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Temporal Trends In Cardiovascular Hospital Discharges Following A Mass Chlorine Exposure Event In Graniteville, South Carolina, Ashley V. Howell, John E. Vena, Bo Cai, Daniel T. Lackland, Lucy Ingram, Andrew B. Lawson, Erik R. Svendsen May 2019

Temporal Trends In Cardiovascular Hospital Discharges Following A Mass Chlorine Exposure Event In Graniteville, South Carolina, Ashley V. Howell, John E. Vena, Bo Cai, Daniel T. Lackland, Lucy Ingram, Andrew B. Lawson, Erik R. Svendsen

Faculty Publications

Background: On January 6, 2005, a train derailed in Graniteville, South Carolina, releasing nearly 60,000 kg of toxic chlorine gas. The disaster left nine people dead and was responsible for hundreds of hospitalizations and outpatient visits in the subsequent weeks. While chlorine gas primarily affects the respiratory tract, a growing body of evidence suggests that acute exposure may also cause vascular injury and cardiac toxicity. Here, we describe the incidence of cardiovascular hospitalizations among residents of the zip codes most affected by the chlorine gas plume, and compare the incidence of cardiovascular discharges in the years leading up to the …


In Silico Identification Of Genetic Mutations Conferring Resistance To Acetohydroxyacid Synthase Inhibitors: A Case Study Of Kochia Scoparia, Yan Li, Michael D. Netherland, Chaoyang Zhang, Huixiao Hong, Ping Gong May 2019

In Silico Identification Of Genetic Mutations Conferring Resistance To Acetohydroxyacid Synthase Inhibitors: A Case Study Of Kochia Scoparia, Yan Li, Michael D. Netherland, Chaoyang Zhang, Huixiao Hong, Ping Gong

Faculty Publications

Mutations that confer herbicide resistance are a primary concern for herbicide-based chemical control of invasive plants and are often under-characterized structurally and functionally. As the outcome of selection pressure, resistance mutations usually result from repeated long-term applications of herbicides with the same mode of action and are discovered through extensive field trials. Here we used acetohydroxyacid synthase (AHAS) of Kochia scoparia (KsAHAS) as an example to demonstrate that, given the sequence of a target protein, the impact of genetic mutations on ligand binding could be evaluated and resistance mutations could be identified using a biophysics-based computational approach. Briefly, …


Longitudinal Homogenization Of The Microbiome Between Both Occupants And The Built Environment In A Cohort Of United States Air Force Cadets, Anukriti Sharma, Miles Richardson, Lauren Cralle, Christopher E. Stamper, Juan P. Maestre, Kelly A. Stearns-Yoder, Teodor T. Postolache, Katherine L. Bates, Kerry A. Kinney, Lisa A. Brenner, Christopher A. Lowry, Jack A. Gilbert, Andrew J. Hoisington May 2019

Longitudinal Homogenization Of The Microbiome Between Both Occupants And The Built Environment In A Cohort Of United States Air Force Cadets, Anukriti Sharma, Miles Richardson, Lauren Cralle, Christopher E. Stamper, Juan P. Maestre, Kelly A. Stearns-Yoder, Teodor T. Postolache, Katherine L. Bates, Kerry A. Kinney, Lisa A. Brenner, Christopher A. Lowry, Jack A. Gilbert, Andrew J. Hoisington

Faculty Publications

The microbiome of the built environment has important implications for human health and wellbeing; however, bidirectional exchange of microbes between occupants and surfaces can be confounded by lifestyle, architecture, and external environmental exposures. Here, we present a longitudinal study of United States Air Force Academy cadets (n = 34), which have substantial homogeneity in lifestyle, diet, and age, all factors that influence the human microbiome. We characterized bacterial communities associated with (1) skin and gut samples from roommate pairs, (2) four built environment sample locations inside the pairs’ dormitory rooms, (3) four built environment sample locations within shared spaces …


Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation And Persistent Tactile Sensitivity In Mouse Model Of Allergen-Provoked Localized Vulvodynia, Beebie Boo, Rohit Kamath, Erica Arriaga-Gomez, Jasmine Landry, Elizabeth Emanuel, Sookyong Joo, Marietta Sald Montivero, Tijana Martinov, Brian T. Fife, Devavani Chatterjea May 2019

Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation And Persistent Tactile Sensitivity In Mouse Model Of Allergen-Provoked Localized Vulvodynia, Beebie Boo, Rohit Kamath, Erica Arriaga-Gomez, Jasmine Landry, Elizabeth Emanuel, Sookyong Joo, Marietta Sald Montivero, Tijana Martinov, Brian T. Fife, Devavani Chatterjea

Faculty Publications

Vulvodynia is a remarkably prevalent chronic pain condition of unknown etiology. An increase in numbers of vulvar mast cells often accompanies a clinical diagnosis of vulvodynia and a history of allergies amplifies the risk of developing this condition. We previously showed that repeated exposures to oxazolone dissolved in ethanol on the labiar skin of mice led to persistent genital sensitivity to pressure and a sustained increase in labiar mast cells. Here we sensitized female mice to the hapten dinitrofluorobenzene (DNFB) dissolved in saline on their flanks, and subsequently challenged them with the same hapten or saline vehicle alone for ten …


An Ensemble Of Lipoxygenase Structures Reveals Novel Conformations Of The Fe Coordination Sphere, Svetlana Pakhomova, William E. Boeglin, David B. Neau, Sue G. Bartlett, Alan R. Brash, Marcia E. Newcomer May 2019

An Ensemble Of Lipoxygenase Structures Reveals Novel Conformations Of The Fe Coordination Sphere, Svetlana Pakhomova, William E. Boeglin, David B. Neau, Sue G. Bartlett, Alan R. Brash, Marcia E. Newcomer

Faculty Publications

© 2019 The Protein Society The regio- and stereo-specific oxygenation of polyunsaturated fatty acids is catalyzed by lipoxygenases (LOX); both Fe and Mn forms of the enzyme have been described. Structural elements of the Fe and Mn coordination spheres and the helical catalytic domain in which the metal center resides are highly conserved. However, animal, plant, and microbial LOX each have distinct features. We report five crystal structures of a LOX from the fungal plant pathogen Fusarium graminearum. This LOX displays a novel amino terminal extension that provides a wrapping domain for dimerization. Moreover, this extension appears to interfere with …


Access Before Evidence And The Price Of The Fda's New Drug Authorities, Erika Lietzan May 2019

Access Before Evidence And The Price Of The Fda's New Drug Authorities, Erika Lietzan

Faculty Publications

Sometimes drug innovation seems to happen in reverse. Patients enjoy a treatment for years even though the treatment has not been approved by the FDA or proven safe and effective to the FDA's standards. (Sometimes this happens because the FDA has declined to take enforcement action.) The agency encourages companies to perform the work necessary to satisfy the United States "gold standard" for new drug approval, however, by promising exclusivity in the marketplace. When a company does this work, at considerable expense, the results are predictable. The new drug is expensive, and patients and payers (and sometimes policymakers) are outraged. …


A Gradient Of Pollination Specialization In Three Species Of Bolivian Centropogon, Laura P. Lagomarsino, Nathan Muchhala May 2019

A Gradient Of Pollination Specialization In Three Species Of Bolivian Centropogon, Laura P. Lagomarsino, Nathan Muchhala

Faculty Publications

© 2019 Botanical Society of America Premise: Closely related plant species with overlapping ranges often experience competition for pollination services. Such competition can select for divergence in floral traits that attract pollinators or determine pollen placement. While most species in Centropogon (Campanulaceae: Lobelioideae) have flowers that suggest adaptation to bat or hummingbird pollination, actual pollinators are rarely documented, and a few species have a mix of traits from both pollination syndromes. We studied the pollination biology of a “mixed-syndrome” species and its co-occurring congeners to examine the relationship between floral traits and visitation patterns for Centropogon. Methods: Fieldwork at two …


