Digital Commons Network^™

Cost-Effectiveness Analysis Of Aducanumab Versus Placebo For Patients With Mild Cognitive Impairment And Mild Alzheimer’S Disease, Xiaomo Xiong, Gang Lv, Jacob Jordan King, Minghui Li, Jing Yuan, Z Kevin Lu

Faculty Publications

Objectives To assess the cost-effectiveness of aducanumab at its updated price for treating patients with mild cognitive impairment (MCI) and mild Alzheimer’s disease (AD).

Design Cost-effectiveness analysis.

Settings A five-state Markov model was constructed using 10 000 virtual patients to assess the cost-effectiveness of aducanumab from the perspective of the US healthcare system. The model employed a one-year cycle time and a lifetime time horizon. Transition probabilities and mortality rates were derived from a literature review. To address uncertainty and generalise the base case results, both one-way and probabilistic sensitivity analyses were conducted.

Participants 10 000 virtual patients with MCI …

Vocal And Articulatory Speech Control Deficits In Individuals With Post-Stroke Aphasia, Roozbeh Behroozmand, Zeinab Khoshhal Mollasaraei, Vahid Nejati, Ayoub Daliri, Julius Fridriksson Ph.D.

Faculty Publications

Individuals with post-stroke aphasia exhibit deficits in regulating vocal (i.e., laryngeal) pitch control during speech vowel production; however, it is not determined whether such deficits also exist when they control their supra-laryngeal speech articulators during word production. To address this question, 19 subjects with post-stroke aphasia and 20 controls were tested under an altered auditory feedback paradigm in which they received + 30% shifts in their vowel first-formant frequency during word production. In addition, 17 aphasia subjects and 19 controls from the same groups also completed steady vowel vocalizations while receiving randomized pitch shifts at ± 100 cents. Consistent with …

Human Capital And Lifetime Income Gains Of Scaling-Up Small-Quantity Lipid Nutrient Supplements Among Children Under 2 Years: A Modelling Analysis, Nandita Perumal Phd, Goodrarz Danaei, Günther Fink, Mark Lambiris, Christopher R. Sudfeld

Faculty Publications

Undernutrition in early childhood is associated with adverse health and developmental outcomes later in life and remains a persistent global public health problem. Providing small-quantity lipid nutrient supplements (SQ-LNS) to children aged 6-24 months improves child growth and neurodevelopmental outcomes, but the potential long-term benefits to human capital have not been previously estimated. We estimated the potential returns to schooling and lifetime income attributable to increasing coverage of SQ-LNS for children < 2 years of age from 0% to 50% or 90% per five-year birth cohort in five countries (Bangladesh, Burkina Faso, Ethiopia, Pakistan, and Uganda) with a high burden of undernutrition. Random-effects meta-analyses were used to estimate the effect of SQ-LNS on child development using evidence from randomized controlled trials, and to estimate the returns to lifetime income as a function of change in development based on a de novo meta-analysis of observational economic studies. Gains in school years attributable to scaling-up SQ-LNS to 90% coverage ranged from 0.14 million school years (95% uncertainty interval [UI]: 0.064, …

Leveraging Agent-Based Modeling And A Randomized Intervention To Advance Childhood Physical Activity: A Study Protocol, Matt Kasman, Adam B. Sedlak, Lydia Reader, William J. Heerman, Russell R. Pate, Amelie G. Ramirez, Evan C. Sommer, Shari L. Barkin, Ross A. Hammond

Faculty Publications

This study (1R01HD107002-01A1) protocol describes the planned creation and use of an agent-based model (ABM) of early childhood physical activity (PA). Successful early childhood PA interventions can potentially play an important role in both increasing overall population health as well as closing health disparities across subpopulations. At present, effective strategies for doing so are currently unknown. In large part, this is because PA determinants operate across levels dynamically, interact with one another, and can differ substantially across children. A complex systems approach—specifically, ABM—can be used to provide important insights about effect pathways driving child PA. Design of the proposed ABM …

Feature Typology And L2 Proficiency Matter: L3 Acquisition Of Portuguese, Mila Tasseva-Kurktchieva, Danielle Fahey

