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Articles 6541 - 6570 of 35619
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Formation, Organization, And Synaptic Properties Of Circuits Between Thalamic Reticular Nucleus And Dorsal Lateral Geniculate Nucleus., Peter W. Campbell
Formation, Organization, And Synaptic Properties Of Circuits Between Thalamic Reticular Nucleus And Dorsal Lateral Geniculate Nucleus., Peter W. Campbell
Electronic Theses and Dissertations
The thalamic reticular nucleus (TRN) is an interface between thalamus and cortex that regulates thalamocortical rhythms and modulates sensory processing. Thalamocortical axon collaterals provide feedforward excitatory input onto GABAergic TRN neurons, which in turn convey feedback inhibition to dorsal thalamus. Here we used the mouse visual system to study the organization, pattern of innervation and functional responses between TRN and the dorsal lateral geniculate nucleus (dLGN). We used genetically modified mice to target components of this feedback loop (feedforward: CRH-Cre; feedback: GAD65 or SST-Cre) and we created Math 5-/- strains to examine the impact of visual deaffrentation in these …
Short-Term Financial Confidence As A Predictor Of Academic Achievement And Six-Year Graduation Success Of First-Year Students., Shawna M. Clark
Short-Term Financial Confidence As A Predictor Of Academic Achievement And Six-Year Graduation Success Of First-Year Students., Shawna M. Clark
Electronic Theses and Dissertations
This dissertation explores the relationships among short-term financial confidence, academic achievement, six-year graduation success, and pre-college demographic characteristics for first-time, full-time, traditionally aged first-year students. The sample population was from a mid-sized Midwestern four-year degree granting university. These students were enrolled for the first time in Fall 2013 and participated in the survey used for data collection during that term. Examining the role of socioeconomic status and its relationship with short-term financial confidence was first addressed to provide a context for the other research questions. From this, the research question examined the predictive nature of pre-college demographic characteristics on short-term …
Computational Techniques In Medical Image Analysis Application For White Blood Cells Classification., Omar Dekhil
Computational Techniques In Medical Image Analysis Application For White Blood Cells Classification., Omar Dekhil
Electronic Theses and Dissertations
White blood cells play important rule in the human body immunity and any change in their count may cause serious diseases. In this study, a system is introduced for white blood cells localization and classification. The dataset used in this study is formed by two components, the first is the annotation dataset that will be used in the localization (364 images), and the second is labeled classes that will be used in the classification (12,444 images). For the localization, two approaches will be discussed, a classical approach and a deep learning based approach. For the classification, 5 different deep learning …
Novel Bayesian Methodology For The Analysis Of Single-Cell Rna Sequencing Data., Michael Sekula
Novel Bayesian Methodology For The Analysis Of Single-Cell Rna Sequencing Data., Michael Sekula
Electronic Theses and Dissertations
With single-cell RNA sequencing (scRNA-seq) technology, researchers are able to gain a better understanding of health and disease through the analysis of gene expression data at the cellular-level; however, scRNA-seq data tend to have high proportions of zero values, increased cell-to-cell variability, and overdispersion due to abnormally large expression counts, which create new statistical problems that need to be addressed. This dissertation includes three research projects that propose Bayesian methodology suitable for scRNA-seq analysis. In the first project, a hurdle model for identifying differentially expressed genes across cell types in scRNA-seq data is presented. This model incorporates a correlated random …
Influences Of Material Extrusion Additive Manufacturing (Meam) Parameters And Additives On Polyvinylidene Fluoride (Pvdf) Properties., Niknam Momenzadeh
Influences Of Material Extrusion Additive Manufacturing (Meam) Parameters And Additives On Polyvinylidene Fluoride (Pvdf) Properties., Niknam Momenzadeh
Electronic Theses and Dissertations
