased gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), but it is not known if SB increases these hormones. Design and Methods This was investigated in a 2 × 2 rat study with HAM-RS2 (0 or 28% weight) and dietary sodium butyrate (0 and 3.2%) resulting in isocaloric treatments: energy control (EC), sodium butyrate (SB), HAM-RS2 (RS), and the combination (SBRS). Results RS and SB reduced abdominal fat …

Resistant Starch From High Amylose Maize (Ham-Rs2) And Dietary Butyrate Reduce Abdominal Fat By A Different Apparent Mechanism, Kirk Vidrine, Jianping Ye, Roy J. Martin, Kathleen L. Mccutcheon, Anne M. Raggio, Christine Pelkman, Holiday A. Durham, June Zhou, Reshani N. Senevirathne, Cathy Williams, Frank Greenway, John Finley, Zhanguo Gao, Felicia Goldsmith, Michael J. Keenan

Faculty Publications

Objective Obesity is a health concern. Resistant starch (RS) type 2 from high-amylose maize (HAM-RS2) and dietary sodium butyrate (SB) reduce abdominal fat in rodents. RS treatment is associated with increased gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), but it is not known if SB increases these hormones. Design and Methods This was investigated in a 2 × 2 rat study with HAM-RS2 (0 or 28% weight) and dietary sodium butyrate (0 and 3.2%) resulting in isocaloric treatments: energy control (EC), sodium butyrate (SB), HAM-RS2 (RS), and the combination (SBRS). Results RS and SB reduced abdominal fat …

Oncostatin M Is Produced In Adipose Tissue And Is Regulated In Conditions Of Obesity And Type 2 Diabetes, David Sanchez-Infantes, Ursula A. White, Carrie M. Elks, Ron F. Morrison, Jeffrey M. Gimble, Robert V. Considine, Anthony W. Ferrante, Eric Ravussin, Jacqueline M. Stephens

Faculty Publications

Context: Adipose tissue is a highly active endocrine organ that secretes many factors that affect other tissues and whole-body metabolism. Adipocytes are responsive to several glycoprotein 130 (gp130) cytokines, some of which have been targeted as potential antiobesity therapeutics. Objective: Oncostatin M (OSM) is a gp130 family member known to inhibit adipocyte differentiation in vitro, but its effects on other adipocyte properties are not characterized. The expression of OSM in white adipose tissue (WAT) has not been evaluated in the context of obesity. Thus, our objective was to examine the expression of adipose tissue OSM in obese animals and humans. …

Fetal Baboon Sex-Specific Outcomes In Adipocyte Differentiation At 0.9 Gestation In Response To Moderate Maternal Nutrient Reduction, Y. D. Tchoukalova, R. Krishnapuram, U. A. White, D. Burk, X. Fang, M. J. Nijland, P. W. Nathanielsz

Faculty Publications

Objective:To investigate in vitro adipocyte differentiation in baboon fetuses in response to reduced maternal nutrition.Design:Cross-sectional comparison of adipocyte differentiation in normally grown fetuses and fetuses of pregnant baboons fed 70% of the control global diet from 30 days of pregnancy to term.Subjects:The subjects comprised control (CTR) fetuses (five female and five male) of mothers fed ad libitum and fetuses of mothers fed 70% of the global diet consumed by CTR (maternal nutrient reduction (MNR), five female and five male fetuses). The expression of genes/proteins involved in adipogenesis (PPARγ, FABP4 and adiponectin) and brown adipose tissue development (UCP1, TBX15 and COXIV) …

Contributions Of Adipose Tissue Architectural And Tensile Properties Toward Defining Healthy And Unhealthy Obesity, Denise E. Lackey, David H. Burk, Mohamed R. Ali, Rouzbeh Mostaedi, William H. Smith, Jiyoung Park, Philipp E. Scherer, Shundra A. Seay, Colin S. Mccoin, Paolo Bonaldo, Sean H. Adams

