Digital Commons Network^™

Is Wrong Life All That Is Possible? Adorno And Aquinas On Ethics, Benjamin Hampshire

Electronic Theses and Dissertations

Theodor Adorno's ethical thought is encapsulated in his famous aphorism "Wrong life cannot be lived rightly." This dissertation explicates this alarming declaration, revealing the metaphysical, epistemological, and anthropological analyses that place Adorno's ethical thought into this intractable predicament. I argue that Adorno's ethical thought, while of absolute importance and worthy of consideration, can be moved forward through an engagement with the ethical thought of Thomas Aquinas, toward the possibility of right life.

Disconnects: Expectation And Experience In Intimate Interpersonal Relationships, Kristen Jenkins Hark

Electronic Theses and Dissertations

In the latter part of the 20th century and early 21st century, egalitarian views regarding gender communication have been dominant in the theory and practice of intimate interpersonal communication (IPC). During the same period research continued to report that the healthiest and most satisfying relationships fit within patterns of traditional marriage. Traditional intimate relationships tend to enact complementarian practices regarding gender roles in intimate IPC. This raises the question how might an exploration of a minimalist complementarian view that informs traditional relationships assist in sustaining healthy intimate IPC today? In the literature concerning the health of intimate relationships, namely marriage …

The Effect Of Astym Treatment On Muscle Performance, Ben Richard Kivlan

Electronic Theses and Dissertations

Purpose: Astym treatment is a manual therapy intervention that stimulates tissue regeneration and treats pain, limited mobility, and muscle weakness associated with musculoskeletal pathology. The purpose of this study was to determine if Astym treatment administered to the lower extremity would result in an immediate change of maximal force output during a unilateral isometric squat test among individuals with a lower extremity injury.

Methods: Forty-five subjects (14males; 31females) aged between 18-65 years participated in this study. The subjects were randomized into 3 treatment groups: 1) Control group - received no treatment 2) Placebo group - received a sham Astym treatment …

Parental Substance Abuse And Child Welfare Outcomes: A Study Of Biological Mothers And Their Children In Out-Of-Home Placement In Allegheny County, Courtney Lewis

Electronic Theses and Dissertations

This study uses logistic regression to examine whether parental substance abuse makes biological mothers more or less likely to have their children returned home if the children have been removed by the Office of Children, Youth and Families (CYF). CYF handles the executive branch child welfare responsibilities for Allegheny County, which includes the city of Pittsburgh, PA. The sample in this study included children who had been removed from the home for the first time in 2012, and was split by age, creating two models. Parental drug abuse was found to make the child less likely to reunify in both …

Are You My Brother's Keeper: Challenging The Systemic Racism That Fosters Low Expectations For Black Males In Public Schools, Shana Denise Nelson

Electronic Theses and Dissertations

This dissertation in practice investigates the problem of systemic racism fostering a culture of low expectations for Black males in public schools. This work frames this problem as a matter of social justice and utilizes Critical Race Theory to examine how it robs Black males of their academic potential. This work argues that to address this problem, educators must engage in learning opportunities that help to identify and challenge their race-based assumptions and stereotypes, develop their racial consciousness, cultural competencies, and professional practices, and recognize, interrupt, and address systemic racism. Provided is a working agenda that offers recommendations for how …

Methodology For Trace And Ultratrace Analysis Of Primary Amines, Sean Christopher Pawlowski

Electronic Theses and Dissertations

In the study of lipids, or "lipidomics," methods for the separation and identification of specific trace compounds are highly sought. Microdroplet techniques have allowed for the ability to handle and detect these trace amounts. The use of low volumes allows for a decrease of the effective mean free path allowing chemical reactions to be carried out efficiently at lower concentrations by performing the reactions in microdroplets as opposed to bulk containers. Microdroplets created on microfluidic devices as segmented flow plugs have the advantage of efficient mixing and minimal dilution or dispersion relative to other nanoliter scale capillary reaction methods. The …

A Retrospective Data Analysis In Veterans With Inflammatory Bowel Disease: Using Wagner's Chronic Care Model To Explore Medication Adherence, Lori K. Rizzo

Electronic Theses and Dissertations

Background

Medication adherence in inflammatory bowel disease (IBD) ranges between 7-72% . Increased healthcare utilization has been associated with non-adherence in IBD. Wagner's Chronic Care Model (CCM) posits that care coordination between primary and gastroenterology (GI) specialty care could improve adherence and healthcare utilization.