Faculty Publications

To determine the source of transfer in third language acquisition (L3A), we tested the effects of grammatical feature typology and L2 Spanish proficiency on the comprehension and production of grammatical [gender] and [number] in the early stages of L3A of Portuguese. We distinguish between the two features based on their participation in the lexical-conceptual structure of the lemma and its interaction with the morpho-syntactic derivation. L1 English speakers were tested on their knowledge of the features in both their L2 and their L3 through a grammaticality judgment task and an elicited production task. Results show that L3 learners transfer only …

Anchoring ‘Neo-Hahnian Outdoor Education’ In The Cold War Era: A History Of Character Building In The Outward Bound Movement, Jayson Seaman

Faculty Publications

The invitation to comment on a foundational early article from the JAEOL provided a welcome opportunity to engage with Andrew Brookes’s trilogy of ‘neo-Hahnian outdoor education’ critiques (Brookes, 2003a, 2003b, 2023). In this article, I approach outdoor education’s character building ideology by using archival and secondary sources to situate its evolution in four periods corresponding with major geopolitical and cultural movements: (1) 1941–1945 when Outward Bound (OB) was established; (2) 1946–1952 when Hahn exported OB from his perch at Gordonstoun; (3) 1953–1967 when OB expanded to the U.S. and replicated globally, and (4) 1968–1976 when human potentialism replaced muscular Christianity …

White Matter Integrity Of Hearing And Cognitive Impairments In Healthy Aging, Samaneh Nemati, Meisam Arjmandi M.Sc., Ph.D., Jean Neils-Strunjas Ph.D, Ccc-Slp, Roger Newman-Norlund Ph.D., Sarah Newman-Norlund B.S., M.A., Laura Droege, Leonardo Bonilha, Julius Fridriksson Ph.D.

Faculty Publications

Age-Related Hearing Loss (ARHL), or presbycusis, affects two-thirds of U.S. adults over 70 and is linked to cognitive decline and an increased risk of dementia. This study examines associations between white matter integrity and hearing and cognitive function in healthy aging using diffusion tensor imaging (DTI). We recruited 126 participants (92 female) aged 20–79 years () from the Aging Brain Cohort Study at the University of South Carolina (ABC@UofSC). Cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA), and hearing was evaluated through pure-tone thresholds (PTT) and words-in-noise (WIN) thresholds. White matter integrity was measured with fractional anisotropy (FA) …

Displaced Decarbonization: Climate Necropolitics And The Contested Spatialities Of Green Hydrogen In Namibia, Meredith J. Deboom

Faculty Publications

Green hydrogen is often presented as a transformative solution to the dual challenges of decarbonization and economic development. This article applies the framework of climate necropolitics to interrogate the contested spatialities underlying such “win-win” narratives. It does so through an extended case study of Hyphen Hydrogen Energy, a $10 billion green hydrogen project planned for Lüderitz, Namibia. A remote town of 20,000 in a country with a $12 billion annual GDP, Lüderitz initially appears to be an unlikely host site for the “industrial fuel of the future.” To explain this outcome, I first illustrate how discordant socio-spatial projects—including European energy …

Explaining Youth Driver Licensing Determinants Using Xgboost And Shap, Kailai Wang, Jonas De Vos, Michael Smart, Sicheng Wang

Faculty Publications

This study explores the factors influencing driver's license acquisition among young individuals and examines its broader implications for mobility, safety, and sustainability. Leveraging nationally representative survey data on Millennials and Generation Z, we apply eXtreme Gradient Boosting (XGBoost) and SHapley Additive Explanations (SHAP) to identify key socioeconomic determinants of teenage driver's license attainment. Our findings reveal consistent predictors across both generations, including the percentage of licensed family members, household income per capita, educational attainment, and public transit ridership. We identify meaningful dose-response relationships, such as the increasing influence of licensed household members beyond a 0.75 threshold and the …

Two-Layer Formulation For Long-Runout Turbidity Currents: Theory And Bypass Flow Case, Hongbo Ma, Gary Parker, Matthieu Cartigny, Enrica Viparelli, S. Balachandar, Xudong Fu, Rossella Luchi

