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Relationship Between Tdp-43 Toxicity And Aggregation In Saccharomyces Cerevisiae, Martin Anthony Aguilar Jan 2018

Relationship Between Tdp-43 Toxicity And Aggregation In Saccharomyces Cerevisiae, Martin Anthony Aguilar

Electronic Theses and Dissertations

Protein aggregation and inclusion body formation are hallmarks of neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS). These neurodegenerative diseases share a common pathology in that all include accumulation of insoluble protein aggregates in the brain. TAR-DNA-binding protein (TDP-43) is the major component found in the pathological inclusions of two of these diseases, ALS and frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). This thesis focuses upon the biophysical basis for TDP-43 aggregation in S. cerevisiae. Current in vitro evidence indicates that TDP-43 is a natively dimeric protein and that binding to RNA inhibits aggregation. Corresponding …

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Living Through Terror And Terror Through Living: The Biopolitical Dimensions Of Religion, Security, And Terrorism, Donnie Featherston Jan 2018

Living Through Terror And Terror Through Living: The Biopolitical Dimensions Of Religion, Security, And Terrorism, Donnie Featherston

Electronic Theses and Dissertations

Recent emphasis and attention by thinkers, media pundits, and politicians on terrorism requires new, critical evaluation of the processes by which terrorism is understood. By investigating the concept of biopolitics, as developed specifically through Michel Foucault and Giorgio Agamben, new insights into the interactions between terrorism, politics, and religion can emerge. Most notably, the attempts to explain terror as simply an economic problem, an excessive form of violence, and/or as religious fervency gone awry rely on embedded biopolitical concepts. The continual attempts to solve terrorism through increased biopolitical strategies, thereby making terrorism a problem for biopolitics, only further substantiate the …

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The Investigation Of Lactoferrin Nitration: Quantification, Function, And Inhibition, Amani Yahya Alhalwani Jan 2018

The Investigation Of Lactoferrin Nitration: Quantification, Function, And Inhibition, Amani Yahya Alhalwani

Electronic Theses and Dissertations

Lactoferrin (LF) is an iron-binding glycoprotein of molecular mass ca. 80 kDa that is predominantly found in mammalian body fluids. Lactoferrin is a multifunctional protein that has a wide range of properties such as antibacterial, antiviral, anti-inflammatory, and anti-allergic functions. Tyrosine residues in the protein play a part in many lactoferrin functions. Protein tyrosine nitration modification represents an oxidative and nitrosative stress process which can be caused by the exposure of proteins to oxidants from air pollution or disease. Understanding the way nitrated lactoferrin interacts with the biochemical environment of the body is thus important to the broader goal of …

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Categorical Change: Exploring The Effects Of Concept Drift In Human Perceptual Category Learning, Andrew Wismer Jan 2018

Categorical Change: Exploring The Effects Of Concept Drift In Human Perceptual Category Learning, Andrew Wismer

Electronic Theses and Dissertations

Categorization is an essential survival skill that we engage in daily. A multitude of behavioral and neuropsychological evidence support the existence of multiple learning systems involved in category learning. COmpetition between Verbal and Implicit Systems (COVIS) theory provides a neuropsychological basis for the existence of an explicit and implicit learning system involved in the learning of category rules. COVIS provides a convincing account of asymptotic performance in human category learning. However, COVIS – and virtually all current theories of category learning – focus solely on categories and decision environments that remain stationary over time. However, our environment is dynamic, and …

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Unearthing The Past And Present Of A Semi-Fossorial Lizard: Conservation Genetics, Phylogeography, And Taxonomy Of Plestiodon Egregius., Kathryn Mercier Jan 2018

Unearthing The Past And Present Of A Semi-Fossorial Lizard: Conservation Genetics, Phylogeography, And Taxonomy Of Plestiodon Egregius., Kathryn Mercier

Electronic Theses and Dissertations

Characterizing an organism's evolutionary history and population structure as well as understanding the forces shaping that divergence is crucial to conservation biology. A clear understanding of the patterns of diversity and divergence are imperative for the best management of the organism, while an awareness of what drives these patterns can lead to better predictions of how organisms will respond to future climate change. Historical climate changes and associated sea level change are among the main forces driving divergence in many species. To examine how effects of climate changes may have driven patterns of intraspecific divergence, I examined Mole Skinks, Plestiodon …

