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Novel Statistical Approaches For Missing Values In Truncated High-Dimensional Metabolomics Data With A Detection Threshold., Jasmit Sureshkumar Shah May 2017

Novel Statistical Approaches For Missing Values In Truncated High-Dimensional Metabolomics Data With A Detection Threshold., Jasmit Sureshkumar Shah

Electronic Theses and Dissertations

Despite considerable advances in high throughput technology over the last decade, new challenges have emerged related to the analysis, interpretation, and integration of high-dimensional data. The arrival of omics datasets has contributed to the rapid improvement of systems biology, which seeks the understanding of complex biological systems. Metabolomics is an emerging omics field, where mass spectrometry technologies generate high dimensional datasets. As advances in this area are progressing, the need for better analysis methods to provide correct and adequate results are required. While in other omics sectors such as genomics or proteomics there has and continues to be critical understanding …

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Using An Audience Response System To Calibrate Dental Faculty Assessing Student Clinical Competence., Sean A. Aiken May 2017

Using An Audience Response System To Calibrate Dental Faculty Assessing Student Clinical Competence., Sean A. Aiken

Electronic Theses and Dissertations

In order to best prepare students to become competent and confident practitioners in a clinical environment upon graduating dental school, it is imperative for them to receive consistent and productive feedback from the supervising faculty. Through academic engagement, and more specifically faculty calibration, it may be possible to eliminate the disconnect that sometimes exists between faculty expectations and terminology, and those of the students. In terms of definitions, academic engagement reflects faculty scholarly development activities that support integration of relevant, current theory of best practices consistent with the school's mission, expected learner outcomes, and supporting strategies.1-6, 32 The difficulty lies …

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Finding Exuberance For The Role Shelby In Baltimore., Danielle Smart May 2017

Finding Exuberance For The Role Shelby In Baltimore., Danielle Smart

Electronic Theses and Dissertations

This thesis documents my discovery of exuberance as the key to a successful performance and reveals the challenges I faced in developing a character whose major actions in the play fall into the category of masking (i.e. hiding, avoiding, dodging). I define exuberance and discuss how I came to understand that sustaining exuberance requires a great deal of technical expertise specifically in acting, movement and voice in order to accommodate the demands of the character. I contend that exuberance also requires commitment and nurturing of the actor’s personal artistic vision. This thesis will discuss some of the difficulties I faced …

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Building The Bastard : Confidence Through Preparation In Shakespeare's King Lear., Shaleen Tarun Cholera May 2017

Building The Bastard : Confidence Through Preparation In Shakespeare's King Lear., Shaleen Tarun Cholera

Electronic Theses and Dissertations

This thesis is to chart my discovery that confidence is essential to an actor’s craft. This thesis focuses on my performance as Edmund in King Lear, as well as my production the previous summer playing Hussein in Ayad Akhtar’s Disgraced. I draw from a variety of sources, such as meditation and formal acting exercises, to achieve confidence. Most importantly, I distill my missteps as an actor for a better understanding of what hinders confidence when building a role for performance.

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A Spatial Analysis Of The Relationship Between Violent Neighborhood Crime Rates And Alternative Gentrification Indicators In Louisville, Ky (2010-2016)., George A. Noonan May 2017

A Spatial Analysis Of The Relationship Between Violent Neighborhood Crime Rates And Alternative Gentrification Indicators In Louisville, Ky (2010-2016)., George A. Noonan

Electronic Theses and Dissertations

This study analyzes recent findings analyzing coffee shops as alternative indicators of gentrification and the spatial relationship to violent crime. This thesis seeks to add to this literature by providing additional alternative gentrification indicators such as breweries, distilleries and wineries. The change in number of coffee shops, breweries, distilleries and wineries may impact crime rates and multiyear average incidences of homicide and robbery in the city of Louisville, KY. The first hypothesis states that gentrification decreases multiyear average robberies per census tract from 2010 to 2016. The second hypothesis states that gentrification decreases multiyear average homicides per census tract from …

