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Articles 5071 - 5100 of 15385
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The Relationship Between Intra-Cultural Factors And Feedback Seeking Behavior In Supervision Among Counselors-In-Training In Counselor Education Programs, Sumedha Therthani
The Relationship Between Intra-Cultural Factors And Feedback Seeking Behavior In Supervision Among Counselors-In-Training In Counselor Education Programs, Sumedha Therthani
Electronic Theses and Dissertations
For this research study a cross-sectional correlational survey research design was utilized. Counselors in training both master and doctoral level currently receiving clinical supervision in counselor education programs (n=123) participated in this study. Participants were administered (a) tolerance of ambiguity scale (b) individual power distance scale (c) feedback-seeking frequency scale (d) feedback-seeking source scale and (e) feedback-seeking style scale. Six research questions were the subject of data analyses in this study. Analyses included conducting multivariate multiple regression and simple regression analyses to understand whether tolerance of ambiguity and status identity predict graduate counselors’ feedback-seeking (a) style (b) source and (c) …
Comparative Assessment Of Safety And Quality Of Tinospora Species-Tinospora Crispa And Tinospora Sinensis, Abidah Parveen
Comparative Assessment Of Safety And Quality Of Tinospora Species-Tinospora Crispa And Tinospora Sinensis, Abidah Parveen
Electronic Theses and Dissertations
Tinospora crispa Miers ex Hook.f. & Thomson and Tinospora sinensis (Lour.) Merr. (Menispermaceae) are two species that have morphological similarities which makes distinction between the two of critical importance because T. crispa has been reported to cause hepatotoxicity. Comparative morpho-anatomy of the leaves and stems of Tinospora species indigenous to south and southeast Asia was undertaken to elaborate their distinguishing pharmacognostic features. Chemical characterization of the secondary metabolites of the two species may aid in elucidating their chemical diversity and hence help to resolve safety and quality issues. Phytochemical investigation of the stems led to the isolation of nineteen compounds …
African American Students In Physical Therapy: Enhancing Diversity, Kimberly Renee Willis
African American Students In Physical Therapy: Enhancing Diversity, Kimberly Renee Willis
Electronic Theses and Dissertations
African Americans are motivated by early exposure to the profession and future expectations for their personal career path including stability work-life balance and helping others. The elimination of barriers such as finances lack of support and cultural microaggressions influences their career path. Following statistical analysis of admissions data conclusions were made that the current admissions criteria does not successfully predict first year success for any students including African American students. Lastly African American physical therapy graduates from UMMC reported excitement upon admission concerns over quotas lack of African American faculty students and physical therapists and the presence of microaggressions while …
Role Of Cardiolipin Remodeling In The Malignant Progression Of Breast Cancer, Jawaher H. Alkhamisy
Role Of Cardiolipin Remodeling In The Malignant Progression Of Breast Cancer, Jawaher H. Alkhamisy
Electronic Theses and Dissertations
In spite of the current advances in both radiotherapy and surgical techniques as well as molecularly targeted therapies, over 90 percent of cancer mortality rate is due to metastases. Considering the pivotal role of metabolism in cellular physiology, there is no doubt that metabolic alterations are critical for metastatic progression. Cardiolipin (CL), the signature phospholipid of mitochondria, is linked to a variety of vital mitochondrial processes, like oxidative phosphorylation. Cardiolipin is a unique dimeric phospholipid which contains four fatty acyl chains. Moreover, the CL remodeling process is believed to be responsible for generation of immature CL species that contribute to …
Youth Screening Protocol For General Psychopathology, Steven Bishop
Youth Screening Protocol For General Psychopathology, Steven Bishop
Electronic Theses and Dissertations
There is a high prevalence rate of psychopathology among US youth, with at least one in four youth meeting clinical criteria for a mental health condition. Those youths who experience psychopathology tend to demonstrate greater functional impairments and have more adverse outcomes compared to youth who do not have these frequently occurring conditions. It is unfortunate that many of these conditions, along with their deleterious effects, are poorly identified in pediatric settings despite the availability of screening instruments. Most screening instruments, however, assess for domain-specific areas of psychopathology only, and can require substantial time to administer and interpret within the …