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Emergent Narrative: Stories Of Play, Playing With Stories, Eric Murnane Jan 2018

Emergent Narrative: Stories Of Play, Playing With Stories, Eric Murnane

Electronic Theses and Dissertations

Emergent narrative, a phenomenon of unexpected contextual stories arising through play, has been researched in the field of game studies since 1999. However, that discussion largely lies in the realm of theoretical stories which are generated by either the system or the player. The purpose of this dissertation is to deepen our understanding of emergent narrative by examining real-world examples of the phenomenon. Four hundred player posts were gathered from forums relating to the video game Skyrim (a large, open world fantasy roleplaying game) and analyzed using a mixed-method framework which is informed by digital ethnography, fan studies, and game …

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Visionary Ophthalmics: Confluence Of Computer Vision And Deep Learning For Ophthalmology, Dustin Morley Jan 2018

Visionary Ophthalmics: Confluence Of Computer Vision And Deep Learning For Ophthalmology, Dustin Morley

Electronic Theses and Dissertations

Ophthalmology is a medical field ripe with opportunities for meaningful application of computer vision algorithms. The field utilizes data from multiple disparate imaging techniques, ranging from conventional cameras to tomography, comprising a diverse set of computer vision challenges. Computer vision has a rich history of techniques that can adequately meet many of these challenges. However, the field has undergone something of a revolution in recent times as deep learning techniques have sprung into the forefront following advances in GPU hardware. This development raises important questions regarding how to best leverage insights from both modern deep learning approaches and more classical …

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Olfaction, Memory, And Presence In Warfighters: Do The Scents Of War Matter?, Benson Munyan Jan 2018

Olfaction, Memory, And Presence In Warfighters: Do The Scents Of War Matter?, Benson Munyan

Electronic Theses and Dissertations

Background: Exposure therapy (EXP) is a first-line intervention for combat-related PTSD. EXP works by repeatedly exposing the patient to the feared stimuli, situation, or physical sensations in the absence of actual danger until the stimuli no longer evoke maladaptive responses. Over the past decade, multiple technologies have been introduced to augment the EXP process by presenting multi-sensory cues (e.g., sights, smells, sounds) to increase patients' sense of presence. Exploratory research has only broadly examined the effect of odorants on the patient's sense of presence during simulated exposure tasks. This study hypothesized that those with autobiographical memories similar to the virtual …

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Harmful Algal Bloom Mitigating Using Recycled Concrete Aggregate Coated With Fixed-Quat., Ikenna Ezeodurukwe Jan 2018

Harmful Algal Bloom Mitigating Using Recycled Concrete Aggregate Coated With Fixed-Quat., Ikenna Ezeodurukwe

Electronic Theses and Dissertations

Human activities generate surplus nutrients which may lead to algal bloom events in water resources along with serious ecological problems and thus substantial economic losses. Particularly, harmful algal blooms (HABs) represent toxic cyanobacterial blooms which produce cyanotoxins. The primary concerns of HABs are the exposures to a wide variety of cyanotoxins via ingestion of contaminated drinking water, inhalation during recreational activities, and consumption of contaminated fish and shellfish. However, conventional physical and chemical methods are not always possible to efficiently handle these HABs events. It is urgent to develop viable and rapid solutions to control HABs in field and mitigate …

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Human Factor Effects Of Simulating Battlefield Malodors In Field Training, William Pike Jan 2018

Human Factor Effects Of Simulating Battlefield Malodors In Field Training, William Pike

Electronic Theses and Dissertations

In order to explore how to better utilize simulated odors for live training, a study of 180 United States Military Academy at West Point cadets was undertaken to determine whether pre-exposure to a simulated malodor may result in an amelioration of performance issues, as well as improving performance of a complex task. Exposure to malodors has long been shown to increase stress and escape behavior, and reduce performance of complex tasks, in addition to degrading other human factor areas. However, desensitization to a particular odor through a process known as olfactory adaptation, could ameliorate these performance issues. In this study, …

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A Review And Selective Analysis Of 3d Display Technologies For Anatomical Education, Matthew Hackett Jan 2018

A Review And Selective Analysis Of 3d Display Technologies For Anatomical Education, Matthew Hackett

