Digital Commons Network^™

Associations Between Polycyclic Aromatic Hydrocarbon-Related Exposures And P53 Mutations In Breast Tumors, Irina Mordukhovich, Pavel Rossner Jr., Mary Beth Terry, Regina M. Santella, Yu-Jing Zhang, Hanina Hibshoosh, Lorenzo Memeo, Mahesh Mansukhani, Chang-Min Long, Gail Garbowski, Meenakshi Agrawal, Mia M. Gaudet, Susan E. Steck, Sharon K. Sagiv, Sybil M. Eng, Susan L. Teitelbaum, Alfred I. Neugut, Kathleen Conway-Dorsey, Marilie D. Gammon

Faculty Publications

BACKGROUND: Previous studies have suggested that polycyclic aromatic hydrocarbons (PAHs) may be associated with breast cancer. However, the carcinogenicity of PAHs on the human breast remains unclear. Certain carcinogens may be associated with specific mutation patterns in the p53 tumor suppressor gene, thereby contributing information about disease etiology.

OBJECTIVES: We hypothesized that associations of PAH-related exposures with breast cancer would differ according to tumor p53 mutation status, effect, type, and number.

METHODS: We examined this possibility in a population-based case–control study using polytomous logistic regression. As previously reported, 151 p53 mutations among 859 tumors were identified using Surveyor nuclease and …

Evolutionary Enforcement At The Securities And Exchange Commission, Jayne W. Barnard

Faculty Publications

Hundreds of critics in the past eighteen months have heaped abuse on the SEC Enforcement Division. How could the Division have missed so much misbehavior on Wall Street? How could the Division's young lawyers have been charmed by Bernie Madoff and thwarted from discovering his terrible crimes? Most critics seem to agree that the Division's most urgent needs include developing substantially more financial sophistication among Division lawyers and investigators; better communications within the Commission and with other federal agencies; and a meaningful system for handling tips and processing information. The SEC's response to its critics has been remarkable. The Commission …

Giving Birth: The Voices Of Ecuadorian Women, Lynn Clark Callister, Cheryl A. Corbett, Shelly Reed, Cassidy Tomao, Katie G. Thornton

Faculty Publications

Purpose: The purpose of this ethnographic study was to describe the perceptions of Ecuadorian childbearing women. Background: No studies published in English could be found documenting the perspectives of Ecuadorian childbearing women about their birth experiences. Method: Thirty-two women who had recently given birth in Guayaquil, Ecuador participated in audiotaped interviews, which were analyzed as appropriate for ethnographic inquiry. Results: “Enduring birth to obtain the gift” was the overarching theme. Supporting themes included caring for self and accessing prenatal care to have a healthy newborn; relying on God to ensure positive maternal/newborn outcomes; submission of self to healthcare providers because …

Parental Entitlement And Corporal Punishment, James G. Dwyer

Faculty Publications

No abstract provided.

Synergistic Solutions: An Integrated Approach To Solving The Caregiver Conundrum For "Real" Workers, Nicole Buonocore Porter

Faculty Publications

This Article is the second part of a project aimed at ending caregiver discrimination for all workers who are struggling to balance work and family. The first part of the project argued that the communitarian theory supports the broad reform envisioned, and this piece articulates that vision. This reform project utilizes a synergy of solutions, taking a comprehensive and creative approach to ending the caregiver conundrum for all working caregivers. The proposal includes the use of various statutory provisions that work together to avoid some of the deficiencies created by other proposals. Specifically, the proposal attempts to address the three …

Pizza-Box Contracts: True Tales Of Consumer Contracting Culture, Amy J. Schmitz

Faculty Publications

Do you ask for contract or purchase terms prior to completing your everyday purchases? Do you first read the pizza box before paying the pizza delivery guy or gal? Typical consumers do not ask for or read their contracts prepurchase, and companies have become accustomed to burying purchase terms in product packaging or Internet links. These postpurchase, rolling, or “pizza-box” contracts have therefore become the norm in the consumer marketplace, and courts generally enforce them as legitimate contracts. This Article discusses varying theoretical perspectives on enforcement of these pizza-box contracts, and explores the available empirical data bearing on the legitimacy …

Is The Sabbath Part Of The "New Covenant"?, Roy E. Gane

Faculty Publications

No abstract provided.

Pastors’ Perspectives On Assimilating New Members: Part 2–Discipling Strategies, Jane Thayer

Faculty Publications

No abstract provided.