Factors Related To Obsessive-Compulsive Symptoms: Understanding The Contribution Of Disgust, Contamination Fear And Emotion Regulation, Alexandra Gilbert
Factors Related To Obsessive-Compulsive Symptoms: Understanding The Contribution Of Disgust, Contamination Fear And Emotion Regulation, Alexandra Gilbert
Electronic Theses and Dissertations
The current study included 149 students from the University of Mississippi as apart of an archival dataset from a larger lab study. Results from the primary analyses indicate that all variables of interest (i.e. contamination fear, disgust sensitivity, and emotion regulation) were significantly correlated with OC symptoms. However, despite disgust’s associations with OC symptoms, results from regression analysis suggest that neither general disgust nor individual domains of disgust were predictive of contamination-based OC symptoms above and beyond contamination fear. Results from the hierarchical regression analysis emphasize the prominent role that contamination fear has on contamination-based OC symptoms. Further, sex differences …
The Effects Of Hypoxia And Freshwater Intrusion On The Eastern Oyster (Crassostrea Virginica), James Henry Gledhill
The Effects Of Hypoxia And Freshwater Intrusion On The Eastern Oyster (Crassostrea Virginica), James Henry Gledhill
Electronic Theses and Dissertations
Recent estimates revealed a significant decrease in oyster populations worldwide. This drastic decrease has detrimental effects on coastal and estuarine ecosystems. Two environmental stressors that are thought to be contributing to the oyster population decline are hypoxia and excess freshwater intrusion. In this study, effects of hypoxia and low salinity on oysters were investigated using a combination of laboratory and field-based methods. In the laboratory, oysters were exposed to 2, 4, or 8 days of hypoxia (< 2 mg/L dissolved oxygen) folloby 6 days of recovery in normoxic conditions. At the same time, caged oysters were exposed to a naturally occurring hypoxic event in the field. After 8 days, laboratory-exposed oysters shoevidence of immunosuppression indicated by significant downregulation of the immune-related gene thymosin-β4 (Tβ-4) and a significant decrease in total circulating hemocytes compared to controls. However, in field oysters exposed to a naturally occurring hypoxic event, no effect on total hemocyte counts and an upregulation of Tβ-4 was observed. In a second field study, to investigate how oysters respond to prolonged freshwater exposure, caged oysters were placed on 23 April 2019 at six reef sites in the Mississippi Sound along with in situ water quality sensors. One-hundred percent mortality of caged oysters occurred at four of the six sites. Of the 6 six sites, Henderson Point Reef and Kittiwake Reef shosome caged oyster survival. At Henderson Point, where higher mortality was observed compared to Kittiwake, a significant increase in lipid peroxidation was detected. Analysis of mRNA expression of surviving caged and native oysters revealed downregulation of genes involved in immune function, low oxygen response, and osmoregulation. These results show possible evidence of energetic depression which inhibits adequate adaptation to low salinity conditions. Energetic depression and increased oxidative damage could have contributed to higher oyster mortality. Dredge sampling of native oysters at the all Mississippi Sound field sites on 27 September 2019, following recovery to ~15 ppt salinity, still indicated 100% native oyster mortality due to the prior prolonged freshwater exposure. Continued monitoring of western Mississippi Sound oyster reefs is crucial to observe recovery of oyster populations.
A Study Of Contingent Faculty Representation In Governance At The University Of Mississippi, Mariana Rangel Allushuski
A Study Of Contingent Faculty Representation In Governance At The University Of Mississippi, Mariana Rangel Allushuski
Electronic Theses and Dissertations
Through interviews of members of the 2017-2018 Faculty Senate and of the Task Force, and in the chronological order in which events took place, the following topics were addressed: the role of contingent faculty on campus and in governance, contingent faculty experiences in their academic departments, major arguments for and against representation, Senators and Task Force members’ perspectives of the Task Force initial presentation to the Senate, and the successful outcome that followed. Through the discussion, this study addresses themes such as the role of the Faculty Senate, the future of contingent faculty in governance, the work that lies ahead, …
