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Articles 241 - 270 of 6810
Full-Text Articles in Entire DC Network
Allura Red Ac Is A Xenobiotic. Is It Also A Carcinogen?, Lorne J. Hofseth Ph.D., James Hébert Scd, Elizabeth Angela Murphy, Erica Trauner, Athul Vikas, Quinn Harris, Alexander A. Chumanevich
Allura Red Ac Is A Xenobiotic. Is It Also A Carcinogen?, Lorne J. Hofseth Ph.D., James Hébert Scd, Elizabeth Angela Murphy, Erica Trauner, Athul Vikas, Quinn Harris, Alexander A. Chumanevich
Faculty Publications
Merriam-Webster and Oxford define a xenobiotic as any substance foreign to living systems. Allura Red AC (a.k.a., E129; FD&C Red No. 40), a synthetic food dye extensively used in manufacturing ultra-processed foods and therefore highly prevalent in our food supply, falls under this category. The surge in synthetic food dye consumption during the 70s and 80s was followed by an epidemic of metabolic diseases and the emergence of early-onset colorectal cancer in the 1990s. This temporal association raises significant concerns, particularly given the widespread inclusion of synthetic food dyes in ultra-processed products, notably those marketed toward children. Given its interactions …
Allura Red Ac Is A Xenobiotic. Is It Also A Carcinogen?, Lorne J. Hofseth, James R. Hébert Scd, Elizabeth Angela Murphy, Erica Trauner, Athul Vikas, Quinn Harris, Alexander A. Chumanevich
Allura Red Ac Is A Xenobiotic. Is It Also A Carcinogen?, Lorne J. Hofseth, James R. Hébert Scd, Elizabeth Angela Murphy, Erica Trauner, Athul Vikas, Quinn Harris, Alexander A. Chumanevich
Faculty Publications
Merriam-Webster and Oxford define a xenobiotic as any substance foreign to living systems. Allura Red AC (a.k.a., E129; FD&C Red No. 40), a synthetic food dye extensively used in manufacturing ultra-processed foods and therefore highly prevalent in our food supply, falls under this category. The surge in synthetic food dye consumption during the 70s and 80s was followed by an epidemic of metabolic diseases and the emergence of early-onset colorectal cancer in the 1990s. This temporal association raises significant concerns, particularly given the widespread inclusion of synthetic food dyes in ultra-processed products, notably those marketed toward children. Given its interactions …
Return To Eden: God’S Design For Human Sexuality In The Song Of Songs, Richard M. Davidson
Return To Eden: God’S Design For Human Sexuality In The Song Of Songs, Richard M. Davidson
Faculty Publications
No abstract provided.
The Elephant In The Dark Room: A Response To Fair Notice, The Rule Of Law And Reforming Qualified Immunity, Teressa E. Ravenell
The Elephant In The Dark Room: A Response To Fair Notice, The Rule Of Law And Reforming Qualified Immunity, Teressa E. Ravenell
Faculty Publications
In response to Professor Chapman’s Fair Notice, the Rule of Law, and Reforming Qualified Immunity, this article examines the viability of Chapman’s proposal to reform qualified immunity by focusing on the “fair notice” rationale. Chapman argues that government officials should not be shielded from liability in cases where they acted in bad faith, violated criminal laws, or engaged in conduct malum in se. This article explores whether such a proposal could meaningfully alter qualified immunity litigation and concludes that significant procedural and historical barriers make this reform unlikely to succeed.
