Digital Commons Network^™

Rare Coding Variants Associated With Blood Pressure Variation In 15 914 Individuals Of African Ancestry, Priyanka Nandakumar, Dongwon Lee, Melissa A. Richard, Fasil Tekola-Ayele, Bamidele O. Tayo, Erin Ware, Yun J. Sung, Babatunde Salako, Adesola Ogunniyi, C. Charles Gu, Megan L. Grove, Myriam Fornage, Sharon Kardia, Charles Rotimi, Richard S. Cooper, Alanna C. Morrison, Georg Ehret, Aravinda Chakravarti

Faculty Publications

Objectives: Hypertension is a major risk factor for all cardiovascular diseases, especially among African Americans. This study focuses on identifying specific blood pressure (BP) genes using 15 914 individuals of African ancestry from eight cohorts (Africa America Diabetes Mellitus, Atherosclerosis Risk in Communities Study, Coronary Artery Risk Development in young Adults, Genetics Network, Genetic Epidemiology Network of Arteriopathy, Howard University Family Study, Hypertension Genetic Epidemiology Network, and Loyola University Chicago Cohort) to further genetic findings in this population which has generally been underrepresented in BP studies. Methods: We genotyped and performed various single variant and gene-based exome-wide analyses on 15 …

Circadian Blood Pressure Variation Amongst People With Chronic Kidney Diseases: A Pilot Study In Ibadan, Abiodun M. Adeoye, Yemi R. Raji, Adewole Adebiyi, Bamidele O. Tayo, Babatunde L. Salako, Adesola Ogunniyi, Akinlolu Ojo, Richard Cooper

Faculty Publications

BACKGROUND: Circadian variation in blood pressure (BP) has been shown to determine cardiovascular events in people with chronic kidney diseases (CKDs). Studies aimed at elucidating the relationship between diurnal variation in BP and cardiovascular disease have yielded conflicting results, and very few of these studies have been conducted on CKD patients in Sub-Saharan Africa, hence the need for this study. SUBJECTS AND METHODS: Eighty-five adult participants comprising 54 patients with CKD (36 males and 18 females) and 31 hypertensive patients (16 males and 15 females) free of CKD were recruited for 24 h ambulatory BP monitoring and cardiovascular risk factor …

Papio Baboon Species Indicative Alu Elements, Mark Batzer, Jerilyn A. Walker, Vallmer E. Jordan, Cody J. Steely, Thomas O. Beckstrom, Cullen L. Mcdaniel, Corey P. St. Romain, Emily C. Bennett, Arianna Robichaux, Brooke N. Clement, Miriam K. Konkel

Faculty Publications

The genus of Papio (baboon) has six recognized species separated into Northern and Southern clades, each comprised of three species distributed across the African continent. Geographic origin and phenotypic variants such as coat color and body size have commonly been used to identify different species. The existence of multiple hybrid zones, both ancient and current, have complicated efforts to characterize the phylogeny of Papio baboons. More recently, mitochondrial DNA (mtDNA) and Y-chromosome genetic markers have been utilized for species identification with particular focus on the hybrid zones. Aluelements accumulate in a random manner and are a novel source of …

Comparing Salinities Of 10, 20, And 30% In Intensive, Commercial-Scale Biofloc Shrimp (Litopenaeus Vannamei) Production Systems, Andrew J. Ray, Jeffrey M. Lotz

Faculty Publications

Minimal-exchange, intensive biofloc aquaculture systems offer a viable means of culturing marine animals at inland locations due to very low rates of water use. Fresh, never-frozen shrimp can be provided to metropolitan markets; however, the cost of artificial salt can be substantial. The purpose of this project was to examine commercial-scale biofloc shrimp production at three different salinities. Nine raceways were randomly assigned to three salinity treatments: 10, 20, and 30‰ (LS, MS, and HS), each treatment contained three raceways operated at 50 m³. The raceways were operated as heterotrophic biofloc systems, with daily additions of sucrose to …

