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A Novel Approach To Hiv Prevention: Understanding Multi-Level Influences On Hiv Pre-Exposure Prophylaxis (Prep) Uptake And Outreach Among African Americans., Suur Debrah Ayangeakaa May 2020

A Novel Approach To Hiv Prevention: Understanding Multi-Level Influences On Hiv Pre-Exposure Prophylaxis (Prep) Uptake And Outreach Among African Americans., Suur Debrah Ayangeakaa

Electronic Theses and Dissertations

This dissertation examined and provided basis for addressing factors related to HIV pre-exposure prophylaxis (PrEP) engagement, outreach, and uptake among high-risk African American youth groups in Louisville, KY. This qualitative dissertation study was designed through the lens of an interpretive framework of social constructivism which holds that multiple realities and interpretations exist and are socially constructed through the lived experiences of individuals and their interactions with others. Thus, lived experiences of various African American youth groups in Louisville as well as key informants of AIDS service organizations (ASOs) across the U.S. (including Louisville) were explored to develop a deeper understanding …

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Tobacco Product-Derived Aldehydes: Effects On Circulating Angiogenic Cells & Implications For Cardiovascular Disease., Jordan B. Lynch May 2020

Tobacco Product-Derived Aldehydes: Effects On Circulating Angiogenic Cells & Implications For Cardiovascular Disease., Jordan B. Lynch

Electronic Theses and Dissertations

Cardiovascular disease (CVD) is the leading cause of death worldwide. Tobacco smoke is the most significant modifiable risk factor in CVD development and contains numerous toxic compounds, including aldehydes, which have been linked to CVD. Formaldehyde, acetaldehyde, acrolein, and crotonaldehyde have been identified as significant contributors to cigarette-induced health effects, but the mechanism of these effects is not well understood. These aldehydes are also found in aerosols produced by e-cigarettes (e-cigs). The goal of this dissertation was to explore the systemic, hematological, and endothelium-related effects of exposure to tobacco products and constituent aldehydes and to identify potential mechanisms of injury. …

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Development Of Rationally Designed Live Attenuated Vaccines For Lassa Fever And Venezuelan Equine Encephalitis., Dylan Macgregor Johnson May 2020

Development Of Rationally Designed Live Attenuated Vaccines For Lassa Fever And Venezuelan Equine Encephalitis., Dylan Macgregor Johnson

Electronic Theses and Dissertations

Lassa Virus (LASV) and Venezuelan Equine Encephalitis Virus (VEEV) are two single stranded RNA viruses belonging to the Arenavirus and Alphavirus families, respectively. Both are emerging pathogens without approved vaccines or treatments. VEEV is an important biothreat pathogen because it has been weaponized and is extremely infectious as an aerosol. VEEV causes biphasic febrile illness that can progress to a viral encephalitis with low mortality, but high morbidity. LASV causes a viral hemorrhagic fever, Lassa Fever (LF), which is endemic in West Africa, and responsible for between 100-500k annual infections with a 1-2% overall mortality rate. ML29 and VEEV TC-83 …

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Role Of Plant Volatile Organic Compounds (Vocs) In Seed Priming And Plant-Herbivore Interactions., Abhinav Kumar Maurya May 2020

Role Of Plant Volatile Organic Compounds (Vocs) In Seed Priming And Plant-Herbivore Interactions., Abhinav Kumar Maurya

Electronic Theses and Dissertations

This dissertation explores and expands the existing knowledge on the role of plant volatiles in facilitating seed priming and providing direct defense against herbivore. Although the roles of plant volatiles in priming a plant’s defenses and providing direct defense against pests is well known, information regarding their effects on seed and the fitness of future plants and direct toxicity to herbivores is understudied. This dissertation does a thorough examination of these two understudied aspects of plant volatiles and provides novel insight into the role of plant volatiles in seed priming and direct defense (Chapter I). Seeds in the soil can …

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Mechanistic Insight Of The Role Of Nherf1 In Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle May 2020

Mechanistic Insight Of The Role Of Nherf1 In Cisplatin-Induced Acute Kidney Injury., Adrienne M. Bushau-Sprinkle

