Digital Commons Network^™

Interprofessional Relationships In Rural Offender Re-Entry And Management: Mental Health Treatment Providers And Community Supervision Professionals, Michael Lasher

Electronic Theses and Dissertations

The current prevailing approach to managing offenders in the community involves community supervision professionals such as probation and parole officers partnering with other community professionals, such as psychologists, social workers, and other mental health providers to address offenders’ needs. Each type of professional draws from a unique field with goals, values, and theoretical orientations, which do not necessarily overlap. These relationships are rarely studied, and previous examinations are limited. The current study aims to address this deficit in the empirical literature. Drawing on data obtained from qualitative interviews, four aims were examined. First, using thematic analysis, interview data are analyzed …

Immobilization Of Gold Nanoparticles On Nitrided Carbon Fiber Ultramicroelectrodes By Direct Reduction, George Affadu-Danful

Electronic Theses and Dissertations

Due to enhanced properties such as large surface area-to-volume ratio, metal nanoparticles are often employed as catalysts for various applications. However, most studies involving nanoparticle catalysts have been conducted on collections of particles rather than single nanoparticles. Results obtained for ensemble systems can be difficult to interpret due to variations in particle loading and interparticle distance, which are often challenging to control and characterize. In this study, two immobilization strategies for incorporating gold nanoparticles (AuNPs) on carbon fiber ultramicroelectrodes (UMEs) were compared with the goal of extending these techniques to nanoelectrodes for studies of single AuNPs. Both layer-by-layer deposition of …

Quantitative Studies Of Amyloidogenic Protein Residue Interaction Networks And Abnormal Ammonia Metabolism In Neurotoxicity And Disease, Jeddidiah Griffin

Electronic Theses and Dissertations

Investigating similarities among neurological diseases can provide insight into disease processes. Two prominent commonalities of neurological diseases are the formation of amyloid deposits and altered ammonia and glutamate metabolism. Computational techniques were used to explore these processes in several neurological diseases. Residue interaction networks (RINs) abstract protein structure into a series of nodes (representing residues) and edges (representing connections between residues likely to interact). Analyzing the RINs of monomeric forms of amyloidogenic proteins for common network features revealed similarities not previously known. First, amyloidogenic variants of lysozyme were used to demonstrate the usefulness of RINs to the study of amyloidogenic …

Examining The Associative Learning And Accumbal Dopaminergic Mechanisms Of Caffeine Reinforcement, Curtis Bradley

Electronic Theses and Dissertations

Caffeine is the most consumed psychoactive substance in the world, and most caffeine consumption in coffee and energy drinks is intended to produce a psychoactive effect. However, caffeine is not a primary reinforcer in preclinical paradigms – non-human species do not reliably take the drug to produce a psychoactive effect. However, caffeine is a ‘reinforcement enhancer’ in preclinical models; the effects of caffeine increase the motivation to obtain other non-drug reinforcers. The overall goal of this project was to determine if these reinforcement enhancing effects of caffeine could promote caffeine self-administration and to subsequently investigate the behavioral and neurochemical underpinnings …

Distribution Of A Sum Of Random Variables When The Sample Size Is A Poisson Distribution, Mark Pfister

Electronic Theses and Dissertations

A probability distribution is a statistical function that describes the probability of possible outcomes in an experiment or occurrence. There are many different probability distributions that give the probability of an event happening, given some sample size n. An important question in statistics is to determine the distribution of the sum of independent random variables when the sample size n is fixed. For example, it is known that the sum of n independent Bernoulli random variables with success probability p is a Binomial distribution with parameters n and p: However, this is not true when the sample size …

Metabolic Plasticity In The Cellular Stress Response, Ying Li

Electronic Theses and Dissertations

Changes to the metabolism of the cardiomyocyte are driven by complex signaling pathways in order to adjust to stress. For instance, HIF-1α is classically known to upregulate glycolytic metabolism to compensate for oxygen deficiency. Other important effects upon glucose metabolism, which we investigate here more extensively, were also observed. Hearts derived from mice with the cardiac-restricted expression of a stabilized form of HIF-1α are remarkably ischemia stress-tolerant. Here, stable isotope-resolved metabolomic analyses were utilized to investigate glucose cardiometabolism remodeling by HIF-1αduring ischemia. We found that ¹³C-lactate accumulation was significantly elevated in HIF-1α expressing hearts while paradoxically glycogen was maintained …