Faculty Publications

The extracellular matrix (ECM) plays an important role in the maintenance of white adipose tissue (WAT) architecture and function, and proper ECM remodeling is critical to support WAT malleability to accomodate changes in energy storage needs. Obesity and adipocyte hypertrophy place a strain on the ECM remodeling machinery, which may promote disordered ECM and altered tissue integrity and could promote proinflammatory and cell stress signals. To explore these questions, new methods were developed to quantify omental and subcutaneous WAT tensile strength and WAT collagen content by three-dimensional confocal imaging, using collagen VI knockout mice as a methods validation tool. These …

Helping Young People Resist At-Risk Behaviors, Gary L. Hopkins, Duane C. Mcbride, Jacqueline Moreno, Susan Armstrong, Joni Roberts, Donavan Andregg

Faculty Publications

This article will deal with some at-risk behaviors that are new to our times. Its goal is to provide a helpful kit filled with research-based strategies that teachers, parents, church and community leaders, counselors, health-care professionals, and others can use in their work with youth. In addition, the article will provide information that can be shared with young people who need to be aware of lurking dangers, as well as what strategies they can use both now and in the future, when they establish their own families. Because of the urgency of those matters, teachers and administrators should talk about …

Genomics Of Plant Abiotic Stress Tolerance, Dong Ha Oh, Maheshi Dassanayake, Hyewon Hong, Suja George, Seol Ki Paeng, Anna Kropornika, Ray A. Bressan, Sang Yeol Lee, Dae Jin Yun, Hans J. Bohnert

Faculty Publications

© 2014 by John Wiley & Sons, Inc. Genome sequences and RNA-seq data provide unparalleled views into the genetic basis that underlies plant phenotypes. This chapter outlines a paradigm shift in plant biology originating from the relative ease of generating sequences, and points to tools that have enabled global transcript analyses (RNA-seq), replacing arduous microarray hybridization experiments and laborious quantitative RT-PCR platform designs. Soon, it can be envisioned that one may replace individual transcript assays by measuring how the entire transcriptome responds globally to a manipulation or mutation. The chapter advances a position that the knowledge of genome content and …

Erratum: Peg3 Mutational Effects On Reproduction And Placenta-Specific Gene Families (Plos One (2014) 9:1 Doi: 10.1371/Annotation/8de03ec5-E62c-4135-87ee- 4928475090a8), Joomyeong Kim, Wesley D. Frey, Hongzhi He, Hana Kim, Muhammad B. Ekram, Arundhati Bakshi, Mohammad Faisal, Bambarendage P.U. Perera, An Ye, Ryoichi Teruyama

Faculty Publications

No abstract provided.

Aphid Amino Acid Transporter Regulates Glutamine Supply To Intracellular Bacterial Symbionts, Daniel R.G. Price, Honglin Feng, James D. Baker, Selvan Bavan, Charles W. Luetje, Alex C.C. Wilson

Faculty Publications

Endosymbiotic associations have played a major role in evolution. However, the molecular basis for the biochemical interdependence of these associations remains poorly understood. The aphid-Buchnera endosymbiosis provides a powerful system to elucidate how these symbioses are regulated. In aphids, the supply of essential amino acids depends on an ancient nutritional symbiotic association with the gamma-proteobacterium Buchnera aphidicola. Buchnera cells are densely packed in specialized aphid bacteriocyte cells. Here we confirm that five putative amino acid transporters are highly expressed and/or highly enriched in Acyrthosiphon pisum bacteriocyte tissues. When expressed in Xenopus laevis oocytes, two bacteriocyte amino acid transporters displayed significant …

Feasibility And Acceptability Of An Early Childhood Obesity Prevention Intervention: Results From The Healthy Homes, Healthy Families Pilot Study, Akilah Dulin Keita, Patricia M. Risica, Kelli L. Drenner, Ingrid Adams, Gemma Gorham, Kim M. Gans

