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Heart And Sole: The Functional Role Of Fast-Skeletal Myosin Binding Protein-C In Cardiac And Skeletal Muscle, Brian Leei Lin

Dissertations

The goal of my dissertation was to compare and contrast the function of all three major isoforms of Myosin Binding Protein-C (MyBP-C): slow-skeletal, fast-skeletal, and cardiac (ssMyBP-C, fsMyBP-C, and cMyBP-C, respectively), with a focus on the least characterized isoform, fsMyBP-C. Using a variety of ex vivo, in vitro, and in silico methods, my research demonstrated that the N-terminal region of all MyBP-C isoforms bind to actin and shift tropomyosin, thus activating the thin filament during contraction. Furthermore, each isoform differentially activated the thin filament over isoform-specific ranges of Ca2+: slow-skeletal activates at low Ca2+, fast-skeletal activates at higher Ca2+, and …

Coping With Trauma: Reflections From Angolan Refugee Returnees, Michael Robert Milco

Dissertations

Millions of refugee families experience multiple migrations resulting in various degrees of trauma and stress. Each reacts to these challenges and hardships in unique ways. This dissertation research was designed to investigate the various coping strategies Angolan refugee returnees used in dealing with the traumas they experienced as a result of their various migrations. Through the lens of an ecosystem theory, the author developed research questions designed to learn “How Angolan Refugee Returnees Cope with Trauma?” Sixteen Angolan refugee returnees were interviewed in this qualitative phenomenological study. The results of the study narrowed down the most specific themes refugees used …

The Impact Of Altered T Cell Receptor—Peptide-Major Histocompatibility Complex Interactions On Antigen Recognition And T Cell Function, Timothy T. Spear

Dissertations

Adoptive cell transfer (ACT) using T cell receptor (TCR) gene-modified T cells is an exciting and rapidly evolving field. Numerous basic science and clinical studies have demonstrated various levels of feasibility, safety, and efficacy using TCR-engineered T cells to treat cancer and viral infections. Genomic instability of targeted diseases, however, requires effective and safe TCRs to cross-recognize mutated antigens while minimizing on- or off-target toxicities. Thus, improvements to T cell-based therapeutics mandate a broader understanding of the principles governing antigen recognition. This dissertation addresses critical biologic questions evaluating which parameters are most important in facilitating antigen recognition, and how alterations …

Restoring Trust: A Grounded Theory Study Of Cyberbullying Among Young Women, Nancy H. Camp

Dissertations

Cyberbullying is a global and national public health issue with the potential to affect the healthy social and emotional development of adolescents and young adults. There has been an 80% increase in social media use in 18-29 year olds between 2004 and 2014 (Gahagen, Vaterlaus, & Frost, 2016). In a study of 14-24 year olds (MTV/AP, 2011), 76% identified cyberbullying as a serious problem, with more than 56% reporting they have experienced cyberbullying. Cyberbullying research has been conducted predominantly with adolescents (ages 11-18 years), however scant research has been conducted with older adolescents and young adults (ages 18-30 years). This …

What Is The Process Of Relational Work Of The Nurse?, Daniela Terrizzi Defrino

Dissertations

The process of how nurses work in relationships to accomplish their work is presented in this dissertation. This study has made the relational work process of nurses explicit. While research demonstrates that increased nurse staffing is associated with better patient outcomes and with nurses experiencing less burnout and job dissatisfaction, the process is not explored in the empirical literature.