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Examining The Link Between Press Freedom And Politics., Megan Wollerton May 2017

Examining The Link Between Press Freedom And Politics., Megan Wollerton

Electronic Theses and Dissertations

Freedom of the press is a hallmark of liberal democracy. Denying this civil liberty emboldens a government to exert an undue degree of influence over its citizens. By comparing the media discourse in a democratic country to the media discourse in an authoritarian country, one could reasonably expect to identify unique language markers, which shed light on their divergent political climates. This study specifically sourced articles from the Venezuelan publication El Universal and the Costa Rican publication The Tico Times. The author then analyzed every article related to politics published by both newspapers in March 2014 and in March …

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Student Attitudes On Social Media And Perception Of Instructor Social Media Use., Abi Mathew John May 2017

Student Attitudes On Social Media And Perception Of Instructor Social Media Use., Abi Mathew John

Electronic Theses and Dissertations

The purpose of this study is to understand what student attitudes are toward using social media in the classroom and if those attitudes influenced how they perceive instructors using social media in the classroom. Implementing a mixed method approach, this study conducted focus groups to gain an in-depth understanding of what student attitudes were and why they held those ideas. A survey was then distributed to the students’ in a Midwestern University to see if there was a relationship between students attitudes and their perceptions of instructors who use social media. Results showed that students do hold a positive attitude …

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"Given Time..." For Soprano And Orchestra., Alex Isackson May 2017

"Given Time..." For Soprano And Orchestra., Alex Isackson

Electronic Theses and Dissertations

The title of this work, Given time… is meant to be less like a traditional title and more like the beginning of a deep thought. Time is one of those things that I think humans just don’t understand and don’t give very much thought to, especially considering how much time has already passed and how much time left there is in the universe. Where does space and time end? And where do we (or I) fit in all of it? Does everything I do have any lasting impact on the eternal scheme of things? The list of questions goes …

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The Effects Of Moderate Alcohol Consumption And Inflammation On The Hepatic Matrisome And The Renal Cortex Proteome., Christine E. Dolin May 2017

The Effects Of Moderate Alcohol Consumption And Inflammation On The Hepatic Matrisome And The Renal Cortex Proteome., Christine E. Dolin

Electronic Theses and Dissertations

Background. The association of chronic ethanol (EtOH) consumption with extracellular matrix (ECM) changes in alcoholic liver disease (ALD) is well established in the context of hepatic fibrosis. However, it is becoming increasingly understood that the hepatic ECM responds dynamically to stress well before fibrosis. The term “transitional tissue remodeling” describes qualitative and quantitative ECM changes in response to injury that do not alter the overall architecture of the organ; these ECM changes may contribute to early disease initiation and/or progression. The nature and magnitude of these changes to the ECM are currently poorly understood. In contrast to the liver, EtOH …

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Using A Multi Variate Pattern Analysis (Mvpa) Approach To Decode Fmri Responses To Fear And Anxiety., Sajjad Torabian Esfahani May 2017

Using A Multi Variate Pattern Analysis (Mvpa) Approach To Decode Fmri Responses To Fear And Anxiety., Sajjad Torabian Esfahani

Electronic Theses and Dissertations

This study analyzed fMRI responses to fear and anxiety using a Multi Variate Pattern Analysis (MVPA) approach. Compared to conventional univariate methods which only represent regions of activation, MVPA provides us with more detailed patterns of voxels. We successfully found different patterns for fear and anxiety through separate classification attempts in each subject’s representational space. Further, we transformed all the individual models into a standard space to do group analysis. Results showed that subjects share a more common fear response. Also, the amygdala and hippocampus areas are more important for differentiating fear than anxiety.

