Digital Commons Network^™

Catalase Is A Determinant Of The Colonization And Transovarial Transmission Of Rickettsia Parkeri In The Gulf Coast Tick Amblyomma Maculatum, Khemraj Budachetri, Deepak Kumar, Shahid Karim

Faculty Publications

The Gulf Coast tick (Amblyomma maculatum) has evolved as a competent vector of the spotted‐fever group rickettsia, Rickettsia parkeri. In this study, the functional role of catalase, an enzyme responsible for the degradation of toxic hydrogen peroxide, in the colonization of the tick vector by R. parkeri and transovarial transmission of this pathogen to the next tick generation, was investigated. Catalase gene (CAT) expression in midgut, salivary glands and ovarian tissues exhibited a 2–11‐fold increase in transcription level upon R. parkeri infection. Depletion of CAT transcripts using an RNA‐interference approach significantly reduced R. parkeri infection …

Lack Of Spatial Resilience In A Recovery Process: Case L'Aquila, Italy, Diana Contreras, Thomas Blaschke, Michael E. Hodgson

Faculty Publications

The lack of coordination between government agencies, involvement of the collaboration networks existing in the community, and incorporation of spatial planning in the location of the new settlements around L'Aquila (Italy) after the 2009 earthquake has delayed reconstruction of the city centre. The displaced population was relocated to 19 new settlements. These new settlements are characterized by a lack of urban facilities. The aim of this paper was to analyze the relationship between urban facilities, collaboration networks and lack of spatial resilience in the recovery process in L'Aquila. Specifically, we focused on the preferences of inhabitants to search for alternative …

Religiosity And Chastity Among Single Young Adults And Married Adults, Sam A. Hardy, Brian J. Willoughby

Faculty Publications

The purpose of the present study was to present theological, philosophical, and psychological arguments for chastity as a virtue, and then test an empirical model linking religiosity to outcomes by way of values about chastity. Specifically, we tested a mediation model linking religiosity to outcomes via chastity values (beliefs about the importance of waiting until marriage to have sex and importance of sex within marriage as a bonding experience). This model was tested with a sample of single young adults (4,188) and a sample of married adults (2,531). Among single young adults, religiosity positively predicted abstinence beliefs, and abstinence beliefs …

Stable Isotopes And Radiocarbon Assess Variable Importance Of Plants And Fungi In Diets Of Arctic Ground Squirrels, Erik A. Hobbie, Julee Shamhart, Michael Sheriff, Andrew P. Ouimette, Matt Trappe, Edward A. G. Schuur, John E. Hobbie, Rudy Boonstra, Brian M. Barnes

Faculty Publications

Arctic ground squirrels (Urocitellus parryii) rely primarily on dietary protein derived from plants to fuel gluconeogenesis during hibernation, yet fungal sporocarps may be an important, yet overlooked, protein source. Fungivory levels depend on sporocarp productivity, which varies with the dominant plant species and is higher on acidic than on non-acidic soils. To test whether these factors altered fungal consumption, we used stable isotopes to investigate arctic ground squirrel diets at two sites in northern Alaska, Toolik (primarily moist acidic tundra) and Atigun (primarily moist non-acidic tundra). Radiocarbon estimates can also indicate fungivory levels because ectomycorrhizal fungi assimilate soil-derived organic nitrogen …

Patient Or Physician Centered Care?: Structural Implications For Clinical Interactions And The Overlooked Patient, Aaron B. Franzen

Faculty Publications

Patient-centered care is widely supported by physicians, but this wide-spread support potentially obscures the social patterning of clinical interactions. We know that patients often want religious/spiritual conversations in the context of medical care but the provision is infrequent. As there is regional variance in religiosity, a gap in the literature exists regarding whether patient populations’ religiosity is connected to physicians’ self-reported religious/spiritual interactions. Using a national sample of U.S. physicians linked to county-level measures, the author test whether both physicians’ background and patient population characteristics are related to religious/spiritual interactions. Specifically, do physicians in more religious locations report more frequent …

Restroom Use, Civil Rights, And Free Speech "Opportunism", Timothy Zick

Faculty Publications

Commentators have expressed concerns that litigants are invoking the First Amendment's Free Speech Clause strategically, in order to compensate for the weakness or futility of other constitutional claims. The phenomenon has been given a label- "opportunism "-and scholars have examined some of its causes and consequences. This Article takes a closer and somewhat skeptical look at the concept offree speech "opportunism." It imagines that the Free Speech Clause will be invoked in challenges to laws or policies that restrict public restroom use based on a person's gender. Would such challenges be "opportunistic, " as the term has been defined? What …

