Digital Commons Network^™

Metal-Organic Frameworks As Bacteria Mimicking Delivery Systems For Tuberculosis, Ailin Guo

Electronic Theses and Dissertations

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M.tb), with an estimated 1.5 million deaths and 10 million infections each year. Although TB can be effectively treated with antibiotics, because of the complications and length of treatment, many people fail to complete the treatment which exacerbates the emergence of drug-resistant M. tb strains. The goal of this work is to develop biomimetic particles as host-directed therapy to target the infected macrophages. Two types of metal-organic frameworks (MOFs), MIL-100(Fe) and MIL-88A(Fe) were developed for bacteriamimicking particles. As a proof-of-concept, Mannose was selected as a ligand to target macrophages because …

A Bitten Apple And A Bloody Key: Feminist Revisionism At The Intersection Of The Eden Myth And The Bluebeard Tale, Jacob Ford

Electronic Theses and Dissertations

This thesis investigates the feminist revisionism of the Bluebeard fairy tale through a focus on its relationship with the Eden myth. Past studies have examined the remarkable feminism of Bluebeardian literature and history, but this thesis is the first to interrogate the tale’s evolution from and alongside the Eden myth and to argue that the Bluebeard tale’s feminism is exceptional because of its ties to the Eden myth. I argue that the evolution of the intersecting revisionism of the Eden myth and the Bluebeard tale is characterized by the changing morals of the two myths—morals that, depending on the author’s …

An Exploration Of The Effects Of An Early Postpartum Intravenous Infusion With Carnosic Acid On Physiological Responses Of Transition Dairy Cows, Tainara Michelotti

Electronic Theses and Dissertations

The transition period is commonly defined as the last 3 wk before parturition to 3 wk after parturition. It is the most critical stage of the lactation cycle of high-producing dairy cows. The period consists of a complex interplay of metabolic and hormonal adaptations, inflammation, and immune activation. During the transition period, dairy cows commonly face oxidative stress, an underlying factor for dysfunctional immune response and enhanced inflammation, which can further increase the susceptibility of dairy cattle to health disorders and decrease productivity. In the last few decades, there has been an increased interest in studying alternative natural compounds with …

Auxin-Based Herbicide Program And Rhizobia Application For Weed Control And Nodulation Potential In Auxin Tolerant Soybean, Joy Amajioyi

Electronic Theses and Dissertations

Foliar-applied Bradyrhizobia to V4 soybean has been reported to increase yield up to 5%. However, a stand-alone product application may not be practical. Applying with other treatments such as post-emergence herbicide application may be economical but herbicide and/or additives may be deleterious to rhizobial growth. A laboratory study investigated the impact of herbicides (glyphosate and dicamba), additives (an oil to improve absorption and spreading; and AMS used to overcome hard water impacts on glyphosate), and herbicide + additives on bacterial growth. Optical density (OD) measurements at the wavelength of 650 nm assessed solution turbidity, a surrogate measure of bacterial growth. …

Development And Properties Of The Roc-Abc Bayes Factor For The Quantification Of The Weight Of Forensic Evidence, Jessie Hendricks

Electronic Theses and Dissertations

Many scholars have proposed the use of a Bayes factor to quantify the weight of forensic evidence. However, due to the complex and high-dimensional nature of pattern evidence, likelihood functions are intractable and thus, Bayes factors cannot be assigned using traditional methods. Approximate Bayesian Computation (ABC) model selection algorithms provide likelihood-free methods to assign Bayes factors. ABC Bayes factors leverage the use of the scoring functions commonly used in recent years in forensic statistics in a rigorous statistical manner. However, traditional methods for assigning ABC Bayes factors are subject of several criticisms. In this dissertation, one of the main criticisms …

Studies On Genetic Characterization Of Agronomic Traits And Disease Resistance In Bread Wheat, Jyotirmoy Halder

