Digital Commons Network^™

Strategies And Processes That Promote Sustainability Of Campus Laboratory Schools In The Twenty-First Century., April Blakely

Electronic Theses and Dissertations

The purpose of this study was to identify and analyze patterns of institutional strategies and processes that promote the sustainability of laboratory schools housed and managed by institutions of higher education. First, a comprehensive analysis of the development, growth, decline, and current status of the laboratory school movement was conducted by means of a review of relevant literature. Next, an interview with the Director of the International Association of Laboratory and University Affiliated Schools (NALS) was conducted to gather information regarding the changing role of laboratory schools in the modern educational landscape of America. Subsequently, a survey of laboratory school …

Mechanisms Mediated By Cxcl12 Signaling Through Cxcr4 And Cxcr7 In Breast Cancer., Lasharon Denise Mosley

Electronic Theses and Dissertations

Interactions between chemokines and their receptors are involved in organ- specific homing and propagation of metastatic breast cancer (BrCa) cells. BrCa cells express higher levels of CXCR4 and CXCR7 mRNA and cell surface protein, than normal human mammary epithelial cells (HMECs). CXCR4 is ubiquitously expressed by a multitude of cancerous and normal cell types; while CXCR7 is differentially expressed by T helper lymphocytes, cancer cells, and normal epithelium. Importantly, recent studies show CXCR7 is highly expressed by activated endothelial cells (i.e., neovasculature), fetal liver cells, and many tumors, but not by non-transformed (or normal) human tissues. Unlike other chemokine receptors, …

The Role Of O-Glcnac Signaling In Acute Myocardial Ischemia., Gladys Afor Ngoh

Electronic Theses and Dissertations

O -linked ß-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT) adds, while O -GlcNAcase (GCA) removes O -GlcNAc from proteins. Albeit being a recruitable stress-induced signal in other tissues, the role of O -GlcNAc in the heart is unknown. Therefore, we hypothesized that O -GlcNAc is recruited in the heart during acute stress, and enhanced O-GlcNAc is cardioprotective. Subjecting neonatal rat cardiac myocytes (NRCMs) to hypoxia, or mice to myocardial ischemia reduced O-GlcNAc signaling. Augmented O-GlcNAc signaling attenuated, while diminished O-GlcNAc …

A Ferrari Engine With Bicycle Brakes : Mothers' Perceptions Of Family Communication Patterns When Having An Adhd Child., Anita Hoag 1967-

Electronic Theses and Dissertations

The purpose of this study was to explore how mothers with an ADHD child living in the household perceive and manage family communication. In-depth interviews were conducted amongst nine married mothers who have an ADHD child. Three themes emerged from the interview data: relational management, time management, and internal and external support. Mothers communicate with their ADHD child differently than their non-ADHD children and must also manage communication about the ADHD diagnosis. Mothers are not always open about their child's ADHD with non-family members as they are afraid of the stigma that is attached to the condition. Mothers recognize that …

The Role Of Pkc-Epsilon In Models Of Alcohol- And Toxin-Induced Liver Disease., J. Phillip Kaiser 1981-

Electronic Theses and Dissertations

Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there is no FDA approved therapy to treat or reverse liver damage caused by alcohol exposure. Whereas the mechanisms behind ALD are poorly understood, the disease progression is well known. The first pathological step of ALD is steatosis followed by inflammation and necrosis; if the insult(s) responsible for the previous pathologies persists, fibrosis and cirrhosis can then develop. In previous experimental studies, …

Friedrich Schiller's Play : A Theory Of Human Nature In The Context Of The Eighteenth-Century Study Of Life., Susan M. Bentley

Electronic Theses and Dissertations

Friedrich Schiller's psychological theory of play, his hypothesis about human nature, is embedded in the Aesthetic Letters . Its trans-historical value owes much to the committed interest in life in the late Enlightenment, and the theory itself is an example of that period's enthusiastic study of living organisms. It is within this context--of eighteenth-century natural history, natural philosophy and medicine--that the theory can be profitably evaluated. That it is also an example of the connection of the humanities of the time and the emerging life sciences suggests its usefulness as a paradigm today: as a general theory of human nature, …

Religiosity, Beliefs About Mental Illness, And Attitudes Toward Seeking Professional Psychological Help Among Protestant Christians., Juan Michael Thompson