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Trunk And Respiratory Motor Control In Typically Developing Children And Its Implications In Children With Chronic Spinal Cord Injury., Goutam Singh May 2017

Trunk And Respiratory Motor Control In Typically Developing Children And Its Implications In Children With Chronic Spinal Cord Injury., Goutam Singh

Electronic Theses and Dissertations

Independent sitting is a major milestone and is also a prerequisite for optimal performance of activities of daily living (ADLs). Development of sitting posture control is a dynamic process involving control of degrees of freedom of head and trunk. Traditionally, trunk has been modeled as a single unit (segment). However, recent studies have suggested that it is made up multiple spinal units, controlled by a combination of trunk muscles. During typical development, posture control of trunk is different for different trunk segments. This motor development of trunk control is a complex process due to constant interaction between the nervous system …

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Evaluating The Impact Of Statewide Policy Implementation On Interorganizational Collaboration At The Regional Level : An Application Of Network Analysis., Nida Moez Ali May 2017

Evaluating The Impact Of Statewide Policy Implementation On Interorganizational Collaboration At The Regional Level : An Application Of Network Analysis., Nida Moez Ali

Electronic Theses and Dissertations

One challenge to improving population health in the United States is that the systems tasked with the responsibility of providing services across the continuum of care often operate in silos, missing opportunities to provide quality, coordinated care. In 2011, Texas received approval from the Centers for Medicare and Medicaid Services (CMS) for a five-year 1115(a) Medicaid Waiver Demonstration Project. This dissertation focuses on one element of the Waiver, the Delivery System Reform Incentive Payment (DSRIP) Program, which was designed to incentivize activities that support organizations’ collaborative efforts with other organizations in addressing the Triple Aim strategies. DSRIP was implemented through …

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Tonal Shift, Cadence And Transition In The Brass Sonatas Of Paul Hindemith., Blake Taylor May 2017

Tonal Shift, Cadence And Transition In The Brass Sonatas Of Paul Hindemith., Blake Taylor

Electronic Theses and Dissertations

This thesis examines analytical facets in Paul Hindemith’s sonatas for brass and piano, ranging in date of composition from 1938 to 1955, while also considering Hindemith’s role as a neoclassicist and how these works help inform and shape our knowledge of Hindemith’s neoclassicism. The document is divided into four chapters: Hindemith and Tonality, Analytical Concerns and Methods, Brass Sonata Analyses, and Hindemith and Neoclassicism. As a fundamentally neoclassical composer, Hindemith combined traditional aspects of form with new applications of tonality, establishing within his music various levels of what he termed “key areas.” Through analyzing the corpus of sonatas for solo …

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The Association Between Motor Proficiency, Cognitive Tempo, Academic Skills, Balance And Visual Efficiency In Elementary School Aged Children., Franklin R. Muntis May 2017

The Association Between Motor Proficiency, Cognitive Tempo, Academic Skills, Balance And Visual Efficiency In Elementary School Aged Children., Franklin R. Muntis

Electronic Theses and Dissertations

The purpose of this study was to investigate the association between motor proficiency, cognitive tempo, academic skills, balance and visual efficiency in elementary school aged children at a local Spanish immersion school. Forty-nine students and their parents provided consent to participate in the study. Motor proficiency was measured using the Bruininks-Oseretsky Test of Motor Proficiency Second Edition (BOT-2), cognitive tempo and academic skills were assessed using the Child and Adolescent Behavior Inventory, Visual Efficiency was measured using Visual Efficiency Rating (VERA) and Balance was measured using a Neurocom® platform function for stability evaluation test to determine limits of stability. …

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Man/Boy., Nick Hartman May 2017

Man/Boy., Nick Hartman

Electronic Theses and Dissertations

Verisimilitude, or the appearance of being true, is a concept I turn upside down; relating it to a guise I wear as a contemporary male in a society dictated by learned social behavior and gender norms. Cultural iconography and expected gender norms are tropes I confront within my artwork. Drawings of seemingly everyday objects act as meditations or a fetishized repetition of supposed unobtainable objects and ideals that deal with masculine societal norms. Manliness, machismo, masculinity… it is all a culturally learned and expected pose placed on all men. Coming to the realization that I do not necessarily fit …

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Targeting The Glucose Metabolism Of Myeloid-Derived Suppressor Cells (Mdscs) To Stimulate Cancer Immunity., Jaspreet Grewal May 2017

