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Identification And Characterization Of Three Novel Rumen Bacterial Species In Sheep Fed A Concentrate Diet, Reid Frederick Anema
Identification And Characterization Of Three Novel Rumen Bacterial Species In Sheep Fed A Concentrate Diet, Reid Frederick Anema
Electronic Theses and Dissertations
Sheep production in the United States is a popular venture for both small farmers and large enterprise owners, as there is a market for end products such as wool and meat. One major factor of raising sheep is nutrition as an adequate diet will allow an animal to reach its full genetic potential for growth. With that in mind, the composition of the diet must be formulated to benefit the animal. Ruminants have the ability to use a variety of plants that are often inedible for humans to create products that humans can consume. These varying feedstuffs, whether they include …
Anemia In Highly Prolific Sows: Implications On Piglet Outcomes, Farrowing Complications, And Longevity Considerations, Katlyn A. Mcclellan
Anemia In Highly Prolific Sows: Implications On Piglet Outcomes, Farrowing Complications, And Longevity Considerations, Katlyn A. Mcclellan
Electronic Theses and Dissertations
No abstract provided.
Development And Characterization Of Transparent Soil Using Biodegradable Polysaccharides, Said Badshah
Development And Characterization Of Transparent Soil Using Biodegradable Polysaccharides, Said Badshah
Electronic Theses and Dissertations
No abstract provided.
Ecophysiology Of Bradyrhizobium Diazoefficiens Usda 110, Armaan Kaur Sandhu
Ecophysiology Of Bradyrhizobium Diazoefficiens Usda 110, Armaan Kaur Sandhu
Electronic Theses and Dissertations
With increasing demand for soybean, maximizing plant yield is important yiel is dependent on nitrogen availability, but nitrogen fertilizers can meet the plant's needs but have severe environmental impacts. An economically and environmentally sustainable approach is to enhance nitrogen availability through Biological Nitrogen Fixation by symbiotic rhizobia, Bradyrhizobium, an efficient nitrogen fixer for soybean. This symbiosis begins with attachment of rhizobia to legume roots. Root and rhizobia surface properties play a significant role in this attachment. Another major factor affecting root colonization is bacterial competition ability. There is a lack of knowledge on the role of bacterial surface properties, competition …
An Investigation Of Bidder Behaviour In Wic Infant Formula Rebate Auctions, Ashma Pandey
An Investigation Of Bidder Behaviour In Wic Infant Formula Rebate Auctions, Ashma Pandey
Electronic Theses and Dissertations
This research investigated the competitive bidding dynamics for infant formula rebate contracts within the Special Supplemental Nutrition Assistance Program for Women, Infants, and Children (WIC). I begin by focusing on the differences between winning and losing bids. The study employs multiple regression to predict rebate bids submitted by major manufacturers when they win a contract. I next conduct a paired t-test for each manufacturer – revealing statistically significant differences between predicted bids (based on the parameters from the winning model) and actual bids when a manufacturer did not win. This suggests that each manufacturer bids significantly lower rebates (higher net …
Regulatory Landscapes: Transcriptome And Microrna Regulated Senescence And Dormancy In Grapevines And Gene Regulatory Networks In Nitrogen-Fixing Soybean Nodules, Ramandeep Kaur
Electronic Theses and Dissertations
Grapevine and soybean are two economically important crops, each with unique yet equally crucial physiological processes that profoundly influence their growth and productivity. Grapevine (Vitis sp.), a temperate fruit crop, employs dormancy to withstand winter challenges and can grow in various regions worldwide. Understanding the molecular mechanisms involved in dormancy in Vitis species, is crucial for improving grapevine selection for resilience in northern temperate regions. Dormancy induction is modulated by decreasing photoperiods in some Vitis species, enhancing their ability to prepare for winter stress conditions. Understanding the molecular underpinnings of response to photoperiod will provide potential markers for selecting genotypes …
The Normative Requirement For Shared Decision Making (Sdm) In Healthcare Ethics, Margaret Nornor-Quadjie
The Normative Requirement For Shared Decision Making (Sdm) In Healthcare Ethics, Margaret Nornor-Quadjie
Electronic Theses and Dissertations
