Digital Commons Network^™

Living In A Gradient: The Influence Of Water Temperature Variation On Development, Settling Time And Survival Of Pallid Sturgeon Larvae In The Missouri River, Maria Elizabeth Erceg

Electronic Theses and Dissertations

Pallid Sturgeon (Scaphirhynchus albus) are a federally endangered species experiencing widespread reproduction and recruitment failures. Recruitment failure is hypothesized to be caused by habitat modifications made to the Missouri River that disrupt connectivity and alter temperature profiles downstream of constructed dams. Hypolimnetic releases from Missouri River dams affect the temperature downstream, creating colder conditions during the downstream drifting phase for dispersing larvae. Understanding the influence of water temperature changes on larval development is crucial for recovery efforts. In this study, we evaluated the effects of water temperature daily heating rate on energy use, settling behavior, and growth rate of endogenously …

Post-Fledging Habitat Selection And Movements Of Juvenile Mallards In The Prairie Pothole Region, Cynthia E. Anchor

Electronic Theses and Dissertations

The Prairie Pothole Region (PPR) of North America provides critical habitat for waterfowl across life stages, but anthropogenic changes to the landscape have negatively impacted habitat quality for waterfowl. The mallard (Anas platyrhynchos) is abundant and socioeconomically valuable in the PPR, as it is a preferred target species of waterfowl hunters. Extensive research has evaluated breeding ecology of mallards in the PPR, but the period between juvenile mallards fledging and migrating has rarely been studied. The post-fledging ecology of juvenile mallards is a vital consideration for comprehensive waterfowl management. Further, juvenile mallards are a significant portion of hunter harvest at …

A Computational Fluid Dynamics Analysis Of The Temperature And Impurity Profiles In The Protodune-Sp Neutrino Detector, Jenna Harrison

Electronic Theses and Dissertations

Computational fluid dynamics (CFD) models of the ProtoDUNE single-phase detector were developed, refined, and analyzed. The ProtoDUNE single-phase detector is a prototype detector that is part of the Deep Underground Neutrino Experiment, an international research collaboration aimed at better understanding neutrinos and the role they play in our universe. The ProtoDUNE single-phase detector is used to gather data and inform design changes for the full-sized far detector prior to its construction. The effects of certain geometric features and heat sources on the thermal profiles within the liquid region of the detector were investigated in a set of parametric studies. The …

Machine-Learning And Meta-Analysis Techniques To Quantify And Predict Soil Organic Carbon, N2O-N And Co2-C Emissions In Cover Crop Systems, Deepak Raj Joshi

Electronic Theses and Dissertations

People worldwide are challenged by multiple threats including climate change, growing populations, and soil degradation. Addressing these challenges requires understanding of the local environment, farming systems and modern technologies. These technologies include new ways to process information that include artificial intelligence, machine learning and meta-analysis. Models produced using these technologies may be useful for predicting the consequences of implementing conservation practices that reduce GHG emissions as well as for determining the carbon footprint of cropping systems that include environmentally friendly conservation technologies such as growing cover crop. Therefore, our objectives of this study were to: 1) provide an overview of …

Understanding The Impact Of Human Germline Single-Nucleotide Variants, Samuel Adjei

Electronic Theses and Dissertations

All genetic variations in the human genome are due to mutations, and therefore determining the impact of the different categories of mutations, particularly nonsynonymous single nucleotide variants (SNVs) which are the most abundant in the population is essential for understanding the genetics of human diseases. Generations of mutation studies have focused on a relatively small number, partly due to technological limitations. However, advances in next-generation sequencing have allowed for empirical assessments of genome-wide mutations. genome sequence of any individual contains extensive protein-altering genetic variation (missense mutations) and of which only a few are unambiguously deleterious. Characterizing the phenotypes of these …

Identity Negotiations In Family Relationships: Discussing Substance Use Disorder Through The Communication Theory Of Identity, Sarah-Michele Q. Weaver

Electronic Theses and Dissertations

Guided by the communication theory of identity (CTI), the current study explores identity negotiations among family members who have experience with substance use disorder. Semi-structured interviews were conducted with 9 participants. Personalenacted, enacted-relational, and personal-relational identity gaps guide the scope and use of CTI. Findings mirrored 3 major themes in consideration of these identity gaps: (1) participants embraced or rejected SUD as a central aspect of personal identity, (2) participants experienced turbulence in relational identities due to SUD, and (3) personalrelational identity gaps and alignment surface in multiple contexts where interpersonal communication occurs.

