Digital Commons Network^™

Data Linkage For Crash-Injury Outcome Assessment., Aryan Hosseinzadeh

Electronic Theses and Dissertations

Introduction: Traffic crash reports lack detailed information about emergency medical service (EMS) responses, the injuries, and the associated treatments, limiting the ability of safety analysts to account for that information. Integrating data from other sources can enable a better understanding of the characteristics of serious crashes and further explain variance in injury outcomes. In this thesis, first, a heuristic approach is proposed and implemented to link crash data to EMS run data, patient care reports, and trauma registry data. Next, the method was adapted through larger datasets in a statewide linkage effort. The performance of the heuristic method was compared …

New Debiasing Strategies In Collaborative Filtering Recommender Systems: Modeling User Conformity, Multiple Biases, And Causality., Mariem Boujelbene

Electronic Theses and Dissertations

Recommender Systems are widely used to personalize the user experience in a diverse set of online applications ranging from e-commerce and education to social media and online entertainment. These State of the Art AI systems can suffer from several biases that may occur at different stages of the recommendation life-cycle. For instance, using biased data to train recommendation models may lead to several issues, such as the discrepancy between online and offline evaluation, decreasing the recommendation performance, and hurting the user experience. Bias can occur during the data collection stage where the data inherits the user-item interaction biases, such as …

The Water We Were Swimming In: Transgender And Gender Nonconforming Students' Lived Experiences In Engineering., Natalie Saroff Oliner

Electronic Theses and Dissertations

Few studies address the lived experiences of transgender and gender nonconforming (TGNC) students in engineering. Grounded in critical trans politics (Spade, 2015), this dissertation contributes to the literature on TGNC students in engineering by examining their experiences negotiating their identities while navigating interrelated systems of oppression in a field dominated by White, heterosexual, cisgender men. Using a critical constructivism framework, I conducted a narrative inquiry to explore the lived experiences of five TGNC students in engineering programs. Participants experienced TGNC oppression at their universities, built LGBTQ+ and TGNC communities, and described more welcoming climates in non-engineering contexts compared to engineering. …

Development Of Porous Solid Acid Catalysts For Lignocellulose And Plastic Upcycling., Mohammad Shahinur Rahaman

Electronic Theses and Dissertations

My goal is to develop chemical processes for transforming waste to solve environmental problems and enhance sustainability. Environmental problems such as pollution and massive amounts of waste are the main drivers that stimulate my research ideas. I focused on creating novel, efficient catalytic processes for converting polymeric waste "feedstocks" into high-value chemicals by integrating my expertise in catalysis, materials science, and synthetic chemistry to develop porous solid catalytic materials. During my Ph.D., I focused on two polymeric feedstocks, lignocellulose, and discarded plastic.

Early in my Ph.D. journey, I focused on catalytic upcycling of lignocellulose. Lignocellulosic biomass is cost-effective, abundant, and …

Materials And Interfaces For Electrocatalytic Hydrogen Production And Utilization., Alexander Jiya Gupta

Electronic Theses and Dissertations

Mass industrialization over the last few centuries has created a global economy which is dependent upon fossil fuels to satisfy an exponentially increasing demand for energy. Aside from the possible depletion of this finite resource, the combustion of fossil fuels releases greenhouse gases into the atmosphere which cause the global temperature to rise – a phenomenon which has already begun to create geologic and geopolitical instability and shows no signs of abatement. One proposed method to rid humanity of its dependence on fossil fuels is to use green hydrogen as an energy carrier. In this scheme, excess electricity from a …

Effects Of Sizing Agents On Mechanical Properties Of Carbon Fiber–Polymer Composites Via Fused Filament Fabrication Additive Manufacturing., Benjamin D. Mitchell

Electronic Theses and Dissertations

This study demonstrated the effects of changing the sizing agent parameter during the preparation of carbon fibers on the mechanical properties of composite made with acrylonitrile butadiene styrene (ABS) as the matrix material and carbon fibers as the fiber material. Three types of sizing agents produced by Allnex were used to coat three different batches of carbon fibers that were mixed with a torque rheometer and extruded with a barrel-style melt extruder into continuous spools of 1.75 mm filament for use with commercial 3D printers. Tensile tests were conducted on the filaments and tensile bars printed from the materials. Results …