Electronic Theses and Dissertations

The study of anatomy is complex and difficult for students in both graduate and undergraduate education. Researchers have attempted to improve anatomical education with the inclusion of three-dimensional visualization, with the prevailing finding that 3D is beneficial to students. However, there is limited research on the relative efficacy of different 3D modalities, including monoscopic, stereoscopic, and autostereoscopic displays. This study analyzes educational performance, confidence, cognitive load, visual-spatial ability, and technology acceptance in participants using autostereoscopic 3D visualization (holograms), monoscopic 3D visualization (3DPDFs), and a control visualization (2D printed images). Participants were randomized into three treatment groups: holograms (n=60), 3DPDFs (n=60), …

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A Holistic Analysis Of The Long-Term Challenges & Potential Benefits Of The Green Roof, Solar Pv Roofing, And Gripv Roofing Markets In Orlando, Florida, Carolina Kelly Jan 2018

A Holistic Analysis Of The Long-Term Challenges & Potential Benefits Of The Green Roof, Solar Pv Roofing, And Gripv Roofing Markets In Orlando, Florida, Carolina Kelly

Electronic Theses and Dissertations

Green roofs and roof-mounted solar PV arrays have a wide range of environmental and economic benefits, including significantly longer roof lifetimes, reductions in urban runoff, mitigation of the urban heat island (UHI) effect, reduced electricity demand and energy dependence, and/or reduced emissions of greenhouse gases (GHGs) and other harmful pollutants from the electricity generation sector. Consequently, green roofs and solar panels have both become increasingly popular worldwide, and promising new research has emerged for their potential combination in Green Roof Integrated Photovoltaic (GRIPV) roofing applications. However, due to policy resistance, these alternatives still have marginal market shares in the U.S., …

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Simultaneous Use Of Physiological Sensors For A Neuromarketing Task, Charles Descheneaux Jan 2018

Simultaneous Use Of Physiological Sensors For A Neuromarketing Task, Charles Descheneaux

Electronic Theses and Dissertations

Physiological measurements have become more popular in Psychological research over the past ten years. These advancements allowed different objective sensors to become another measurement tool in a scientific arsenal of collecting data. Traditionally, performance and after task subjective measures have been used for most studies in Psychological research. With the opportunity to use these subjective measures along with objective measures, more data can be collected during research and therefore potentially produce better quality conclusions. Eye Tracking (ET), functional near infrared (fNIR), transcranial Doppler ultrasound (TCD), electrocardiogram (EKG) and the electroencephalogram (EEG) have shown great promise in their ability to produce …

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Simulating Human Pleura Performance In Medical Training Using Measured Tissue Mechanical Properties, Jack Norfleet Jan 2018

Simulating Human Pleura Performance In Medical Training Using Measured Tissue Mechanical Properties, Jack Norfleet

Electronic Theses and Dissertations

Medical simulations provide hands-on training at various levels of medical expertise. Yet these simulators fail to accurately mimic the look, feel and behavior of human tissue. Applying measured mechanical properties from human cadaver tissues promises to improve the fidelity of simulated tissue behaviors when subjected to medical procedures. Samples of human parietal pleura were tested under uniaxial tension to failure and measured characteristics were replicated in synthetic pleura. Context specific parameters were then collected and compared between human pleura and the new synthetics. These comparisons tested the hypothesis; H1 Gaps exist between synthetic and human pleura performance, H2: Human tissue …

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Development Of Soil Compressibility Prediction Models, Scott Kirts Jan 2018

Development Of Soil Compressibility Prediction Models, Scott Kirts

Electronic Theses and Dissertations

The magnitude of the overall settlement depends on several variables such as the Compression Index, Cc, and Recompression Index, Cr, which are determined by a consolidation test; however, the test is time consuming and labor intensive. Correlations have been developed to approximate these compressibility indexes. In this study, a data driven approach has been employed in order to estimate Cc and Cr. Support Vector Machines classification is used to determine the number of distinct models to be developed. The statistical models are built through a forward selection stepwise regression procedure. Ten variables were used, including the moisture content (w), initial …

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E.A.I. Anxiety: Technopanic And Post-Human Potential, Zachary Mandell Jan 2018

