Digital Commons Network^™

Weightlifting, Performing Arts Electives, And Academic Achievement: A Comparison In An East Tennessee High School, Lana Page

Electronic Theses and Dissertations

The purpose of this study was to determine if there was a significant relationship between the academic achievement as measured by ACT English, math, and composite scores of students who took 6 or more credits of weightlifting, 6 or more credits of performing arts, or no elective focus in an East Tennessee high school serving grades 9-12 from the graduating classes of 2010 through 2014. The independent variables were the elective focus groups students took during high school and race and ethnicity. The dependent variables were ACT English, math, and composite scores. A series of one-way analyses of variances (ANOVAs) …

Oxidative Damage To Dna 2´-Deoxyribose By Carbonate Radicals: Reaction Mechanisms And Products, Terence J. Moore

Electronic Theses and Dissertations

The carbonate radical anion (CO₃^•-, CR) is an important reactive oxygen species produced in vivo by one-electron oxidation of CO₂ or bicarbonate, constituents of the major physiological buffer. It was demonstrated for the first time by using an HPLC-based analysis of low-molecular products of DNA damage that CRs react with DNA 2΄-deoxyribose by the hydrogen abstraction mechanism. CRs exhibit a ~ 800-fold preference for one-electron oxidation of guanine over hydrogen abstraction from DNA sugar, in sharp contrast with •OH. CRs also have, as compared to •OH, an increased preference for the H1΄ abstraction, which is the …

“Our Weapon Is The Wooden Spoon:” Motherhood, Racism, And War: The Diverse Roles Of Women In Nazi Germany, Cortney Nelson

Electronic Theses and Dissertations

The historiography of women in Nazi Germany attests to the various roles of women in the Third Reich. Although politically invisible, women were deeply involved in the Nazi regime, whether they supported the Party or not. During Nazi racial schemes, men formed and executed Nazi racial programs, but women participated in Nazi racism as students, nurses, and violent perpetrators. Early studies of German women during World War II focused on the lack of Nazi mobilization of women into the wartime labor force, but many women already held positions in the labor force before the war. Nazi mistreatment of lower-class working …

Mathematical Modeling Of Immune Responses To Hepatitis C Virus Infection, Ivan Ramirez

Electronic Theses and Dissertations

An existing mathematical model of ordinary differential equations was studied to better understand the interactions between hepatitis C virus (HCV) and the immune system cells in the human body. Three possible qualitative scenarios were explored: dominant CTL response, dominant antibody response, and coexistence. Additionally, a sensitivity analysis was carried out to rank model parameters for each of these scenarios. Therapy was addressed as an optimal control problem. Numerical solutions of optimal controls were computed using a forward-backward sweep scheme for each scenario. Model parameters were estimated using ordinary least squares fitting from longitudinal data (serum HCV RNA measurements) given in …

Factors Impacting Success In Ninth Grade Algebra I For High School Students, James M. Lamie

Electronic Theses and Dissertations

The implementation of the Common Core State Standards (CCSS, 2013), No Child Left Behind Act of 2001, and the Race to the Top initiative of 2009 has placed a greater emphasis on high stakes testing. A renewed emphasis on math education for all students and their ability to succeed in high school mathematics place new challenges on today’s classroom teachers. Although the belief is that with new standards and best teaching strategies students will improve their test scores, there are multiple factors that can serve as deterrents to the success in mathematics for at-risk high school students (Balfanz, 2009). The …

Cloning And Expression Of A Tobacco Stearoyl-Acp Desaturase Gene Sbip24 And Its Interaction With Sabp2 In Sa Pathway, Amin J. Ferdous

Electronic Theses and Dissertations

Salicylic acid binding protein 2 (SABP2) that converts methyl salicylate to salicylic acid (SA) plays an obligatory role in the SA-mediated disease resistance pathway in plants. SABP2 interacts with SBIP24 in a yeast two-hybrid screening. SBIP24 belongs to the stearoyl-acyl carrier protein-desaturase protein family. To biochemically characterize the SBIP24, it was cloned from tobacco leaves using RT-PCR and expressed in E. coli. Recombinant SBIP24 was affinity purified using Ni-NTA chromatography. RT-PCR was performed to determine the role of SABP2 in modulating the expression SBIP24. TMV infected transgenic C3 (control tobacco plant containing empty silencing vector) and 1-2 (SABP2-silenced) …

