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Front Matter: Cover Page, Letter From The Editors, And Editorial Board, Endeavors Journal

Endeavors: Mississippi State Undergraduate Research Journal

No abstract provided.

Ptp4a2 Promotes Leukemogenesis Through Inhibiting The P53 Tumor Suppressor Signaling Pathway In Leukemia-Initiating Cells, Shiyu Xiao, Michihiro Kobayashi, Yunpeng Bai, Wenjie Cai, Sergio Barajas, Mohammed Abdullahel Amin, Sasidhar Vemula, Chonghua Yao, Yuxia Yang, Christopher Borchers

Faculty Work Comprehensive List

Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is sustained by leukemia-initiating cells (LICs). Although protein tyrosine phosphatase 4A2 (PTP4A2), also known as phosphatase of regenerating liver 2 (PRL2), is highly expressed in AML, the mechanisms by which PTP4A2 promotes leukemogenesis are largely unexplored. In this study, we demonstrate that PTP4A2 promotes AML by inhibiting the p53 tumor suppressor pathway in LICs. Using KMT2A-MLLT3–driven AML as a model, we found that PTP4A2 deficiency activates p53 and induces LIC apoptosis and senescence, thereby extending the survival of recipient mice repopulated with Ptp4a2^−/− LICs. Mechanistically, PTP4A2 directly interacts with …

Alopecia Totalis Treated With Constitutional Medicine Calcarea Carbonica: A Case Report, Deepak Prasher, Urvashi Diwakar

Indian Journal of Research in Homoeopathy

Introduction: Alopecia totalis is an autoimmune disease that causes hair loss anywhere in the body, but it most commonly affects the hair of the scalp. It occurs in people of all ages and affects 1–2% of the human population. The homoeopathic literature suggests that cases of alopecia totalis have been treated successfully with homoeopathic medicines. Case Summary: This case highlights the potential of the individualised homoeopathic remedy in promoting hair regrowth in alopecia totalis in a 14-yr old girl. The patient was prescribed Calcarea carbonica 200C, 2 doses on the basis of totality of symptoms and individualisation. This evidence-based case …

Exfoliative Cheilitis Treated With Homoeopathic Medicine Nitricum Acidum: A Case Report, Dinesh Sura, Niharika Shaw, Rubina Bashir, Chintamani Nayak

Indian Journal of Research in Homoeopathy

Introduction: Exfoliative cheilitis is an uncommon, persistent inflammatory disorder that impacts the vermilion border of the lips, characterised by ongoing peeling, dryness, and occasional bleeding. The condition can be resistant to conventional treatment and often causes significant emotional distress. Case Summary: A 16-year-old male presented with chronic dry, scaly eruptions on his lips, accompanied with a burning sensation and bleeding for the past 8 months. He reported anxiety about his appearance and also about his father's health. Based on a thorough evaluation of his overall symptoms and repertorial analysis, he was prescribed a single dose of Nitricum acidum 200C. By …

Cholelithiasis Treated With Homoeopathy: A Case Report, Girish Gupta

Indian Journal of Research in Homoeopathy

Introduction: The supersaturation of bile with cholesterol, necessary for maintaining bile salts in soluble state, leads to precipitation of cholesterol and other bile components in gallbladder lumen resulting in formation of gall stones. Cholelithiasis is a common digestive disorder that affects about 15% of people over 50 years of age, however in younger individuals it is common between the age of 20–40 years. Gall stones are asymptomatic in about 80% cases, but 1–4% of patients may present with symptoms like pain, nausea and vomiting etc. due to obstruction to bile flow. The treatment of gallbladder stone depends on the clinical …

Intraepidermal Squamous Cell Carcinoma In Situ (Bowen's Disease) Managed With Classical Homoeopathy: A Case Report, Anastasia Leivada, Aaditi Lakshmana, Ioannis Constantaras, Seema Mahesh, George Vithoulkas

Indian Journal of Research in Homoeopathy

Introduction: Bowen's disease, also known as intraepidermal squamous cell carcinoma in situ (SCCIS), is a pre-cancerous skin condition with the potential for progression into invasive carcinoma. Long-term exposure to ultraviolet (UV) radiation from sunlight is considered a primary causative factor, leading to DNA damage and subsequent cellular mutations within the epidermis. Conventional treatments are generally effective but may be associated with complications, including pain, local infection, scarring, pigmentation changes, and occasional recurrence. Case summary: This case report describes a 58-year-old male with Bowen's disease who experienced limited benefit from conventional treatments and sought homoeopathic therapy. The patient was treated with …