The Effects Of Ambient Temperature And Lighting Intensity On Wheel-Running Behavior In A Diurnal Rodent, The Nile Grass Rat (Arvicanthis Niloticus), Garrett M. Fogo, Alyssa M. Goodwin, Ohanes S. Khacherian, Brandi J. Ledbetter, Andrew J. Gall May 2019

The Effects Of Ambient Temperature And Lighting Intensity On Wheel-Running Behavior In A Diurnal Rodent, The Nile Grass Rat (Arvicanthis Niloticus), Garrett M. Fogo, Alyssa M. Goodwin, Ohanes S. Khacherian, Brandi J. Ledbetter, Andrew J. Gall

Faculty Publications

Environmental conditions, such as the light-dark cycle and temperature, affect the display of circadian rhythmicity and locomotor activity patterns in mammals. Here, we tested the hypothesis that manipulating these environmental conditions would affect wheel-running activity patterns in a diurnal rodent, the Nile grass rat (Arvicanthis niloticus). Grass rats are diurnal in the field, however, a subset switch from a day-active pattern to a night-active pattern of activity after the introduction of a running wheel. The mechanism of this chronotype switch remains largely unknown. In the present study, grass rats were presented with running wheels in 12:12 light-dark conditions. First, subjects …


Autographic And Allographic Imitation: Revisiting Counterfeit In Linguistic And Musical Arts, Jeremy Orosz Apr 2019

Autographic And Allographic Imitation: Revisiting Counterfeit In Linguistic And Musical Arts, Jeremy Orosz

Faculty Publications

Imitation within sonic arts, linguistic, musical, or otherwise, broadly defined, is a heterogeneous set of practices ranging from comical impersonation to outright counterfeit or forgery. This paper provides a taxonomy of imitation and mimicry within both language and music, dividing each into two respective categories, autographic imitation and allographic imitation, the terms for which are repurposed from Nelson Goodman’s Languages of Art.


Siah2 Modulates Sex-Dependent Metabolic And Inflammatory Responses In Adipose Tissue To A High-Fat Diet Challenge, Sujoy Ghosh, Jessica L. Taylor, Tamra M. Mendoza, Thanh Dang, David H. Burk, Yongmei Yu, Gail Kilroy, Z. Elizabeth Floyd Apr 2019

Siah2 Modulates Sex-Dependent Metabolic And Inflammatory Responses In Adipose Tissue To A High-Fat Diet Challenge, Sujoy Ghosh, Jessica L. Taylor, Tamra M. Mendoza, Thanh Dang, David H. Burk, Yongmei Yu, Gail Kilroy, Z. Elizabeth Floyd

Faculty Publications

© 2019 The Author(s). Background: The obesity-related risk of developing metabolic syndrome is higher in males than in females of reproductive age, likely due to estrogen-mediated reduced adipose tissue inflammation and fibrosis with hypertrophied adipocytes. Depletion of the ubiquitin ligase Siah2 reduced white adipose tissue inflammation and improved glucose metabolism in obese male mice. Siah2 is a transcriptional target of estrogen, but data is lacking about the effect of Siah2 on adipose tissue of females. We therefore evaluated the impact of Siah2 deficiency on white and brown adipose tissue in females of reproductive age. Methods: Body composition, adipose tissue morphology, …


Synthesis, Characterization, And Evaluation Of Near-Ir Boron Dipyrromethene Bioconjugates For Labeling Of Adenocarcinomas By Selectively Targeting The Epidermal Growth Factor Receptor, Nichole E.M. Kaufman, Qianli Meng, Kaitlin E. Griffin, Sitanshu S. Singh, Achyut Dahal, Zehua Zhou, Frank R. Fronczek, J. Michael Mathis, Seetharama D. Jois, M. Graça H. Vicente Apr 2019

