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A King's Royal Scars., Xavier Mikal Harris

Electronic Theses and Dissertations

This monograph is divided into five chapters covering my exploration of black male identity in America and the scars that come with it. Through a character study of the black male protagonist I portrayed in August Wilson’s King Hedley II, I will discuss the racial stigmas and circumstances that are tied to black male identity. Chapter one will consist of analyzing the prison system in America and how its unfair system targets black men. Chapter two will discuss the plight of poverty that largely affects black communities. Chapters three and four will discuss King Hedley’s dual identities created by …

Functional Nanomaterials By Combining Aminooxy Chemistry And Iodine Activation At Momolayer Protected Clusters., Tirtha Raj Sibakoti

Electronic Theses and Dissertations

Aminooxy (-ONH₂) groups are most commonly known for their chemoselective reaction with carbonyl compounds (aldehydes/ketones) under mild reaction conditions. Aminooxy-based click chemistry is a versatile means of ligation as evidenced by broad application in material science, biology, biochemistry, analytical chemistry, and nanoscience. Our work exploits the facile reaction of aminooxy groups presented on the surface of gold (Au) or palladium (Pd) monolayer protected clusters (MPCs) with various aldehydes via oximation reactions, which form the robust oxime ether adducts. The functionalization of hexanethiolate-stabilized Au MPCs with a newly developed trifunctional amine-containing aminooxy alkanethiol ligand by thiol place-exchange affords aminooxylated …

Optimization And Simulation Models To Improve Access To Organ Transplantation In The United States., Fatemeh Karami

Electronic Theses and Dissertations

Organ allocation in the U.S. is administrated by the United Network of Organ Sharing (UNOS). UNOS’s mission is to ensure fair and equitable allocation of organs as stated in the Code of Federal Regulations, which reads "neither place of residence nor place of listing shall be a major determinant of access to transplant". Despite the regulations, there has been endless controversy surrounding the disparity in access to organ transplants. In this context, the primary research goal in this dissertation was to reduce geographic disparity in access to transplants in the U.S., with a focus on heart and kidney transplants. To …

A Novel Approach To Hiv Prevention: Understanding Multi-Level Influences On Hiv Pre-Exposure Prophylaxis (Prep) Uptake And Outreach Among African Americans., Suur Debrah Ayangeakaa

Electronic Theses and Dissertations

This dissertation examined and provided basis for addressing factors related to HIV pre-exposure prophylaxis (PrEP) engagement, outreach, and uptake among high-risk African American youth groups in Louisville, KY. This qualitative dissertation study was designed through the lens of an interpretive framework of social constructivism which holds that multiple realities and interpretations exist and are socially constructed through the lived experiences of individuals and their interactions with others. Thus, lived experiences of various African American youth groups in Louisville as well as key informants of AIDS service organizations (ASOs) across the U.S. (including Louisville) were explored to develop a deeper understanding …

Tobacco Product-Derived Aldehydes: Effects On Circulating Angiogenic Cells & Implications For Cardiovascular Disease., Jordan B. Lynch

Electronic Theses and Dissertations

Cardiovascular disease (CVD) is the leading cause of death worldwide. Tobacco smoke is the most significant modifiable risk factor in CVD development and contains numerous toxic compounds, including aldehydes, which have been linked to CVD. Formaldehyde, acetaldehyde, acrolein, and crotonaldehyde have been identified as significant contributors to cigarette-induced health effects, but the mechanism of these effects is not well understood. These aldehydes are also found in aerosols produced by e-cigarettes (e-cigs). The goal of this dissertation was to explore the systemic, hematological, and endothelium-related effects of exposure to tobacco products and constituent aldehydes and to identify potential mechanisms of injury. …

Development Of Rationally Designed Live Attenuated Vaccines For Lassa Fever And Venezuelan Equine Encephalitis., Dylan Macgregor Johnson

Electronic Theses and Dissertations

Lassa Virus (LASV) and Venezuelan Equine Encephalitis Virus (VEEV) are two single stranded RNA viruses belonging to the Arenavirus and Alphavirus families, respectively. Both are emerging pathogens without approved vaccines or treatments. VEEV is an important biothreat pathogen because it has been weaponized and is extremely infectious as an aerosol. VEEV causes biphasic febrile illness that can progress to a viral encephalitis with low mortality, but high morbidity. LASV causes a viral hemorrhagic fever, Lassa Fever (LF), which is endemic in West Africa, and responsible for between 100-500k annual infections with a 1-2% overall mortality rate. ML29 and VEEV TC-83 …