Faculty Publications

Turbidity currents, which are stratified, sediment-laden bottom flows in the ocean or lakes, can run out for hundreds or thousands of kilometres in submarine channels without losing their stratified structure. Here, we derive a layer-averaged, two-layer model for turbidity currents, specifically designed to capture long-runout. A number of previous models have captured runout of only tens of kilometres, beyond which thickening of the flows becomes excessive, and the models without a lateral overspill mechanism fail. In our framework, a lower layer containing nearly all the sediment is a faster, gravity-driven flow that propels an upper layer, where sediment concentration is …

A Brave New World Of Human Resources Research: Navigating Perils And Identifying Grand Challenges Of The Genai Revolution, Anthony Nyberg, Deidra J. Schleicher, Bradford S. Bell, Corine Boon, Peter Cappelli, David G. Collings, Joseph E. Dalle Molle, Stefan Feuerriegel, Berry Gerhart, Yoojin Jeong, M. Audrey Korsgaard, Dana Minbaeva, Robert E. Ployhart, Prasanna Tambe, Ingo Weller, Patrick M. Wright, Valery Yakubovich

Faculty Publications

This paper reviews the transformative role of Generative Artificial Intelligence (GenAI) in Human Resource (HR) management, from a practice perspective, highlighting both opportunities and challenges and laying out a use-inspired future research agenda. This scoping review is grounded in insights from a unique Summit held in Spring 2024, which brought together HR academic scholars with dozens of Fortune 500 Chief Human Resource Officers (CHROs) and their top technical leaders to discuss the workforce implications of GenAI. The paper identifies six key themes from the Summit practitioners: GenAI as disruptive and transformative, data as competitive advantage, adoption challenges, potential ethical abuses, …

Average Biomechanical Responses Of The Human Brain Grouped By Age And Sex, Ahmed A. Alshareef, Aaron Carass, Yaun-Chiao Lu, Joy Mojumder, Alexa M. Diano, Olivia M. Bailey, Ruth J. Okamoto, Dzung L. Pham, Jerry L. Prince, Philip V. Bayly, Curtis L. Johnson

Faculty Publications

Traumatic brain injuries (TBIs) occur from rapid head motion that results in brain deformation. Computational models are typically used to estimate brain deformation to predict risk of injury and evaluate the effectiveness of safety countermeasures. The accuracy of these models relies on validation to experimental brain deformation data. In this study, we create the first group-average biomechanical responses of the brain, including structure, material properties, and deformation response, by age and sex from 157 subjects. Subjects were sorted intro three age groups—young, mid-age, and older—and by sex to create group-average neuroanatomy, material properties, and brain deformation response to non-injurious loading …

Examining Physiological Responses To Misophonic Triggers, Christian O'Reilly, Xuan Yang, Sewon Oh, Doug Wedell, Svetlana Shinkareva

Faculty Publications

We collected and analyzed an array of biosignals (face electromyogram, skin electrodermal activity, peripheral temperature, and electrocardiogram) in 60 participants with and without misophonia, a condition characterized by decreased tolerance to innocuous sounds. Our goal was to objectively characterize the physiological response to misophonia triggering sounds. We found that misophonic responses can be objectively identified in some cases through atypical physiological reactions to triggering stimuli, though not all participants exhibited this response. Our analyses suggest a large interindividual variability in response to misophonic triggers and highlights the need for methodological adjustments in future experiments to increase the detectability of misophonic …

Removing Eog Artifacts From Eeg Recordings Using Deep Learning, Christian O'Reilly, Scott Huberty

Faculty Publications

The electroencephalogram (EEG) directly measures the electrical activity generated by the brain. Unfortunately, it is often contaminated by various artifacts, notably those caused by eye movements and blinks (EOG artifacts). Such artifacts are usually removed using an independent component analysis (ICA) or other blind source separation techniques. However, it is difficult to assess whether subtracting EOG components estimated through ICA removes some neurogenic activity. It is crucial to address this question to avoid biasing EEG analyses. Toward that objective, we developed a deep learning model for EOG artifact removal that exploits information about eye movements available through eye-tracking (ET). Using …

A Reliable And Efficient Detection Pipeline For Rodent Ultrasonic Vocalizations, Sabah Shahnoor Anis, Devin Mark Kellis, Kris Ford Kaigler, Marlene A. Wilson, Christian O'Reilly