Removal Of Common Antimicrobial Agents By Sustained Low- Efficiency Dialysis, Joanna Q. Hudson Pharmd, Bcps, Fasn, Fccp, Madelyn N. Hilgers Bs, Pharmd Candidate, Elvira O. Gosmanova Md
Removal Of Common Antimicrobial Agents By Sustained Low- Efficiency Dialysis, Joanna Q. Hudson Pharmd, Bcps, Fasn, Fccp, Madelyn N. Hilgers Bs, Pharmd Candidate, Elvira O. Gosmanova Md
Faculty Publications
Adequate dosing of antimicrobials is paramount for treating infections in critically ill patients undergoing kidney replacement therapy; however, little is known about antimicrobial removal by sustained low-efficiency dialysis (SLED). The objective was to quantify the removal of cefepime, daptomycin, meropenem, piperacillin–tazobactam, and vancomycin in patients undergoing SLED. Adult patients ≥18 years with acute kidney injury (AKI) or end-stage kidney disease receiving one of the select antimicrobials and requiring SLED were included. Blood and dialysate flow rates were maintained at 250 and 100 mL/min, respectively. Simultaneous arterial and venous blood samples for the analysis of antibiotic concentrations were collected hourly for …
Footprint Tools Tiptoeing Towards Nitrogen Sustainability, James N. Galloway, Elizabeth A. Castner, Elizabeth S M Dukes, Jessica Fox, Allison M. Leach
Footprint Tools Tiptoeing Towards Nitrogen Sustainability, James N. Galloway, Elizabeth A. Castner, Elizabeth S M Dukes, Jessica Fox, Allison M. Leach
Faculty Publications
As we face multiple environmental crises (e.g. climate change, nutrient pollution, freshwater scarcity), there is often a disconnect between an entity’s activities and the pollution resulting from that activity. Footprint tools help address this disconnect. They are effective in educating people, institutions and communities on how their resource use results in environmental pollution and what we can do to moderate that pollution. These tools connect an entity’s activities with the associated pollution. Footprint tools are also constantly evolving. As we better understand how to best estimate emissions—especially from sources further removed like those from the supply chain—the guidance and methods …
Footprint Tools Tiptoeing Towards Nitrogen Sustainability, James N. Galloway, Elizabeth A. Castner, Elizabeth S M Dukes, Jessica Fox, Allison M. Leach
Footprint Tools Tiptoeing Towards Nitrogen Sustainability, James N. Galloway, Elizabeth A. Castner, Elizabeth S M Dukes, Jessica Fox, Allison M. Leach
Faculty Publications
As we face multiple environmental crises (e.g. climate change, nutrient pollution, freshwater scarcity), there is often a disconnect between an entity’s activities and the pollution resulting from that activity. Footprint tools help address this disconnect. They are effective in educating people, institutions and communities on how their resource use results in environmental pollution and what we can do to moderate that pollution. These tools connect an entity’s activities with the associated pollution. Footprint tools are also constantly evolving. As we better understand how to best estimate emissions—especially from sources further removed like those from the supply chain—the guidance and methods …
Beyond Covid: Towards A Transdisciplinary Synthesis For Understanding Responses And Developing Pandemic Preparedness In Alaska, Taylor P. Van Doren, Ryan A. Brown, Guangqing Chi, Patricia Cochran, Katie Cueva, Laura Eichelberger, Ruby Fried, Stacey Fritz, Micah B. Hahn, Ron Heintz, Davin Holen, Andrey N. Petrov
Beyond Covid: Towards A Transdisciplinary Synthesis For Understanding Responses And Developing Pandemic Preparedness In Alaska, Taylor P. Van Doren, Ryan A. Brown, Guangqing Chi, Patricia Cochran, Katie Cueva, Laura Eichelberger, Ruby Fried, Stacey Fritz, Micah B. Hahn, Ron Heintz, Davin Holen, Andrey N. Petrov
Faculty Publications
Pandemics are regularly occurring events, and there are foundational principles of pandemic preparation upon which communities, regions, states, and nations may draw upon for elevated preparedness against an inevitable future infectious disease threat. Many disciplines within the social sciences can provide crucial insight and transdisciplinary thinking for the development of preparedness measures. In 2023, the National Science Foundation funded a conference of circumpolar researchers and Indigenous partners to reflect on COVID-19-related research. In this article, we synthesise our diverse social science perspectives to: (1) identify potential areas of future pandemic-related research in Alaska, and (2) pose new research questions that …
