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Articles 5101 - 5130 of 15385
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Community-Based Coastal Restoration: Long Term Impacts On Habitats And People In Volusia County, Rachel Wimmer
Community-Based Coastal Restoration: Long Term Impacts On Habitats And People In Volusia County, Rachel Wimmer
Electronic Theses and Dissertations
Coastal habitats provide invaluable economic and ecosystem services. However, coastlines are eroding at increasing rates due to anthropogenic and climate driven changes. Grey and green infrastructure solutions have been proposed to retard the decay of coastlines, with oysters serving as a popular living shoreline. Three community-based stabilizations that implemented living shorelines and engaged local communities in restoration efforts over the past decade in Volusia County were revisited to determine if they were successful and if they produced positive public perceptions of success. Chicken Island, which was restored after waves, boat wakes, tides, and adverse weather altered the natural shoreline, had …
Evaluation Of Postoperative Air Leak And Chest Tube Drainage Systems After Pulmonary Resection, Kristina Jacobsen
Evaluation Of Postoperative Air Leak And Chest Tube Drainage Systems After Pulmonary Resection, Kristina Jacobsen
Electronic Theses and Dissertations
Postoperative air leaks are the most common complication after a pulmonary resection. There is no data in the literature comparing the traditional and digital chest drainage system after a robotic-assisted pulmonary lobectomy. In 182 eligible patients, this retrospective study evaluated the association between digital and traditional drainage systems with postoperative chest tube days, hospital length of stay, chest tube reinsertion during hospitalization, and 30-day readmission for pneumothorax following a robotic-assisted lobectomy. The groups did not differ significantly in terms of age, gender, BMI, smoking, adhesions or neoadjuvant therapy. Patients with the digital drainage system had a mean chest tube duration …
Reconceptualizing Responsiveness For Network Governance: Insights From Cross-Sector Efforts To Assist The Displaced Population From Puerto Rico In Central Florida, Safiya Prysmakova
Reconceptualizing Responsiveness For Network Governance: Insights From Cross-Sector Efforts To Assist The Displaced Population From Puerto Rico In Central Florida, Safiya Prysmakova
Electronic Theses and Dissertations
This study further expands current knowledge on responsiveness in the public administration field and examines factors that contribute to more responsive public service delivery networks. This research reconceptualized the concept of responsiveness under the lens of New Public Governance as a legitimate democratic public value and answered the following research questions: What constructs constitute to the concept of public service responsiveness? How can public service responsiveness be measured at the network level? Does the complexity of public service provision affect perceived public service network responsiveness? How do collaborative processes across network partners, community support, and resource munificence affect the responsiveness …
Telephone-Delivered Cognitive Behavioral Therapy For Insomnia In Patients With Cancer: A Randomized Controlled Trial, Andel Nicasio
Telephone-Delivered Cognitive Behavioral Therapy For Insomnia In Patients With Cancer: A Randomized Controlled Trial, Andel Nicasio
Electronic Theses and Dissertations
This study examined the efficacy and feasibility of a brief telephone-delivered CBT-I (TeleCBT-I) intervention in cancer patients compared to a control group. The study used a randomized controlled trial design. The TeleCBT-I program consisted of a brief four-week CBT-I program adapted for cancer patients. Patients completed assessment measures at pre-treatment, post-treatment and one-month follow-up. Out of 184 patients screened, 39 were randomly assigned, and 35 (TeleCBT-I, n = 19; Control, n = 16) completed pre- and post-treatment measures and were included in the analyses. Compared to control group, the TeleCBT-I group reported decreased insomnia severity symptoms (p < .014), improved sleep quality (p < .023), and reduced dysfunctional beliefs about sleep (p = .039) at post-treatment with sustained treatment effects at one-month follow-up. Sleep measures yielded large effect sizes (Hedges' g, 0.84-2.7). Although the TeleCBT-I group indicated improvements in fatigue, general functioning, physical well-being, functional well-being, and physical quality of life, effects at follow-up were observed only for fatigue, functional well-being and physical quality of life. No effects were found on depression at any of the time points. In terms of feasibility, TeleCBT-I demonstrated high adherence, high homework completion and high overall satisfaction. These results advance the empirical evidence of CBT-I in cancer patients and support the use of telephone-delivered CBT-I to widely disseminate and implement among patients with cancer.
