Digital Commons Network^™

Association Of Alzhemier's Disease With Hepatitis C Among Patients With Bipolar Disorder, Herng-Ching Lin, Sudha Xirasagar, Hsin-Chien Lee, Chung-Chien Huang, Chao-Hung Chen

Faculty Publications

Associations of hepatitis C virus infection with Alzheimer’s disease have not been studied among higher risk, bipolar disorder patients. This population-based case-control study investigated the risks of hepatitis C virus infection among Alzheimer’s disease patients with bipolar disorder in the years preceding their Alzheimer’s disease diagnosis. We used 2000–2013 data from the Longitudinal Health Insurance Database in Taiwan. Among patients with bipolar disorder, 73 were diagnosed with Alzheimer’s disease (cases), who were compared with 365 individuals with bipolar disorder but without Alzheimer’s disease (randomly selected controls matched on sex, age, and index year with cases). Prior claims (before the diagnosis …

Akt3 Is Responsible For The Survival And Proliferation Of Embryonic Stem Cells, Ling Wang, Delun Huang, Zongliang Jiang, Yan Luo, Carol Norris, Ming Zhang, Xiuchun Tian, Young Tang

Faculty Publications

© 2017. Published by The Company of Biologists Ltd. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway plays an important role in regulating cell proliferation, metabolism, and survival. However, the distinct roles of Akt isoforms (Akt1, Akt2, and Akt3) in pluripotent stem cell maintenance are not fully defined. Using mouse embryonic stem cells (ESCs), we show that direct inhibition of Akt activity leads to ESC apoptosis. The Akt3, but not Akt1 or Akt2, activity specifically regulates this effect. Inhibiting Akt3 also leads to a cell cycle arrest at G1 phase. These regulatory roles of Akt3 are dependent on its kinase …

An Ensemble Multilabel Classification For Disease Risk Prediction, Runzhi Li, Wei Liu, Yusong Lin, Hongling Zhao, Chaoyang Zhang

Faculty Publications

It is important to identify and prevent disease risk as early as possible through regular physical examinations. We formulate the disease risk prediction into a multilabel classification problem. A novel Ensemble Label Power-set Pruned datasets Joint Decomposition (ELPPJD) method is proposed in this work. First, we transform the multilabel classification into a multiclass classification. Then, we propose the pruned datasets and joint decomposition methods to deal with the imbalance learning problem. Two strategies size balanced (SB) and label similarity (LS) are designed to decompose the training dataset. In the experiments, the dataset is from the real physical examination records. We …

International Society Of Sports Nutrition Position Stand: Diets And Body Composition, Alan A. Aragon, Brad J. Schoenfeld, Robert Wildman, Susan Kleiner, Trisha Vandusseldorp, Lem Taylor, Conrad P. Earnest, Paul J. Arciero, Colin Wilborn, Douglas S. Kalman, Jeffrey R. Stout, Darryn S. Willoughby, Bill Campbell, Shawn M. Arent, Laurent Bannock, Abbie E. Smith-Ryan, Jose Antonio

Faculty Publications

Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature regarding the effects of diet types (macronutrient composition; eating styles) and their influence on body composition. The ISSN has concluded the following. 1) There is a multitude of diet types and eating styles, whereby numerous subtypes fall under each major dietary archetype. 2) All body composition assessment methods have strengths and limitations. 3) Diets primarily focused on fat loss are driven by a sustained caloric deficit. The higher the baseline body fat level, the more aggressively the caloric deficit …

Dietary Inflammatory Index In Relation To Sub-Clinical Atherosclerosis And Atherosclerotic Vascular Disease Mortality In Older Women, Nicola P. Bondonno, Joshua R. Lewis, Lauren C. Blekkenhorst, Nitin Shivappa, Richard J. Woodman, Catherine P. Bondonno, Natalie C. Ward, James R. Hébert, Peter L. Thompson, Richard L. Prince, Jonathan M. Hodgson