Beyond the beneficial characteristics of smart polymers associated with all polymers such as flexibility and cost fabrication, smart materials exhibit multifunctional behaviors. The prospect of integrating structural and sensing/actuation capabilities into a single structure gives design engineers an ability to innovate highly novel, multi-functional creations. Polyvinylidene Fluoride (PVDF) is one of the widely used multi-functional materials which offers a variety of desirable material properties. It possesses exceptional chemical and UV resistance, biocompatibility, low processing temperature and affordable price making it a competitive choice for many commercial applications. In addition, among polymers, PVDF is simply the most dominant piezoelectric polymer. On …
Fandom From Afar: Identification, Attachment, And Consumption Behaviors Among United States Based Fans Of English Premier League Soccer Clubs., Adam R. Cocco
Electronic Theses and Dissertations
The purpose of this study was to explore the antecedents to organizational identification among U.S.-based EPL fans and examine the relationship between these antecedents and various forms of sport consumption behavior. Specifically, this study examined the extent to which points of attachment explained variances in organizational identification and three types of sport consumption behavior – broadcast media consumption, social media consumption, and team-related merchandise purchases. Additionally, this study examined differences in points of attachment between fans of successful EPL organizations, known as the “Big Six” EPL clubs, and fans of unsuccessful EPL organizations. In contrast to most existing sport fan …
Sulforaphane Protects Against Ethanol-Induced Apoptosis And Teratogenesis Through Epigenetic Modulation Of Anti-Apoptotic Genes., Yihong Li
Electronic Theses and Dissertations
Background. Ethanol-induced excessive apoptosis in neural crest cells (NCCs), a multipotent progenitor cell population, is one of the major mechanisms underlying the pathogenesis of Fetal Alcohol Spectrum Disorders (FASD). However, the molecular mechanisms underlying FASD that results from maternal alcohol exposure during pregnancy are poorly understood. The overall goals of this study are to examine the mechanisms by which ethanol induces apoptosis and malformations in vitro and in vivo, and to develop a nutritional-based approach by using SFN and SFN-rich BSE to prevent FASD through epigenetic modulation. Results. This study demonstrates that ethanol exposure resulted in a significant increase …
Anxiety And How To Control It: The Functional Role Of The Bed Nucleus Of The Stria Terminalis., Lindsay K. Knight
Anxiety And How To Control It: The Functional Role Of The Bed Nucleus Of The Stria Terminalis., Lindsay K. Knight
Electronic Theses and Dissertations
Anxiety disorders afflict up to one third of the population. Research to date has primarily focused on the amygdala, however, new perspectives suggest that a tiny basal forebrain region known as the bed nucleus of the stria terminalis (BNST) may hold key insights into understanding and treating anxiety disorders. Therefore, my first aim was to empirically investigate the importance and influence of the BNST in anxiety processing. Using fearful faces and human screams as aversive stimuli, two threat conditions were created: one in which threats were certain and predictable (fear) and another in which threats were uncertain and unpredictable (anxiety). …
Preventable Hospitalization Among Type 2 Diabetes Patients In Kentucky Before And After Medicaid Expansion 2010-2017., Turky Jamil Arbaein
Preventable Hospitalization Among Type 2 Diabetes Patients In Kentucky Before And After Medicaid Expansion 2010-2017., Turky Jamil Arbaein
Electronic Theses and Dissertations
Objectives: 1) Analyze county level variation in T2DM-PH rates in Kentucky before ACA (2010-2013) and after the ACA (2014-2017). 2) Analyze the relationship between county level socioeconomic factors (income per capita, percentage of uninsured people, percent of urban population, primary care and general preventive offices, population aged 65 and above, median age, household income, percentage in poverty, and unemployment rate ) and county level T2DM-PH rates before (2010-2013) and after (2014-2017) ACA implementation in Kentucky. Method: This research was conducted in two phases: Phase one of this study estimated the county-level PH variation among T2DM patients across eight years (2010-2017), …
Invocation., Shae Taylor Goodlett
Invocation., Shae Taylor Goodlett
Electronic Theses and Dissertations
The research of this thesis is concerned with the investigation of various approaches to religious theory; specifically, the observable analysis of performed ritualistic procedures and their theoretical anticipated effects. Through the examination of the illusory characteristics of the interaction of color and light I am able to draw analogous correlations between art making and ritualistic action. By enacting optical illusion as metaphor for ritual presence, I compare rational and empirical methods of observation. This analysis examines the discrepancy of physical fact and physic effect in that illusion employs physically observable means to render an intangible (non-material) physic effect. Such observances …