Electronic Theses and Dissertations

Background. Acute kidney injury (AKI) develops in 30% of patients who receive cisplatin, a widely used chemotherapeutic agent. We previously showed that NHERF1 loss resulted in increased susceptibility to cisplatin nephrotoxicity. The overarching goal of this dissertation was to elucidate mechanisms of susceptibility to cisplatin-induced AKI, specifically the effects of NHERF1 loss on tubule cell metabolism, tubule cell mitochondrial function, and alterations in oxidative state and/or renal handling of cisplatin. Methods. 2-4 month male wild type (WT) and NHERF1 knock out (KO) mice were treated with either vehicle control or cisplatin (20 mg/kg dose IP) for 4, 24, and 72 …

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The Retinoblastoma Protein Mediates Metabolic Reprogramming In Lung Cancer., Lindsey R. Conroy May 2020

The Retinoblastoma Protein Mediates Metabolic Reprogramming In Lung Cancer., Lindsey R. Conroy

Electronic Theses and Dissertations

Lung cancer is among the most frequently diagnosed cancers and is the leading cause of cancer-related deaths worldwide. One of the hallmark events in lung cancer pathogenesis is deregulation of the cell cycle. The retinoblastoma protein (pRb) is a tumor suppressor that is deleted, mutated, or inactivated in most lung cancer cases. Canonically, pRb functions to regulate cell cycle progression by repressing the transcriptional activity of the E2F family of transcription factors, inhibiting S phase entry. Although the cell cycle functions of pRb have been well established, recent studies have highlighted a functional role for pRb in controlling cellular metabolism. …

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Examining Corporate Blameworthiness In Relation To Federal Organizational Sentencing For Probation And Corporate Monitors., Emily M. Homer May 2020

Examining Corporate Blameworthiness In Relation To Federal Organizational Sentencing For Probation And Corporate Monitors., Emily M. Homer

Electronic Theses and Dissertations

Organizations that have benefitted from the commission of federal crimes committed by their employees may be sentenced to federal criminal penalties. Two of these potential penalties include probation and the requirement to implement a corporate monitor. The federal guidelines provide suggestions for sentencing probation that echo the theoretical focal concern of blameworthiness. This research used eight years of United States Sentencing Commission data covering 2011 to 2018 (n= 1,224) to examine if organizations were being sentenced to probation and monitoring consistent with the federal guidelines and focal concern of blameworthiness. The study examined nine potential measures of blameworthiness …

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Susceptibility Assessment Of Bank And Floodplain Erosion In Stream Restoration Using A Two-Dimensional Hydrodynamic., Fereshteh Noorbakhsh May 2020

Susceptibility Assessment Of Bank And Floodplain Erosion In Stream Restoration Using A Two-Dimensional Hydrodynamic., Fereshteh Noorbakhsh

Electronic Theses and Dissertations

In the design of stream restorations, boundary shear stress (shear stress) and velocity during high flow events are the key parameters in the assessment of the risk of morphological failure associated with channel bank and bed erosion and sediment transport. The use of two-dimensional hydrodynamic models (2D Models) is becoming more common to estimate critical shear stress and velocity for stream restoration projects. These models can give detailed distribution of shear stress and velocity over floodplain surfaces and channel. Obtaining reliable and correct estimates of stress and velocity require an accurate digital terrain model, estimates of input flows at the …

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Identifying Protective Factors Against Overweight And Obesity Within The Social Environment Of Women With Low Incomes., Monica M. Adams May 2020

Identifying Protective Factors Against Overweight And Obesity Within The Social Environment Of Women With Low Incomes., Monica M. Adams

Electronic Theses and Dissertations

Over two-thirds of the United States population have overweight or obese (OW/OB) weight statuses due in large part to an obesogenic environment that encourages unhealthful weight related behaviors. The obesogenic environment appears to place a larger burden on women with low incomes as they experience OW/OB disproportionately compared to other groups. Studies seeking to understand the impact of the obesogenic environment on this population have been deficit focused, largely examining environmental risk factors for OW/OB and ignoring protective factors against it. Most women with low incomes do not have an obese weight status and some women who have OW/OB statuses …

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Modulation Of Host Innate Immune Cells By Yersinia Pestis To Create A Permissive Environment For Replication., Amanda Rose Pulsifer May 2020

Modulation Of Host Innate Immune Cells By Yersinia Pestis To Create A Permissive Environment For Replication., Amanda Rose Pulsifer

Electronic Theses and Dissertations

Yersinia pestis has gained widespread infamy due to the historic outbreak during the middle ages, referred to as The Black Death. Infection with Y. pestis typically begins with deposition of Y. pestis into the dermis (bubonic plague) or respiratory tract (pneumonic plague). Tissue resident macrophages are the first innate immune cell encountered by Y. pestis. Macrophages are likely a way for Y. pestis to avoid neutrophils early in infection when the neutrophil neutralizing Type Three Secretion System is not expressed. This work focuses on which Rab host proteins are manipulated by Y. pestis, and how neutrophils are forced to …