Research Highlights, Sujata Madhukar, Sakshi Chaudhary

Indian Journal of Research in Homoeopathy

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Impact Of Anatomical Changes On Treatment Plan Robustness: A Comparative Study Of Intensity Modulated Proton Therapy And Volumetric Modulated Arc Therapy In Head And Neck Cancer., Jennifer Croft

Masters Projects

Head and neck cancer patients often experience anatomical changes during radiation therapy, including weight loss and tumor regression. These changes can alter planned dose distribution and affect treatment accuracy. Based on the previous understanding, IMPT offers highly conformal dose delivery but is sensitive to the patient’s geometry changes and daily setup uncertainties, while VMAT may provide greater stability under these uncertainties. However, as of today, there is no quantitative analysis and comparison between the two modalities using real clinical data. The purpose of this study is to compare the robustness of IMPT and VMAT for head and neck cancer by …

Neutrosophic Temperaments And Personality Evolution: A Conceptual Framework Of Evolution, Indeterminacy And Involution, Akbar Jadidi Mohammadabadi, Akbar Rezaei, Florentin Smarandache

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets And Systems, Vol. 100, 2026, Florentin Smarandache, Mohamed Abdel-Basset, Maikel. Leyva Vazquez

Neutrosophic Sets and Systems

No abstract provided.

Enhancing The Barrier And Mechanical Properties Of Kraft Paper For Food Packaging Using Poly (Lactic Acid) Coatings Via Dip-Coating Technique, Putu Hadi Setyarini

Makara Journal of Science

Moisture-resistant kraft paper is important for food packaging because it helps preserve product quality and extend shelf life. However, untreated kraft paper exhibits limited barrier performance owing to the porous and hydrophilic nature of its cellulose structure. Herein, the mechanical and barrier properties of kraft paper were enhanced by applying poly (lactic acid) (PLA) coatings using a dip-coating technique with PLA concentrations ranging from 1 to 5 g/100 mL and either single- or double-dip-coating cycles. The results showed that increasing the PLA concentration and applying a double dip-coating treatment consistently improved coating thickness, tensile strength, elongation at break, water resistance, …

Friction Stir Processing Of Cobalt-Chromium-Molybdenum For Improvements In Biomedical Applications, Kaleb Kiyoshi Bates

Theses and Dissertations

Friction Stir Processing (FSP) has been investigated as a means of microstructural modification aimed at improving mechanical properties such as corrosion resistance and wear resistance of biomedical-grade cobalt-chromium-molybdenum (CoCrMo) alloy. FSP was successfully completed on high-carbon ASTM F1537 CoCrMo plates with operating temperatures ranging from 630°C to 850°C by adjusting spindle speed, traverse speed, and forge force. Hardness, wear resistance, and corrosion resistance testing were performed, along with Electron Backscatter Diffraction (EBSD) to analyze grain refinement and phase structure. FSP produced grain refinement up to 97% relative to the untreated baseline across the investigated temperature range, with lower processing temperatures …

Tea Polyphenol-Assisted Green Synthesis Of Silver Nanoparticle-Boron-Doped Diamond Nanoparticles For Theophylline Electrochemical Detection, Prastika Krisma Jiwanti, Adira Ainun Tsalsabilla, Angellita Wijaya Gunawan, Siti Wafiroh, Mohammad Kalimanjaro, Mai Tomisaki

Makara Journal of Science

Drug theophylline is a bronchodilator used to treat asthma and chronic obstructive pulmonary disease (COPD), but precise monitoring is required to avoid side effects. Therefore, this study aimed to develop a screen-printed electrode (SPE) modified with a composite of green-synthesized silver nanoparticles and boron-doped diamond nanoparticles using tea polyphenols (Ag-BDDTP/SPE) for detecting theophylline. Formation of AgNPs was confirmed by UV-Vis spectroscopy, which showed a localized surface plasmon resonance peak at ~450 nm. Transmission electron microscopy revealed polydisperse nanoparticles with an average diameter of 39.94 nm. During the electrochemical detection of theophylline, square-wave voltammetry (SWV) was employed to evaluate signal-to-background (S/B) …

Multiplex Pcr Assay To Distinguish Porcine And Non-Porcine Meats In Processed Foods Using Specific Primers From Nadh Dehydrogenase And Atp Synthase Gene, Kristianto Nugroho, Amalia Prihaningsih, Rerenstradika Tizar Terryana, Slamet Diah Volkandari, Mastur Mastur, Puji Lestari

