Digital Commons Network^™

Generation Of Full-Length Wild-Type Gata4 Protein And Characterization Of Its Binding To Unc-45 Domains, Morgan Anderson

Electronic Theses and Dissertations

Striated muscle UNC-45 (SM UNC-45) protein acts as a chaperone for cardiac and skeletal muscle myosins; regulating their folding, assembly into thick filaments, interaction with other sarcomeric proteins, and degradation. GATA4 is an important transcription factor that regulates the expression of several cardiac muscle proteins, including myosin. A previous study demonstrated for the first time that SM UNC-45 (also known as UNC-45B) physically interacted with GATA4. The major revelation from this study is that SM UNC-45 has the potential to exert both short-term (protein level) and long-term (gene level) controls over myosin and therefore muscle structure and function. The aim …

Academic Consequences Of Legal Handgun Carrying On College Campuses, Hayden Holmes

Electronic Theses and Dissertations

Many states have discussed allowing concealed handguns on college campuses, known colloquially as campus carry. It is crucial to gauge whether allowing campus carry affects more than just crime rates. Previous research indicated overwhelmingly negative attitudes towards allowing campus carry. The purpose of the current study was to determine whether knowledge of someone carrying a concealed handgun in class would affect students’ ability to perform well on an exam. Across two studies, evidence and theoretical rationale suggested that knowledge of someone carrying a concealed handgun in class negatively impacted learning, although non-significantly. Individuals who were told that others (i.e., the …

Ptolemaic Elephants In Iii Maccabees And The Social Stratification Of The Kingdom Of Kush, Leslie Dean Sam Jr.

Electronic Theses and Dissertations

Trade helped to catapult early societies from hunter gatherers – living in small communities of friends and family – to living in sprawling urban environments of ideas and exchange. Socialization and the exchange of ideas – and war—molded our modern times into what it is now. Ancient Nubia found itself in a conundrum that would test their resolve. Ptolemaic-ran Egypt was at their border, forcing themselves in as conquerors, unapologetic towards the millennia old culture that contributed much to their society. With a truce made between the Greeks and Meroe, trade was inevitably was enacted between the two power houses, …

A Meta-Analytic Review Of Cognitive Functioning In Negative And Positive Symptoms Of Schizophrenia, Tiffany Forsythe

Electronic Theses and Dissertations

The purpose of the study was to conduct two meta-analytic reviews examining cognitive functioning and schizophrenia. The first review examined the literature comparing the cognitive functioning of schizophrenic patients to healthy controls. A second review examined the cognitive functioning within schizophrenic patients, examining the differences between individuals with primarily positive symptomatology and those with primarily negative symptomatology. The first meta-analysis included 19 studies which assessed 861 schizophrenic patients and 858 healthy volunteers overall. The second meta-analysis included 10 studies comparing the cognitive functioning of 1,263 schizophrenics across positive and negative symptoms. Results of the first review indicated that healthy controls …

The Effects Of Constructed Wetlands On Metal Solubilization And Bioavailability In Passive Mine Remediation, Elizabeth Cochran

Electronic Theses and Dissertations

The legacy of coal mining in Appalachia has left many watersheds impacted by abandoned mine drainage. The drainage degrades streams, groundwater and habitats with acidity and toxic heavy metals. The Lowber Passive Remediation System has been in operation since 2004 to remediate high amounts of dissolved Fe, SO₄, Al, and Mn. The site consists of six settling ponds and an extensive wetlands at the finish. This study investigated the resolubilization of Fe and Mn in the wetlands and the role of bacteria in resolubilization. During three seasons, field measurements of water quality and lab analysis of Fe, Mn, …

Theology Of Arcavatara And The Eucharist: A Comparative Study, James Adeoye

Electronic Theses and Dissertations

The diversity in the world today is undeniable and quite imposing. The claim to uniqueness and universality of faith in each religious system cannot be sustained without factoring the implications and impacts of this claim on the well-being of humanity and reality hermeneutics. The postmodern world favors pluralism and encourages mutual respect for particular opinion, praxis, faith, theology and all forms of epistemology as they exist in the individual culture, religion and society. With this in mind, this work is a comparative analysis of the notion of avatars in Vaishnavism, a religious sect in Hinduism and the concept of the …

