Digital Commons Network^™

American Myth And Ideologies Of Straight White Masculinity In Men's Literary Self-Representations, Mary Parish

Electronic Theses and Dissertations

This study examines three autobiographical texts written in post-World War II America (1959-1973) that take as their subject a straight white man’s reflection on and engagement with the exercise of male power and the forces, both internal and external, that shape the degree to which he is “self-made,” i.e., an autonomous agent able to exert his will within a life domain (domestic, public, and war). Each of these writers engages in surveillance not solely of their own power, but also of the men who influence their experience, using their observations to critique, assert, and question the gendered realities and expectations …

Effects Of A Green Chemistry Laboratory Design On First- Semester General Chemistry Students' Transformative Experiences In Chemistry, Lurea Joan Doody

Electronic Theses and Dissertations

The purpose of this study was to understand if a green chemistry laboratory design facilitated students’ transformative experiences in a first-semester general chemistry course for science majors. The study population consisted of 18 college students enrolled in the course at a small, rural, mid-Atlantic university. Traditional chemistry laboratories were replaced with three signature green chemistry laboratories over a period of 6-weeks at the end of the spring semester. Impact data were collected pre- and post, of the three labs using the Transformative Experience Questionnaire (TEQ) surveys. Open ended guided reflection questions were coded for elements of transformative experience (TE): expansion …

Using An Ethics Of Care To Re-Interpret Consent In The Management Of Care For Addiction Disorders, Diann Ecret

Electronic Theses and Dissertations

Patients who suffer from the biological, genetic, epigenetic neurocognitive dysfunction and social sequela of substance use disorders and addiction require the empowering support from healthcare professionals; necessitating the need to utilize an ethics of care to re-interpret consent for the management of care for those who suffer from substance use disorders and addiction. The care of the ‘other’ should embrace a care paradigm that is relational and collaborative in order to eliminate constructs of stigma, moral weakness and individual blame, which isolates those who manifest the trajectory of harms associated with addiction pathology. Relational consent and an ethics of care …

The Logic Of Sexuation In Deleuze And Lacan, Matthew Lovett

Electronic Theses and Dissertations

In The Logic of Sexuation in Deleuze and Lacan, I argue for an account of sexual difference that responds to a tension in feminist philosophy, namely, the problem of the ontological status of the sexed body. In so doing, I turn to the work of Gilles Deleuze and Jacques Lacan. I argue that, rather than being antithetical, the two can be productively read together, in particular with regard to this very question. Ultimately basing my reading in the Deleuzian passive syntheses and dynamic geneses of Difference and Repetition and The Logic of Sense as well as in Lacan’s twentieth …

Synthesis Of Novel 5-Substituted Pyrrolo[2,3-D]Pyrimidine Antifolates As Selective And Potent Anti-Tumor Agents, Mohammad Karim

Electronic Theses and Dissertations

In last few decades many folate analogs have been discovered and several compounds are successfully being used as anticancer agents. Methotrexate (MTX), pemetrexed (PMX), raltitrexed (RTX): are a few examples of classical antifolates that are currently in clinical use. Although these compounds are widely used, all of them show dose limiting toxicity due to their non-specific transport into normal cells as well as malignant cells. Currently, clinically used classical antifolates suffer from this disadvantage because there is no way to selectively transport them into malignant cells. Currently available antifolates are transported via reduced folate career (RFC) as well as Folate …

The Core Relation Between Hospitality (Philoxenia), Dignity And Vulnerability In Orthodox Christian Bioethics: A Contribution To Global Bioethics, Rabee Toumi

Electronic Theses and Dissertations

In a pluralistic world, reaching consensus in matters of bioethics has proved to be difficult, especially with the political polarization that nurtures inimical differences. This dissertation argues that a middle ground can be identified between the plurality of value systems in contemporary bioethics based on an anthropological approach. This middle ground that reflects commonalities of the human condition can be explored in relation to the foundational principles of Orthodox Christian anthropology. To identify this middle ground the analysis discusses the core relation between hospitality, dignity, and vulnerability as a contribution to global bioethics.