Makara Journal of Science

Food safety issues, such as food adulteration between halal and non-halal meats, are among the most serious problems in Muslim countries like Indonesia. Food adulteration produces a mixture of products that cannot be detected visually by customers, and it could lead to several social and health problems. The availability of a detection method that can disti-nguish between porcine and non-porcine meats is very important, particularly one that can be utilized in small-scale labo-ratories. The aim of this study was to design and optimize species-specific primers that could distinguish between porcine and non-porcine meats in processed foods by utilizing NADH Dehydrogenase …

Lafe0.925ti0.075o3 Perovskite Coated With Ethyl Cellulose: A High-Stability, Low-Hysteresis Platform For Advanced Humidity Sensing, Akhmad Futukhillah Fataba Alaih, Djoko Triyono, Rifqi Almusawi Rafsanjani

Makara Journal of Science

Humidity sensors are pivotal in numerous sectors, such as environmental monitoring, industrial automation, and health-care. This study presents the fabrication and detailed evaluation of an advanced humidity sensor using ethyl cellulose (EC)-coated LaFe_0.925Ti_0.075O₃ (LFTO) perovskite nanoparticles synthesized via the sol-gel method. The LFTO nanopar-ticles exhibited a mesoporous structure with an enhanced surface area, which significantly improved their moisture adsorption capabilities. The innovative application of EC coating addresses critical substrate adhesion issues, enhancing mechanical stability without compromising sensor sensitivity. Comprehensive performance evaluations revealed minimal hysteresis (

Performance Of A Fertilizer Sludge Contaminated With Heavy Metals Collected From Two Wastewater Treatment Plants On (Lactuca Sativa), Leila Lila Belkhedim, Yamina Tahri

Makara Journal of Science

The improper management of sewage sludge poses a significant global risk to environmental and public health. In this study, the valorization of sludge as an organic fertilizer for lettuce cultivation was evaluated, offering a sustainable waste-to-resource solution. Sludge from two wastewater treatment plants (Mazouna and El Kerma) were collected between 2019 and 2021. Comprehensive physicochemical analysis was conducted to determine its nutrient value and contaminant levels. In addition, the efficacy and safety of the fertilizer were assessed by measuring lettuce growth and the bioaccumulation of heavy metals in plant tissues. The analyzed sludge, with an organic matter content of 9.91%–83% …

Microplastic Analysis In Fish Larvae (Family: Gonostomatidae And Myctophidae) From The Banggai Sea, Indonesia, Noer Kholis, Luqman Ilyas Ardito, Luqmanul Hakim, Augy Syahailatua, Agus Saleh Atmadipoera, Rina Zuraida, Tuan Nurul Sabiqah Tuan Anuar, Mufti Petala Patria

Makara Journal of Science

Microplastic pollution is recognized as a threat to marine ecosystems, yet its impacts on early life stages of mesopelagic fishes remain poorly understood. This study investigated the occurrence and characteristics of microplastic ingestion in fish larvae of the families Myctophidae and Gonostomatidae from the Banggai Sea, Indonesia. Morphometric measurements and microplastic content were analyzed in 40 larvae (20 per family). Gonostomatidae larvae, despite being smaller in total length, exhibited significantly larger mouth widths and ingested more microplastic particles (mean = 3.90 ± 0.72 particles) than Myctophidae (mean = 3.40 ± 0.38 particles). Correlation analysis showed no significant relationships between morphometric …

In Silico And Toxicological Evaluation Of Crescentia Cujete Aqueous Extract: Potential Anticancer Activity Against Breast Cancer, Rahma Diyan Martha, Fatimah Fatimah, Syahputra Wibowo, Bantari Wisynu Kusuma Wardhani, Josephine Elizabeth Siregar, Elisabeth Farah Novita Coutrier, Alfia Fitrianita, Andri Pramesyanti Pramono, Ita Margaretha Nainggolan, Yudhi Nugraha, Danar Danar, Naufal Abiyyu, Lalu Unsunnidhal, Aswin Rafif Khairullah, Arif Nur Muhammad Ansori, Hesty Parbuntari, Wimbuh Tri Widodo

Makara Journal of Science

Majapahit plant (Crescentia cujete), commonly found in Indonesia, has not been extensively explored for its medicinal properties. Given that many cancer treatments are derived from plants, this study aimed to examine the effects of plants on cancer chemical composition of the C. cujete fruit pulp extract, identify its primary compounds, and assess its potential as an antioxidant, anticancer agent, particularly for breast cancer. An insilico approach was used to evaluate the toxicity and interactions, of the compounds with cancer biomarker proteins, in addition to an in vivo Brine Shrimp Lethality Test (BSLT) for BSLT, toxicity screening using six …

