Digital Commons Network^™

Factors Associated With Quit Attempts And Smoking Cessation In Brazil: Findings From The International Tobacco Control Brazil Survey, Leticia Casado, Jim Thrasher, Cristina Perez, Luiz Claudio Thuler, Geoffrey T. Fong

Faculty Publications

Background:
In Brazil, the treatment of tobacco dependence is available at no cost. This study aimed to identify factors associated with attempting to quit and of successful smoking cessation in a population-based sample of Brazilian smokers.

Methods:
Data came from the first two waves of the International Tobacco Control (ITC) Brazil Survey, conducted in 2009 and 2012/2013 in three cities: Rio de Janeiro, São Paulo, and Porto Alegre. Prospective cohort data were collected from 488 adults (≥18 years) who smoked at Wave 1 who were resurveyed at Wave 2. Crude and adjusted relative risks (RR) for two outcomes (making a …

Integrating Nutrition Into Health Systems At Community Level:Impact Evaluation Of The Community‐Based Maternal Andneonatal Health And Nutrition Projects In Ethiopia, Kenya, And Senegal, Jacqueline K. Kung'u, Richard Pendame, Mame Bineta Ndiaye, Mulusew Gerbaba, Sophie Ochola, Adama Faye, Sulochana Basnet, Edward A. Frongillo Jr., Sara Wuehler, Luz Maria De‐Regil

Faculty Publications

Maternal undernutrition and mortality remain high in several African countries. Key nutrition andhealth interventions improve maternal and birth outcomes. Evidence is scarce on how tostrengthen health systems to ensure pregnant women and newborns are reached with theseinterventions. We conducted three quasi‐experimental nonrandomized Community BasedMaternal and Neonatal Health and Nutrition projects in regions of Ethiopia, Senegal, and Kenyato demonstrate how proven nutrition interventions could be integrated into health programs toimprove knowledge and practices during pregnancy, birth, and postpartum. We evaluated impacton knowledge and practices related to maternal and neonatal care using logistic regression andrepeated‐measures models with districts as a fixed variable …

Privacy As Commons: Case Evaluation Through The Governing Knowledge Commons Framework, Brett Frischmann, Madelyn Sanfilippo, Katherine Strandburg

Faculty Publications

Conceptualizing privacy as information flow rules-in-use constructed within a commons governance arrangement, we adapt the Governing Knowledge Commons (GKC) framework to study the formal and informal governance of information flows. We incorporate Helen Nissenbaum's “privacy as contextual integrity” approach, defining privacy in terms of contextually appropriate flows of personal information. While Nissenbaum's framework treats contextual norms as largely exogenous and emphasizes their normative valence, the GKC framework provides a systematic method to excavate personal information rules-in-use that actually apply in specific situations and interrogate governance mechanisms that shape rules-in-use. The GKC framework thus directs attention beyond information transmission principles to …

Supporting Strong Families And Capable Communities Through Cross-National Research, Nathan C. Taylor, Deborah K. Hartman, Richard J. Bischoff, Alan Hayes, Paul R. Springer, Hazel E. Dalton, David Perkins

Faculty Publications

Mental and behavioral ill-health are growing global problems and while there are promising evidence-based approaches aimed at reducing their impact, availability of services varies greatly, not only across nations, but also between urban, regional, and remote locations. Rural areas face accessibility and acceptability challenges related to mental health services that are similar to barriers experienced in developing countries. Initiatives to address mental health challenges in under-served rural areas can inform global mental health strategies.

Institutionalizing Resilience In U.S. Universities: Prospects, Opportunities, And Models, Morris Foster, James O'Donnell, Mark Luckenbach, Elizabeth Andrews, Emily Steinhilber, John Wells, Mark Davis

Faculty Publications

No abstract provided.