Early Preclinical Studies Of Ergosterol Peroxide And Biological Evaluation Of Its Derivatives, Taotao Ling, Luz V. Arroyo-Cruz, William R. Smither, Emily K. Seighman, Michelle M. Martínez-Montemayor, Fatima Rivas
Early Preclinical Studies Of Ergosterol Peroxide And Biological Evaluation Of Its Derivatives, Taotao Ling, Luz V. Arroyo-Cruz, William R. Smither, Emily K. Seighman, Michelle M. Martínez-Montemayor, Fatima Rivas
Faculty Publications
Ganoderma lucidum is a medicinal mushroom that produces various pharmacological compounds, including triterpenoids. A major bioactive component of G. lucidum is ergosterol peroxide (EP), which is attributed to its anticancer effects. The current study focuses on the in vitro ADME (absorption, distribution, metabolism, and elimination), in vivo efficacy and toxicity of EP, and the synthesis of new EP derivatives to improve aqueous solubility. It was found that EP is metabolically stable in liver microsomes and plasma. In vivo studies showed that EP inhibits tumor growth in murine cancer models, and it is well tolerated by mice. The maximum tolerated dose …
The Past And Future Of The Fisheries And Marine Ecosystem Model Intercomparison Project, Camilla Novaglio, Andrea Bryndum-Buchholz, Derek P. Tittensor, Tyler D. Eddy, Heike K. Lotze, Cheryl S. Harrison, Ryan F. Heneghan, Olivier Maury, Kelly Ortega-Cisneros, Colleen M. Petrik, Kelsey E. Roberts, Julia L. Blanchard
The Past And Future Of The Fisheries And Marine Ecosystem Model Intercomparison Project, Camilla Novaglio, Andrea Bryndum-Buchholz, Derek P. Tittensor, Tyler D. Eddy, Heike K. Lotze, Cheryl S. Harrison, Ryan F. Heneghan, Olivier Maury, Kelly Ortega-Cisneros, Colleen M. Petrik, Kelsey E. Roberts, Julia L. Blanchard
Faculty Publications
Climate change is increasingly affecting the world's ocean ecosystems, necessitating urgent guidance on adaptation strategies to limit or prevent catastrophic impacts. The Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP) is a network and framework that provides standardised ensemble projections of the impacts of climate change and fisheries on ocean life and the benefits that it provides to people. Since its official launch in 2013 as a small, self-organized project within the larger Inter-Sectoral Impact Model Intercomparison Project, the FishMIP community has grown substantially and contributed to key international policy processes, such as the Intergovernmental Panel on Climate Change Assessment …
Far From Their Origins: A Transcriptomic Investigation On How 2,4-Di-Tert-Butyl-6-(5-Chloro-2h-Benzotriazol-2-Yl) Phenol Affects Rainbow Trout Alevins, Andreas N.M. Eriksson, Justin Dubiel, Alper James Alcaraz, Jon A. Doering, Steve Wiseman
Far From Their Origins: A Transcriptomic Investigation On How 2,4-Di-Tert-Butyl-6-(5-Chloro-2h-Benzotriazol-2-Yl) Phenol Affects Rainbow Trout Alevins, Andreas N.M. Eriksson, Justin Dubiel, Alper James Alcaraz, Jon A. Doering, Steve Wiseman
Faculty Publications
Benzotriazole ultraviolet stabilizers (BUVSs) are a group of widely used chemicals added to a variety of consumer (e.g., plastics) and industrial (e.g., metal coating) goods. Although detected globally as an environmentally persistent pollutant, BUVSs have received relatively little toxicological attention and only recently have been acknowledged to affect development and the endocrine system in vivo. In our previous study, altered behavior, indicative of potential neurotoxicity, was observed among rainbow trout alevins (day 14 posthatching) that were microinjected as embryos with a single environmentally relevant dose of 2,4-di-tert-butyl–6-(5-chloro-2H-benzotriazol-2-yl) phenol (UV-327). In the present follow-up study, we performed whole-transcriptome profiling (RNA sequencing) …
Reconstructive Evolutionary Morphology: Tracing The Historical Process Of Modifications Of Complex Systems Driven By Natural Selection Through Changing Ecological Conditions, Dominique G. Homberger
Reconstructive Evolutionary Morphology: Tracing The Historical Process Of Modifications Of Complex Systems Driven By Natural Selection Through Changing Ecological Conditions, Dominique G. Homberger
Faculty Publications
There is general consensus among evolutionary biologists that natural selection drives phenotypic modifications within populations over generational time. How to reconstruct this historical process, however, has been discussed mostly in theoretical terms, and recommendations and explanations on how to translate such theoretical insights into practice are needed. The present study aims at providing a theory-supported practical guide on how to reconstruct historical evolutionary processes by applying a morphology-centered approach through a series of interdependent steps of descriptive morphology, functional analysis, ecological observation, integration of paleoecological data, and evolutionary synthesis. Special attention is given to the development of tests regarding the …