In general, based on Orthodox Christian theology …

An Ethics Of Care Approach To Managing The Burden Of Alzheimer's Disease, Carrie L. Stott

Electronic Theses and Dissertations

Alzheimer’s disease is a progressive, neurodegenerative disease for which there is currently no cure or effective treatments. The disease has devastating effects on the individuals whom it strikes and because its prevalence continues to rise, it significantly threatens the public good. Throughout its lengthy duration from diagnosis to death there are numerous ethical issues concerning patients individually as well as society generally. The management of the burdens of Alzheimer’s disease presents a formidable ethical challenge from the perspective of patients and society. The ethics of care is adopted to address this problem because of its flexibility to integrate personal care …

Differences In Perceived Stress, Locus Of Control, And Coping Styles Used By Male And Female Stem And Human Service Majors, Dawn M. Lowe

Electronic Theses and Dissertations

The current study sought to determine if program type along with gender could predict the type of coping styles students are more likely to use. Secondly, it endeavored to uncover whether a college student’s gender and program type might affect their locus of control and the amount of perceived stress reported. It was hypothesized that female students in Human Service programs would exhibit the most adaptive coping styles, while males in Science, Technology, Engineering, and Mathematics (STEM) programs utilize the most maladaptive coping styles. Moreover, it was postulated that females in Human Service programs would report a more internalized locus …

Petrographic And Stratigraphic Analysis Along The Lower Cretaceous Strata, In Kimble County Texas, Austin C. Wilkerson

Electronic Theses and Dissertations

The upper Trinity Group is predominantly a carbonate system with minor clastic couplets that were deposited during the Middle Cretaceous in the south Llano Uplift region. The upper Trinity Group was deposited on a southward dipping platform in the Kimble County area. Stratigraphic units of the upper Trinity Group are the Hensel Formation, determined to be supratidal claystones, the Glen Rose Formation, which are mudstones that were deposited in a carbonate lagoon, and the Walnut and Fort Terrett formations, which are wackestones to packstones interpreted to have been deposited on a shallow carbonate shelf.

Nine stratigraphic sections were measured along …

Self-Organized Structures: Modeling Polistes Dominula Nest Construction With Simple Rules, Matthew Harrison

Electronic Theses and Dissertations

The self-organized nest construction behaviors of European paper wasps (Polistes dominula) show potential for adoption in artificial intelligence and robotic systems where centralized control proves challenging. However, P. dominula nest construction mechanisms are not fully understood. This research investigated how nest structures stimulate P. dominula worker action at different stages of nest construction. A novel stochastic site selection model, weighted by simple rules for cell age, height, and wall count, was implemented in a three-dimensional, step-by-step nest construction simulation. The simulation was built on top of a hexagonal coordinate system to improve precision and performance. Real and idealized …

Universal Truths, Verisimilitude, And Hyperreality: Baudrillard’S Simulacra And Simulation In Pride And Prejudice And The Lizzie Bennet Diaries., Kathryn M. Kohls

Electronic Theses and Dissertations

This project applies Jean Baudrillard’s Simulacra and Simulation (1981) to Jane Austen’s Pride and Prejudice (1813) and Hank Green and Bernie Su’s The Lizzie Bennet Diaries (2012). By applying Baudrillard’s theory, one can see that Austen’s marriage plot is a shrewd critique of how social simulacra, simulations of reality, dictate how society is structured and interacts. These manipulative simulations are able to be transgressed by the novel’s protagonists, Elizabeth Bennet and Fitzwilliam Darcy. Their ability to find an unsimulated real is appealing to contemporary audiences caught in the hyperreality of the internet age. This leads to a panicked production to …

Loss Of The Na+/H+ Exchange Regulatory Factor 1 Results In Increased Susceptibility To Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle

Electronic Theses and Dissertations

Background. Acute kidney injury (AKI), an abrupt loss of kidney function which carries a high mortality and confers an increased risk of chronic kidney disease, develops in 30% of patients who receive cisplatin, a widely used chemotherapeutic agent [1], [2], [3]. The sodium hydrogen exchange regulatory factor isoform 1 (NHERF1) is a scaffolding protein that anchors multiple membrane proteins, in renal proximal tubules [4]. NHERF-1 deficient mice have aberrant localization of BBM proteins in intracellular compartments [5]. The investigators have recently demonstrated NHERF1 deficient proximal tubule cells have an underlying …

