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Articles 5101 - 5130 of 1791685
Full-Text Articles in Entire DC Network
Phenomenological Exploration Of The Military Veterans' Experiences Transitioning Into Civilian Workplace In Central Florida, James Wesley Shelton
Phenomenological Exploration Of The Military Veterans' Experiences Transitioning Into Civilian Workplace In Central Florida, James Wesley Shelton
Walden Dissertations and Doctoral Studies
Military veterans transitioning from military service to civilian employment frequently encounter challenges related to workforce integration, translating military-acquired skills, adapting to civilian workplace cultures, and employer perceptions of their qualifications. Organizational leaders need to understand these challenges as a key indicator of the factors that influence successful workforce integration, organizational commitment, and employee retention. Grounded in person-environment fit theory, the purpose of this qualitative study using an interpretative phenomenological analysis (IPA) approach was to explore the lived experiences of military veterans and how they make meaning of their transition to the civilian workplace. The participants comprised seven U.S. military veterans …
Fisheries Research Report No. 365: Recreational Fishing For Marron In South-West Western Australia In 2026, Claire B. Smallwood, Karina L. Ryan, Eva Lai
Fisheries Research Report No. 365: Recreational Fishing For Marron In South-West Western Australia In 2026, Claire B. Smallwood, Karina L. Ryan, Eva Lai
Fisheries Research Reports
The smooth marron (Cherax cainii) (‘marron’) is endemic to freshwater dams and rivers of south-west Western Australia. Marron are managed as a single stock within the South-West Recreational Freshwater Resource and are highly vulnerable to overexploitation due to the biological characteristics of the species (e.g., low fecundity, localised populations) as well as environmental (e.g., habitat loss, reduction in rainfall) and human (e.g., fishing, land clearing) pressures on freshwater ecosystems.
Due to this vulnerability, this species has been the focus of research, monitoring and management since the 1970’s. Since 2000, annual phone-recall (2000 – 2021) and online-recall (2022 – 2026) surveys …
Sexual Grooming And Other Barriers To Disclosure Of Childhood Sexual Abuse, Lillian A. Steedman
Sexual Grooming And Other Barriers To Disclosure Of Childhood Sexual Abuse, Lillian A. Steedman
Theses, Dissertations and Culminating Projects
Child sexual abuse is a serious and prevalent problem in the United States and is associated with negative consequences across numerous life domains (e.g., psychological, physical, socioeconomic). Disclosure of sexually abusive experiences may facilitate victims’ abilities to obtain psychological, social, and legal support. It has been theorized that sexual grooming plays a role in decreasing the likelihood of disclosure and of disclosures being believed. Therefore, this dissertation examined associations among sexual grooming, other barriers, and disclosure decisions and timing. Participants were recruited and screened online for eligibility to participate in a survey examining details of the abuse, trauma-related shame, disclosure …
Our Honors Impact: Evidence Of Honors Student Experience And Outcomes, 01 - The Initial Evidence Review, Brian Hoey, Honors College
Our Honors Impact: Evidence Of Honors Student Experience And Outcomes, 01 - The Initial Evidence Review, Brian Hoey, Honors College
Publications of the Honors College at Marshall University
Our Honors Impact, 01: Evidence of Honors Student Experience and Outcomes presents an initial review of student-centered evidence collected by the Honors College at Marshall University through its developing Honors Impact Evidence Bank. Drawing on student reflections, supported-project deliverables, program assessments, profiles, and other documented experiences, the report examines how honors education is experienced in practice and what becomes possible through integrative and experiential learning, mentorship, peer connection, financial support, global engagement, and opportunities for independent inquiry. Student narratives illustrate recurring patterns of intellectual growth, confidence, belonging, professional development, and connection to Appalachia and West Virginia. As the first edition …
The Nature Of Human Trafficking Enterprises: Analysis Of U.S. And International Prosecutions--And The Path Forward, Jay Albanese
