Digital Commons Network^™

Phospholipase D Signaling In T Cells, Uma Chandrasekaran

Dissertations

Antigen stimulation of T lymphocytes induces the activation of phospholipase D (PLD) signaling. Phospholipase D (PLD) is a phosphodiesterase that catalyzes the conversion of phosphatidyl choline (PC) to phosphatidic acid (PA). PA is an important lipid second messenger and is known to mediate a variety of cellular functions. However, the specific role of PA in T lymphocytes has not been established. Previous studies indicated differential requirement for TCR induced PLD signaling in regulatory and non-regulatory T cells. Inhibition of TCR induced PLD signal preferentially suppressed the growth of non-regulatory T cells while allowing the proliferation of regulatory T cells in …

Resurrecting The Past, Constructing The Future: A Historical Investigation On The Formation Of A Greek National Identity In Schools, 1834-1913, Theodore G. Zervas

Dissertations

This dissertation research combines archival data and historical methods and analyzes how schooling and education in Greece between 1834 and 1913 sought to shape a Greek national identity. The goal of this project is to present a historical analysis, that has thus far been absent from scholarship on the subject, and to convey how the adoption of a common national history in Greece, with roots to ancient Greece, assisted in the shaping of a Greek national identity. The timeframe this project examines is significant because it covers an important portion of Modern Greek history. The beginning of the modern state …

B Lymphocyte Development In Galt, Venkata Arunachalam Yeramilli

Dissertations

In rabbits, the primary antibody repertoire is generated in the gut-associated lymphoid tissues (GALT), where bone marrow (BM)-derived B cells undergo a proliferative expansion and somatically diversify the immunoglobulin genes. Unlike in other species, B lymphopoiesis in rabbit arrests a few months after birth, and it is unclear how the peripheral B cell compartment is maintained when there is no influx of newly-made B cells from the BM.

For my dissertation, I investigated how B cells develop in the GALT of rabbits, and how they are maintained in adults after the arrest of lymphopoiesis. To identify cellular signals that promote …

Ethanol Impairs Mechanisms Of Macrophage Phagocytosis And Cytokine Production, John Karavitis

Dissertations

Extensive evidence indicates that alcohol (ethanol) consumption affects human health by altering normal physiological functions of the immune system. This study investigated the effect of a single in vivo exposure of macrophages to clinically relevant levels of ethanol (1.2 and 2.2 g/kg). Following 3 hour exposure, both doses of ethanol decreased ex vivo TNFα production by splenic and alveolar macrophages (AMs). Interestingly, the higher dose of ethanol resulted in sustained suppression of LPS-induced TNFα production at 3 and 6 hours post ethanol administration, as well as decreased IL-6 and IL-12 production after 6 hours, compared control treated groups. LPS or …

In The Margins: Thresholds Of Text And Identity In U.S.-Mexico Border Literature, Allison E. Fagan

Dissertations

My project links discussions of U.S.-Mexico border literature's emphasis on marginalized identity with the growing textual studies interest in the marginal, often-invisible processes which aid the production and shape the reception of books. The dissertation not only calls attention to textual instability, or the places where the differing and even opposing intentions of authors, publishers, and editors often become strikingly clear, but also focuses on the political, racial, ethnic, and social instabilities inherent in publishing the work of borderlands writers. It advocates and advances a sustained attentiveness to the conditions under which border literature can and does get produced. Authors …

Uncommon Sense In Renaissance English Literature, Eric Byville

Dissertations

My project explores the distinctive union of Senecan tragedy and Elizabethan satire in Renaissance English drama, particularly the works of John Marston and William Shakespeare. Unlike Ben Jonson, who incorporated both Senecan tragedy and Elizabethan satire in his drama but did so in different plays (Catiline, Every Man Out), Marston and Shakespeare combined the two traditions in one and the same play, such as the former's Antonio's Revenge (1600) and The Malcontent (c. 1603) and the latter's Troilus and Cressida (1601) and Timon of Athens (c. 1606). They recognized and exploited a deep compatibility between the two traditions, a compatibility …