Chronic Pain Profiles And Past Bullying Experiences, Stephen Ratliff

Electronic Theses and Dissertations

The biopsychosocial model of chronic pain posits that chronic pain is influenced by factors such as depression, somatization, and psychological trauma (Gatchel, Peng, Peters, Fuchs, & Turk, 2007). Being bullied in childhood is one such factor that has been shown to be associated with chronic pain (Sigurdson, Wallander, & Sund, 2014; Voerman et al. 2015). Furthermore, those with chronic pain fit into one of three distinct psychological profiles (Williams, Urban, Keefe, Shutty, & France, 1995). The purpose of the current study was to examine the relationship between chronic pain profiles and reports of past bullying experiences. It was hypothesized that …

Separating Self-Esteem From Self-Concept Processes: An Investigation Of Emotional Responses To Self-Image Threat, Andrew Schwarzkopf

Electronic Theses and Dissertations

The researcher examined self-concept/self-image and self-concept maintenance processes in response to self-image threat. Replicating previous research, the researcher hypothesized that those who had self-image threatened would not engage in derogatory behavior in order to maintain self-concept (Fein & Spencer, 1997). Participants completed a false intelligence test giving negative, neutral, or positive feedback and were given an opportunity to evaluate members of a locally stereotyped or locally nonstereotyped social group for a hypothetical job position. No significant main effects or interactions were found for feedback or applicant social group on participant evaluations of applicants, indicating that derogation did not influence judgements …

Domestic Violence And Women: A Critical Analysis Of Us Help & Support Websites And Traditional News Media Representation, Jessica Lammon Oswald

Electronic Theses and Dissertations

This paper critically examines the ways in which US government organizations that provide help for domestic violence victims and traditional news media, specifically The New York Times, communicate the various factors of domestic violence and its victims. The author provides a focused literature review of gender, sexism, race, power, and voice, related to the idea of domestic violence in the US society and culture today. The literature review also demonstrates the need to investigate this issue as represented through mediated forums in the backdrop of the 2016 Trump Presidential campaign. The analysis reveals that communication about domestic violence encompasses …

A Comparison Of Four Wetlands Assessment Procedures Relevant To The Alluvial Valleys Of East Texas, Amy Camp

Electronic Theses and Dissertations

Currently several methods are used by public and private entities to assess wetland functional condition in support of the Section 404 Clean Water Act program. Four of these are: Forested Wetlands in Alluvial Valleys of the Coastal Plain of the Southeastern United States (SEHGM); A Regional Guidebook for Applying the Hydrogeomorphic Approach to the Functional Assessment of Forested Wetlands in Alluvial Valleys of East Texas (ETXHGM); Texas Rapid Assessment Method (TXRAM); and the Wildlife Habitat Appraisal Procedure (WHAP). Little previous research compares wetland functional assessment methods. Results of the SEHGM, ETXHGM, TXRAM, and WHAP methods were compared on five East …

Changes In The Microbial Community Of Lubomirskia Baicalensis Affected By Red Sponge Disease, Colin Rorex

Electronic Theses and Dissertations

Lake Baikal is the oldest known lake and a unique ecosystem, home to several species of fresh water sponge. A disease outbreak affecting the dominant species, Lubormirskia baialensis, was recently reported. The cause of the disease has not been determined but one of the current hypothesis is that the increase in methane concentration is correlated to the disease outbreak. This pilot study characterized the microbiomes of sick and healthy sponges through the use of 16S rRNA sequencing. Sick sponge microbiomes shared a conserved group of taxa while the healthy sponge microbiomes had greater diversity. Indicator species analysis identified two significant …

Computational Modeling Of Electronically Excited States In Cobalamin-Dependent Reactions., Brady D. Garabato

Electronic Theses and Dissertations

The current understanding of the photolytic properties of Vitamin B12 derivatives or cobalamins are summarized from a computational point of view. The focus is on two non-alkylcobalamins, cyanocobalamin (CNCbl) and hydroxocobalamin (HOCbl), two alkylcobalamins, methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), as well as the stable cob(II)alamin radical. Photolysis of alkylcobalamins involves low-lying singlet excited states where photo-dissociation of the Co-C bond forms singlet-born alkyl/cob(II)alamin radical pairs (RPs). Potential energy surfaces (PESs) of low-lying excited states as functions of both axial bonds provide the most reliable tool for analysis of photochemical and photophysical properties. Due to the size limitations associated with the …