Faculty Publications

Arterial wall thickening, stimulated by low-grade systemic inflammation, underlies many cardiovascular events. As diet is a significant moderator of systemic inflammation, the dietary inflammatory index (DIITM) has recently been devised to assess the overall inflammatory potential of an individual’s diet. The primary objective of this study was to assess the association of the DII with common carotid artery–intima-media thickness (CCA–IMT) and carotid plaques. To substantiate the clinical importance of these findings we assessed the relationship of DII score with atherosclerotic vascular disease (ASVD)-related mortality, ischaemic cerebrovascular disease (CVA)-related mortality and ischaemic heart disease (IHD)-related mortality more. The study was conducted …

Changes In The Policy Environment For Infant And Young Child Feeding In Vietnam, Bangladesh, And Ethiopia, And The Role Of Targeted Advocacy, Jody Harris, Edward A. Frongillo Jr., Phuong H. Nguyen, Sunny S. Kim, Purnima Menon

Faculty Publications

Background

There is limited literature examining shifts in policy environments for nutrition and infant and young child feeding (IYCF) over time, and on the potential contribution of targeted advocacy to improved policy environments in low- and middle-income countries. This study tracked changes in the policy environment over a four-year period in three countries, and examined the role of targeted nutrition and IYCF advocacy strategies by a global initiative.

Methods

Qualitative methods, including key informant interviews, social network mapping, document and literature review, and event tracking, were used to gather data on nutrition and IYCF policies and programs, actor networks, and …

Intersectionality Between Happiness And Well-Being: A Pilot Study Project In A Midwestern University, Belinda A. Creighton-Smith, Junu Shrestha, Thomas M. Flack, Theodora Merle Jn Baptiste

Faculty Publications

This pilot study measures the possible intersectionality of happiness and well-being. Items were used from the Oxford Happiness and Well-Being Questionnaire, designed to independently measure the constructs of happiness and well-being. 42 items were combined from which 10 items were randomly selected and converted to a six-point Likert scale ranging from “strongly disagree” to “strongly agree” and administered to 28 college students at a Midwestern University taking a leisure studies course. The instrument yielded a significant alpha value of α (27) = 0.835. Factor analysis was conducted to find which variable loaded on each factor (happiness and well-being). Items having …

Sedentary Behavior Research Network (Sbrn) – Terminology Consensus Project Process And Outcome, Mark S. Tremblay, Salomé Aubert, Joel D. Barnes, Travis J. Saunders, Valerie Carson, Amy E. Latimer-Cheung, Sabastien F.M. Chastin, Teatske M. Altenburg, Mai J.M. Chinapaw, Neil E. Peterson

Faculty Publications

Background

The prominence of sedentary behavior research in health science has grown rapidly. With this growth there is increasing urgency for clear, common and accepted terminology and definitions. Such standardization is difficult to achieve, especially across multi-disciplinary researchers, practitioners, and industries. The Sedentary Behavior Research Network (SBRN) undertook a Terminology Consensus Project to address this need.

Method

First, a literature review was completed to identify key terms in sedentary behavior research. These key terms were then reviewed and modified by a Steering Committee formed by SBRN. Next, SBRN members were invited to contribute to this project and interested participants reviewed …

Toxoplasma Gondii Moderates The Association Between Multiple Folate-Cycle Factors And Cognitive Function In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges

Faculty Publications

Toxoplasma gondii (T. gondii) is a microscopic, apicomplexan parasite that can infect muscle or neural tissue, including the brain, in humans. While T. gondii infection has been associated with changes in mood, behavior, and cognition, the mechanism remains unclear. Recent evidence suggests that T. gondii may harvest folate from host neural cells. Reduced folate availability is associated with an increased risk of neurodevelopmental disorders, neurodegenerative diseases, and cognitive decline. We hypothesized that impairment in cognitive functioning in subjects seropositive for T. gondii might be associated with a reduction of folate availability in neural cells. We analyzed data from the third …

Karamojong Adolescents In Tororo District, Uganda: Life Events, Adjustment Problems, And Protective Factors, Natalie D. Eggum-Wilkens, Linlin Zhang, Flora Farago

Faculty Publications

The Karamojong people of Uganda are marginalized and likely to have difficult lives. Research is needed to understand Karamojong children’s challenges, adjustment, and resiliency to help guide interventions and policies to improve their lives. Thus, 18 Karamojong 10–16-year-olds (10 girls; M = 13.33 years; SD = 1.81) were recruited from a nongovernmental organization in Tororo District, Uganda, and interviewed about their life events, coping strategies, social support, and hope. Adolescents also were verbally administered questionnaires about their life events and adjustment problems. Participants reported many negative life events (M = 9.28 of 16). The number of negative life events was …