Electronic Theses and Dissertations

Researchers have long been interested in the relationship among the separate fields of psychology and religion. This dissertation seeks to explore the differences in the way protestant Christians with various religious orientations view mental illness and how these views relate to their attitudes toward seeking professional psychological help. A total of 540 individuals from church congregations representing ten different denominations completed measures of religiosity, beliefs about mental illness, and attitudes toward seeking professional psychological help. Scores on these measures were analyzed to observe group differences between religious orientations and correlations among the orientations and dependent variables of belief about mental …

Effects Of Anxiety Reducing Interventions On Performance Anxiety In Graduate Nurses, Georgita Tolbert Washington

Electronic Theses and Dissertations

Every new nursing graduate is challenged to successfully transition from student to professional nurse. The stress involved in that transition can manifest itself as performance anxiety, a type of anxiety occurring when someone is the focus of attention and is fearful of interactions or of being humiliated or embarrassed. It occurs only in specific situations. The new graduate's performance is the focus of attention and evaluation. Further, the need to interact with other professionals, patients, and families can create anxiety about performance. No studies have examined performance anxiety in graduate nurses.

Use of cognitive behavioral therapy, progressive muscle relaxation, and …

Effects Of Participation In Inquiry Science Workshops And Follow-Up Activities On Middle School Science Teachers' Content Knowledge, Teacher-Held Misconceptions, And Classroom Practices, Linda F. Cepeda

Electronic Theses and Dissertations

An important aspect of developing science literacy for all students is developing science-literate teachers. With the implementation of the No Child Left Behind Act, many middle school teachers found themselves in a position where they were no longer qualified to teach middle school science. This study was designed to help science teachers increase their science content knowledge, identify and resolve misconceptions/errors they may have, and assist them in their teaching by providing strategies for inquiry-based teaching, science laboratory exercises, and science equipment.

Teachers enrolled in biology courses offered by the Rocky Mountain Middle School Math and Science Partnership participated in …

Computational Investigation Of Spin Traps Using Hybrid Solvation Models., Sai Sriharsha Manoj Konda

Electronic Theses and Dissertations

The cyclic nitrone 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), and the lesser known linear phenyl-N-tert-butylnitrone (PBN) and its phosphorylated analogues have been used as spin traps for the investigation of free radicals in biological systems. Theoretical work on these molecules suggests that there are important differences in their properties between biological systems and isolated molecules in the gas phase, most likely resulting from intra and intermolecular hydrogen bonding. Most dielectric solvation models such as the polarized continuum model and COSMO are incapable of direct determination of solvent-spin trap chemical interactions. To examine this, hybrid models incorporating COSMO for long range effects and discrete solvent …

Studies Of The Preparations And Use Of Sol-Gel For Enzyme Immobilization And Analytical Applications., Suzana Hamdan

Electronic Theses and Dissertations

Much attention has been paid to immobilization of enzymes to improve enzyme stability and permit its reuse. Glucose oxidase entrapment in different kinds of silica sol-gel matrices was investigated. The enzyme showed stable activity for 11 uses in the sol-gel with tetramethyl orthosilicate (TMOS) as precursor, and at least 7 uses in the sol-gel induced electrochemically with tetraethyl orthosilicate (TEOS) as precursor. The sol-gel made with TEOS as precursor and HCl as catalyst showed stability in enzyme activity for 11 uses but the activity decreases on the same sol-gel when modified with silica nanoparticles. Factors such as optimal incubation time …

Mapping The Dorsal Skin Pigmentation Patterns Of Two Sympatric Populations Of Ambystomatid Salamanders, Ambystoma Opacum And A. Maculatum From Northeast Tennessee., Lok Raj Pokhrel

Electronic Theses and Dissertations

Because of growing concern of habitat fragmentation and its adverse effects on salamander communities in Appalachian region, sympatric populations of ambystomatid salamanders A. opacum and A. maculatum were studied in Northeast Tennessee to address a number of questions: i) the extent of sexual size dimorphism (SSD) in both species, ii) what traits influence the dorsal skin pigmentation and how, iii) whether gender differences in developmental stability occur, and iv) the extent of phenotypic variation within each species. The findings of this study revealed SSD in both species of salamanders. The most parsimonious statistical model was developed that explained the influence …