Identifying Apparent Local Stable Isotope Equilibrium In A Complex Non-Equilibrium System, Yuyang He, Xiaobin Cao, Jianwei Wang, Huiming Bao

Faculty Publications

Copyright © 2017 John Wiley & Sons, Ltd. Rationale: Although being out of equilibrium, biomolecules in organisms have the potential to approach isotope equilibrium locally because enzymatic reactions are intrinsically reversible. A rigorous approach that can describe isotope distribution among biomolecules and their apparent deviation from equilibrium state is lacking, however. Methods: Applying the concept of distance matrix in graph theory, we propose that apparent local isotope equilibrium among a subset of biomolecules can be assessed using an apparent fractionation difference (|Δα|) matrix, in which the differences between the observed isotope composition (δ') and the calculated equilibrium fractionation factor (1000lnβ) …

Identifying Apparent Local Stable Isotope Equilibrium In A Complex Non-Equilibrium System, Yuyang He, Xiaobin Cao, Jianwei Wang, Huiming Bao

Faculty Publications

Copyright © 2017 John Wiley & Sons, Ltd. Rationale: Although being out of equilibrium, biomolecules in organisms have the potential to approach isotope equilibrium locally because enzymatic reactions are intrinsically reversible. A rigorous approach that can describe isotope distribution among biomolecules and their apparent deviation from equilibrium state is lacking, however. Methods: Applying the concept of distance matrix in graph theory, we propose that apparent local isotope equilibrium among a subset of biomolecules can be assessed using an apparent fractionation difference (|Δα|) matrix, in which the differences between the observed isotope composition (δ') and the calculated equilibrium fractionation factor (1000lnβ) …

Physico-Chemical Characteristics Of Evaporating Respiratory Fluid Droplets, Eric P. Vejerano, Linsey C. Marr

Faculty Publications

The detailed physico-chemical characteristics of respiratory droplets in ambient air, where they are subject to evaporation, are poorly understood. Changes in the concentration and phase of major components in a droplet—salt (NaCl), protein (mucin) and surfactant (dipalmitoylphosphatidylcholine)—may affect the viability of any pathogens contained within it and thus may affect the efficiency of transmission of infectious disease by droplets and aerosols. The objective of this study is to investigate the effect of relative humidity (RH) on the physico-chemical characteristics of evaporating droplets of model respiratory fluids. We labelled these components in model respiratory fluids and observed evaporating droplets suspended on …

Diverse Exocytic Pathways For Mast Cell Mediators, Hao Xu, Na-Ryum Bin, Shuzo Sugita

Faculty Publications

Mast cells play pivotal roles in innate and adaptive immunities but are also culprits in allergy, autoimmunity and cardiovascular diseases. Mast cells respond environmental changes by initiating regulated exocytosis/secretion of various biologically active compounds called mediators (e.g., proteases, amines and cytokines). Many of these mediators are stored in granules/lysosomes and rely on an intricate degranulation process for release. Mast cell stabilizers (such as sodium cromoglicate) which prevent such degranulation process have therefore been clinically approved to treat asthma and allergic rhinitis. However, it has become increasingly clear that different mast cell diseases often involve multiple mediators, which seem to rely …

Dimensions Of Short-Term And Long-Term Self-Regulation In Adolescence: Associations With Maternal And Paternal Parenting And Parent-Child Relationship Quality, Kristin L. Moilanen, Laura M. Padilla-Walker, Debra R. Blaacker

Faculty Publications

Relatively little is known about the degree to which subcomponents of self-regulation change during early to middle adolescence. This study considered familial predictors (maternal/paternal regulatory support, antagonistic parenting, and parent-child closeness) of rank-order change in behavioral, emotional and cognitive regulation and perseverance over one year. N = 452 adolescents ages 11–16 years and their parents completed questionnaires and parent-child discussion tasks (48.7% male; 69.6% white). Results indicated minimal direct effects of parenting, though maternal and paternal parenting and parent-child closeness exerted small effects that were moderated by prior levels of cognitive regulation and perseverance. Parents may contribute to the development …

Sociocultural And Health System Factors Associated With Mortality Among Febrile Inpatients In Tanzania: A Prospective Social Biopsy Cohort Study, Michael E. Snavely, Michael J. Maze, Charles Muiruri, Lilian Ngowi, Flora Mboya, Julia Beamesderfer, Glory F. Makupa, Anthon G. Mwingwa, Bingileki F. Lwezaula, Blandina T. Mmbaga, Venance P. Maro, John A. Crump, Jan Ostermann, Matthew P. Rubach

Faculty Publications

Introduction Communicable diseases are the leading causes of death in Tanzania despite the existence of effective treatment tools. We aimed to assess the sociocultural and health system factors associated with mortality from febrile illness in northern Tanzania.