Characterization Of Type Ii Toxin Anti-Toxin Systems In Aggregatibacter Actinomycetemcomitans., Blair W. Schneider

Electronic Theses and Dissertations

Microbes express many protective mechanisms in response to environmental stress. Toxin/anti-toxin systems encode a biologically active toxin and a labile anti-toxin that inhibits the toxin’s activity. These systems are known to contribute to persister cell and biofilm formation. A. actinomycetemcomitans thrives in the complex oral microbial community and is subjected to continual environmental flux. Little is known regarding the presence and function of TA systems in this organism or their contribution survival in the oral environment. Using BLAST searches and other informatics tools, we identified 11 intact TA systems that are conserved across all seven serotypes of A. actinomycetemcomitans and …

Machine Learning For Omics Data Analysis., Ameni Trabelsi

Electronic Theses and Dissertations

In proteomics and metabolomics, to quantify the changes of abundance levels of biomolecules in a biological system, multiple sample analysis steps are involved. The steps include mass spectrum deconvolution and peak list alignment. Each analysis step introduces a certain degree of technical variation in the abundance levels (i.e. peak areas) of those molecules. Some analysis steps introduce technical variations that affect the peak areas of all molecules equally while others affect the peak areas of a subset of molecules with varying degrees. To correct these technical variations, some existing normalization methods simply scale the peak areas of all molecules detected …

Biophysical Exploration Of Conformational Environments In Zymogen Prothrombin And Blood Coagulant Thrombin., Ramya Billur

Electronic Theses and Dissertations

The serine protease thrombin plays important roles in coagulation, anticoagulation, and platelet activation. Thrombin is initially expressed as the inactive zymogen prothrombin (ProT). The final cleaved and activated form of thrombin has mature anion binding exosites (ABEs) and several regulatory loops. Engagement with these exosites helps define the fate of thrombin as a procoagulant or an anticoagulant. Researchers previously reported that zymogen ProT may already bind exosite ligands. Little is known about conformational changes associated with ProT maturation, resultant ligand binding affinities, individual ligand-protein contacts, and long-range communication between thrombin exosites. Protease Activated Receptors (PARs) play critical roles in controlling …

Maturation Of Human Induced Pluripotent Stem Cell Derived Engineered Cardiac Tissues Using Chief Transfection And Chronic Optical Pacing., Marc M. Dwenger

Electronic Theses and Dissertations

The immaturity of engineered cardiac tissues (ECTs) limits their ability to regenerate damaged myocardium and to serve as in vitro disease models and surrogates for drug toxicity testing. Several chronic biomimetic conditioning protocols, including mechanical stretch, perfusion, and electrical stimulation promote ECT maturation but have significant technical limitations. Non-contacting chronic light stimulation using heterologously expressed light-sensitive ChIEF ion channels, termed optogenetics, may be an advantageous alternative to chronic electrical stimulation. As a proof of principle, we transfected ECTs using an AAV packaged ChIEF and then verified acute optical pacing (OP) by patch clamp. We then chronically OP ECTs for 7 …

T Socio-Ecology Of Managed Honeybees (Apis Mellifera) In The Louisville Metro Area., Haileigh M. Arnold

Electronic Theses and Dissertations

Humans have a long history of the practice of beekeeping to harness the power of pollination. This managed pollinator system consists of beekeepers, honeybees, and their environment. However, recent disease, pesticide use, and land use factors honeybee threaten this relationship. In the face of such concerns it is important to examine the factors that impact and can help sustain our managed pollinator systems. In this thesis, the national and Kentucky state-level policies that affect managed pollinator systems were examined and socio-ecological factors that may contribute to honeybee hive growth and losses were assessed along an urban development gradient in Louisville, …

Implementation Of Emergency Preparedness In Long Term Care And Rogers' Diffusion Of Innovation Theory., Elizabeth M. Shiels

Electronic Theses and Dissertations

Kentucky is one of the top ten states in the U.S. in the number of Presidential Declarations of Disaster (PDD) over the past ten years. This is due to its geology and weather patterns. The far western portion of Kentucky lies on the New Madrid Seismic Zone, one of the most dangerous fault lines in the United States; and natural hazards such as tornadoes, earthquakes, flash floods, severe storms offer only minutes or even seconds of advance notice. These “no-notice” emergencies with no timely warnings are the most common hazards experienced in Kentucky. In these events, individual long term care …