Neutral Genetic Processes Influence Mhc Evolution In Threatened Gopher Tortoises (Gopherus Polyphemus), Jean P. Elbers, Rachel W. Clostio, Sabrina S. Taylor

Faculty Publications

Levels of adaptive genetic variation influence how species deal with environmental and ecological change, but these levels are frequently inferred using neutral genetic markers. Major histocompatibility complex (MHC) genes play a key role in the adaptive branch of the immune system and have been used extensively to estimate levels of adaptive genetic variation. Parts of the peptide binding region, sites where MHC molecules directly interact with pathogen and self-proteins, were sequenced from a MHC class I (95/441 tortoises) and class II (245/441 tortoises) gene in threatened and nonthreatened populations of gopher tortoises (Gopherus polyphemus), and adaptive genetic variation at MHC …

Zebrafish Models In Neuropsychopharmacology And Cns Drug Discovery, Kanza M. Khan, Adam D. Collier, Darya A. Meshalkina, Elana V. Kysil, Sergey L. Khatsko, Tatyana Kolesnikova, Yury Yu Morzherin, Jason E. Warnick, Allan V. Kalueff, David Echevarria

Faculty Publications

Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and …

Remembering The Mighty Acts Of God, Merlin D. Burt

Faculty Publications

No abstract provided.

Revisiting The Compassion Fatigue, Burnout, Compassion Satisfaction, And Resilience Connection Among Cism Responders, Harvey J. Burnett Jr.

Faculty Publications

Previous research by Burnett and Wahl found that resilience moderately mediated the association between compassion fatigue (CF) and burnout (BO) among trauma responders. No studies have attempted to replicate and verify the research results of Burnett and Wahl. This study examined whether similar patterns of resilience, CF, BO, and compassion satisfaction (CS) would be found among a convenience sample of disaster behavioral health (DBH) responders (N = 70) attending an annual Critical Incident Stress Management training conference in Michigan. Measures included the 30-item Professional Quality of Life Scale, the 14-Item Resilience Scale, the Response to Stressful Events Scale, and a …

Individual And Structural Environmental Influences On Utilization Of Iron And Folic Acid Supplementation Among Pregnant Women In Harare, Zimbabwe, Chiwoneso B. Tinago, Lucy Annang Ingram, Christine E. Blake, Edward A. Frongillo Jr.

Faculty Publications

Micronutrient deficiencies are prevalent among Zimbabweans with serious health and social implications. Due to alack of a national micronutrient food fortification policy, the Zimbabwe Ministry of Health and Child Careestablished a policy for the prevention of maternal micronutrient deficiencies, which centres on pregnant womenreceiving daily iron and folic acid (IFA) at theirfirst antenatal care visit and throughout pregnancy. Despite theseefforts, utilization of IFA supplementation in pregnancy in Zimbabwe is low. This study aimed to understand theexperiences and knowledge of IFA supplementation among pregnant women and healthcare workers in Harare,Zimbabwe, and the influence of health-service and social environments on utilization. Semi-structured …

The Pesky Serial Comma, Douglas E. Abrams

Faculty Publications

The "serial comma" - sometimes called the "Oxford comma" or the "Harvard comma"- comes immediately before a conjunction that separates the last of three or more elements in a series. For example, consider the trio "ready, willing, and able." Consider too "win, lose, or draw." The serial comma is the one immediately before the "and" or the "or." In statutes or private arrangements, a comma's presence (or, as in O'Connor, its absence) may hold high stakes for litigants.

Critical Care Nurses’ Suggestions To Improve End-Of-Life Care Obstacles: Minimal Change Over 17 Years, Renea L. Beckstrand, Kacie Hart Hadley, Karlen E. Luthy, Janelle L. B. Macintosh

Faculty Publications

Background: Critical-care nurses (CCNs) provide end-of-life (EOL) care on a daily basis as 1 in 5 patients dies while in intensive care units. Critical-care nurses overcome many obstacles to perform quality EOL care for dying patients.