Impact Of Magnetocaloric Material Properties On Performance Of A Magnetocaloric Heat Pump., Michael G. Schroeder

Electronic Theses and Dissertations

In the field of magnetocaloric heat pumps much research has been performed around machine design and theoretical machines, but little has been researched around practical problems such as variability in material properties. The present work defines a simulation tool that has been proven with experimental data. Magnetocaloric material cascades were statistically analyzed and parameterized, such that they could be recreated parametrically using a split Lorentz function with normally distributed parameters. Correlated curve-defining values with standard deviations were used as input into the simulation tool to determine the effect of variation on cooling heat pump performance for a household refrigerator application. …

Role Of Plant Volatile Organic Compounds (Vocs) In Seed Priming And Plant-Herbivore Interactions., Abhinav Kumar Maurya

Electronic Theses and Dissertations

This dissertation explores and expands the existing knowledge on the role of plant volatiles in facilitating seed priming and providing direct defense against herbivore. Although the roles of plant volatiles in priming a plant’s defenses and providing direct defense against pests is well known, information regarding their effects on seed and the fitness of future plants and direct toxicity to herbivores is understudied. This dissertation does a thorough examination of these two understudied aspects of plant volatiles and provides novel insight into the role of plant volatiles in seed priming and direct defense (Chapter I). Seeds in the soil can …

Mechanistic Insight Of The Role Of Nherf1 In Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle

Electronic Theses and Dissertations

Background. Acute kidney injury (AKI) develops in 30% of patients who receive cisplatin, a widely used chemotherapeutic agent. We previously showed that NHERF1 loss resulted in increased susceptibility to cisplatin nephrotoxicity. The overarching goal of this dissertation was to elucidate mechanisms of susceptibility to cisplatin-induced AKI, specifically the effects of NHERF1 loss on tubule cell metabolism, tubule cell mitochondrial function, and alterations in oxidative state and/or renal handling of cisplatin. Methods. 2-4 month male wild type (WT) and NHERF1 knock out (KO) mice were treated with either vehicle control or cisplatin (20 mg/kg dose IP) for 4, 24, and 72 …

The Retinoblastoma Protein Mediates Metabolic Reprogramming In Lung Cancer., Lindsey R. Conroy

Electronic Theses and Dissertations

Lung cancer is among the most frequently diagnosed cancers and is the leading cause of cancer-related deaths worldwide. One of the hallmark events in lung cancer pathogenesis is deregulation of the cell cycle. The retinoblastoma protein (pRb) is a tumor suppressor that is deleted, mutated, or inactivated in most lung cancer cases. Canonically, pRb functions to regulate cell cycle progression by repressing the transcriptional activity of the E2F family of transcription factors, inhibiting S phase entry. Although the cell cycle functions of pRb have been well established, recent studies have highlighted a functional role for pRb in controlling cellular metabolism. …

Examining Corporate Blameworthiness In Relation To Federal Organizational Sentencing For Probation And Corporate Monitors., Emily M. Homer

Electronic Theses and Dissertations

Organizations that have benefitted from the commission of federal crimes committed by their employees may be sentenced to federal criminal penalties. Two of these potential penalties include probation and the requirement to implement a corporate monitor. The federal guidelines provide suggestions for sentencing probation that echo the theoretical focal concern of blameworthiness. This research used eight years of United States Sentencing Commission data covering 2011 to 2018 (n= 1,224) to examine if organizations were being sentenced to probation and monitoring consistent with the federal guidelines and focal concern of blameworthiness. The study examined nine potential measures of blameworthiness …

Hirschman's Voice, Exit, And Loyalty Framework In The Context Of Charter Schools And Secession: A Discourse Analysis Of Indiana Newspaper Editorial Items, 1990 To 2014., Glyptusann Grider Jones