Public Health Policy: An Ethical Analysis Of Quarantine, Dina Alqahtani

Electronic Theses and Dissertations

As a public health measure quarantine has both historical and contemporary significance both in the United States and abroad. On the surface it represents a low-cost, low-tech way in which the spread of disease can be mitigated as its core requirement is that those who may have been exposed to an infectious agent are kept away from those who have not been exposed to that agent for enough time to determine whether or not infection has been spread. This has been utilized for centuries with both limited questions and scattered, inconsistent, or impossible to achieve oversight and goals. In understanding …

Role Of The Glycerophosphocholine Acyltransferase, Gpc1, In Phosphatidylcholine (Pc) Biosynthesis And Remodeling In Saccharomyces Cerevisiae, Sanket Anaokar

Electronic Theses and Dissertations

Biomembranes are permeable barriers that enclose the cell and the intracellular organelles in a cell. The selective nature of these robust barriers acts as the first line of defense towards the harsh factors that can compromise cell survival. Biomembranes primarily consist of membrane lipids that are organized into layers to form a dynamic bilayer structure. The dynamic nature of the membrane requires the synchronized modulation of lipid composition through de novo synthesis, degradation, intracellular movement, and remodeling. Phospholipids are the major membrane lipid class, and phosphatidylcholine (PC) is the most abundant phospholipid in most eukaryotic biomembranes.

PC is primarily produced …

Multifaith Families And Their Narratives Within Society, Josh Friedberg

Electronic Theses and Dissertations

The goal of this project is to nudge the conversation about interfaith families in a direction that examines the family post–interfaith dialogue. The term multifaith better represents this new aim because it encompasses all interactions and does not limit the family to the constraints of the moniker interfaith. I apply Walter Fisher’s concepts of coherence and fidelity, in coordination with family communication literature, to structure this project and to study the various aspects of a multifaith family and narrative. I also use three typologies of multifaith family (Passive/Passive, Passive/Active, and Active/Active) to better understand the variations of this family. The …

Unconventional Oil And Gas Extraction In Ohio: Regulations, Production And Water Quality, Brittany Garman

Electronic Theses and Dissertations

The Utica shale play is the main target for unconventional oil and gas extraction in Ohio. Over 2,000 wells have been drilled since the first in 2011. This rapid expansion has led to concerns over the availability of information and potential environmental impacts. An assessment of readily available data was done through an examination of the ODNR website for oil and gas regulations, permits, spud and completion reports, water usage and waste data, and complaints, as well as brine and de-icer application. Water quality testing of an exceptional warm water tributary in the Captina Creek watershed in Belmont County, Ohio …

Black Body Memory: A Philosophy Of The Talk, Autumn Redcross

Electronic Theses and Dissertations

This project offers the term Black body memory to point toward the threatened existential disposition of Black people in society today. Moreover, Black body memory points to the narrative paradigm of a shared experience. While popular conceptions theorize race as a social construction, the lived reality of Black people is frequently imbued by racialization and racism. Black body memory emerges from the intersection of the Black body articulated by Franz Fanon, Charles Johnson, and George Yancy, among others, and body memory, as described by Edward Casey and Thomas Fuchs. Black body memory is a culturally-laden and sedimented lived reality. The …

Video Games, Influence, And Identification: The Perpetuation Of Culture Through Digital Worlds, Steven Zwier

Electronic Theses and Dissertations

Video games, through their widespread popularity and appeal, transmit meaningful ideas, beliefs, and attitudes via the use of digital worlds, narratives, characters, and play. Play has always held a key role in human life, but the video game medium accentuates and accelerates the reach and impact of play on human users. Jacques Ellul’s philosophy of social propaganda and Kenneth Burke’s rhetorical theory each offer important implications to the persuasiveness of video games; however, when placed in conversation with one another, the union of Ellul and Burke leads to a more complete understanding of how video games have such an effect …

Reshaping The Theology And Praxis Of Inculturation Through Interreligious Dialogue Between The Catholic Church And African Traditional Religion In Igboland, Nigeria, Cajetan Anyanwu