Electronic Theses and Dissertations

A steady increase in wheat yield is vital to feed the continuously rising world population. Systematic exploitation of wheat germplasm and a better understanding of the underlying genetic control could be pivotal in accelerating the genetic gain for yield and disease management. Various modern techniques such as genome-wide association study (GWAS), genomic selection (GS), fine mapping, and cloning can expedite wheat improvement and broaden our understanding of the complex wheat genome. In the first objective of this study, we evaluated the Watkins core set of 121 landrace cultivars (LCs) to identify novel sources of resistance against the tan spot, Stagonospora …

Search For New Fertility Markers In Bull Sperm, Saulo Menegatti Zoca

Electronic Theses and Dissertations

Sperm are stored for extended periods of time in the epididymis, but upon ejaculation motility is increased and lifespan is decreased. After insemination, sperm must traverse the female barriers and undergo capacitation to complete fertilization; however, there are differences in fertility even among bulls that successfully pass a breeding soundness exam. For any potential marker of fertility, there must be variability expressed among animals. The series of studies in this dissertation had the objective 1) to evaluate differences between epididymal and ejaculated sperm and respective fluids proteins to understand increased longevity of epididymal sperm; 2) to evaluate the potential of …

Lessons Learned Through Time: An Examination Of The 1918 Influenza Pandemic And The Covid-19 Crisis, Stephanie Lee Poiroux

Electronic Theses and Dissertations

The purpose of the present study is to compare the United States’ federal and state response to the 1918 Influenza Pandemic and the 2020 COVID-19 Crisis and the role of bureaucracy. Utilizing Qualitative Content Analysis, I examined 300 newspaper articles from The New York Times, The Clarion-Ledger, and The Daily Clarion-Ledger from July 1, 1918, to December 31, 1918, and March 1, 2020, to August 31, 2020. Through this analysis, I found that federal and state governments reacted to the 1918 flu very quickly, whereas the response to COVID-19 was hindered due to political in-fighting that impeded the bureaucracy and …

Effect Of Chronic Pain On Prospective Memory Performance, Alexander Joseph Kuka

Electronic Theses and Dissertations

Chronic pain is among the most widespread and disabling conditions worldwide. In the United States, approximately 50 million people suffer from chronic pain, and nearly half that number experience daily chronic pain. Diagnostic testing, treatments, and operations related to chronic pain cost Americans over $600 billion annually. Prospective memory, the process by which people remember to perform an action in the future after a delay, appears to be affected by the experience of pain, especially when a prospective memory task is more cognitively demanding. While self-report studies of individuals with chronic pain suggest that pain adversely affects both their retrospective …

The Accuracy Of Subjective Load Parameters In Comparison To Analytical Load Measurments In Ncaa Division I Women’S Volleyball, Katherine Pierce

Electronic Theses and Dissertations

Monitoring the work load of athletes in both an individual and team setting has become a commonplace practice in today’s age of sports. However, this practice can look different depending on the physical demands of the sport. Specifically, in volleyball, an inertial measurement unit, known as Vert, can be utilized to track the number of jumps performed by players, in addition to other jump related variables. While Vert serves as an effective way of objectively measuring jump frequency among players, other ways in which jump frequency can be estimated are needed for teams and players without Vert. Therefore, this study …

Dislocation Mechanics Of Total Hip Arthroplasty: A Combined Experimental And Computational Analysis, Michael Scinto

Electronic Theses and Dissertations

While total hip arthroplasty is considered a successful procedure, dislocation remains a serious complication as recurrent dislocations may require additional surgeries. Knowledge on dislocation events as they occur in vivo are limited, therefore researchers rely on experimental and computational methods. A custom MATLAB script and an experimental procedure utilizing a six-degree of freedom actuator were developed to further understand how various surgical considerations affect dislocation mechanics in total hip arthroplasty. Computationally, it was determined that impingement free range of motion is limited during internal rotation in flexion and during external rotation in extension. Experimentally, our results suggest that the posterior …

Instructional Coaching For Culturally Responsive Pedagogy, Kelly Shorb

Electronic Theses and Dissertations

Growing up with a global perspective and teaching in highly diverse schools has fueled my desire to understand how instructional coaching and Culturally Responsive Pedagogy work together in education. This case study examined the current practices of instructional coaches to understand how they incorporate components of Culturally Responsive Pedagogy. Through observations and interviews of three coaches and a director this study explored the interactions, behaviors and language of coaches as they engaged with teachers to explore and understand prior knowledge, beliefs and current incorporation of CRP with teachers. The literature review provides an in-depth description of each of the components …