Unraveling Anticancer Activity And Pharmacokinetics Of Dihydroartemisinin Dimer Oxime, Lu Dai
Unraveling Anticancer Activity And Pharmacokinetics Of Dihydroartemisinin Dimer Oxime, Lu Dai
Electronic Theses and Dissertations
Artemisinin is currently used as an antimalaria drug. Studies have shown its monomeric form exhibited promising anticancer effects by inhibiting the proliferation, inducing apoptosis, and increasing oxidative stress of tumor cells. Recently, several dimeric forms of artemisinin have been synthesized with more potent anticancer activity. In this study, nine dihydroartemisinin dimers with diversely functionalized linkers exhibited similar cytotoxicity against human breast adenocarcinoma MDA-MB-231 in vitro. Among these nine DHA dimers, DHA dimer oxime was selected for further anticancer activity and pharmacokinetic study. Our preliminary study shothat DHA dimer oxime displayed more than a 10-fold increase of antiproliferation effect over its …
Behavioral Similarities And Differences Among Symptoms Of Emetophobia, Disordered Eating, And Disgust, Jennifer Arden Petell
Behavioral Similarities And Differences Among Symptoms Of Emetophobia, Disordered Eating, And Disgust, Jennifer Arden Petell
Electronic Theses and Dissertations
Emetophobia, also known as the specific phobia of vomiting (SPOV), is a clinical disorder with severe symptomatology and chronicity. However, there remains a significant lack of knowledge in overall conceptualization and etiological understanding. Recent literature has described this disorder within the context of abnormal eating disorders, despite the essential difference in symptom function between SPOV and disordered eating (Keyes & Veale, 2018; Volpe et al., 2015). Therefore, the present study sought to further the conceptualization and delineation of symptoms of emetophobia and disordered eating, as well as their potential relation with disgust. More specifically, it was hypothesized that symptoms of …
Civic Engagement Among Emerging Adults: Self-Efficacy, Purpose, And Program Experiences, Rachel Marsh
Civic Engagement Among Emerging Adults: Self-Efficacy, Purpose, And Program Experiences, Rachel Marsh
Electronic Theses and Dissertations
Understanding how to cultivate civic mindedness and engagement in emerging adults is of central importance. Theories of positive youth development point to the importance of particular youth characteristics for promoting the development of successful and contributing citizens (Lerner, Almerigi, Theokas, & Lerner, 2005). Among these, self-efficacy, or one’s belief in their ability to perform a specific task, is considered essential (Bandura, 1977; DeWitz, 2004; Solhaug, 2006). Scholars have, more recently, pointed to the role of purpose as key for motivating civic engagement (Damon, Menon, & Cotton Bronk, 2003). Beyond youth characteristics, other scholars point to the importance of opportunities for …
End Of Life Costs In Medicare Beneficiaries With Parkinson’S Disease, Sasikiran Nunna
End Of Life Costs In Medicare Beneficiaries With Parkinson’S Disease, Sasikiran Nunna
Electronic Theses and Dissertations
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder which is characterized by motor and non-motor disorders. The prevalence of PD is high among elderly patients. Due to the chronic nature of PD, increasing prevalence and ageing population, it is important to understand the burden of PD at various stages of patient’s life so that value of PD therapies can be assessed. While direct healthcare costs during the life time of PD were assessed in previous studies, there is lack of information about end of life costs in PD patients. This dissertation aimed at filling the gap in literature …
Characterization Of Drug-Loaded Milled Extrudate Particles Produced By Hot Melt Extrusion Technology For Dry Powder Inhalers, Ahmed Almotairy
Characterization Of Drug-Loaded Milled Extrudate Particles Produced By Hot Melt Extrusion Technology For Dry Powder Inhalers, Ahmed Almotairy
Electronic Theses and Dissertations
The aim of the current investigation is to develop a sustained-release dry powder inhalation (DPI) formulation through continuous Hot Melt Extrusion (HME) process and see the impact of Sodium Bicarbonate (SB) and Mannitol (MAN) on the hydrophobic Eudragit RL PO (ERLPO) polymer. Ball milling and air-jet milling were utilized to have powder with a particle size range that is required for inhalation. Air-jet milled formulations shopromising particle size results compared to ball milled formulations. All solid-state characterization studies revealed no change on Theophylline (TH) crystallinity or occurrence of drug-excipient interactions in physical mixtures and formulations. X2 formulation released TH constantly …