The Nature Of Human Trafficking Enterprises: Analysis Of U.S. And International Prosecutions--And The Path Forward, Jay Albanese
Dignity: A Journal of Analysis of Exploitation and Violence
The primary objective of this research is to develop a description and typology of the nature of serious cases of human trafficking and how traffickers, their victims, and consumers (the demand) overlap and interact across locations. This study examines known human trafficking enterprises for which sufficient evidence has been obtained to result in prosecution. These are also serious cases because US federal and international prosecutions result when the offenses are interstate or international in scope. Using a sample of US cases prosecuted over three calendar years (2021-2024), combined with an international sample of cases, an effort is made to develop …
Impunity: A Case Study Of Sex Trafficking In Nevada Brothel Prostitution, Christen Price
Impunity: A Case Study Of Sex Trafficking In Nevada Brothel Prostitution, Christen Price
Dignity: A Journal of Analysis of Exploitation and Violence
It is well-documented that legalization and other forms of official protection for prostitution lead to an increase in sex trafficking, including by encouraging demand for prostitution. This paper will consider the relationship between official protection, organized crime, and sex trafficking in pro-prostitution legal regimes, both historical and contemporary. Prostitution is legal in rural counties in Nevada that have fewer than 700,000 residents, if prostitution occurs within a brothel. There is significant overlap between sex trafficking and legal brothel prostitution in Nevada, as well as a nexus to corruption and organized crime, illustrating the normalization of coercion that occurs within legalized …
Disrupting The Demand For Commercial Sex To Combat Sex Trafficking And Destabilise Organised Crime Networks, Johan Van Graan
Disrupting The Demand For Commercial Sex To Combat Sex Trafficking And Destabilise Organised Crime Networks, Johan Van Graan
Dignity: A Journal of Analysis of Exploitation and Violence
Sex trafficking persists as a lucrative form of organised crime, sustained by ongoing demand for commercial sex. Using Rational Choice Theory, this article reframes sex buyers as active perpetrators and financial drivers of trafficking networks rather than peripheral actors. The article examines how buyers weigh risks and benefits when purchasing sex, especially in contexts with weak law enforcement. By analysing 53 active trafficking cases from 2021 and 36 prosecuted cases in South Africa (2007–2022), the research identifies clear patterns in buyer behaviour, network operations, and law‑enforcement responses. A central finding is the near-total absence of buyers in prosecutions, which reinforces …
Leveraging Technology To Measure The Strength Of Demand For Commercial And Trafficked Sex, Michael D. Shively, Bob Rodgers, Courtney Furlong, Brooke Ruffin
Leveraging Technology To Measure The Strength Of Demand For Commercial And Trafficked Sex, Michael D. Shively, Bob Rodgers, Courtney Furlong, Brooke Ruffin
Dignity: A Journal of Analysis of Exploitation and Violence
The article examines Transaction Intercept (TI), an artificial‑intelligence platform designed to reduce sex trafficking by disrupting the revenue streams that draw organized crime into the market. Transaction Intercept deploys decoy online ads that appear to offer commercial sexual exploitation or prostitution. Automated "decoy" personas connect to individuals who click on these ads and engage them in text conversations. These exchanges can remain fully automated, ending with deterrence messages, or be transferred to police for potential enforcement action or to trained volunteers who attempt to discourage further attempts to buy sex. Transaction Intercept generates extensive, real‑time data on local demand for …
Project Care Poster, Jeff Gutierrez, Rayna Sage, Rtc: Rural
Project Care Poster, Jeff Gutierrez, Rayna Sage, Rtc: Rural
Independent Living and Community Participation
The CARE Project connects rural Centers for Independent Living (CILs) and rural libraries to improve disability services and respond to community needs together. RTC:Rural has designed a participatory curriculum development project to collaboratively create a resource to provide a roadmap to community partnerships between rural CILs and libraries.