Evaluating Foundational Components Of Research Consultations In An Academic Library Research Center, Ryan F. Buller

Electronic Theses and Dissertations

As our society continues to evolve at an ever-increasing rate, our higher education institutions, and the services they provide, must keep pace with societal changes in order to ensure that those services stay current and relevant. This program evaluation examines one such service, the research consultation model in University Libraries at the University of Denver. This evaluation was situated within the Human Ecological Theory Framework, to help understand how different environments can impact the recognition and value placed upon the foundational components of the service. An exploratory sequential mixed methods approach was used to determine what the foundational components of …

The Ghost Town: An Autoethnographic Study On The Effects Of Loss And Trauma On A Saudi Arabian International Student’S Well-Being, Salman J. Alzowibi

Electronic Theses and Dissertations

We all have fought on grief’s battleground; some of us started at early ages, while others during their developmental age, teen’s years, or later in their adulthood. All of them are valuable resources and sites of knowledge that need to be explored. Yet, recent studies reduced grief into clinical psychological well-being. However, as I lived these experiences, trauma, loss, and grief impact all well-being dimensions. Grief intersects with large structures (e.g., social, economic, cultural, locations, etc.); all these components impact our way of grief how socially displayed (mourning). This dissertation encapsulates my personal experience elevating it to an academic work …

Exponential Random Graphs And A Generalization Of Parking Functions, Ryan Demuse

Electronic Theses and Dissertations

Random graphs are a powerful tool in the analysis of modern networks. Exponential random graph models provide a framework that allows one to encode desirable subgraph features directly into the probability measure. Using the theory of graph limits pioneered by Borgs et. al. as a foundation, we build upon the work of Chatterjee & Diaconis and Radin & Yin. We add complexity to the previously studied models by considering exponential random graph models with edge-weights coming from a generic distribution satisfying mild assumptions. In particular, we show that a large family of two-parameter, edge-weighted exponential random graphs display a phase …

Development Of Triangular And Tetrahedral Finite Elements For Solutions To Thermoelastic Instabilities Using Hotspotter, Cortney Samuel Leneave

Electronic Theses and Dissertations

The objective of the work presented in this thesis is to develop first-order triangular and tetrahedral elements for solutions to Thermoelastic Instabilities (TEI) regarding sliding friction systems in Hotspotter.

Hotspotter software uses a finite element method and an eigenvalue method and is an important tool because currently no other commercial software exists which solves the TEI problem for critical velocities and wave numbers of a system. Hotspotter currently uses quadrilateral and hexahedral elements for two and three dimensional analysis, respectively. Typically, tri and tet elements are used in industry when doing static and dynamic stress analysis. Therefore, the Hotspotter user …

Uncovering An Alternative Social Structure To Social Dominance: A Blend Of Ethnography And Community Based Participatory Research, Andrew A. Fox

Electronic Theses and Dissertations

This study investigated social structures that are alternative to the prevailing assumption of Social Dominance Theory (SDT), which is that all human interaction is based on social hierarchies. The implications of social dominance impact health at an institutional, interpersonal, and intrapersonal level. The intersection of these levels of social dominance cause health disparities that perpetuate gaps between populations. This study explored one community organizing group who is challenging social dominance by creating alternative social structures. The methods of this study included Community Based Participatory Research (CBPR) and Arts Based Research (ABR) as ways to generate middle-range theorizing and attempt to …

Broadening The Capability Of Kinetics Analysis In Biomechanics, Nicholas Nelson

Electronic Theses and Dissertations

Two studies are discussed in this manuscript each preceded by a literature review of the topic. The first review and study explore agility movements and the effect that alternative upper designs in shoes might have on ground reaction force measures of performance. The second review and study evaluate methods of predicting ground reaction forces without the use of a force platform. A method of using effective forces and ways of improving its accuracy are evaluated in depth.