Anise Oil Dosage And Its Effect On Growth Performance And Jejunal Lesions During A Clostridium Perfringens Challenge In Battery Trials, And Growth Performance In A Floor Pen Trial, J. W. Charal, T. D. Bidner, L. L. Southern, M. E. Janes, M. E. Gutierrez, T. A. Lavergne

Faculty Publications

© 2017 Poultry Science Association Inc. Anise oil (AO) is a phytochemical with antibiotic properties and it reduces the growth of Clostridium perfringens in vitro, which is the main causal agent of necrotic enteritis. A series of battery experiments was conducted to determine an AO dosage to feed to broilers and its effect during 2 C. perfringens challenges, and a floor pen experiment to determine its effect in performance. Anise oil linearly reduced (P < 0.05) ADFI and ADG, but feeding broilers 500 to 2,000 mg/kg of AO resulted in similar performance with positive control (PC) fed broilers. Broilers were challenged on d 10 (Experiment 2) or on d 10 and 13 (Experiment 3). Broilers fed AO had lower (P < 0.05) ADFI and ADG compared with broilers fed PC from zero to 18 d (Experiment 2). Growth performance of broilers fed AO was not affected (P > 0.05) during Experiment 3. In both challenges, the jejunum of broilers fed AO had fewer and milder (P < 0.05) lesions compared with broilers fed PC or negative control (NC) diets. In a floor pen trial, 1,000 mg/kg of AO was fed to broilers from zero to 42 days. Broilers fed AO or PC had similar (P > 0.10) growth performance for the entire trial. Broilers …

Intramuscular Immunization Of Mice With The Live-Attenuated Herpes Simplex Virus 1 Vaccine Strain Vc2 Expressing Equine Herpesvirus 1 (Ehv-1) Glycoprotein D Generates Anti-Ehv-1 Immune Responses In Mice, Shiliang A. Liu, Brent A. Stanfield, Vladimir N. Chouljenko, Shan Naidu, Ingeborg Langohr, Fabio Del Piero, Jacqueline Ferracone, Alma A. Roy, Konstantin G. Kousoulas

Faculty Publications

© 2017 American Society for Microbiology. All Rights Reserved. Vaccination remains the best option to combat equine herpesvirus 1 (EHV-1) infection, and several different strategies of vaccination have been investigated and developed over the past few decades. Herein, we report that the liveattenuated herpes simplex virus 1 (HSV-1) VC2 vaccine strain, which has been shown to be unable to enter into neurons and establish latency in mice, can be utilized as a vector for the heterologous expression of EHV-1 glycoprotein D (gD) and that the intramuscular immunization of mice results in strong antiviral humoral and cellular immune responses. The VC2-EHV-1-gD …

Peg3 Control On The Mammalian Msl Complex, An Ye, Hana Kim, Joomyeong Kim

Faculty Publications

©2017 Ye et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Peg3 (paternally expressed gene 3) encodes a DNA-binding protein that functions as a transcriptional repressor. Recent studies revealed that PEG3 binds to Msl1 (male-specific lethal 1) and Msl3, the two main components of the MSL complex. In the current study, we investigated potential roles of Peg3 in controlling its downstream genes through H4K16ac, the histone modification by the MSL complex. According to …

Investigation Of Pseudomonas Fluorescens Strain 3jw1 On Preventing And Reducing Aflatoxin Contaminations In Peanuts, Xiaona Yang, Qi Zhang, Zhi Yuan Chen, Hongxia Liu, Peiwu Li

Faculty Publications

Pseudomonas fluorescens strain 3JW1, which has a broad-spectrum antimicrobial activity, was studied to investigate whether it affects the amounts of aflatoxin B1 (AFB1) produced by Aspergillus flavus. It was found that the bacterium reduced the amounts of AFB1 in potato dextrose broth (PDB) and peanut medium by 97.8% and 99.4%, respectively. It also reduced AFB1 by ~183 μg/kg (55.8%) when applied onto peanut kernels. This strain reduced AFB1 via three mechanisms. First, it significantly inhibited A. flavus growth; second, our data showed that strain 3JW1 inhibits aflatoxin biosynthesis by A. flavus; and third, P. fluorescens strain 3JW1 is capable of …