3d-Printed Fluidic Devices And Incorporated Graphite Electrodes For Electrochemical Immunoassay Of Biomarker Proteins, Abdulhameed Alabdulwaheed

Electronic Theses and Dissertations

Biomarkers are measurable indicators of health status or disease state that can be used for diagnosis and may help guide patient treatment strategies. Enzyme-linked immunosorbent assays (ELISA) and other many clinical techniques currently used for measuring biomarker proteins lack sensitivity, demand high analysis cost, are often not well-suited for measuring multiple biomarkers in a single sample, and require long analysis times. Here, we demonstrate simple, low-cost 3D-printed flow-through devices with integrated electrodes modified with gold nanoparticles (AuNPs) for electrochemical immunoassays of S100B, a biomarker protein related to conditions like skin cancer and brain injuries. Flow-through devices are fabricated from photocurable-resin …

Fascicle Arrangement In College-Aged Athletes, Jacob Goodin

Electronic Theses and Dissertations

Purpose: To compare muscle architecture variables between sport and sex in competitive athletes, and to compare muscle architecture with performance variables in strong versus weak athletes, and good versus poor jumpers. Methods: The vastus lateralis (VL) and lateral gastrocnemius (LG) muscles of 139 collegiate athletes were collected using ultrasonography to determine muscle thickness (MT), pennation angle (PA), fascicle length (FL), and relative fascicle length (FL_rel). Absolute and relative peak power, absolute and relative isometric peak force, and jump height were measured in a subset of baseball and soccer athletes. A 5x2 factorial analysis of variance (ANOVA) was used …

Clustering Mixed Data: An Extension Of The Gower Coefficient With Weighted L2 Distance, Augustine Oppong

Electronic Theses and Dissertations

Sorting out data into partitions is increasing becoming complex as the constituents of data is growing outward everyday. Mixed data comprises continuous, categorical, directional functional and other types of variables. Clustering mixed data is based on special dissimilarities of the variables. Some data types may influence the clustering solution. Assigning appropriate weight to the functional data may improve the performance of the clustering algorithm. In this paper we use the extension of the Gower coefficient with judciously chosen weight for the L2 to cluster mixed data.The benefits of weighting are demonstrated both in in applications to the Buoy data set …

Post-Transcriptional Regulation Of Rsma In Pseudomonas Aeruginosa, Ian Miller

Electronic Theses and Dissertations

Pseudomonas aeruginosa is a Gram-negative bacillus found in numerous environments. Gene regulatory mechanisms such as; Two-Component Systems, transcriptional and post-transcriptional regulators, and small non-coding RNAs control the expression of virulence factors that allow P. aeruginosa to initiate acute infections and persist as a chronic infection. A significant post-transcriptional regulator involved in these regulatory networks is the Regulator of Secondary Metabolites (RsmA). In this study, we investigated the contribution of a putative stem-loop on expression of RsmA. We constructed rsmA leader fusions to measure translation with and without the stem-loop present. Secondly, we introduced point mutations to disrupt the formation …

Hydrodynamic Drivers Of Dissolved Oxygen Variability Within A Highly Developed Tidal Creek In Myrtle Beach, South Carolina, Douglas Matthew Pastore

Electronic Theses and Dissertations

Erosion and water quality degradation have been observed in Singleton Swash in Myrtle Beach, SC, and have been hypothesized to be related to migration of the beach-face channel. Dredging this channel temporarily fixes erosional threats to nearby infrastructure but the effects on water quality are not well understood. It is hypothesized that variations in dissolved oxygen (DO) concentration (used here as a proxy for water quality) within the water column are related to changes in vertical mixing and transport due to oceanic tidal forcing. This study utilizes current meters, pressure sensors, and optical DO probes to measure and study the …

Seasonal Occurrence, Relative Abundance, And Migratory Movements Of Juvenile Sandbar Sharks, Carcharhinus Plumbeus, In Winyah Bay, South Carolina, Caroline Collatos

Electronic Theses and Dissertations

Winyah Bay, located on the coast of South Carolina, is the fourth largest U.S. estuary by discharge rate (Voulgaris et al. 2002), and provides an annually used habitat for juvenile C. plumbeus (Abel et al. 2006, Gary 2009). From May to September 2016 and 2017, we set a total of 303 bottom longlines in middle and lower Winyah Bay to assess sex ratios, size distributions, and catch per unit effort (CPUE), as well as the potential influence of abiotic parameters on CPUE. A subset of eleven juvenile C. plumbeus was tagged with VEMCO (V16-4H) acoustic transmitters to analyze seasonal occurrence, …