Pulling Back The Curtain: A Student Collaborative Case Study Of Equity Issues In Colorado’S School Finance System, Amy Jo Schwartz

Electronic Theses and Dissertations

After the Great Recession, a seven percent decrease in funding ended decades of academic growth and further widened the achievement gap between White and Black students (Jackson et al., 2020). Colorado’s school-finance system is particularly distorted and inequitable because of a series of tax-limiting policies which, combined, have led Colorado to become one of the lowest-funded per pupil states in the country (Resnick et al., 2015). The purpose of this study is to describe the policymaking context, as it relates to equity within Colorado’s school-finance system and explore policy alternatives to improve equity within the system. The study was designed …

Computational Modeling Of Climate Attributes And Condition Deterioration Of Concrete Highway Pavements, Salma Sultana

Electronic Theses and Dissertations

An efficient and safe road network secures the nation’s economy and prosperity by providing public mobility and freight transport. Maintenance and rehabilitation of the road network cost billions of dollars annually. Road and highway infrastructures performance in any country is impacted by load repetitions and it is further compromised by climate attributes and extreme weather events. Damages to roads and bridges are among the infrastructure failures that have occurred during these extreme events. If maintenance and rehabilitation are not done promptly, the damages to the road caused by heavy traffic and extreme climate may lead to life-threatening conditions for road …

Quantitative Effects Of Electrodialysis Membrane Fouling, John Malone

Electronic Theses and Dissertations

To meet the ever-increasing global demand for fresh water, research is constantly being conducted on separation and purification methods. Electrodialysis (ED) is one of the major technologies that seems able to make significant headway in combatting water shortages. As with all technologies, it is limited by certain aspects, one of those being membrane fouling. This research takes a look at the surprisingly unexamined phenomenon of membrane fouling in ED systems. The ED system studied was tested using conductivity probing, limiting current density analysis, and quartz crystal microbalance with dissipation analysis. Investigation of fouling effects commonly seen in ubiquitous ED systems …

Search For Cpt And Lorentz Invariance Violation In The Muon G-2 Experiment At Fermilab, Meghna Bhattacharya

Electronic Theses and Dissertations

The Muon g-2 experiment at Fermilab (E989) aims to measure the anomalous magnetic moment of the muon, $a_{\mu}= (g-2)/2$, to a groundbreaking precision of $140$ ppb, obtaining a near four-fold increase in precision over the previous experiment, E821, at the Brookhaven National Laboratory (BNL). The value of $a_{\mu}$ from BNL currently differs from the Standard Model prediction by $\sim 3.7$ standard deviations, suggesting the potential for new physics and therefore, motivating a new experiment.Because the theory predicts this number with high precision, testing the g-factor through experiment provides a stringent test of the SM and can suggest physics beyond the …

Development, Optimization, And In Vitro Characterization Of Different Anesthetic Wound Products, Alia Alshammari

Electronic Theses and Dissertations

ABSTRACTAcute and chronic wounds can be a significant source of pain. In the past, pain associated with chronic wounds has been perceived as an inevitable complication of wound care. Fortunately, recent approaches in wound care have developed strategies to prevent and reduce pain when carrying out wound care. Local anesthetics have been used to that end. Lidocaine is the most widely used topical anesthetic in wound care. However, literature on topical Lidocaine has focused almost exclusively on the clinical application on intact skin. This dissertation aims to advance our understanding of anesthetic wound product formulation and development. Anesthetic wound ointments …

Black Grocers, Black Activism, And The Spaces In Between: Black Grocery Stores During The Mississippi Freedom Struggle Movement, Keon Ahmad Burns

Electronic Theses and Dissertations

This thesis explores the role of Black-owned grocery stores and their owners during the Mississippi Freedom Struggle Movement. The thesis highlights four Black grocery store owners, and the impact they had on the movement. Grocery stores played a vital role and were often sites of contestants. Black-owned grocery stores served as meeting spaces for Black activism, targets of White domestic terrorism, and safe havens for Black Mississippians. These spaces provided a space for political agency, leisure, and safety. Likewise, this thesis centers Black grocery store owners as fundamental to the progress of the movement. It explores an array of ways …