The Impact Of Point Of Care Hepatitis C Virus Rna Testing On Diagnosis, Treatment Initiation, And Linkage To Care In Marginalized Populations, Maria Simpson
Medical Laboratory Science Independent Study Projects
Hepatitis C virus (HCV) remains a major public health concern, particularly among marginalized and high-risk populations who experience barriers to timely diagnosis, treatment initiation, and linkage to care. Traditional laboratory-based HCV testing often requires multistep workflows and follow-up visits, contributing to delayed confirmation of active infection and loss to care. This literature review examines how point-of-care HCV ribonucleic acid (RNA) testing affects time to diagnosis, treatment initiation, and linkage to care compared with standard laboratory-based testing. Evidence from systematic reviews, community-based trials, correctional settings, supervised consumption sites, diagnostic performance studies, and cost-effectiveness analyses indicates that point-of-care RNA testing shortens turnaround …
Standardized Training Methodologies For Medical Laboratory Science Students And Their Importance For Student Success, Maria Simpson
Standardized Training Methodologies For Medical Laboratory Science Students And Their Importance For Student Success, Maria Simpson
Medical Laboratory Science Independent Study Projects
Clinical education is a critical component of Medical Laboratory Science (MLS) programs, serving as the primary bridge between academic instruction and professional practice. However, traditional clinical rotation training models often struggle to keep pace with rapid advancements in laboratory technology, expanding professional responsibilities, workforce shortages, and heightened patient safety expectations. The purpose of this capstone project is to examine the key factors driving the need to update training methodologies in MLS clinical rotations and to evaluate contemporary educational approaches that better prepare students for entry-level practice. This project addresses systemic challenges faced by clinical laboratories, such as staffing constraints, heavy …
From Centralized To Decentralized Care: Assessing The Role Of Design In Cardiovascular Unit Performance, Lindsey Fay
From Centralized To Decentralized Care: Assessing The Role Of Design In Cardiovascular Unit Performance, Lindsey Fay
Interiors Faculty Publications
This report presents a comprehensive pre- and post-occupancy evaluation of the University of Kentucky HealthCare Cardiovascular Unit, conducted through a collaborative effort between the College of Design, College of Communication and Information, UK HealthCare, and GBBN Architects. The study examines the transition from a centralized to a decentralized care delivery model within a newly constructed hospital environment, with the goal of understanding how spatial design influences healthcare delivery, staff performance, and patient experience.
Using a mixed-methods approach, the research integrates quantitative and qualitative data collection techniques, including behavioral mapping, communication tracking, pedometer data, acoustic measurements, and staff and user feedback. …
Rural/Urban Disparities In Utilization Of Diabetes Self-Management Training (Dsmt) To The Fee-For-Service Medicare Population, 2017–2024, Wanying Zhu, Aleksandr Taraskin, Jeffrerey Talbert
Rural/Urban Disparities In Utilization Of Diabetes Self-Management Training (Dsmt) To The Fee-For-Service Medicare Population, 2017–2024, Wanying Zhu, Aleksandr Taraskin, Jeffrerey Talbert
Rural & Underserved Health Research Center Publications
Key Report Highlights
• A significant rural DSMT access gap exists. Rural beneficiaries accounted for 20.1% of Medicare beneficiaries with diabetes but only 7.8% of DSMT participants.
• Geographic availability remains limited. Only 16.8% of counties with DSMT utilization were rural.
• Access, not demand, appears to be the primary challenge. Rural counties offering DSMT achieved utilization rates more than twice those observed in urban counties (6.0% vs. 2.5%).
• Expanding rural DSMT capacity may represent a high-impact opportunity to improve diabetes self-management support among underserved Medicare beneficiaries.
Non-Metropolitan Vs. Metropolitan Variations In Alcohol, Illicit Drug, And Prescription Therapeutic Drug Misuse, Tyrone F. Borders
Non-Metropolitan Vs. Metropolitan Variations In Alcohol, Illicit Drug, And Prescription Therapeutic Drug Misuse, Tyrone F. Borders
Rural & Underserved Health Research Center Publications
Key Findings
Alcohol Use. The prevalence of past year and past 30-day drinking was lower among non-metropolitan (non-metro) than metropolitan (metro) residents. However, non-metro drinkers engaged in more frequent binge drinking than metro drinkers. Drinking 3-5, 6-19, and 20-30 days over the past 30 days were higher among non-metro than metro residents.