Methods

Guided by the CCM, a retrospective analysis was conducted in veterans with IBD to: describe medication adherence rates; describe healthcare utilization measured by ER visits and inpatient admissions; and describe care coordination measured by primary care and GI specialty care use. A secondary study aim was to explore the relationships between those key outcome variables …

Tackling Urban Poverty In The Secondary Learning Environment, Nina Marie Sacco

Electronic Theses and Dissertations

The problem of practice examined in this dissertation in practice is that many urban schools that serve low socioeconomic communities fail to engage and, therefore, empower students to succeed. The purpose of this dissertation is to identify how urban poverty presents in secondary learning environments (i.e. high schools), to report findings on how urban poverty presents in one urban high school, and to report on an emerging model for engaging stakeholders across the boundaries of school, academy, and community to improve student success for those who attend such schools. Urban students of low socioeconomic status who attend secondary schools with …

The Search For Novel Antibiotic Compounds Through Molecular Modeling And Structure-Function Analysis Of Cspe In E. Coli K12, Andre Duane Samuel

Electronic Theses and Dissertations

Escherichia coli K12 has the capacity to express nine Csp (Cold shock-related protein) gene products (CspA-I). These proteins share between 29 and 83 percent identity in their amino acid sequences and only one, CspA, has a solved crystal structure. One of the Csps shown to be involved in chromosome condensation is a 6.3 kDa protein called CspE and deletion studies of its homologues in Bacillus subtilis show that at least one of the Csp proteins is required for cell viability. All of the Csp proteins studied to date bind to single stranded nucleic acids. Knowing that at least one of …

Design And Synthesis Of Pyrimidine Fused Heterocycles As Single Agents With Combination Chemotherapy Potential, Roheeth Pavana

Electronic Theses and Dissertations

This dissertation describes the design, synthesis and biological evaluation of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are important antitumor agents. Tumor angiogenic mechanisms that are vital for tumor growth and metastasis are targeted by antiangiogenic agents. Antiangiogenic agents are usually not tumoricidal but are mainly cytostatic. Combination chemotherapy with antiangiogenic and cytotoxic agents have shown significant promise and several studies with such combinations are in progress in the clinic. …

The Coordination Chemistry Of Dithione Ligands: Design, Syntheses, Characterization And Reactivity Study Of Molybdenum And Select First Row Transition Metal Complexes, Benjamin Mogesa

Electronic Theses and Dissertations

The coordination chemistry of dithiolene complexes has attracted enormous interest by inorganic chemists due to their presence in biological systems and possible applications in material science. Dithiolene units have been identified at the active site of metalloenzymes, containing molybdenum and tungsten. Model complexes have played a significant role in understanding the structural and reactivity of the active site of these enzymes.

In Chapter 2, we report the synthesis of a series of molybdenum complexes, MoIVO(p-SC6H4X)2(R2Dt0), where R = iPr or Me and X = H, Cl, CF3, Me, OMe and tBu, to serve as model complexes for the active site …

Dopamine Transporter (Dat), Nicotinic Acetylcholine Receptor (Nachr), And Metabotropic Glutamate Receptor 2 (Mglu2) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics, Shaili Aggarwal

Electronic Theses and Dissertations

Numerous in vitro and in vivo studies implicate that certain ligands that interact with DAT, nAChRs, and mGlu2 have tremendous potential as anti-addiction therapeutics. However, understanding how these promising anti-addiction compounds interact with their major drug targets at the molecular level is limited because of the absence of human DAT, nAChRs, and mGlu2 x-ray crystal structures. This knowledge gap is important towards rationally designing new therapeutics for psychostimulant abuse and addiction. The objective of this research was to develop irreversible chemical probes based on promising anti-addiction lead compounds (i.e., pyrovalerone, bupropion, BINA, etc) to map their binding sites and poses …