Synthesis, Characterization, And Evaluation Of Near-Ir Boron Dipyrromethene Bioconjugates For Labeling Of Adenocarcinomas By Selectively Targeting The Epidermal Growth Factor Receptor, Nichole E.M. Kaufman, Qianli Meng, Kaitlin E. Griffin, Sitanshu S. Singh, Achyut Dahal, Zehua Zhou, Frank R. Fronczek, J. Michael Mathis, Seetharama D. Jois, M. Graça H. Vicente

Faculty Publications

Copyright © 2019 American Chemical Society. A series of five boron dipyrromethene (BODIPY) bioconjugates containing an epidermal growth factor receptor (EGFR)-targeted pegylated LARLLT peptide and/or a glucose or biotin ethylene diamine group were synthesized, and the binding capability of the new conjugates to the extracellular domain of EGFR was investigated using molecular modeling, surface plasmon resonance, fluorescence microscopy, competitive binding assays, and animal studies. The BODIPY conjugates with a LARLLT peptide were found to bind specifically to EGFR, whereas those lacking the peptide bound weakly and nonspecifically. All BODIPY conjugates showed low cytotoxicity (IC50 > 94 μM) in HT-29 cells, both …


Ecological Mechanisms Can Modify Radiation Effects In A Key Forest Mammal Of Chernobyl, Tapio Mappes, Zbyszek Boratynski, Kati Kivisaari, Anton Lavrinienko, Anders P. Moller, Eugene Tukalenko, Phillip C. Watts Apr 2019

Ecological Mechanisms Can Modify Radiation Effects In A Key Forest Mammal Of Chernobyl, Tapio Mappes, Zbyszek Boratynski, Kati Kivisaari, Anton Lavrinienko, Anders P. Moller, Eugene Tukalenko, Phillip C. Watts

Faculty Publications

Nuclear accidents underpin the need to quantify the ecological mechanisms which determineinjury to ecosystems from chronic low-dose radiation. Here, we tested the hypothesis that ecological mech-anisms interact with ionizing radiation to affect natural populations in unexpected ways. We used large-scale replicated experiments and food manipulations in wild populations of the rodent, Myodes glareolus,inhabiting the region near the site of the Chernobyl disaster of 1986. We show linear decreases in breedingsuccess with increasing ambient radiation levels with no evidence of any threshold below which effects arenot seen. Food supplementation of experimental populations resulted in increased abundances but only inlocations where radioactive …


Mycoprotein: The Future Of Nutritious Nonmeat Protein, A Symposium Review, Tim Finnigan, Benjamin Wall, Peter Wilde, Francis Stephens, Steve Taylor, Marjorie Freedman Apr 2019

Mycoprotein: The Future Of Nutritious Nonmeat Protein, A Symposium Review, Tim Finnigan, Benjamin Wall, Peter Wilde, Francis Stephens, Steve Taylor, Marjorie Freedman

Faculty Publications

Mycoprotein is an alternative, nutritious protein source with a meat-like texture made from Fusarium venenatum, a naturally occurring fungus. Its unique method of production yields a significantly reduced carbon and water footprint relative to beef and chicken. Mycoprotein, sold as Quorn, is consumed in 17 countries, including the United States. In line with current dietary guidelines, mycoprotein is high in protein and fiber, and low in fat, cholesterol, sodium, and sugar. Mycoprotein may help maintain healthy blood cholesterol levels, promote muscle synthesis, control glucose and insulin levels, and increase satiety. It is possible that some susceptible consumers will become …


In Situ Observations Of Fish Larvae Encased Within A Pelagic Gelatinous Matrix, Adam T. Greer, Luciano M. Chiaverano, James G. Ditty, Frank J. Hernandez Apr 2019

In Situ Observations Of Fish Larvae Encased Within A Pelagic Gelatinous Matrix, Adam T. Greer, Luciano M. Chiaverano, James G. Ditty, Frank J. Hernandez

Faculty Publications

The degree to which marine fish larvae aggregate (i.e. patchiness) is predominantly determined by the physical oceanographic environment. Biological traits, however, can also influence spatial distributions and have adaptive value for larvae (e.g. favorable transport or reducing predation mortality). Although several fish families are known to release eggs within a gelatinous matrix, hatched larvae have not been found inside this type of structure. We present observations of hatched, preflexion yolk-sac larvae encased within a pelagic gelatinous matrix (mass). Two different masses (40-60 mm in length) containing free swimming, elongate larvae were imaged in the northern Gulf of Mexico (nGOM) near …


