Digital Commons Network^™

The Applications And Implications Of A (Re)Humanizing Praxis For Early Childhood Educational Contexts, Kristopher M. Tetzlaff

Electronic Theses and Dissertations

Dehumanizing preschool policies and practices and a lack of access to affordable, (re)humanizing early childhood educative experiences threatens to exacerbate the opportunity gap and deleterious preschool-to-prison pipeline. The purpose of this study was threefold; foremost, it aspired to elevate the role and power of critical resource pedagogies in individual and collective liberation. Second, it aimed to identify vital pedagogical and programmatic assets that advance the pursuit of mutual humanization in early childhood educational settings. Third, it sought to discern and address the pedagogical and programmatic limitations and systemic barriers that otherwise impede access to high quality early childhood programming. In …

Statistical Modeling Of Knee Morphology And Material Properties Considering Diverse Populations, Gabrielle Jeannine Kindy

Electronic Theses and Dissertations

Total Knee Arthroplasty (TKA) is a widely performed surgical procedure aimed at alleviating pain and restoring function in patients with severe knee osteoarthritis. Despite its general success, disparities in postoperative outcomes have been observed across different racial and ethnic groups, with minority populations often experiencing less favorable results. One potential avenue for improving the generalizability of orthopaedic implants is using Statistical Shape and Intensity Models (SSIMs), which can be used to incorporate patient variability directly into the orthopaedic medical device development workflow through population-based finite element analysis.

This work aimed to construct an SSIM from a diverse subject set, incorporating …

The Aquatic Microbial Environment Shapes The Gut Microbiota, Brain, And Behavior Of Larval Amphibians, Kyle Emerson

Electronic Theses and Dissertations

Microbial communities comprising bacteria, viruses, fungi, and protists live within and on the surfaces of animal hosts. These microbial communities exist in symbiosis with the host, and heavily influence host physiology, development, health, and fitness. Gut-dwelling microbes (i.e., gut microbiota) contribute to host neurodevelopment through a bidirectional Microbiota-Gut-Brain (MGB) axis. Evidence of the MGB axis has been primarily derived from studies that use germ-free (GF) models, which commonly display altered neurophysiology and behavior compared to conventionally raised counterparts. Almost all studies of the MGB axis have used mammalian models in a biomedical framework, leaving a knowledge gap regarding the role …

Using Self-Assessment Tools And Complementary Alternative Therapy For Chronic Migraines In Menopausal Women, Krystal Rachelle Bridwell

Electronic Theses and Dissertations

Abstract

Migraine headaches are ranked as one of the highest disabling conditions in the United States. Women who are in the perimenopausal transition phase have a higher prevalence of disabling migraines that can result in a decreased quality of life, loss of income, decreased productivity, and a higher risk for emotional difficulties. The gap in practice is the lack of education on complementary alternative medicine (CAM) and the use of a migraine diary to recognize individual symptoms as a substitute or cotherapy with pharmacologic treatments. The purpose of this scholarly project was to improve clinical practice and outcomes for perimenopausal …

Stimuli-Responsive Glycopolymeric Nanoparticles To Boost Tumor Immunogenicity Through Macrophage-Targeted Therapy, Oluwaseyi Shofolawe-Bakare

Electronic Theses and Dissertations

Tumor-associated macrophages (TAMs) play a substantial role in sculpting the tumor microenvironment (TME) into an immunosuppressive bastion that undermines immune surveillance and enables tumor progression. They therefore represent a promising therapeutic target to make the TME more conducive for anti-tumor immunity and greatly improve treatment outcomes in cancers that are highly resistant to conventional forms of therapy. Several medications have been developed to modulate the activities of TAMs, showing tremendous potential, but these medications lack specificity for TAMs making their use susceptible to adverse side effects that could outweigh prospective benefits. Sophisticated delivery vehicles that can preferentially deliver these medications …

A Narrative Inquiry Into Contingent Music Faculty Experiences, Herbert Midgley

Electronic Theses and Dissertations

The increasing reliance on short-term or contingent faculty reflects a shift away from tenure-track positions. Tenure-track faculty reduction is significant in academic disciplines such as music. This qualitative narrative inquiry study explored the professional experiences of contingent music faculty through semi-structured interviews. Narrative inquiry allows for individual participant voice in which this study examined participant relationships with faculty colleagues, employment experiences at higher education institutions, and working conditions. Implications of this study include new ways of understanding support structures from colleagues and institutions for contingent music faculty members, deeper perspective about the current state of teaching at their universities, and …