Electronic Theses and Dissertations

In this study, I apply secession to Hirschman’s (1970) classic framework to develop a notion of charter school secession. I build beyond his constructs, which I define as Voice₁, Exit₁, and Loyalty_District in the case of dissatisfaction with traditional school governance, to explore whether there is a rhetorically discernible “battle” in Indiana’s charter school development such that actors: (1) have a crisis of legitimacy (claim) against the local school or district (Voice₂); (2) seek to leverage charter school formation as the mechanism to withdraw and establish independence (Exit₂); and (3) defend …

Black Middle-Class Neighborhoods In Louisville Through Multiple Lenses., Jamar M. Wheeler

Electronic Theses and Dissertations

This dissertation is an articles-based, mixed methods study that analyzes Black middle-class neighborhood attainment in Louisville. Racialized social structure theory is the theoretical framework that is employed to make sense of the adverse positionality of Black middle-class neighborhoods. Racialized social structure theory posits that individuals are placed in racial categories that are hierarchically arranged, which, at the neighborhood level, translates to White and Black householders advancing their material interests in competing ways. These competing interests are asymmetrical in terms of power relations, which means that the neighborhood choices of the Black middle-class are constrained by the routinized ways that the …

The Long Journey Down Market Street: An Oral History Based Biography Of Mary Craik., Denise Vulhop Watkins

Electronic Theses and Dissertations

This interdisciplinary dissertation examines the life of Mary B. Craik, a Louisvillian who was a professor, feminist activist, philanthropist and artist. The project’s main focus is on Craik’s feminist awakening and activism, and their alignment with second wave feminism. The primary method of data collection was oral history and consisted of interviews with Craik and some of her friends, acquaintances, and colleagues. Additional sources included a scrapbook that documented her major life events, the trial transcript from a gender discrimination lawsuit she launched, and art quilts she made in her later years after she retired. This project examines these resources …

Dual Role Of Antimicrobial Peptide Cathelicidin In Alcohol-Associated Liver Disease., Fengyuan Li

Electronic Theses and Dissertations

Patients with alcohol-associated liver disease (ALD) have high morbidity and mortality in its severe forms. One of the major features in different forms of ALD is the altered gut microbiota. Antimicrobial peptides (AMPs) play a crucial role in maintaining gut microbiota homeostasis. LL-37 (known as CRAMP in mouse) is the sole member of the human cathelicidin family and has piqued great research interest for its dual role in modulating microbiota and the immune response in metabolic diseases. Inflammasome activation is an important component of the liver pathophysiology in ALD and requires two signals for its full activation to induce the …

American Nocturne., Zahid Saeed

Electronic Theses and Dissertations

American Nocturne is a photographic meditation on the nature of America. There is a long tradition of American photographers looking around their localities to look for this feeling. Using the aesthetics of straight photography, I have worked with a largeformat view camera to search for America. The prism through which I view America is a mixture of both a veneration, an abiding fascination, and at the same time a deep ambivalence towards an overbuilding, overproducing, and over wasting culture. My hope with American Nocturne is to present my view of America, with its contradictions and its beauty. For me the …

Susceptibility Assessment Of Bank And Floodplain Erosion In Stream Restoration Using A Two-Dimensional Hydrodynamic., Fereshteh Noorbakhsh

Electronic Theses and Dissertations

In the design of stream restorations, boundary shear stress (shear stress) and velocity during high flow events are the key parameters in the assessment of the risk of morphological failure associated with channel bank and bed erosion and sediment transport. The use of two-dimensional hydrodynamic models (2D Models) is becoming more common to estimate critical shear stress and velocity for stream restoration projects. These models can give detailed distribution of shear stress and velocity over floodplain surfaces and channel. Obtaining reliable and correct estimates of stress and velocity require an accurate digital terrain model, estimates of input flows at the …

Identifying Protective Factors Against Overweight And Obesity Within The Social Environment Of Women With Low Incomes., Monica M. Adams

Electronic Theses and Dissertations

Over two-thirds of the United States population have overweight or obese (OW/OB) weight statuses due in large part to an obesogenic environment that encourages unhealthful weight related behaviors. The obesogenic environment appears to place a larger burden on women with low incomes as they experience OW/OB disproportionately compared to other groups. Studies seeking to understand the impact of the obesogenic environment on this population have been deficit focused, largely examining environmental risk factors for OW/OB and ignoring protective factors against it. Most women with low incomes do not have an obese weight status and some women who have OW/OB statuses …