Semi-Quantitative Assessment On Winyah Bay's Microplastic Contamination Levels, Samantha Ladewig

Electronic Theses and Dissertations

Although there is much concern globally regarding microplastic contamination in aquatic environments, there is little documentation on microplastic contamination concentrations within South Carolina inland waters and coastal areas. Specifically, Winyah Bay, SC should be of high priority for microplastic contamination evaluations as it is the third largest drainage basin (47,060 km2) and the second largest (157 km2) estuarine system on the east coast of the United States. Today, the general influencing physical factors on microplastic transport are mostly known by the scientific community, however, transport and deposition patterns of microplastics heavily vary by location depending on various physical, chemical, and …

Characterization Of A Turbulent Boundary Layer In Open Channel Flow Using Particle Image Velocimetry, Mathew James Stanek

Electronic Theses and Dissertations

Turbulent boundary layers are influential in numerous applications (e.g. naval architecture, ocean engineering, sediment transport, etc.), yet considerable knowledge gaps still exist. Boundary layers are regions where transfer of mass, momentum, energy, and heat occur within the interface between a fluid and a solid, or between two fluids. Utilization of optical flow measurement techniques to measure the velocity field with high spatial resolution enables non-intrusive investigation of the complex fluid dynamics of boundary layers. In this study two-dimensional Particle Image Velocimetry was employed to investigate, primarily, the overlap layer of a turbulent boundary layer developed in the recirculating flume facility …

Hardbottom Characterization And Relationship To The Geologic Framework In Long Bay, South Carolina, Cathryn J. Wheaton

Electronic Theses and Dissertations

Hardbottom seafloor is a common element among sediment-starved portions of the inner continental shelf along the U.S. Atlantic margin. These areas are characterized by indurated sediment surfaces that are heavily altered by biological and physical processes. Long Bay, in northeastern South Carolina, offers ideal environmental conditions for hardbottom exposure with only patchy Holocene sand deposits, interspersed with extensive hardbottom areas. Here we use high-resolution multibeam bathymetry, CHIRP subbottom profiling and electrical resistivity data, along with surficial sediment samples, hardbottom thin sections, and water column radioisotope (radon-222) analysis to investigate the origin and geologic framework of a region of hardbottom seafloor …

Unique Osmoregulatory Morphology In Primitive Sharks: An Intermediate State Between Holocephalan And Derived Shark Secretory Morphology, Matthew Eric Larsen

Electronic Theses and Dissertations

Discovery of an unusual rectal gland in the Atlantic sixgill shark, Hexanchus vitulus, led to examination of rectal glands in 29 species of epipelagic and deep-sea sharks. Eight of 14 deep-sea species of sharks had digitiform glands that were previously assumed to be characteristic of elasmobranchs (N=281; mean width-length ratio ± SD = 0.18 ± 0.07). Hematoxylin-and-eosin stained sections from deep-sea sharks were similar to those from shallow water sharks. Glands from the family Somniosidae were kidney bean-shaped (N = 3; mean width-length ratio ± SD = 0.46 ± 0.05); whereas those from the families Echinorhinidae and Hexanchidae appeared lobulate …

The Effectiveness Of Localized Ultrasound And Aptamer Surface Modification On Nanoemulsions For Drug Delivery To Spheroids., Daniel A. Hodge

Electronic Theses and Dissertations

Cancer is a group of diseases that affects 1.6 million and kills nearly 600,000 Americans each year. The National Cancer Institute defines it as “diseases in which abnormal cells divide without control and can invade nearby tissues” and it is often treated with one or more of the following: chemotherapy, radiation, surgery. The expense for these treatments is expected to rise to $156 billion by 2020. Localized delivery can improve effectiveness and cancer survival rates, decrease the cost of treatment, and decrease the side effects of chemotherapy. This paper addresses models for this localized delivery through nanoemulsions. Nanoemulsions are a …

The Association Between Medication Adherence In Mental Illness And Substance Use Disorder Relapse In Patients With Dual Diagnosis, Tyler Dunn

Electronic Theses and Dissertations

Objectives: The aims of the study were to (1) identify personal, social, and clinical history for patients with substance use disorder (SUD) and mental illness, (2) measure agreeance between patient self-report versus facility record history for mental illness, substance abuse, and psychotropic medication, (3) investigate the specific role of medication adherence and barriers to use for psychotropic medications upon SUD relapse, and (4) assess follow-up changes in mental illness severity and medication adherence in dual diagnosis patients enrolled in a substance abuse rehabilitation program.