Tobacco-Derived Aldehydes: Platelet Activation, Thrombosis, And The Role Of Trpa1., Andre Dwayne Richardson
Tobacco-Derived Aldehydes: Platelet Activation, Thrombosis, And The Role Of Trpa1., Andre Dwayne Richardson
Electronic Theses and Dissertations
Cigarette smoking is the single largest risk factor for cardiovascular disease (CVD) pathophysiology. Numerous researchers have shown potential associations between aldehydes in tobacco-derived aerosols from mainstream cigarette smoke (MCS) or electronic cigarettes (e-cigs) and their cardiotoxicity by damaging blood vessel endothelium. The severity of exposure to these toxicants can furthermore lead to adverse cardiovascular outcomes such as myocardial infarctions, stroke, coronary and peripheral artery disease, or atherosclerosis due to blood clots, a pro-thrombotic event. However, the mechanisms by which levels of harmful and potentially harmful constituents (HPHCs) such as aldehydes induce thrombosis are not well-known. Of specific interest, evidence has …
White Moves First: Unearthing White Privilege In The Modern Board Game., Darrell A. Johnson
White Moves First: Unearthing White Privilege In The Modern Board Game., Darrell A. Johnson
Electronic Theses and Dissertations
This dissertation focuses on the design choices in the modern board game and argues that game designs emerge from and constitute dominant ideologies that endorse and secure white male superiority. This dissertation utilizes Michel Foucault’s archaeological method to “unearth” ideologies that cultural artifacts both emerge from and constitute. The project considers three central questions: 1) How does the locus of production and consumption impact the dominant ideology underlying game design? 2) How do design choices secure and constitute an ideology of white male dominance? 3) What impact does the normalization of white dominance have upon the broader community? This dissertation …
The Role Of Slc7a11 In Controlling Extracellular And Intracellular Redox Environments Of Lung Fibroblasts - Potential Targets For Intervention In Aging And Idiopathic Pulmonary Fibrosis., Yuxuan Zheng
Electronic Theses and Dissertations
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by extracellular matrix deposition by fibroblasts. Aging and oxidative stress increase the susceptibility to IPF. Redox couples, cysteine/cystine (Cys/CySS) and glutathione/glutathione disulfide (GSH/GSSG), and their redox potentials (Eh) quantify oxidative stress. Fibroblasts from old mice maintain more oxidized extracellular Eh(Cys/CySS) than young mice. Microarray shows down-regulation of Slc7a11 potentially mediates this age-related oxidation. Slc7a11 is the key component of system Xc-, an antiporter that imports CySS and exports glutamate. The first aim of this dissertation is to investigate the mechanistic link between Slc7a11 …
The Cardiovascular Effects Of Tobacco Product-Derived Aldehydes: Contribution Of Transient Receptor Potential Ankyrin-1., Lexiao Jin
Electronic Theses and Dissertations
Cardiovascular diseases (CVD) are the leading cause of death in most countries and are significant health and financial burden worldwide. Smoking contributes to more than 480,000 premature deaths annually -- accounting for one of every five deaths in the United States each year. Numerous studies have shown that smoking increases the risk of factors including endothelial dysfunction, thrombosis, and atherosclerosis, which may lead to an incidence of myocardial infarction, coronary artery disease, and stroke. Electronic cigarettes (e-cigarettes) are a new kind of tobacco product, and some studies show that e-cigarettes also could induce CVD since both e-cigarettes and conventional tobacco …
Global Public Relations And Multinational Corporations: The Influence Of Culture On Public’S Reactions To H&M, Dove, And Nivea’S Media Campaigns In The United States And Nigeria, Olayinka Makanjuola
Global Public Relations And Multinational Corporations: The Influence Of Culture On Public’S Reactions To H&M, Dove, And Nivea’S Media Campaigns In The United States And Nigeria, Olayinka Makanjuola
Electronic Theses and Dissertations
This study examined the significant impact of culture on global public relations practices using a case study analysis of Dove, H&M, and Nivea’s media campaigns between 2017 and 2019. The analysis was carried out through a structural comparison between the public’s reaction from the United States and Nigeria. Cultural variations between the two countries were examined, and how the variations impact GPR practices were explored. Social judgment theory, apologia, and image restoration theory were used as the theoretical frameworks alongside Hofstede’s cultural dimensions. This study demonstrates that understanding cultural dimensions as it applies to diverse countries operating in the global …