Unraveling The Role Of Phenylethanolamine N-Methyltransferase (Pnmt+) Cells In-Vivo, Sanjana Manja
Unraveling The Role Of Phenylethanolamine N-Methyltransferase (Pnmt+) Cells In-Vivo, Sanjana Manja
Electronic Theses and Dissertations
Phenylethanolamine N-methyltransferase (Pnmt) is the enzyme that N-methylates norepinephrine to produce the stress hormone/neurotransmitter, epinephrine, which is abundantly expressed in adrenal glands. Developmental studies have also identified Pnmt expression in the embryonic heart and several areas of the brain, including brainstem, cerebellum, and hypothalamus. Thus, we hypothesize that selective ablation of Pnmt+ cells will have detrimental effects on cardiovascular, neuromuscular, and metabolic processes. To uncover the importance of Pnmt+ cells in vivo, we generated a novel Diphtheria Toxin A (DTA) suicide model (Pnmt+/Cre; R26+/DTA) to selectively ablate Pnmt-expressing (Pnmt+) cells in mice. Appearing normal at birth, Pnmt-Cre/DTA mice began to …
An Investigation Of College Student-Athletes' Mental Health Stigma, Help-Seeking Attitudes, Depression, Anxiety, And Life Stress Scores Using Structural Equation Modeling, Saundra Tabet
Electronic Theses and Dissertations
The purpose of this study was to investigate the directional relationship between student-athletes' degree of mental health stigma, help-seeking attitudes, depression, anxiety, and life stress scores. This investigation tested the theoretical model that student-athletes' (N = 621) degree of mental health stigma (as measured by the Perceived Devaluation-Discrimination Scale – Adapted [PDD-A; Eisenberg et al., 2009]) contributed to their attitudes towards help-seeking (as measured by the Attitudes Toward Seeking Professional Psychological Help – Short Form [ATSPPH-SF; Fisher & Farina, 1995]) and levels of depression (as measured by the Patient Health Questionnaire – 9 [PHQ-9; Kroenke et al., 2001]), anxiety (as …
Development Of Filial Obligation In Young Adults: An Examination Of Crisis And Lifespan Theory, Rachel Bassett
Development Of Filial Obligation In Young Adults: An Examination Of Crisis And Lifespan Theory, Rachel Bassett
Electronic Theses and Dissertations
Formal care institutions are unable to meet care demands. As a result, informal caregivers (friends, family, neighbors) are called upon to fulfill this need. Adult children make up the majority of these informal caregivers. Adult children vary with respect to whether or not they provide care, and the amount of care provided. Filial obligation and attachment are positive predictors of these care behaviors. A better understanding of how these factors emerge and invoke caregiving behaviors is crucial. The primary hypothesis of this study was that anxiety attachment dimension score would positively relate to baseline filial obligation, and that avoid attachment …
A Comparison Of Sixth-Grade English Language Arts And Mathematics Achievement Between Middle Schools And K-8 Schools, Brennan Asplen
A Comparison Of Sixth-Grade English Language Arts And Mathematics Achievement Between Middle Schools And K-8 Schools, Brennan Asplen
Electronic Theses and Dissertations
The purpose of this study was to compare the academic achievement of sixth grade students enrolled in a traditional middle school model versus those enrolled in a K-8 school model by analyzing English Language Arts (ELA) and mathematics scores. Developmental Scale Score (DSS) data from the 2017 Florida Standards Assessment (FSA) were collected from three K-8 schools and three middle schools in one high-performing Florida school district. Results from an independent samples t-test revealed that middle school student scores were slightly higher in overall ELA and mathematics proficiency, but the differences were not substantive. Cross-tabulation was utilized to compute the …
Ab Toxins: Recovery From Intoxication And Relative Potencies, Patrick Cherubin
Ab Toxins: Recovery From Intoxication And Relative Potencies, Patrick Cherubin
Electronic Theses and Dissertations
AB-type protein toxins have a catalytic A subunit attached to a cell-binding B subunit. Ricin, Shiga toxin (Stx), exotoxin A, and diphtheria toxin are AB toxins that act within the host cytosol and kill the host cell through pathways involving the inhibition of protein synthesis. Our overall goal is to help elucidate the cellular basis of intoxication for therapeutic development. According to the current model of intoxication, the effect of AB toxins is irreversible. To test this model, we developed a system that uses flow cytometry and a fluorescent reporter to examine the cellular potency of toxins that inhibit protein …
Bridging The Gap Between Hospital And School: Addressing The Academic And Social-Emotional Needs Of Students With Chronic Illness, Nicole Eggert
Bridging The Gap Between Hospital And School: Addressing The Academic And Social-Emotional Needs Of Students With Chronic Illness, Nicole Eggert
Electronic Theses and Dissertations
This dissertation in practice examined the literature and a sample of existing programs that addressed the educational and social-emotional challenges of students with chronic illness in order to bridge the gap between hospital discharge and school re-entry. Literature showed that the hospital homebound setting was problematic for chronically ill students due to minimal hours of academic instruction and little interaction with peers. Students with chronic illness were at higher risk for maladaptive behaviors, lower educational attainment, and higher use of social services. Programs created at other facilities to address this problem were visited and reviewed for pertinent information such as …