Financial Success From The Start: Personal Finance For New Pastors, Annetta M. Gibson

Faculty Publications

Presentation for the Mid-America Union Conference Pastor's Convention, July 31, 2017

An Ensemble Deep Convolutional Neural Network Model With Improved D-S Evidence Fusion For Bearing Fault Diagnosis, Shaobo Li, Guokai Liu, Xianghong Tang, Jianguang Lu, Jianjun Hu

Faculty Publications

Intelligent machine health monitoring and fault diagnosis are becoming increasingly important for modern manufacturing industries. Current fault diagnosis approaches mostly depend on expert-designed features for building prediction models. In this paper, we proposed IDSCNN, a novel bearing fault diagnosis algorithm based on ensemble deep convolutional neural networks and an improved Dempster–Shafer theory based evidence fusion. The convolutional neural networks take the root mean square (RMS) maps from the FFT (Fast Fourier Transformation) features of the vibration signals from two sensors as inputs. The improved D-S evidence theory is implemented via distance matrix from evidences and modified Gini Index. Extensive evaluations …

Complete Genome Sequence Of Vibrio Gazogenes Atcc 43942, Phani M. Gummadidala, Michael E. Holder, Jacqueline L. O’Brien, Nadim J. Ajami, Joseph F. Petrosino, Chandrani Mitra, Yung Pin Chen, Alan W. Decho, Anindya Chandaa

Faculty Publications

Vibrio gazogenes ATCC 43942 has the potential to synthesize a plethora of metabolites which are of clinical and agricultural significance in response to environmental triggers. The complete genomic sequence of Vibrio gazogenes ATCC 43942 is reported herein, contributing to the knowledge base of strains in the Vibrio genus.

Understanding Differences Between Summer Vs. School Obesogenic Behaviors Of Children: The Structured Days Hypothesis, Keith Brazendale, Michael W. Beets, R. Glenn Weaver, Russell R. Pate, Gabrielle Turner-Mcgrievy, Andrew T. Kaczynski, Jessica L. Chandler, Amy Bohnert, Paul T. Von Hippel

Faculty Publications

Background: Although the scientific community has acknowledged modest improvements can be made to weight status and obesogenic behaviors (i.e., physical activity, sedentary/screen time, diet, and sleep) during the school year, studies suggests improvements are erased as elementary-age children are released to summer vacation. Emerging evidence shows children return to school after summer vacation displaying accelerated weight gain compared to the weight gained occurring during the school year. Understanding how summer days differ from when children are in school is, therefore, essential.

Discussion: There is limited evidence on the etiology of accelerated weight gain during summer, with few studies comparing obesogenic …

An Advanced Multi-Sensor Acousto-Ultrasonic Structural Health Monitoring System: Development And Aerospace Demonstration, Joel Smithard, Nik Rajic, Stephen Van Der Velden, Patrick Norman, Cedric Rosalie, Steve Galea, Hanfei Mei, Bin Lin, Victor Giurgiutiu

Faculty Publications

A key longstanding objective of the Structural Health Monitoring (SHM) research community is to enable the embedment of SHM systems in high value assets like aircraft to provide on-demand damage detection and evaluation. As against traditional non-destructive inspection hardware, embedded SHM systems must be compact, lightweight, low-power and sufficiently robust to survive exposure to severe in-flight operating conditions. Typical Commercial-Off-The-Shelf (COTS) systems can be bulky, costly and are often inflexible in their configuration and/or scalability, which militates against in-service deployment. Advances in electronics have resulted in ever smaller, cheaper and more reliable components that facilitate the development of compact and …

Does Fathers' Involvement In Services Affect Mothers' Likelihood Of Reunification With Children Placed In Foster Care?, Amy D'Andrade

Faculty Publications

Social science literature shows associations between fathers' involvement with their children and beneficial developmental outcomes of those children. A related but smaller body of research in the child welfare services arena has found measures of father involvement to be positively associated with beneficial child welfare outcomes, including child's reunification with parent after placement in foster care. However, the pathway by which father involvement affects reunification likelihood has not been determined. This study builds on the existing body of literature by testing a theoretical basis for the relationship between father involvement (measured as service use) and mothers' reunification in a model …