Illicit Drug Use. Hallucinogens were the mostly commonly used illicit drugs among non-metro as well as metro residents. Methamphetamine use was significantly higher among non-metro than metro residents.
Prescription Pain Reliever Use. The misuse of prescription pain killers, primarily prescription opioids, was higher among non-metro than …
High-Deductible Health Plans In Rural And Urban Populations: Outpatient Utilization And Out-Of-Pocket Costs, Aaron P. Smith, Jefferey Talbert
High-Deductible Health Plans In Rural And Urban Populations: Outpatient Utilization And Out-Of-Pocket Costs, Aaron P. Smith, Jefferey Talbert
Rural & Underserved Health Research Center Publications
Overview of Key Findings This policy brief explores rural-urban differences in High-Deductible Health Plan (HDHP) enrollment, subsequent healthcare utilization, and out-of-pocket (OOP) costs. ▪ HDHP enrollment was uncommon. Rural residents were slightly less likely to enroll than urban residents across all demographic groups. ▪ Switching plans influenced utilization. Compared to those who did not change healthcare plans, switching from a Traditional plan to a HDHP was associated with a larger reduction in 2022 outpatient visits for both rural and urban residents. Moving from a HDHP to a Traditional plan was associated with a smaller reduction in 2022 outpatient visits for …
Data Centers Face Volatile Regulatory Landscape, Michael B. Gerrard
Data Centers Face Volatile Regulatory Landscape, Michael B. Gerrard
Sabin Center for Climate Change Law
The construction of new data centers for artificial intelligence has become a major engine of the U.S. economy. More than 700 data centers are now under construction across 40 states, with many more to come.
These are typically multi-billion-dollar projects. This boom is facing growing public opposition, which has led to an extremely volatile regulatory land-scape, especially at the state and local levels. That landscape is the subject of this article. This volatility has raised the cost of capital for data centers and led to the cancellation of many, and to heightened due diligence by lenders and others.
Telling Their Intensive Stories: Black/African American Intensive Care Unit Nurses And Their Perceived Encounters With Icu Workplace Racism, Sharon M. Butler
Telling Their Intensive Stories: Black/African American Intensive Care Unit Nurses And Their Perceived Encounters With Icu Workplace Racism, Sharon M. Butler
Theses & Dissertations
The 2022 American Nurses Association (ANA) study on racism and racial inequality within the nursing profession both acknowledges the presence of racism in nursing and provides evidence of the diverse negative social and psychological effects of racism on minority nurses. Although the 2022 ANA study sets a precedent and shows evidence of racism’s effects across the broader professional nursing workforce, there is limited nursing research literature that offers a focused presentation and understanding of the lived experiences of minority nurses and their personal perceptions of workplace racism. There is also limited nursing research on how workplace racism impacts cultural and …
Nurse Manager Perceptions Of Strategies To Overcome The Underutilization Of Nonpharmacological Pain Control Methods In Adult Acute Care, Landen M. Bonnell
Nurse Manager Perceptions Of Strategies To Overcome The Underutilization Of Nonpharmacological Pain Control Methods In Adult Acute Care, Landen M. Bonnell
Undergraduate Honors Theses
A basic patient right is to have pain adequately managed. However, research consistently indicates that many adult patients in acute care experience inadequately managed pain, which may contribute to adverse patient outcomes. Studies have shown that nonpharmacological pain management can lead to increased patient satisfaction, shorter hospital stays, and better patient outcomes. However, many barriers exist to nurses providing effective nonpharmacological pain control therapy, primarily including heavy workload and a lack of education and support. Currently, there is insufficient research on how to overcome these barriers. Four nurse managers with experience in nursing leadership were interviewed using a qualitative descriptive …
Climate Change And Adolescent Girls In West And Central Africa: Building A Girl-Intentional Response, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Climate Change And Adolescent Girls In West And Central Africa: Building A Girl-Intentional Response, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
The Girls’ Futures in Focus: Evidence from West and Central Africa series examines the challenges facing adolescent girls in the region and highlights evidence-informed approaches to improving their lives. This brief summarizes the evidence on how climate shocks reshape the lives of adolescent girls in West and Central Africa, drawing in particular on evidence from the GIRL Center’s priority countries. It examines gendered climate vulnerabilities, gaps in climate policies that overlook girls, and emerging adaptation strategies that hold promise for girls in the region. The brief points to what a girl-intentional climate response could look like across the priority countries.