Short Communication: Sensory Analysis Of A Kefir Product Designed For Active Cancer Survivors, K. O'Brien, C. Boeneke, W. Prinyawiwatkul, J. Lisano, D. Shackelford, K. Reeves, M. Christensen, R. Hayward, K. Carabante Ordonez, L. K. Stewart

Faculty Publications

Kefir is a fermented milk product that is a good source of protein and health-promoting bacteria. It has the potential to improve recovery from exercise and the health and well-being of cancer survivors. The purpose of this study was to explore cancer survivor attitudes about and acceptance of a kefir recovery beverage made from cultured milk, whole fruit, natural sweeteners, and other natural ingredients. Kefir was made by inoculating and fermenting milk with kefir grains. The kefir was then mixed with a fruit base and given to cancer survivors (n = 52) following a bout of exercise. Participants evaluated the …

Causal Effect Of Plasminogen Activator Inhibitor Type 1 On Coronary Heart Disease, Ci Song, Stephen Burgess, John D. Eicher, Christopher J. O'Donnell, Andrew D. Johnson, Jie Huang, Maria Sabater-Lleal, Folkert W. Asselbergs, David Tregouet, So Youn Shin, Jingzhong Ding, Jens Baumert, Tiphaine Oudot-Mellakh, Lasse Folkersen, Nicholas L. Smith, Scott M. Williams, Mohammad A. Ikram, Marcus E. Kleber, Diane M. Becker, Vinh Truong, Josyf C. Mychaleckyj, Weihong Tang, Qiong Yang, Bengt Sennblad, Jason H. Moore, Frances M.K. Williams, Abbas Dehghan, Günther Silbernagel, Elisabeth M.C. Schrijvers, Shelly Smith, Mahir Karakas, Geoffrey H. Tofler, Angela Silveira

Faculty Publications

Background--Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of coronary heart disease (CHD). However, it is unclear whether the association reflects a causal influence of PAI-1 on CHD risk. Methods and Results--To evaluate the association between PAI-1 and CHD, we applied a 3-step strategy. First, we investigated the observational association between PAI-1 and CHD incidence using a systematic review based on a literature search for PAI-1 and CHD studies. Second, we explored the causal association between PAI-1 and CHD …

Bed Bugs And Hotels: Traveler Insights And Implications For The Industry, Jerrod M. Penn, Hannah J. Penn, Michael F. Potter, Wuyang Hu

Faculty Publications

No abstract provided.

Papio Baboon Species Indicative Alu Elements, Jerilyn A. Walker, Vallmer E. Jordan, Cody J. Steely, Thomas O. Beckstrom, Cullen L. Mcdaniel, Corey P. St Romain, Emily C. Bennett, Arianna Robichaux, Brooke N. Clement, Miriam K. Konkel, Mark A. Batzer, Jeffrey Rogers, R. Alan Harris, Muthuswamy Raveendran, Yue Liu, Shwetha Murali, Tauras P. Vilgalys, Jerilyn A. Walker

Faculty Publications

© The Author(s) 2017. The genus of Papio (baboon) has six recognized species separated into Northern and Southern clades, each comprised of three species distributed across the African continent. Geographic origin and phenotypic variants such as coat color and body size have commonly been used to identify different species. The existence ofmultiple hybrid zones, both ancient and current, have complicated efforts to characterize the phylogeny of Papio baboons. More recently, mitochondrial DNA (mtDNA) and Y-chromosome genetic markers have been utilized for species identification with particular focus on the hybrid zones. Alu elements accumulate in a random manner and are a …

Syntheses And Pdt Activity Of New Mono- And Di-Conjugated Derivatives Of Chlorin E6, Hui Chen, Stewart W. Humble, R. G.Waruna Jinadasa, Zehua Zhou, Alex L. Nguyen, M. Graça H. Vicente, Kevin M. Smith