Teacher Candidates' Civic Attitudes And Civic Knowledge: A Comparative Study, Brian Furgione
Teacher Candidates' Civic Attitudes And Civic Knowledge: A Comparative Study, Brian Furgione
Electronic Theses and Dissertations
The foundations of a democratic society are the citizens who engage in its political processes and functions. The democratic skills and dispositions needed to be engaged citizens must be embedded within the school system of that society. In the United States, teachers serve as the delivery system of these skills and dispositions, and it is therefore imperative to understand who these teachers are as citizens. Leveraging survey research and various quantitative measures, the civic attitudes and civic knowledge of teacher candidates in various fields were investigated. Using self-reported demographic information, teacher candidates were compared based on their academic program track, …
Bone Morphogenetic Protein 7 Inhibits Pyroptotic Cell Death In Vascular Smooth Muscle Cells Of Atherosclerotic Apolipoprotein E -/- Mice, Kaley Garner
Electronic Theses and Dissertations
Atherosclerosis (ATH) is an inflammation-mediated disease in which cell death underlies the formation of lesions along the intima layer of vascular walls resulting in vessel narrowing, decreased blood flow, and increased risk of lesion rupture leading to myocardial infarction and stroke. The current study was undertaken to investigate whether inflammation in ATH can induce pyroptosis in vascular smooth muscle cells (SMC's). We therefore hypothesized that pyroptosis occurs and is inhibited by bone morphogenetic protein 7 (BMP7). We examined SMC pyroptosis at acute (D5) and midstage (D28) following disturbed flow-induced hemodynamic injury to the vascular wall using our partial left carotid …
Estimation Of Weaning Patterns In The Elite Meroitic Population (8-B-5.A) From Sai Island, Sudan Using Stable Nitrogen And Carbon Isotopes, Rachel Gregoire
Estimation Of Weaning Patterns In The Elite Meroitic Population (8-B-5.A) From Sai Island, Sudan Using Stable Nitrogen And Carbon Isotopes, Rachel Gregoire
Electronic Theses and Dissertations
This research explores dietary patterns of elite non-adults from the Meroitic period (300 BC – AD 350) located in Sai Island, Sudan. The cemetery (8-B-5.A) is believed to have been in use during the 1st and 2nd centuries AD. Non-adults were chosen because they offer a unique, and often ignored, perspective into customs of past populations. Children require significant energy, which impacts how society feeds and cares for their young. Knowledge of their elite status in society will be consider to explore how this subset of the population may have differed in behavior. A significant factor of child life is …
Using Argument As A Bridge Between Literacy And Science: An Intervention Study In A Science Methods Course For Elementary Preservice Teachers, Rebeca Grysko
Electronic Theses and Dissertations
The purpose of this study was to investigate the impact of an intervention on teaching science as argument within a science methods course on elementary preservice teachers' (PSTs') (a) understandings of the nature of science (NOS), (b) knowledge about argumentation, (c) complexity of their written explanations, and (d) ability to incorporate components of the framework for teaching science as argument to support students' literacy and science learning. This mixed-methods study utilized an embedded quasi-experimental design with a treatment (n = 20) and control group (n = 25). The treatment group instructor, who completed an eight-week professional development course, implemented the …
Seascape Genetics And Rehabilitation Efficiency In The Florida Manatee, Madison Hall
Seascape Genetics And Rehabilitation Efficiency In The Florida Manatee, Madison Hall
Electronic Theses and Dissertations
The Florida manatee (Trichechus manatus latirostris) was recently downlisted federally from "endangered" to "threatened" despite acknowledgments of remaining threats to long term population persistence. Challenges to future manatee conservation include, but are not limited to, increases in frequency of harmful algal blooms, intensifying anthropogenic disturbance, and loss of warm-water habitat. The goals of this dissertation were 1) to assess threats to the manatee via a comprehensive, long-term (1973-2016), retrospective analysis of the manatee rescue and rehabilitation partnership (MRRP) and 2) to use seascape genetics analysis to examine whether abiotic, biotic, or anthropogenic seascape variables could significantly describe genetic distance patterns …
The Role Of Resilience On Second-Victim Outcomes: Examining Individual And External Factors Of Medical Professionals, Claudia Hernandez
The Role Of Resilience On Second-Victim Outcomes: Examining Individual And External Factors Of Medical Professionals, Claudia Hernandez
Electronic Theses and Dissertations