Linking Water Quality To Aedes Aegypti And Zika In Flood-Prone Neighborhoods, Rebeca De Jesus Crespo Apr 2019

Linking Water Quality To Aedes Aegypti And Zika In Flood-Prone Neighborhoods, Rebeca De Jesus Crespo

Faculty Publications

No abstract provided.


Plasticity, Technicity, Writing, Deborah Goldgaber Apr 2019

Plasticity, Technicity, Writing, Deborah Goldgaber

Faculty Publications

No abstract provided.


Intraspecific Variation In A Dominant Prey Species Can Bias Marine Predator Dietary Estimates Derived From Stable Isotope Analysis, Michael J. Polito, Wayne Z. Trivelpiece, Christian S. Reiss, Susan G. Trivelpiece, Jefferson T. Hinke, William P. Patterson, Steven D. Emslie Apr 2019

Intraspecific Variation In A Dominant Prey Species Can Bias Marine Predator Dietary Estimates Derived From Stable Isotope Analysis, Michael J. Polito, Wayne Z. Trivelpiece, Christian S. Reiss, Susan G. Trivelpiece, Jefferson T. Hinke, William P. Patterson, Steven D. Emslie

Faculty Publications

No abstract provided.


Rapid Plant Diversification In The Andes Does Not Require Flowers, Laura P. Lagomarsino Apr 2019

Rapid Plant Diversification In The Andes Does Not Require Flowers, Laura P. Lagomarsino

Faculty Publications

No abstract provided.


Amplification Dynamics Of Platy-1 Retrotransposons In The Cebidae Platyrrhine Lineage, Jessica M. Storer, Jackson R. Mierl, Sarah A. Brantley, Breanna Threeton, Yahor Sukharutski, Lydia C. Rewerts, Corey P. St Romain, Madeline M. Foreman, Jasmine N. Baker, Jerilyn A. Walker, Joseph D. Orkin, Amanda D. Melin, Kimberley A. Phillips, Miriam K. Konkel, Mark A. Batzer Apr 2019

Amplification Dynamics Of Platy-1 Retrotransposons In The Cebidae Platyrrhine Lineage, Jessica M. Storer, Jackson R. Mierl, Sarah A. Brantley, Breanna Threeton, Yahor Sukharutski, Lydia C. Rewerts, Corey P. St Romain, Madeline M. Foreman, Jasmine N. Baker, Jerilyn A. Walker, Joseph D. Orkin, Amanda D. Melin, Kimberley A. Phillips, Miriam K. Konkel, Mark A. Batzer

Faculty Publications

© 2019 The Author(s). Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. Platy-1 elements are Platyrrhine-specific, short interspersed elements originally discovered in the Callithrix jacchus (common marmoset) genome. To date,only themarmoset genomehas been analyzed for Platy-1 repeat content.Here,we report full-length Platy-1 insertions in other NewWorld monkey (NWM) genomes (Saimiri boliviensis, squirrel monkey; Cebus imitator, capuchin monkey; and Aotus nancymaae, owl monkey) and analyze the amplification dynamics of lineage-specific Platy-1 insertions. A relatively small number of full-length and lineage-specific Platy-1 elements were found in the squirrel, capuchin, and owl monkey genomes compared with the …


Influence Of Sorghum Cultivar, Phenological Stage, And Fertilization On Development And Reproduction Of Melanaphis Sacchari (Hemiptera: Aphididae), Blake E. Wilson, Jeffrey Davis, Thomas Reagan, Luna Lama Apr 2019

Influence Of Sorghum Cultivar, Phenological Stage, And Fertilization On Development And Reproduction Of Melanaphis Sacchari (Hemiptera: Aphididae), Blake E. Wilson, Jeffrey Davis, Thomas Reagan, Luna Lama