Objectives: The purposes of this study were to collect CCNs’ current suggestions for improving EOL care and determine if EOL care obstacles have changed by comparing results to data gathered in 1998.

Methods: A 72-item questionnaire regarding EOL care perceptions was mailed to a national, geographically dispersed, random sample of 2000 members of the American Association of Critical-Care Nurses. One of 3 qualitative questions …

Body Esteem And Appearance-Based Self-Worth: A Test Of Religious Moderators In Men And Women, Mary Inman, Charlotte Vanoyen Witvliet

Faculty Publications

Basing self-worth on appearance is inversely related to women’s body esteem, but studies have not examined whether religious factors moderate this relationship in women or men—controlling for positive and negative affect. We tested two possible moderators: basing self-worth on when one has God’s (conditional) love or having positive attitudes toward God (trusting and feeling loved and supported by an all-knowing and all-powerful God). In women (N=287) and men (N=124), correlations showed that basing self-worth on appearance was negatively related to body esteem, whereas positive attitudes toward God were positively related to body esteem. In women, basing self-worth on perceptions of …

We’Ll Never Be Royals, But That Doesn’T Matter, Art Carden, Sarah Estelle, Anne Bradley

Faculty Publications

No abstract provided.

Interpersonal Conflict Among Caribbean Couples In Jamaica, Guyana And The United States, Krim K. Lacey, Letroy O. Cummings, Karen Powell Sears, Niki Matusko, Rohan D. Jeremiah, James S. Jackson

Faculty Publications

No abstract provided.

Capacity Of Blood Plasma Is Higher In Birds Breeding In Radioactively Contaminated Areas, Magdalena Ruiz-Rodríguez, Anders P. Møller, Timothy Mousseau, Juan J. Soler

Faculty Publications

Background Environmental pollution in general, and radioactive contamination in particular, may deeply affect host-parasite relationships and their consequences for the evolution of organisms. The nuclear accident that occurred more than 30 years ago in Chernobyl resulted in significant changes in diversity and richness of microbial communities that could influence characteristics of animal-bacteria interactions, including host immune responses and competitive interference by bacteria. Given the high mortality rate of birds breeding in radioactively contaminated zones, those with stronger defences against infections should experience significant fitness advantages.

Methodology/Principal Findings Here we characterized antimicrobial capacity of barn swallows (Hirundo rustica) from different Ukrainian …

The Relationship Between Motor Competence And Health-Related Fitness In Children And Adolescents, Carlos Luz, Luı´S P. Rodrigues, An V. De Meester, Rita Cordovil

Faculty Publications

Background and aims

In the last twenty years, there has been increasing evidence that Motor Competence (MC) is vital for developing an active and healthy lifestyle. This study analyses the associations between motor competence and its components, with health-related fitness (HRF).

Methods

A random sample of 546 children (278 males, mean = 10.77 years) divided into four age groups (7–8; 9–10; 11–12; 13–14 years old) was evaluated. A quantitative MC instrument (evaluating stability, locomotor and manipulative skills), a maximal multistage 20-m shuttle-run test and the handgrip test, height and BMI were used in the analyses. Pearson correlations and standard regression …

A Study Of Ticks And Tick-Borne Livestock Pathogens In Pakistan, Shahid Karim, Khemraj Budachetri, Nabanita Mukherjee, Jaclyn Williams, Asma Kausar, Muhammad Jawadul Hassan, Steven W. Adamson, Scot E. Dowd, Dmitry Apanskevich, Abdullah Arijo, Zia Uddin Sindhu, Muhammad Azam Kakar, Raja Muhammad Dilpazir Khan, Shafiq Ullah, Muhammad Sohail Sajid, Abid Ali, Zafar Iqbal

Faculty Publications

Background

As obligate blood-feeding arthropods, ticks transmit pathogens to humans and domestic animals more often than other arthropod vectors. Livestock farming plays a vital role in the rural economy of Pakistan, and tick infestation causes serious problems with it. However, research on tick species diversity and tick-borne pathogens has rarely been conducted in Pakistan. In this study, a systematic investigation of the tick species infesting livestock in different ecological regions of Pakistan was conducted to determine the microbiome and pathobiome diversity in the indigenous ticks.