Omani Camels From A Cultural And Genomics Perspective, Al Muatasim Al Zadjali

Electronic Theses and Dissertations

The Dromedarian camel, Camelus dromedarius, is native to the Arabian Peninsula, including the Sultanate of Oman. These camels are used for food, milk, as well as show and racing competitions. Despite their economic and cultural importance research on camels in Oman is limited. The goal of this study was to examine their genomic variation, relationship with camels in other parts of the Arabian Peninsula, and to determine if selective breeding has led to the establishment of distinct breeds in Oman. Information was compiled from multiple sources to produce a comprehensive review on the breeding, management, economic and cultural use, …

Evaluation Of Changes In Evaporative Losses From Lake Powell Reservoir Contributions In The Colorado River Basin, Maria Mlinarcik

Electronic Theses and Dissertations

The Colorado River Basin (CRB) is one of the most critical water sources for the western United States (U.S.) and Mexico. For over a century, numerous policies and regulations have been implemented in attempts to manage the Colorado River Basin to address the concern of overuse, collectively referred to as the “Law of the River.” The USGS hydrologist E.C. LaRue warned that the optimistic estimates used in negotiating the Colorado River Compact did not align with the actual water availability in the river. His analysis in 1925 revealed a potential deficit if all allocated water was utilized, exacerbated by overallocation …

Relationships Between Students’ Ict Usage, Self-Efficacy And Literacy, Malimi Kazi

Electronic Theses and Dissertations

Information and communication technology (ICT) usage, self-efficacy, and literacy are very important for people in the 21st century. People need them to participate successfully in various activities including learning and working. Because of the importance of ICT, nations around the world, including the United States, have developed and are implementing ICT policies. Also, in 2013 the International Association for the Evaluation of Educational Achievement (IEA) introduced the International Computer and Information Literacy Study (ICILS) for grade eight students. However, ICT usage, ICT self-efficacy, and ICT literacy can be affected by students’ gender, race and socioeconomic status (SES). The purpose of …

Surface Water Quality Assessment Of Mingo Creek County Park: The Impacts Of Extractive Industries, Mikayla J. Bayto

Electronic Theses and Dissertations

Historical and current extraction operations and infrastructure, including natural gas pipelines, conventional and unconventional oil and natural gas drilling, longwall coal mining, and strip coal mining, occur throughout the Mingo Creek watershed of Washington County, Pennsylvania, including Mingo Creek County Park. Mingo Creek and several associated tributaries flow through Mingo Creek County Park, eventually discharging into the Monongahela River. An independent water quality study was conducted from June 2020 through July 2023 in Mingo Creek County Park to determine if historical and current extraction activities impact Mingo Creek and its associated tributaries. Weekly sampling of Mingo Creek and associated tributaries …

The Ethical Justification Of Medical Interventions Across The Spectrum Of Healthcare For Patients Preceding The Age Of Consent: The Tension Between Surrogate Consent And Minor Assent, Erin Scroggins

Electronic Theses and Dissertations

This dissertation, The Ethical Justification of Medical Interventions Across the Spectrum of Healthcare for Patients Preceding the Age of Consent: the Tension Between Surrogate Consent and Minor Assent, will aim to provide ethical justification for medical intervention for patients preceding the age of consent. To begin, decision-making for medical intervention in all forms will be examined. Followed by, beginning of life interventions into complex and controversial situations for medical intervention which then leads into end-of-life considerations for patients preceding the age of consent. These chapters will pose various ethical considerations for some more contentious dilemmas. It has been pondered …

Impact Of Glycerophosphocholine Metabolism On Phenotypes In Saccharomyces Cerevisiae And Schizosaccharomyces Pombe, Victoria Hrach

Electronic Theses and Dissertations

Glycerophosphocholine (GPC) is an abundant metabolite in eukaryotes. In baker’s yeast, Saccharomyces cerevisiae, GPC can be produced via deacylation of the major membrane glycerophospholipid phosphatidylcholine (PC). My lab has identified a novel pathway to re-synthesize PC from GPC by acylating it at the sn-1 and sn-2 positions; this pathway has been termed the PC Deacylation-Reacylation Pathway (PC-DRP). We previously characterized the acyltransferase Gpc1 and its ability to synthesize one-tailed lyso-PC from GPC, as well as that noting that GPC1 is upregulated in inositol-free conditions and results in more saturated PC. Here, I add to this basic characterization by establishing …