Release Kinetics Of Metronidazole From 3d Printed Silicone Scaffolds., Sydney E. Herold

Electronic Theses and Dissertations

Sustained local administration of active agents has been proposed to cure bacterial vaginosis in the female reproductive tract and restore the resident bacterial fauna. Bioprinting has shown promise for the development of systems for local agent delivery. In contrast to oral ingestion, agent release kinetics can be fine-tuned by bioprinting specialized scaffold designs tailored for particular treatments while enhancing dosage effectiveness via localized sustained release. It has been challenging to establish scaffold properties for sustained release as a function of fabrication parameters. Towards this goal, we evaluate 3D printed scaffold formulation and feasibility to sustain release of metronidazole, a representative …

Utilizing Shockwave Theory And Deep Learning To Estimate Intersection Traffic Flow And Queue Length Based On Connected Vehicle Data., Abdulmaged Algomaiah

Electronic Theses and Dissertations

The development of Connected Vehicles (CV) facilitates the use of trajectory data to estimate queue length and traffic volume at signalized intersections. The previously proposed models involved additional information that may require conducting different types of data collection. Also, most models need higher market penetration rate or more than a vehicle per cycle to provide adequate estimation. This is mainly because a significant number of the estimation models utilized only queued vehicles. However, the state of motion in non-queued vehicles, particularly slowed-down vehicles, provides much information about the traffic characteristics. There is a lack of exploiting the information from slowed-down …

Kurt Vonnegut, Modernity, And The Self: A Guide To The Good Life., Josh Simpson

Electronic Theses and Dissertations

What are people for? This is a question Kurt Vonnegut raises in his first novel, 1952’s Player Piano. Over five decades later, when he concludes a career with 2005’s A Man Without a Country, he is still asking, “What is life all about?” (66). These are the central questions for Vonnegut, and his novels, short stories, essays, interviews, correspondence, and commencement addresses offer a singular, life-long attempt at an answer. In this dissertation I offer a reading of Vonnegut not just as a writer concerned with philosophical questions, but rather, on a deeper, more personal level, as a …

Surface-Functionalized Chemiresistive Films That Exploit H-Bonding, Cation-Pi, And Metal-Halide Interactions., Prasadanie Karunarathna Adhihetty

Electronic Theses and Dissertations

The development of gas sensors for detection of volatile organic compounds (VOCs) has been of interest in the sensing field for decades. To date, the use of metal nanoparticle-based chemiresistors for trace VOC detection, particularly gold nanoparticle-based sensors, is of great interest due to their high chemical stability, ease of synthesis, unique optical properties, large surface to volume ratio, and high level of conductivity. Much effort has been devoted towards gold monolayer protected clusters (Au MPCs) as chemiresistors to detect harmful VOCs. The present thesis documents the results of our efforts to exploit the advantages of functionalized Au MPCs chemiresistors …

Genomic Tools And Models For Investigating The Role Of Germline Diversity In Mouse Antibody Repertoire Development., Justin T. Kos

Electronic Theses and Dissertations

Given the diversity and complexity within immunoglobulin (IG) loci, effective mouse models first require characterization of intra-strain differences and construction of high-quality reference assemblies for IG loci in several representative strains. To understand light chain germline diversity across biomedically significant mouse strains, we profiled the expressed IGK and IGL repertoires of 18 commonly used laboratory mouse strains using AIRR-seq. Across strains, we observed germline IGKV sequences shared by three different IGK haplotypes and a more conserved IGLV germline repertoire among common laboratory strains. Pacific Biosciences (PacBio) Single-Molecule Real-Time (SMRT) sequencing was used to sequence and assemble bacterial artificial chromosomes (BAC) …

A Modeling Platform To Predict Cancer Survival And Therapy Outcomes Using Tumor Tissue Derived Metabolomics Data., Hunter Allan Miller

Electronic Theses and Dissertations

Cancer is a complex and broad disease that is challenging to treat, partially due to the vast molecular heterogeneity among patients even within the same subtype. Currently, no reliable method exists to determine which potential first-line therapy would be most effective for a specific patient, as randomized clinical trials have concluded that no single regimen may be significantly more effective than others. One ongoing challenge in the field of oncology is the search for personalization of cancer treatment based on patient data. With an interdisciplinary approach, we show that tumor-tissue derived metabolomics data is capable of predicting clinical response to …