Challenges In Flexible Microsystem Manufacturing : Fabrication, Robotic Assembly, Control, And Packaging., Danming Wei

Electronic Theses and Dissertations

Microsystems have been investigated with renewed interest for the last three decades because of the emerging development of microelectromechanical system (MEMS) technology and the advancement of nanotechnology. The applications of microrobots and distributed sensors have the potential to revolutionize micro and nano manufacturing and have other important health applications for drug delivery and minimal invasive surgery. A class of microrobots studied in this thesis, such as the Solid Articulated Four Axis Microrobot (sAFAM) are driven by MEMS actuators, transmissions, and end-effectors realized by 3-Dimensional MEMS assembly. Another class of microrobots studied here, like those competing in the annual IEEE Mobile …

Long-Term Dental Outcomes Of The Professional Education Preparation Program., Samuel D. Petersen

Electronic Theses and Dissertations

Introduction: The Professional Education Preparation Program (PEPP) is a health careers pipeline program for Kentucky pre-health students from Health Professional Shortage Area counties and/or racial/ethnic groups underrepresented in the health professions. The purpose of this study was to determine the demographics of the dental PEPP participants and if, post dental school graduation, they were providing care for underserved patient populations Methods: PEPP dental graduates (n=114) had been previously identified. Participants were contacted by phone, asked to participate and then mailed a survey. Survey questions covered personal, practice and patient characteristics, procedures performed, insurance accepted and community outreach. Logistic regression analysis …

Intraoral Imaging At Insertion Of Implant Supported Restorations At An Academic Institution : Conformity To Established Guidelines., J. Alec Power

Electronic Theses and Dissertations

The objective of this study was to establish the frequency of intraoral imaging at the time of insertion of implant supported restorations at University of Louisville School of Dentistry (ULSD). After IRB approval (14.1215), patients on whom an implant-supported single unit fixed restoration was placed were identified from the electronic health record over a 4-year period. Type of prosthesis retention (cement vs. screw) and discipline responsible for crown placement was recorded. Bitewing (BWx) or periapical (pa) images taken at the time of prosthesis placement were accessed and reviewed. Overall radiographic frequency according to modality was tallied and compared using Chi-square …

Conciencia Bilingüe : The Multilingual And Academic Writing Practices Of Undocumented Immigrant Activists., Sara Del Pilar Alvarez

Electronic Theses and Dissertations

This qualitative research and community-based engagement focuses on the critical examination of the texts that 12 U.S. Southern and New York City undocumented young adults have produced in relation to immigrant rights advocacy. Adapting Lillis and Curry’s 2010 text-oriented ethnography methods and drawing on a collective framework informed by García and Wei’s (2014) theorization of dynamic bilingual practices, translingual theories of language difference in academic writing (Horner et. al, 2011; Lu & Horner, 2016), and Flores’s and Rosa’s (2015) call for raciolinguistics as a way to interrogate academic writing, this study examines the bilingual stances that these immigrant activists bring …

Photonic Tools For Advanced Sensing And Imaging At The Nanoscale., Jafar Hamed Ghithan

Electronic Theses and Dissertations

This dissertation reports a novel bio-sensing strategy based on single-mode, electro-active, integrated optical waveguide (SM-EA-IOW) platforms. It also reports the development of a super-resolved far-field optical imaging tool to enable optical, electronic, and spectroelectrochemical investigations at the nanoscale. SM-EA-IOW platforms with its outstanding sensitivity for spectroelectrochemical interrogation was combined with a sandwich bioassay for the development of a novel immunosensing based strategy for label-free detection of infectious pathogens. The strategy begins with the functionalization of the electroactive waveguide surface with a capturing antibody aimed at a specific target analyte. Once the target analyte is bound to the photonic interface, it …

Maintainability Analysis Of Mining Trucks With Data Analytics., Abdulgani Kahraman

Electronic Theses and Dissertations

The mining industry is one of the biggest industries in need of a large budget, and current changes in global economic challenges force the industry to reduce its production expenses. One of the biggest expenditures is maintenance. Thanks to the data mining techniques, available historical records of machines’ alarms and signals might be used to predict machine failures. This is crucial because repairing machines after failures is not as efficient as utilizing predictive maintenance. In this case study, the reasons for failures seem to be related to the order of signals or alarms, called events, which come from trucks. The …