Your Change Is Still Behind: Futurity In Early Modern Literature, Tripthi Pillai

Dissertations

A study of Renaissance literature's engagement with temporality, my project is a critical evaluation of the concept of early modern futurity, of which I propose three categories: "Material futurity"; "Biological futurity"; and "Political futurity." In the moments that I identify in texts composed during the Tudor and early Stuart reigns in England, I demonstrate that the future--as an idea--structures individuals' actions and ruptures social formations. Futurity, which I define as a play of multiple desires that exist simultaneously within our present beings, is a volatile agent of imagination in early modern literature. Futurity collides with the cultural sites of memory …

Storied Memories: Memory As Resistance In Contemporary Women's Literature, Sarah Katherine Foust Vinson

Dissertations

This dissertation examines the power for resistance contained within narratives of personal memory. By applying current psychological concepts of autobiographical memory theory to eight contemporary women's novels, Carole Maso's The Art Lover; Margaret Atwood's The Handmaid's Tale; Dorothy Allison's Bastard Out of Carolina; Edwidge Danticat's Breath, Eyes, Memory; Barbara Kingsolver's The Poisonwood Bible; Arundhati Roy's The God of Small Things; Gloria Naylor's The Women of Brewster Place; and Toni Morrison's Paradise, I argue that it is in literature that we can examine both the workings of memory and the ways that authors use concepts of memory in their works to …

Characterization Of Tram, A Required Bacteroides Fragilis Conjugal Apparatus Protein That Interacts With The B. Fragilis Putative Coupling Protein Bcta And The B. Fragilis Relaxase Protein Bmph, Mai Thi Thanh Nguyen

Dissertations

Bacteroides spp. organisms, the most prominent bacteria of the human colon, are reservoirs of antibiotic resistance genes which promiscuously transfer within and from the genus via conjugation. The B. fragilis clinical isolate LV23 harbors a 37kb conjugative transposon, BTF-37. Two important conjugal apparatus proteins encoded by BTF-37 are BctA, a predicted coupling protein (CP) that powers DNA translocation, and ORF7 (TraM). In this study, we demonstrated that TraM exhibits characteristics of a required conjugal apparatus protein including 1) upregulated expression under conjugation conditions; 2) localization to the bacterial inner membrane; 3) interaction with the putative coupling protein BctA and the …

Morphogenesis Of The Bacillus Anthracis Spore, Michael Mallozzi

Dissertations

With the ability to shut down metabolism, survive exposure to high degrees of heat, ultra-violet and ionizing radiation, digestive enzymes, and antimicrobials, the bacterial spore is one of the most-resistant forms of life on earth. Although most spores are harmless, several species' spores cause serious diseases such as tetanus, anthrax, gas gangrene, botulism, and diarrhea. Spore-forming bacteria differentiate into spores in response to stresses (especially starvation) in a multi-stage developmental pathway involving the coordinated expression of hundreds of genes and the formation of specialized protective organelles which surround and protect the spore during dormancy. The Bacillus anthracis spore (the causative …

Involvement Of The Nmda Receptor In Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta In Vitro, Robert Matthew Mitchell

Dissertations

Alzheimer's disease (AD) is a progressive, mentally crippling, and eventually fatal form of dementia with growing prevalence in aging populations. In 2009 it was estimated that 5.3 million Americans have AD, with 5.1 million older than age 65 and 200,000 under 65. That accounts for 1 in 8 adults over 65. Furthermore, AD costs Americans 148 billion dollars in direct expenses, and is the leading cause of dementia and the 6th leading cause of death. Since improved medical care in general is increasing average life span and age is the primary risk factor for AD, there is need for basic …

Hindbrain Serotonin Neurons Activate 5-Ht1a Receptors In The Nucleus Tractus Solitarius (Nts) To Modulate Sympathetic And Ventilatory Recovery Following Hypotensive Hemorrhage, Ling-Hsuan Kung

Dissertations

Trauma is the leading cause of death of young people in the United States. Most such deaths result either from the initial blood loss or from secondary reperfusion injury following resuscitation.

Currently, the standard treatments for hypovolemic shock include volume resuscitation and using of vasoconstrictors to raise pressure. However, these treatments can exacerbate reperfusion injury, and require technical care when apply to patients. Therefore, novel therapies that can safely restore perfusion pressure are needed.