Morphometric And Genetic Analyses Of The Sheat Catfish Genus Ompok And Kryptopterus (Siluriidae) From The Mahakam River, East Kalimantan, Indone-Sia, Jusmaldi Jusmaldi, Rudhy Gustiano, Haryono Haryono, Rusdianto Rusdianto, Gema Wahyudewantoro, Syahroma Husni Nasution, Yulianto Yulianto, Muhammad Hunaina Fariduddin Aththar, Safar Dody, Amran Ronny Syam, Irin Iriana Kusmini, Yosmaniar Yosmaniar

Makara Journal of Science

Anthropogenic impacts within the watershed threaten the survival of sheat catfish. Therefore, species of the genera Ompok and Kryptopterus should be conserved and domesticated to ensure their long-term persistence. Moreover, the accurate documentation of the existence and taxonomic validity of Ompok and Kryptopterus species is crucial. Accordingly, this study aims to assess the species diversity of the genera Ompok and Kryptopterus in the Mahakam River, East Kalimantan, Indonesia. The study was conducted between June and December 2014, with an update in August 2024. Fish samples were collected from the upstream and middle reaches of the Mahakam River. A total of …

Screening For The Suitable Signal Peptide For Secreted Nattokinase Expression In E. Coli Using An In Silico Approach: Precursor Vs. Mature Forms, Dewi Purwani Caya Ningsih, Kartika Sari Dewi, I Wayan Martadi Santika, Ade Andriani, Joko Pebrianto Trinugroho, Muhammad Yusuf

Makara Journal of Science

Nattokinase (NK), an enzyme with thrombolytic activity, has been widely used in treating cardiovascular disease. The expression of NK in the E. coli cell host is favored due to its several benefits, though it often results in inclusion bodies. Appropriate signal peptides can be attached to the N-terminus of a protein to initiate a secretory expression system, thus preventing the nascent protein from aggregating in the cytoplasm. This study aimed to identify suitable signal peptides for the secretory expression of active NK in E. coli and to investigate the impact of pre-protein in NK secretion using an in silico approach. …

Unraveling The Role Of Tree Species Diversity In Climate Change Mitigation: A Case Study Of Ecuadorian Tropical Forests, Carlos Alfredo Salas-Macías, Ezequiel Zamora-Ledezma, Karime Montes-Escobar, Grover García-Saltos, Jerry Toth, Moises Tenorio-Mendoza, Juan Manuel Moreira-Castro, María Belen Vinces-Obando, Luis David Balarezo-Saltos

Makara Journal of Science

To address climate change, a crucial environmental challenge, strategies to reduce greenhouse gas emissions are essential. This study examines the relationship between tree species diversity, aboveground biomass (AGB), and carbon storage across tropical forests. The research was carried out in the Jama-Coaque Ecological Reserve and the Bosque Seco Lalo Loor Ecological Reserve in northwestern Ecuador, using 16 sample plots across five forest types: Mature Moist Forest (MMF), Cloud Forest (CLF), Early Succession Forest (ESF), Tropical Dry Forest (TDF), and Mature Semi-Deciduous Forest (MSF). To obtain indices of diversity and evenness, individual species were measured within plots, along with assessments of …

Ecological Patterns Of Culture-Recoverable Entomopathogenic Fungi From The Maize Rhizosphere Across Three Elevation Zones In West Java, Indonesia, Lilian Rizkie, Tjandra Anggraeni, I Nyoman Pugeg Aryantha, Agus Susanto

Makara Journal of Science

Entomopathogenic fungi (EPF) are important components of soil ecosystems and may support sustainable pest management in agricultural systems. This study characterized culture-recoverable EPF in maize (Zea mays L.) rhizospheric soils collected from 45 points across three elevation zones in West Java, Indonesia, using a spatially nested sampling design. Fungi were isolated by insect baiting with Tenebrio molitor larvae and direct soil plating. The isolates recovered were assigned to genera based on colony morphology and microscopic characteristics. Four EPF genera— Verticillium, Paecilomyces, Beauveria, and Metarhizium—were detected, with 34/45 samples (75.6%) positive for at least one recoverable …

Building Trustworthy Information Systems: A Unified Framework For Comparative Risk Detection, Parisa Momeni

USF Tampa Graduate Theses and Dissertations

Risk detection in large scale information systems increasingly depends on heterogeneous data generatedby both centralized and distributed ecosystems. While centralized systems provide curated and validated reports, distributed environments produce large-scale and real-time observational evidence. Existing computational approaches analyze these ecosystems in isolation, limiting systematic comparison of risk repre-sentations across heterogeneous sources.