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The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina May 2020

The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina

Electronic Theses and Dissertations

Periodontitis is an irreversible, chronic inflammatory disease where pathogenic microbial communities accumulate in the gingival crevice. Advances in culture-independent techniques have facilitated the identification of new bacterial species in periodontal lesions, such as the Gram-positive anaerobe, Filifactor alocis. Neutrophils are a major component of the innate host response, and the outcome of their interaction with F. alocis may be a determinant of oral health status. While neutrophil functions typically protect the host against periodontal disease, oral pathogens have adapted to evade or disarm neutrophil microbicidal functions while promoting mechanisms that drive inflammation, which also provides a source of nutrients …

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Tobacco Smoke Exposures And Fertility-Related Outcomes Among Females Seeking Fertility Care, And The Interaction With N-Acetyltransferase 2 (Nat2).., T'Shura S. A. Ali May 2020

Tobacco Smoke Exposures And Fertility-Related Outcomes Among Females Seeking Fertility Care, And The Interaction With N-Acetyltransferase 2 (Nat2).., T'Shura S. A. Ali

Electronic Theses and Dissertations

Cigarette smoke contains thousands of harmful substances and is one of the leading preventable causes of mortality and morbidity in the United States. Past studies examining tobacco smoke exposures on fecundability and pregnancy outcomes are inconsistent. NAT2 is an important enzyme in the metabolism of xenobiotic substances found within tobacco smoke. This preconception cohort study examines associations between active smoking and secondhand smoke exposure (SHSe) on fecundability and spontaneous abortion (SA), and explores a possible interaction with NAT2 acetylator status. A total of 223 women seeking fertility care were followed for up to 2.3 years. Preconception tobacco smoke exposures were …

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Aboveground-Belowground Interactions: Roles Of Soil Biotic And Abiotic Factors On Switchgrass's (Panicum Virgatum) Growth, Defense Against Herbivory And Cell Wall Chemistry., Binod Basyal May 2020

Aboveground-Belowground Interactions: Roles Of Soil Biotic And Abiotic Factors On Switchgrass's (Panicum Virgatum) Growth, Defense Against Herbivory And Cell Wall Chemistry., Binod Basyal

Electronic Theses and Dissertations

Plants constantly interact with their biotic and abiotic soil environments. Most terrestrial plants form beneficial associations with soil microbes such as arbuscular mycorrhizal (AM) fungi, which are widely known for their ability to transfer soil phosphorus and nitrogen to the host plants. They help plants tolerate drought stress and improve plant defense against herbivores such as plant-parasitic nematodes (PPNs). This dissertation investigates the role of AM fungi on switchgrass’s (Panicum virgatum) growth, cell wall chemistry, and defense against PPNs using a combination of growth chamber and field studies. Switchgrass is a native warm-season species which is gaining traction as candidate …

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Glare Reduction By Dark Facial Markings And Bills In Birds, Clara Lebow May 2020

Glare Reduction By Dark Facial Markings And Bills In Birds, Clara Lebow

Electronic Theses and Dissertations

Avian facial plumage, bill coloration, and feather microstructure may serve one or more adaptive functions. Several researchers have proposed that dark eyestripes, bills, and facial masks aid in reducing glare, however, there have been relatively few tests of this hypothesis. Dark facial markings have been shown to have an adaptive glare-reduction function in recent field studies of a few species, but this hypothesis has never been tested in a broad multispecies analysis. It is likely that feather microstructure influences feather brightness and has an effect on the efficacy of glare reduction properties of feathers. I examined the link between dark …

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Effects Of Increased Atmospheric Carbon Dioxide Levels On Tobacco Mosaic Virus And Root-Knot Nematodes In Genetically Resistant And Susceptible Tomato Plants, Angie Nicholas May 2020

Effects Of Increased Atmospheric Carbon Dioxide Levels On Tobacco Mosaic Virus And Root-Knot Nematodes In Genetically Resistant And Susceptible Tomato Plants, Angie Nicholas