Characterization Of A Novel Metalloid Reductase Outer Membrane Porin Rara From Sulfurospirillum Barnesii Ses-3, Narthana Jeganathar Kanmanii

Electronic Theses and Dissertations

Sulfurospirillum barnesii SES-3 is a gram-negative epsilon proteobacterium that grows anaerobically by coupling the oxidation of lactate to the reduction of arsenate. Previous work on metal and metalloid metabolism in S. barnesii had identified a redox active protein, designated RarA that when provided an artificial electron donor (i.e., reduced methyl viologen, FMN, or NADH), could reduce a variety of substrates, including arsenate, selenate, selenite, nitrite, and even phosphate. The enzyme’s inferred amino acid sequence showed weak similarity (30%) to outer membrane porins with homologs found in only certain species of Sulfurospirillum. Further, the enzyme did not contain cysteine residues …

Comparative Functional And Computational Analyses Of Primate Seminal Proteins: Insights Into Sexual Selection And Hiv/Siv, Emine Feride Kahveci

Electronic Theses and Dissertations

Male reproductive protein-coding genes are among the most rapidly evolving genes across many animal taxa, commonly attributed to sexual selection; however, pathogen defense mechanisms might also be contributing factors. This study aimed to both computationally and experimentally investigate the selective pressures responsible for the rapid evolution of seminal proteins. In the first part, the research focused on sexual selection in the form of post-copulatory sperm competition as a driving force behind the evolution of kallikrein related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), a key prostatic seminal protein. KLK3 is responsible for the liquefaction of semen coagulum through …

Quaternary Diamond-Like Sulfides For Nonlinear Optical Applications: Investigation Into Composition-Structure-Property Relationships Of The I2-Ii-Iv-Vi4 And I4-Ii-Iv2-Vi7 Formulae, Jordan Kelly

Electronic Theses and Dissertations

The research work presented in this dissertation focuses on the synthesis, characterization, and property assessment of new and existing quaternary diamond-like semiconductor (DLS) materials for the potential application in infrared (IR) nonlinear optics (NLO). Chapter 2 discusses the previously discovered temperature-dependent polymorphs of Cu₂ZnGeS₄ (CZGS); however, the IR NLO properties, neutron powder diffraction data, and single crystal X-ray diffraction structures were previously undetermined. The high-temperature α-CZGS polymorph was superior to the low-temperature β-CZGS analog in both second harmonic generation (SHG) and laser-induced damage threshold (LIDT). Chapter 3 presents the discovery of Li₂MgGeS₄ and comparison …

Targeting Cancer- One Carbon At A Time: Design And Synthesis Of Pyrimidine Based Heterocycles As Potential Cancer Chemotherapeutics, Md Junayed Nayeen

Electronic Theses and Dissertations

With over 6 million death counts, cancer is the second leading cause of death in the United States. Lung cancer was the leading cause of cancer death, accounting for 23% (136,084 death count) of all cancer deaths. Other than that, colon and rectal (9%, 51,869 death count), pancreas (8%, 46,774 death count), female breast (7%, 42,275 death count), prostate (5%, 32,707 death count), and liver and intrahepatic bile duct (5%, 28,227 death count). Other cancers individually accounted for less than 5% of cancer deaths. Although cancer death rates decreased about 27% from 2001 to 2020, the therapeutic options are limited …

Development Of A Rapid Bacterial Quantification Method Based On Droplet Microfluidics, Shawn Bliss

Electronic Theses and Dissertations

The capacity to identify bacteria quickly and accurately is critical for applications such as medical diagnosis, environmental monitoring, and food safety. For instance, sepsis diagnosis requires blood cultures that take as long as 1-5 days, preventing timely intervention and increasing mortality rate. Here, we propose the joint use of microfluidics and a machine learning algorithm for rapid bacterial cell capture and quantification. The combination of high-throughput droplet microfluidics and a support vector machine (SVM) enables analysis and quantification of bacterial samples within as short as 4 hours. We have performed successful encapsulation of pathogenic bacteria such as E. coli, …

An Analysis Of The Logging Sector In East Texas: Current Status And Future Prospects, Pooja Chhetri

Electronic Theses and Dissertations

The logging sector plays a critical role in the wood supply chain and in forest management. It connects forest resources with mills, who consequently use that wood to manufacture a multitude of products. A better understanding of the state of logging businesses among policymakers is crucial in sustaining this industry. Therefore, this study aimed to estimate the economic contribution (2021) and economic contribution trend (2012-2021) of the logging sector in East Texas using Impact Analysis for Planning (IMPLAN). Furthermore, this study determined the current status of this sector using online and mail surveys. IMPLAN results showed that the logging sector …

The Distinctive Contribution Of The Catholic Tradition On Emerging Ethical Issues Around Embryos., Michael Donkor

Electronic Theses and Dissertations

This dissertation considered the distinctive contribution of the Catholic Church surrounding emerging ethical issues around embryos. In many Catholic doctrines, the church has stated that the embryo must be treated as if it were a human person with (soul) and must be protected. The embryo is considered an individual with relational qualities worthy of all the rights given all humans per the natural law.