Who Guidelines For Antimicrobial Treatment In Children Admitted To Hospital In An Area Of Intense Plasmodium Falciparum Transmission: Prospective Study, Behzad Nadjm, Ben Amos, George Mtove, Jan Ostermann, Semkini Chonya, Hannah Wangai, Juma Kimera, Walii Msuya, Frank Mtei, Denise Dekker, Rajabu Malahiyo, Raimos Olomi, John A. Crump, Christopher J. M. Whitty, Hugh Reyburn

Faculty Publications

Objectives To assess the performance of WHO’s “Guidelines for care at the first-referral level in developing countries” in an area of intense malaria transmission and identify bacterial infections in children with and without malaria.

Design Prospective study.

Setting District hospital in Muheza, northeast Tanzania.

Participants Children aged 2 months to 13 years admitted to hospital for febrile illness.

Main outcome measures Sensitivity and specificity of WHO guidelines in diagnosing invasive bacterial disease; susceptibility of isolated organisms to recommended antimicrobials.

Results Over one year, 3639 children were enrolled and 184 (5.1%) died; 2195 (60.3%) were blood slide positive for Plasmodium falciparum …

Virus-Triggered Ubiquitination Of Traf3/6 By Ciap1/2 Is Essential For Induction Of Interferon- &Beta (Ifn-&Beta) And Cellular Antiviral Response, Ai-Ping Mao, Shu Li, Bo Zhong, Ying Li, Jie Yan, Qi Li, Chengwen Teng Pharm.D.. Ph.D, Hong-Bing Shu

Faculty Publications

Viral infection causes activation of transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs) and cellular antiviral response. Here we show that knockdown of the E3 ubiquitin ligases cIAP1 and cIAP2 markedly inhibited virus-triggered activation of IRF3 and NF-κB as well as IFN-β induction. Knockdown of cIAP1 and cIAP2 also inhibited cytoplasmic dsRNA-triggered cellular antiviral response. Endogenous coimmunoprecipitation experiments indicated that viral infection caused recruitment of cIAP1 and cIAP2 to TRAF3, TRAF6, and VISA. Furthermore, we demonstrated that cIAP1- and cIAP2-mediated virus-triggered ubiquitination of TRAF3 and TRAF6. These findings suggest that virus-triggered ubiquitination of TRAF3 and …

Climate Change, Environmental Justice, And Vulnerability: An Exploratory Spatial Analysis, Sacoby M. Wilson, Roland Richard, Lesley Joseph, Edith M. Williams

Faculty Publications

Research has demonstrated that vulnerable populations including disadvantaged populations of color live in areas that may place them at higher risk of exposure to social and environmental hazards. Due to climate change, these populations may experience worse health outcomes and environmental health disparities. The purpose of this project was to explore the use of Geographic Information Systems (GIS) to assess areas that may be vulnerable to climate change across the United States. We employed ArcGIS 9.3 to create vulnerability scores for areas across the country that may be that may be impacted by climate change at the county level in …

Potential For Misidentification Of Environmentally Persistent Free Radicals As Molecular Pollutants In Particulate Matter, Hieu Truong, Slawo Lomnicki, Barry Dellinger

Faculty Publications

Environmentally persistent free radicals (EPFRs) have been shown to form on the surfaces of various types of transition metal-containing particulate matter (PM), and it has been demonstrated they are capable of initiating adverse health impacts. Following sonification and solvent extraction for chemical analysis, they are partially converted to molecular species. Alcoholic solvents extracted the EPFRs with near 100% efficiency, while nonpolar hydrocarbon solvents exhibited < 20% efficiency and dichloromethane exhibited 20-55% efficiency. The extracted radicals reacted in solution to form multiple molecular reaction products including catechol, hydroquinone, phenol, chlorinated phenols, dibenzo-p-dioxin, and dibenzofuran. This suggests that EPFRs in environmental samples are indistinguishable from molecular pollutants and are subject to misidentification as molecular adsorbates when traditional extraction and chemical analysis methods are employed. On the basis of these findings, the origin of the toxicity of particulate matter contaminated with toxic organic compounds should be considered for re-evaluation to include the possibility that EPFRs may be a significant contributor, and the impact of some molecular pollutants may have been overestimated. © 2010 American Chemical Society.