Toward A Comparative Framework For Studies Of Altitudinal Migration, David Vander Pluym, Nicholas A. Mason
Toward A Comparative Framework For Studies Of Altitudinal Migration, David Vander Pluym, Nicholas A. Mason
Faculty Publications
The study and importance of altitudinal migration has attracted increasing interest among zoologists. Altitudinal migrants are taxonomically widespread and move across altitudinal gradients as partial or complete migrants, subjecting them to a wide array of environments and ecological interactions. Here, we present a brief synthesis of recent developments in the field and suggest future directions toward a more taxonomically inclusive comparative framework for the study of altitudinal migration. Our framework centers on a working definition of altitudinal migration that hinges on its biological relevance, which is scale-dependent and related to fitness outcomes. We discuss linguistic nuances of altitudinal movements and …
A Review Of Agrivoltaic Systems: Addressing Challenges And Enhancing Sustainability, Amro A. Zahrawi, Aly Mousaad Aly
A Review Of Agrivoltaic Systems: Addressing Challenges And Enhancing Sustainability, Amro A. Zahrawi, Aly Mousaad Aly
Faculty Publications
Agrivoltaics is a relatively new term used originally for integrating photovoltaic (PV) systems into the agricultural landscape and expanded to applications such as animal farms, greenhouses, and recreational parks. The dual use of land offers multiple solutions for the renewable energy sector worldwide, provided it can be implemented without negatively impacting agricultural production. However, agrivoltaics represent a relatively new technology, facing challenges including economic viability, vulnerability to wind loads, and interference with growing crops. This paper reviews the recent research on integrating agrivoltaics with farming applications, focusing on challenges, wind impact on agrivoltaics, and economic solutions. The effect of agrivoltaics …
Shifting Baselines: Visualizing Climate Change In America’S National Parks, Lee Lines
Shifting Baselines: Visualizing Climate Change In America’S National Parks, Lee Lines
Faculty Publications
No abstract provided.
The Politics Of Heritage And Indigeneity In Assam: Hindutva’S Regional Expression, Tahmina Rahman
The Politics Of Heritage And Indigeneity In Assam: Hindutva’S Regional Expression, Tahmina Rahman
Faculty Publications
No abstract provided.
Why Are There So Many Definitions Of Eutrophication?, Alexandrine Pannard, Philippe Souchu, Christian Chauvin, Monique Delabuis, Chantal Gascuel-Odoux, Erik Jeppesen, Morgane Le Moal, Alain Ménesguen, Gilles Pinay, Nancy N. Rabalais, Yves Souchon, Elisabeth M. Gross
Why Are There So Many Definitions Of Eutrophication?, Alexandrine Pannard, Philippe Souchu, Christian Chauvin, Monique Delabuis, Chantal Gascuel-Odoux, Erik Jeppesen, Morgane Le Moal, Alain Ménesguen, Gilles Pinay, Nancy N. Rabalais, Yves Souchon, Elisabeth M. Gross
Faculty Publications
Because of the first observations in the 1900s of the oligotrophic and eutrophic states of lakes, researchers have been interested in the process that makes lakes become turbid because of high phytoplankton biomass. Definitions of eutrophication have multiplied and diversified since the mid-20th century, more than for any other ecological process. Reasons for the high number of definitions might be that the former ones did not sufficiently describe their causes and/or consequences. Global change is bringing eutrophication more into the spotlight than ever, highlighting the need to find consensus on a common definition, or at least to explain and clarify …
Key Uncertainties And Modeling Needs For Managing Living Marine Resources In The Future Arctic Ocean, Julia G. Mason, Andrea Bryndum-Buchholz, Juliano Palacios-Abrantes, Renuka Badhe, Isabella Morgante, Daniele Bianchi, Julia L. Blanchard, Jason D. Everett, Cheryl S. Harrison, Ryan F. Heneghan, Camilla Novaglio, Colleen M. Petrik
Key Uncertainties And Modeling Needs For Managing Living Marine Resources In The Future Arctic Ocean, Julia G. Mason, Andrea Bryndum-Buchholz, Juliano Palacios-Abrantes, Renuka Badhe, Isabella Morgante, Daniele Bianchi, Julia L. Blanchard, Jason D. Everett, Cheryl S. Harrison, Ryan F. Heneghan, Camilla Novaglio, Colleen M. Petrik