Faculty Publications

© 2017 World Scientific Publishing Company. Syntheses of three new chlorin e6 conjugates for PDT of tumors are reported. One of the new compounds 17 is conjugated with lysine at the 131-position, but the others are mono-conjugated 14 or diconjugated 15 with the non-amino acid species ethanolamine. Cellular experiments with the three new compounds and previously synthesized non-amino acid 152-conjugates (7-10), 131-monoconjugates 14, 16, and a 131,152-diconjugate 12 are reported. In vitro cytotoxicity experiments show that the 131-conjugates are more toxic than the 152-conjugates, and the most toxic derivative (dark- and photo-toxicity) is the 131-ethylenediamine conjugate 11. The most useful …

The Characteristics Of Interpersonal Networks In Disaster Response*, Christopher Kenny, Christopher Weber, Kathleen Bratton

Faculty Publications

It is well established that discussion networks have meaningful consequences for a variety of sociopolitical attitudes and behavior. In this project, we explore how social structure shapes reactions to disaster; in particular, the 2010 BP oil spill. We address the questions of how networks are relied upon following community-wide disaster, and to what extent these networks mirror social structures in other domains. To examine these questions, we analyze data that experimentally vary the commonly employed discussion “name-generator” questions to see if oil spill discussants are fundamentally different from important matters discussants. Relative to “important matters” discussants, we find strong support …

Anti-Microbial Effects Of Conductive Copper Nanoparticle Film, Daniel Parrott, Kevin M. Ringelman, Michael S. Chaussee

Faculty Publications

Novel infection control methods are needed to prevent further increases in the morbidity and mortality associated with hospital acquired infections. One method is to minimize bacterial transmission is to prevent bacterial growth on hospital surfaces. Copper has anti-microbial properties but is used sparingly in health care settings due to the cost associated with retrofitting surfaces with copper sheet metal or less durable foil. However, copper nanoparticles (CNPs) embedded in a polymer matrix may be similarly anti-microbial, which would offer a viable alternative to copper metal. In this pilot study, we created films with various densities of CNPs and tested their …

A Comparison Of Two Insect Collection Techniques In Oiled And Non-Oiled Salt Marshes In Louisiana, Benjamin J. Adams, Xuan Chen, Linda M. Hooper-Bùi

Faculty Publications

Insects are important components in coastal marsh ecosystems and can be used as an indicator of marsh health. Collections of insects in coastal marshes are usually made using either sweep nets or insect vacuums. Differences in these 2 methods have not been compared within the marsh ecosystem. Therefore, we compared collections made using these methods in oiled and non-oiled marshes along multiple transects on the Louisiana coast. We found that sweep net collections accounted for 5.9 times more individual arthropods and more total insect taxa when compared with the insect vacuum collections. Oiled marshes had greater total insect richness but …

Preadolescent Sensation Seeking And Early Adolescent Stress Relate To At-Risk Adolescents' Substance Use By Age 15, Nora E. Charles, Charles W. Mathias, Ashley Acheson, Donald M. Dougherty

Faculty Publications

Background and aims

Substance use during adolescence can lead to the development of substance use disorders and other psychosocial problems. These negative outcomes are especially likely for individuals who use substances at earlier ages and those who engage in heavier use during adolescence, behaviors which are both more common among youth at higher risk for developing a substance use disorder, such as those with a family history of substance use disorders (FH +). Factors such as increased sensation seeking and greater exposure to stressors among FH + youth may influence these associations. Therefore, the aim of this study was to …

Effect Of Cohorts On Student Retention In Engineering, Patricia Backer, Cindy Kato

Faculty Publications

Project Succeed is a campus-wide initiative funded by the U.S. Department of Education. Its focus is to improve the 5-year graduation and retention rates and close the achievement gap for Under-Represented Minorities (URMs) across all majors at San José State University (SJSU). There are three major goals: strengthen SJSU’s core academic performance in retention and graduation; provide an improved supportive environment for URM students; and enhance the delivery and integration of academic and co-curricular support services. For Fall 2015, newly matriculated students in the College of Business, College of Engineering, and Child and Adolescent Development Department (CHAD) were assigned schedules …

Judicial Fact-Finding In An Age Of Rapid Change: Creative Reforms From Abroad, Allison Orr Larsen

Faculty Publications

No abstract provided.