Methods: The pilot study utilized a mixed methodology. Inclusion criteria included male patients at least 18 …

The Effect Of Compound L19 On Human Colorectal Cells (Dld-1), Sepideh Mohammadhosseinpour

Electronic Theses and Dissertations

Colorectal cancer is the third most common type of cancer in the world and the second leading cause of death among humans. Extracts of water soluble compounds from the roots and leaves of Rumex crispus were screened for compounds that induced apoptosis in DLD-1 cells. A compound referred to as L19 was isolated using Accelerated Solvent Extraction (ASE) followed by High Performance Liquid Chromatography (HPLC). Gas chromatography coupled with mass spectrometry was used to identify the L19 as a tetrahydrofuran with a molecular weight of 72.11 g/mole. Each HPLC fraction resulted in 94.4% purity. In the present research, specific genes …

A Sexual Assault Prevention Program Proposal For Abilene Christian University, Ammie Brooks, Ammie Kae Brooks

Electronic Theses and Dissertations

The purpose of this study is to develop the most effective sexual assault prevention

program for Abilene Christian University. The program will meet the federal regulation requiring Universities to participate in sexual assault prevention and education. Additionally, the program will be made to fit the audience at Abilene Christian University. The proposed program is designed to encompass all undergraduate students at Abilene Christian University and use a pretest and posttest to measure the effectives of the program to meet its eight predetermined goals. The following paper presents the program proposal, methodology and evaluation tools needed for its future implementation.

Initial Assessment Of Canopy Fuel Factors In Forested Areas Of The Netherlands, Alan Hibler

Electronic Theses and Dissertations

The changing climate in the Netherlands has created the need to better understand how the forested communities and their structures will be affected by fire and to better estimate the impact of those fires. This study is part of a continuing collaboration between the Stephen F. Austin State University’s Arthur Temple College of Forestry and Agriculture and the Instittut Fysieke Veiligheid to assess fuel loads in the Netherlands to develop and improve models to estimate fire behavior. Data to estimate canopy bulk density for modelling canopy fire behavior were collected in the Netherlands for Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco), …

The Challenges Of Newly Adopted Mathematics Curriculum In Title I Schools: A Mixed Methods Study, Carmen Cruz

Electronic Theses and Dissertations

The purpose of this mixed methods study was to examine the early impacts of the newly adopted mathematics TEKS (Texas Essential Knowledge Skills) introduced in 2014 by TEA (Texas Education Agency) that detail the curriculum standards for all students across schools in Texas schools, for grades K-12. The study examined the challenges that teachers and administrators have had to overcome to meet federal legislation educational compliance. Additionally the study examined how schools and districts were professionally developing their teachers on new curricular standards. Five Title 1 schools in four school districts were used in the study. Schools were selected from …

Effects Of One Neurofeedback Session On Relationship Between Fear-Of-Pain And Visual Avoidance Of Pain, Timothy Swift

Electronic Theses and Dissertations

Chronic pain is increasingly prevalent and costly and will continue to be with the increasing mean age of America’s population. It is important to identify interventions addressing pain-related biopsychosocial aspects. The purpose of the current study was to examine if a single session of specific neurofeedback (NF) protocols had an effect on subjective fear and physiological fear-avoidance behaviors in relation to pain-related stimuli. Correlational analyses revealed that FPQ-III minor pain scores were negatively associated with total fixation duration while looking at pain-related pictures. One-way ANOVAs revealed differences approaching significance for those trained on Left-Hemisphere NF protocols compared to those in …

Environmental Assessment Of Road Brining And Injection Wells For Disposal Of Oil And Gas Liquid Waste, Marissa Madia

Electronic Theses and Dissertations

The dramatic increase in oil and gas drilling operations in Pennsylvania over the last decade has presented a challenge for their wastewater disposal (e.g., flowback, produced water). Currently, these fluids are treated in permitted brine treatment plants or exported out of state to deep injection well facilities. In Pennsylvania, road brining for dust control is permitted for conventional well brines, and permits for three injection wells for unconventional brines are pending. This study focused on water quality impacts due to road brining in Farmington Township (45 samples) and ground and surface water in Grant Township (41 samples) prior to the …