E.A.I. Anxiety: Technopanic And Post-Human Potential, Zachary Mandell

Electronic Theses and Dissertations

Robots have been a part of the imagination of Western culture for centuries. The possibility for automation and artificial life has inspired the curiosity of thinkers like Leonardo Da Vinci who once designed a mechanical knight. It wasn't until the 19th century that automated machinery has become realized. The confrontation between human and automation has inspired a fear, referred to as "technopanic", that has been exacerbated in tandem with the evolution of technology. This thesis seeks to discover the historical precedence for these fears. I explore three modes of knowledge (Philosophy, Economics, and Film Theory) to examine the agendas behind …

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Exploring A Three-Dimensional Narrative Medium: The Theme Park As "De Sprookjessprokkelaar," The Gatherer And Teller Of Stories, Carissa Baker Jan 2018

Exploring A Three-Dimensional Narrative Medium: The Theme Park As "De Sprookjessprokkelaar," The Gatherer And Teller Of Stories, Carissa Baker

Electronic Theses and Dissertations

This dissertation examines the pervasiveness of storytelling in theme parks and establishes the theme park as a distinct narrative medium. It traces the characteristics of theme park storytelling, how it has changed over time, and what makes the medium unique. This was accomplished using a mixed methods approach drawing data from interviews with creative professionals, archival research, fieldwork, and an analysis of more than eight hundred narrative attractions. The survey of narrative attractions revealed the most common narrative expressions to be dark rides and stage shows. Source material tends to be cultural tales (legends, fairy tales) or intellectual properties (generally …

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The American Black Body: Materials,Symbols, And Representations From A Perceived African American, Christopher Santos Jan 2018

The American Black Body: Materials,Symbols, And Representations From A Perceived African American, Christopher Santos

Electronic Theses and Dissertations

As a Cape Verdean American, I investigate the idea of what it means to be of the African Diaspora in America. I also consider the experiences of past generations of American black bodies and how their history has molded my world. This series of work began with Mask Drawing 1, an ink drawing inspired by my own interpretation of an African mask. Subjected to colorism, the discrimination of a person based on their skin color, my skin was not enough validation for other people to view me as black. On numerous occasions I have had to clarify my identity, nationality …

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Momentum, Moment, Epiphany: The Psychological Intersection Of Motion Picture, The Still Frame, And Three-Dimensional Form, Mark Gerstein Jan 2018

Momentum, Moment, Epiphany: The Psychological Intersection Of Motion Picture, The Still Frame, And Three-Dimensional Form, Mark Gerstein

Electronic Theses and Dissertations

My journey from Hollywood Film production to a Fine Arts practice has been shaped by theory from Philosophy of Mind, Cognitive Psychology, Film, and Art, leading me to a new visual vocabulary at the intersection of motion picture, the still image, and three-dimensional form. I create large mixed media collages by projecting video onto photographs and sculptural forms, breaking the boundaries of the conventional film frame and exceeding the dynamic range of typical visual experience. My work explores emotional connections and fissures within family, and hidden meanings of haunting memories and familiar places. I am searching for an elusive type …

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To The Memory Of Brave Men: The Imperial War Graves Commission And India's Missing Soldiers Of The First World War, Roger Sims Jan 2018

To The Memory Of Brave Men: The Imperial War Graves Commission And India's Missing Soldiers Of The First World War, Roger Sims

Electronic Theses and Dissertations

This thesis examines the commemoration of Indian soldiers who died during the First World War by the Imperial War Graves Commission, Britain's official government body overseeing all imperial commemoration efforts. For the soldiers of the Indian Army their war experience was split between the Western Front in Europe and Mesopotamia in modern-day Iraq. They were also far more ethnically, religiously, and lingually diverse than their British and Dominion counterparts. In order to examine how geography, religion, and the imperial relationship affected Britain's commemoration of India's war dead, this study uses the Commission's own records to recreate how the IWGC created …

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Revisiting Roadside Attractions: A "Deep Dive" Into Florida's Weeki Wachee Springs, Rebecca Schwandt Jan 2018

Revisiting Roadside Attractions: A "Deep Dive" Into Florida's Weeki Wachee Springs, Rebecca Schwandt