Hotel De Vagabundos: Reviewing African American Theatre Journey., Manuel Francisco Viveros

Electronic Theses and Dissertations

This analysis examines how Hotel de Vagabundos, a play written by a black playwright from Colombia, fits into the core of definitions of Black Theatre in the United States. I will examine six documents I consider relevant to shape the idea of Black Theatre in the US from 1900 through 2005. The author's experience in New York during the 1940s inspires Hotel de Vagabundos. The author navigates the globalized ethos idea unleashing clashes about identity to criticize aspects of American culture about immigrants, poor people, and internalized racism within African American and Black diasporic communities. The play “like a …

Modulation Of Host Innate Immune Cells By Yersinia Pestis To Create A Permissive Environment For Replication., Amanda Rose Pulsifer

Electronic Theses and Dissertations

Yersinia pestis has gained widespread infamy due to the historic outbreak during the middle ages, referred to as The Black Death. Infection with Y. pestis typically begins with deposition of Y. pestis into the dermis (bubonic plague) or respiratory tract (pneumonic plague). Tissue resident macrophages are the first innate immune cell encountered by Y. pestis. Macrophages are likely a way for Y. pestis to avoid neutrophils early in infection when the neutrophil neutralizing Type Three Secretion System is not expressed. This work focuses on which Rab host proteins are manipulated by Y. pestis, and how neutrophils are forced to …

The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina

Electronic Theses and Dissertations

Periodontitis is an irreversible, chronic inflammatory disease where pathogenic microbial communities accumulate in the gingival crevice. Advances in culture-independent techniques have facilitated the identification of new bacterial species in periodontal lesions, such as the Gram-positive anaerobe, Filifactor alocis. Neutrophils are a major component of the innate host response, and the outcome of their interaction with F. alocis may be a determinant of oral health status. While neutrophil functions typically protect the host against periodontal disease, oral pathogens have adapted to evade or disarm neutrophil microbicidal functions while promoting mechanisms that drive inflammation, which also provides a source of nutrients …

Tobacco Smoke Exposures And Fertility-Related Outcomes Among Females Seeking Fertility Care, And The Interaction With N-Acetyltransferase 2 (Nat2).., T'Shura S. A. Ali

Electronic Theses and Dissertations

Cigarette smoke contains thousands of harmful substances and is one of the leading preventable causes of mortality and morbidity in the United States. Past studies examining tobacco smoke exposures on fecundability and pregnancy outcomes are inconsistent. NAT2 is an important enzyme in the metabolism of xenobiotic substances found within tobacco smoke. This preconception cohort study examines associations between active smoking and secondhand smoke exposure (SHSe) on fecundability and spontaneous abortion (SA), and explores a possible interaction with NAT2 acetylator status. A total of 223 women seeking fertility care were followed for up to 2.3 years. Preconception tobacco smoke exposures were …

Risks Of Indirect Trauma Among Direct Support Professionals Who Work With Adults With Intellectual/ Developmental Disabilities: Impact On Organizational, Staff And Client Outcomes., Daniel A. Boamah

Electronic Theses and Dissertations

Direct support professionals (DSPs) provide a wide range of support services to persons with ID/DD to ensure their safety and welfare, development of independent living skills and integrate into their community. Existing literature has shown that as frontline workers, DSPs face various occupational hazards such as burnout, yet very little is known about prevalence of secondary trauma stress (STS) among DSPs.

The present study examines the prevalence of STS and the predictive factors of STS and burnout among DSPs who work with adults with ID/DD. In addition, the study looked at the relationships between burnout and STS on organization-related outcomes, …

Aboveground-Belowground Interactions: Roles Of Soil Biotic And Abiotic Factors On Switchgrass's (Panicum Virgatum) Growth, Defense Against Herbivory And Cell Wall Chemistry., Binod Basyal

Electronic Theses and Dissertations

Plants constantly interact with their biotic and abiotic soil environments. Most terrestrial plants form beneficial associations with soil microbes such as arbuscular mycorrhizal (AM) fungi, which are widely known for their ability to transfer soil phosphorus and nitrogen to the host plants. They help plants tolerate drought stress and improve plant defense against herbivores such as plant-parasitic nematodes (PPNs). This dissertation investigates the role of AM fungi on switchgrass’s (Panicum virgatum) growth, cell wall chemistry, and defense against PPNs using a combination of growth chamber and field studies. Switchgrass is a native warm-season species which is gaining traction as candidate …