A Phylogenetic Analysis Of Species Relationships In Hemlocks, The Genus Tsuga (Pinaceae)., Jordan David Baker

Electronic Theses and Dissertations

The genus Tsuga is comprised of eight extant species found in North America and East Asia and four species represented by fossils from Europe and Japan. This study presents the first phylogenetic analysis based on structural, biochemical, and molecular sequence data. Characters obtained from published and unpublished literature were combined with new morphological characters from seeds, seedlings, and leaf cuticle material. Results from parsimony analyses of these characters differed from the published molecular based phylogeny. The non-molecular based phylogeny resolves two separate clades, a North American and an Asian, but did not group the western North American species, as in …

Burnout Potential Among Certified Athletic Trainers In Southwest Virginia And Northeast Tennessee As Measured By A Modified Version Of The Maslach Burnout Inventory., Dennis Cobler

Electronic Theses and Dissertations

The purpose of the study was to examine the burnout potential of certified athletic trainers (ATCs) working in the regions of Southwest Virginia and Northeast Tennessee. To determine burnout potential, the Maslach Burnout Inventory-Human Services Survey was used. Permission to modify the inventory was obtained from CPP, Inc. Participants for the research study were identified by searching the NATA membership directory, state athletic training websites and state licensure websites. Sixty-seven ATCs were emailed invitations to participate. Fifty surveys were completed. Of these 50, five were eliminated from statistical analysis. Therefore, 45 surveys were satisfactorily completed producing a usable return rate …

Improving Teacher Morale With Team Building., Nanci Autumne Edmonds

Electronic Theses and Dissertations

The purpose of this study is to build a conceptual framework to explain the influence of team building among elementary school teachers to improve teacher morale. This framework is intended as the foundation for a team building model to provide principals and teachers with a guide for implementing sound team-building activities into inservice training and throughout the school year. What are the best practices for implementing team building and how can these practices encourage teachers to have a more positive outlook on their profession? The variables include school environment, school climate, different principals, principal changes, years of teaching experience, teaching …

Amphibian Habitat Usage Of Two Restored Bogs In Shady Valley, Johnson County, Tennessee., Amy P. Lucas

Electronic Theses and Dissertations

Adjacent terrestrial habitat surrounding wetlands are critical for the survival and success of many species that use them. The primary purpose of this study was to determine amphibian movement from adjacent habitats into Orchard Bog, a restored bog located in Shady Valley, Johnson County, Tennessee. In addition, a secondary bog, Quarry Bog, was also studied determining baseline presence/absence data

A total of 16 species from six families were observed throughout the study sites. Seven species of anurans, Bufonidae, Hylidae, and Ranidae and nine species of caudates in the families Plethodontidae, Ambystomatidae and Salamandridae were identified. Fourteen of the 16 species …

Novel Strategy For The Synthesis Of Allenes., Mark-Henry Mbahmi Kamga

Electronic Theses and Dissertations

Allenes are very important chemical reagents in organic synthesis. Due to their high reactivity, they have been extensively used to carry out a variety of unique and effective chemical transformations including but not limited to ionic and free radical additions and transition metal catalyzed cyclizations. As the chemistry of this group of compounds is explored further and their applications expanded there is a need to develop alternative and cost effective methods for their synthesis. Our approach involves the synthesis of allenes from oxa-bicyclo-alkan-2-ones by methyllithium induced Eschenmoser fragmentation of the bicyclotosylhydrazone derivatives.

Studies Of Capsaicinoids Contents Of Locally Grown And Commercial Chilies Using Reversed-Phase High Performance Liquid Chromatography., John Kailemia Muchena

Electronic Theses and Dissertations

Capsaicinoids are a class of compounds responsible for the "heat" of hot peppers. Capsaicin and dihydrocapsaicin have the highest burning effect. The aim of this work is to separate and quantify the two major capsaicinoids in fruits harvested at different stages of development and at different seasons. Simple and rapid HPLC method involves 73:27% methanol water mobile phase with C₁₈ stationary phase and UV-Vis detector set at 210 nm. The method showed good reproducibility with 1.74% - 4.72% relative standard deviations, a linear response within 0.65–45.5 and 0.25-17.5 μg/mL for capsaicin and dihydrocapsaicin, respectively. The method achieved average recovery …