Medicine and medical technology started to advance after World War II. During that period, the practice of medicine became technical. A lot began to happen in the biomedical world during the period after WWII that attracted comments, criticisms, and analyses from scholars. Perhaps, the 1947 Doctors’ Trial at the Nuremberg Tribunal and the Nuremberg Code may be said to be the defining moment for bioethics. These events eventually led to, in the United States, the passage of the National Research Act of 1974 that established the Institutional Review Board system and the National Commission for Protection of Human Subjects of …
Ethanol Dysregulates Sirt1-Mediated Lipogenic Signaling Pathways Through Α4*-Nicotinic Acetylcholine Receptors In Hepatocytes., Caitlin Christina Wilkerson
Ethanol Dysregulates Sirt1-Mediated Lipogenic Signaling Pathways Through Α4*-Nicotinic Acetylcholine Receptors In Hepatocytes., Caitlin Christina Wilkerson
Electronic Theses and Dissertations
Alcohol-associated liver disease (ALD) is a broad spectrum of diseases ranging from steatosis to severe hepatic cirrhosis, none of which have any FDA approved therapies. Downregulation of hepatic Sirtuin 1 (Sirt1) activity by ethanol has been shown to lead to an upregulation of the pro-lipogenic gene targets under its jurisdiction, resulting in increased lipogenesis and triglyceride accumulation. It was hypothesized that ethanol acts on α4*-nicotinic acetylcholine receptors (α4*-nAChRs) in hepatocytes to decrease Sirt1 expression, which ultimately dysregulates lipid metabolic homeostasis. Ethanol’s effects were investigated in cultured AML12 hepatocytes and in WT primary mouse hepatocytes acutely exposed to ethanol. Consistent with …
The Interplay Between Lung Adenocarcinoma, Nutrient Availability, And The Microbiome., Alexis A. Vega
The Interplay Between Lung Adenocarcinoma, Nutrient Availability, And The Microbiome., Alexis A. Vega
Electronic Theses and Dissertations
Lung cancer is one of the most common forms of cancer diagnosed, and has the highest lethality rate across all other forms of cancer in the U.S. While current therapeutic options include chemo-, immuno-, and radio-therapy, the benefits of caloric or nutrient restriction on cancer cells has also been investigated. Due to the many biological functions associated with methionine, many have proposed a methionine restricted diet would lead to favorable outcomes when combating cancer. Although our cells are incapable of synthesizing methionine, the bacteria found in our microbiome can. Furthermore, recent discoveries suggest an independent microbiome found within tumors that …
Genetic Risk Scores For Hypertension And Chronic Kidney Disease In African Americans., Aastha Kakar
Genetic Risk Scores For Hypertension And Chronic Kidney Disease In African Americans., Aastha Kakar
Electronic Theses and Dissertations
Hypertension (HT) and chronic kidney diseases (CKD) are complex conditions, disproportionally prevalent among African Americans (AA) and are influenced by multiple genetic as well as environmental factors. Genetic risk scores (GRS) enable the analysis of the combined effects of multiple single nucleotide polymorphisms (SNPs). This study investigates the association of blood pressure (BP) and CKD GRS with BP, hypertension (HT) and CKD; early-onset HT and CKD; and investigates interactions of the GRSs with environmental measures in AA. We observed a significant association between the BP-GRS with HT, SBP and DBP. The odds of HT for one standard deviation (s.d.) increase …
Investigating The Effects Of Subchronic Dietary Zinc Supplementation On Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease., Oluwanifemi Esther Bolatimi
Investigating The Effects Of Subchronic Dietary Zinc Supplementation On Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease., Oluwanifemi Esther Bolatimi
Electronic Theses and Dissertations
Zinc deficiency is associated with metabolic dysfunction-associated steatotic liver disease (MASLD). Previous studies show zinc supplementation improves steatosis, but its therapeutic effects in established MASLD remain unclear. We developed a model to characterize the effects of zinc supplementation on high-fat diet (HFD) induced MASLD and hypothesized established MASLD would be attenuated. Mice were fed control diet or HFD for 12 weeks and then grouped into normal or zinc-supplemented diets for 8 additional weeks. At euthanasia, plasma and liver tissues were collected for phenotypic analysis. Twelve weeks of HFD altered glucose clearance and body composition. Eight weeks of subsequent zinc supplementation …
The Impact Of Environmental Pollutants On Alcohol-Associated Liver Disease Pathogenesis., Tyler Charles Gripshover
The Impact Of Environmental Pollutants On Alcohol-Associated Liver Disease Pathogenesis., Tyler Charles Gripshover