Our lab has found that 5-HT1A-receptor agonist, 8-OH-DPAT, increases perfusion pressure and improves acid-base balance in hypovolemic rats by stimulation of sympathetic-mediated increases in venous tone. …

Interpretive Teleology Without Eschatology: A Study Of The Hermeneutic Strategies Of Nietzsche's Genealogical Project, Darin Sean Mcginnis

Dissertations

In contemporary philosophy, there exists a vigorous debate between those thinkers who advocate the need for a truth that exists outside of historical forces and those who hold that all understanding must be historical in its basis. My research is focused on deciphering this problem by providing a description of how understanding and interpretation occur. More specifically, I have proposed a project that explores how the philosophical writings of Friedrich Nietzsche can give some insight into this problem of understanding truth. I argue that Nietzsche develops a method of interpretation - a hermeneutics - that focuses on the manner in …

Camkii-Mediated Phosphorylation Of The Inositol 1,4,5-Trisphosphate Receptor At Serine-150 Results In Decreased Channel Activity, Joshua Thomas Maxwell

Dissertations

One mechanism by which calcium is mobilized from intracellular stores is via the activation of inositol 1,4,5-trisphosphate receptors (InsP3Rs) by the second messenger, inositol 1,4,5-trisphosphate (InsP3). InsP3 is produced when certain factors bind to G protein-coupled receptors on the plasma membrane, causing activation of phospholipase C which cleaves InsP3 from its membrane tether, allowing InsP3 to diffuse through the cytoplasm to bind to its receptor. Activation of InsP3Rs leads to release of calcium into the cytoplasm of the cell, where it can activate a multitude of signal transduction cascades and a variety of local and global cellular events. One such …

Doubting Thomas: A Study Of Thomas Hobbes's Post-Restoration Dialogues, Adam George Yoksas

Dissertations

This study explores the possibility that Thomas Hobbes's post-Restoration writings have a teaching that is somewhat different than the teaching contained in his scientific treatises. Specifically, Hobbes seems to express doubt in his dialogues that his science as outlined in Leviathan and elsewhere is a realistic solution to the problems of the commonwealth. His knowledge of the English Civil War and the peace that followed may have been instrumental in reorienting Hobbes towards a more pragmatic and realistic philosophy that recognized the limits of science to create stability in the political arena. The Hobbes of the dialogues seems to focus …

Neuropsychological Assessment Of Executive Functioning And Its Association With Depressive Symptomology, Erica Jean Kalkut

Dissertations

The current study explored the construct of executive functioning and neuropsychological measurement techniques used to assess executive functioning (EF). Two current comprehensive measures of executive functioning include the Behavior Rating Inventory of Executive Functioning-Adult Version (BRIEF-A) and the Delis-Kaplan Executive Functioning System (D-KEFS). The BRIEF-A is a self-report questionnaire that reportedly assesses behaviors associated with EF, and the D-KEFS is a battery of tests that are objectively administered by a trained examiner to directly measure different manifestations of EF ability. This study examined the relationship between gender and general intellectual ability on EF and investigated each measure's construct validity in …

Development And Validation Of The Workplace Intergenerational Atmosphere Scale, Scott P. King

Dissertations

This dissertation details the development and validation of the Workplace Intergenerational Atmosphere (WIA) scale over two studies. Given the growing number of older adults in the American workforce and the possibility of four generations working side by side, the WIA scale was designed to measure attitudes and perceptions about workers of different ages in the workplace. In Study 1, using a sample of workers from a non-profit organization, 23 initial items were reduced to 18, including five subscales: Intergenerational Contact, Workplace Intergenerational Retention, Positive Affect, Workplace Generational Inclusiveness, and Lack of Stereotypes. The relationships between WIA scores and mentoring, perceptions …

Immigration As A "Theologizing Experience": Spiritual Well-Being As A Moderating Factor In Migratory Grief And Acculturation, Irma A. Sharp

Dissertations

The purpose of this study was to investigate the relationship of spiritual well-being to migratory grief and acculturation. The study employed a cross-sectional design and a convenience sampling method. Data were collected from 75 Mexican immigrant adult education students in the city of Chicago. Instruments used to collect data were a demographic form, Spiritual Well-Being Scale, Migratory Grief and Loss Questionnaire, and the Stephenson Multigroup Acculturation Scale. All instruments were translated into Spanish, the native language of the participants. Multiple regression analysis was used to test the moderator effects of existential well-being and religious well-being, the two sub-scales of the …

The Impact Of Social Stigma On The Therapeutic Relationship For Latino Clinicians: The Elephant In The Room?, Mauricio Jose Cifuentes

Dissertations

Social stigma is consistently mentioned in the literature as one of the barriers

preventing Latinos from seeking, accessing and remaining in mental health care. This

study focuses specifically on social stigma as a barrier to remain in psychotherapy.