Impulsivity, Venturesomeness, And Pride: Potential Moderators Of The Relationship Between Childhood Trauma, Substance Use, And Physical Aggression, Joshua P. Hatfield

Electronic Theses and Dissertations

Impulsivity, venturesomeness, and pride variables were examined as potential moderators of the associations between childhood trauma and physical aggression, alcohol use and physical aggression, and drug use and physical aggression. Participants (n = 457) were college students recruited from a university in the Southeast. It was hypothesized that childhood trauma, alcohol use, and drug use would be associated with increased scores of physical aggression. In addition, it was hypothesized that impulsivity, venturesomeness, authentic pride, and hubristic pride would moderate these relationships. Linear, multivariate hierarchical regression analyses were used to examine these variables as potential moderators. Hypotheses concerning hubristic pride as …

Brain Based Learning: K-12 Teachers’ Preferred Methods Of Science Instruction, Donna L. Mansy

Electronic Theses and Dissertations

The purpose of this quantitative study was to investigate Brain Based Learning (BBL) techniques in teaching science. Participants included 216 K-12, full-time, regular education teachers from 8 Northeast Tennessee school systems who taught at least 1 science class. Specifically this research was guided by 7 research questions on teachers’ perceptions and practices in teaching science.

Data were collected by a survey that consisted of 82 statements where teachers rated their level of agreement and was distributed online via Survey Monkey. The first portion of my survey included demographic identifiers, teachers’ knowledge of the term BBL, and inquiries regarding science background …

Gender Similarities And Differences In Experiences Of Public School Administrators, Marcia D. Fawver

Electronic Theses and Dissertations

The purpose of study was to examine similarities and differences in experiences between male and female high school principals and district administrators in addition to similarities and differences in leadership style and skills. This was an in-depth study with participants working in the same district and matched with descriptors such as age, similar position, and time served. Therefore the statement of the problem for the present study is what similarities and differences in experiences exist between male and female high school principals and district administrators in addition to similarities and differences in leadership style and skills.

Two male high school …

Cellular-Based Brain Pathology In The Anterior Cingulate Cortex Of Males With Autism Spectrum Disorder, Jessica D. Crawford

Electronic Theses and Dissertations

Autism spectrum disorder (ASD) now affects 1 in 68 children in the United States. Disorders within this spectrum share hallmark deficits in verbal and nonverbal communication, repetitive behavior, and social interaction. The cause of ASD is still unknown. Even though hundreds of genetic abnormalities have been identified in ASD, these markers account for less than 1% of all ASD cases. Researchers continue to search for pathological markers common to all or most cases of ASD. The research presented in this dissertation used a novel combination of state-of-the-art methods to investigate brain pathology in ASD. Postmortem anterior cingulate cortex (ACC) from …

Hif-1Α In The Heart: Provision Of Ischemic Cardioprotection And Remodeling Of Nucleotide Metabolism, Joe Wu

Electronic Theses and Dissertations

In our studies we found that stabilized expression of HIF-1α in heart led to better recovery of function and less tissue death after 30 minutes of global ischemia, via mechanisms that preserve the mitochondrial polarization. Our group previously showed that HIF-1α conferred ischemic tolerance by allowing cardiomyocytes to use fumarate as an alternative terminal electron acceptor to sustain anaerobic mitochondrial polarization. The source of fumarate was identified as the purine nucleotide cycle (PNC). Here we discovered that HIF-1α upregulates AMP deaminase 2 (AMPD2), the entry point to the PNC. The combination of glycolysis and the PNC may protect the heart's …

The Effects Of Vertically-Oriented Resistance Training On Golf Swing Performance Variables, Austin R. Driggers

Electronic Theses and Dissertations

The purpose of this study was to examine the effects of vertically-oriented resistance training on golf driving performance. Ten Division-I collegiate golfers completed 2 resistance training sessions per week for 10 weeks during the fall tournament season. Pre- and posttraining assessments of strength-power and golf performance were compared. To assess strength-power, jump height, peak force, and peak power (PP) were measured from static and countermovement (CMJ) vertical jumps; peak force and rate of force development from 0-250 ms were measured from an isometric mid-thigh pull. Golf performance was assessed in terms of ball launch speed (BS), spin rate, carry yardage …

A Comprehensive Study Of The Effects Of Neurotoxins On Noradrenergic Phenotypes, Neuronal Responses And Potential Intervention By Antidepressants In Noradrenergic Cells, Yan Wang