Electronic Theses and Dissertations
Steatotic liver disease is brought upon by differing etiologies and its global prevalence is expected to keep increasing over the next several decades. Particularly, alcohol-associated liver disease (ALD) manifests from excessive alcohol consumption where the liver retains lipids and progresses with metabolic dysfunction. Previous studies have demonstrated that environmental pollutants, polychlorinated biphenyls (PCBs) promote metabolic dysfunction associated steatotic liver disease (MASLD), in diet-induced obesity models. However, it is unknown if environmental pollutants may also promote ALD pathogenesis. Thus, this dissertation focuses on characterizing the effects of PCB126 in a rodent ALD model followed by multiple ‘Omics approaches to identify mechanisms …
Environmental Exposures And Male Reproductive Outcomes., Damilola Rukayat Owoade
Environmental Exposures And Male Reproductive Outcomes., Damilola Rukayat Owoade
Electronic Theses and Dissertations
Male sexual dysfunction comprises various conditions, including erectile dysfunction (ED) and ejaculatory dysfunction. Testosterone deficiency (TD), which has been linked to some of these sexual dysfunctions, is characterized by low production of testosterone by the testes. These male reproductive outcomes may develop due to exposure to various risk factors, including environmental exposures. These environmental exposures may include volatile organic compounds (VOCs) and tear gas. This dissertation aims to examine the effects of tear gas exposure and VOCs on male reproductive outcomes. The association between tear gas exposure and male reproductive outcomes was assessed using data obtained from an online anonymous …
Exploring Burnout And Work Engagement In The United States Refugee Resettlement Policy-Practice Domain: A Qualitatively Driven Mixed-Method Study., Eva X. Nyerges
Electronic Theses and Dissertations
Refugee resettlement workers are crucial actors within refugee resettlement, supporting newcomers’ acculturation into a new society. Little is known about the comprehensive range of organizational characteristics that impact workers’ experiences of burnout and work engagement. This qualitatively driven mixed-method study using Constructivist Grounded Theory analytic techniques aimed to develop a holistic understanding of the organizational elements influencing burnout and work engagement among refugee resettlement workers. Further, the study aimed to illuminate the mechanisms by which job demands and resources influence burnout and work engagement. In-depth qualitative interviews with 22 refugee resettlement workers operating in a southeastern state of the United …
Investigation Of Heterocyclic Amines And N-Acetyltransferase 2 Genetic Polymorphism In The Dysregulation Of Hepatic Energy Homeostasis: A Gene-Environment Approach., Kennedy M Walls
Electronic Theses and Dissertations
Heterocyclic amines (HCAs) are mutagens generated when cooking meat for prolonged periods of time or until well-done. Recent epidemiological studies reported significant associations between dietary HCA exposure and insulin resistance and type II diabetes. However, no previous studies have examined if HCAs, independent of meat consumption, contributes to pathogenesis of insulin resistance or metabolic disease. It is well known that HCAs require hepatic bioactivation by cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 2 (NAT2). NAT2 expresses a well-defined genetic polymorphism in humans that, depending on the combination of NAT2 alleles, correlate to rapid, intermediate, or slow acetylator phenotypes that exhibit differential …
Bayesian Strategies For Propensity Score Estimation In Causal Inference., Uthpala I. Wanigasekara
Bayesian Strategies For Propensity Score Estimation In Causal Inference., Uthpala I. Wanigasekara
Electronic Theses and Dissertations
Causal inference is a method used in various fields to draw causal conclusions based on data. It involves using assumptions, study designs, and estimation strategies to minimize the impact of confounding variables. Propensity scores are used to estimate outcome effects, through matching methods, stratification, weighting methods, and the Covariate Balancing Propensity Score method. However, they can be sensitive to estimation techniques and can lead to unstable findings. Researchers have proposed integrating weighing with regression adjustment in parametric models to improve causal inference validity. The first project focuses on Bayesian joint and two-stage methods for propensity score analysis. Propensity score modeling …