Electronic Theses and Dissertations

This digital public history project explores one of the oldest and longest running of Florida's roadside attractions, Weeki Wachee Springs, during the years considered to be the park's heyday, the 1950s through the mid-1970s. With the 75th anniversary of the park approaching in 2022 and preliminary discussions of a new or expanded mermaid museum, there is a growing need to document the experiences of aging former employees and preserve park-related ephemera from that period. For this project six oral histories of former mermaids and former employees have been recorded, transcribed, and made publicly accessible through RICHES, the University of Central …

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Influence Of Selected Factors On A Counselor's Attention Level To And Counseling Performance With A Virtual Human In A Virtual Counseling Session, John Hart Jan 2018

Influence Of Selected Factors On A Counselor's Attention Level To And Counseling Performance With A Virtual Human In A Virtual Counseling Session, John Hart

Electronic Theses and Dissertations

Virtual humans serve as role-players in social skills training environments simulating situational face-to-face conversations. Previous research indicates that virtual humans in instructional roles can increase a learner's engagement and motivation towards the training. Left unaddressed is if the learner is looking at the virtual human as one would in a human-to-human, face-to-face interaction. Using a modified version of the Emergent Leader Immersive Training Environment (ELITE-Lite), this study tracks visual attention and other behavior of 120 counselor trainees counseling a virtual human role-playing counselee. Specific study elements include: (1) the counselor's level of visual attention toward the virtual counselee; (2) how …

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Usda Instructional Risk Messages For High Pathogen Avian Influenza, Jenna Jones Jan 2018

Usda Instructional Risk Messages For High Pathogen Avian Influenza, Jenna Jones

Electronic Theses and Dissertations

High Pathogen Avian Influenza (HPAI) is a highly contagious disease threatening United States poultry farms. The aim of this study is to examine the extent to which current instructional risk communication by the United States Department of Agriculture (USDA) meets the expectations of existing literature, particularly the IDEA model. This study examined two documents produced by the USDA for the ongoing threat of HPAI, the Red Book and the Defend the Flock campaign. The aim of the documents is to provide U.S. poultry farmers and the publics with knowledge and information about prevention and response to HPAI. The IDEA model …

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Effects Of Large-Scale Density Reduction On Brown Trout Growth And Movement In Spearfish Creek, South Dakota, Travis Rehm Jan 2018

Effects Of Large-Scale Density Reduction On Brown Trout Growth And Movement In Spearfish Creek, South Dakota, Travis Rehm

Electronic Theses and Dissertations

Density-dependent growth is often observed in stream-dwelling Brown Trout Salmo trutta populations. In Spearfish Creek, South Dakota, biomass of adult Brown Trout (>200 mm) is about three times greater than that reported for similar Black Hills streams while mean length of adult fish is about 30% less. Here, we evaluate large-scale density reduction as a management tool for improving growth rate of stream-dwelling Brown Trout. We compared age-specific growth of wild Brown Trout in stream sections receiving 50% reductions in fish abundance. We also assessed the effect of fish density manipulation on Brown Trout movement patterns and home range …

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The Influence Of Spore-Forming Microorganisms On The Quality And Functionality Of Cultured Dairy Products, Dipakkumar Mehta Jan 2018

The Influence Of Spore-Forming Microorganisms On The Quality And Functionality Of Cultured Dairy Products, Dipakkumar Mehta

Electronic Theses and Dissertations

Spore formers are observed as the common spoilage-causing microflora in milk and dairy products. Their spore-forming ability increases their survivability during heat treatment which leads to their presence in a final product. Spore-forming bacteria have ability to produce many types of spoilage-causing enzymes which are potential to influence quality and functionality of the final product. Many researchers have studied the ability of spore formers to induce a spoilage in various dairy products but as per our knowledge, their spoilage-causing activities are not described in a detail for cultured dairy products. In our first objective, we have studied the ability of …

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Understanding City Parks As New Common Pool Resources: A Case Study Of The Dakota Nature Park, Keahna Margeson Jan 2018

Understanding City Parks As New Common Pool Resources: A Case Study Of The Dakota Nature Park, Keahna Margeson