Electronic Theses and Dissertations

Rising atmospheric carbon dioxide (CO2) may affect plant/pathogen interactions. This study focused on the effects of elevated CO2 on Root-Knot Nematode (Meloidogyne arenaria) and Tobacco Mosaic Virus (TMV) infection in genetically resistant versus susceptible tomatoes (Solanum lycopersicum). Both resistant and susceptible tomatoes were grown in chambers with either ambient CO2 or CO2 elevated to 750 ppm and infected with M. arenaria or TMV. Measurements were taken at regular intervals to determine the effects of the pathogens on the plants. Resistant plants infected with M. arenaria maintained resistance while susceptible plants remained …

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Effects Of Pre-Workout Caffeine Supplementation On Post-Exercise Hypotension, Shelby L. Gibbs May 2020

Effects Of Pre-Workout Caffeine Supplementation On Post-Exercise Hypotension, Shelby L. Gibbs

Electronic Theses and Dissertations

Post-exercise hypotension (PEH) is believed to play a major role in the antihypertensive health benefits of exercise. While it has been shown that resistance exercise is effective at eliciting PEH, commonly consumed sports supplements may attenuate or completely eliminate that response. Caffeine, a popular stimulant, is often consumed prior to exercise. Therefore, the purpose of this study was to investigate the effects of pre-workout caffeine supplementation on the post-exercise hypotensive response in adults with above normal blood pressure. Participants (n = 5) were recreationally resistance trained men and women who consumed placebo or caffeine (3 mg/kg bodyweight) 45-minutes prior to …

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Evaluation Of Metal Concentration In Water And Soil In The Southern Region Of Lake Nacogdoches, Olawunmi Taiwo May 2020

Evaluation Of Metal Concentration In Water And Soil In The Southern Region Of Lake Nacogdoches, Olawunmi Taiwo

Electronic Theses and Dissertations

The concentrations of metals (Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, V, Zn) were investigated in soil and water samples collected over four different sites in the southern part of Lake Nacogdoches over one year from August 2018 through June 2019. Water samples were analyzed using the USEPA method 200.8 part 11.2 for total recoverable metals. Soil samples were analyzed using the USEPA method 3050B for total recoverable metals. Although the total concentration gives some indication of the level of contamination, it is not enough to give information on the bioavailability or mobility of the element. A modified …

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Quality Of Life Of Adults Who Have Attempted Suicide, Karen Hoefer May 2020

Quality Of Life Of Adults Who Have Attempted Suicide, Karen Hoefer

Electronic Theses and Dissertations

This study focuses on the quality of life of suicide attempt survivors and the trajectories of their lives after their last attempt in the past two to ten years. Employing both a quantitative and qualitative approach but focusing largely on the qualitative data, I collected demographic data, gathered responses on an abbreviated Reasons for Living Inventory, and conducted open-ended phone interviews with 26 participants. The primary life course finding is that participants’ suicide attempts are often built on years of dealing with mental illness. The analysis also dispels many stereotypes associated with people who have attempted suicide. I explore patterns …

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Synthesis And Characterization Of Carbon Monoxide Producers Bipyridine Flavonolate Palladium(Ii) And Platinum(Ii) Complexes: Potential Anti-Cancer Agents, Sarah Whitfield May 2020

Synthesis And Characterization Of Carbon Monoxide Producers Bipyridine Flavonolate Palladium(Ii) And Platinum(Ii) Complexes: Potential Anti-Cancer Agents, Sarah Whitfield

Electronic Theses and Dissertations

Novel designed metal ligand complexes as prodrugs are useful in the effort to find more effective and selective anti-cancer treatments. Carbon monoxide, CO, is known to induce mitochondrial collapse in cancer cells. Herein is described the synthesis of seven novel bipyridine flavonolate palladium(II) and platinum(II) complexes with the property of releasing carbon monoxide, and their characterization with FTIR, UV-Vis, fluorescence, NMR, and ESI mass spectra. Their ability to release carbon monoxide was investigated through oxygenation reaction under various conditions of temperature and light irradiation. The nitroxygenation reaction of the palladium complexes was also studied with nitrosyl hydride, HNO, generated in …

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A Novel Mathematical Model Of The Trojan Y-Chromosome Strategy With Optimal Control, Christopher Turner May 2020

A Novel Mathematical Model Of The Trojan Y-Chromosome Strategy With Optimal Control, Christopher Turner

Electronic Theses and Dissertations

Invasive species are a prevalent problem all over the world. Controlling and eradicating an invasive species is an even more diffcult problem. The Trojan Y Chromosome (TYC) eradication strategy is one control method. This method alters the female to male sex ratio by introducing sex reversed males called supermales. These sex reversed males can only produce male progeny. Mathematical models of this strategy have shown that a population can be driven to extinction with a continuous supply of these sex reversed males. There are many different mathematical models of this strategy, but most have serious flaws, such as negative solutions …