Faculty Publications

Analyzing ultrasonic vocalizations (USVs) is crucial for understanding rodents' affective states and social behaviors, but the manual analysis is time-consuming and prone to errors. Automated USV detection systems have been developed to address these challenges. Yet, these systems often rely on machine learning and fail to generalize effectively to new datasets. To tackle these shortcomings, we introduce ContourUSV, an efficient automated system for detecting USVs from audio recordings. Our pipeline includes spectrogram generation, cleaning, pre-processing, contour detection, post-processing, and evaluation against manual annotations. To ensure robustness and reliability, we compared ContourUSV with three state-of-the-art systems using an existing open-access USV …

Deep Jansen-Rit Parameter Inference For Model-Driven Analysis Of Brain Activity, Deepa Tilwani, Christian O'Reilly

Faculty Publications

Accurately modeling effective connectivity (EC) is critical for understanding how the brain processes and integrates sensory information. Yet, it remains a formidable challenge due to complex neural dynamics and noisy measurements such as those obtained from the electroencephalogram (EEG). Model-driven EC infers local (within a brain region) and global (between brain regions) EC parameters by fitting a generative model of neural activity onto experimental data. This approach offers a promising route for various applications, including investigating neurodevel- opmental disorders. However, current approaches fail to scale to whole-brain analyses and are highly noise-sensitive. In this work, we employ three deep-learning architectures—a …

Open Accessarticle Crystal Plasticity Modeling Of Dislocation Density Evolution In Cellular Dislocation Structures, Md Mahabubur Rohoman, Caizhi Zhou

Faculty Publications

The complex thermal cycles during the solidification process in metal additive manufacturing (AM) lead to the formation of high-density dislocation networks, organizing into submicron-scale cellular structures. These ultrafine structures are recognized as crucial for enhancing the mechanical properties of AM metals. In this study, we investigate the evolution of dislocation density within these cellular structures under plastic deformation and its impact on mechanical response using dislocation density-based crystal plasticity finite element (CPFE) modeling. The model incorporates the evolution of both statistically stored dislocation (SSD) and geometrically necessary dislocation (GND). Our simulations reveal that the yield and flow stresses of dislocation …

“They Are Fat And Want Special Treatment For Being Fat”: Backlash To And Lay Theories Of Fat Activism, Flora Blanchette-Oswald, Minh Duc Pham, R. J. Harr, Alexandra Garr-Schultz, Kimberly E. Chaney

Faculty Publications

Fat activism is a movement that seeks to acknowledge and eliminate the oppression of fat people. The movement and those who participate face significant backlash, yet fat activism is understudied. We sought to understand lay theories about fat activism; that is, how everyday people think about the goals and motivations of fat activism, and people who engage in fat activism, to understand how these perceptions shape support for and backlash toward fat activism. In Study 1 (N = 294), we qualitatively elucidated lay theories of fat activism in a US nationally representative sample. We identified lay theories that both …

Hedging Energy Transition: Green Hydrogen, Oil, And Low-Carbon Resilience As State Strategy In Namibia, Meredith J. Deboom

Faculty Publications

Policy frameworks increasingly portray energy transition as a mechanism for achieving a range of resilience- related goals, including socio-economic development and energy security. Energy transition is often character ized as a particularly important resilience strategy for lower-income states in the Global South, which face the simultaneous challenges of decarbonization and development. Yet these states, many of which have fossil fuel resources, face distinct constraints and risks in navigating energy transition, including the possibility that promised funding for low-carbon energy projects will never come to fruition or that global decarbonization will be deferred or abandoned completely. This article uses the case …

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …

Tobacco Package Health Warnings About Product Manipulations: An Experimental Study Among Australian Adults Who Smoke, Emily Brennan, Claudia Gascoyne, Kimberley Dunstone, Amanda Vittiglia, Gayathri Srinivasan, Jim Thrasher Ph.D., Ma, Ms, Janet Hoek, Melanie Wakefield, Sarah Durkin

Faculty Publications

The tobacco industry manipulates cigarettes to provide sensory cues that mislead people who smoke. We assessed the effectiveness of health warnings (HWs) focussed on the impact of misleading product attributes, including filter ventilation, menthol, and roll-your-own tobacco, which were called Product Attribute HWs. Australian adults who smoke (n = 2544) were randomly assigned to view: control medication warnings; new Standard HWs with smoking harm images; Product Attribute HWs; or Product Attribute HWs plus a video. At baseline, participants were exposed to seven condition-specific warnings (+ video for those in the Product Attribute HWs + Video condition), then they were …