Faculty Publications
Emerging fishing activity due to melting ice and poleward species distribution shifts in the rapidly-warming Arctic Ocean challenges transboundary management and requires proactive governance. A 2021 moratorium on commercial fishing in the Arctic high seas provides a 16-year runway for improved scientific understanding. Given substantial knowledge gaps, characterizing areas of highest uncertainty is a key first step. Marine ecosystem model ensembles that project future fish distributions could inform management of future Arctic fisheries, but Arctic-specific variation has not yet been examined for global ensembles. We use the Fisheries and Marine Ecosystem Intercomparison Project ensemble driven by two Earth System Models …
Solubilization Of Paclitaxel With Natural Compound Rubusoside Toward Improving Oral Bioavailability In A Rodent Model, Jian Zhang, Jicheng Shu, Rhett W. Stout, Paul S. Russo, Zhijun Liu
Solubilization Of Paclitaxel With Natural Compound Rubusoside Toward Improving Oral Bioavailability In A Rodent Model, Jian Zhang, Jicheng Shu, Rhett W. Stout, Paul S. Russo, Zhijun Liu
Faculty Publications
Paclitaxel, which features low water solubility and permeability, is an efflux pump substrate. The current paclitaxel drugs are given intravenously after resolving the solubility issue. Yet, oral delivery to achieve therapeutic bioavailability is not effective due to low absorption. This study evaluated a natural compound, rubusoside, to improve oral bioavailability in an animal model. Free paclitaxel molecules were processed into nano-micelles formed in water with rubusoside. The particle size of the nano-micelles in water was determined using dynamic light scattering. The oral bioavailability of paclitaxel in nano-micelles was determined against Cremophor/alcohol-solubilized Taxol after oral and intravenous administration to pre-cannulated Sprague …
Response Of A Terrestrial Polar Ecosystem To The March 2022 Antarctic Weather Anomaly, J. E. Barrett, Byron J. Adams, Peter T. Doran, Hilary A. Dugan, Krista F. Myers, Mark R. Salvatore, Sarah N. Power, Meredith D. Snyder, Anna T. Wright, Michael N. Gooseff
Response Of A Terrestrial Polar Ecosystem To The March 2022 Antarctic Weather Anomaly, J. E. Barrett, Byron J. Adams, Peter T. Doran, Hilary A. Dugan, Krista F. Myers, Mark R. Salvatore, Sarah N. Power, Meredith D. Snyder, Anna T. Wright, Michael N. Gooseff
Faculty Publications
Record high temperatures were documented in the McMurdo Dry Valleys, Antarctica, on 18 March 2022, exceeding average temperatures for that day by nearly 30°C. Satellite imagery and stream gage measurements indicate that surface wetting coincided with this warming more than 2 months after peak summer thaw and likely exceeded thresholds for rehydration and activation of resident organisms that typically survive the cold and dry conditions of the polar fall in a freeze-dried state. This weather event is notable in both the timing and magnitude of the warming and wetting when temperatures exceeded 0°C at a time when biological communities and …
Effects Of Exercise Or Metformin On Myokine Concentrations In Patients With Breast And Colorectal Cancer: A Phase Ii Multi-Centre Factorial Randomized Trial, Justin C. Brown, Guillaume Spielmann, Shengping Yang, Stephanie L.E. Compton, Lee W. Jones, Melinda L. Irwin, Jennifer A. Ligibel, Jeffrey A. Meyerhardt
Effects Of Exercise Or Metformin On Myokine Concentrations In Patients With Breast And Colorectal Cancer: A Phase Ii Multi-Centre Factorial Randomized Trial, Justin C. Brown, Guillaume Spielmann, Shengping Yang, Stephanie L.E. Compton, Lee W. Jones, Melinda L. Irwin, Jennifer A. Ligibel, Jeffrey A. Meyerhardt
Faculty Publications
Background: Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations. Methods: This hypothesis-generating analysis used biospecimens collected from a multi-centre 2 × 2 factorial randomized design of 116 patients with stage I–III breast and colorectal cancer who were randomized to 12 weeks of (1) aerobic exercise (moderate intensity titrated to 220 min/week); (2) metformin (850 mg daily for 2 weeks and then titrated to 850 mg twice per day); (3) aerobic exercise and metformin; or (4) control. Fourteen myokines were …
Boron Neutron Capture Therapy Of Cancer: Where Do We Stand Now?, Rolf F. Barth, Gong Wu, Maria Da Graca H. Vicente, John C. Grecula, Nilendu Gupta
Boron Neutron Capture Therapy Of Cancer: Where Do We Stand Now?, Rolf F. Barth, Gong Wu, Maria Da Graca H. Vicente, John C. Grecula, Nilendu Gupta
Faculty Publications
No abstract provided.