Adolescentes En Afrique De L’Ouest Et Du Centre : Trajectoires, Risques Et Leviers De Changement, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescentes En Afrique De L’Ouest Et Du Centre : Trajectoires, Risques Et Leviers De Changement, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
La série « L’avenir des filles en point de mire : données probantes d’Afrique de l’Ouest et du Centre » examine les défis auxquels sont confrontées les adolescentes de la région et met en lumière des approches fondées sur des données probantes pour améliorer leur quotidien. Cette note de synthèse examine leur éducation, leur autonomisation économique, leur santé mentale, leur santé sexuelle et reproductive, leur accès au numérique et leurs usages technologiques, ainsi que leurs besoins face au changement climatique et dans des contextes humanitaires. En s’appuyant sur des données issues des pays prioritaires du GIRL Center, elle identifie les …
Changement Climatique Et Adolescentes En Afrique De L’Ouest Et Du Centre : Vers Une Réponse Centrée Sur Les Filles, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Changement Climatique Et Adolescentes En Afrique De L’Ouest Et Du Centre : Vers Une Réponse Centrée Sur Les Filles, Mame Soukeye Mbaye, Sarah Engebretsen, Maty Dia, Karen Austrian
Adolescents and Young People
La série « L’avenir des filles en point de mire : données probantes d’Afrique de l’Ouest et du Centre » examine les défis auxquels font face les adolescentes de la région et met en lumière des approches éclairées par les données probantes pour améliorer leurs conditions de vie. Cette note de recherche synthétise les données probantes sur la manière dont les chocs climatiques bouleversent la vie des adolescentes en Afrique de l’Ouest et du Centre (AOC), en s’appuyant notamment sur les données issues des pays prioritaires du GIRL Center. Elle examine les vulnérabilités climatiques liées au genre, les lacunes des …
Online Group Neurobehavioral Therapy (Nbt) For Veterans With Epilepsy And Major Depressive Disorder (Mdd), Melissa F. Fadipe
Online Group Neurobehavioral Therapy (Nbt) For Veterans With Epilepsy And Major Depressive Disorder (Mdd), Melissa F. Fadipe
Dissertations and Theses (Open Access)
Background: Veterans with epilepsy experience high rates of psychiatric comorbidity, most commonly major depressive disorder (MDD). Barriers to accessing mental health care—including geographic distance, transportation limitations related to seizure-related driving restrictions, and fragmented care between neurology and psychiatry, contribute to the underdiagnosis and undertreatment of MDD in this population. Neurobehavioral Therapy (NBT), a Cognitive Behavioral Therapy (CBT)-informed psychotherapy developed for individuals with seizures, has demonstrated benefits for psychological distress and quality of life. Internet-based interventions and short message service (SMS) text messaging offer promising strategies to address access barriers; however, limited research has examined the feasibility and acceptability of delivering …
Baseline Nutrition Knowledge And Feasibility Of A Whatsapp-Delivered Nutrition Education Intervention Among California Wildland-Urban Interface Firefighters, Lauren E. Anderson
Baseline Nutrition Knowledge And Feasibility Of A Whatsapp-Delivered Nutrition Education Intervention Among California Wildland-Urban Interface Firefighters, Lauren E. Anderson
Master's Theses
Wildland firefighters perform physically demanding work under challenging environmental conditions that place substantial demands on nutritional health and occupational performance. Despite the importance of nutrition in supporting physical performance, recovery, and long-term health, limited research has examined nutrition knowledge and dietary behaviors among California wildland firefighters or evaluated the feasibility of remotely delivered nutrition education interventions within this occupational population. Therefore, the purpose of this pilot study was to assess baseline nutrition knowledge, nutrition self-efficacy, and dietary behaviors while evaluating the feasibility of a 12-week WhatsApp-delivered nutrition education intervention among California wildland firefighters.