Causal Inference For The Effect Of Continuous Treatment On Time-To-Event Outcomes And Mediation Analysis On Health Disparities In Observational Studies., Triparna Poddar
Causal Inference For The Effect Of Continuous Treatment On Time-To-Event Outcomes And Mediation Analysis On Health Disparities In Observational Studies., Triparna Poddar
Electronic Theses and Dissertations
The dissertation comprises two projects related to causal inference based on observational data. In healthcare research, where abundant observational data such as claims data and electronic records are available, researchers often aim to study the treatment effect and the pathway of that effect. However, estimating treatment effects in observational data presents challenges due to confounding factors. The first project focuses on estimating continuous treatment effects for survival outcomes, while the second concentrates on mediation analysis, allowing the exploration of the pathway of the causal effect. Both projects involve addressing confounding variables. In the first project, I investigate estimation of the …
Intestinal Microbiome, Fecal Fermentation Profile, And Health Indices In Hiv Infected Men Versus Non-Infected Controls, Mary Andreae, Mary C. Andreae Mrs
Intestinal Microbiome, Fecal Fermentation Profile, And Health Indices In Hiv Infected Men Versus Non-Infected Controls, Mary Andreae, Mary C. Andreae Mrs
Electronic Theses and Dissertations
Many HIV-positive (HIV+) males on Highly Active Anti-Retroviral Therapy (HAART) experience metabolic abnormalities, including Non-Alcoholic Fatty Liver Disease (NAFLD) and lipodystrophy. The intestinal microbiota and short chain fatty acids (SCFA), participate in bidirectional communication with their host. Dysbiosis in HIV+ males on HAART demonstrate a Prevotella-rich enterotype shaped by multiple factors including, medications, adiposity, diet, intestinal permeability, and lifestyle; our objective was to investigate these factors. 19 HIV+ and 21 HIV- males were enrolled. BMI and hip-to-waist ratio (H:W) were obtained, and FibroScan for liver health. Intestinal permeability markers Claudin-21, flagellin, and intestinal fatty acid binding protein (IFABP) in …
Covid-19 Vaccine Uptake In The Hispanic And Latinx Communities Of Northeast Tennessee, Gabriela Abrego
Covid-19 Vaccine Uptake In The Hispanic And Latinx Communities Of Northeast Tennessee, Gabriela Abrego
Electronic Theses and Dissertations
This work addresses the underlying issues surrounding COVID-19 vaccine uptake in Hispanic and Latinx communities in the Northeast region of Tennessee. A qualitative, phenomenological research approach was used to conduct interviews and data from the interviews was used to inform a survey instrument. The interview guide in the qualitative phase of the study was based on the Health Belief Model (HBM) developed by Rosenstock (Rosenstock, 1974). A quantitative approach was then used by piloting the survey instrument in the study population. Common themes found through the interviews were: previous negative experience with COVID-19 vaccination, previous negative experience as a result …
Flavonol Glucosylation: A Structural Investigation Of The Flavonol Specific 3-O Glucosyltransferase Cp3gt, Aaron S. Birchfield
Flavonol Glucosylation: A Structural Investigation Of The Flavonol Specific 3-O Glucosyltransferase Cp3gt, Aaron S. Birchfield
Electronic Theses and Dissertations
Flavonoid glycosyltransferases (GTs), enzymes integral to plant ecological responses and human pharmacology, necessitate rigorous structural elucidation to decipher their mechanistic function and substrate specificity, particularly given their role in the biotransformation of diverse pharmacological agents and natural products. This investigation delved into a comprehensive exploration of the flavonol 3-O GT from Citrus paradisi (Cp3GT), scrutinizing the impact of a c-terminal c-myc/6x histidine tag on its enzymatic activity and substrate specificity, and successfully achieving its purification to apparent homogeneity. This established a strong foundation for potential future crystallographic and other structure/function analyses. Through the strategic implementation of site-directed mutagenesis, a thrombin …
The Experiences Of Students During Covid-19 School Disruptions, Brandi Bullock
The Experiences Of Students During Covid-19 School Disruptions, Brandi Bullock
Electronic Theses and Dissertations