Methods We interviewed febrile inpatients to determine prevalence of barriers in seeking or receiving care and grouped these barriers using the Three Delays model (delays at home, in transport and at healthcare facilities). We assessed 6-week mortality and, after matching on age, gender and severity of illness, measured the association between delays and mortality using conditional logistic regression.

Results We enrolled 475 children, …

Effects Of Cardiorespiratory Fitness And Weight Status On Knowledge Of Physical Activity And Fitness, Attitude Toward Physical Education, And Physical Activity, Senlin Chen, Xiangli Gu

Faculty Publications

Background: The purpose of this study was to examine the effects of cardiorespiratory fitness and weight status on knowledge of physical activity and fitness (PAF knowledge), attitude toward physical education (PE), and physical activity. Methods: A total of 343 middle school students participated in the study (Age: M/SD = 12.76/.94, ranging from 11 to 14 years old). PE Metrics™ was used to measure PAF knowledge, and Attitude toward Physical Education Questionnaire and Youth Activity Profile were used to measure attitude, physical activity and sedentary behavior. Fitness and weight status were assessed using FitnessGram and converted to in Healthy Fitness Zone …

Heart Rate-Defined Sustained Attention In Infants At Risk For Autism, Bridgette L. Tonnsen, J. E. Richards, Jane E. Roberts

Faculty Publications

Background: Although aberrant visual attention has been identified in infants at high familial risk for autism, the developmental emergence of atypical attention remains unclear. Integrating biological measures of attention into prospective high-risk infant studies may inform more nuanced developmental trajectories, clarifying the onset and course of atypical attention and potentially advancing early screening or treatment protocols. Heart rate-defined sustained attention (HRDSA) is a well-validated biological measure of attentional engagement that, in non-clinical infant populations, provides incremental information about attentional engagement beyond looking behaviors alone. The present study aimed to examine the characteristics and clinical correlates of HRDSA in high-risk infants, …

Hypertension, Genes, And Environment: Challenges For Prevention And Risk Prediction, Richard Cooper

Faculty Publications

No abstract provided.

A Novel Mir-375-Hoxb3-Cdca3/Dnmt3b Regulatory Circuitry Contributes To Leukemogenesis In Acute Myeloid Leukemia, Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen, Shenmeng Gao

Faculty Publications

Background: Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies due to sophisticated genetic mutations and epigenetic dysregulation. MicroRNAs (miRNAs), a class of small non-coding RNAs, are important regulators of gene expression in all biological processes, including leukemogenesis. Recently, miR-375 has been reported to be a suppressive miRNA in multiple types of cancers, but its underlying anti-leukemia activity in AML is largely unknown. Methods: Quantitative reverse transcriptase PCR (qRT-PCR) was used to measure the expression of miR-375 and HOXB3 in leukemic cells and normal controls. Targets of miR-375 were confirmed by western blot and luciferase assay. Phenotypic effects …

Recently Integrated Alu Insertions In The Squirrel Monkey (Saimiri) Lineage And Application For Population Analyses, Jasmine N. Baker, Jerilyn A. Walker, Michael W. Denham, Charles D. Loupe, Mark A. Batzer

Faculty Publications

© 2018 The Author(s). Background: The evolution of Alu elements has been ongoing in primate lineages and Alu insertion polymorphisms are widely used in phylogenetic and population genetics studies. Alu subfamilies in the squirrel monkey (Saimiri), a New World Monkey (NWM), were recently reported. Squirrel monkeys are commonly used in biomedical research and often require species identification. The purpose of this study was two-fold: 1) Perform locus-specific PCR analyses on recently integrated Alu insertions in Saimiri to determine their amplification dynamics, and 2) Identify a subset of Alu insertion polymorphisms with species informative allele frequency distributions between the Saimiri sciureus …