Research Priorities For Drivers Of Food Choice For Food System Transformation In South Asia: Proceedings Of A Collaborative Workshop, Christine E. Blake Ph.D., Rd, Sunny S. Kim, Edward A. Frongillo Ph.D., Purnima Menon

Faculty Publications

Agrifood systems in South Asia are highly productive, but substantial challenges including poverty, climate change, and environmental degradation complicate progress toward achieving sustainable healthy diets for all. The dynamics of food systems and the consequence of their rapid transformation for food choice behaviors that contribute to healthy and unhealthy diets are not well understood. Food choice is defined as a decision-making process through which individuals and households consider, acquire, prepare, distribute, and consume foods and beverages. Understanding drivers of food choice (DFC) is important for achieving sustainable healthy diets, but evidence is lacking. This article outlines collectively derived priorities for …

Telehealth Or In-Person Hiv Care? Qualitative Study Findings On Decision-Making From People With Hiv And Hiv Care Providers In South Carolina During The Covid-19 Pandemic, Valerie Yelverton, Salome Joelle Gass, Daniel Amoatika, Christopher Cooke, Jan Ostermann, Nabil Natafgi, Nicole L. Hair Ph.D., Bankole Olatosi Ph.D., Otis L. Owens, Shan Qiao Ph.D., Xiaoming Li Ph.D., Caroline Derrick, Sharon Weissman, Helmut Albrecht

Faculty Publications

The COVID-19 pandemic disrupted HIV care services across the United States. Telehealth was rapidly implemented to ensure HIV care continuity. Despite the evidence of unequal telehealth uptake among some people with HIV (PWH), the decision-making processes to determine who received telehealth or in-person care are under-researched. This study assessed which decision criteria and processes determined which HIV care visit type was used by PWH and HIV care providers during the COVID-19 pandemic. Qualitative in-depth interviews with 18 PWH and 10 HIV care providers from South Carolina assessed PWHs’ and HIV care providers’ decision-making criteria and processes for telehealth HIV care …

Adipocyte-Derived Cchamide-1, Eiger, Growth-Blocking Peptide 3, And Unpaired 2 Regulate Drosophila Melanogaster Oogenesis, Chad Simmons, Isaiah Williams, Tancia Bradshaw, Alissa R. Armstrong

Faculty Publications

In addition to energy storage, adipose tissue communication to other organs plays a key role in regulating organismal physiology. While the link between adipose tissue dysfunction and pathophysiology, including diabetes, chronic inflammation, and infertility, is clear, the molecular mechanisms that underlie these associations have not been fully described. We use Drosophila melanogaster as a model to better understand how adipose tissue communicates to the ovary. In this study, we utilized D. melanogaster’s robust genetic toolkit to examine the role of five adipokines known to control larval growth during development, CCHamide-1, CCHamide-2, eiger, Growth-blocking peptide 3, and unpaired 2 in regulating …

Endothelial Dysfunction Promotes Age-Related Reorganization Of Collagen Fibers And Alters Aortic Biomechanics In Mice, Liya Du, Jeffrey Rodgers, Nazli Gharraee, Olivia Gary, Tarek Shazly, John F. Eberth, Susan M. Lessner

Faculty Publications

Endothelial dysfunction, defined as a reduction in the bioavailability of nitric oxide (NO), is a risk factor for the occurrence and progression of various vascular diseases. This study investigates the effect of endothelial dysfunction on age-related changes in aortic extracellular matrix (ECM) microstructure and the relationship between microstructural adaptation and the mechanical response. Here, we used groups of NOS3 knockout (KO), NOS3 heterozygotes (Het), and wild-type (WT) B6 mice (controls) to study changes in hemodynamic parameters, collagen fiber organization, and both active and passive aortic mechanics using biaxial pressure myography over a time course from 1.5 to 12 mo. Our …

Kinetic Control And Trapping In The Supramolecular Polymerization Of M-Terphenyl Bis-Urea Macrocycles, Sophya V. Garashchuk, Gamage Isuri P. Wijesekera, Isabella G. Rushton, Vaibhavi A. Samant, Fahidat A. Gbadamosi, Dr. Md Faizul Islam, Sophya V. Garashchuk, Prof. Dr. Linda S. Shimizu