An Advanced Multi-Sensor Acousto-Ultrasonic Structural Health Monitoring System: Development And Aerospace Demonstration, Joel Smithard, Nik Rajic, Stephen Van Der Velden, Patrick Norman, Cedric Rosalie, Steve Galea, Hanfei Mei, Bin Li, Victor Giurgiutiu

Faculty Publications

A key longstanding objective of the Structural Health Monitoring (SHM) research community is to enable the embedment of SHM systems in high value assets like aircraft to provide on-demand damage detection and evaluation. As against traditional non-destructive inspection hardware, embedded SHM systems must be compact, lightweight, low-power and sufficiently robust to survive exposure to severe in-flight operating conditions. Typical Commercial-Off-The-Shelf (COTS) systems can be bulky, costly and are often inflexible in their configuration and/or scalability, which militates against in-service deployment. Advances in electronics have resulted in ever smaller, cheaper and more reliable components that facilitate the development of compact and …

Custom 3d Printer And Resin For 18 Μm × 20 Μm Mi- Crofluidic Flow Channels, Hua Gong, Bryce P. Bickham, Adam T. Woolley, Gregory P. Nordin

Faculty Publications

While there is great interest in 3D printing for microfluidic device fabrication, to-date the achieved feature sizes have not been in the truly microfluidic regime (μm). In this paper we demonstrate that a custom Digital Light Processor stereolithographic (DLP-SLA) 3D printer and a specifically-designed, low cost, custom resin can readily achieve flow channel cross sections as small as 18 μm × 20 μm. Our 3D printer has a projected image plane resolution of 7.6 μm and uses a 385 nm LED, which dramatically increases the available selection of UV absorbers for resin formulation compared to 3D printers with 405 nm …

Evaluation Of Crude Larval Protein And Recombinant Somatic Protein 26/23 (Rhcp26/23) Immunization Against Haemonchus Contortus In Sheep, Omnia M. Kandil, Khaled A. Abdelrahman, Hatem A. Shalaby, Seham H.M. Hendawy, Nadia M.T. Abu El Ezz, Somia A. Nassar, James E. Miller

Faculty Publications

© Kandil, et al. Aim: The aim of this study was to evaluate the potential possibility of crude larval and recombinant (rHcp26/23) antigens of Haemonchus contortus for immunization to control sheep hemonchosis. Materials and Methods: A total of 21 lambs were divided into five groups. Lambs were immunized with larval and recombinant (rHcp26/23) proteins at day 0 and day 14 and after that challenged with 5000 infective larvae of H. contortus on day 42. An unvaccinated positive control group was challenged with L3 in the meantime. An unvaccinated negative control group was not challenged. Results: Fecal egg count reduction taking …

Should Nurse Practitioners Be Required To Record Immunizations In Immunization Information Systems?, Donald Gardenier, Lacey Eden, Karlen E. (Beth) Luthy

Faculty Publications

The United States Centers for Disease Control and Prevention (CDC)’s Vaccines for Children (VFC) Program, which provides the majority of childhood immunizations, has been in existence for over 20 years. The CDC also created the Immunization Information Systems (IIS) program in which states were allocated funding to create statewide immunization databases. The goal was to maintain a reliable immunization tracking system to keep children on schedule and avoid unnecessary immunizations. In most states, however, only health care providers who are enrolled in the VFC Program are required to enter data into the IIS. Should all providers be required to enter …

Osteopontin Facilitates West Nile Nirus Neuroinvasion Via Neutrophil "Trojan Horse" Transport, Amber M. Paul, Dhiraj Acharya, Laurel Duty, E. Ashley Thompson, Linda Le, Dobrivoje S. Stokic, A. Arturo Leis, Fengwei Bai

Faculty Publications

West Nile virus (WNV) can cause severe human neurological diseases including encephalitis and meningitis. The mechanisms by which WNV enters the central nervous system (CNS) and host-factors that are involved in WNV neuroinvasion are not completely understood. The proinflammatory chemokine osteopontin (OPN) is induced in multiple neuroinflammatory diseases and is responsible for leukocyte recruitment to sites of its expression. In this study, we found that WNV infection induced OPN expression in both human and mouse cells. Interestingly, WNV-infected OPN deficient (Opn −/−) mice exhibited a higher survival rate (70%) than wild type (WT) control mice (30%), suggesting OPN plays a …

Normal Behavioral Responses To Light And Darkness And The Pupillary Light Reflex Are Dependent Upon The Olivary Pretectal Nucleus In The Diurnal Nile Grass Rat, Andrew J. Gall, Ohanes S. Khacherian, Brandi Ledbetter, Sean P. Deats, Megan Luck, Laura Smale, Lily Yan, Antonio A. Nunez