Dietary Inflammatory Index And Cardiovascular Risk And Mortality—A Meta-Analysis, Nitin Shivappa, Justyna Godos, James R. Hébert, Michael Wirth, Gabriele Piuri, Attilio Speciani, Giuseppe Grosso

Faculty Publications

Diet and chronic inflammation have been suggested to be risk factors in the development of cardiovascular disease (CVD) and related mortality. The possible link between the inflammatory potential of diet measured through the Dietary Inflammatory Index (DII^®) and CVD has been investigated in several populations across the world. The aim of this study was to conduct a meta-analysis on studies exploring this association. Data from 14 studies were eligible, of which two were case-control, eleven were cohort, and one was cross-sectional. Results from the random-effects meta-analysis showed a positive association between increasing DII, indicating a pro-inflammatory diet, and …

Parasite Component Community Of Smalltooth Sawfish Off Florida: Diversity, Conservation Concerns, And Research Applications, Micah D. Bakenhaster, Stephen A. Bullard, Stephen S. Curran, Delane C. Kritsky, Erin H. Leone, Lauren K. Partridge, Carlos F. Ruiz, Rachel M. Scharer, Gregg R. Poulakis

Faculty Publications

Compared with that of other charismatic elasmobranchs, the component community of metazoan parasites infecting endangered smalltooth sawfish Pristis pectinata is exceedingly poorly characterized: adults of Dermophthirioides pristidis and Neoheterocotyle inpristi (ectoparasitic flatworms of skin and gill, respectively) were the only confirmed parasites prior to the description, based on specimens reported herein, of Mycteronastes caalusi. Our opportune and directed parasitological examinations of 290 smalltooth sawfish (277 live inspections; 13 necropsies; 671 to 2640 mm stretch total length) in south Florida coastal waters revealed at least 8 species of Platyhelminthes, 9 of Arthropoda, 4 of Annelida, and 1 of Nematoda. This …

Increasing Research Capacity In Underserved Communities: Formative And Summative Evaluation And Summative Evaluation Of The Mississippi Community Research Fellows Training Program (Cohort 1), Danielle Fastring, Susan Mayfield-Johnson, Tanya Funchess, Candice Green, Victoria Walker, Georgette Powell

Faculty Publications

Background: The Mississippi Community Research Fellows Training Program (MSCRFTP) is a 15-week program conducted in Jackson, MS, USA consisting of training in the areas of evidence-based public health, research methods, research ethics, and cultural competency. The purpose of the program was to increase community knowledge and understanding of public health research, develop community-based projects that addressed health disparity in the participants’ community, increase individual and community capacity, and to engage community members as equal partners in the research process.

Methods: A comprehensive evaluation of the MSCRFTP was conducted that included both quantitative and qualitative methods. All participants were asked to …

Facilitators And Barriers For Hiv-Testing In Zambia: A Systematic Review Of Multi-Level Factors, Shan Qiao Ph.D., Yao Zhang, Xiaoming Li Ph.D., J. Anitha Menon

Faculty Publications

It was estimated that 1.2 million people live with HIV/AIDS in Zambia by 2015. Zambia has developed and implemented diverse programs to reduce the prevalence in the country. HIVtesting is a critical step in HIV treatment and prevention, especially among all the key populations. However, there is no systematic review so far to demonstrate the trend of HIV-testing studies in Zambia since 1990s or synthesis the key factors that associated with HIVtesting practices in the country. Therefore, this study conducted a systematic review to search all English literature published prior to November 2016 in six electronic databases and retrieved 32 …

Lower Dietary Inflammatory Index Scores Are Associated With Lower Glycemic Index Scores Among College Students, Yeonsoo Kim, Jie Chen, Michael Wirth, Nitin Shivappa, James R. Hébert