Electronic Theses and Dissertations

It has been reported that locus coeruleus (LC) degeneration precedes the degeneration of other neurons in the brain in some neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD). However, the precise mechanisms of neurodegeneration remain to be elucidated. N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) has been widely used as a noradrenergic neurotoxin in the development of AD and PD animal models for specific LC degeneration. However, the precise mechanism of action of DSP4 remains unclear. An increased systemic DNA damage caused by neurotoxin or oxidative stress has been found to be related to the pathogenic development of neurodegeneration. The process of neurodegeneration …

Identification, Cloning, And Expression Of Tobacco Responsive To Dehydration Like Protein (Rd22), Sbip-355 And Its Role In Sabp2 Mediated Sa Pathway In Plant Defense, Hanadi Abdulaali Almazroue

Electronic Theses and Dissertations

Abscisic acid (ABA) induces RD22, responsive to dehydration stress gene. Salicylic acid (SA) has been the focus of research due to its role against pathogens and abiotic stress. Interaction between ABA and SA signaling pathways is still poorly understood. SA-Binding Protein 2 (SABP2) converts methyl salicylate to SA. An attempt was made to identify proteins that interact with SABP2 using a yeast 2-hybrid screening. Several interactors were identified. One of them, SA-Binding Protein 2 Interacting Protein-355 (SBIP-355), showed high homology to RD22. Bioinformatic approaches showed that SBIP-355 contains a BURP domain. Phylogenetic analysis reveals that SBIP-355 clustered into the …

Development And Testing Of A Rapid Multiplex Assay For The Identification Of Biological Stains, Kevin M. Legg

Electronic Theses and Dissertations

While DNA profiling makes it possible to individualize biological stains, the identification of the stain itself can present forensic serologists with a significant challenge. Current antibody- and enzyme activity-based assays used by forensic practitioners for biological stain identification yield only presumptive results. Positive results with non-target body fluids or cross-reactivity with non-human sources has also been well documented. Some tests can consume unacceptable quantities of precious evidence while for some body fluids (vaginal fluid and menstrual blood) there are simply no available tests at all.

This research presented here aims to develop and rigorously test a fast, accurate, and sensitive …

Cavitation In Vial Drop Subjected To Mechanical Shock, Houman Babazadehrokni

Electronic Theses and Dissertations

Cavitation is a phenomenon that occurs when the local pressure falls down below the critical pressure. Previous work from the Randolph lab demonstrated that protein aggregates can form when a vial of therapeutic solution is dropped onto a hard surface. The process by which this occurs is most likely shock induced cavitation. During this process, hot spots can be created with temperatures and pressures reaching thousands of Kelvin and hundreds of atmospheres, respectively, leading to degradation of protein therapeutics. This work will extend previous efforts by exploring differences generated by change in vial materials, solutions, drop methods and fill volumes. …

Analyzing The Interactions Between Xenopus Tropicalis Mc2r, Mc5r, And The Mraps: Modeling The Regulation Of Frog Interrenal Cells, Yesenia Garcia

Electronic Theses and Dissertations

The role of Melanocortin 2 Receptor (MC2R) in adrenal/interrenal glucocorticoid secretion has been well documented in many organisms. Studies in mammals have shown that in the adrenal gland two melanocortin receptors and two melanocortin receptor accessory proteins are expressed: MC2R, MC5R, MRAP, and MRAP2. The MRAPs have an opposite effect on the cell surface expression of MC2R and MC5R. In mammals, MRAP aids MC2R but inhibits MC5R cell surface expression. This thesis aims to explore the functional relationship between MC2R, MC5R, MRAP, and MRAP2 in Xenopus tropicalis to determine if the MRAPs have a similar effect on amphibian MC2R and …

Constructing Water Budgets For A Coastal Stormwater Catchment To Examine Temporal Dynamics Between Urban Groundwater And Surface Runoff, Leigha E. Peterson

Electronic Theses and Dissertations

It is well understood that urbanization results in changes to the hydrologic cycle, namely increasing surface runoff production rates. Precipitation falling on impervious areas is typically directed via a network of drainage pipes to detention reservoirs, a process shown to negatively impact aquifer recharge rates. Historically, urban hydrologists have focused primarily on surface processes with little consideration to subsurface implications of the urban water cycle. Here, we present an approach to construct long-term, high-resolution water budgets for a coastal stormwater catchment resolving surface runoff and groundwater fractions within the water body and associated source-specific fluid exports to the coastal ocean. …

Fabrication And Characterization Of Small Scale Photo-Electro-Chemical Solar Cells, Xin Li

Electronic Theses and Dissertations

This thesis presents fabrication and characterization of a small scale photoelectro-chemical (PEC) solar cell.