The present work is intended to bring awareness to medical professionals impacted by the occurrence of errors they have committed or witnessed (i.e., second-victims) and highlight the negative effects that may result from such errors. The purpose of this research is to test whether resilience and negative affect that is experienced after a medical error are related. Additionally, four variables are tested as moderators of this relationship, two of which are considered individual variables (i.e., self-efficacy and work meaningfulness), and two of which are characterized as external variables (i.e., co-worker support and organizational support). Twenty-two healthcare professionals from a hospital's …
Use Of Video-Enhanced Debriefing In Clinical Nursing Skill Acquisition: Indwelling Urinary Catheterization As An Exemplar, Erica Hoyt
Electronic Theses and Dissertations
Nursing students struggle to acquire and maintain clinical psychomotor skills. Hiring agencies bear the cost of retraining graduate nurses inept with skills learned early in their nursing curriculum. Improperly performed clinical skills pose a risk to patient safety, resulting in pain and suffering for the patient. This empirical study aimed to determine if video-enhanced debriefing (VED) improved initial skill validation scores, skill feedback, satisfaction with learning, and reduced skill decay among first-semester, pre-licensure BSN students performing female indwelling urinary catheterization (IUC) in a simulated clinical setting compared to no debriefing. Participants received standard instruction, then video-recorded their IUC skill. Participants …
Health Literacy Intervention To Influence Choices Made By Students In A Title I School Who Receive Free Lunch, Melissa Kent
Health Literacy Intervention To Influence Choices Made By Students In A Title I School Who Receive Free Lunch, Melissa Kent
Electronic Theses and Dissertations
This study seeks to influence choices made by Kindergarten students in a Title I school who receive free breakfast and lunch through a health literacy intervention with the intent of decreasing daily added sugar consumption. Fruit and milk choices, either with naturally occurring sugar (NOS) or added sugar (AS), were recorded for 70 Kindergarten students among six classes in a Title I school for ten days before a four-week health literacy intervention. Three of the classes were randomly selected to learn about 'sometimes' and 'anytime' choices through the Healthy Habits for Life curriculum delivered by representatives from Nemours Children's Hospital. …
The Stories Of Transition: A Qualitative Exploration Of International Undegraduate Students' Academic Experiences In First-Year Seminar Courses In The United States, Masa Krsmanovic
Electronic Theses and Dissertations
The purpose of this phenomenological inquiry was to explore how international undergraduate students enrolled in a first-year seminar (FYS) course perceived and described their academic experiences in a large, public university in the southeastern region of the United States. Guided by Schlossberg's (1984) 4 S Transition Model, this qualitative investigation was conducted through in-depth interviews with 10 international undergraduate students representing different countries and academic majors. The participants' narratives revealed that the academic experiences of international first-year students enrolled in the FYS course can be described as challenging, especially in terms of a) understanding U.S. higher education, b) establishing relationships …
Understanding Sediment Biogeochemistry And The Role Of Juvenile Oysters On Recently Restored Eastern Oyster Reefs, Bryan Locher
Understanding Sediment Biogeochemistry And The Role Of Juvenile Oysters On Recently Restored Eastern Oyster Reefs, Bryan Locher
Electronic Theses and Dissertations
In recent decades, goals for the restoration of eastern oyster (Crassostrea virginica) populations along the eastern coast of the United States have shifted from increasing harvestable oyster fisheries to enhancing the range of ecosystem services provided by oyster reefs. By filtering large volumes of water and releasing nutrient-rich feces and pseudofeces, oysters can locally enhance sediment biogeochemical cycling compared to that of unstructured benthic environments. An ongoing restoration program in Mosquito Lagoon, FL was leveraged to assess the immediate impacts ( < 1 year) of restoration on sediment biogeochemical properties of oyster reefs. The first study measured both short-term and long-term pools of carbon, nitrogen and phosphorus on dead, natural and restored reefs periodically over one year. The second study investigated one of the contributions to sediment nutrient pools by comparing feeding and feces/pseudofeces nutrient content of juvenile and older oysters. Results show that inorganic nitrogen and phosphorus pools can change within weeks after restoration and total nutrient pools by 6 months post-restoration. Restored reefs experienced a 136 % increase in ammonium, 78 % increase in total nitrogen, 46 % increase in total phosphorus, and 75 % increase in organic matter concentrations after 12 months of restoration. These nutrient increases were all positively correlated with oyster density, shell length and reef height measured on each reef. When standardized to grams of dry tissue weight, juvenile oysters showed significantly higher rates of chlorophyll-a removal, release of ammonium, and biodeposits with higher concentrations of dissolved organic carbon, nitrite + nitrate, and ammonium. The short-term changes to biogeochemical cycling on eastern oyster reefs within the first year of restoration are important to managers seeking to monitor ecosystem service recovery and overall coastal ecosystem health.