Faculty Publications

The sugarcane aphid, Melanaphis sacchari (Zehntner) (Hemiptera: Aphididae), is an invasive pest of grain sorghum, Sorghum bicolor (L) Moench (Poaceae). Since its first outbreak in sorghum in 2013, severe infestations have spread throughout the southern USA, causing major economic losses. Whereas insecticide applications can mitigate some of the pest's impacts, a sustainable ecology-based management program is needed to reduce reliance on chemical control. Two greenhouse assays examined the influence of selected host plant characteristics on M. sacchari life table parameters. We studied the effects of silicon (rates equivalent to 0 and 3,360 kg silicon per ha) and nitrogen (rates equivalent …


Fifty Shades Of Brown: Macroevolution Of Plumage Brightness In The Furnariida, A Large Clade Of Drab Neotropical Passerines, Rafael S. Marcondes, Robb T. Brumfield Apr 2019

Fifty Shades Of Brown: Macroevolution Of Plumage Brightness In The Furnariida, A Large Clade Of Drab Neotropical Passerines, Rafael S. Marcondes, Robb T. Brumfield

Faculty Publications

© 2019 The Author(s). Evolution © 2019 The Society for the Study of Evolution. Both natural and sexual selection are thought to affect the evolution of bird color. Most studies of the topic have focused on sexually dichromatic taxa and showy plumages, which are expected to be more influenced by social selection and usually result in increased conspicuousness. However, many bird clades display dull brown or gray plumages that vary greatly in brightness (lightness), but little in hue (shade). Here, we examine the macroevolution of brightness in one such clade, the Furnariida. We make comparisons across light environments, body parts, …


Age And Growth Of Gray Triggerfish (Balistes Capriscus) From A North-Central Gulf Of Mexico Artifical Reef Zone, Amanda E. Jefferson, Robert J. Allman, Ashley E. Pacicco, James S. Franks, Frank J. Hernandez, Mark A. Albins, Sean P. Powers, Robert L. Shipp, J. Marcus Drymon Apr 2019

Age And Growth Of Gray Triggerfish (Balistes Capriscus) From A North-Central Gulf Of Mexico Artifical Reef Zone, Amanda E. Jefferson, Robert J. Allman, Ashley E. Pacicco, James S. Franks, Frank J. Hernandez, Mark A. Albins, Sean P. Powers, Robert L. Shipp, J. Marcus Drymon

Faculty Publications

The overexploitation of many traditionally targeted reef fishes such as red snapper (Lutjanus campechanus, Poey 1860), alongside the implementation of increasingly restrictive management measures on those species, has led to increased targeting of conventionally discarded Gulf of Mexico gray triggerfish (Balistes capriscus, Gmelin 1789) commercially and recreationally. The goal of this study was to assess age and growth of gray triggerfish from the Alabama Artificial Reef Zone in the north-central Gulf of Mexico. Gray triggerfish (n = 1135) were collected predominantly from artificial habitat during 1999 – 2017. Specimens were sexed macroscopically and ages were assigned …


Proximal Tubular Cell–Specific Ablation Of Carnitine Acetyltransferase Causes Tubular Disease And Secondary Glomerulosclerosis, Claudia Kruger, Trang Tiffany Nguyen, Chelsea Breaux, Alana Guillory, Margaret Mangelli, Kevin T. Fridianto, Jean Paul Kovalik, David H. Burk, Robert C. Noland, Randall Mynatt, Krisztian Stadler Apr 2019

Proximal Tubular Cell–Specific Ablation Of Carnitine Acetyltransferase Causes Tubular Disease And Secondary Glomerulosclerosis, Claudia Kruger, Trang Tiffany Nguyen, Chelsea Breaux, Alana Guillory, Margaret Mangelli, Kevin T. Fridianto, Jean Paul Kovalik, David H. Burk, Robert C. Noland, Randall Mynatt, Krisztian Stadler