Methodology/Principal findings A total of 3,866 tick specimens were morphologically identified as 19 different tick …

Implications Of Synchronous Ivr Radio On Syrian Refugee Health And Community Dynamics, R. Talhouk, T. Bartindale, K. Montague, S. Mesmar, C. Akik, A. Ghassani, M. Najem, Hala Ghattas Ph.D., P. Olivier, M. Balaam

Faculty Publications

With 1,033,513 Syrian refugees adding a strain on the Lebanese healthcare system, innovation is key to improving access to healthcare. Our previous work identified the potential for technology to improve access to antenatal care services and increase refugee agency. Using (1) paper mock ups and a mobile based prototype, (2) process mapping, (3) focus groups and interviews and (4) key informant meetings, we explored the concept of refugee led community radio shows to deliver peerled healthcare.1We observed the influence of community radio shows on Syrian refugee health education, community dynamics and community agency in relationships between healthcare providers and refugees. …

Galanin-Expressing Gaba Neurons In The Lateral Hypothalamus Modulate Food Reward And Noncompulsive Locomotion, Emily Qualls-Creekmore, Sangho Yu, Marie Francois, John Hoang, Clara Huesing, Annadora Bruce-Keller, David Burk, Hans Rudolf Berthoud, Christopher D. Morrison, Heike Münzberg

Faculty Publications

© 2017 the authors. The lateral hypothalamus (LHA) integrates reward and appetitive behavior and is composed of many overlapping neuronal populations. Recent studies associated LHA GABAergic neurons (LHAGABA), which densely innervate the ventral tegmental area (VTA), with modulation of food reward and consumption; yet, LHAGABA projections to the VTA exclusively modulated food consumption, not reward. We identified a subpopulation of LHA GABA neurons that coexpress the neuropeptide galanin (LHAGal). TheseLHAGal neurons also modulate food reward, but lack direct VTA innervation. We hypothesized that LHAGal neurons may represent a subpopulation of LHAGABA neurons that mediates food reward independent of direct VTA …

Best Practice For Prevention Of Vaccination Common Problems With Antipyretic/Analgesic Medications, Lacey M. Eden, Meridith G. Lind, Karlen E. Luthy, Janelle L. B. Macintosh

Faculty Publications

Nurse practitioners are on the front lines providing parental education regarding vaccines. Some reasons for vaccine hesitancy include the potential common mild problems of vaccine administration, such as pain and/or elevated temperature. According to research, prophylactic administration of an antipyretic/analgesic medication, such as acetaminophen, reduces common mild problems related to vaccines when administered before or at the time of vaccination. Additionally, the evidence that prophylactic administration of antipyretic/analgesic medication decreases antibody response to vaccinations is insufficient at this time. However, this research has led to some confusion on best practice guidelines. This review of the literature resulted in recommendations that …

International Society Of Sports Nutrition Position Stand: Protein And Exercise, Ralf Jäger, Chad M. Kerksick, Bill I. Campbell, Paul J. Cribb, Shawn D. Wells, Tim M. Skwiat, Martin Purpura, Tim N. Ziegenfuss, Arny A. Ferrando, Shawn M. Arent, Abbie E. Smith-Ryan, Jeffrey R. Stout, Paul J. Arciero, Michael J. Ormsbee, Lem W. Taylor, Colin D. Wilborn, Doug S. Kalman, Richard B. Kreider, Darryn S. Willoughby, Jay R. Hoffman, Jamie L. Krzykowski, Jose Antonio

Faculty Publications

Position statement: The International Society of Sports Nutrition (ISSN) provides an objective and critical review related to the intake of protein for healthy, exercising individuals. Based on the current available literature, the position of the Society is as follows:

1) An acute exercise stimulus, particularly resistance exercise, and protein ingestion both stimulate muscle protein synthesis (MPS) and are synergistic when protein consumption occurs before or after resistance exercise.