The Church continues to oppose all forms of assisted reproduction that eliminates the unitive and procreative nature of marriage as it violates the dignity of the child and marriage. Technologies such as lower tubal ovum transfer(LTOT), …

The Contributions Of Philosophical Anthropology To Healthcare Ethics, Bura Koroba

Electronic Theses and Dissertations

The first principles of bioethics, autonomy, beneficence, nonmaleficence, and justice have contributed immensely to healthcare ethics. The procedural approach streamlines the decision-making process, protects vulnerable subjects, and fosters stability and trust in the patient-caregiver relationship. Yet, the principles are demonstrably insufficient, riddled with limitations and loopholes that could stand in the way of care.[i] Several recommendations have been proffered to remedy the deficiencies. Value ethics, for instance, has been touted as a proficient addendum to the foundations established by the principles. Still, these have not sufficiently addressed all arising issues in bioethics. Besides the challenges encountered in decision-making, opposing …

A Critique Of The Pivotal Ethical Issues In Organ/Tissue Donation & Transplantation, Francis Sarpong

Electronic Theses and Dissertations

Organ or tissue donation has proven to be a lifesaving intervention for patients battling failing or failed organs or tissues. However, scholars have raised concerns about just and rational procurement and transplantation in a global shortage. This dissertation addresses normative approaches for organ/tissue procurement, allocation and transplantation to highlight the related pivotal ethical issues. It defends normative approaches such as queuing and nudging, and upholds their universal obligatoriness. It provides illumination about the demands of an effective solution to who shall receive or give organs when not all can. The introductory chapter employs common morality as a principal source of …

Assessing Sustainability Within The Brewing Industry: A Literature Review And Benchmarking Analysis., Elijah Thomas Miller

Electronic Theses and Dissertations

The goals of this study were twofold: to further examine sustainability within the brewing industry through a literature analysis across four academic journals, and a benchmarking analysis of a Louisville, Kentucky brewery’s resource consumption and emissions production. Publications related to the brewing industry were examined for the presence of sustainability keywords: “efficiency, sustainability, carbon footprint, climate change and greenhouse gas”. Benchmarking examined the local brewery’s primary production facility to determine their performance compared to other surveyed breweries pursuing sustainability across the country. Literature examination found noticeable discrepancies between the appearance of sustainability topics within article abstracts and their discussion within …

Ligand-Stabilized Sno2 As A High-Performance And Scalable Electron Transport Material For Inverted Perovskite Solar Cells., Sashil Chapagain

Electronic Theses and Dissertations

Over the past decade, perovskite solar cell (PSC) technology has attracted significant attention for its low material costs, simple fabrication processes, and impressive photovoltaic performance, with recent power conversion efficiencies (PCEs) surpassing 26%. This advancement marks PSCs as strong competitors to traditional silicon-based photovoltaics. Despite the high efficiency of PSCs, the path to commercialization is hindered by challenges in stability, scalability, and module efficiency. The stability and scalability of PSCs are primarily dependent on the successive charge transfer layers (CTLs) that are interfaced with the perovskite layer. Among CTLs, metal oxide (MO_x) CTLs are preferred for their cost-effectiveness, …

Cybersecurity Education Praxis And Broadening Participation In Cybersecurity: Pieces Of The Same Puzzle., Cynthia N. Thomas

Electronic Theses and Dissertations

This dissertation study examined cybersecurity education praxis and broadening participation in cybersecurity in response to calls of action made by the government-funded National Science Foundation. The cybersecurity education domain has a literature base investigating pedagogical practices that foster cybersecurity learning. However, a gap in the literature is reports of cybersecurity learner perceptions regarding implemented pedagogical practices. Authentic research centering on the experiences of the marginalized and underrepresented identity holders targeted in broadening participation calls is also limited in the cybersecurity education research domain. As such, this study is positioned as a response to the traditionally compartmentalized approaches of praxis and …