The purpose of this study was to identify the perceptions of educators with respect to student experiences between March 2020 and February 2021 related to academics, social-emotional health, and safety and security. Data collection strategies included one-on-one interviews with 12 educators in one East Tennessee school district. To qualify for the study, participants had to have taught during COVID-19 schooling disruptions and have taught either 1st, 2nd, 3rd, 4th, or 5th grade in the 2022-23 school year. Data analysis was based on Systems Theory (Laszlo & Krippner, 1998) and Change Theory (Fullan, 2020). The results revealed 5 key themes that …
Elucidation Of The Role Of Avocado Wri1 And Wri2 And Their Ability To Affect Oil Content And Composition When Co-Expressed With Pdat1 And Dgat1, Jyoti Ranjan Behera
Elucidation Of The Role Of Avocado Wri1 And Wri2 And Their Ability To Affect Oil Content And Composition When Co-Expressed With Pdat1 And Dgat1, Jyoti Ranjan Behera
Electronic Theses and Dissertations
Plants synthesize and store oil, mostly as triacylglycerols (TAG), in seeds that is transcriptionally controlled by WRINKLED1 (WRI1), an APETALA2 (AP2) transcription factor. Among the four Arabidopsis WRI paralogs, WRI2 is nonfunctional, while the others are expressed in a tissue-specific manner. Additionally, two rate-limiting enzymes, diacylglycerol acyltransferase (DGAT) and phospholipid diacylglycerol acyltransferase (PDAT) catalyze the terminal step in TAG assembly and contribute to oil accumulation. Avocado (Persea americana) mesocarp, a non-seed tissue, accumulates significant amounts of TAG (~70% by dry weight) enriched with heart-healthy oleic acid. The oil accumulation stages in mesocarp coincide with the high expression of …
Investigating The Role Of Maternal Adiposity On Human Breast Milk And Preterm Infant Stool Short Chain Fatty Acid And Microbiome Profiles, Kristy L. Thomas
Investigating The Role Of Maternal Adiposity On Human Breast Milk And Preterm Infant Stool Short Chain Fatty Acid And Microbiome Profiles, Kristy L. Thomas
Electronic Theses and Dissertations
Preterm birth is the number one cause of death in neonates, accounting for 35% of neonatal mortality. The preterm birth rate in the U.S. in 2021 was 10.5%, disproportionally affected by race and ethnicity. Obese women have an increased risk of preterm pregnancy, and if delivered before 37 weeks of gestation, the offspring have higher rates of complications that extend from the neonatal period into life-long metabolic and immune adverse outcomes. In the early months after delivery, preterm infants have higher rates of adverse health outcomes than term infants, including infections, extrauterine growth restrictions, respiratory, metabolic, and neurological complications, necrotizing …
E-Cigarettes: What Is The Relationship Between E-Cigarette Usage And Periodontal Disease?, Deborah Rose
E-Cigarettes: What Is The Relationship Between E-Cigarette Usage And Periodontal Disease?, Deborah Rose
Electronic Theses and Dissertations
The dental community has a broad understanding of how traditional combustible cigarettes affect the oral cavity of the dental patient but there is little research available on the effects that e-cigarettes have on the patient’s dental health. Vaping products have been marketed as a healthier option over traditional combustible cigarettes. Since they were first introduced in 2003, very little research has been performed to understand their dental implications. This project was executed to investigate the chemicals associated with these vaping products and how they possibly contribute to the progression of periodontal disease. This research project was conducted with the contribution …
Competencies Texas A&M Agrilife Extension Agents Need To Manage Conflict In Master Gardener Programs, Jayla Brook Fry
Competencies Texas A&M Agrilife Extension Agents Need To Manage Conflict In Master Gardener Programs, Jayla Brook Fry
Electronic Theses and Dissertations
Texas A&M AgriLife Extension agents manage volunteer programs with vast efforts in public education. Volunteer programs such as the Texas Master Gardener program are significant to the public because they provide a service by educating people in horticulture and related topics. Extension agents oversee volunteer programs such as the Master Gardener program. The Texas Master Gardener program is comprised of more than 9,000 volunteers who give over 500,000 hours of service to their communities. When there are misaligned goals or personality conflicts, it may impact the program’s mission and educational efforts. Extension agents must manage those situations to retain the …
Project: Mhealth Applications For Educating Community Nurses, Nkemdilim Stacy Egbo
Project: Mhealth Applications For Educating Community Nurses, Nkemdilim Stacy Egbo
Electronic Theses and Dissertations