The cell consists of a p-type silicon cathode with an etched micro-cavity that houses the zinc chloride electrolyte solution, and the cavity is covered by a sheet of zinc acting as the anode. The cell operates using a semiconductor-electrolyte junction instead of the p-n junction of a conventional solid state solar cell. The silicon electrode is fabricated by controlled wet etching so that the bottom of the micro-cavity becomes a very thin membrane, which allows photons to penetrate and reach the semiconductorelectrolyte interface for the generation …

Self-Esteem, Spirituality, And Acculturation And The Relationship With Depression In Latinos, Fernando M. Avila

Electronic Theses and Dissertations

The purpose of this dissertation is to examine the relationship between acculturation, self-esteem, spirituality and its association with depression in a community sample of Latinos. Previous research with Latinos has identified these factors as potentially being correlated with depression and with quality of life. The weight that these three variables can have on depression may be profound. Self-esteem and spirituality have been identified as protective factors that may assist individuals with depression by enhancing an individual's sense of worth. Acculturation is a construct that has been shown to influence Latinos in various ways. These variables have been established as predictors …

Real-Time Bio Sensing Using Micro-Channel Encapsulated Mems Resonators, Ayesha Iqbal

Electronic Theses and Dissertations

This work presents a label-free bio-molecular detection technique based on realtime monitoring of the resonant frequency of micromechanical thermal-piezoresistive rotational mode disk resonators encapsulated in microfluidic channels. Mass loading via adsorption of molecular layers on the surface of such devices results in a frequency shift. In order to provide a reliable platform for sample-resonator interactions and to protect the resonators from contaminants, the resonators were encapsulated in PDMS-based microfluidic channels. Micro-channel encapsulation also allows insulation of electrical signals from the analyte solution. To characterize the performance of such devices as real-time label-free bio-molecular detectors, the strong non-covalent binding of Avidin …

A Study Of Fetal Tissue Implantation For The Treatment Of Parkinson's Disease: Can Self-Efficacy And Social Support Predict Physical Functioning And Perceived Treatment?, Bethany L. Fiebelkorn

Electronic Theses and Dissertations

Few studies have comprehensively explored the benefit of fetal tissue implantation in Parkinson's disease (PD) patients. This type of investigation is necessary to better understand how and why some participants in a double-blind investigation of fetal tissue implantation for PD improved following the surgical procedure while others did not (Freed et al., 2001). Data for the present study were collected during a quality of life (QoL) study conducted by McRae et al. (2004) that sampled PD patients who participated in Freed et al.'s (2001) double-blind investigation of fetal tissue implantation. Several aspects of QoL were examined in McRae et al.'s …

Debtor's Empowerment: Muhammad Yunus And The Rhetoric Of Microfinance, Kaleb W. Brooks

Electronic Theses and Dissertations

This thesis analyzes the rhetoric of Muhammad Yunus as an articulation of a new governing logic, one that reconstitutes the concept of poverty and binds the poor to the apparatus of global capitalism through a new logic of micro-enterprise. Working within a Foucauldian critical framework informed by the rhetorical scholarship of Ronald W. Greene and Joshua Hanan, the argument proceeds by first paying careful attention to Yunus' work as constitutive of a new grid of intelligibility through which to view the poor and then demonstrating the application of this reformed discourse on "creditworthiness" in articulating a novel regime of commensuration. …

We Can Lie About How We Met: Msm Identity On Geo-Social Networking Applications, Levi Lindsey

Electronic Theses and Dissertations

Location-based applications (geo-social applications) gained popularity in 2010, for individuals to meet others around them with similar interests. These applications have become extremely popular within the MSM community (men who have sex with men) but have had limited success for other communities. Geo-social networking apps offer a unique opportunity for individuals to present their identities in a limited manner in order to meet other users. This research looks at how such identities are experienced, performed, and assembled digitally and why. Using a qualitative approach, I conducted 10 in-depth interviews with users of the geo-social networking application, Grindr, regarding how they …

Behind The Doors Of White Supremacy, Catlyn Kenna Keenan

Electronic Theses and Dissertations

What is the relationship between religious belief and acts of violence and terrorism? The American white supremacy movements of the Ku Klux Klan and Christian Identity are deeply rooted in Protestant Christianity and are also responsible for some of the gravest acts of violence on American soil. The intersection between religious belief and terrorist action illuminates the interplay between religion and acts of violence.