Evaluation Of Metal Concentration In Water And Soil In The Southern Region Of Lake Nacogdoches, Olawunmi Taiwo

Electronic Theses and Dissertations

The concentrations of metals (Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, V, Zn) were investigated in soil and water samples collected over four different sites in the southern part of Lake Nacogdoches over one year from August 2018 through June 2019. Water samples were analyzed using the USEPA method 200.8 part 11.2 for total recoverable metals. Soil samples were analyzed using the USEPA method 3050B for total recoverable metals. Although the total concentration gives some indication of the level of contamination, it is not enough to give information on the bioavailability or mobility of the element. A modified …

Quality Of Life Of Adults Who Have Attempted Suicide, Karen Hoefer

Electronic Theses and Dissertations

This study focuses on the quality of life of suicide attempt survivors and the trajectories of their lives after their last attempt in the past two to ten years. Employing both a quantitative and qualitative approach but focusing largely on the qualitative data, I collected demographic data, gathered responses on an abbreviated Reasons for Living Inventory, and conducted open-ended phone interviews with 26 participants. The primary life course finding is that participants’ suicide attempts are often built on years of dealing with mental illness. The analysis also dispels many stereotypes associated with people who have attempted suicide. I explore patterns …

Teaching Decoding Through Constant Time Delay To Students With Severe Disabilities And Verbal Difficulties, Julia Dean

Electronic Theses and Dissertations

The purpose of this study was to examine the effects of constant time delay on decoding letter sounds within consonant-vowel-consonant words and to read constant-vowel-constant words skills for students with severe disabilities and verbal difficulties. This study used a multiple probe across participants design with four students with severe intellectual and/or development disabilities. Results indicated a functional relation between the use of constant time delay and decoding of CVC words. Additionally, students were able to maintain and generalize learning. Results were similar to other studies which implemented constant time delay to promote emergent literacy skills. Practitioners can use constant time …

The Effects Of Self-Regulation Depletion And Race On The Willingness To Interact With Individuals With Mental Illness, Kenocha K. Epperson

Electronic Theses and Dissertations

Although the discrimination that Black individuals encounter is unique, it is similar in some ways to the discrimination experienced by individuals with mental illness (Corrigan & Wassel, 2008; Follmer & Jones, 2018; Jackson & Stewart, 2003). Research has found that these kinds of stigma can be overridden (Baumeister et al., 1998), but doing so requires self-regulation, which can be depleted (Gailliot et al., 2007). Because stigma exists against both Black individuals and those with mental illness, and because self-regulation is necessary to override those stigmas, the purpose of this project was to examine the relationships to which Black participants would …

An Investigation Of Anxiety- And Depression-Like Behavior After Head Trauma In Mice, Sean K. Payne

Electronic Theses and Dissertations

Every year around 2 million people in the United States (US) suffer a traumatic brain injury. Those people are often at a higher risk of post-TBI psychiatric illness, like anxiety and depression. Animal models of TBI are a useful way to measure such psychiatric illnesses in a pre-clinical setting. There were two purposes of this study: the first being to test the modified Marmarou TBI model, and second to investigate anxiety- and depression-like symptoms in C57Bl6/J mice following a TBI. The modified Marmarou model used different weights (95g, 30g, & sham) to see how severity affected the manifestation of anxiety-like …

A Novel Mathematical Model Of The Trojan Y-Chromosome Strategy With Optimal Control, Christopher Turner

Electronic Theses and Dissertations

Invasive species are a prevalent problem all over the world. Controlling and eradicating an invasive species is an even more diffcult problem. The Trojan Y Chromosome (TYC) eradication strategy is one control method. This method alters the female to male sex ratio by introducing sex reversed males called supermales. These sex reversed males can only produce male progeny. Mathematical models of this strategy have shown that a population can be driven to extinction with a continuous supply of these sex reversed males. There are many different mathematical models of this strategy, but most have serious flaws, such as negative solutions …