Lipids To The Rescue In Pulmonary Fibrosis: Biosynthesis, Bioenergetics, Or Epigenetics?, Manas Ranjan Gartia, Victor J. Thannickal
Lipids To The Rescue In Pulmonary Fibrosis: Biosynthesis, Bioenergetics, Or Epigenetics?, Manas Ranjan Gartia, Victor J. Thannickal
Faculty Publications
No abstract provided.
Hyperpolarized Magnetic Resonance Imaging, Nuclear Magnetic Resonance Metabolomics, And Artificial Intelligence To Interrogate The Metabolic Evolution Of Glioblastoma, Kang Lin Hsieh, Qing Chen, Travis C. Salzillo, Jian Zhang, Xiaoqian Jiang, Pratip K. Bhattacharya, Shyan Shams
Hyperpolarized Magnetic Resonance Imaging, Nuclear Magnetic Resonance Metabolomics, And Artificial Intelligence To Interrogate The Metabolic Evolution Of Glioblastoma, Kang Lin Hsieh, Qing Chen, Travis C. Salzillo, Jian Zhang, Xiaoqian Jiang, Pratip K. Bhattacharya, Shyan Shams
Faculty Publications
Glioblastoma (GBM) is a malignant Grade VI cancer type with a median survival duration of only 8–16 months. Earlier detection of GBM could enable more effective treatment. Hyperpolarized magnetic resonance spectroscopy (HPMRS) could detect GBM earlier than conventional anatomical MRI in glioblastoma murine models. We further investigated whether artificial intelligence (A.I.) could detect GBM earlier than HPMRS. We developed a deep learning model that combines multiple modalities of cancer data to predict tumor progression, assess treatment effects, and to reconstruct in vivo metabolomic information from ex vivo data. Our model can detect GBM progression two weeks earlier than conventional MRIs …
The Impact Of Lutein-Loaded Poly(Lactic-Coglycolic Acid) Nanoparticles Following Topical Application: An In Vitro And In Vivo Study, Renee T. Carter, Sean Swetledge, Sara Navarro, Chin C. Liu, Nikole Ineck, Andrew C. Lewin, Fabrizio Donnarumma, Ede Bodoki, Rhett W. Stout, Carlos Astete, Jangwook P. Jung, Cristina M. Sabliov
The Impact Of Lutein-Loaded Poly(Lactic-Coglycolic Acid) Nanoparticles Following Topical Application: An In Vitro And In Vivo Study, Renee T. Carter, Sean Swetledge, Sara Navarro, Chin C. Liu, Nikole Ineck, Andrew C. Lewin, Fabrizio Donnarumma, Ede Bodoki, Rhett W. Stout, Carlos Astete, Jangwook P. Jung, Cristina M. Sabliov
Faculty Publications
Antioxidant therapies are of interest in the prevention and management of ocular disorders such as cataracts. Although an active area of interest, topical therapy with antioxidants for the treatment of cataracts is complicated by multiple ocular anatomical barriers, product stability, and solubility. Entrapment and delivery of antioxidants with poly(lactic-co-glycolic acid) nanoparticles is a possible solution to these challenges, however, little is known regarding their effects in vitro or in vivo. Our first aim was to investigate the impact of blank and lutein loaded PLGA nanoparticles on viability and development of reactive oxygen species in lens epithelial cells in vitro. Photo-oxidative …
Ion-Mediated Structural Discontinuities In Phospholipid Vesicles, Judith U. De Mel, Stefanie Klisch, Sudipta Gupta, Gerald J. Schneider
Ion-Mediated Structural Discontinuities In Phospholipid Vesicles, Judith U. De Mel, Stefanie Klisch, Sudipta Gupta, Gerald J. Schneider
Faculty Publications
Despite intense research, methods for controlling soft matter’s spontaneous self-assembly into well-defined layers remain a significant challenge. We observed ion-induced structural discontinuities of phospholipid vesicles that can be exploited for controlled self-assembly of soft materials, using DOPC and NaCl as a model system. The observations were made for the 0.25 wt % lipid concentration. We used dynamic light scattering, zeta-potential measurement, cryo-electron microscopy, small-angle X-ray, and small-angle neutron scattering to understand the reason for the discontinuities. For salt concentrations below 8 mM, we observed a decrease in the liposome diameter with increased NaCl concentration. Above 8 mM, we measured a …
The Role Of Biological Plasticity In Model-Based Translational Research, Jessica A. Bolker
The Role Of Biological Plasticity In Model-Based Translational Research, Jessica A. Bolker