Collegiate Equity Mentoring Matrix: A Culturally Relevant Framework For The Meaningful Mentoring Of Black Male Students, Norris Allen Edney
Collegiate Equity Mentoring Matrix: A Culturally Relevant Framework For The Meaningful Mentoring Of Black Male Students, Norris Allen Edney
Electronic Theses and Dissertations
This dissertation reports on a qualitative analysis of the mentoring experiences of 22 successful Black males at the University of Mississippi. Several theories were used to frame the analysis. Bozeman and Feeney’s (2007) mentoring conceptualization helps to exact an operational definition for mentoring for the analysis. Theories describing the competition between the political interests which shape educational environments (Labaree, 1997) and student motivations to persist to graduation (Tinto, 2016) help to contextualize the barriers to success students encounter in college. Crisp and Cruz’s (2009) college mentoring theory helps to consider the potential for mentoring to support student success in college. …
Recall Reading Intervention For Children In Preschool And Kindergarten With Moderate To Severe Language Delays, Rebekah Christine Bosley
Recall Reading Intervention For Children In Preschool And Kindergarten With Moderate To Severe Language Delays, Rebekah Christine Bosley
Electronic Theses and Dissertations
Dialogic reading is a reading intervention method in which the adult prompts the child with questions and expansions. Previous research has documented that it has been effective in promoting engagement, increasing response rates, developing vocabulary knowledge, and increasing overall answer accuracy in children with Autism Spectrum Disorder (ASD) (Fleury, Miramontez, Hudson, & Schwartz, 2014; Fleury & Schwartz, 2016; Whalon, Martinez, Shannon, Butcher, & Hanline, 2015). The current study investigates whether children with moderate to severe language delays with or without Autism could increase their verbal and nonverbal responses and joint attention through the RECALL (Reading to Engage Children with Autism …
Vicar Victoria: Writing The Church Of England In Nineteenth-Century Fiction, Rachel Elizabeth Cason
Vicar Victoria: Writing The Church Of England In Nineteenth-Century Fiction, Rachel Elizabeth Cason
Electronic Theses and Dissertations
Vicar Victoria: Writing the Church of England in Nineteenth-Century Fiction shows how the organizing force of the Anglican Church and the figure of the Anglican clergyman were used to interrogate social, legal, and historical developments in nineteenth-century fiction. The project outlines how authors reacted to events such as Pluralism reform, the opening of training schools for clergy, and the Oxford Movement. There was a growing importance of institutions (including new physical buildings and Anglican reform movements). Further, the clergy, pushed by the increased expectation to modernize and professionalize, became a specialist career, with raised training and performance requirements. As a …
Disturbing The Ecological Pastoral: An Examination Of Willa Cather's Fictional Spaces In My Ántonia And Death Comes For The Archbishop, Anne Carter Stowe
Disturbing The Ecological Pastoral: An Examination Of Willa Cather's Fictional Spaces In My Ántonia And Death Comes For The Archbishop, Anne Carter Stowe
Electronic Theses and Dissertations
Willa Cather is universally lauded for her ability to render landscape into prose. Critics have observed for years that the landscape often functions as the main character in her fiction, or that her characters can easily be evaluated in terms of how deep and successful their relationships to the land are. In an attempt to evaluate Cather’s treatment of two different “Western” landscapes, I will focus first on My Ántonia, one of her most famous Nebraska novels, and second on Death Comes for the Archbishop, whose narrative unravels on the New Mexican landscape. I argue that Cather treats …
Damage Detection Using Destructive Testing Of A Reinforced Concrete Slab, Michael Edward Daves
Damage Detection Using Destructive Testing Of A Reinforced Concrete Slab, Michael Edward Daves
Electronic Theses and Dissertations
Visual inspection is one of the primary tools for evaluating the health of bridges as more reach or exceed their intended lifespan. Bridge deterioration must be monitored to ensure continued safety, so owners need maintenance reports to decide on corrective actions. Strategic repair can offer asset managers the benefit of saving money and time; thus, knowing where to locate and what type of repairs can be challenging when relying on visual techniques alone. A tool designed to aid bridge inspectors is the SHE^tm program, which quantitatively measures damage location and severity for any set of time data.