Faculty Publications

The association between the Dietary Inflammatory Index (DII^®), the glycemic index (GI), and the glycemic load (GL) is not known, although it is known that carbohydrates are pro-inflammatory. We aimed to measure the association between the DII and both GI and GL among college students. In this cross-sectional study, 110 college students completed a 3-day food diary, which was used to calculate the DII, the GI, the GL, and the healthy eating index (HEI)-2010. Least square means and 95% confidence intervals of the GI, the GL, and the HEI-2010 were presented per DII tertile using generalized linear mixed …

Testing Cessation Messages For Cigarette Package Inserts: Findings From A Best/Worst Discrete Choice Experiment, Jim Thrasher, Farahnaz Islam, Rachel E. Davis, Lucy Popova, Victoria Lambert, Yoo Jin Cho, Ramzi G. Salloum, Jordan Louviere, David Hammond

Faculty Publications

This study assessed smokers’ responses to different smoking cessation topics and imagery for cigarette package inserts. Adult smokers from Canada (n = 1000) participated in three discrete choice experiments (DCEs): DCE 1 assessed five cessation benefit topics and five imagery types; DCE 2 assessed five messages with tips to improve cessation success and five imagery types; DCE 3 assessed four reproductive health benefits of cessation topics and four imagery types. In each DCE, participants evaluated four or five sets of four inserts, selecting the most and least motivating (DCEs 1 & 3) or helpful (DCE 2) for quitting. Linear mixed …

Stepping It Up: Walking Behaviors In Children Transitioning From 5th To 7th Grade, Sharon E. Taverno Ross, Morgan N. Clennin, Marsha Dowda, Natalie Colabianchi, Russell R. Pate

Faculty Publications

The purpose of this study was to (1) describe children’s walking behaviors in 5th to 7th grade and change over time and (2) examine associations between walking behaviors and Walk Score®. Participants consisted of n = 586 students from the Transitions and Activity Changes in Kids (TRACK) Study. Children reported any walking behavior (e.g., exercise and transportation) over the past five days. Walk Score was calculated based on children’s home address. Descriptive statistics summarized walking behaviors by gender and time, and repeated measure mixed models examined the relationship between walking behaviors and Walk Score. Approximately 46.8% and 19.2% of 5th …

The Use Of Anecdotal Information In A Hypothetical Lung Cancer Treatment Decision, Preston Brown, Victor Kwan, Michael Vallerga, Hardeep Obhi, Erin Woodhead

Faculty Publications

This mixed-methods study examined variables associated with use of experience-based (i.e., anecdotal) decisional strategies among 85 undergraduate students presented with 2 hypothetical lung cancer scenarios. Participants were asked to think aloud while they made their treatment choice. Eleven decisional strategies were identified and grouped into either data or experience-based strategies. Approximately, 25% of participants used experience-based strategies. Use of experience-based strategies was more likely if the participant reported involvement in the life of someone going through cancer treatment, and if they rated print-based media sources as less important. Use of experience-based strategies was associated with choosing surgery instead of radiation …

Aromatic Interactions At The Ligand–Protein Interface: Implications For The Development Of Docking Scoring Functions, Michal Brylinski

Faculty Publications

© 2017 John Wiley & Sons A/S The ability to design and fine-tune non-covalent interactions between organic ligands and proteins is indispensable to rational drug development. Aromatic stacking has long been recognized as one of the key constituents of ligand–protein interfaces. In this communication, we employ a two-parameter geometric model to conduct a large-scale statistical analysis of aromatic contacts in the experimental and computer-generated structures of ligand–protein complexes, considering various combinations of aromatic amino acid residues and ligand rings. The geometry of interfacial π–π stacking in crystal structures accords with experimental and theoretical data collected for simple systems, such as …

Recently Integrated Alu Insertions In The Squirrel Monkey (Saimiri) Lineage And Application For Population Analyses, Mark Batzer, Jasmine N. Baker, Jerilyn A. Walker, Michael W. Denham, Charles D. Loupe