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The Benefits Of Alternative Therapies On Adult Mental Health, Sara Bryan May 2020

The Benefits Of Alternative Therapies On Adult Mental Health, Sara Bryan

Electronic Theses and Dissertations

The purpose of the following descriptive pre and post study was to collect and analyze data to determine if there are benefits to alternative therapies on adult mental health. Three types of alternative therapies were studied: aromatherapy, recreation therapy, and yoga. A literature review was conducted and pre and post questionnaires were administered. Frequencies and averages were run which showed that participants were mostly Caucasian, with an average age of 31 years and most diagnosed with depression and anxiety. Participants showed decreased levels of anxiety and depression after attending both aromatherapy and yoga classes. Participants showed decreased anxiety levels after …

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Portrait Of Modern Pluralism: A Practitioner's Perspective On Interest Group Politics And Theory., Mary Ellen Wiederwohl May 2020

Portrait Of Modern Pluralism: A Practitioner's Perspective On Interest Group Politics And Theory., Mary Ellen Wiederwohl

Electronic Theses and Dissertations

This thesis presents a practitioner’s view on interest groups and interest group theory based primarily on Mancur Olson’s conclusions that small, organized minority interests have an advantage over the large, disorganized majority interests in the policymaking process; it tests the “why” behind this theory through an examination of a variety of factors, including the influence of money, the power of communications tools deployed by these interests, and the lobbyists’ role. It includes an introduction plus four chapters, including literature review, research methods, participant observations and in-depth interviews, and conclusion. The research methods included primarily participant observation based on a two-decade …

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Exosomes From Embryonic Stem Cells As A Prophylactic Vaccine Against Lung Cancer., Shuhan Meng May 2020

Exosomes From Embryonic Stem Cells As A Prophylactic Vaccine Against Lung Cancer., Shuhan Meng

Electronic Theses and Dissertations

The antigenic similarity between embryos and tumors has raised the idea of using embryonic materials as a preventative vaccine against neoplastic disease. Indeed, a previous study reported that a vaccine comprised of allogeneic murine embryonic stem cells (ESCs) and murine fibroblasts expressing immune-stimulatory granulocyte macrophage-colony stimulating factor (GM-CSF) successfully blocked the outgrowth of an implantable lung cancer (Lewis lung carcinoma; LLC) and lung tumors caused by a combination of a mutagen followed by chronic pulmonary inflammation. However, such a vaccine is obviously impractical for application to humans. The use of fibroblasts to produce GM-CSF is needlessly complicated, and intact live …

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Development Of In Vitro Models To Study The Rapid Extraintestinal Dissemination Of Salmonella., Adarsh Gopinath May 2020

Development Of In Vitro Models To Study The Rapid Extraintestinal Dissemination Of Salmonella., Adarsh Gopinath

Electronic Theses and Dissertations

Salmonella appears in the bloodstream of mice in as little as 15 minutes after oral inoculation and establishes persistent colonies in the spleen and liver. While its pathway to blood is undetermined, this phenomenon is dependent on the activity of Salmonella pathogenicity island 2 (SPI-2) coded type III secretion system (T3SS) and CD18+ phagocytes. We hypothesize that dendritic cells associated with the basal face of the gut epithelium, that are naturally migratory and known to sample for luminal antigens directly transport Salmonella to the bloodstream. This process comprises of at least two phases, dissociation and reverse transmigration. We define dissociation …

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Coparenting And School Success: Perspectives Of Fathers., Shannon M. Mount May 2020

Coparenting And School Success: Perspectives Of Fathers., Shannon M. Mount

Electronic Theses and Dissertations

Historically, measures of coparenting have been reported by mothers. As a result, fathers’ perspectives and experiences have largely been excluded from this body of research. In response, this study relies on fathers own report of coparenting support. This study used a sample of 1255 biological fathers from the Fragile Families and Child Wellbeing Study (FFCWS) to explore fathers’ reports of their coparenting support and how this is associated with relationship status with mother, time spent with child, and several school success variables including: internalizing and externalizing school behaviors and math and reading assessment scores at child age 9. Hypotheses included …

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Reactive And Regulative Temperament Dimensions, Emotion Regulation, And Concurrent Internalizing And Externalizing Pathology Among Youth With Adhd., Kirsten D. Leaberry May 2020