Fire Emissions In The Tropical Indonesia: Improved Estimation And Driving Forces Investigation, Xiaoman Lu

Electronic Theses and Dissertations

Indonesia has experienced frequent fires since the 1970s due to large-scale peatland conversion and extensive drainage for agricultural development. Fire emissions released from these fires have led to Indonesia being the world’s 3rd largest emitter of greenhouse gases in certain years. Given that fire emissions severely affect climate, weather, and the human environment, numerous approaches have been developed to estimate fire emissions. However, existing emission estimates differ largely by a factor of four in this tropical country because of frequent cloud interferences and low-temperature smoldering fires. Therefore, this dissertation aims to improve the quantification of Indonesian fire emissions through enhanced …

Modeling The Flow And Creep Compliance Properties Of Ice-Cream Mixes, Hiran Ranaweera

Electronic Theses and Dissertations

This work documented the influence of the protein source (MPC80 and WPC80), protein content (4-12%), and temperature (5-35ºC) on the rheological behavior (flow curve, frequency sweep, and creep-recovery) of ice-cream mixes (ICM). For each protein source, the viscosity of the ICM was satisfactorily modeled (𝑅2>0.98, 𝑅2 𝑎𝑑𝑗>0.98, and E0.99), while the recovery phase was represented by an empirical model. The percentage of recovery (%R) of the ICM significantly decreased with the protein content.

Characterization Of Porcine Respiratory Epithelial Cells And Their Innate Immune Responses To Bacterial And Viral Ligands, Yam Prasad Gautam

Electronic Theses and Dissertations

In response to a pathogenic attack, the host produces a series of defense mechanisms through various intracellular signaling pathways. The byproduct of these signaling pathways helps tackle the invading pathogen and protects the body from getting into a diseased state. This system is called the immune system. The immune system can be divided into two branches namely the innate immune system and adaptive immune system. The groups of immune cells that provide protection regardless of the pathogen specificity constitute the innate immune system. The system that acts according to the pathogen specificity is called the adaptive immune response. The production …

A Post-Pneumonia Epizootic Evaluation Of The Rapid City, South Dakota Bighorn Sheep Herd, Amanda N. Ensrud

Electronic Theses and Dissertations

Pneumonia is a major factor affecting populations of free-ranging bighorn sheep (Ovis canadensis) across western North America. Pneumonia can occur in large-scale epizootics, during which greater than half of the population typically dies. After these epizootics, surviving ewes continue to conceive and bear lambs. However, lamb recruitment may remain low due to periodic or annual pneumonia outbreaks causing high lamb mortality rates, sometimes greater than 90%. Our study focused on the Rapid City, South Dakota bighorn sheep (BHS) herd that has recorded pneumonia-induced population decline since 2009. The first objective was to improve lamb health and survival by identifying and …

Emerging Respiratory Viral Pathogens, April Nelsen

Electronic Theses and Dissertations

Respiratory disease is arguably the most important health concern for the production animal industry [1-3]. Respiratory problems accounted for the highest mortality both in the swine and beef industries [1, 4]. Respiratory pathogens remain the most vital for swine and bovine research and disease monitoring [2, 5-7]. As pathogens, in particular viral pathogens, mutate, novel disease-causing viruses emerge, and there becomes an increasing concern and need for identification with control perimeters. One frequently identified disease syndrome is Porcine Respiratory Disease Complex (PRDC). PRDC is characterized by pneumonia of mixed respiratory infections with contributions from the environment and management practices. The …

Evaluating The Effects Of Medium Chain Fatty Acids On Sow Reproductive Characteristics, Offspring Biological Health Markers, And Growth Performance, Analicia J. Swanson

Electronic Theses and Dissertations

A sow’s diet can influence and her offspring not only in the suckling period, but well after weaning. The objective of this study was to determine how supplementing medium chain fatty acids (MCFA) in gestation and lactation impacted offspring growth performance as well as the biological markers of pig quality from the suckling period until week 6 of the nursery period. A total of 77 primparious and multiparious females and their 438 offspring were utilized in this study. Sows and gilts (218.15 kg ± 32.15 kg BW at d28 of gestation) were assigned to one of 2 dietary treatments: Control …

Effects Of Heterocycles On Biologically Relevant Molecules, Sajith Manjrake Vijayan

Electronic Theses and Dissertations

It is difficult to overstate the importance of heterocycles in many fields of science (including organic, inorganic, pharmaceutical, medicinal, and material science). Due to their remarkable potential for being involved in a vast array of reactions, heterocyclic molecules make up the majority of pharmaceuticals as well as more than half of all natural products. Moreover, nature widely uses heterocycles, and scientists learned to imitate nature by incorporating them into drug molecules to enhance their biological activity. In this research work emphasize the use of heterocycles in biomedical applications.