Faculty Publications

© 2019 by the American Diabetes Association. Proximal tubular epithelial cells are highly energy demanding. Their energy need is covered mostly from mitochondrial fatty acid oxidation. Whether derailments in fatty acid metabolism and mitochondrial dysfunction are forerunners of tubular damage has been suggested but is not entirely clear. Here we modeled mitochondrial overload by creating mice lacking the enzyme carnitine acetyltransferase (CrAT) in the proximal tubules, thus limiting a primary mechanism to export carbons under conditions of substrate excess. Mice developed tubular disease and, interestingly, secondary glomerulosclerosis. This was accompanied by increased levels of apoptosis regulator and fibrosis markers, increased …


Amplification Dynamics Of Platy-1 Retrotransposons In The Cebidae Platyrrhine Lineage, Mark A. Batzer, Jessica M. Storer, Jackson R. Mierl, Sarah A. Brantley Apr 2019

Amplification Dynamics Of Platy-1 Retrotransposons In The Cebidae Platyrrhine Lineage, Mark A. Batzer, Jessica M. Storer, Jackson R. Mierl, Sarah A. Brantley

Faculty Publications

Platy-1 elements are Platyrrhine-specific, short interspersed elements originally discovered in the Callithrix jacchus (common marmoset) genome. To date, only the marmoset genome has been analyzed for Platy-1 repeat content. Here, we report full-length Platy-1 insertions in other New World monkey (NWM) genomes (Saimiri boliviensis, squirrel monkey; Cebus imitator, capuchin monkey; and Aotus nancymaae, owl monkey) and analyze the amplification dynamics of lineage-specific Platy-1 insertions. A relatively small number of full-length and lineage-specific Platy-1 elements were found in the squirrel, capuchin, and owl monkey genomes compared with the marmoset genome. In addition, only a few older Platy-1 subfamilies were recovered in …


Differentiation Of Surface Water And Groundwater In A Karst System Using Anthropogenic Signatures, Joe Honings Apr 2019

Differentiation Of Surface Water And Groundwater In A Karst System Using Anthropogenic Signatures, Joe Honings

Faculty Publications

Surface water-groundwater interaction within a karstic system enhances contaminant transport, making karst aquifers susceptible to anthropogenic practices. Contaminated waters related to agricultural and animal husbandry in northwestern Illinois (USA) prompted this investigation. Six streams and five springs were sampled for 16 parameters to assess anthropogenic influences. Statistical analyses revealed differences in 13 of 16 parameters between the stream and spring waters. Rock-water interaction was identified as the dominant mechanism defining the chemistry for both waters, which were classified as Ca-Mg HCO3. Elevated nitrate as nitrogen (NO3-N), chloride (Cl-), sodium, and potassium concentrations indicate that human activities have influenced the quality …


Virulence-Driven Trade-Offs In Disease Transmission: A Meta-Analysis*, Miguel A. Acevedo, Forrest P. Dillemuth, Andrew J. Flick, Matthew J. Faldyn, Bret D. Elderd Apr 2019

Virulence-Driven Trade-Offs In Disease Transmission: A Meta-Analysis*, Miguel A. Acevedo, Forrest P. Dillemuth, Andrew J. Flick, Matthew J. Faldyn, Bret D. Elderd

Faculty Publications

© 2019 The Author(s). Evolution © 2019 The Society for the Study of Evolution. The virulence–transmission trade-off hypothesis proposed more than 30 years ago is the cornerstone in the study of host–parasite co-evolution. This hypothesis rests on the premise that virulence is an unavoidable and increasing cost because the parasite uses host resources to replicate. This cost associated with replication ultimately results in a deceleration in transmission rate because increasing within-host replication increases host mortality. Empirical tests of predictions of the hypothesis have found mixed support, which cast doubt about its overall generalizability. To quantitatively address this issue, we conducted …


Retrieval-Based Word Learning In Young Typically Developing Children And Children With Developmental Language Disorder I: The Benefits Of Repeated Retrieval, Laurence B. Leonard, Jeffrey Karpicke, Patricia Deevy, Christine Weber, Sharon Christ, Eileen Haebig, Sofía Souto, Justin B. Kueser, Windi Krok Apr 2019