How Do After-School Staff Use Social Networks To Support At-Risk Youth? A Social Capital Analysis, Katherine Philp
How Do After-School Staff Use Social Networks To Support At-Risk Youth? A Social Capital Analysis, Katherine Philp
Electronic Theses and Dissertations
Little is known about the social capital of adults in after-school settings or the ways in which they use social contacts to support youth success, particularly for at-risk youth. Their effectiveness as brokers for learning opportunities may depend on aspects of their social capital: both the quantity and quality of their social networks as well as their attitudes and beliefs related to seeking help from social contacts. This mixed-methods study surveyed 50 after-school program staff serving teens in high-poverty neighborhoods to examine the characteristics of adult social capital and to explore attitudes towards mobilizing social resources to support youth. Surveys …
Remediation Of Chlorinated Alkanes By Zero Valent Iron With Vitamin B12 And Utilization Of A Modified Gradual Release Of Responsibility Model In A Large Enrollment Chemistry Course, Nicole Lapeyrouse
Electronic Theses and Dissertations
The following dissertation looks at addressing environmental contaminants in the environment and the integration of an active learning style in an introductory chemistry course. It begins with addressing the concern for chlorinated propanes and ethane in the environment and the importance of looking into environmental remediation applications. This research looks at incorporating vitamin B12 as an environmentally friendly catalyst in the presence of zero valent iron for the reduction of chlorinated propanes and ethane. Chapter 2 presents the analytical methods and conditions in which samples were run. The results from these experiments are discussed in length in Chapter 3. Our …
A Complete Approach To Predict Biodistribution Of Nanomaterials Within Animal Species From In-Vitro Data, Edward Price
A Complete Approach To Predict Biodistribution Of Nanomaterials Within Animal Species From In-Vitro Data, Edward Price
Electronic Theses and Dissertations
Smart drug-design for antibody and nanomaterial-based therapies allows for optimization of drug efficacy and more efficient early-stage pre-clinical trials. The ideal drug must display maximum efficacy at target tissue sites, but to track and predict distribution to these sites, one must have a mechanistic understanding of the kinetics involved with the individual cells of the tissue itself. This process can be tracked through biological simulations coupled with in-vitro approaches, which result in a rapid and efficient in-depth understanding of drug transport within tissue vasculature and cellular environment. As a result, it becomes possible to predict drug biodistribution within live animal …
Trouble In Paradise: Impacts Of Theme Park Tourism On The Mental Health Of Employees In Orlando, Florida, Lea Harvey
Trouble In Paradise: Impacts Of Theme Park Tourism On The Mental Health Of Employees In Orlando, Florida, Lea Harvey
Electronic Theses and Dissertations
Tourism is a topic that has gained much attention within the realm of anthropology over the past few decades. Anthropological research of the tourism industry has been largely devoted to the study of the tourist gaze and its subsequent sociocultural impacts as well as the benefits that travelers reap from their colonialist excursions. However, the voices of those who form the foundation of this industry, the laborers, remain almost entirely absent from said discourse. Furthermore, there is a lack of anthropological consideration for the relationship between tourism and mental health experiences of employees within the tourism industry. One specific region …
Developing And Validating The Secondary Literacy Professionals Needs Assessment Matrix, Analexis Kennedy
Developing And Validating The Secondary Literacy Professionals Needs Assessment Matrix, Analexis Kennedy
Electronic Theses and Dissertations
The purpose of this study was to develop and validate a needs assessment matrix for secondary specialized literacy professionals that identified the professional learning needs of literacy coaches. This tool was developed in order to inform school districts and secondary specialized literacy professionals about the types of professional learning support they will need for them to effectively meet the literacy needs of teachers in secondary schools. The Secondary Literacy Professionals Needs Assessment Matrix (SLPNAM) was created using a variety of methods. A synthesis of literature regarding school improvement, adolescent literacy, 21st century skills, adult learning, literacy coaching and the 2017 …