Reactive And Regulative Temperament Dimensions, Emotion Regulation, And Concurrent Internalizing And Externalizing Pathology Among Youth With Adhd., Kirsten D. Leaberry

Electronic Theses and Dissertations

Emerging research has increasingly identified the detrimental effect of internalizing and externalizing comorbidity on the functioning of youth with Attention-Deficit/Hyperactivity Disorder (ADHD). Research in the broad child psychopathology literature has identified a variety of dispositional and developmental risk factors for psychopathology development in youth. However, a conceptual model of psychopathology development has yet to be developed and empirically evaluated in an ADHD sample. Children with ADHD may be particularly vulnerable to exhibiting high rates of psychopathology, given deficits in self-regulation prevalent in this population. The current study proposed and evaluated a theoretical model of distal and proximal risk factors for …

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Functionalizing Nanoparticles With Cafa Protein To Target Bar Peptide For Oral Delivery Applications., Hetal Desai May 2020

Functionalizing Nanoparticles With Cafa Protein To Target Bar Peptide For Oral Delivery Applications., Hetal Desai

Electronic Theses and Dissertations

Background: Porphyromonas gingivalis adherence to Streptococcus gordonii may be important for P. gingivalis colonization in the oral cavity. Nanoparticles encapsulating synthetic peptide BAR (BAR-NPs) inhibit P. gingivalis adherence more potently than free BAR. However, BAR-NPs would exhibit low retention in an open flow environment. Hypothesis: Targeting BAR-NPs to the streptococcal surface using CafA protein will enhance their efficacy. Methods: CafA-modified NPs encapsulating BAR were synthesized using double emulsion approach. Surface binding and retention, and release kinetics of BAR from CafA-modified NPs was assessed. Functional inhibition assays were performed using dual a species biofilm. Results: CafA-modified NPs demonstrated specificity of adhesion, …

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Marriage And Cohabitation In The United States: The Effects Of Union Type On Relationship Quality., Courtney M. Lush May 2020

Marriage And Cohabitation In The United States: The Effects Of Union Type On Relationship Quality., Courtney M. Lush

Electronic Theses and Dissertations

Using national dyadic data from the 2010 Married and Cohabiting Couples (MCC) survey, I examine the effects on relationship quality of union type: “direct marriage”, “marriage after cohabiting”, “cohabitation with plans to marry”, “cohabitation with no marriage plan”. In addition, I examine whether these effects are different for men and women. Consistent with prior research, I found that cohabitors without plans to marry report the lowest levels of relationship quality and those who married directly report the highest levels of relationship quality. Also consistent with prior research, I find no gendered differences in the effect of union type on relationship …

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How Nondiscrimination Takes Root: An Examination Of Methods To Implement Statewide Nondiscrimination Legislation In Kentucky., Blake Nona Gould May 2020

How Nondiscrimination Takes Root: An Examination Of Methods To Implement Statewide Nondiscrimination Legislation In Kentucky., Blake Nona Gould

Electronic Theses and Dissertations

This research examined the numerous fairness ordinances in Kentucky’s cities for repeated trends, patterns, and practices in their language. Through the use of a cumulative case study, cases were selected from the ordinances as well as state and federal law, judicial actions, and other relevant factors from within the state. Each of the ordinances were examined for generalizability and their ability to be applied to a single, unified state nondiscrimination law that conforms with existing state and federal law. It was found that significant similarities exist between the various ordinances, though discrepancies would also need to be addressed. In the …

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Depressive Symptoms And Survival Among Lung Cancer Patients: Biomarkers And Potential Benefits Of An Ipod- And Mindfulness-Based Intervention., Chelsea J. Siwik May 2020

Depressive Symptoms And Survival Among Lung Cancer Patients: Biomarkers And Potential Benefits Of An Ipod- And Mindfulness-Based Intervention., Chelsea J. Siwik

Electronic Theses and Dissertations

Lung cancer patients experience high levels of distress, which commonly manifests as depressive symptoms. Importantly, depressive symptoms have demonstrated prognostic significance in cancer contexts, although the biological pathways by which depressive symptoms lead to poorer survival remain unclear and warrant greater attention. In addition to understanding the biological pathways by which depressive symptoms accelerate disease, identification of efficacious and effective psychological treatments for depressive symptoms are needed to improve both quality and quantity of life for cancer patients. Interventions that reduce depressive symptoms and improve downstream clinical outcomes are certainty needed; however, because many cancer patients face considerable burden, interventions …

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