The research question was: “What is the process of relational work of the nurse?” Data collection and analysis conformed to the process of classical grounded theory. Interviews were face to face with 23 registered nurses working as direct care staff nurses …

Trauma In The Classroom: Teachers' Perspectives On Supporting Students Experiencing Child Traumatic Stress, Kassandra Reker

Dissertations

Each day, students across the nation carry personal trauma histories into the classroom. According to the Substance Abuse and Mental Health Services Administration (SAMHSA, 2014), trauma “results from an event, series of events, or set of circumstances that is experienced by an individual as physically or emotionally harmful or threatening and that has lasting adverse effects on the individual’s functioning and physical, social, emotional, or spiritual well-being.” With nearly half of all children experiencing at least one adverse childhood event (Child and Adolescent Health Measurement Initiative, 2013), teachers’ approach to addressing trauma in the classroom is critical. Yet our understanding …

A Concurrent And Longitudinal Examination Of A Bio-Neuropsychosocial Model For Predicting Medical Adherence And Responsibility In Youth With Spina Bifida, Alexandra Psihogios

Dissertations

Objective: The purpose of this multi-source, multi-method study was to examine biological, neuropsychological, and social (i.e., family dynamics and social adjustment) predictors of medical adherence and responsibility in a pediatric spina bifida (SB) sample.

Methods: One hundred forty youth with SB (53.6% female; M age = 11.40 at Time 1) and their caregivers participated in two study time points (Time 2 occurred two years after Time 1). Youth and their caregivers completed several questionnaires regarding medical self-management, family functioning, child social adjustment, and child executive functioning. Teachers completed a parallel measure of child executive functioning. Children completed a brief battery …

Consequences Of Estrogen Receptor Beta Phosphorylation In The Aged Female Brain And Heart, Elena Pinceti

Dissertations

Female life expectancy in the United States has steadily increased and now averages 81 years. Meanwhile, the age at which women reach menopause remains constant at 51 years. Both neurological and cardiovascular disorders increase following menopause, affecting women’s quality of life and leading to large health care costs. Estrogens are neuroprotective and cardioprotective for women, however when administered long after menopause, they fail to improve their health.

The effects of estrogen are mediated by Estrogen Receptor α (ERα) and Estrogen Receptor β (ERβ). Evidence supports that ERβ plays an important role in neuroprotection and cardioprotection, but aspects of ERβ molecular …

Mechanistic Variations Of The Bronsted Linear Free Energy Relationships For Nonezymatic Nucleotidyl Transfer Reactions, Zheng Zhang

Dissertations

As the essential enzymes in human bodies, DNA polymerases play a significant role in DNA replication, repair, genetic recombination, and reverse transcription. In 1956, the enzyme of DNA polymerase I, also named as Pol I, was discovered by Arthur Kornberg and colleagues. Subsequently, the Noble Committee had decided that the Noble Prize in Physiology or Medicine for 1959 was to be awarded to Kornberg for his excellent original work that describes the DNA replication process whereby the DNA polymerase copies the nucleotide sequence of a DNA template strand. Because of the complex enzyme structure in the DNA polymerase, it is …

Managing Workers Who Are Deaf: A Phenomenological Investigation Of Hearing Supervisors, Hayley Sneiderman Stokar

Dissertations

This study examines the experience of hearing managers of Deaf employees in the restaurant sector, specifically as it relates to accommodation and social integration. Deaf workers who use American Sign Language differ from their hearing peers with regard to communication style, language choice, and need for accommodation. Responsibility for social integration and logistical accommodation falls largely on managers, who may be unfamiliar with the needs and capabilities of Deaf workers. The aim of this study is to generate knowledge about the accommodation and social integration experiences of managers with Deaf workers that can benefit those unfamiliar with these phenomena. The …

The Psychological Impact Of Smartphones: The Effect Of Access To One's Smartphone On Psychological Power, Risk Taking, Cheating, And Moral Orientation., Amanda Christine Egan

Dissertations

Egan and Larson (2015) found that access to one’s smartphone resulted in an increase in one’s sense of psychological power. Psychological power is associated with a variety of behavioral outcomes, many of them moral in nature (Keltner, Gruenfeld, & Anderson, 2003). This dissertation attempted to conceptually replicate the findings obtained by Egan and Larson (2015) and to extend them by testing whether smartphone-induced power had moral implications. Specifically, Study 1 tested whether access to one’s smartphone increased psychological power, and in turn promoted risk taking and a shift in moral orientation. Study 2 tested whether access to one’s smartphone increased …