Faculty Publications

Background: The evolution of Alu elements has been ongoing in primate lineages and Alu insertion polymorphisms are widely used in phylogenetic and population genetics studies. Alu subfamilies in the squirrel monkey (Saimiri), a New World Monkey (NWM), were recently reported. Squirrel monkeys are commonly used in biomedical research and often require species identification. The purpose of this study was two-fold: 1) Perform locus-specific PCR analyses on recently integrated Alu insertions in Saimiri to determine their amplification dynamics, and 2) Identify a subset of Alu insertion polymorphisms with species informative allele frequency distributions between the Saimiri sciureus and Saimiri boliviensis groups. …

A Strategy For Sperm Cryopreservation Of Atlantic Salmon, Salmo Salar, For Remote Commercial-Scale High-Throughput Processing, Huiping Yang, E. Hu, John T. Buchanan, Terrence R. Tiersch

Faculty Publications

Sperm cryopreservation is an essential tool for long-term storage of genetic resources for aquaculture fishes. The goal of this study was to develop an efficient and streamlined protocol for high-throughput processing for sperm cryopreservation in Atlantic salmon, Salmo salar. The objectives were to evaluate: (1) osmolality of blood serum for determining extender osmolality, (2) effects of extenders for fresh sperm dilution and refrigerated storage, (3) effects of methanol and dimethyl sulfoxide (DMSO) on fresh sperm motility, and (4) motility and fertility after thawing. In this study, sperm samples were collected at a hatchery site in Canada and shipped to a …

A Three Year Study Of Metal Levels In Skin Biopsies Of Whales In The Gulf Of Mexico After The Deepwater Horizon Oil Crisis, John Pierce Wise, James T.F. Wise, Catherine F. Wise, Sandra S. Wise, Christy Gianios, Hong Xie, Ron Walter, Mikki Boswell, Cairong Zhu, Tongzhang Zheng, Christopher Perkins, John Pierce Wise

Faculty Publications

In response to the explosion of the Deepwater Horizon and the massive release of oil that followed, we conducted three annual research voyages to investigate how the oil spill would impact the marine offshore environment. Most investigations into the ecological and toxicological impacts of the Deepwater Horizon Oil crisis have mainly focused on the fate of the oil and dispersants, but few have considered the release of metals into the environment. From studies of previous oil spills, other marine oil industries, and analyses of oil compositions, it is evident that metals are frequently encountered. Several metals have been reported in …

In Vitro Digestible Properties And Quality Characterization Of Nonsucrose Gluten-Free Lentinus Edodes Cookies, Tao Feng, Wenxin Wang, Haining Zhuang, Shiqing Song, Lingyun Yao, Min Sun, Zhimin Xu

Faculty Publications

Lentinus edodes was included in nonsucrose gluten-free cookie formulations. Their digestible properties and quality features were analyzed. Six various types of cookies were prepared through the use of 0, 5, 10, 15, 20, and 25% of Lentinus edodes powder. The quality features of cookies and cookie dough, as well as digestibility were measured. To which level consumers were attracted by the six types of cookie was assessed. The quality features of the six types of cookies varied significantly to different degrees. Nevertheless, these differences failed to change the acceptance of consumers for nonsucrose gluten-free Lentinus edodes cookies. The digestibility properties …

Role Of Resistant Starch On Diabetes Risk Factors In People With Prediabetes: Design, Conduct, And Baseline Results Of The Starch Trial, Kara L. Marlatt, Ursula A. White, Robbie A. Beyl, Courtney M. Peterson, Corby K. Martin, Maria L. Marco, Michael J. Keenan, Roy J. Martin, Kayanush J. Aryana, Eric Ravussin

Faculty Publications

Dietary resistant starch (RS) might alter gastrointestinal tract function in a manner that improves human health, particularly among adults at risk for diabetes. Here, we report the design and baseline results (with emphasis on race differences) from the STARCH trial, the first comprehensive metabolic phenotyping of people with prediabetes enrolled in a randomized clinical trial testing the effect of RS on risk factors for diabetes. Overweight/obese participants (BMI ≥ 27 kg/m2 and weight ≤ 143 kg), age 35–75 y, with confirmed prediabetes were eligible. Participants were randomized to consume 45 g/day of RS (RS = amylose) or amylopectin (Control) for …