Twenty-four firefighters completed the baseline assessment and …
Locus Coeruleus Tdp-43 Pathology In A Community-Based Cohort, Allison M. Neltner, Ryan K. Shahidehpour, Megan E. Hall, Xiaotong Ning, Shuling Fister, Hannah Kang, Sonya Anderson, Gregory A. Jicha, Tiffany L. Lee, Erin L. Abner, David W. Fardo, Peter T. Nelson
Locus Coeruleus Tdp-43 Pathology In A Community-Based Cohort, Allison M. Neltner, Ryan K. Shahidehpour, Megan E. Hall, Xiaotong Ning, Shuling Fister, Hannah Kang, Sonya Anderson, Gregory A. Jicha, Tiffany L. Lee, Erin L. Abner, David W. Fardo, Peter T. Nelson
Epidemiology and Environmental Health Faculty Publications
The locus coeruleus (LC) is the source of norepinephrinergic innervation in the human brain. Locus coeruleus pathology has been linked to clinical conditions such as cognitive impairment and behavioral and psychiatric symptoms of dementia (BPSD). However, phosphorylated TDP-43 (pTDP-43) pathology in the LC has been understudied, particularly in the contexts of aging and limbic predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC). Here, a convenience sample (n = 134) of autopsied participants from the University of Kentucky Alzheimer’s Disease Research Center community-based cohort was analyzed for LC pTDP-43 and phosphorylated tau (pTau) pathologies. Locus coeruleus pTDP-43 pathology was found in 28/134 …
Mir155, Triplicated In Down Syndrome, Regulates The Development Of Neural Stem Cells And Gabaergic Interneurons In Alzheimer's Disease Mouse And Human Ipsc Models., Xiaodong Zhu, Jean-Vianney Haure-Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al-Subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E Ehrlich
Mir155, Triplicated In Down Syndrome, Regulates The Development Of Neural Stem Cells And Gabaergic Interneurons In Alzheimer's Disease Mouse And Human Ipsc Models., Xiaodong Zhu, Jean-Vianney Haure-Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aiqun Li, Aisha Al-Subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E Ehrlich
Faculty Research 2026
INTRODUCTION: Dysfunctional microRNAs and GABAergic interneurons are features of Alzheimer's disease (AD). The role of neuronal microRNA155 (miR155), elevated in both AD and Down syndrome (DS), remains unknown.
METHODS: We utilized in silico analyses of published databases, MIR155-deleted and -overexpressing human induced pluripotent stem cell (hiPSC)-derived cells, cortical organoids, and amyloid beta precursor protein (APP)/PS1-miR155 knockout mouse.