Faculty Publications

Background. This study examined the feasibility and acceptability of a home-based early childhood obesity prevention intervention designed to empower low-income racially/ethnically diverse parents to modify their children’s health behaviors. Methods. We used a prospective design with pre-/posttest evaluation of 50 parent-child pairs (children aged 2 to 5 years) to examine potential changes in dietary, physical activity, and sedentary behaviors among children at baseline and four-month follow-up. Results. 39 (78%) parent-child pairs completed evaluation data at 4-month follow-up. Vegetable intake among children significantly increased at follow-up (0.54 cups at 4 months compared to 0.28 cups at baseline, 𝑃 …

Text 4 Health: Addressing Consumer Health Information Needs Via Text Reference Service, Van M. Ta Park

Faculty Publications

This study seeks to provide empirical evidence about how health-related questions are answered in text reference service in order to further the understanding of how to best use texting as a reference service venue to fulfill people’s health information needs. Two hundred health reference transactions from My Info Quest, the first nation-wide collaborative text reference service, were analyzed identify the types of questions, length of transactions, question-answering behavior, and information sources used in the transactions. Findings indicate that texting-based health reference transactions are usually brief, and cover a wide variety of topics. The most popular questions are those seeking general …

Sarajevo Heart Of Europe? Global Politics, Symbol(Ism) & Liminality In The Centenary Of Ww1, Joan Davison

Faculty Publications

The analysis highlights the inter-connection and intra-connection between societal facts (mythology, symbols, and religion), socio-anthropological concepts (imitation, liminality), and psychological factors (human will and “I will”) with global politics. The approach identifies dynamics and “repetitions” which can affect individuals and societies, perpetuate tension and violence, and constrain certain political outcomes. Thus follows the particular shortcoming of International Relations theory as the product of rational choice, which strives to separate the unconscious from the conscious, to understand and remedy certain socio-political conflicts. Conversely, this analysis employs the theory on mimesis, imitation, hence, memory “me willed” (as the distillate of modernity). The …

The Anthropology Of Plague: Insights From Bioarcheological Analyses Of Epidemic Cemeteries, Sharon Dewitte

Faculty Publications

Most research on historic plague has relied on documentary evidence, but recently researchers have examined the remains of plague victims to produce a deeper understanding of the disease. Bioarcheological analysis allows the skeletal remains of epidemic victims to bear witness to the contexts of their deaths. This is important for our understanding of the experiences of the vast majority of people who lived in the past, who are not typically included in the historical record. This paper summarizes bioarcheological research on plague, primarily investigations of the Black Death in London (1349–50), emphasizing what anthropology uniquely contributes to plague studies.

Role Of Adipose Tissue In The Pathogenesis And Treatment Of Metabolic Syndrome, David Sanchez-Infantes, Jacqueline M. Stephens

Faculty Publications

© Springer International Publishing Switzerland 2014. Adipocytes are highly specialized cells that play a major role in energy homeostasis in vertebrate organisms. Excess adipocyte size or number is a hallmark of obesity, which is currently a global epidemic. Obesity is not only the primary disease of fat cells, but also a major risk factor for the development of Type 2 diabetes, cardiovascular disease, hypertension, and metabolic syndrome (MetS). Today, adipocytes and adipose tissue are no longer considered passive participants in metabolic pathways. In addition to storing lipid, adipocytes are highly insulin sensitive cells that have important endocrine functions. Altering any …

Response Of Native Insect Communities To Invasive Plants, T. Martijn Bezemer, Jeffrey A. Harvey, James T. Cronin

Faculty Publications

Invasive plants can disrupt a range of trophic interactions in native communities. As a novel resource they can affect the performance of native insect herbivores and their natural enemies such as parasitoids and predators, and this can lead to host shifts of these herbivores and natural enemies. Through the release of volatile compounds, and by changing the chemical complexity of the habitat, invasive plants can also affect the behavior of native insects such as herbivores, parasitoids, and pollinators. Studies that compare insects on related native and invasive plants in invaded habitats show that the abundance of insect herbivores is often …

Sexual Differences Of Imprinted Genes' Expression Levels, Mohammad Faisal, Hana Kim, Joomyeong Kim