Hypertension is a chronic health condition linked to high morbidity and mortality rates in America and around the world. Hypertension care in developing and underdeveloped countries requires quick intervention. The proliferation of smart technologies and mobile health applications offer some leverage for the alternative management of hypertension, but evidence related to effectiveness in Nigeria are limited. The purpose of the study was to assess the impact of m-Health apps on hypertension self-management through nurses’ education in Southern region of Nigeria, as well as their self-confidence or efficacy using the Hypertension Evaluation of Lifestyle Management assessment. A quasi-experimental pretest-posttest design was …
Evaluation Of Cardiovascular Risk Compliance For Primary Prevention: A Quality Improvement Project, Rachelle S. Campbell
Evaluation Of Cardiovascular Risk Compliance For Primary Prevention: A Quality Improvement Project, Rachelle S. Campbell
Electronic Theses and Dissertations
The American College of Cardiology and American Heart Association clinical practice guidelines recommend a cardiovascular risk assessment every 4–6 years in ages 40–75 to prevent cardiovascular disease. This DNP project aimed to improve awareness, compliance with cardiac risk assessments, and stratification of high and low-risk patients. This quality improvement project utilized the Johns Hopkins nursing evidence-based model to create the inquiry question and foundational plan for implementing the clinical practice guideline, calculating the cardiac risk score, and creating a clinical workflow process. A retrospective chart audit was guided by the Plan-Do-Study-Act (PDSA) method to collect pre- and postintervention data on …
Assessment Of Self-Efficacy And Practice Change Following Pressure Injury Education In A Long-Term Care Facility, Charity L. Booker
Assessment Of Self-Efficacy And Practice Change Following Pressure Injury Education In A Long-Term Care Facility, Charity L. Booker
Electronic Theses and Dissertations
The purpose of this scholarly project was to evaluate if pressure injury education improved nursing knowledge and self-efficacy in the prevention and management of pressure injuries with the intent to improve practice. A literature review was conducted to evaluate educational interventions for adult learners and nursing roles in the care process. Existing studies indicated that patient outcomes are improved when nurses have adequate knowledge in pressure injury prevention. This quality improvement project was implemented in a long-term care facility with 28 nursing staff. The Agency for Healthcare Research and Quality pressure injury best practices presentation was the basis for the …
Digital Twins Of The Living Knee: From Measurements To Model, Thor Erik Andreassen
Digital Twins Of The Living Knee: From Measurements To Model, Thor Erik Andreassen
Electronic Theses and Dissertations
Modern medicine has dramatically improved the lives of many. In orthopaedics, robotic surgery has given clinicians superior accuracy when performing interventions over conventional methods. Nevertheless, while these and many other methods are available to ensure treatments are performed successfully, far fewer methods exist to predict the proper treatment option for a given person. Clinicians are forced to categorize individuals, choosing the best treatment on “average.” However, many individuals differ significantly from the “average” person, for which many of these treatments are designed. Going forward, a method of testing, evaluating, and predicting different treatment options' short- and long-term effects on an …
Is Conventional Colonoscopy More Effective Than Computed Tomography Colonography In The Screening Of Colorectal Cancer Among Young African American Adults?, Abena Abrafi Nimako
Is Conventional Colonoscopy More Effective Than Computed Tomography Colonography In The Screening Of Colorectal Cancer Among Young African American Adults?, Abena Abrafi Nimako
Electronic Theses and Dissertations
Healthcare journalist Brenda Goodman’s article on CNN Health on October 10, 2022, about a new study examining the effectiveness of colonoscopies, essentially concluded that the efficacy of conventional colonoscopy is in question. This research sought to establish whether conventional colonoscopy is more effective than computed tomography (CT) colonography in screening colorectal cancer among young African American adults. The researcher employed a literature review and a case-control research design to gather data on the subject. Data were collected from literature, the SEER database, the CDC, and the American Cancer Society websites. The study sample consisted of African Americans between the ages …