Electronic Theses and Dissertations

Prior to the advent of Christianity in Igboland, the people practiced Igbo Traditional Religion. They believed in a Supreme Being (Chukwu/Chineke) who has other smaller deities as messengers including Ala/Ani the most powerful deity on earth. They revered their ancestors, who, they believe, still relate to and communicate with the living. Thus, the concept of God as ultimate reality is a dynamic existential aspect of Igbo world-view. Categorically speaking, it was short-sighted for the European missionaries to claim that Igbo people had no knowledge of God or lacked religion before the introduction of Christianity in Igboland in the …

When Humanity Meets Technology: Contemplating Neil Postman's Critique Of Advertising, Yingwen Wang

Electronic Theses and Dissertations

This project aims to contemplate Postman’s critique of advertising and offer insights to understand Integrated Marketing Communication (IMC) in today’s mediated environment. As an essential component of IMC, the history of advertising demonstrates and documents that the medium of communication has an extensive influence on IMC practices. The concern about how communication media affect human perception, understanding, and behavior, resides within the central claim of the study of media ecology. Thus, this project investigates IMC through the lens of Postman’s media ecology perspectives, and argues that Postman’s prescient ideas provide both hope and constructive insights. Moreover, Postman’s thermostatic perspective, rooted …

Unpresentable Members: The Theology And Radical Phenomenology Of The Sexual Flesh, Justin Pearl

Electronic Theses and Dissertations

Unpresentable Members begins with a wager: that a proper account of the flesh and its sexual character may not only prove philosophically fertile within its own limited domain, but may also provide insight into the theological question of the proper role and place of gender and sexual difference within communities, particularly Christian religious communities. In this regard, this dissertation has two distinct goals: one phenomenological and one theological. Phenomenologically, it offers an account of the manifestation of concrete sexual determinations not only as they objectively appear across the “body-object” (Körper, le corps) but with equal importance as …

“I Do Have A Softer Side”: A Phenomenological Investigation Of The Prisoner-Dog Relationship In The Canine Partners For Life Training Program, Kathleen Kocherzat

Electronic Theses and Dissertations

This qualitative study investigated the relationship between incarcerated dog handlers and the service dogs they trained. Six men at a large northeastern prison were interviewed during the summer of 2017; all were current or former dog trainers in the Canine Partners for Life (CPL) training program. The men were serving prison sentences ranging anywhere from several years to life without parole. The interviews focused on their lived experience, rasing and training puppies for a period up to eighteen months. The qualitative data consisted of approximately thirteen hours of transcribed interviews, which were then interpreted using the phenomenological psychological method developed …

Effects Of Temperature On Microbial Parameters Associated With Decaying Plant Litter In A Stream Microcosm Experiment, Hunter David Pates

Electronic Theses and Dissertations

Increases in mean surface air temperature under climate-change predictions are expected to affect microbial activity, as well as carbon dynamics in aquatic ecosystems. I explored responses of litter-associated decomposers along temperature ranges typical of temperate streams in laboratory microcosms simulating stream conditions. The objectives of this study were to determine (1) whether the effects of temperature on stream leaf-associated microorganisms can be explained by the Metabolic Theory of Ecology (MTE); (2) if the effects of temperature are the same across temperatures commonly found in temperate streams; and (3) if there are differences in the magnitude of responses to temperature among …

Microplastics In The Digestive System Of The Atlantic Sharpnose Shark (Rhizoprionodon Terraenovae) In Winyah Bay, Sc, Elise Virginia Pullen

Electronic Theses and Dissertations

The digestive tracts and livers of adult male Atlantic sharpnose sharks (N=16), Rhizoprionodon terraenovae, from Winyah Bay, South Carolina were examined for ingested microplastics. R. terraenovae is a small, locally abundant, coastal mesopredatory elasmobranch belonging to the family Carcharhinidae. Microfibers comprised the largest categories of plastics (94% of the total), and were found in 100% of sharks examined. The number of micro- and other plastics ranged from 34 to 75 per individual and totaled 927. The majority of plastics (40%) were blue in coloration, and 55% were <1 mm in length. Microplastics were observed on both the interior and exterior of the organs examined, and three microfibers were embedded within the stomach lining, an observation not previously reported in marine vertebrates and one which represents a potential pathway for the translocation of ingested microplastics.