Graduate Students' Perception Of Curriculum-Based Efficacy Of The Acquisition Of Multicultural Counseling Skills, Demond Ethridge Bledsoe

Electronic Theses and Dissertations

The United States is undergoing a period in which the demographics of the population are shifting drastically. The profession of counseling is tasked with providing services to diverse groups of clients, many of whom may have experienced racism, prejudice, and oppression as a result of their cultural or ethnic identity. Literature suggests that cultural and ethnic minority clients have poorer outcomes than their majority counterparts, and a significant factor in gaining positive treatment outcomes is the multicultural skill development in the clinician; however, little research focusing on effective delivery methods for multicultural skill development in counselor trainees has been conducted. …

Dopamine Transporter (Dat) And Metabotropic Glutamate Receptor 5 (Mglu5) Irreversible Probes For Identifying Anti-Psychostimulant Therapeutics, Ranganadh Velagaleti

Electronic Theses and Dissertations

Numerous behavioral studies indicate that dopamine transporter (DAT) inhibitors and metabotropic glutamate receptor 5 (mGlu5) negative allosteric modulators (NAMs) possess promising anti-addiction therapeutic properties. However, the lack of human DAT (hDAT) and mGlu5 X-ray crystal structures makes it difficult to understand how these promising anti-addiction compounds interact with their major drug targets at the molecular level. This knowledge gap represents an important problem towards rationally designing new therapeutics for numerous addiction disorders. The objective of this research was to develop irreversible chemical probes based on select DAT inhibitors and mGlu5 NAMs in order to map the corresponding binding sites and …

Factors Influencing Nurses' Intentions To Provide Weight Management Education To Hospitalized Obese Adults, Milissa Volino

Electronic Theses and Dissertations

Obesity is a sensitive, global health problem that impacts individuals of all ages and places individuals at risk for various chronic health problems. Nurses caring for hospitalized obese clients are in a prime position to provide them with timely information on weight management. This study utilized an exploratory sequential mixed method design to examine medical-surgical nurses' intentions to provide weight management education to hospitalized obese adults and the factors that influence nurses' intentions.

In phase 1, a focus group interview guide and nurse demographic form (NDF) were developed. Focus groups were conducted and analysis resulted in the creation of 15 …

The Race For Privilege In Blackness: Transformative Leadership In Traversing Space In Search Of Black Queer Cool, Tiffany Wilkins

Electronic Theses and Dissertations

This portraiture project, incorporating auto-ethnographic elements, investigating how African American educational systems became systems of oppression faced by lesbian, gay, bisexual, transgender and questioning (LGBTQ) youth of color, intentionally blends artist in creative glance with researcher in systemic inquiry and knowledge gathering (Lawrence-Lightfoot & Hoffman-Davis, 1997; Ellis et al., 2011).

An aspiring African American, gender non-conforming, lesbian leader is an auto-ethnographic portraiture exemplar: a counter-narrative of transcending obstacles overshadowing accessing college, graduate school, career success in education; doctoral ambitions with audacity within classes of pervasive racism, heterosexism and homophobia. Parallel instances of critical confrontations in predominantly Black secondary schools and …

A Comparison Of Teachers' Beliefs Of The Use Of Inquiry Teaching, Origin Of Knowledge Of Inquiry Teaching, And Student Achievement Between International Baccalaureate And Non-International Baccalaureate Primary Years Programme Schools, Lucy Haddock

Electronic Theses and Dissertations

The goal of improving student achievement is of paramount interest to all public schools. The focus of this research was to determine the difference between inquiry based teaching strategies and student achievement. Additionally, the researcher investigated the origin of inquiry based teaching knowledge and International Baccalaureate Primary Years Programme (IBPYP) affiliation. IBPYP affiliation was studied due to the nature of the IBPYP as an inquiry based philosophy of teaching. The McGill Strategic Demands of Inquiry Questionnaire (MSDIQ) was used to determine teacher beliefs of inquiry based teaching strategies. Student achievement was measured using Florida Comprehensive Achievement Test 2.0 (FCAT 2.0) …