Faculty Publications

In mammals, genomic imprinting has evolved as a dosage-controlling mechanism for a subset of genes that play critical roles in their unusual reproduction scheme involving viviparity and placentation. As such, many imprinted genes are highly expressed in sex-specific reproductive organs. In the current study, we sought to test whether imprinted genes are differentially expressed between the two sexes. According to the results, the expression levels of the following genes differ between the two sexes of mice: Peg3, Zim1, Igf2, H19 and Zac1. The expression levels of these imprinted genes are usually greater in males than in females. This bias is …

Ruminant Self-Medication Against Gastrointestinal Nematodes: Evidence, Mechanism, And Origins Ẫ†, Juan J. Villalba, James Miller, Eugene D. Ungar, Serge Y. Landau, John Glendinning

Faculty Publications

Gastrointestinal helminths challenge ruminants in ways that reduce their fitness. In turn, ruminants have evolved physiological and behavioral adaptations that counteract this challenge. Ruminants display anorexia and avoidance behaviors, which tend to reduce the incidence of parasitism. In addition, ruminants appear to learn to self-medicate against gastrointestinal parasites by increasing consumption of plant secondary compounds with antiparasitic actions. This selective feeding improves health and fitness. Here, we review the evidence for self-medication in ruminants, propose a hypothesis to explain self-medicative behaviors (based on post-ingestive consequences), and discuss mechanisms (e.g., enhanced neophilia, social transmission) that may underlie the ontogeny and spread …

Evaluation Of Alfalfa Inter-Seeding Effect On Bahiagrass Baleage Fermentation And Lactating Holstein Performance, Michael E. Mccormick, Kun Jun Han, Vinicius R. Moreira, David C. Blouin

Faculty Publications

© 2014 McCormick et al. Background: Previous research indicates that bahiagrass may be successfully conserved as baleage, but nutritive value is typically low for lactating dairy cows. The purpose of this study was to determine the effect of adding modest amounts of alfalfa forage (22%), achieved by inter-seeding alfalfa into an existing bahiagrass pasture, on baleage nutritive value and lactation performance of Holstein cows. Forage treatments employed were monoculture bahiagrass baleage (MBB; negative control), bahiagrass-alfalfa mixture baleage (BAB) and conventional corn silage (CCS; positive control). Thirty six mid lactation Holstein cows [34.8 ± 5.8 kg 3.5% fat-corrected milk and 112 …

Enteric Yaiw Is A Surface-Exposed Outer Membrane Lipoprotein That Affects Sensitivity To An Antimicrobial Peptide, Markus F.F. Arnold, Paola Caro-Hernandez, Karen Tan, Giulia Runti, Silvia Wehmeier, Marco Scocchi, William T. Doerrler, Graham C. Walker, Gail P. Ferguson

Faculty Publications

yaiW is a previously uncharacterized gene found in enteric bacteria that is of particular interest because it is located adjacent to the sbmA gene, whose bacA ortholog is required for Sinorhizobium meliloti symbiosis and Brucella abortus pathogenesis. We show that yaiW is cotranscribed with sbmA in Escherichia coli and Salmonella enterica serovar Typhi and Typhimurium strains. We present evidence that the YaiW is a palmitate-modified surface exposed outer membrane lipoprotein. Since BacA function affects the very-long-chain fatty acid (VLCFA) modification of S. meliloti and B. abortus lipid A, we tested whether SbmA function might affect either the fatty acid modification …

Intellectual Property And Public Health - A White Paper, Ryan Vacca

Faculty Publications

On October 26, 2012, The University of Akron School of Law's Center for Intellectual Property and Technology hosted its Sixth Annual IP Scholars Forum. In attendance were thirteen legal scholars with expertise and an interest in IP and public health who met to discuss problems and potential solutions at the intersection of these fields. This report summarizes this discussion by describing the problems raised, areas of agreement and disagreement between the participants, suggestions and solutions made by participants, and the subsequent evaluations of these suggestions and solutions.