The Amino Terminal Region Of Cardiac Myosin Binding Protein-C Is Necessary For Cardiac Function, Thomas Lawrence Lynch

Dissertations

Cardiac myosin binding protein-C (cMyBP-C) is a thick filament-associated protein that has been suggested to regulate cardiac contraction via its amino terminal (N’) region. Following ischemic injury to the heart, cMyBP-C is cleaved into a predominant N’ fragment consisting of domains C0 through C1 and the first 17 residues of the M-domain that is referred to as C0-C1f. However, the necessity of the N’-C0-C1f region of cMyBP-C in regulating cardiac function in vivo has not been elucidated. I hypothesized that the N’-C0-C1f region of cMyBP-C is critical for normal cardiac function in vivo. To test this hypothesis, transgenic (TG) mice …

The Utilization Of Liquid Chromatography Tandem Mass Spectrometry And Related Techniques For The Analysis And Identification Of Emerging Contaminants In Aqueous Matrices, Matthew Reichert

Dissertations

Environmental pollutants can be found in many ecosystems and cover many different compound classes. The Environmental Protection Agency is responsible for monitoring and regulating several of these classes of compounds which daily enter the environment. However, there are still hundreds, if not thousands, of compounds present in the environment which have yet to be regulated or even identified. The discovery and identification of these unknown emerging pollutants is crucial for the prevention of potential human health risks and irreversible ecological damage.

The research presented is divided into two projects. The first part of this research investigates the disinfectant 3-Bromo-1-chloro-5,5-dimethylhydantoin, which …

Use Of Video Games In Patients' Self-Management Of Pain: A Feasibility Study, Janet Donnelly Phd(C), Rn-Bc, Acns-Bc, Pccn

Dissertations

Background: Pain affects more than 75 million Americans and is the primary reason people seek medical attention. Pain is a common cause of disability and diminished quality of life. While anecdotal evidence exists regarding nurses’ use of distraction therapy activities in pain management, little empirical research data is available.

Purpose: To examine the effects of video game use (VGU) on pain perception, pain interference perception and perceived self-efficacy in pain management in adult inpatients.

Conceptual Model: The conceptual model is based on Self-efficacy Theory (Bandura, 1995). The antecedents of the concept of distraction therapy with use of VGs in patients’ …

Deposition And Characterization Of Hermetic, Biocompatible Thin Film Coatings For Implantable, Electrically Active Devices, Robyn K. Sweitzer

Dissertations

Retinal prostheses may be used to support patients suffering from Age-related macular degeneration or retinitis pigmentosa. A hermetic encapsulation of the poly(imide )-based prosthesis is important in order to prevent the leakage of water and ions into the electric circuitry embedded in the poly(imide) matrix. The deposition of amorphous aluminum oxide (by sputtering) and diamond like carbon (by pulsed laser ablation and vacuum arc vapor deposition) were studied for the application in retinal prostheses. The resulting thin films were characterized for composition, thickness, adhesion and smoothness by scanning electron microscopy-energy dispersive spectroscopy, atomic force microscopy, profilometry and light microscopy. Electrical …

To Be Black, Caribbean, And American: Social Connectedness As A Mediator To Racial And Ethnic Socialization And Well-Being Among Afro-Caribbean American Emerging Adults, Gihane Emeline Jeremie-Brink

Dissertations

Racial and ethnic socialization are integral to the functioning and parenting process in ethnic minorities’ families (Brown & Krishnakumar, 2007; Hughes, Rodriguez, Smith, Johnson, Stevenson, & Spicer, 2006). Unfortunately, there is no scholarly consensus with respect to definitions and operations for racial and ethnic socialization which then evidences several conceptual and methodological shortcomings in racial and ethnic socialization research (Brown, 2004). Furthermore, very little empirical research has used these findings in relation to the socialization processes of first- and second-generation Afro-Caribbean emerging adults.