Fluid Structure Interactions Within A Common Rail Diesel Injector., Russell Prater

Electronic Theses and Dissertations

The internal flow of a high-pressure diesel injector is simulated numerically to investigate the complex transient flow structures and the unsteady forces imparted to the injector needle that result from the asymmetric flow fields developed during operation. The gas-liquid two phase flow is simulated using a mixture model with the cavitation numerically modeled using the Zwart-Gerber-Belamri model. Both the k-ε model and the detached eddy simulation (DES) model are used, and the numerical results are compared. This dissertation looks at the internal flow of a generic injector at different lifts and characterizes the flow parameters at high lift and low …

(De)Legitimizing Genres: Rhetoric And Tactical Institutional Critique., Walker Smith

Electronic Theses and Dissertations

This dissertation forwards a rhetorical theory of institutions that centers their genre-based communications, redefines institutions in relation to organizations, and contributes to the field’s understanding of how communities collaboratively rewrite entrenched institutionalized practices from the outside, thus reducing the harm that institutions can enact. Using evangelical church policies on marriage as a case study, I answer the following questions: How do historically sedimented institutions, their genres, and their practices rhetorically impose, legitimize, and regulate certain patterns of social life? How does an evangelical Christian church manage to govern the gendered and sexual lives of their members and maintain their power …

Nucleate Boiling Under Different Gravity Values: Numerical Simulations & Data-Driven Techniques., Sandipan Banerjee

Electronic Theses and Dissertations

Nucleate boiling is important in nuclear applications and cooling applications under earth gravity conditions. Under reduced gravity or microgravity environment, it is significant too, especially in space exploration applications. Although multiple studies have been performed on nucleate boiling, the effect of gravity on nucleate boiling is not well understood. This dissertation primarily deals with numerical simulations of nucleate boiling using an adaptive Moment-of-Fluid (MoF) method for a single vapor bubble (water vapor or Perfluoro-n-hexane) in saturated liquid for different gravity levels. Results concerning the growth rate of the bubble, specifically the departure diameter and departure time have been provided. The …

High-Probability Tasks And Task Completion Rates Of Students With Emotional And Behavioral Disorders., Amy R Hall

Electronic Theses and Dissertations

This dissertation is an investigation into the effects of high-probability tasks on the task completion rates of three students diagnosed with an emotional and behavioral disorder. It begins with a close look into best practices verses common practices, examines students supports currently available in schools, and highlights gaps present in today’s educational system for students who exhibit significant challenging behaviors. The dissertation reviews literature available on the topic of high-probability tasks as a logical solution to combating gaps in behavior support and describes methodology used to investigate the strategy and its effects. It closes by presenting data, conclusions, implications, and …

Characterization Of Fundamental Parameters That Modulate Acoustofluidic-Mediated Molecular Delivery To Cells., Connor Sterling Centner

Electronic Theses and Dissertations

Cell-based therapies represent the latest biotechnological revolution in medicine, but significant limitations exist in non-viral intracellular delivery techniques during manufacturing of cell therapies. To address these limitations, a novel acoustofluidic device was developed to deliver ultrasound waves into a flow chamber for rapid molecular delivery to human cells. Our acoustofluidic device delivers biomolecules by inducing expansion and collapse of exogenous gas-filled microbubbles (“cavitation”), which enhances molecular delivery to nearby cells. Experimental studies were conducted to characterize key parameters that influence acoustofluidic-mediated molecular delivery to human cells. A clinical ultrasound transducer was generally utilized with varying cationic microbubble concentrations. Intracellular delivery …

Divided We Fall: Gender-Based Occupational Segregation In Kentucky’S Executive Branch 2012-2020., Hillary Mcgoodwin Abbott

Electronic Theses and Dissertations

Fifty-eight years have passed since the Title VII of the Civil Rights Bill of 1964 was signed into law, yet discrimination in employment still occurs; the Kentucky Executive Branch is no exception. This paper will use Theodore Lowi’s agency typology and EEOC categorical data from the 2012 and 2020 Kentucky Office of Diversity and Employment Training Semi-Annual Report on Female and Minority Employment (SAR) to identify gendered occupational segregation in three distinct Executive Branch agencies, address potential contributing factors and areas of change (Alkadry & Tower, 2006; Lowi, 1985; Newman, 1994; Escriche, 2007). Addressing any underlying discriminatory practices that may …