2) For building muscle mass and for maintaining muscle mass through a positive muscle protein balance, an overall daily protein intake in the range of 1.4–2.0 g protein/kg body weight/day (g/kg/d) is …

Identifying United States And Territory Education Requirements For Childhood Vaccination Exemptions, Lacey M. Eden, Emily G. Dunn, Karlen E. Luthy, Katelyn Wells, Janelle L. B. Macintosh, Renea Beckstrand

Faculty Publications

Background: : Children are required by law to receive vaccinations to enter school. States and territories offer exemptions for parents who refuse to vaccinate their children. Types of exemptions vary by state or territory, as does the exemption filing process. The purpose of this research was to identify the various education-related processes implemented by states and territories which allow parents to exempt children from vaccinations.

Methods: A questionnaire was distributed to immunization program managers in the 50 United States, District of Columbia, the United States Indian Health Service, and eight United States territories. Managers reported vaccination requirements for their jurisdiction …

Subjective Reactions To International Research Participation: An Illustration Of Ethical Considerations With Women Heading Households In Sri Lanka, Jessica E. Lambert, Alyssa Banford Witting, Lakmal Ponnamperuma, Thulitha Wickrama

Faculty Publications

There are unique ethical considerations in conducting international research with war and disaster-affected populations that are important for ensuring adequate protection of participants. Of particular importance is the distress that participants may experience as a result of being asked about traumatic stressors, psychological symptoms, and life problems. In this study, trauma-affected Tamil women in Eastern Sri Lanka were asked to report on their research-participation experience after taking part in a larger study on risk and resiliency. Results indicated that most participants experienced emotional upset as a result of taking part in the study. However, the degree of distress was generally …

The Implications Of Using A Broad Versus Narrow Set Of Criteria In Research, Leonard A. Jason, Kristen D. Gleason Phd, Pamela Fox

Faculty Publications

The Fukuda et al. criteria is the most widely used clinical case definition for diagnosing patients with chronic fatigue syndrome (CFS). Despite the frequency with which the Fukuda criteria are applied, the list of symptoms outlined in this case definition were not well enough specified to be easily applied to research settings. In 2005, Reeves et al. laid out a set of standards for operationalizing the Fukuda definition, specifying scales and cutoff scores for measuring the symptom criteria. This operationalization, often known as the empirical criteria, has been shown to identify an unexpectedly large number of patients, seemingly widening the …

Role Of The Endocannabinoid System And Medical Cannabis, Sabrina Jarvis, Sean Rassmussen, Blaine A. Winters

Faculty Publications

Our bodies produce complex substrates called endocannabinoids, which attach to the endocannabinoid system (ECS) receptors and impact many physiologic processes. Current research on the ECS and cannabis-based medications is accelerating in the presence of continued conflict between federal and state laws. In this article we present a summary of the latest information on the ECS, its receptors, and current research on the cannabis-based medicines and their potential to treat various disease pathologies and medical conditions. Our study includes the latest information on the continued legal ramifications nurse practitioners face in treating patients with these medications.

The Peanut Allergic Patient: Diagnosis, Treatment, And Prevention, Daniel W. Hill, Jane H. Lassetter, Craig Nuttall

Faculty Publications

The prevalence of peanut allergies (PAs) continues to rise through recent decades, despite the best attempts to reverse that trend. PAs are unpredictable and can be life-threatening. Therefore, it is imperative that nurse practitioners (NPs) are fully aware of the most recent guidelines and evidence regarding diagnosis, treatment, and prevention of PAs. This article presents information on the current research in the diagnosis and treatment of PAs as well as the latest guidelines established to prevent PA development. NPs should understand this information, allowing them to provide the best care possible for their patients.