Fanfiction Reviews And Academic Literacy: Potential Impacts And Implications, Regina Weiler

Electronic Theses and Dissertations

This study is meant to elucidate how fanfiction-related activities can incorporate many types of critical review, to call attention to what has been overlooked as significant forms of learning, and to understand and take advantage of the opportunities fanfiction's unconventional writing affords in lieu of more deliberate learning environments. This thesis was undertaken due to the significant gap in work done by aca-fan — a portmanteau of academic and fan— scholars who have strong links to the fanfiction community and culture. The aspects explored are the technical writing skills and techniques demonstrated in fanfiction reviews, the influence of the nontraditional …

Energy Expenditure And Stability During Self-Paced Walking On Different Slopes, Alanna Raffaelli

Electronic Theses and Dissertations

Metabolic power and cost of transport (COT) are common quantifiers for effort when performing tasks including walking and running. Most studies focus on using a range of normal walking speeds over level ground or varied slopes. However, these studies use fixed-speed conditions. Fatigue, stability, metabolic expenditure, heart rate, and many other factors contribute to normal walking speed varying over time. This study aimed to show that allowing a subject to walk with a self-paced speed should correlate to a minimum COT at a given slope. This study also aimed to determine if a preferred slope exists based on minimizing metabolic …

Motor And Sensory Characterization Of A Mouse Model Of Charcot-Marie-Tooth Type 2o Disease, Swaran Nandini

Electronic Theses and Dissertations

Dynein is an essential motor protein required for the maintenance and survival of cells. Dynein forms a motor complex to carry intracellular cargoes like organelles, growth factors, peptides, and hormones along the microtubules inside the cells. In neurons, the dynein is the retrograde motor protein that moves cargoes from the neuronal tip to the neuronal soma along the length of an axon. Dynein has an established role in neuronal nuclear migration, transport of neuronal survival signals and growth factors, organelle positioning inside neurons etc. Hence, it is not very surprising that numerous mutations in dynein have been reported in association …

The House That Credit Built: How Advertising Shaped A Culture Of Borrowing In The Decade Of Prosperity., Morgan Folden

Electronic Theses and Dissertations

This thesis is an examination of the visual rhetoric of the advertisements in 1920s America that encouraged consumers to implement payment plans to purchase commodities. It begins with an analysis of a standard advertisement found in a popular subscription journal and describes the ad’s reliance on an editorial-style layout to appeal to the rationality of the viewer, a theme common among marketing schemes of the surrounding decades. It uses an art historical approach to provide a new lens in studying capitalist economics and the provocative issue of empowerment versus confinement in the general visual representation of American housewives. The latter …

Eyes In The Field, A Seat At The Table, A Voice At The Ranch : A Study On Optimal Farm Labor Conditions., Christine Wiggins-Romesburg

Electronic Theses and Dissertations

The field of human resource development has twin obligations to promote the performance of organizations and the satisfaction and welfare of all workers. Nevertheless, agriculture appears to be an understudied industry in the field, despite this obligation and the potential for suffering experienced by workers performing crop work. This case study sought to understand the process through which a single agricultural operation fosters optimal conditions for workers engaged in labor-intensive crop production. This study found employees experienced better treatment compared to other agricultural operations, and that conditions were rich in both intrinsic and extrinsic factors. Intrinsic factors were marked by …

Developmental Changes In Reasoning About Cross-Classified Individuals., Catherine H. Mcdermott

Electronic Theses and Dissertations

Social categories allow children to make inferences about novel situations, which can then guide their interactions with others. However, this process can be complicated because individuals often belong to many different, sometimes interrelated, social categories. Four experiments examine whether children and adults differ in their willingness to classify a person as holding two social roles (e.g., a mother and a daughter), and how this influences their reasoning. Specifically, this work will examine the influence of cross-classification on inductive inferences, trust in testimony, and knowledge evaluations. The aim of these experiments is to investigate whether children privilege certain roles when reasoning …

Synthetic Methods And Biological Applications Of Nitrogen Heterocycles To Compounds Of Biological Interest., Jarrid Ronnebaum