Faculty Publications

The olivary pretectal nucleus (OPT) is a midbrain structure that receives reciprocal bilateral retinal projections, is involved in the pupillary light reflex, and connects reciprocally with the intergeniculate leaflet (IGL), a retinorecipient brain region that mediates behavioral responses to light pulses (i.e., masking) in diurnal Nile grass rats. Here, we lesioned the OPT and evaluated behavioral responses in grass rats to various lighting conditions, as well as their anxiety-like responses to light exposure. While control grass rats remained diurnal, grass rats with OPT lesions exhibited a more night-active pattern under 12h:12h light-dark (LD) conditions. However, when placed in constant darkness, …

Cpx-Dependent Expression Of Yqja Requires Cations At Elevated Ph, Sujeet Kumar, Vijay Tiwari, William T. Doerrler

Faculty Publications

© FEMS 2017. All rights reserved. Under alkaline pH conditions, Escherichia coli must maintain a stable cytoplasmic pH of about 7.6 that is acidic relative to the environment. Bacteria employ various mechanisms to survive alkaline pH; however, membrane cation/H+ antiporters play a primary role by facilitating inward transport of protons. Escherichia coli YqjA belongs to the DedA/Tvp38 membrane protein family and, along with its paralog YghB, is required for growth at 42°C, proper cell division and antibiotic resistance. YqjA is required for viability at alkaline pH, requiring cations sodium or potassium to support growth under these conditions, suggesting it may …

Breastfeeding Practices, Beliefs, And Social Norms In Low-Resource Communities In Mexico: Insights For How To Improve Future Promotion Strategies, Tessa M. Swigart, Anabelle Bonvecchio, Florence L. The´Odore, Sophia Zamudio-Hass, Maria Angeles Villanueva-Borbolla, Jim Thrasher

Faculty Publications

INTRODUCTION:

Breastfeeding is recommended exclusively for the first 6 months after birth, with continued breastfeeding for at least 2 years. Yet prevalence of these recommendations is low globally, although it is an effective and cost-effective way to prevent serious infections and chronic illness. Previous studies have reported that social support greatly influences breastfeeding, but there is little evidence on perceived social norms in Mexico and how they affect actual behavior.

OBJECTIVE:

Our objective was to investigate breastfeeding intention, practices, attitudes, and beliefs, particularly normative, among low-resource communities in central and southern Mexico.

METHODS:

We performed a secondary analysis using the …

Congress And Commercial Trusts: Dealing With Diversity Jurisdiction Post-Americold, S. I. Strong

Faculty Publications

The treatment of commercial trusts reached its nadir in early 2016, when the U.S. Supreme Court held in Americold Realty Trust v. ConAgra Foods, Inc. that the citizenship of a commercial trust should be equated with that of its shareholder-beneficiaries for purposes of diversity jurisdiction. Unfortunately, the sheer number of shareholder-beneficiaries in most commercial trusts (often amounting to hundreds if not thousands of individuals) typically precludes the parties' ability to establish complete diversity and thus eliminates the possibility of federal jurisdiction over most commercial trust disputes. As a result, virtually all commercial trust disputes will now be heard in state …

Assessing The Viability Of Race-Neutral Alternatives In Law School Admissions, Eboni S. Nelson

Faculty Publications

No abstract provided.

Effect Of Rickettsia Felis Strain Variation On Infection, Transmission, And Fitness In The Cat Flea (Siphonaptera: Pulicidae), Sean P. Healy, Lisa D. Brown, Melena R. Hagstrom, Lane D. Foil, Kevin R. Macaluso

Faculty Publications

© The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. Rickettsia felis is a human pathogen transmitted by the cat flea, Ctenocephalides felis (Bouché) (str. LSU), as well as an obligate symbiont of the parthenogenic booklouse Liposcelis bostrychophila (Badonnel) (str. LSU-Lb). The influence of genetic variability in these two strains of R. felis on host specialization and fitness and possible resulting differences on infection and transmission kinetics in C. felis is unknown. Utilizing an artificial host system, cat fleas were exposed to a R. felis str. LSU-Lb-infected bloodmeal and monitored for infection at 7-d …

Federalism Implications Of Non-Recognition Of Licensure Reciprocity Under The Gun-Free School Zones Act, Royce De R. Barondes

Faculty Publications

The Gun-Free School Zones Act (GFSZA) criminalizes firearms possession within 1000 feet of an elementary or secondary school in a State unless the possessor "is licensed to do so by the State in which the school zone is located" (or one of a few other exceptions applies). The Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) has in correspondence opined licensure through reciprocity does not make one so licensed by the State.