Faculty Publications
Reports of low replicability and translatability of biomedical research have called the value of animal models into question. The problems are real, but abandoning animal research is not the solution. Rather, improving the translatability of model-based research requires attention to relevant differences between humans and models, and to attributes of the models themselves that are essential to both robust science and effective translation. One is biological plasticity, the responsiveness of individual organisms to complex and variable environments. Though under-represented in model systems (for both historical and practical reasons), plasticity is central to human biology. While there are good reasons to …
A Model-Based Reverse System Engineering Methodology For Analyzing Complex Biological Systems With A Case Study In Glycolysis, Gerald L. Fudge, Emily Brown Reeves
A Model-Based Reverse System Engineering Methodology For Analyzing Complex Biological Systems With A Case Study In Glycolysis, Gerald L. Fudge, Emily Brown Reeves
Faculty Publications
We propose a model-based reverse systems engineering (MBRSE) methodology for biological systems that relies on requirements analysis in conjunction with model-based systems engineering (MBSE). The goal of this methodology is to better understand complex multiscale biological systems, discover knowledge gaps, and make testable predictions. The similarities between human-engineered and biological systems motivate this approach. Furthermore, traditional reductionist paradigms in biology have proven insufficient for understanding and accurately predicting complex biological systems, as opposed to systems engineering approaches that have proven effective in supporting the design and analysis of complex engineered systems spanning multiple spatiotemporal scales. We employ our MBRSE methodology …
Teaching Fairness In Preschool: Evaluating The Steps In An Anti-Bias Education, Sharon Carnahan, Courtney Trohn, Cora Burkley, Diane Terorde Doyle
Teaching Fairness In Preschool: Evaluating The Steps In An Anti-Bias Education, Sharon Carnahan, Courtney Trohn, Cora Burkley, Diane Terorde Doyle
Faculty Publications
How do young children learn how to talk about ethical concepts, such as fairness and equity? The current research assesses the effects of philosophy-based anti-bias lessons aimed at three to five -year-olds in a laboratory preschool and explores the relationship between socioemotional skills, language development, and understanding of ethical concepts. The constructivist curriculum was grounded in storybook lessons with corresponding activities. In a pre-post test design, we interviewed children before and after lessons in fairness education that included book reading, related games, and philosophical discussions. We found that children showed a significant increase in comprehension of equity related terms and …
Love Of Creation: Exploring Diversity And Commonality Among Religious And Philosophical Traditions, Tim Lomas, Brendan W. Case, Matthew T. Lee, Jayanti Basu, Lindsie Bear, Richard G. Cowden, Yudit Kornberg Greenberg, Tayyab Rashid, Tyler J. Vanderweele
Love Of Creation: Exploring Diversity And Commonality Among Religious And Philosophical Traditions, Tim Lomas, Brendan W. Case, Matthew T. Lee, Jayanti Basu, Lindsie Bear, Richard G. Cowden, Yudit Kornberg Greenberg, Tayyab Rashid, Tyler J. Vanderweele
Faculty Publications
Love is widely recognized as one of the most important, desired, and consequential aspects of the human condition, and thus has rightly been the focus of much academic attention. However, this interest has tended to concentrate on specific forms of love—especially romantic and familial forms—to the exclusion of others. One such overlooked form is love of “creation”—of the world and the wider cosmos in which human beings find themselves. Throughout history and across cultures, this kind of love has been developed and articulated by religious and philosophical traditions in diverse ways. This article showcases a selection of ten such traditions, …