Impaired Antiviral Activity Of Interferon Alpha Against Hepatitis C Virus 2a In Huh-7 Cells With A Defective Jak-Stat Pathway, Sidhartha Hazari, Partha K. Chandra, Bret Poat, Sibnarayan Datta, Robert F. Garry, Timothy P. Foster, Gus Kousoulas, Takaji Wakita, Srikanta Dash

Faculty Publications

Background. The sustained virological response to interferon-alpha (IFN-) in individuals infected with hepatitis C virus (HCV) genotype 1 is only 50%, but is about 80% in patients infected with genotype 2-6 viruses. The molecular mechanisms explaining the differences in IFN- responsiveness between HCV 1 and other genotypes have not been elucidated. Results. Virus and host cellular factors contributing to IFN responsiveness were analyzed using a green fluorescence protein (GFP) based replication system of HCV 2a and Huh-7 cell clones that either possesses or lack a functional Jak-Stat pathway. The GFP gene was inserted into the C-terminal non-structural protein 5A of …

Minimizing The Source Of Nociception And Its Concurrent Effect On Sensory Hypersensitivity: An Exploratory Study In Chronic Whiplash Patients, Geoff M. Schneider, Ashley D. Smith, Allen Hooper, Paul Stratford, Kathryn J. Schneider, Michael D. Westaway, Bevan Frizzell, Lee Olson

Faculty Publications

Abstract. Background. The cervical zygapophyseal joints may be a primary source of pain in up to 60% of individuals with chronic whiplash associated disorders (WAD) and may be a contributing factor for peripheral and centrally mediated pain (sensory hypersensitivity). Sensory hypersensitivity has been associated with a poor prognosis. The purpose of the study was to determine if there is a change in measures indicative of sensory hypersensitivity in patients with chronic WAD grade II following a medial branch block (MBB) procedure in the cervical spine. Methods. Measures of sensory hypersensitivity were taken via quantitative sensory testing (QST) consisting of pressure …

Early Childhood Feeding: Assessing Knowledge, Attitude, And Practices Of Multi-Ethnic Child-Care Providers, Marjorie Freedman, Karina Alvarez

Faculty Publications

Early childhood is a critical period for shaping and influencing feeding and lifestyle behaviors that have implications for future weight and health. With more women in the workforce, families have become reliant on child care. Thus, the child-feeding relationship has become a shared responsibility between the parent and child-care provider. Little is known about the impact of child-care providers on development of early childhood feeding behaviors and subsequent risk for obesity, especially in the Hispanic ethnic group. This research examined child-feeding attitudes, practices, and knowledge of multi-ethnic home-based and center-based child-care providers. Questionnaires were completed by a convenience sample of …

After Unitary Status: Examining Voluntary Integration Strategies For Southern School Districts, Danielle R. Holley-Walker

Faculty Publications

This Article provides empirical data on student assignment plans that are currently being used by Southern school districts that have recently attained unitary status. As the facts of Parents Involved in Community Schools demonstrate, Southern school districts will likely continue to be at the forefront of the struggle over voluntary integration efforts. Many Southern school districts are being released from desegregation orders that allowed the district to use race-conscious remedies to address previous de jure racial segregation. Without those court orders, the school district is faced with a choice about whether to continue to make racial integration a priority and …

Correlates Of Physical Activity In Black, Hispanic, And White Middle School Girls, Evelyn B. Kelly, Deborah Parra-Medina, Karin A. Pfeiffer, Marsha Dowda, Terry L. Conway, Larry S. Webber, Jared B. Jobe, Scott Going, Russell R. Pate

Faculty Publications

Background: A need exists to better understand multilevel influences on physical activity among diverse samples of girls. This study examined correlates of moderate-to-vigorous physical activity (MVPA) among adolescent girls from different racial/ethnic backgrounds. Methods: 1,180 6th grade girls (24.5% black, 15.7% Hispanic, and 59.8% white) completed a supervised self-administered questionnaire that measured hypothesized correlates of PA. MVPA data were collected for 6 days using the ActiGraph accelerometer. Hierarchical regression analysis was used to examine correlates of PA in each racial/ethnic group. Results: Hispanic girls (n=185) engaged in 21.7 minutes of MVPA per day, black girls (n=289) engaged in 19.5 minutes …

Gis And Injury Prevention And Control: History, Challenges, And Opportunities, Nathaniel Bell, Nadine Schuurman