Faculty Led Study Abroad: Influences On Student Intercultural Communication, Interprofessional Attitudes, And Professional Identity, Lynne Andonian, Ruth Rosenblum

Faculty Publications

Interprofessional education is valued within healthcare professional programs as reflected in accreditation standards and program outcomes as well as college-wide initiatives. Little is known about the relationships between interprofessional attitudes among healthcare students (nursing, occupational therapy, social work), their degree of intercultural communication skills, and their professional identity. Thirty three students participating in interprofessional faculty-led study abroad completed pre- and postmeasures of the constructs under study: interprofessional attitudes, intercultural communication, and professional identity. Statistically significant positive relationships were found between interprofessional attitudes and intercultural communication skills which are discussed as well as implications for education and practice. This quantitative, descriptive …

Weather And Children’S Physical Activity; How And Why Do Relationships Vary Between Countries?, Flo Harrison, Anna Goodman, Ester M.F. Van Sluijs, Lars Bo Carson, Greet Cardon, Rachel Davey, Kathleen F. Janz, Susi Kriemler, Lynn Molly, Angie S. Page, Russell R. Pate, Jardena J. Puder, Luis B. Sardinha, Anna Timperio, Niels Wedderkopp, Andy P. Jones

Faculty Publications

Background

Globally most children do not engage in enough physical activity. Day length and weather conditions have been identified as determinants of physical activity, although how they may be overcome as barriers is not clear. We aim to examine if and how relationships between children’s physical activity and weather and day length vary between countries and identify settings in which children were better able to maintain activity levels given the weather conditions they experienced.

Methods

In this repeated measures study, we used data from 23,451 participants in the International Children’s Accelerometry Database (ICAD). Daily accelerometer-measured physical activity (counts per minute; …

A Higher Dietary Inflammatory Index Score Is Associated With A Higher Risk Of Breast Cancer Among Chinese Women: A Case–Control Study, Wu-Qing Huang, Xiong-Fei Mo, Yan-Bing Ye, Nitin Shivappa, Fang-Yu Lin, Jing Huang, James R. Hébert, Bo Yan, Cai-Xia Zhang

Faculty Publications

Previous studies have investigated the association between dietary inflammatory potential and the development of cancer. For breast cancer the results have been equivocal. The present study aimed to investigate whether higher Dietary Inflammatory IndexTM (DII) scores were associated with increased risk of breast cancer among Chinese women. A total of 867 cases and 824 controls were recruited into the present case–control study from September 2011 to February 2016. DII scores were computed based on baseline dietary intake assessed by a validated 81-item FFQ. The OR and 95 % CI were assessed by multivariable logistic regression after adjusting for various potential …

Microbial Extracellular Polymeric Substances (Epss) In Ocean Systems, Alan W. Decho, Tony Gutierrez

Faculty Publications

Microbial cells (i.e., bacteria, archaea, microeukaryotes) in oceans secrete a diverse array of large molecules, collectively called extracellular polymeric substances (EPSs) or simply exopolymers. These secretions facilitate attachment to surfaces that lead to the formation of structured ‘biofilm’ communities. In open-water environments, they also lead to formation of organic colloids, and larger aggregations of cells, called ‘marine snow.’ Secretion of EPS is now recognized as a fundamental microbial adaptation, occurring under many environmental conditions, and one that influences many ocean processes. This relatively recent realization has revolutionized our understanding of microbial impacts on ocean systems. EPS occur in a range …

Predicting Cryptic Links In Host-Parasite Networks, Tad Dallas, Andrew W. Park, John M. Drake

Faculty Publications

Networks are a way to represent interactions among one (e.g., social networks) or more (e.g., plant-pollinator networks) classes of nodes. The ability to predict likely, but unobserved, interactions has generated a great deal of interest, and is sometimes referred to as the link prediction problem. However, most studies of link prediction have focused on social networks, and have assumed a completely censused network. In biological networks, it is unlikely that all interactions are censused, and ignoring incomplete detection of interactions may lead to biased or incorrect conclusions. Previous attempts to predict network interactions have relied on known properties of network …