Association Of Alzhemier's Disease With Hepatitis C Among Patients With Bipolar Disorder, Herng-Ching Lin, Sudha Xirasagar, Hsin-Chien Lee, Chung-Chien Huang, Chao-Hung Chen

Faculty Publications

Associations of hepatitis C virus infection with Alzheimer’s disease have not been studied among higher risk, bipolar disorder patients. This population-based case-control study investigated the risks of hepatitis C virus infection among Alzheimer’s disease patients with bipolar disorder in the years preceding their Alzheimer’s disease diagnosis. We used 2000–2013 data from the Longitudinal Health Insurance Database in Taiwan. Among patients with bipolar disorder, 73 were diagnosed with Alzheimer’s disease (cases), who were compared with 365 individuals with bipolar disorder but without Alzheimer’s disease (randomly selected controls matched on sex, age, and index year with cases). Prior claims (before the diagnosis …

Akt3 Is Responsible For The Survival And Proliferation Of Embryonic Stem Cells, Ling Wang, Delun Huang, Zongliang Jiang, Yan Luo, Carol Norris, Ming Zhang, Xiuchun Tian, Young Tang

Faculty Publications

© 2017. Published by The Company of Biologists Ltd. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway plays an important role in regulating cell proliferation, metabolism, and survival. However, the distinct roles of Akt isoforms (Akt1, Akt2, and Akt3) in pluripotent stem cell maintenance are not fully defined. Using mouse embryonic stem cells (ESCs), we show that direct inhibition of Akt activity leads to ESC apoptosis. The Akt3, but not Akt1 or Akt2, activity specifically regulates this effect. Inhibiting Akt3 also leads to a cell cycle arrest at G1 phase. These regulatory roles of Akt3 are dependent on its kinase …

An Ensemble Multilabel Classification For Disease Risk Prediction, Runzhi Li, Wei Liu, Yusong Lin, Hongling Zhao, Chaoyang Zhang

Faculty Publications

It is important to identify and prevent disease risk as early as possible through regular physical examinations. We formulate the disease risk prediction into a multilabel classification problem. A novel Ensemble Label Power-set Pruned datasets Joint Decomposition (ELPPJD) method is proposed in this work. First, we transform the multilabel classification into a multiclass classification. Then, we propose the pruned datasets and joint decomposition methods to deal with the imbalance learning problem. Two strategies size balanced (SB) and label similarity (LS) are designed to decompose the training dataset. In the experiments, the dataset is from the real physical examination records. We …

Dietary Inflammatory Index In Relation To Sub-Clinical Atherosclerosis And Atherosclerotic Vascular Disease Mortality In Older Women, Nicola P. Bondonno, Joshua R. Lewis, Lauren C. Blekkenhorst, Nitin Shivappa, Richard J. Woodman, Catherine P. Bondonno, Natalie C. Ward, James R. Hébert, Peter L. Thompson, Richard L. Prince, Jonathan M. Hodgson

Faculty Publications

Arterial wall thickening, stimulated by low-grade systemic inflammation, underlies many cardiovascular events. As diet is a significant moderator of systemic inflammation, the dietary inflammatory index (DIITM) has recently been devised to assess the overall inflammatory potential of an individual’s diet. The primary objective of this study was to assess the association of the DII with common carotid artery–intima-media thickness (CCA–IMT) and carotid plaques. To substantiate the clinical importance of these findings we assessed the relationship of DII score with atherosclerotic vascular disease (ASVD)-related mortality, ischaemic cerebrovascular disease (CVA)-related mortality and ischaemic heart disease (IHD)-related mortality more. The study was conducted …