Investigation Of Avaren-Fc's Therapeutic Potential Against Ovarian Cancer., Katarina Lee Mayer

Electronic Theses and Dissertations

This thesis describes the investigation of Avaren-Fc (AvFc), a novel lectin-based therapeutic fusion protein consisting of the recombinant Avaren lectin and the Fc region of human IgG1, against ovarian cancer. AvFc possesses selectivity toward tumor associated N-linked high-mannose-type glycans. The present study demonstrates AvFc’s in vitro activity against OVCA cell lines via antibody-dependent cell-mediated cytotoxicity and its ability to extend the survival of mice challenged with murine ID8 OVCA cells after repeated systemic administration. Furthermore, AvFc treatment in this model was found to increase the presence of peritoneal leukocytes, suggesting a shift toward an improved antitumor immune response. Another key …

The Impersonation Artist: A Novel With Critical Afterword: Displacement And Dissent In Fiction And Art., Flora K. Schildknecht

Electronic Theses and Dissertations

This dissertation consists of a creative project, The Impersonation Artist: A Novel, and a critical afterword, “Displacement and Dissent in Fiction and Art.” On a narrative level, The Impersonation Artist engages the question of how, and if, participatory art can reveal and intervene in oppressive conditions. The novel employs a stylistic methodology in which the use of multiple narrators and narrative fragmentation formally gestures toward the complex dilemma of how artists might intervene in contemporary problems in the face of conflicting ideologies and ever increasing precarity. The novel follows three characters: an environmental activist; a young man veering towards …

Preserving Archaeology In The Digital Age: Evaluating Strategies For Effective Curation And Database Management., Cenetria Leshun Crockett

Electronic Theses and Dissertations

The “curation crisis” is a dark cloud that consistently looms over the archaeological discipline, affecting the ways we plan, execute, and curate research projects. It is especially prominent within curation facilities and institutions that have the duty to preserve archaeological collections. The development of digital curation presents an avenue through which curators and collection managers can combat the crisis. Digital curation grants collection managers the ability to manage and ensure archaeological collection accessibility. Digital collection databases, particularly, have grown to become a significant component of collection management as it permits collections to be easily preserved, managed, saved, and accessible at …

Electrochemical Modulation Of Surface Plasmon Wave To Investigate Dna-Based Sensing Platforms And Detection Of Sars-Cov2., Anil Sharma

Electronic Theses and Dissertations

This study offers a thorough comparative analysis of optical and electrical signaling strategies for assessing the electrochemical properties of different redox-labeled DNA-based biosensing platforms. In addition, it illustrates the development of an optical interrogation technique with electrochemical modulation of surface plasmon waves (ECM-SPW) as a route for analyzing and implementing DNA-based hybridization sensors. For those quantitative analyses, we chose a model sensing platform composed of a methylene blue (MB)-modified single-stranded DNA (ssDNA) signaling probe and an unlabeled capture ssDNA probe that complements the signaling probe. Two types of signaling probes were employed in this work: one with MB attached to …

Using Aashe Stars As A Pedagogical Instrument: An Experiential Learning Opportunity In Sustainability Education., Robin Frederick

Electronic Theses and Dissertations

This thesis investigates faculty interest in utilizing the Sustainability Tracking, Assessment & Rating System (STARS) as an educational tool within higher education curricula. In recent years, there has been a noticeable uptick in the availability of sustainability courses and programs within higher education. The STARS framework evaluates the quantity and diversity of these offerings across universities. Employing a mixed-method approach, a literature review was conducted, and a survey was disseminated to United States universities to gauge barriers and interest in incorporating STARS within the classroom. Results demonstrate that faculty at institutions with regular STARS submissions show considerable interest, ranging from …

Acoustofluidic Delivery Of Biomolecules To Cells: A Novel Approach For Preparing Car-T Cells., Madison C. Colebank

Electronic Theses and Dissertations

The continuous pursuit of effective methods for gene transfection in primary human T cells is crucial for advancing cell-based therapies. Viral vectors, currently used in cell-based therapies, involve a lengthy and costly process. This thesis explores the efficacy of coupling acoustofluidic and sonoporation techniques as an alternative non-viral gene transfection approach with primary T cells. Sonoporation, in conjunction with microbubbles, has been demonstrated to induce cavitation, resulting in the formation of pores in the cell membrane through which molecules can enter. Using flow cytometry, we compared the loading efficiency of primary T cells with that of Jurkat T cells to …