The purpose of this study was to test the roles of both racial socialization and ethnic socialization …

The Parent Advisory Council For Spanish-Speaking Parents: A Program Evaluation, Alison Alves

Dissertations

English Language Learning (ELL) students comprise the largest growing group within schools in the United States (Arias & Morillo-Campbell, 2008; Kindler, 2002 as in Ochoa & Rhodes, 2005). Such large numbers of Culturally and Linguistically Diverse (CLD) students within schools has led governing institutions to mandate efforts be made to establish greater connections to these families (Tellez & Waxman, 2010). One of these mandating documents is the Illinois State Board of Education Administrative Code which pertains to Transitional Bilingual Education (TBE) of CLD students. This code states that schools with a TBE program must create a parent advisory committee that …

Olympic Bids, Professional Sports, And Urban Politics: Four Decades Of Stadium Planning In Detroit, 1936-1975, Jeffrey R. Wing

Dissertations

Between 1936 and 1975, political and business leaders in Detroit tried to gain support for the financing and construction of a municipal stadium. The stadium plan originated as part of an attempt to bring the Summer Olympics to the city. The municipal stadium was to serve as the main Olympic stadium and be used for a variety of events after the Olympics were finished. Later, after Detroit leaders gave up on the Olympics after several failed bids, the stadium plan evolved into a domed facility on the downtown riverfront for the Detroit Tigers and Detroit Lions, the city’s professional baseball …

“My Masculinity Is A Little Love Poem To Myself”: Trans*Masculine College Students’ Conceptualizations Of Masculinities, T.J. Jourian

Dissertations

Men and masculinities studies in higher education are gaining prominence within the literature, illuminating how cisgender men understand and grapple with masculinity on college campuses. Additionally, the increased visibility of trans* students has fueled the expanding scholarship and attention to their experiences, often however centering on White gender-conforming trans* students with little if any focus on their multiple and intersecting identities. This phenomenological study seeks to bridge these two areas of literature, by investigating how trans*masculine students understand, define, and adopt a masculine identity, and how that identity is informed by their various intersecting and salient identities. Dominant masculinities function …

Parental Involvement, Socio-Economic Status And Students' Perceptions Of The Classroom Learning Environmnet As Predictors Of 8th Grade Students Academic Achievement: A Structural Equation Model, Allyson Blandin

Dissertations

Problem

Academic achievement among the nation’s youth has been on the decline for decades. The statistics from the National Assessment of Educational Progress (NAEP) paints a bleak picture of the academic performance of more than half of the 4th and 8th grade students being below the required levels of proficiency in reading and mathematics. This is evidence that a problem of low academic achievement exists among certain student groups within the public education system. Therefore, it creates an academic achievement gap, which is reflected in the disparity in the standardized scores between students of color from low socio-economic status with …

The Relationship Between Financial Incentives And Perceptions Of Student Choice At Private Michigan Universities, Ndahwa Musa Masanja

Dissertations

Problem

The rising cost of getting a college or university degree gives millions of students “sticker shock” each year, and paying off student debt has only grown more difficult over time (Liberto, 2012). The College Board, a nonprofit group that runs the SAT exam, indicates that over the past decade, the average annual tuition for community college has risen 40% to $3,122 while the yearly cost at a four-year public university has risen 68% to $7,692. The escalating cost of higher education has inevitably influenced students’ choice of college or university (Felton, 2012). These high tuition costs make a college …

Using High-Fidelity Medical Simulation To Assess Critical Thinking In Medical Students, Lynda Daniel-Underwood

Dissertations

Problem

Graduating competent physicians is an imperative societal need. The development of critical thinking skills during medical school is important to meet this societal need and for the care of ill patients. Research shows this skill is key in decreasing medical errors, which in turn decreases cost. (Norman and Eva, 2010) Missing from the literature is a method to assess critical thinking in the setting of caring for the critically ill patient. This instrumental case study tests medical simulation as a method of assessing critical thinking, which incorporates all six competency domains, by looking at the assessment environment, summative patient …

Sex Differences In Stroke Recovery: Synaptic Proteins And The Growth Inhibitory Protein Nogo A, Vincent Joseph Borkowski