This study firstly provides a history of the ideology of Christian Identity with specific attention to the ways in which committing violence is rationalized and understood as redemptive. Secondly, this study identifies six characteristics of a …

Mitochondrial Involvement In Neuronal Cell Death, Josie J. Gray

Electronic Theses and Dissertations

Neuronal cell death via apoptosis or necrosis underlies several devastating neurodegenerative diseases associated with aging. Mitochondrial dysfunction resulting from oxidative or nitrosative stress often acts as an initiating stimulus for intrinsic apoptosis or necrosis. These events frequently occur in conjunction with imbalances in the mitochondrial fission and fusion equilibrium, although the cause and effect relationships remain elusive. In this thesis, I demonstrate in primary rat cerebellar granule neurons (CGNs) that oxidative or nitrosative stress induces an N-terminal cleavage of optic atrophy-1 (OPA1), a dynamin-like GTPase that regulates mitochondrial fusion and maintenance of cristae architecture. This cleavage event is indistinguishable from …

Transmission: Premium Television Characters Outside Of The Gender Binary, Daniel L. Ketchum

Electronic Theses and Dissertations

Five fictional characters have emerged on the U.S. premium-pay-cable channels that blur the traditional male-or-female gender divide. The basics of queer theory (sex, gender, orientation, and transgender) and critical/cultural studies (encoding, decoding, and reading a text) are explained as a basis for the analysis of the characters, which seeks to answer the research question: does the premium-pay-cable television format offer truly empathetic non-binary transgender characters that challenge the dominant American ideologies about gender identity and expression? If so, how? If not, why not?

Shane McCutcheon from Showtime’s lesbian melodrama The L Word (2004- 2010), Lafayette Reynolds from HBO’s supernatural drama-comedy …

Electron Paramagnetic Resonance Imaging And Probes, Hanan B. Elajaili

Electronic Theses and Dissertations

EPR imaging at low frequency is an important method to measure in vivo physiology. Because native paramagnetic species exist at low concentrations in living systems, exogenous paramagnetic species are needed for in vivo EPR. Selection of the appropriate EPR probe allows the experimenter to obtain information about the environment of the imaged probe and its spatial distribution. Relaxation times for several nitroxide radicals were studied with the aim of understanding the relaxation mechanisms, which provides criteria for design of suitable in vivo imaging probes.

Amino-substituted trityl radicals have the potential to monitor pH in vivo, and the suitability for this …

Putting The Person First : An Examination Of Thought Disorder And Personality Heterogeneity In Schizophrenia., Catherine Rose Robertson

Electronic Theses and Dissertations

The Recovery Model of mental illness, emerging as the new zeitgeist in regards to treatment, emphasizes the optimization of functioning for each individual, using personal strengths and preferences to drive the recovery process. Thought disorder has long been considered a core symptom of schizophrenia and has been implicated in multiple domains of functional outcome. In spite of its relationship to functioning and substantial heterogeneity of the phenomenon, little to no research has examined potential factors which may be related to these differences in thought disorder and its related domains of functioning. The current study proposes that “normal” personality traits, such …

The Problem Of The Twenty-First Century In The Cherokee Nation Is The Problem Of The Color-Line : How The Cherokee Freedmen Have Articulated A Sense Of Cultural Identity And Citizenship Claims Over Time., Shannon Spears

Electronic Theses and Dissertations

This research investigates the Cherokee Freedmen, who are people of African-American descent and peoples of mixed African-American and Native American descent, who were once enslaved by Cherokees in the Cherokee Nation, and who have articulated their identity and tribal citizenship status as Cherokee Natives in the Cherokee Nation. Upon emancipation, the Cherokee Nation adopted the Cherokee Freedmen as equal citizens in the Cherokee Nation under article nine from the Treaty of 1866, but this changed after citizens were recorded on the Dawes Rolls based upon blood quantum. The theoretical framework of this research is Antonio Gramsci’s theoretical perspective of cultural …