School zones covered by the act are ubiquitous. Were the ATF's interpretation adopted, large swaths of many States' non-rural areas would be prohibited zones for non-residents who carry …

Zika And The Regulatory Regime For Licensing Vaccines For Use During Pregnancy, Sam F. Halabi

Faculty Publications

Microcephaly and other severe fetal brain defects (congenital Zika syndrome) caused by the Zika virus have prompted an urgent effort to develop and license a safe and efficacious vaccine. Yet, that effort has run up against one of the most formidable barriers in vaccine research: pregnant women are almost always excluded from clinical trials for fear that the intervention may harm the fetus. This article analyzes the existing regulatory framework for vaccines intended for use during pregnancy in an effort to identify ways the process may be reconsidered in light of recent public health emergencies that had a disproportionate effect …

The Pesky Serial Comma, Douglas E. Abrams

Faculty Publications

No abstract provided.

Impact Of Multileaf Collimator Configuration Parameters On The Dosimetric Accuracy Of 6-Mv Intensity-Modulated Radiation Therapy Treatment Plans, Nick Petersen, David Perrin, Wayne Newhauser, Rui Zhang

Faculty Publications

The purpose of this study was to evaluate the impact of selected configuration parameters that govern multileaf collimator (MLC) transmission and rounded leaf offset in a commercial treatment planning system (TPS) (Pinnacle3, Philips Medical Systems, Andover, MA, USA) on the accuracy of intensity-modulated radiation therapy (IMRT) dose calculation. The MLC leaf transmission factor was modified based on measurements made with ionization chambers. The table of parameters containing rounded-leaf-end offset values was modified by measuring the radiation field edge as a function of leaf bank position with an ionization chamber in a scanning water-tank dosimetry system and comparing the locations to …

A Descriptive And Broadly Applicable Model Of Therapeutic And Stray Absorbed Dose From 6 To 25 Mv Photon Beams:, Christopher W. Schneider, Wayne D. Newhauser, Lydia J. Wilson, Uwe Schneider, Robert Kaderka, Saveta Miljanic, Željka Kneževic, Liliana Stolarcyzk, Marco Durante, Roger M. Harrison

Faculty Publications

Purpose: To develop a simple model of therapeutic and stray absorbed dose for a variety of treatment machines and techniques without relying on proprietary machine-specific parameters. Methods: Dosimetry measurements conducted in this study and from the literature were used to develop an analytical model of absorbed dose from a variety of treatment machines and techniques in the 6 to 25 MV interval. A modified one-dimensional gamma-index analysis was performed to evaluate dosimetric accuracy of the model on an independent dataset consisting of measured dose profiles from seven treatment units spanning four manufacturers. Results: The average difference between the calculated and …

Il-4rα On Dendritic Cells In Neonates And Th2 Immunopathology In Respiratory Syncytial Virus Infection, Bishwas Shrestha, Dahui You, Jordy Saravia, David T. Siefker, Sridhar Jaligama, Greg I. Lee, Asmaa A. Sallam, Jeffrey N. Harding, Stephania A. Cormier

Faculty Publications

© Society for Leukocyte Biology. Respiratory syncytial virus (RSV) is one of the leading causes of bronchiolitis in children, and severe RSV infection early in life has been associated with asthma development. Using a neonatal mouse model, we have shown that down-regulation of IL-4 receptor α (IL-4Rα) with antisense oligonucleotides in the lung during neonatal infection protected from RSV immunopathophysiology. Significant down-regulation of IL-4Rα was observed on pulmonary CD11b+ myeloid dendritic cells (mDCs) suggesting a role for IL-4Rα on mDCs in the immunopathogenesis of neonatal RSV infection. Here, we demonstrated that neonatal CD11b+ mDCs expressed higher levels of IL-4Rα than …

Inversion Of The Imprinting Control Region Of The Peg3 Domain, Joomyeong Kim, Hongzhi He, Hana Kim

Faculty Publications

© 2017 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The imprinting of the mouse Peg3 domain is controlled through a 4-kb genomic region encompassing the bidirectional promoter and 1st exons of Peg3 and Usp29. In the current study, this ICR was inverted to test its orientation dependency for the transcriptional and imprinting control of the Peg3 domain. The inversion resulted in the exchange of promoters and 1st exons between Peg3 …