Led by the moderator, participants at the Forum focused generally on three broad …

Antibiotic Lock Therapy: Review Of Technique And Logistical Challenges, Julie Ann Justo, P Brandon Bookstaver

Faculty Publications

Antibiotic lock therapy (ALT) for the prevention and treatment of catheter-related bloodstream infections is a simple strategy in theory, yet its real-world application may be delayed or avoided due to technical questions and/or logistical challenges. This review focuses on these latter aspects of ALT, including preparation information for a variety of antibiotic lock solutions (ie, aminoglycosides, beta-lactams, fluoroquinolones, folate antagonists, glycopeptides, glycylcyclines, lipopeptides, oxazolidinones, polymyxins, and tetracyclines) and common clinical issues surrounding ALT administration. Detailed data regarding concentrations, additives, stability/compatibility, and dwell times are summarized. Logistical challenges such as lock preparation procedures, use of additives (eg, heparin, citrate, or ethylenediaminetetraacetic …

Artemisia Extracts Activate Pparγ, Promote Adipogenesis, And Enhance Insulin Sensitivity In Adipose Tissue Of Obese Mice, Allison J. Richard, Thomas P. Burris, David Sanchez-Infantes, Yongjun Wang, David M. Ribnicky, Jacqueline M. Stephens

Faculty Publications

Objective: Studies have shown that the inability of adipose tissue to properly expand during the obese state or respond to insulin can lead to metabolic dysfunction. Artemisia is a diverse group of plants that has a history of medicinal use. The aim of this study was to examine the ability of ethanolic extracts of Artemisia scoparia (SCO) and Artemisia santolinifolia (SAN) to modulate adipocyte development in cultured adipocytes and white adipose tissue (WAT) function invivo using a mouse model of diet-induced obesity. Method: Adipogenesis was assessed using Oil Red O staining and immunoblotting. A nuclear receptor specificity assay was used …

Myo-Inositol And Phytate Are Toxic To Formosan Subterranean Termites (Isoptera: Rhinotermitidae), Lucas Veillon, Jared Bourgeois, Amanda Leblanc, Gregg Henderson, Brian D. Marx, Syed Muniruzzaman, Roger A. Laine

Faculty Publications

© 2014 Entomological Society of America. Several rare and common monosaccharides were screened for toxic effects on the Formosan subterranean termite, Coptotermes formosanus Shiraki, with the aim of identifying environmentally friendly termiticides. myo-Inositol and phytic acid, which are nontoxic to mammals, were identified as potential termite control compounds. Feeding bioassays with termite workers, where both compounds were supplied on filter paper in concentrations from 160.2 to 1,281.7μg/mm3, showed concentration-dependent toxicity within 2 wk. Interestingly myo-inositol was nontoxic when administered to termites in agar (40 mg/ml) in the absence of a cellulosic food source, an unexplained phenomenon. In addition, decreased populations …

Weight Gain Reveals Dramatic Increases In Skeletal Muscle Extracellular Matrix Remodeling, Charmaine S. Tam, Jeffrey D. Covington, Sudip Bajpeyi, Yourka Tchoukalova, David Burk, Darcy L. Johannsen, Cristina M. Zingaretti, Saverio Cinti, Eric Ravussin

Faculty Publications

Context: In animal models of obesity, chronic inflammation and dysregulated extracellular matrix remodeling in adipose tissue leads to insulin resistance. Whether similar pathophysiology occurs in humans is not clear. Objective: The aim of this study was to test whether 10% weight gain induced by overfeeding triggers inflammation and extracellular matrix remodeling (gene expression, protein, histology) in skeletal muscleandsc adipose tissue in humans.Wealso investigated whether such remodelingwas associated with an impaired metabolic response (hyperinsulinemic-euglycemic clamp). Design, Setting, Participants, and Intervention: Twenty-nine free-living males were fed 40% over their baseline energy requirements for 8 weeks. Results: Ten percent body weight gain prompted …