Sleep And Health-Related Quality Of Life Among Persons With Parkinson’S Disease And Their Caregiverssleep And Health-Related Quality Of Life Among Persons With Parkinson’S Disease And Their Caregivers, Sushmitha Inguva

Electronic Theses and Dissertations

This dissertation aimed at filling gaps in the body of Parkinson’s disease (PD) and sleep literature by synthesizing and appraising current knowledge on the influence of sleep on health-related quality of life (HRQoL) in persons with Parkinson’s (PWP) and their caregivers, conducting a psychometric evaluation of a HRQoL instrument among PWP, and applying a novel method to assess the dyadic relationship between sleep and HRQoL in PWP and their caregivers. First, the systematic literature review results showed that nocturnal and diurnal sleep problems among PWP are strong predictors of their HRQoL. Additionally, studies that focused on caregiver outcomes showed that …

The Role Of Acetylcholine In Attention And Lapses In Attention In Rats Using The Mode And Deviation From Mode Of Reaction Time Latency, Scott Lee Mitchell

Electronic Theses and Dissertations

Attention Deficit-Hyperactivity Disorder (ADHD) is currently the neurodevelopmental disorder most commonly diagnosed in children in the United States, and one of the defining characteristics of ADHD is inattention. Inattention is marked by increased lapses in attention, and when assessed clinically, it has been highly correlated with reaction-time variability (RTV). Evidence from the human/clinical literature has shown an inherently higher RTV to be the primary quantitative indicator of an ADHD diagnosis. Reaction-time distributions are characterized by an asymmetrical rightward skew, and because of the prevalence of this presentation, it has been theorized that the distribution peak and skew represent separate phenomena, …

Convective Heat Transfer Enhancement Of A Channel-Flow Using Synthetic Jet, Pravesh Pokharel

Electronic Theses and Dissertations

A transient numerical simulation was carried out using ANSYS Fluent, to investigate the convection heat transfer enhancement of the air channel flow using the synthetic jet. Keeping the dimensional parameters of the domain fixed, averaged channel flow velocity was varied up to 3m/s. The diaphragm displacement effect on synthetic jet was studied, ranging the peak-to-peak displacement value from 0.4 to 1.2mm with increment of 0.4mm. Three locations were studied to determine the best operating location of the synthetic jet. Also, frequencies were varied up to 200Hz with every 50Hz increment, from initial condition of 50Hz. It was found that the …

The Perceptions Of Rural College Students On The Impact Of High School College Counseling On College Choice, Tommy Glen Walker

Electronic Theses and Dissertations

Making decisions about college can be challenging for rural students. Guidance counselors and other adults influence these decisions because of their close relationships in high schools and communities. Since rural students are coached into pursuing college as a mechanism for obtaining a better life, it is beneficial to explore their lived experiences regarding college counseling and college choice. This dissertation in practice explores the perceptions of rural college students on the impact of high school college counseling on college choice.

Dachash: A Dynamic, Cache-Aware And Concurrent Hash Table On Gpus, Hao Zhou

Electronic Theses and Dissertations

GPU acceleration of hash tables in high-volume transaction applications such as computational geometry and bio-informatics are emerging. Recently, several hash table designs have been proposed on GPUs, but our analysis shows that they still do not adequately factor in several important aspects of a GPU’s execution environment, leaving large room forfurther optimization.

The Biggest Winner: How Loss Aversion And Negativity Bias Can Increase Affective Polarization, Austin Cutler

Electronic Theses and Dissertations

Affective polarization is on the rise, which makes understanding the origins of it increasingly important. Some work finds that partisan sorting is associated with increased polarization, due to a lack of exposure to conflicting opinions as well as the ease of making generalizations about the opposing side (Iyengar2019-zg). Individuals with more closely aligned ideological and partisan identities are more likely to exhibit hostility towards the other party, and react more emotionally to information that threatens their party or issue stance (Mason2015). The aim of this paper is to analyze how contextual factors, specifically the partisan distribution of an area, can …