Do Individual Responses To Resistance Exercise Exist To An Extent That Can Be Detected Beyond That Of Measurement Error/Random Biological Variability?, Scott J. Dankel
Do Individual Responses To Resistance Exercise Exist To An Extent That Can Be Detected Beyond That Of Measurement Error/Random Biological Variability?, Scott J. Dankel
Electronic Theses and Dissertations
Millions of dollars are spent analyzing inter-individual differences in response to resistance exercise, but the lack of a non-exercise control group means they may simply be examining random error. The purpose of this study was to determine whether there are inter-individual differences in response to two distinct resistance exercise protocols. Participants (n=151) were randomly assigned to one of 3 groups as follows: (1) a traditional exercise group performing 4 sets to failure with a load that could be lifted 8-12 times; (2) a one-repetition maximum (1RM) training group performing a 1RM test each visit; and (3) a non-exercise control group. …
Progress Toward The Synthesis Of 3-Methoxyflavones As Potential Antioxidants, Neuroprotective Agents, And Trifluoromethylated 19f Nmr Probes, Reem Alkhodier
Progress Toward The Synthesis Of 3-Methoxyflavones As Potential Antioxidants, Neuroprotective Agents, And Trifluoromethylated 19f Nmr Probes, Reem Alkhodier
Electronic Theses and Dissertations
The total synthesis of polyhydroxylated flavones have proven to be challenging, due to the presence of more than one hydroxyl group. Direct cyclization was not successful in any of the attempts. However, by using a silyl protecting group, the cyclization was feasible. Other reactions like the Friedel-Crafts acylation and selective protection of phenols were also difficult.
Synthesis Of Fluoroflavones As Potential Neuroprotective Agents, Maali Alshammari
Synthesis Of Fluoroflavones As Potential Neuroprotective Agents, Maali Alshammari
Electronic Theses and Dissertations
Flavones are polyphenol natural products that are known to have neuroprotective effects against many diseases caused by the formation of reactive species. Flavonoids are subgroup of flavones and they are believed to function as antioxidants. Specifically, they target free radicals and eliminate its harmful effect on the cell. Fluoroflavones were designed to improve the potency of the antioxidant activity and potentially be used as neuroprotective agents. A monofluorinated and trifluoromethylated flavone were synthesized by using commercially available fluorination reagents, N-fluorobenzenesulfonimide; and Togni’s or Umemoto's respectively. After the synthesis of the desired flavones and their monofluorinated and trifluoromethylated derivatives, biological testing …
Design Of Thermosensitive Hydrogel For Extended-Release Of Praziquantel, Sheng Feng
Design Of Thermosensitive Hydrogel For Extended-Release Of Praziquantel, Sheng Feng
Electronic Theses and Dissertations
Parasitic diseases are a severe threat to people and animals. Praziquantel is the most comanti-parasitic drug with high efficiency, and it has been used to treat parasitic diseases for many years. However, it has very strong gastrointestinal and liver metabolism that leads to a strong first-pass effect and a short half-life. Additionally, the frequent oral administration was inconvenient for the large livestock. To overcome these drawbacks, this study aimed to develop an extended-release thermosensitive hydrogel formulation that was applicable to the injectable administration. The praziquantel-loaded hydrogel formulation based on poloxamer 407 (20%, w/v) was prepared, and two strategies for modifications …
Balancing Reading Motivation: A Comparative Case Study Of High School Students And Their Teachers, Pasteia Garth
Balancing Reading Motivation: A Comparative Case Study Of High School Students And Their Teachers, Pasteia Garth
Electronic Theses and Dissertations
The purpose of this study is to understand how teachers successfully balance instruction in a high stakes tested classroom environment to promote reading motivation.. To analyze, the researcher focused on two tenth grade English classroom, two tenth grade English teachers, and eight tenth grade students who are identified as proficient readers. One teacher has 19 years of teaching experience with only one of those years being a high school English teacher. The other teacher has 12 years of teaching experience of teaching high school, and this is her eighth year teaching 10th grade.