Qualitative Models Of Neural Activity And The Carleman Embedding Technique., Azamed Yehuala Gezahagne

Electronic Theses and Dissertations

The two variable Fitzhugh Nagumo model behaves qualitatively like the four variable Hodgkin-Huxley space clamped system and is more mathematically tractable than the Hodgkin Huxley model, thus allowing the action potential and other properties of the Hodgkin Huxley system to be more readily be visualized. In this thesis, it is shown that the Carleman Embedding Technique can be applied to both the Fitzhugh Nagumo model and to Van der Pol's model of nonlinear oscillation, which are both finite nonlinear systems of differential equations. The Carleman technique can thus be used to obtain approximate solutions of the Fitzhugh Nagumo model and …

Studies Of Titanium Dioxide Nanoparticles And Surfactants Effects, Singly And In Combinations, On Luminescence Intensity Of Some Aromatic Compounds., Charles Anim Odame-Ankrah

Electronic Theses and Dissertations

Luminescence techniques are sensitive, selective, and widely used in analysis. Luminescence intensity is attenuated by quenchers. This research has focused on the use of surfactants such as CTAB, SDS, and TX-100 singly or together with TiO₂ nanoparticles to evaluate their individual and combined effects on some fluorescent aromatic compounds such as pyrene, fluoranthene, anthracene, phenanthrene, and carbazole. Rutile phase TiO₂ was synthesized using the low temperature sol-gel method. Carbazole and phenanthrene were severely quenched by all surfactants singly or in combination with TiO₂. Anthracene and fluoranthene showed some enhancement in their luminescence intensity. The most dramatic …

Reversed-Phase Hplc Determination Of Alliin In Diverse Varieties Of Fresh Garlic And Commercial Garlic Products., Aaron Kwaku Apawu

Electronic Theses and Dissertations

Alliin is a predominant flavor precursor in garlic cloves. It interacts with the enzyme alliinase when garlic cloves are crushed, cut, or chewed to produce allicin, an unstable thiosulfinate that is the main biologically active component of fresh crushed garlic. Biological functions and health benefits of garlic include reduction of cancer risk in humans, improving immune system, and anti-microbial, anti-oxidant, and anti-hypertensive activities. The quality of fresh garlic and garlic products is usually related to its alliin content and allicin release potential. This research presents a simple, rapid, and precise HPLC method for alliin determination. It involves the use of …

Differential Expression Of Genes During Diapause In The Flesh Fly, Sarcophaga Crassipalpis., Puja Karki

Electronic Theses and Dissertations

The objective of this study was to identify genes that are differentially regulated during diapause when compared with nondiapausing pupae in Sarcophaga crassipalpis. The results of a Suppression Subtractive Hybridization procedure was used to indentify genes that are differentially regulated in both diapause and nondiapausing states while suppressing genes that are common to both states. Randomly picked colonies from both subtractive libraries were isolated and the inserts sequenced. The sequences were analyzed using the bioinformatics tools NCBI, BlastX, Clustal W, etc. Out of 384 clones, 59 genes were found to be upregulated during diapause and 37 genes were found …

The Formation Of "Outsider" Through Labeling And Sentence Lengths For Immigrants Of Hispanic Descent., Jeremy Jason Smith

Electronic Theses and Dissertations

The purpose of this study was to determine if individuals who supported denying citizenship to children of foreign parentage and making English the sole language spoken in the United States held the opinion that a sentence length over 15 years was appropriate for non-U.S. individuals. Other purposes were to determine if individuals with high religiosity or who carried a lethal weapon also held the opinion that a sentence length over 15 years was appropriate for non-U.S. individuals.

Pearson's Chi-Square was used to determine if a significant relationship existed between the independent variables and the dependent variable. The data indicated that …

Concurrent Validity Of The Transdisciplinary Play Based Assessment-2, Keri E. Linas

Electronic Theses and Dissertations

Standardized assessment tools have been criticized for use with young children; however, there is limited empirical research supporting developmentally appropriate, play-based assessments. Forty children, with and without developmental disabilities, ages 10-73 months referred from the community of a large city received a transdisciplinary play based assessment (TPBA-2) and standardized assessment. Caretakers also completed the Vineland Scales of Adaptive Behavior. Concurrent validity between the TPBA-2 and standardized assessment tools (Bayley Scales of Infant and Toddler Development-III and the Mullen Scales of Early Learning) was demonstrated (p

(De)Composing A Garden For Children's Play, Debra Jean Deverell

Electronic Theses and Dissertations

Kindergarten has been a part of the educational landscape of the United States since 1856, when the first kindergarten opened in Watertown, Wisconsin. If we fast-forward more than a century and a half to the present, it is clear that the landscape composition of the garden-ideologically, culturally, socially, and politically for children's play has drastically changed.