Retrieval-Based Word Learning In Young Typically Developing Children And Children With Developmental Language Disorder I: The Benefits Of Repeated Retrieval, Laurence B. Leonard, Jeffrey Karpicke, Patricia Deevy, Christine Weber, Sharon Christ, Eileen Haebig, Sofía Souto, Justin B. Kueser, Windi Krok

Faculty Publications

Purpose: Scholars have long noted that retention improves significantly when learners frequently test themselves on the new material rather than engage in continuous study with no intermittent testing. In this study, we apply the notion of repeated testing or retrieval to the process of word learning in preschool-age children with and without developmental language disorder (DLD). Method: Novel words and their meanings were taught to 10 children with DLD and 10 typically developing (TD) children matched on age (DLD, M = 63.4 months; TD, M = 63.2 months). Recall was assessed immediately after the 2nd learning session and then again …


Retrieval-Based Word Learning In Young Typically Developing Children And Children With Development Language Disorder Ii: A Comparison Of Retrieval Schedules, Eileen Haebig, Laurence B. Leonard, Patricia Deevy, Jeffrey Karpicke, Sharon L. Christ, Evan Usler, Justin B. Kueser, Sofía Souto, Windi Krok, Christine Weber Apr 2019

Retrieval-Based Word Learning In Young Typically Developing Children And Children With Development Language Disorder Ii: A Comparison Of Retrieval Schedules, Eileen Haebig, Laurence B. Leonard, Patricia Deevy, Jeffrey Karpicke, Sharon L. Christ, Evan Usler, Justin B. Kueser, Sofía Souto, Windi Krok, Christine Weber

Faculty Publications

Purpose: Retrieval practice has been found to be a powerful strategy to enhance long-term retention of new information; however, the utility of retrieval practice when teaching young children new words is largely unknown, and even less is known for young children with language impairments. The current study examined the effect of 2 different retrieval schedules on word learning at both the behavioral and neural levels. Method: Participants included 16 typically developing children (MTD = 61.58 months) and 16 children with developmental language disorder (MDLD = 59.60 months). Children participated in novel word learning sessions in which the spacing of retrieval …


Letter To The Editor: A Response To Selvaraj And Boisclair (2019), S. Leane, M. M. Herlihy, F. Curran, J. Kenneally, N. Forde, C. A. Simintiras, R. G. Sturmey, P. Lonergan, S. T. Butler Apr 2019

Letter To The Editor: A Response To Selvaraj And Boisclair (2019), S. Leane, M. M. Herlihy, F. Curran, J. Kenneally, N. Forde, C. A. Simintiras, R. G. Sturmey, P. Lonergan, S. T. Butler

Faculty Publications

No abstract provided.


The Strength Of Migratory Connectivity For Birds En Route To Breeding Through The Gulf Of Mexico, Emily B. Cohen, Clark R. Rushing, Frank R. Moore, Michael T. Hallworth, Jeffrey A. Hostetler, Mariamar Gutierrez Ramirez, Peter P. Marra Apr 2019

The Strength Of Migratory Connectivity For Birds En Route To Breeding Through The Gulf Of Mexico, Emily B. Cohen, Clark R. Rushing, Frank R. Moore, Michael T. Hallworth, Jeffrey A. Hostetler, Mariamar Gutierrez Ramirez, Peter P. Marra

Faculty Publications

The strength of migratory connectivity is a measure of the cohesion of populations among phases of the annual cycle, including breeding, migration, and wintering. Many Nearctic‐Neotropical species have strong migratory connectivity between breeding and wintering phases of the annual cycle. It is less clear if this strength persists during migration when multiple endogenous and exogenous factors may decrease the cohesion of populations among routes or through time along the same routes. We sampled three bird species, American redstart Setophaga ruticilla, ovenbird Seiurus aurocapilla, and wood thrush Hylocichla mustelina, during spring migration through the Gulf of Mexico region …