Social stigma is understood as the internalized fear of severe social disapproval for

behaving against acceptable cultural meaning systems. With intersubjective theory as

the analytical framework, this study primarily explores, through a series of focus groups

with Latino mental health service providers of Latino clients, the perceptions those

practitioners have regarding the influence of social stigma on the therapeutic

relationship and the …

The Complexities Of Attachment, Peer Rejection And Gender Within A Middle School Dynamic - A Glimpse At Early Adolescents And Their Significant Relationships, Barbara Ann Mestling

Dissertations

This was a mixed method two phase explanatory study of attachment, peer rejection and gender in a non-clinical middle school population. The purpose of the study was to illustrate the relationship between these variables with the assumption that there would be differences in attachment style between rejected and non-rejected students and further differences by gender. The Behavioral Systems Questionnaire (BSQ) and the Children's Self-Experience Questionnaire-Self-Report (CSEQ-SR) were utilized to determine interview subjects. A Parent Demographic Form provided background, life experience and social functioning information. There were challenges in the use of both instruments for this study's purposes. Although there were …

The Relationship Among Adult Attachment Styles, Shame, Dissociation, And Abuse Characteristics In Women Survivors Of Intrafamilial Child Sexual Abuse Perpetrated By A Parental-Figure, Grace H. Tomas-Tolentino

Dissertations

The consequences of intrafamilial child sexual abuse (CSA) often evolve beyond the termination of abuse and pervade into adulthood, posing complex and enduring consequences for survivors (Courtois, 1999; Briere, 1992; Herman, 1981, 1991; van der Kolk & Kadish, 1987; Chu & Dill, 1990). The concepts of attachment, shame, and dissociation- in the context of childhood sexual abuse-are significant areas of study when working with adult survivors. The present study included 49 women with a history of childhood sexual abuse perpetrated by a parental-figure. The purpose of the study was to identify the relationships among adult attachment styles, shame, dissociation, and …

The Practice And Meaning Of Communitarian Spirituality In The Focolare Movement, Nori Henk

Dissertations

The purpose of this study is to explore how individuals come to embrace the FM spirituality as radical, making the spiritually meaningful and plausible for social change through a communitarian lifestyle that affects their everyday life. Within the sociological tradition of studying religion and social movements, this study addresses how religiously-motivated, "non-elite" individuals can be collectively recruited and mobilized into life-long agents of change. My study is based on seventy-five interviews and fieldwork at three sites in Chicago, New York and Los Angeles.

In the dissertation, I addressed the following research questions: 1. If a member is defined as one …

In The Driver's Seat: Living And Working As A Trucker, Cassandra Lively

Dissertations

This project examines the work and personal lives of truck drivers. Using data from fieldwork at a Midwestern trucking company, along with interviews with 38 drivers, dispatchers, company management and spouses and partners of drivers, I explore the questions: Thirty years out from deregulation, how are drivers' lives affected by the economic state of the industry? How do drivers and unions interact with public policy and company regulations that shape their on-the-job autonomy and their own and others' safety on the road? What are the dynamics of the industry around race, gender and sexuality? How does working in a high-stress, …

Using Matching Methods From Both Fisher's Experimental Design And Rubin's Causal Model To Compare Between Two Medical Facilities With Extremely Skewed Number Of Subjects, Gideon D. Bahn

Dissertations

The present study deals with the problem of comparison between a two medical facilities' with extremely skewed sample sizes from non-experimental study. The data came from a study of rehabilitation interventions with patients diagnosed with cardiac and pulmonary issues who received treatment either in inpatient rehabilitation facilities (IRFs) or in skilled nursing facilities (SNFs). Due to inclusion and exclusion criteria, however, the study had failed to recruit sufficient number of participants between two comparison groups: 319 from IRFs and 27 from SNFs. As a result, the main hypothesis of the study was not tested due to the disparity of the …