RESULTS: MIR155HG (miR155 host gene) colocalizes with APP in a neuron-specific, topologically associated domain (TAD) in chromosome 21. In human neural stem cells (NSCs), neurons, and cortical organoids, MIR155 deletion enhanced NSC proliferation and GABAergic interneuron generation. MIR155 overexpression inhibited NSC marker expression …
The Past, The Present, And The Future Of Preclinical Mouse Models For Alzheimer's Disease And Related Dementias., Adrian L Oblak, Michael Sasner, Gregory W. Carter, Gareth R Howell, Stacey J Sukoff Rizzo, Karina Leal, Paul R Territo, Bruce T Lamb
The Past, The Present, And The Future Of Preclinical Mouse Models For Alzheimer's Disease And Related Dementias., Adrian L Oblak, Michael Sasner, Gregory W. Carter, Gareth R Howell, Stacey J Sukoff Rizzo, Karina Leal, Paul R Territo, Bruce T Lamb
Faculty Research 2026
Over the past decade, the Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease (MODEL-AD) consortium has transformed preclinical Alzheimer's disease (AD) research by addressing critical limitations in traditional mouse models that failed to translate to human disease. By leveraging human genetic discoveries, MODEL-AD has developed > 70 genetically informed mouse models, standardized phenotyping pipelines, and an open-access data infrastructure aligned with late-onset AD biology. These models incorporate human risk variants, environmental factors, and aging to better capture disease complexity, including emerging recognition of mixed pathologies such as vascular contributions, Lewy body disease, and TDP-43 proteinopathy. Despite substantial progress, key challenges …
A Collaborative Framework For Uncovering Molecular And Cellular Drivers Of Vcid: Foundations For Future Interventions In Dementia., M Luisa Iruela-Arispe, Jason D Hinman, Andrew C Yang, Fabrice Dabertrand, Jin-Moo Lee, Gareth R Howell, The Vcid Centers Without Walls Network
A Collaborative Framework For Uncovering Molecular And Cellular Drivers Of Vcid: Foundations For Future Interventions In Dementia., M Luisa Iruela-Arispe, Jason D Hinman, Andrew C Yang, Fabrice Dabertrand, Jin-Moo Lee, Gareth R Howell, The Vcid Centers Without Walls Network
Faculty Research 2026
Vascular-related factors are now considered major contributors to most forms of dementia, including Alzheimer's disease. However, the degree to which vascular deficits contribute to risk, onset, and progression of cognitive impairment and dementia has only recently been appreciated. Our understanding of the mechanisms by which vascular deficits drive cognitive decline in dementia is still limited. Further, the testing of therapeutic approaches to prevent vascular deficits to treat dementia are few. These factors motivated the establishment of the Vascular Contributions to Cognitive Impairment and Dementia (VCID) Center Without Walls (CWOW) network, comprising institutes across the United States. We describe the current …
Worldwide Innovative Network Consortium: Building A Common Global Cancer Database., Farhood Farahnak, Wafik S El-Deiry, Yves A Lussier, Razelle Kurzrock, Shai Magidi, Catherine Bresson, Shirin A Enger, Jia Liu, Jair Bar, Jeremy L Warner, Tobias Meissner, Eitan Rubin, Jens Rueter, Himabindu Gaddipati, Mandar Kulkarni, Zhen Chen, Sewanti Limaye, Rachel Elsey, Brenda M Rubenstein, Anthony M Joshua, Humaid O Al-Shamsi, Khaled M Musallam, Fanny Wunder, Jacques Raynaud, Guy Berchem, Manon Gantenbein, Amal Al Omari, Said Dermime, Hikmat Abdel-Razeq, Pierre Saintigny, Andrés Cervantes, Roger R Reddel, Adel T Aref, Juan Martin-Liberal, Conxi Lázaro, David Cordero Romera, Marina Sekacheva, Raanan Berger, C S Pramesh, Ioana Berindan-Neagoe, Eugenia Girda, Alejandro Piris-Gimenez, Carol J Farhangfar, Mohammed E Salem, Rodrigo Dienstmann, Ramon Salazar, Naftali Z Frankel, Zachary Batist, Yuri Quintana, Gerald Batist