Effects Of Nanosilver And Silver Nitrate Exposure On Fathead Minnows (Pimephales Promelas) And Zebrafish (Danio Rerio), Adam D. Hawkins

Electronic Theses and Dissertations

Silver nanoparticles (AgNPs) due to their unique antimicrobial properties are among the most widely utilized nanoparticle. Because of the nature of the products that utilize AgNPs, environmental release of AgNPs is inevitable. At greatest risk is the aquatic ecosystem due to known toxicity of the Ag + ion to aquatic organisms. Our goal was to use two fish models, fathead minnows (Pimephales promelas; FHMs) and zebrafish ( Danio rerio; ZFs), to study the effects of AgNPs on gill histopathology, Na+/K+-ATPase immunoreactivity, mucus production, bioaccumulation, particle uptake characterization, gill gene expression, and lethality in varying water parameters in comparison to the …

Regulators Of Repo: A Search For Gcm/Repo Transcription Factors, Kathy Ann Nipper

Electronic Theses and Dissertations

The role of the Drosophila melanogaster gene glial cells missing (gcm) is that of a binary switch in both the central nervous system (CNS) and the peripheral nervous system (PNS) in specification of the glial fate for multipotent precursor cells. However, Gcm is also essential for maturation of hematocytes and tendon cells ( Alfonso and Jones, 2002; Jones, et al., 1995; Hosoya et al., 1995; Soustell et al., 2004). The varied outcomes of gcm expression imply the interaction of co-factors capable of giving the Gcm protein different "meanings" in different developmental contexts. The Gcm target repo is expressed exclusively in …

Childhood Growth In An Oneota Community: Examining Long Bone Growth Differences In The The Juveniles At Norris Farms 36, Whitney Broughton

Electronic Theses and Dissertations

Oneota migration into the central Illinois River valley around ad 1300 resulted in a number of different interactions with Mississippian groups. Milner and colleagues (1991) identified significant numbers of perimortem injuries at the Norris farms 36 cemetery, along with biological markers for poor health, such as cribra orbitalia and porotic hyperostosis. They suggested that the threat of violence may have forced the Oneonta at Morton village to limit subsistence activities to circumscribed areas close to the settlement, thereby reducing the resource base and negatively impacting the health of the community. However, recent research (Bengtson et al. 2012; Bengtson and O'Gorman …

Evaluation Of Effects Of Epigenetic Modifications, Macromolecular Crowding, Degree Of Hydration, And Transcription Factor Binding On The Thermodynamic Stability Of Dna I-Motif Structures, Yogini Bhavsar

Electronic Theses and Dissertations

No abstract provided.

Location, Location: Factors Influencing Greenhouse Gas Fluxes From The Mississippi Delta Agricultural Region, Michael P. Keating

Electronic Theses and Dissertations

Methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2) fluxes from agricultural landscapes may contribute significantly to regional greenhouse gas budgets due to stimulation of soil microbial activity through fertilizer application. Few studies have made measurements of CH4, N2O, and CO2 from the dominant landscape features of the agricultural landscape: farmland, riparian zone, and wetland habitat. This study assessed gas emission variability from the Mississippi Delta agricultural landscape and explored the effects of hydrology and hydrophytic vegetation on gas emissions.

Gas collection chambers were utilized to make gas measurements from soybean and corn farmland, vegetated riparian buffer, and two vegetated …

Evaluation Of Wild Yam (Dioscorea Villosa) As A Demethylating Agent And Its Anti Metastatic Activity In Human Breast Cancer Cells, Pranapda Aumsuwan

Electronic Theses and Dissertations

No abstract provided.

Diagnostic Accuracy Of Self-Report Instruments In A Non-Clinical Sample: A Receiver And Operating Characteristics (Roc) Analysis, Lindsay Trent

Electronic Theses and Dissertations

No abstract provided.