Targeting The Glucose Metabolism Of Myeloid-Derived Suppressor Cells (Mdscs) To Stimulate Cancer Immunity., Jaspreet Grewal

Electronic Theses and Dissertations

Myeloid derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells that are significantly increased in cancer patients and correlate with higher stage and poor prognosis. MDSCs negatively modulate anti-tumor immunity, suppress T cell activity, promote angiogenesis and increase the risk of metastasis. In this study, we report that monocytic-MDSCs (M-MDSCs) but polymorphonuclear-MDSCs (PMN-MDSCs) over-express 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatases 3 (PFKFB3), an important regulator of glycolysis. Furthermore in the melanoma model, M-MDSCs but not PMN-MDSCs suppressed T cell function which correlated with PFKFB3 over-expression and increased rate of glycolysis. PFKFB3 inhibition with the first-in-class small molecule inhibitor, PFK-158 reversed M-MDSC …

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Unthink Pink : Master Narratives And Counterstories Of Breast Cancer., Jessica C. Hume May 2017

Unthink Pink : Master Narratives And Counterstories Of Breast Cancer., Jessica C. Hume

Electronic Theses and Dissertations

This work examines the construction and impact of the master narrative breast cancer which is supported and reified by the contemporary breast cancer awareness movement. I contend that historical problematic constructions of the female body were interwoven with the beginning of the movement around the turn of the twentieth century. As a partial result, the female body with breast cancer is abject, and therefore subject to policing and discipline. The master narrative of breast cancer, through pinkwashing, enacts this policing and discipline. The master narrative expresses several distinct messages which may be exclusive of the experiences of many people, causing …

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The Sounds Behind Language : Three Musical Settings Of Beckett's Not I By Heinz Holliger, Paul Rhys, And Agata Zubel., Trevor Roy Dejarnett May 2017

The Sounds Behind Language : Three Musical Settings Of Beckett's Not I By Heinz Holliger, Paul Rhys, And Agata Zubel., Trevor Roy Dejarnett

Electronic Theses and Dissertations

Samuel Beckett’s literary and dramatic works have served as sources of inspiration in the last five decades for multiple composers such as Morton Feldman and György Kurtág. Beckett’s late minimalist monologue Not I (1972) is the basis for recent compositions by Heinz Holliger, Paul Rhys, and Agata Zubel. While scholars have discussed similarities between Beckett’s style and individual musical works, a comprehensive study of multiple compositions based on the same work by Samuel Beckett has not yet been completed. Each of these compositions reflects various aspects of Beckett’s late dramatic style such as his use of rhythm, depiction of internal …

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Embeddedness And Commitment : Tracing Patterns Of Family Instability And Child Wellbeing Over Time., Heidi Michele Williams May 2017

Embeddedness And Commitment : Tracing Patterns Of Family Instability And Child Wellbeing Over Time., Heidi Michele Williams

Electronic Theses and Dissertations

This dissertation includes three quantitative papers using data from the Fragile Families and Child Wellbeing Study. Paper one, “For us or the children: Exploring the association between coparenting trajectories and parental commitment,” is situated in commitment theory and estimates latent growth curves. Findings suggest that unmarried parents’ coparental relationships are: 1) strong across the first five years of their children’s lives, and 2) influencing parental commitment at year 5. Paper two, “Maternal partnership transitions and coresidence with extended kin,” is situated in life course theory and estimates fixed and random effects models. Findings suggest that unmarried versus married mothers …

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Fantastical Body Narratives : Cosplay, Performance, And Gender Diversity., Tiffany M. Hutabarat-Nelson May 2017

Fantastical Body Narratives : Cosplay, Performance, And Gender Diversity., Tiffany M. Hutabarat-Nelson