Electronic Theses and Dissertations

This thesis examines public parks as New Common Pool Resources through a case study of the Dakota Nature Park in Brookings, South Dakota. I identify the formalization and bureaucratization processes experienced by the governing body of the park. These processes occurred as a capped landfill was repurposed and collaboratively managed to serve the community by providing native, natural space and affordable recreational opportunities. The governing structure is assessed using Elinor Ostrom’s (1990) Eight Principles of Common Pool Resource Management, Weber’s (1964) ideas of status and authority and Berger and Luckman's (1966) phenomenological theory. I use three major research strategies: (1) …

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Comparison Of Retaining Replacement Heifers In A Straight-Bred Angus System Versus Purchasing Crossbred Replacement Heifers To Be Bred To A Terminal Sire, Grady D. Ruble Jan 2018

Comparison Of Retaining Replacement Heifers In A Straight-Bred Angus System Versus Purchasing Crossbred Replacement Heifers To Be Bred To A Terminal Sire, Grady D. Ruble

Electronic Theses and Dissertations

Two evaluations were conducted to evaluate the biological and economic production efficiency of retaining replacement females in a straight-bred Angus herd (HR) as opposed to purchasing crossbred replacements for a terminal sire production system (PR) where maximum maternal and individual heterosis is achieved. The first study was a comparison of the HR system versus PR system. It was modeled after a 100 hd, straightbred Angus cowherd that raises their own replacement females. The (NASEM, 2016) model was used to determine the required metabolizable energy (ME)/animal for each stage of production. Stages were broken into segments including weaning – d 28, …

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Diversity Of Free – Living Nitrogen – Fixing Bacteria In Soil Of Sioux Prairie Of South Dakota, Nabilah Ali Alshibli Jan 2018

Diversity Of Free – Living Nitrogen – Fixing Bacteria In Soil Of Sioux Prairie Of South Dakota, Nabilah Ali Alshibli

Electronic Theses and Dissertations

There are only two natural ways by which molecular nitrogen can be available to support life, either by free-living or by symbiotic nitrogen fixing bacteria. The best studied diazotrophs form symbiotic associations with plants, primarily legumes and certain tree species, but little is known about how non-leguminous plants such as grasses obtain nitrogen in their environment. Natural prairies have few legumes, thus have less symbiotic nitrogen fixer interaction. This indicates presence of free-living nitrogen (FLN) fixation activity towards the balance of the N cycle. The objective of this study was to characterize the culturable diversity of free-living diazotrophs in native …

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Can Solvent-Or Mechanically-Extracted Carinata Meal Be Used As An Effective Source Of Supplemental Protein To Cows Fed Poor Quality Forages?, Emily Jacklyn Rosenthal Jan 2018

Can Solvent-Or Mechanically-Extracted Carinata Meal Be Used As An Effective Source Of Supplemental Protein To Cows Fed Poor Quality Forages?, Emily Jacklyn Rosenthal

Electronic Theses and Dissertations

Brassica carinata is an oilseed crop that requires a relatively short growing season and produces high crop yields. It is a great source for aviation biofuel, however it produces a large amount of waste that may be used as a protein supplement for cattle. We tested the effects of solvent- or mechanically-extracted carinata meal as a protein supplement to ad libitum ground or long-stem corn residue (i.e., corn plant left over from grain harvest) had on cow performance and digestibility. Fifty-six non-pregnant cows in 8 pens had ad libitum access to either long-stem or ground corn residue in addition to …

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Strategies To Improve Calf Performance: Improving Water Quality, Feeding Microbially-Enhanced Soy Protein, And Supplementing Condensed Whey Solubles, Nirosh Dias Senevirathne Jan 2018

Strategies To Improve Calf Performance: Improving Water Quality, Feeding Microbially-Enhanced Soy Protein, And Supplementing Condensed Whey Solubles, Nirosh Dias Senevirathne

Electronic Theses and Dissertations

Six experiments were conducted for this dissertation research to evaluate strategies to improve growth performance and health of calves. Growth performance, nutrient utilization, and health effects were evaluated when calves were offered water treated with reverse osmosis system (RW), fed starter pellets supplemented with microbially-enhanced soy protein (MSP) or supplemented condensed whey solubles (CWS). The first two experiments were conducted to determine drinking preference, growth performance, and health of dairy calves offered RW or by a municipal water treatment plant (MW), compared with local untreated well water (WW). First a sequential elimination study was conducted to observed drinking preference of …

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