Portrait Of Modern Pluralism: A Practitioner's Perspective On Interest Group Politics And Theory., Mary Ellen Wiederwohl
Portrait Of Modern Pluralism: A Practitioner's Perspective On Interest Group Politics And Theory., Mary Ellen Wiederwohl
Electronic Theses and Dissertations
This thesis presents a practitioner’s view on interest groups and interest group theory based primarily on Mancur Olson’s conclusions that small, organized minority interests have an advantage over the large, disorganized majority interests in the policymaking process; it tests the “why” behind this theory through an examination of a variety of factors, including the influence of money, the power of communications tools deployed by these interests, and the lobbyists’ role. It includes an introduction plus four chapters, including literature review, research methods, participant observations and in-depth interviews, and conclusion. The research methods included primarily participant observation based on a two-decade …
An Actor's Process In Bridging The Gap Between First-Generation And Multi-Generational African-American Identities., Mutiyat Ade-Salu
An Actor's Process In Bridging The Gap Between First-Generation And Multi-Generational African-American Identities., Mutiyat Ade-Salu
Electronic Theses and Dissertations
This thesis reflects my process assimilating into the role of Chelle in the production of Detroit '67 at the University of Louisville. Although there have been instances of actors crossing lines of gender, nationality, race, and even sexuality, to perform roles in contemporary theatre, discussion about generational differences is almost non-existent. Through historical research, first-hand interviews, and conventional acting methods, I explore the world of my role, searching for spirituality, authenticity, and identity. Additionally, I explain my use of The WAY Method ®, a process I began creating in 2014 to help actors be clear with who they are before …
The Making Of A Person: The Relationship Of Job Crafting And Leisure Crafting On Work Engagement, Occupational Role Salience, Job Performance And Psychological Well-Being., Joshua D. Anna
Electronic Theses and Dissertations
This study looks at how an individuals’ ability to job craft relates to work engagement, job performance and their psychological well-being; and when job crafting opportunities are low, how leisure crafting can compensate to provide the individual similar personal outcomes. This study also examines when job-crafting opportunities are high, how these positive effects can spillover onto other aspects of an individuals’ life such as leisure. This study also examines the extent to which an individual views work as a mean of self-identification and how this relates to job crafting. A total of 303 respondents met the inclusion criteria and completed …
Exosomes From Embryonic Stem Cells As A Prophylactic Vaccine Against Lung Cancer., Shuhan Meng
Exosomes From Embryonic Stem Cells As A Prophylactic Vaccine Against Lung Cancer., Shuhan Meng
Electronic Theses and Dissertations
The antigenic similarity between embryos and tumors has raised the idea of using embryonic materials as a preventative vaccine against neoplastic disease. Indeed, a previous study reported that a vaccine comprised of allogeneic murine embryonic stem cells (ESCs) and murine fibroblasts expressing immune-stimulatory granulocyte macrophage-colony stimulating factor (GM-CSF) successfully blocked the outgrowth of an implantable lung cancer (Lewis lung carcinoma; LLC) and lung tumors caused by a combination of a mutagen followed by chronic pulmonary inflammation. However, such a vaccine is obviously impractical for application to humans. The use of fibroblasts to produce GM-CSF is needlessly complicated, and intact live …
Promoting Healthy Aging: An Investigation Of The Relationships Among Sport Satisfaction, Sport Identity, And Sport Commitment In The Well-Being Of Older Adults., Seonghun Lee
Electronic Theses and Dissertations
People are living longer and the aging population in the U.S. is showing significant growth, but it does mean they are necessarily living healthier lives. Public health representatives recommended people who want to live a healthy lifestyle as they get older need to regularly participate in sport and physical activity earlier in their life because it improves health and psychological and social well-being. However, approximately 80 percent of U.S. adults/older adults are insufficiently active; they participate for fewer than 150 minutes in moderate-intensity physical activity per week. To promote sport engagement, older adult sport and fitness service providers need a …