The first study presents the design, synthesis, and computational evaluation of four …

Inclusive Music Teacher Preparation In The Presbyterian College Of Education At Akropong-Akuapem, Ghana, Samuel Agbenyo

Electronic Theses and Dissertations

For the past three decades, Inclusive Education (IE) has emerged as a crucial educational agenda all over the world. In this study, IE is the practice of including students with disabilities in the general (music) education classroom, where they are educated together with their typically developing peers. Although IE efforts began in Ghana in 1957, some pitfalls have characterized the implementation process over the years, especially regarding music teacher preparation to implement the policies. Studies have reported a state of frustration among stakeholders, notably the elementary school teachers, who feel inadequately prepared to teach within IE settings. In this case …

Resilience Capacity Of School Meal Programs In Southeastern U.S. School Districts During The Covid-19 Pandemic: Findings From Mississippi, Louisiana, And West Virginia, Kritika Gupta

Electronic Theses and Dissertations

Mississippi (MS), Louisiana (LA), and West Virginia (WV) have some of the nation’s highest rates of poverty and health disparities, reflected in high rates of food insecurity. Many of the school districts in these states have greater than 40% of students qualifying for free meals and, under community eligibility, can provide meals free to all children. School meals play an important role in addressing food insecurity in the U.S. and those were severely affected by the COVID-19 pandemic. The ability of social systems (schools) to continue operations during adverse circumstances (pandemic) to ensure the sustained outcome of interest (food security) …

Hiv-1 Tat And Opioids: Implications For Stress-Related Psychopathology, Salahuddin Mohammed

Electronic Theses and Dissertations

The overarching goal of this dissertation was to assess the interaction of HIV-1 Tat protein with opioids like oxycodone and the hypothalamic-pituitary-adrenal (HPA) axis and develop novel therapeutic strategy to restore HPA dysfunction in adult HIV-1 Tat transgenic mice. In the past 3 decades, combined antiretroviral therapeutics (cART) has increased the life expectancy of HIV infected individuals, with a significant decline in the number of deaths. However, due the inability of cART to sufficiently target latent CNS viral reservoirs (predominantly microglia and astrocytes to a lesser extent), approximately 50% of the HIV+ infected population contends with neurological, neuropsychiatric and neuroendocrine …

Exploratory Studies On The Feasibility Of Developing Microneedles Using Hot Melt Extrusion Coupled With Fused Deposition Modeling 3-D Printing, Nikeeta Palande

Electronic Theses and Dissertations

Transdermal drug delivery enables efficient local and systematic drug delivery while offering advantages such as non-invasiveness, patient compliance, and avoidance of first pass metabolism compared to parenteral administration. Due to strong and the multi-layered structure of the skin creates complex barriers which makes the delivery of therapeutic agents across the skin becomes challenging. Microneedles have been shown to deliver drugs through the transdermal route by penetrating the skin’s protective barrier, stratum corneum (SC) and creating a pathway for drug permeation to the dermal tissue. Traditionally, microneedles were fabricated using various types of materials and process such as casting, injection moulding, …

Design Of An Ophthalmic Nanostructured Lipid Carrier Containing Amphotericin B And Nonadecanoic Acid For The Management Of Fungal Keratitis, Vishal Shah

Electronic Theses and Dissertations

Fungal keratitis is a fungal infection of the cornea. Untreated ocular infections can damage the unique, delicate structures of the eye leading to blindness and visual impairments. It primarily affects the corneal epithelium and stroma, although the endothelium and anterior chamber of the eye may get involved in more severe disease. Amphotericin B (AMB) is a macrocyclic polyene that poorly penetrates ocular tissues. However, AMB is a drug of choice used for the treatment of fungal keratitis caused by Candida. Nonadecanoic acid (NDA) is a 19-carbon fatty acid obtained from plants or bacteria which has shown antifungal activity and acts …