Critical Thinking Or Critical Creativity: Applying De Bono's Six Thinking Hats To Speech-Language Pathology Education And Practice., Samantha Hahn

Electronic Theses and Dissertations

Decision-making is a fundamental skill that health care professionals use daily which involves the interaction of many cognitive systems. Critical and lateral thinking are two approaches to decision-making often cited in literature. Critical thinking emphasizes reasoning and systematic analyzation, while lateral thinking encompasses imagination and creativity. Speech-language pathology (SLP) is a prime example of a profession that amalgamates creative processes with organized methodologies. Edward de Bono described six styles of lateral thinking – each style is equated to a colored “hat”. This study sought to determine if an association exists between a given SLP student’s level of clinical experience and …

Discovering The Pathways And Go Terms Associated With Mettl3 Modified Circular Rnas In The Embryonic Cerebral Cortex Of Mice., Dunia Zedan

Electronic Theses and Dissertations

Circular RNAs (cirRNAs) are a class of RNA molecules that result from the alternative back-splicing events that join the 3’ and 5’ ends normally present in the linear RNA molecules. It has been published that cirRNAs can function as gene regulators and as “microRNA sponges” to negatively control the functions of microRNAs. While many studies have been conducted to understand the regulatory roles of Mettl3 in linear messenger RNAs, fewer contributions were applied to understand the impact of Mettl3 modified cirRNAs on gene expression and on the regulation of different KEGG biological pathways and GO terms. This thesis was conducted …

Meat The Future., Xin Chen

Electronic Theses and Dissertations

This research focuses on the subtle relationship between human life, the environment, and other animals that we live among every day. Under the mainstream social background of capitalism and a commodity economy, animals are the victims of constant consumption and exploitation. However, meat is a basic substance for human nourishment, especially in certain cultures. As a result, meat becomes an important part of the commodity economy in capitalist societies, wherein the supply must be filled to accommodate society’s demand. This research formed an exhibition using glass and ceramic artwork using a playfully satirical tone to offer a crucial alternative: how …

Clickbait., Roger Knight

Electronic Theses and Dissertations

Clickbait is a surround-sound, audio, video, and audience participation work for live electronics that connects its listeners to the music through the use of a variety of interconnected technologies. The topic of internet clickbait was the initial inspiration that grew into a personal and cultural question. Technological mechanics of live web-based services and data-mining informed those themes further. The interactive nature of internet clickbait drove efforts to establish a deeper connection between the audience and the music. To develop connections between people, applications, and the piece, Node.js, Google Cloud Services, VoiceRSS, and Max/MSP/Jitter video tools were used. This underpins a …

Automatic Testing Of Organic Strain Gauge Tactile Sensors., Brian P. Goulet

Electronic Theses and Dissertations

Human-Robot Interaction is a developing field of science, that is posed to augment everything we do in life. Skin sensors that can detect touch, temperature, distance, and other physical interaction parameters at the human-robot interface are very important to enhancing the collaboration between humans and machines. As such, these sensors must be efficiently tested and characterized to give accurate feedback from the sensor to the robot. The objective of this work is to create a diversified software testing suite that removes as much human intervention as possible. The tests and methodology discussed here provide multiple realistic scenarios that the sensors …

Forecasting Hypotension By Learning From Multivariate Mixed Responses.., Jodie Ritter

Electronic Theses and Dissertations

Blood Pressure is the main determinant of blood flow to organs. Hypotension is defined as a systolic blood pressure less than 90 mmHg or a diastolic blood pressure less than 50 mmHg. The severity and duration of hypotension is associated with low blood flow to organs often result in organ damage and a high mortality rate. Predicting hypotension prior to surgery and during the surgery can reduce the incidence and duration resulting in better patient outcomes. This thesis uses preoperative bloodwork and vital signs as well as perioperative vital signs in 5-minute increments as inputs to forecast hypotension. Hypotension can …