Faculty Publications

Herein, we examine pathway complexity in the supramolecular polymerization of a novel m-terphenyl bis-urea macrocycle. Designed to induce kinetically metastable states, the macrocycle‘s concentration-dependent aggregation was studied via 1H NMR and IR spectroscopy in THF and CHCl₃. Temperature-dependent UV-Vis spectroscopy in water/THF revealed a cooperative nucleation-growth mechanism, indicated by a shift in λmax to longer wavelengths upon cooling. Morphological studies using DLS, AFM, and SEM demonstrated fibrous aggregate formation. Thermal hysteresis observed in assembly-disassembly cycles indicated kinetically trapped species, with cooling governed by kinetic control and heating by thermodynamic processes. Deviations in ΔH values during cooling, compared to van′t …

Shear-Thinning Hydrogel For Delayed Delivery Of A Small Molecule Metalloproteinase Inhibitor Attenuates Myocardial Infarction Remodeling, Joshua E. Mealy, William M. Torres, Lisa A. Freeburg, Shayne C. Barlow, Alison A. Whalen, Chima V. Maduka, Tarek Shazly, Jason A. Burdick, Francis G. Spinale

Faculty Publications

No abstract provided.

Ultrasonic Spray Coating Of Carbon Fibers For Composite Cathodes In Structural Batteries, Thomas Burns, Liliana Delatte, Gabriela Roman-Martinez, Kyra Glassey, Paul Ziehl, Monirosadat Sadati, Ralph E. White, Paul T. Coman

Faculty Publications

Structural batteries, also known as “massless batteries”, integrate energy storage directly into load-bearing materials, offering a transformative alternative to traditional Li-ion batteries. Unlike conventional systems that serve only as energy storage devices, structural batteries replace passive structural components, reducing overall weight while providing mechanical reinforcement. However, achieving uniform and efficient coatings of active materials on carbon fibers remains a major challenge, limiting their scalability and electrochemical performance. This study investigates ultrasonic spray coating as a precise and scalable technique for fabricating composite cathodes in structural batteries. Using a computer-controlled ultrasonic nozzle, this method ensures uniform deposition with minimal material waste …

Adipocyte-Derived Cchamide-1, Eiger, Growth-Blocking Peptide 3, And Unpaired 2 Regulate Drosophila Melanogaster Oogenesis, Chad Simmons, Isaiah H. Williams, Tancia W. Bradshaw, Alissa R. Armstrong

Faculty Publications

In addition to energy storage, adipose tissue communication to other organs plays a key role in regulating organismal physiology. While the link between adipose tissue dysfunction and pathophysiology, including diabetes, chronic inflammation, and infertility, is clear, the molecular mechanisms that underlie these associations have not been fully described. We use Drosophila melanogaster as a model to better understand how adipose tissue communicates to the ovary. In this study, we utilized D. melanogaster’s robust genetic toolkit to examine the role of five adipokines known to control larval growth during development, CCHamide-1, CCHamide-2, eiger, Growth-blocking peptide 3, and unpaired 2 in regulating …

A Hybrid Type I Randomized Effectiveness-Implementation Trial Of A Naturalistic Developmental Behavioral Intervention In The Part C Early Intervention System: Study Protocol, Allison L. Wainer, Sarah Edmunds, Alice S. Carter, Wendy L. Stone, R. Christopher Sheldrick, Sarabeth Broder-Fingert, Yael S. Stern, Ellie Harrington, Lisa V. Ibanez, Brooke Ingersoll

Faculty Publications

Background

Participation in Naturalistic Developmental Behavioral Interventions (NDBI) is associated with significant improvements in functioning for toddlers with, and showing early signs of, autism spectrum disorder. The Part C Early Intervention (EI) system, which is publicly funded and available in all U.S. states, offers an optimal infrastructure through which toddlers can receive NDBIs. This study seeks to assess the effectiveness and fit of one NDBI, Caregiver Implemented Reciprocal Imitation Teaching (CI-RIT), within the Part C EI system.

Methods

This hybrid type 1 effectiveness/implementation trial uses a multi-site randomized control design to simultaneously test effectiveness and collect implementation data on CI-RIT …