Covid-19 And Headache-Related Disability, Lauren Thaxter

Electronic Theses and Dissertations

Migraine is a common nervous system disorder that is a leading cause of disability worldwide, and approximately half of individuals with migraine report their migraine attacks cause substantial impairment in activities. A bidirectional relationship exists between migraine and psychological symptoms, and comorbid psychological symptoms compound migraine-related disability. Due to COVID-19 pandemic response procedures, many university students experienced institutional closures and corresponding increases in depression, stress, and anxiety, with the most prominent worries being about one's own health and the health of loved ones. The present study aimed to explore the relationship between COVID-19 status (pre-COVID vs. during COVID) and headache-related …

Design And Identification Of Organic Molecules As Agonists Of The Gabab Receptor And As Difluoro-C-Glycosylated Derivatives Of Flavonoids Using Molecular Modeling, Reem Alkhodier

Electronic Theses and Dissertations

The use of molecular modeling in pharmaceutical research is continuously growing. This growth is a result of the increasing number of experimental structures, the development of sophisticated modeling methods, and the improvement in computer performance by using GPUs and cloud computing. Nowadays, molecular modeling is routinely used in drug discovery to investigate biological processes and molecular properties. Herein, we use molecular modeling to investigate the behaviors of compounds with unique scaffolds.

Baclofen is the only marketed GABAB receptor agonist that is used for spasticity disorders, and it has shown promise as an anti-abuse agent. However, it has disadvantages that raise …

Synthesis And Charecterisation Of Methylene Blue Derivatives, Rohit Alluri

Electronic Theses and Dissertations

Since its discovery, the fluorescent dye known as methylene blue has been employed in a variety of scientific disciplines. Methylene blue (MB) for intraoperative fluorescence imaging has only lately been employed. 10-N-carbamoyl linkage modification of Methylene blue helps us in developing compounds with off-to-on fluorescence switch in the presence of near infrared (NIR). Due to its naturally induced photodamage to normal tissues and deeper penetration of lesion regions when compared to UV and visible light, near infrared (NIR) light is considered favorable among the broad radiation range. The previously synthesized derivatives are not completely soluble in water, they require other …

Development Of Hydroxyl Radical Protein Footprinting For Challenging Systems, Zhi Cheng

Electronic Theses and Dissertations

Structural biology plays an important role in modern molecular biosciences. High-resolution hydroxyl radical protein footprinting (HR-HRPF) is a mass spectrometry (MS) based method for analyzing protein topography at a spatial resolution from peptide up to the individual amino acids. Fast photochemical oxidation of protein (FPOP) is an HRPF technique that generates hydroxyl radicals by UV laser-induced photolysis of hydrogen peroxide. FPOP coupled with MS technology has successfully elucidated protein structure information, protein-protein interaction, and protein allosteric or conformational change. Even though FPOP coupled MS has quickly had a large impact on the field of biopharmaceutical analysis, serious limitations still remain. …

Physiological Corticosterone Attenautes Gp120-Mediated Microglial Activation And Is Associated With Reduced Anxiety-Like Behavior In Gp120-Expressing Mice, Emaya Marie Moss

Electronic Theses and Dissertations

Human immunodeficiency virus (HIV) persists as a global pandemic. Despite the benefits of combinatorial antiretroviral therapies (cART), virotoxic HIV proteins are still detectable within the central nervous system and approximately half of all cART-treated patients contend with neurological impairments. The mechanisms underlying these effects are not known, but likely involve actions of virotoxic HIV proteins including glycoprotein 120 (gp120). Glycoprotein 120 is neurotoxic, in part due to its capacity to activate microglia. Corticosterone, an endogenous anti-inflammatory, has been found to attenuate neuronal death caused by gp120-induced microglial cytokine production in vitro. But, the concentration-dependent effects of corticosterone to influence microglial …

Biopolymer Unfolding As A Process Of Biased Activated Barrier Crossing, Sudeep Adhikari

Electronic Theses and Dissertations

The biopolymer unfolding process can be conceptualized as the thermally activated crossing of a barrier in some energy landscape; the real-world unfolding dynamics are in correspondence with the rate of transit over the barrier. In this dissertation, we report on four projects that exploit this analogy to advance our understanding of so-called pulling experiments, in which a biopolymer chain is encouraged to unfold by direct application of forces to its two ends. Regardless of the specific experimental realization, standard pulling techniques give rise to a biased barrier crossing problem. The applied force has the effect of tilting the energy landscape. …

Student Success: Do First-Time, Full Time (Ftft) Students At The University Of Mississippi Enrolled In Intermediate Math (Ds 099) Earn Higher Grades In College Algebra (Math 121) Than Those Students Who Enrolled Directly In College Algebra?, Martina Brewer-Mister

Electronic Theses and Dissertations

Critics of developmental studies suggest that remedial courses may negatively influence a student’s program selection, persistence, and completion because remedial classes do not count toward graduation requirements (Long & Boatman, 2013). They have also found that over half of the students referred to remediation do not complete the courses (Clayton, Crosta, & Belfield, 2014; Bailey, Jeong, & Cho, 2010). The number is even lower for minority students (Bailey, 2010).