Development Of In Vitro Models To Study The Rapid Extraintestinal Dissemination Of Salmonella., Adarsh Gopinath
Development Of In Vitro Models To Study The Rapid Extraintestinal Dissemination Of Salmonella., Adarsh Gopinath
Electronic Theses and Dissertations
Salmonella appears in the bloodstream of mice in as little as 15 minutes after oral inoculation and establishes persistent colonies in the spleen and liver. While its pathway to blood is undetermined, this phenomenon is dependent on the activity of Salmonella pathogenicity island 2 (SPI-2) coded type III secretion system (T3SS) and CD18+ phagocytes. We hypothesize that dendritic cells associated with the basal face of the gut epithelium, that are naturally migratory and known to sample for luminal antigens directly transport Salmonella to the bloodstream. This process comprises of at least two phases, dissociation and reverse transmigration. We define dissociation …
Materials-Processing Relationships For Metal Fused Filament Fabrication Of Ti-6al-4v Alloy., Paramjot Singh
Materials-Processing Relationships For Metal Fused Filament Fabrication Of Ti-6al-4v Alloy., Paramjot Singh
Electronic Theses and Dissertations
Additive manufacturing (AM) is at the mainstream to cater the needs for rapid tooling and small-scale part production. The metal AM of complex geometries is widely accepted and promoted in the industry. While several metal AM technologies exist and are matured to a level where expectation in terms of design and properties are possible to realize. But the metal AM suffers from the heavy expense to acquire equipment, isotropic property challenges, and potential hazards to work with loose reactive metal powder. With this motivation, the dissertation aims to develop the fundamental aspects to print metal parts with bound Ti-6Al-4V powder …
Development And Validation Of The Measure Of Perceived Safety In The College Classroom: A Mixed Methods Phenomenological Research Study., Jennifer Ballard-Kang
Development And Validation Of The Measure Of Perceived Safety In The College Classroom: A Mixed Methods Phenomenological Research Study., Jennifer Ballard-Kang
Electronic Theses and Dissertations
In recent years, safety has become a focus of discussion in the field of higher education as research indicates that college students’ perceptions of safety are related to several indicators of student engagement. Despite increased recognition of the importance of safety, there remains a lack of consensus with regard to its definition and conceptualization in the higher education context. This lack of a conceptualization of safety that reflects the complexity of the construct within the postsecondary context has acted as a barrier to the development of quality measurement instruments that can be utilized by researchers and practitioners to understand and …
Coparenting And School Success: Perspectives Of Fathers., Shannon M. Mount
Coparenting And School Success: Perspectives Of Fathers., Shannon M. Mount
Electronic Theses and Dissertations
Historically, measures of coparenting have been reported by mothers. As a result, fathers’ perspectives and experiences have largely been excluded from this body of research. In response, this study relies on fathers own report of coparenting support. This study used a sample of 1255 biological fathers from the Fragile Families and Child Wellbeing Study (FFCWS) to explore fathers’ reports of their coparenting support and how this is associated with relationship status with mother, time spent with child, and several school success variables including: internalizing and externalizing school behaviors and math and reading assessment scores at child age 9. Hypotheses included …
Selective Laser Melting 17-4 Ph Stainless Steel And The Effect Of Varied Thermal Treatments On Fatigue Behavior., Sean Daniel Dobson
Selective Laser Melting 17-4 Ph Stainless Steel And The Effect Of Varied Thermal Treatments On Fatigue Behavior., Sean Daniel Dobson
Electronic Theses and Dissertations
Fatigue failure is the leading source of loss in industry. In order for new means of manufacturing to move towards mainstream use a complete understanding of material and mechanical behavior must be gained. This endeavor seeks to aide in that task by observing the fatigue behavior of selective laser melting (SLM) additive manufacturing (AM) specimens and the effect of differing thermal treatment conditions for an optimized AM process. Stainless steel 17-4 PH specimens were fabricated using SLM AM and thermally treated to three conditions: as-built, solutionized and hardened, and direct hardened. These specimens were characterized for material (powder quality, density, …
Analyzing The Effects Of Of Seasonal Land Cover And Precipitation On The Sediment Delivery Ratio Of An Agriculture Dominated Watershed., Jonah Liebman