Faculty Publications

Intentional and unintentional injury is the leading cause of death and potential years of life lost in the first four decades of life in industrialized countries around the world. Despite surgical innovations and improved access to emergency care, research has shown that certain populations remain particularly vulnerable to the risks and consequences of injury. Recent evidence has shown that the analytical, data linkage, and mapping tools of geographic information systems (GIS) technology provide can further address these determinants and identify populations in need. This paper traces the history of injury prevention and discusses current and future challenges in furthering our …

In Vitro And In Vivo Assessment Of Pulmonary Risk Associated With Exposure To Combustion Generated Fine Particles, Baher Fahmy, Liren Ding, Dahui You, Slawo Lomnicki, Barry Dellinger, Stephania A. Cormier

Faculty Publications

Strong correlations exist between exposure to PM2.5 and adverse pulmonary effects. PM2.5 consists of fine (≤2.5μm) and ultrafine (≤0.1μm) particles with ultrafine particles accounting for >70% of the total particles. Environmentally persistent free radicals (EPFRs) have recently been identified in airborne PM2.5. To determine the adverse pulmonary effects of EPFRs associated with exposure to elevated levels of PM2.5, we engineered 2.5μm surrogate EPFR-particle systems. We demonstrated that EPFRs generated greater oxidative stress in vitro, which was partly responsible for the enhanced cytotoxicity following exposure. In vivo studies using rats exposed to EPFRs containing particles demonstrated minimal adverse pulmonary effects. Additional …

Biological Control Of Tropical Soda Apple (Solanaceae) In Florida: Post-Release Evaluation, J. Medal, N. Bustamante, W. Overholt, R. Diaz, P. Stansly, A. Roda, D. Amalin, K. Hibbard, R. Gaskalla, B. Sellers, S. Hight, J. Cuda

Faculty Publications

The leaf feeding beetle Gratiana boliviana was released on tropical soda apple plants in Sumter County, FL., in 2006. The beetles significantly defoliated the plants over the period of the summers of 2006 and 2007, and became well established in the area.

Achiral And Chiral Separations Using Mekc, Polyelectrolyte Multilayer Coatings, And Mixed Mode Separation Techniques With Molecular Micelles, Candace A. Luces, Isiah M. Warner

Faculty Publications

Mixed mode (MM) separation using a combination of MEKC and polyelectrolyte multilayer (PEM) coatings is herein reported for the separation of achiral and chiral analytes. Many analytes are difficult to separate by MEKC and PEM coatings alone. Therefore, the implementation of a MM separation provides several advantages for overcoming the limitations of these well-established methods. In this study, it was observed that achiral separations using MEKC and PEM coatings individually resulted in partial resolution of eight very similar aryl ketones when the molecular micelle (sodium poly(N-undecanoyl-L-glycinate)) concentration was varied from 0.25 to 1.00% w/v and the bilayer number varied from …

Response To Calcium Channel Blocker Therapy In Black Hypertensive Patients, Thu T. Nguyen, Jay S. Kaufman, Richard S. Cooper

Faculty Publications

No abstract provided.

Rapid Assessment Of Genetic Ancestry In Populations Of Unknown Origin By Genome-Wide Genotyping Of Pooled Samples, Charleston W.K. Chiang, Zofia K.Z. Gajdos, Joshua M. Korn, Finny G. Kuruvilla, Johannah L. Butler, Rachel Hackett, Candace Guiducci, Thutrang T. Nguyen, Rainford Wilks, Terrence Forrester, Christopher A. Haiman, Katherine D. Henderson, Loic Le Marchand, Brian E. Henderson, Mark R. Palmert, Colin A. Mckenzie, Helen N. Lyon, Richard S. Cooper, Xiaofeng Zhu, Joel N. Hirschhorn

Faculty Publications

As we move forward from the current generation of genome-wide association (GWA) studies, additional cohorts of different ancestries will be studied to increase power, fine map association signals, and generalize association results to additional populations. Knowledge of genetic ancestry as well as population substructure will become increasingly important for GWA studies in populations of unknown ancestry. Here we propose genotyping pooled DNA samples using genome-wide SNP arrays as a viable option to efficiently and inexpensively estimate admixture proportion and identify ancestry informative markers (AIMs) in populations of unknown origin. We constructed DNA pools from African American, Native Hawaiian, Latina, and …

Accountability And Inaction: Ngos And Resource Lodging In Development, Matthew Harsh, Paul Mbatia, Wesley Shrum