Explaining The Obvious: Privileged Hermeneutics And The Irony Of Explicitly Literal Interpretation, Joshua Alkire

Electronic Theses and Dissertations

The purpose of this thesis is to examine why so many uses of the word literal (whether taken from everyday contemporary speech or the works of well-respected ancient writers) seem at odds with the word’s theoretical definition and to explore the implications of this disparity for those who privilege a literal interpretation of Scripture. The examples will show that the meaning of literal was not altered at a particular point in time, nor is it altered on an ongoing basis by a small subset of particularly idiosyncratic individuals. Rather, the word is predisposed to behave strangely the moment it is …

The Impact Of Media On The Public's Perception Of Texas Foster Care, Hannah Sims

Electronic Theses and Dissertations

This study explores if valid information can mitigate stereotypes of foster care as reflected in popular media, specifically in the context of the State of Texas. A quasiexperimental, post-test only design assessed the role that media plays in the public’s perception of foster care in the state of Texas. Results indicate that media, in the form of a professional presentation, made statistically significant differences between treatment and control groups in regard to the overall perception and general attitudes towards the foster care system in the State of Texas. Results indicate the need for further research in the area of media’s …

Toward A New Reading Of Cicero's De Finibus, Kelsey Ward

Electronic Theses and Dissertations

In this dissertation, I argue that Cicero has two primary, interdependent aims in De finibus: the critical assessment of the dominant ethical positions, and the education of his readers. These aims are accomplished through four key devices. First, Cicero develops flat, useful readings of the dominant ethical positions without rejecting eudaimonism itself. This allows Cicero to demonstrate Academic practices while also insisting upon the importance of virtue, which suggests the best ethical view for Cicero is a skeptically grounded eudaimonism. Second, the arrangement of the text in reverse chronological order dramatically enacts Cicero’s own alternative to the cradle argument on …

The Rhetoric Of The Opioid Crisis And Addiction To Prescription Pain Medicine, Rachel Kaplan

Electronic Theses and Dissertations

In this historical moment, the United States is amidst an opioid crisis killing the young and the old; at least seventy-eight people die every day from an opioid-related overdose (Enomoto in Murthy III). Changing mindsets of the doctors who prescribe opioids is just as important as asking the patients who are prescribed them to demand an alternative medication. The different parties involved in the crisis all have a different agenda and their rhetorical bias is explored throughout this project. The pharmaceutical companies have launched aggressive marketing campaigns expressing the benefits of opioids and encouraged physicians to prescribe, the CDC has …

Melatonin-Micronutrients Osteopenia Treatment Study (Mots): A Translational Study Assessing The Effects Of Melatonin, Strontium Citrate, Vitamin D3 And Vitamin K2 On Bone Density, Bone Turnover Markers And Health-Related Quality Of Life In Postmenopausal Osteopenic Women Following A One-Year Double-Blind Randomized Placebo-Controlled Trial And On Osteoblast-Osteoclast Co-Cultures, Sifat Maria

Electronic Theses and Dissertations

Objective: The purpose of this study was to assess if a novel combination of melatonin and three other natural bone-aiding micronutrients: strontium citrate, vitamins D₃ and K₂ (MSDK) could improve bone health by modulating the activity of osteoblasts and osteoclasts in favor of balanced bone remodeling and by improving the overall health-related quality of life in postmenopausal osteopenic women.

Methods: The Melatonin-micronutrients Osteopenia Treatment Study (MOTS) is a translational research study that used both clinical and in vitro approaches to assess the efficacy of MSDK on bone health in women and to identify potential mechanisms for its effects. …

H. Odera Oruka And The Right To A Human Minimum: A Sagacious Quest For Global Justice, Michael Kamau Mburu

Electronic Theses and Dissertations

This dissertation primarily aims at making contribution to the advancement of philosophy from the practical point of view. It does so by analytically and critically studying H. Odera Oruka (1944-1995), arguably one of the finest 20^th century African philosophers. Thus, it identifies, expounds, and critiques Oruka’s philosophical cum ethical commitment by situating him within various philosophical discourses touching such important global issues as justice, human rights, ethical duty, ecology, humanism and politics. It specifically advances Oruka’s argument for the right to a human minimum, establishing how that ethical principle can be applicable in addressing some distressing human conditions …