Community Resilience: A Meta-Study Of International Development Rhetoric In Emerging Economies, Rachel Ann Haggard
Community Resilience: A Meta-Study Of International Development Rhetoric In Emerging Economies, Rachel Ann Haggard
Electronic Theses and Dissertations
Understood generally, community resilience is the ability of communities to adapt, absorb, mitigate, and recover from shocks and stressors in such a way that facilitates positive future outcomes and reduces overall vulnerability to future shocks and stressors (Adger, 2000; Norris, Stevens, Pfefferbaum, Wyche & Pfefferbaum, 2008; USAID, 2013; Walker et al., 2004). The core of this definition relates to sustainability and the capability of socio-ecological systems and communities to adapt and transform to both day to day fluctuations and stressors as well as major disasters (Milman & Short, 2008; Walker et al., 2004). This meta-study seeks to shed light on …
Students’ Perceptions And Strategies For Success In An Associate Degree Nursing Program, Theresa Hargett
Students’ Perceptions And Strategies For Success In An Associate Degree Nursing Program, Theresa Hargett
Electronic Theses and Dissertations
The three-manuscript dissertation is based on perceptions and personal strategies of successful third-semester nursing students about retention interventions at Holmes Community College Associate Degree Nursing Program on the Grenada Campus. Retention and attrition of nursing students is a current area of concern at Holmes Community College in the Associate Degree Nursing Program. Understanding adaptations that led third-semester students in the ADN program to be successful in their first-year is the focus of this study. The research questions seek to answer second-year, third-semester students’ perceptions of their first-year experiences of faculty interventions and personal strategies applied for success. Understanding adaptations and …
The Politics Of Place, The Urban-Rural Divide, And Geographic Identities In American Politics, Daniel Fudge
The Politics Of Place, The Urban-Rural Divide, And Geographic Identities In American Politics, Daniel Fudge
Electronic Theses and Dissertations
To test these theories, I conduct a series of empirical tests using survey data from the American National Election Survey (ANES) and an original survey experiment. Chapter two examines how people’s ideological perceptions are moderated by living in a particular area. Using the ANES data, I conduct a regression analysis with an interaction of the respondent’s ideology and the geographic location. Chapter three analyzes how individuals perceive a political candidate based on partisan and geographic information presented to the respondent. Using an original survey experiment, this study seeks to illustrate how individuals across urban and rural America perceive Republican and …
What’S Going On? The Disproportionate Discipline Of Upper Elementary Male Students In Little Tiger Elementary School, Amy Katrise Sutton
What’S Going On? The Disproportionate Discipline Of Upper Elementary Male Students In Little Tiger Elementary School, Amy Katrise Sutton
Electronic Theses and Dissertations
This action research study investigates the problem of disproportionate male discipline at LTES, specifically through the implementation of the PBIS program. Both quantitative and qualitative data provide a thorough explanation of student misbehaviors and discipline reporting practices at LTES. Through the utilization of teacher surveys, interviews, descriptive statistics, and anecdotal notes, the researcher presents findings which provide hope for improving male student behavior and discipline reporting practices. The study focuses on answering the overarching question, did the action plan result in a 20% decrease of male student discipline referrals within the first year of implementation? To answer this question a …
Pharmacokinetic Study Of Novel Anthraquinone Analogues, Yuhan Guo
Pharmacokinetic Study Of Novel Anthraquinone Analogues, Yuhan Guo
Electronic Theses and Dissertations
Small molecules functioning as negative regulators of MDM2 have been considered as promising anti-cancer agents. A series of novel anthraquinone (AQ) analogues upregulate p53, a well-known tumor suppressor, by inactivating its antagonist protein MDM2. The novel AQ compounds synthesized through the modifications on the rhein scaffold were reported to have successfully arrested tumor growth. To have a better understanding of their underlying metabolism in vivo, pharmacokinetic (PK) studies were performed for the AQ compounds. A selective, accurate and reproducible assay methodology for PK study was set up for each AQ compound. The stabilities of AQ compounds were then evaluated …
Development Of Controlled Release Oral Dosages By Density Gradient Modification Using 3d Printing Technologies, Zhiqing Hu
Electronic Theses and Dissertations
Over the years, three-dimensional (3D) printing has gradually become more comin people's lives. Due to its quick development, it has attracted the attention of researchers in the pharmaceutical industry. The main purpose of this project was to couple fused deposition modelling (FDM) 3D printing with hot melt extrusion (HME) technology to manufacture tablets with different drug release profiles and to solve dose issues related to an individual’s physiological differences and to enhance extended release properties. Ketoprofen was used as the model drug and different properties were added to the polymer to create a formulation suited to HME technology for the …
Expression Of Tumor Necrosis Factor-Alpha In A Chick Model Of Stress Vulnerable, Treatment – Resistant Depression, Mary Katherine Jourdan
Expression Of Tumor Necrosis Factor-Alpha In A Chick Model Of Stress Vulnerable, Treatment – Resistant Depression, Mary Katherine Jourdan
Electronic Theses and Dissertations
An increasing body of literature suggests a Major Depressive Disorder subpopulation, Treatment Resistant Depression (TRD), is associated with an increased immune response. More than a decade of research has identified and begun to validate a novel animal model of TRD. This study sought to determine whether TNF-α levels would be altered due to isolation stress and differentiated between stress-vulnerable and -resilient strains. Black Australorp and Production Red chicks were placed into isolation for varying times during which Distress Vocalization (dVoc) rates were calculated and transformed into entry into behavioral despair percent thresholds. Blood levels of TNF- α were quantified via …