The Effect Of Urban Hassles On The Subjective Well-Being Of Low-Income Urban Adolescents, Kimberly Vacek

Dissertations

Low income urban youth have been identified as an understudied and important population to explore. The psychological effects of stress on the well-being of children and adolescents are of particular interest, and the stressors faced by low income urban adolescents are unique in that they are more chronic in nature and due to adverse environmental circumstances. While researchers have examined the effect of stress on the subjective well-being of low income urban adolescents, none have done so utilizing a measure of stress developed specifically to assess the unique stressors experienced by such populations. The Urban Hassles Index (UHI) is a …

The Use Of Behavioral Agreements By Senior Student Affairs Officers And Counseling Center Directors To Manage Student Mental Health Concerns And Minimize Threatening Behavior, Douglas A. Geiger

Dissertations

This qualitative investigation examines the use of behavioral agreements by Senior Student Affairs Officers and Counseling Center Directors to manage student mental health concerns and minimize behavior that poses threats to campus communities. Six pairs of Senior Student Affairs Officers and Counseling Center Directors at the same institution were interviewed for this study. In addition, documents concerning mental health and threat assessment policy and protocols are also examined and discussed. An expanded theory of practice known as Student Intervention Facilitators is presented as an option to mandated psychotherapy.

The Impact Of Person-Centered Communications On Political Candidate Evaluation: An Experimental Investigation, Randall A. Renstrom

Dissertations

"Person-centeredness" refers to how empathetic and warm a person's communication style is. Although the role of person-centeredness has been documented in various areas concerning interpersonal relations, person-centeredness has not been explored in the political realm. This project investigated how person-centered communications can influence impressions and evaluations of political candidates. In the first study, person-centered (PC) messages were shown to impact candidate trait ratings. Candidates using low PC messages were associated with more instrumental traits but fewer socio-emotional traits, while high PC candidates were assumed to have more socio-emotional traits but fewer instrumental traits. Similar results were found when participants rated …

Sea-Cards For The Impetuous Muse: A Reading Of Shaftesbury's Characteristicks, Travis Sean Cook

Dissertations

Characteristicks of Men, Manners, Opinions, Times, by Anthony Ashley Cooper, Third Earl of Shaftesbury, marks an important dissent from the general trend of early modern philosophy. This dissertation argues that Shaftesbury's book undertakes a restoration of the classical understanding of philosophy in contradistinction to the understanding presented by the writings of Descartes, Hobbes, Locke, and other modern thin0kers. According to Shaftesbury, modern philosophy introduces a method of radical skepticism in order to combat the moral and political effects of Christianity. This methodical skepticism, however, turns out to be at least as corrosive to moral and political life as the worldview …

I Am Black And Beautiful: An Examiniaton Of The Black Coptic Church As The Manifestation Of Liberation Theology, Leonard Mckinnis

Dissertations

What does the Black Coptic Church have to offer the study of Black theology? This is the essential question this dissertation seeks to examine through a descriptive and constructive analysis. I submit the doctrinal formulation of black liberation theology is locatable within the Black Coptic Church, which was founded, and still boasts its largest membership in Chicago. This is the tradition that has informed my own faith background and has played a tremendous role in my earlier theological convictions. In fact, I was attracted to this tradition as a young child because it seemed to offer its adherents a sense …

Deconstructing Ihf-Mediated Inhibition Of The Complex Acs Promoter, David S. Thach

Dissertations

acs encodes a high affinity enzyme that permits survival during carbon starvation. As befits a survival gene, its transcription is subject to complex regulation. Previously, the Wolfe lab reported that CRP activates acs transcription by binding tandem DNA sites located upstream of the major acsP2 promoter and that the nucleoid protein IHF binds three specific sites located just upstream. The most proximal site (IHF III) exhibits reduced transcription compared to the full-length promoter or to a construct lacking all three IHF sites. The goal of my research was to understand how IHF III inhibits CRP-dependent acs transcription. First, I helped …