This dissertation presents a unified computational framework for comparative risk detection across centralized and distributed information systems. The framework provides a domain independent methodology for transforming heterogeneous risk reporting data into comparable multidimensional representations. To enable interpretable comparison of heterogeneous risk distributions, this work introduces the Geometric Overlap Score …

Language Models For Oncology Clinical Text: How Model Architecture And Data Strategies Shape Tumor Phenotype Extraction And Disease Progression Detection, Thanh Duong

USF Tampa Graduate Theses and Dissertations

The rapid growth of electronic health records (EHRs) has created new opportunities to apply machine learning to clinical data.However, a large portion of important clinical information is still stored in unstructured text, such as pathology reports, radiology reports, and longitudinal clinical notes.These documents contain key details about tumor characteristics, diagnoses, treatments, and patient outcomes.Extracting structured and useful information from this text is challenging due to complex medical language, varied document formats, and the need to combine information across multiple reports over time.This dissertation studies how language models can be designed and adapted to better extract and use oncology-specific information from …

House Sparrow Invasion Success Across Ecological, Immunological, And Molecular Scales, Kailey Marie Mccain

USF Tampa Graduate Theses and Dissertations

Biological invasions offer natural experiments for studying how organisms cope with ecological novelty. Although invasion success is often attributed to enemy release, introduced organisms do not enter enemy-free environments. Instead, they enter heterogeneous landscapes in which some familiar enemies are absent, others remain, and entirely novel enemies may be encountered. The question, then, is how invaders (hereafter non-natives) are poised to respond to these threats? This dissertation examines whether successful invasions in house sparrows (Passer domesticus) is associated with shifts in pathogen exposure, immune dynamics in blood, gut physiology, and gene co-expression network structure.

Chapter 1 is at the population/ecological …

Mapping Seafloor Habitats And Characterizing Demersal Reef Fish Communities On The West Florida Shelf Across Multiple Spatial Scales Using Multibeam Sonar And Underwater Video, Alexander R. Ilich

USF Tampa Graduate Theses and Dissertations

In this dissertation, I examine the role of spatial scale in deriving seafloor terrain attributes, modeling benthic habitat, and analyzing ecological patterns of the demersal reef fish communities on the West Florida Shelf (WFS), with implications for improving predictive habitat mapping and understanding fish-environment relationships. Spatial scale plays a central role in benthic habitat mapping and ecological inference, influencing how terrain attributes are derived, how habitats are modeled, and how ecological responses are manifested. This work integrates multiscale terrain analysis, acoustic remote sensing, and community ecology to evaluate how spatial scale influences both physical habitat representation and ecological analysis.

Chapter …

Association Of Social Isolation, Loneliness, Social Strain And Support With Cancer Onset, And Frailty And All-Cause Mortality In People With Cancer, Joanne Elayoubi

USF Tampa Graduate Theses and Dissertations

Cancer is the second leading cause of death both in the United States and globally and for individuals over sixty-five. In 2026, approximately 2,114,850 new cancer cases are projected to emerge according to the National Center for Health Statistics (Siegel et al., 2026). Cancer incidence is increasing, making older adults sixty-five and older at risk of frailty and mortality following cancer. Although social isolation, loneliness, lack of social support, and social strain have been found to be risk factors for poor health and mortality, it is not clear the extent to which social relationships are associated with incident cancer, and …

Internal Neutrosophic Spiral Dynamics: Connecting Human Neutrosophic Evolution With The Law Of Internal Breakdown Of Dynamic Systems, Florentin Smarandache, Andrusa R. Vatuiu

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Approaches In Deep Learning For Ambiguous Medical Image Analysis: A Systematic Review Toward Wound Assessment, Zakaria Ahmed, Reda Ahmed

Neutrosophic Sets and Systems

No abstract provided.

Prochlorococcus Predation By A Globally Abundant Filter Feeder, Carey P. Sweeney, Avery Harman, Anvita U. Kerkar, Anne E. Aasjord, Daniel M. Chourrout, Terra Hiebert, Kelly Sutherland, Anne W. Thompson

Biology Faculty Publications and Presentations

Prochlorococcus is the most abundant photosynthetic cell on Earth and is critical to primary productivity and biogeochemical cycles of the open ocean. Appendicularians are ubiquitous gelatinous filter-feeding zooplankton that consume marine microorganisms including Prochlorococcus . However, the details of this trophic interaction are extremely understudied relative to their potential importance in top-down controls on Prochlorococcus . This study is the first to experimentally examine the feeding interaction between cultivated appendicularians and Prochlorococcus. We showed that Prochlorococcus ingestion rates by the appendicularian Oikopleura dioica increased with prey concentration and predator age. We revealed that appendicularians grazed equally on the 2 most …