Electronic Theses and Dissertations

Thalidomide analogues were synthesized utilizing optimized click conditions from 3-azidoglutarimide and an array of arylacetylenes or N-ethynyl/N-propargyl phthalimide derivatives. The intermediate, 3-azidoglutarimde, was pivotal and yielded a new and scalable synthesis. The reaction conditions utilized a copper sulfate/sodium ascorbate system in aqueous tetrahydrofuran to propagate the dipolar cycloaddition reactions between the azidoglutarimide and the alkynyl coupling partners. The first explored substrates were substituted arylalkynes to optimize the click reaction. Arylalkynes selected were to exhibit similar electron deficient rings to mimic phthalimide. Along with the synthesis of click thalidomide analogues, click analogue of the antiangiogenic and more potent …

Evaluating The Water Quantity And Quality Performances Of Underground Gravel Filter Basins., Jihad A. Hallany

Electronic Theses and Dissertations

Underground gravel filter basins (UGF basins) are subsurface structures that are used for detention, filtration, and infiltration of stormwater runoff in urbanized areas. The application of these structures is recommended in highly developed urban areas, where land is not available or it is too expensive for surface-level green infrastructures such as stormwater ponds, bio-retention, and infiltration trenches. Objectives of this study are to assess and analyze the effectiveness of two (2) UGF basins in reducing the stormwater runoff peak flow, and to assess water quality parameters in a high-density residential area. The experimental site is located at Red Mile Village, …

Anthropogenic Landscapes Of Amazonia : A Spatial Analysis Of Landscape Modification And Settlement Organization At Macurany, Brazil., M. Grace Ellis

Electronic Theses and Dissertations

Anthropogenic landscapes are the product of complex human-environment processes that form distinct features in the landscape, which materially preserve and reflect human behavior. Anthropogenic landscapes in Amazonia likely date back to human colonization of the region around 16,000 BP. Since colonization, humans have been marking, modifying, managing, and engineering the landscape resulting in a mosaic of anthropogenic landscape features across Amazonia. The diversity of ancient landscapes documented in Amazonia reflects the cultural heterogeneity that existed in the past. This research explores the complex human-environmental processes that form distinct, identifiable, lasting features on the landscape and what these features can illuminate …

Development Of Bar-Peptide Nanoparticles And Electrospun Fibers For The Prevention And Treatment Of Oral Biofilms., Mohamed Yehia Mahmoud

Electronic Theses and Dissertations

Background: Periodontal diseases are globally prevalent inflammatory disorders that affect ~47% of U.S adults. Porphyromonas gingivalis (Pg) has been identified as a “keystone” pathogen that disrupts host-microbe homeostasis and contributes to the initiation and progression of periodontitis. Pg associates with oral streptococci in supragingival plaque and this interaction represents a potential target for therapeutic intervention. Previously our group developed a peptide (designated BAR), that potently inhibits Pg/Streptococcus gordonii (Sg) adherence in vitro and Pg virulence in a murine model of periodontitis. While efficacious, BAR (SspB Adherence Region) provided transient inhibition and required higher concentrations of BAR to disrupt established …

Preference For Odor-Taste Mixtures Is Dependent On Previous Experience., Kelsey Allison Mcqueen

Electronic Theses and Dissertations

The perception of flavors occurs when a tastant is simultaneously detected and associated with an odorant (i.e., odor-taste mixture). Sampling an odor and taste together results in a congruent odor-taste mixture. Mixing an odor and taste from different congruent odor-taste pairs results in incongruent odor-taste mixtures. Creation of a flavor percept requires sampling a novel chemosensory stimulus; however, mammals exhibit robust neophobic behavior when presented with new chemosensory stimuli. To determine preferences for novel odorants and experienced odor-taste mixtures, we employ a two-bottle brief-access preference task where two chemosensory stimuli are presented simultaneously. We found that rats show a preference …

Point Cloud Technology For Analysis Of Existing Structures, Jacob Cano

Electronic Theses and Dissertations

For this thesis, a study was completed on two different structures on the UCF Orlando campus through the use of both structural plans and point cloud technology. The results sought to understand the viability of point cloud technology as an accurate tool for the static and dynamic modal analysis of existing structures. For static analysis, a portion of the framing of Spectrum Stadium was rendered, modeled, analyzed and compared to a previous case study. The results emphasized how different users can render dissimilar member sizes and lengths due to human judgment on point cloud visuals. The study also found that …