Preparation, Characterization, And Delivery Of Antibodies Binding To A Model Oncogenic Rna, Human Initiator Trna, Jennifer Archer

Electronic Theses and Dissertations

Non-coding RNAs (ncRNAs) account for a higher percent of the genome than coding mRNAs, and are implicated in human disease such as cancer, neurological, cardiac and many others. While the majority of ncRNAs involved in disease were originally attributed to a class of RNAs called micro RNAs (miRNAs) with a small size of only about 19 -24 base pairs, emerging research has now demonstrated a class of long non-coding RNAs (lncRNAs) that have a size of over 200 base pairs to be responsible for gene regulation and other functional roles and have also found to contribute to pathogenesis in humans. …

A Phenomenological Analysis Of Undergraduate Teaching In The United States And The United Kingdom From The Perspective Of Current And Former Exchange Students, Barry Griffiths

Electronic Theses and Dissertations

While once almost indistinguishable, the systems of higher education in the United States and the United Kingdom have diverged during the past 200 years to the point where today there are few similarities. However, due to increasing globalization and the growing ubiquity of the internet, many contemporary issues in higher education are often faced by institutions across the globe. After detailing the historical role of scholarship and teaching in the two countries, this study concentrates on two aspects that have been extensively researched in recent years, namely the role of technology in the classroom and the balance that many modern …

The Role Of Lim Kinase 1 And Its Substrates In Cell Cycle Progression, Lisa Ritchey

Electronic Theses and Dissertations

LIM Kinase 1 (LIMK1), a modulator of actin and microtubule dynamics, has been shown to be involved in cell cycle progression. In this study we examine the role of LIMK1 in G1 phase and mitosis. We found ectopic expression of LIMK1 resulted in altered expression of p27Kip1, the G1 phase Cyclin D1/Cdk4 inhibitor. Overexpression of LIMK1 resulted in lower levels of p27Kip1 and p27Kip1-pY88 (inactive p27Kip1). Knockdown of LIMK1 resulted in elevated levels of p27Kip1 and p27Kip1-pY88. Together, these results suggest LIMK1 regulates progression of G1 phase through modulation of p27Kip1 expression. LIMK1 is involved in the mitotic process through …

Creating Constructs Through Categorization: Gender And Race, Joshua Simpkins

Electronic Theses and Dissertations

In U.S. society, the systems of gender and race operate to privilege and oppress individuals based on their location within these systems. All of the interactions an individual experiences as they go about their day-to-day lives are shaped by these interlocking systems. As a result, there is an extensive body of sociological literature addressing how individuals in U.S. society are privileged and oppressed on the basis of their perceived membership in gender and race categories; however, relatively little research exists examining how individuals come to be seen by others as members of gender and race categories in the first place. …

Reconciling Order And Progress: Auguste Comte, Gustave Le Bon, Emile Durkheim, And The Development Of Positivism In France, 1820-1914, Khali Navarro

Electronic Theses and Dissertations

This thesis discusses the philosophy of positivism in nineteenth century France. Based on an empirical vision of society, positivism advocated values of rationality, progress, and secularization. In that way, it stood as one of the defining systems of thought of the modern era. I discuss, however, an undercurrent of anxiety about those same values. Positivism's founder, Auguste Comte, argued that all sciences would become unified and organized under universal principles and empirical standards. He viewed the human mind as becoming more rationalized throughout history. In his later career, however, he argued that rationalism was a destructive force and that a …

Treatment-Specific Approaches For Analysis And Control Of Left Ventricular Assist Devices, George Faragallah

Electronic Theses and Dissertations

A Left Ventricular Assist Device (LVAD) is a mechanical pump that helps patients with heart failure conditions. This rotary pump works in parallel to the ailing heart and provides an alternative path for blood flow from the weak left ventricle to the aorta. The LVAD is controlled by the power supplied to the pump motor. An increase in the pump motor power increases the pump speed and the pump flow. The LVAD is typically controlled at a fixed setting of pump power. This basically means that the controller does not react to any change in the activity level of the …