Faculty Publications

From the late 1980s, research on NGOs had a normative focus and was vulnerable to changing donor preoccupations. This article contributes a new conceptual approach, analysing the practices through which relationships and resources are translated into programmes and projects. The theoretical justification for this move combines the new ethnography of development practice with a re-agency approach to transactions across time and space. The study is based on data including thirty hours of video ethnography involving interviews and field visits with Kenyan NGOs in a variety of sectors. The analysis focuses on the problem of accountability that emerged through the interactions …

Spontaneous Group Decision Making In Distributed Collaborative Learning: Toward A New Research Direction., Geoffrey Liu

Faculty Publications

This paper attempts to identify and establish spontaneous group decision making in collaborative learning as a new research direction, with particular attention to collaborative learning in distributed online environments. After a brief introduction, related concepts and theories are examined for differentiation of interpretation. The concept of “spontaneous group decision making” is established in the context of collaborative learning. Literature review is conducted to glean anecdotal observations from past research to identify potentially influential factors, and a diagram framework is proposed to charter the territory. The paper also reports findings from a preliminary survey of 159 graduate students on their group …

Neck Disorders Among Construction Workers: Understanding The Physical Loads On The Cervical Spine During Static Lifting Tasks, Ashish D. Nimbarte, Fereydoun Aghazadeh, Laura H. Ikuma, Craig M. Harvey

Faculty Publications

In this study a common yet very strenuous construction work activity, was evaluated biomechanically by studying electromyography (EMG) of the major neck muscles. The muscles studied were the sternocleidomastoid and the upper trapezius. Fifteen healthy participants (10 males and 5 females) with no history of musculoskeletal abnormalities participated in this study. The participants lifted 25%, 50%, and 75% of their maximum shoulder height static strength at neutral, maximally flexed, and maximally extended neck postures. The weight lifted as well as the neck posture significantly affected the activities of the neck muscles. Increase in the weight increased the activation of the …

School Health Fairs Show Potential To Improve Short-Term Learning, Marjorie Freedman

Faculty Publications

School-based health fairs, that include a variety of informational and/or “fun” booths, are examples of Level 1 interventions designed to build awareness of a health or nutritional topic or problem.1 Designing, implementing, and evaluating a health fair requires considerable resources. Yet recent examination of their efficacy in increasing knowledge is limited.2, 3 and 4 No research has been conducted on preadolescents, a group whose patterns of behavior and food choices may affect their current and future health status. Currently, almost one third of children and adolescents aged 2 to 19 are overweight or obese.5 Less than 10% of females and …

The Effects Of Theaflavin-Enriched Black Tea Extract On Muscle Soreness, Oxidative Stress, Inflammation, And Endocrine Responses To Acute Anaerobic Interval Training: A Randomized, Double-Blind, Crossover Study, Shawn M. Arent, Meghan Senso, Devon L. Golem, Kenneth H. Mckeever

Faculty Publications

Background: Muscle soreness and decreased performance often follow a bout of high-intensity exercise. By reducing these effects, an athlete can train more frequently and increase long-term performance. The purpose of this study is to examine whether a high-potency, black tea extract (BTE) alters the delayed onset muscle soreness (DOMS), oxidative stress, inflammation, and cortisol (CORT) responses to high-intensity anaerobic exercise.Methods: College-age males (N = 18) with 1+ yrs of weight training experience completed a double-blind, placebo-controlled, crossover study. Subjects consumed the BTE (1,760 mg BTE·d-1) or placebo (PLA) for 9 days. Each subject completed two testing sessions (T1 and T2), …

Development And Verification Of An Analytical Algorithm To Predict Absorbed Dose Distributions In Ocular Proton Therapy Using Monte Carlo Simulations, Nicholas C. Koch, Wayne D. Newhauser

Faculty Publications

Proton beam radiotherapy is an effective and non-invasive treatment for uveal melanoma. Recent research efforts have focused on improving the dosimetric accuracy of treatment planning and overcoming the present limitation of relative analytical dose calculations. Monte Carlo algorithms have been shown to accurately predict dose per monitor unit (D/MU) values, but this has yet to be shown for analytical algorithms dedicated to ocular proton therapy, which are typically less computationally expensive than Monte Carlo algorithms. The objective of this study was to determine if an analytical method could predict absolute dose distributions and D/MU values for a variety of treatment …

Dynamic Clamp: Alteration Of Response Properties And Creation Of Virtual Realities In Neurophysiology., Economo Mn, Fernandez Fr, White Ja

Faculty Publications

No abstract provided.