Worldwide Innovative Network Consortium: Building A Common Global Cancer Database., Farhood Farahnak, Wafik S El-Deiry, Yves A Lussier, Razelle Kurzrock, Shai Magidi, Catherine Bresson, Shirin A Enger, Jia Liu, Jair Bar, Jeremy L Warner, Tobias Meissner, Eitan Rubin, Jens Rueter, Himabindu Gaddipati, Mandar Kulkarni, Zhen Chen, Sewanti Limaye, Rachel Elsey, Brenda M Rubenstein, Anthony M Joshua, Humaid O Al-Shamsi, Khaled M Musallam, Fanny Wunder, Jacques Raynaud, Guy Berchem, Manon Gantenbein, Amal Al Omari, Said Dermime, Hikmat Abdel-Razeq, Pierre Saintigny, Andrés Cervantes, Roger R Reddel, Adel T Aref, Juan Martin-Liberal, Conxi Lázaro, David Cordero Romera, Marina Sekacheva, Raanan Berger, C S Pramesh, Ioana Berindan-Neagoe, Eugenia Girda, Alejandro Piris-Gimenez, Carol J Farhangfar, Mohammed E Salem, Rodrigo Dienstmann, Ramon Salazar, Naftali Z Frankel, Zachary Batist, Yuri Quintana, Gerald Batist
Faculty Research 2026
This review shares the ongoing work of the global Worldwide Innovative Network (WIN) Consortium for Precision Medicine to synthesize emerging cancer treatment data and to define the requirements for a common global cancer database that can truly support precision oncology. We performed a narrative review of emerging cancer treatment data, molecular profiling technologies, and existing clinicogenomic databases, focusing on how tumors are characterized, how subgroups are defined, and how demographic, lifestyle, and environmental factors are captured. The growth in molecular profiling technologies and the development of new targeted therapies are transforming cancer care. Tumors, regardless of tissue origin, are increasingly …
Inhibition Of Moesin And Cd44 In Stem Cell-Derived Neurons Affects The Pathological Genetic Signature Associated With Alzheimer's Disease., Eiden H Brewer, Charles A Williams, Gregory Cary, Ranjita Betarbet, Inez K A Pranoto, Elizabeth L Zoeller, Haian Fu, Allan I Levey, Jesse C Wiley, Gregory W. Carter, Jessica E Young, Treat-Ad Consortium
Inhibition Of Moesin And Cd44 In Stem Cell-Derived Neurons Affects The Pathological Genetic Signature Associated With Alzheimer's Disease., Eiden H Brewer, Charles A Williams, Gregory Cary, Ranjita Betarbet, Inez K A Pranoto, Elizabeth L Zoeller, Haian Fu, Allan I Levey, Jesse C Wiley, Gregory W. Carter, Jessica E Young, Treat-Ad Consortium
Faculty Research 2026
INTRODUCTION: Post mortem proteomic analysis of Alzheimer's disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced pluripotent stem cells (hiPSCs)-derived neurons, we assayed how reducing gene expression of MSN and CD44 affected amyloid beta secretion, tau phosphorylation, and transcriptional state.
METHODS: Knockdown of MSN and CD44 in hiPSC-derived neurons was performed using short hairpin RNA (shRNA). Amyloid precursor protein processing and intracellular tau phosphorylation was measured using chemiluminescent ELISA assays. Global gene expression was analyzed by bulk RNA sequencing (RNA-seq).
RESULTS: Knockdown …
The Internet Did This To Me: Forms, Consequences, And Coping Strategies Of Cyberbullying, Isaac Oppong
The Internet Did This To Me: Forms, Consequences, And Coping Strategies Of Cyberbullying, Isaac Oppong
Electronic Theses and Dissertations
This study examined self-reported cyberbullying experiences recounted in a subreddit (r/cyberbullying) to identify forms of cyberbullying, its effects, and ways to cope with it. The findings indicate that there are several types of cyberbullying, such as verbal aggression, deceptive manipulation, privacy invasion, and coercive control. These experiences led to emotional, social, and behavioral consequences, including fear, anxiety, withdrawal, and decreased online activity. Based on concepts from Social Information Processing theory and Symbolic Interactionism, this study reveals how cyberbullying can produce the same or similar consequences as traditional bullying. People experienced disturbances in their self-presentation, contended with spoiled identities, and dealt …