Electronic Theses and Dissertations

This dissertation aims to explore how the phenomenon of cosplay has been able to produce and sustain a diversity of gender expression due to its emergence from an activity-based community that emphasizes creative play. This creative energy is manifested through cosplay as an active, ritualized practice in which gender diversity is invited to be realized as a distinct possibility, resulting in a display of a full range of masculinities and femininities as well as crossplays and genderbend cosplays. I argue that cosplay can therefore be understood as a phenomenon that destabilizes the gender binary—its active practice promotes the production and …

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Remotely Sensed Heat : Variation And Change In Surface Urban Heat Islands In A Temperate Eco-Region Of The United States., Jeremy Sandifer May 2017

Remotely Sensed Heat : Variation And Change In Surface Urban Heat Islands In A Temperate Eco-Region Of The United States., Jeremy Sandifer

Electronic Theses and Dissertations

Urban heat island (UHI) is a term used to describe increased surface and atmospheric temperatures in an urban core relative to surrounding non-urbanized areas. To examine the variability introduced into derived estimates of the surface UHI, this study constructs and compares multiple remotely sensed indicators of the surface UHI for major metropolitan cities of a temperate eco-region of the United States. The Moderate Resolution Imaging Spectroradiometer (MODIS) 8-day, 500-meter product (MOD11A2) is the source data used to calculate six different RS-derived UHI indicators for the year 2002 to 2012. The different SUHI indicators are evaluated using the Spearmans Rho rank-order …

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Parental Opinions About Prenatal Genetic Screening And Selective Abortion For Down Syndrome., Laura E. Holt May 2017

Parental Opinions About Prenatal Genetic Screening And Selective Abortion For Down Syndrome., Laura E. Holt

Electronic Theses and Dissertations

Recent advancements in the field of genetic testing have made it easier to prenatally identify the presence of Down Syndrome in a fetus. The purpose of this study was to examine the opinions of parents who are currently raising a child with Down Syndrome towards genetic screening and selective abortion for the condition, as well as any potential effects of this process on their families. A series of individual interviews with twenty parents was conducted. An inductive methodology was used to analyze interview data. The key findings indicate that parents’ perspectives of the role of the physician in the genetic …

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A Fly Has Died A Splendid Death In A Pool Of Strawberry Ice Cream., Miranda L. Becht May 2017

A Fly Has Died A Splendid Death In A Pool Of Strawberry Ice Cream., Miranda L. Becht

Electronic Theses and Dissertations

Humans have evolved an overwhelming awareness of self, other, life, and death. We have learned to selectively process information and to replace dissociated memories with less disturbing ones. We have evolved this ability to deceive ourselves, thus producing a personal reality that is innately false. As a society we tend to idealize our vision of the past, particularly our vision of home. Our idealized notion of home presents itself as a supposedly traditional form of domestic life, but bears little relation to the way people actually lived. This concept of a cozy home full of family love is an invented …

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Breaking The Cycle Of Silence : The Significance Of Anya Seton's Historical Fiction., Lindsey Marie Okoroafo (Jesnek) May 2017

Breaking The Cycle Of Silence : The Significance Of Anya Seton's Historical Fiction., Lindsey Marie Okoroafo (Jesnek)

Electronic Theses and Dissertations

This dissertation examines the feminist significance of Anya Seton’s historical novels, My Theodosia (1941), Katherine (1954), and The Winthrop Woman (1958). The two main goals of this project are to 1.) identify and explain the reasons why Seton’s historical novels have not received the scholarly attention they are due, and 2.) to call attention to the ways in which My Theodosia, Katherine, and The Winthrop Woman offer important feminist interventions to patriarchal social order. Ultimately, I argue that My Theodosia, Katherine, and The Winthrop Woman deserve more scholarly attention because they are significant contributions to women’s …

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Non-Contact Based Structural Damage Assessment Using Stochastic Subspace Identification And Finite Element Model Updating., Li Yang May 2017

Non-Contact Based Structural Damage Assessment Using Stochastic Subspace Identification And Finite Element Model Updating., Li Yang