Utilizing Asynchronous Online Modules To Educate Preservice Teachers To Address Bullying Behaviors For Elementary Students With Autism Spectrum Disorder, Jaime Best
Electronic Theses and Dissertations
Due to social and communication deficits, individuals with Autism Spectrum Disorder (ASD) are targeted for school bullying more than other populations. With an increased number of individuals with ASD being served in general education classrooms, teachers are at the front line of defense for this vulnerable population. Many teachers and preservice teachers lack experience and self-confidence when dealing with situations related to individuals with ASD in their inclusive classrooms. While research on educating preservice teachers to deal with bullying behaviors is limited, the importance of providing high-quality teacher preparation programs for upcoming teachers remains at the upmost importance. The purpose …
Designing Calorie Counter Smartphone Applications For Effective Weight Loss, Sharlin Milliard
Designing Calorie Counter Smartphone Applications For Effective Weight Loss, Sharlin Milliard
Electronic Theses and Dissertations
Poor dietary choices and lack of physical activity are two main contributing factors for the increasing prevalence of overweight and obesity in the United States. Overweight and obese individuals are at risk for developing major life-threatening diseases. Weight loss is an effective means for reversing these adverse health effects, and smartphone applications (apps) may be an effective means for supporting weight loss outside of formal clinical settings. This study involved identifying factors that contribute to effective weight loss to compare with functionality commonly found in a sample of calorie counter apps. A content analysis was performed using a design framework …
Neurological Reactivity To Personalized Odors And Sounds In Combat-Related Posttraumatic Stress Disorder, Michael Gramlich
Neurological Reactivity To Personalized Odors And Sounds In Combat-Related Posttraumatic Stress Disorder, Michael Gramlich
Electronic Theses and Dissertations
Functional near-infrared spectroscopy (fNIRS) is a neurophysiological procedure that offers immense clinical utility due to its cost effectiveness, ease of use, and mobile application. Using fNIRS to measure neurological reactions to personalized trauma-related cues might strengthen diagnostic screening, tailor treatment planning, and improve detection of remission among individuals with posttraumatic stress disorder (PTSD). Odors elicit strong emotional responses but remain underutilized in clinical research. This fNIRS study examined whether personalizing combat-related odors and sounds to have a higher or lower match to distressing combat experiences increased the observed neurological effect among combat veterans with and without combat-related PTSD. This study …
Development Of Multiport Single Stage Bidirectional Converter For Photovoltaic And Energy Storage Integration, Amit Bhattacharjee
Development Of Multiport Single Stage Bidirectional Converter For Photovoltaic And Energy Storage Integration, Amit Bhattacharjee
Electronic Theses and Dissertations
The energy market is on the verge of a paradigm shift as the emergence of renewable energy sources over traditional fossil fuel based energy supply has started to become cost competitive and viable. Unfortunately, most of the attractive renewable sources come with inherent challenges such as: intermittency and unreliability. This is problematic for today's stable, day ahead market based power system. Fortunately, it is well established that energy storage devices can compensate for renewable sources shortcomings. This makes the integration of energy storage with the renewable energy sources, one of the biggest challenges of modern distributed generation solution. This work …
Role Of Tnfα Antagonists And Genetic Polymorphisms In Modulating Susceptibility To Mycobacterial Infection Among Patients With Crohn's Disease, Ahmad Qasem
Electronic Theses and Dissertations
Tumor Necrosis Factor alpha antagonists (anti-TNFα) have been extensively used for Crohn's disease (CD) treatment. Even though they may control CD symptoms initially, treatment response varies among patients, which seems to depend on single nucleotide polymorphisms (SNPs) in TNFα receptors superfamily 1A and 1B (TNFRSF1A/B). Most importantly, M. tuberculosis infection has been strongly associated with these medications, but no studies have elucidated the effects of anti-TNFα on CD associated with MAP (Mycobacterium avium subspecies paratuberculosis; a possible causative agent of CD, and closely related to M. tuberculosis). Here, we investigated the effects of recombinant inflammatory cytokines and anti-TNFα therapeutics on …