Using pre-existing data collected from the Office of Institutional Research, Effectiveness, and Planning at the University of Mississippi, an independent sample t-test and correlation analysis were conducted to examine the outcomes …

Spectroscopic Investigations Of Newly Developed Materials For Light Harvesting, Energy Conversion, And Bioimaging, Austin L. Dorris

Electronic Theses and Dissertations

A multitude of spectroscopic techniques were employed in the making of this dissertation to investigate materials with environmental, commercial, optoelectronic, bioimaging, and solar energy conversion applications. Graphene-like materials like biochar represent a field of study in which bioavailable materials are deployed for CO2 and heavy-metal adsorption to combat the detrimental effects of industry on the environment. Vibrational characterization of these materials via Raman spectroscopy is integral in elucidating the structure-function relationship and determining the best approach for material preparation and functionalization. Carbonaceous systems such as cellulose are also studied via Raman spectroscopy to interrogate the viability of cellulose nanocrystals as …

Core Size Conversion And Ligand Effects On Gold Nanomolecules Structure And Properties., Senthilkumar Eswaramoorthy

Electronic Theses and Dissertations

The size, shape and structure of the materials determines its properties in any scale. When the size of the material reaches nanometer scale, it shows a strikingly different property from the bulk. Monodisperse metal nanoparticles are highly desired due to its unique properties which can be explored for targeted applications. The nanoparticles with size less than 3 nm, atomically precise metal nanoparticles can be achieved, whereas nanoparticles in 3-100 nm range are monodisperse in size but not atomically monodisperse. Thiolate protected gold nanoparticles size less than 3 nm forms highly stable atomically precise compounds with distinct number of gold atoms …

First-Year Students' Perceptions Of Innate Intelligence, Ability, And Interest Across Four Stem Domains: A Comparative Structural Equation Model, Savannah Lea Kelly

Electronic Theses and Dissertations

Higher education institutions play a pivotal role in preparing students to acquire the skills necessary to enter the STEM workforce and serve as critical partners in the STEM educational-occupational pipeline. It is imperative that postsecondary institutions encourage equal opportunities for admittance into STEM domains. However, research has consistently demonstrated that gender and racial disparities continue to exist in STEM fields at the postsecondary level, particularly when viewed through the lens of disaggregated disciplinary data. One way to address inequitable attainment across STEM is to evaluate whether students prematurely preclude themselves from STEM participation due to a misalignment between students’ self-perceptions …

Faculty Perceptions Of Open And Affordable Education Resources, Megan Lowe

Electronic Theses and Dissertations

A now-common question regarding whether or not individuals should pursue college degrees is whether college is worth the cost. One of the ways that institutions of higher learning may help students reduce cost of attending college, thereby reducing the financial stresses, is to reduce expenses where possible. One place where institutions of higher learning can reduce expenses for students is course texts and materials. This reduction can be accomplished in several ways, but one way that has gained visibility is the use of open educational resources (OER) and affordable education resources (AER), also known as AOER. This qualitative research study …

Α-Tocopherol Succinate Nano Structured Lipid Carriers For The Ocular Delivery Of The Anticancer Agents And Statistical Modeling Of Release Study Profiles By Linear Mixed Models, Sushrut Marathe

Electronic Theses and Dissertations

Retinoblastoma (RB) is a rare type of cancer that develops quickly from immature retinal cells. Enucleation, external beam radiotherapy, episcleral plaque radiotherapy, and cryotherapy have been the treatment options for the RB.

Paclitaxel (PTX) is an effective antineoplastic medication with a wide range of applications in the treatment of malignant tumors., systemic toxicity, quick elimination, and resistance limit its clinical use. Due to its limited solubility, PTX formulations have proven difficult to develop, necessitating the use of Cremophor® EL and organic solvents. Furthermore, the blood-retinal barrier prevents PTX from penetrating into the ocular tissues. The goal of this work was …