Electronic Theses and Dissertations

This research proposed and verified an innovative method to identify and locate structural damage using only the response of operational vibration, that is the displacement acquired by a non-contact optical method. The most efficient and economical way to detect damage within the structure is to monitor its structural health while in operation. However, the uncertainties and the randomness of ambient vibrations due to the operation and environments cause a challenge in conducting the operational analysis. Current technology limits the ability to collect data on the properties of the structure without the interruption of operation. Frequencies and mode shapes have been …

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Stories At Work : Restorying Narratives Of New Teachers' Identity Learning In Writing Studies., Rachel Gramer May 2017

Stories At Work : Restorying Narratives Of New Teachers' Identity Learning In Writing Studies., Rachel Gramer

Electronic Theses and Dissertations

Rhetoric and composition has a long, robust history of studying how we train new writing teachers in our graduate/writing programs; yet we lack in-depth inquiries that foreground how new writing teachers learn. This dissertation traces five graduate students learning how to be and become writing teachers, using narrative as an object and means of analysis to study the tacitly internalized process of newcomer professional identity learning. In this project, I enact narrative as a feminist, interdisciplinary methodology to restory new writing teacher research narratives away from implicit deficit or explicit resistance and toward a more generative focus on newcomers’ motivated …

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An Analysis Of The Relationship Between Snowpack And Groundwater Across Utah Watersheds., Samuel Wright May 2017

An Analysis Of The Relationship Between Snowpack And Groundwater Across Utah Watersheds., Samuel Wright

Electronic Theses and Dissertations

This thesis examined what type of relationship existed between snow water equivalence (SWE) volume and groundwater elevation within six sub-watersheds in Utah. Data was gathered on SWE from seventeen SNOTEL sites and groundwater elevation data was gathered from six continuously monitored groundwater wells. This data was gathered for January through May for 2011, 2013, and 2014 in order to represent the water conditions that were above average, below average, and average respectively. Using MLR formulas the total SWE for each sub-watershed was determined for each year/month. Afterwards a correlation analysis was performed to determine if any association existed between SWE …

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Ironic Deference : An Inquiry Into The Nineteenth-Century Feminist Rhetoric Of Kesiah Shelton., Melissa Rothman May 2017

Ironic Deference : An Inquiry Into The Nineteenth-Century Feminist Rhetoric Of Kesiah Shelton., Melissa Rothman

Electronic Theses and Dissertations

This project examines the works of Kesiah Shelton, a writer for popular magazines in the late nineteenth century who used irony in interesting ways to critique the social norms of the period. Although, scholars have noted that female authorship was a an expanding field during this period, there were very specific gendered expectations limiting what female authors wrote about; women were primarily limited to writing about domestic matters and were discouraged from taking up other topics associated with the male public sphere such as politics. Many scholars have noted how the cult of domesticity valorized women as superior moral beings, …

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Moral Time And Homicide Investigations., David Stuart Lapsey Jr. May 2017

Moral Time And Homicide Investigations., David Stuart Lapsey Jr.

Electronic Theses and Dissertations

Previous literature explores the many dimensions of homicide investigations, including case and individual characteristics, evidence and investigative activities. However, little research delves into situational characteristics and their relationship to specific homicides, charge severity sought by prosecutors and sentence length given to homicide offenders. The current study sampled homicide cases (N=68) to gather baseline information and data regarding judicial outcomes. Donald Black’s Theory of Moral Time (2011) is tested and utilized as the study’s conceptual framework for the study’s hypotheses.

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Retellings : A Collection Of Nonfiction Essays., Jennifer Kiefer May 2017

Retellings : A Collection Of Nonfiction Essays., Jennifer Kiefer

Electronic Theses and Dissertations

This thesis is a collection of nonfiction essays, extending both into the realms of journalism as well as into more traditional creative nonfiction essays. While each piece is based in true stories, each piece has its own style. As such, this collection is an exploration of different forms of and takes on the nonfiction essay. It is divided into four chapters, one for each essay. The first half encompasses journalistic pieces previously published in Louisville Magazine, one in the August 2016 issue and one in the February 2017 issue. The first piece is a literal retelling of three medical stories, …

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