The purpose of this study, (De)Composing a Garden for Children's Play, is to examine kindergartners' play set against changing school polices and practices of recent years in one Colorado school district. Four research questions guided this inquiry:

1. What does kindergarten look like …

The Longitudinal Factor Structure Of Parent Involvement And Its Impact On Academic Achievement: Findings From The Ecls-K Dataset, Hui-Fang Chen

Electronic Theses and Dissertations

The critical role of parent involvement has been endorsed by educators and educational policy in the United States. However, various definitions and approaches to assess parent involvement have yielded inconsistent conclusions regarding the impact of parent involvement on child development and failed to provide foundations for practitioners. These contradictory findings, at least in part, reflected that parent involvement is a multidimensional construct which should be captured by many behaviors and activities as well as the limitations of using classical test theory to develop/identify items to assess parent involvement.

This study conducted both CTT and IRT to identify optimal items for …

Life As A Sober Citizen : Aldo Leopold's Wildlife Ecology 118., Nancy Stearns Theiss

Electronic Theses and Dissertations

This historic case study addressed the issue of the lack of citizen action toward environmentally responsible behavior. Although there have been studies regarding components of environmental responsible behavior [ERB], there has been little focus on historic models of exemplary figures of ERB. This study examined one of the first conservation courses in the United States, Wildlife Ecology 118, taught by Aldo Leopold (1887-1948) for 13 years at the University of Wisconsin. Today, Aldo Leopold is recognized as an exemplary conservationist whose land ethic is cited as providing the ecological approach needed for understanding the complex issues of modern society. The …

Mitochondrial Targeting Of The Pro-Apoptotic Protein Bax : Role Of The Bax Carboxy-Terminal Tail., Stephanie Erin Brock 1980-

Electronic Theses and Dissertations

Here, I address the function of the carboxy-terminal hydrophobic helix of the pro-apoptotic protein Bax. There has been considerable controversy as to whether this sequence is required for the targeting and insertion of Bax into the mitochondrial outer membrane. The Bax carboxy-terminal tail is tucked into a hydrophobic pocket within the closed/inactive conformation of Bax. Apoptotic stimulation results in an opening of the Bax conformation, exposing a mitochondrial-targeting signal and subsequent insertion of Bax into the mitochondrial outer membrane. Here, I confirm that the Bax tail alone can specifically target and anchor a cytosolic passenger protein to the mitochondria. Surprisingly, …

Maintaining Adult Student-Parent Distal Relationships: An Explorartion Of Mediated Communication Among Thai Students In The U.S., Thammaphong Isarabhakdi

Electronic Theses and Dissertations

Although a growing amount of research in relational maintenance has began to focus intensively on long-distance relationships (LDRs), especially marital, dating, and friendship relationships, little attention has focus on the process of maintaining LDRs in non-Western families. The objective of this study was, first, to explore the experience of Thai adult students who maintain LDRs with their parents. Second, this study identified Thai students’ specific relational maintenance behaviors and examined the channels of mediated communication used among Thai adult students and their family members.

This study utilized a qualitative method framed by a grounded theory approach to uncover the experience …

Microfluidic Cell Sorting Techniques To Study Disease Processes., William Neil White

Electronic Theses and Dissertations

Circulating nucleated cell populations found in whole blood, including both white blood cells (leukocytes) and endothelial cells, provide an ideal platform for studies seeking to understand the disease processes for development of drugs and treatments. This thesis presents an automated microfluidic device developed for leukocyte enrichment from peripheral blood. Briefly, the device allows for complete lysis of red blood cells and comprehensive analysis of nucleated cell populations in terms of quantity and activation status. The microfluidic lysis device was used in two Sickle Cell disease (SCD) studies to understand the effect of leukocytes in the initiation of vasoocclusive crisis. Findings …