Machine Learning Analysis Of Acoustic Attenuation Measurements For Cellular Characterization., John T. Moore

Electronic Theses and Dissertations

T-cell therapies have been gaining popularity in recent years due to their cancer fighting potential. With remission rates improving in this field of immunotherapy, the demand for T-cell therapies has also increased; however, the cell processing techniques for these therapeutic products have yet to rise to the level of demand. The manufacturing process takes too long and a significant amount of processed cell batches can fail to meet safety requirements. These limitations of cell processing can be detrimental to patients seeking T-cell therapies. While current products have improved the time it takes to manufacture these therapeutic products, there is still …

Fabrication And Characterization Of Lactobacillus Crispatus Containing Bioprints For Bacterial Vaginosis Application., Anthony J. Kyser

Electronic Theses and Dissertations

Bacterial vaginosis (BV) is a condition in which healthy lactobacilli are replaced by an overabundance of pathogenic bacteria in the female reproductive tract. Current antibiotic treatments often fail to “cure” infection, resulting in recurrence in more than 50% of women, 6 months post-treatment. Recently, probiotics have demonstrated promise to restore vaginal health; however, as with other active agents, delivery requires once-to-twice daily administration. Recently, three-dimensional (3D)-bioprinting has enabled the fabrication of well-defined cell-laden architectures with tunable agent release, thereby presenting a novel approach with which to deliver probiotics. One promising bioink, gelatin alginate, was selected for study, due to its …

Acoustofluidic Delivery Of Gene Editing Compounds For Improved Immunotherapy Processing., Riyakumari K. Patel

Electronic Theses and Dissertations

Cell-based immunotherapies are a new generation of “living-drug” treatments for cancer and other diseases. Chimeric antigen receptor (CAR) T-cell cancer therapy has shown promising results in lymphoma and B-cell malignancies. Currently, there are six FDA-approved CAR-T drugs on the market, and all of them use viral transfection for reprogramming. While viral transfection is effective, there are safety concerns due to inconsistent transfection that limit the use of CAR-T therapy. Current non-viral transfection techniques generally have lower transfection efficiency than viral transfection. Additionally, these techniques can be toxic, time-consuming, non-transportable, and expensive. To address these limitations, a novel 3D printed acoustofluidic …

2d Materials Based Heterostructure For Quantum Tunneling: A Lithography Free Technique., Ali Alzahrani

Electronic Theses and Dissertations

Two-dimensional electron gas (2DEG) systems have played a vital role in the development of superior electronic devices including tunnel junctions consisting of two such 2DEG systems. With the advent of the new 2D electronic material systems, it has opened a new route for 2D–2D tunneling in such extended systems. In this study, we have utilized a plasma enhanced chemical vapor deposition (PECVD) technique to directly deposit graphene (nanowalls) and h-BN on Si/SiO₂ substrates to construct two-dimensional material based, vertically stacked electron tunneling devices free of expensive and cumbersome microfabrication steps. In the first study, we fabricated direct quantum tunneling …

Retention Of First-Generation College Students: Exploring The Effect Of Mental Health, Yana Sue Hendricks

Electronic Theses and Dissertations

The retention of First-Generation College Students is an issue faced across different universities in the United States. FGCS are faced with various challenges that impact their enrollment in post-secondary institutions and these challenges are presented as the factors that affect retention in this study. This study attempts to analyze the three factors that affect the retention of FGCS which are mental health, financial well-being, and social support. Drawing participants, from a post-secondary program run by the Workforce Solutions of West Central Texas who attend colleges in West Central Texas. This study used a cross-sectional survey design to collect and analyze …

Child Exit Types And Permanency Outcomes In Foster Care As Correlated To Casa Involvement, Grace Elizabeth Hill

Electronic Theses and Dissertations

This study sought to identify correlations between Court Appointed Special Advocate (CASA) activities and exit outcomes for children in foster care. Previous research on the impact of CASA has been inconclusive and offered mixed findings, so this study sought to build off of previous research while also exploring new areas of research that have not yet been investigated. Big Country CASA’s database, Optima, was utilized to retrieve data on cases that closed during the 2021 fiscal year (September 1, 2020, to August 31, 2021). This yielded a sample size of 75 cases. Through an analysis of these cases to test …