Analyzing The Effects Of Of Seasonal Land Cover And Precipitation On The Sediment Delivery Ratio Of An Agriculture Dominated Watershed., Jonah Liebman
Electronic Theses and Dissertations
Soil erosion is of escalating importance as increasing population and climate change have put increasing pressures on agricultural food production. Vegetation and precipitation are two factors that control the amount of soil erosion extant within a region. Sediment delivery ratios (SDRs) assess the ratio of soil eroded from a watershed system that is permanently removed from the system through stream sediment discharge. Using 1) river discharge and sediment concentration data and 2) the Revised Universal Soil Loss Equation (RUSLE), this thesis analyzes fluctuations in monthly SDRs for an average hydroclimatological crop-harvest season for the Senachwine Creek watershed, IL. Through calculating …
Food Insecuity In Historically Disenfranchised Parts Of Jefferson County, Ky., Kaitlyn Smith
Food Insecuity In Historically Disenfranchised Parts Of Jefferson County, Ky., Kaitlyn Smith
Electronic Theses and Dissertations
The objective of this study is to investigate the availability of fresh and nutritious foods in Louisville’s West End communities. This study operates under the assumption that residents in Jefferson County have unequal access to food. This study also addresses the question of how residents and local non-profits feel about strategies that build community through food. This study is significant because across Louisville, more than 120,000 people are living with food insecurity, meaning they don't have reliable access to healthy, affordable food (Dare to Care 2019). Multiple reports that have been commissioned by local non-profits and metro departments in the …
A Content Analysis Of Olivia Pope: How Scandal Reconfirms The Negative Stereotypes Of Black Women., Chelsy Leann Golder
A Content Analysis Of Olivia Pope: How Scandal Reconfirms The Negative Stereotypes Of Black Women., Chelsy Leann Golder
Electronic Theses and Dissertations
The purpose of this study is to answer how Scandal reconfirms the negative stereotypes of black women. Scandal’s leading character, Olivia Pope, embodies the Mammy, the Jezebel, and the Sapphire. These stereotypes were invented during slavery and still used today to justify the current racial and gendered oppression of Black women. A linkage between the stereotypes and Olivia Pope’s character will be made based on an analysis of the television show. A random sampling approach was used to select a total of 14 episodes. Each of the 14 episodes were carefully examined for examples of Mammy-like, Jezebel-like, and Sapphire-like …
Reactive And Regulative Temperament Dimensions, Emotion Regulation, And Concurrent Internalizing And Externalizing Pathology Among Youth With Adhd., Kirsten D. Leaberry
Reactive And Regulative Temperament Dimensions, Emotion Regulation, And Concurrent Internalizing And Externalizing Pathology Among Youth With Adhd., Kirsten D. Leaberry
Electronic Theses and Dissertations
Emerging research has increasingly identified the detrimental effect of internalizing and externalizing comorbidity on the functioning of youth with Attention-Deficit/Hyperactivity Disorder (ADHD). Research in the broad child psychopathology literature has identified a variety of dispositional and developmental risk factors for psychopathology development in youth. However, a conceptual model of psychopathology development has yet to be developed and empirically evaluated in an ADHD sample. Children with ADHD may be particularly vulnerable to exhibiting high rates of psychopathology, given deficits in self-regulation prevalent in this population. The current study proposed and evaluated a theoretical model of distal and proximal risk factors for …
The Development Of A Culturally-Informed Cervical Cancer Screening And Prevention Mhealth Intervention For African American Women., Ariel Washington
The Development Of A Culturally-Informed Cervical Cancer Screening And Prevention Mhealth Intervention For African American Women., Ariel Washington
Electronic Theses and Dissertations
Background: Significant strides have been made in reducing the burden of cervical cancer and HPV. Between pap smear screenings and HPV vaccinations, there has been a reduction in cervical cancer incidence in the United States. Unfortunately, those reductions have not been experienced by all ethnic groups. Cervical cancer disparities are a threat to the health of African American women, and innovation in education and the healthcare experience is needed to eliminate this threat. This study aimed to develop and evaluate a culturally tailored intervention using mHealth services to improve cervical cancer and HPV knowledge. Methods: The development and evaluation of …