Dissertations

Ischemic stroke is a major world-wide health problem, resulting in death and disability especially in the older population. A sex difference exists in functional recovery post-stroke, with post-menopausal women having worse functional outcome as compared to age-matched men. Although the mechanisms underlying this sex difference are not entirely clear, it is recommended that any potential therapy for stroke recovery be tested in pre-clinical models including both male and females in order to determine the efficacy of the proposed treatment on the entire population. We have reported a novel therapy to enhance brain plasticity and improve functional recovery after stroke in …

An Exploration Of Attachment, Trauma, And Treatment Outcome In A Cognative Behaviorable Therapy-Based Group Anger Management Program: A Multiple Case Study, Cynthia K. Swope

Dissertations

This study explored the relationship between trauma, attachment styles, and treatment outcomes among violent offenders attending a group cognitive behavioral therapy (CBT)-based anger management program. Using a mixed method, multiple case study design, the researcher examined the individual experiences of seven individuals court-mandated to attend a community-based anger management program. Semi-structured interviews were utilized to develop the participant narratives used in the qualitative analyses. Participant scores on the Adverse Childhood Experiences (ACE) Questionnaire, the Experience in Close Relationships (ECR-R) Questionnaire, and the Novaco Anger Scale (NAS) provided quantitative measures of trauma history, attachment style, and anger disposition. The results of …

A Framework For Optimizing Data Transfers Between Edge Devices And The Cloud Using Compression Utilities, Armen A. Dzhagaryan

Dissertations

An exponential growth of data traffic that originates on edge devices and a shift toward cloud computing necessitate finding new approaches to optimize file transfers. Whereas compression utilities can improve effective throughput and energy efficiency of file transfers between edge devices and the cloud, finding a best-performing utility for a given file transfer is a challenging task. In this dissertation, we introduce a framework for optimizing file transfers between edge devices and the cloud using compression utilities. The proposed framework involves agents running on edge devices and the cloud that are responsible for selecting an effective transfer mode by considering …

Associative Data Analytics And Its Application To Protein Crystallization Analysis, Imren Dinc

Dissertations

Data analytics focuses on processing raw data to extract important information and involves data acquisition, data analysis, and visualization. To maximize the amount of information obtained, an efficient experimental design method is necessary. Many existing experimental design methods do not consider the previous experimental results when constructing new trial conditions. It is quite difficult to employ supervision in this domain due to limited data size and skewed data distribution. Once the data is collected, proper analysis methods should be developed for making useful decisions regarding the type of data collected (e.g., numerical, time, visual, image analysis). Visualization that encompasses both …

Teachers' Cultural Competence And Students' Perception Of The Social Classroom Climate In Culturally Different Middle School Classrooms, Olivia L. R. Spence

Dissertations

Problem

Teachers and students often come from different cultural backgrounds, so classrooms are increasingly becoming the venue where interactions, if not appropriately managed, will produce a social climate not conducive to learning. The present study seeks to determine to what extent teacher cultural competence impacts student perception of the classroom social environment.

Method

The Teacher Multicultural Attitudes Survey was used to quantify teachers’ cultural competence and a Social Classroom Climate Measure was used to gather scores on the four key factors of the social climate. Hierarchical Linear Modelling was used to assess the influence of teacher cultural competence and several …

Access And Barriers To Care During Transition From Active Duty To Veteran Status In Veterans With Diabetes: A Look At Health Literacy, Change, And Ongoing Diabetes Self-Management Education, Mark R. Malebranche

Dissertations

Background and Rationale: Transition from active duty to veteran status may be a challenging time, especially for veterans with diabetes. These veterans face multiple changes that can cause distress. Most veterans with diabetes have type 2 diabetes, however a diagnosis of type 1 diabetes on active duty is cause for discharge for active duty.

Purposes and Aims: The purpose of this study was to describe the transition experience of veterans diagnosed with diabetes while on active duty from active duty to veteran status. The study describes barriers and facilitators to healthcare and diabetes self-care management. The four aims of the …

In-Hospital Factors Associated With Supplementation Among Healthy, Full-Term, Breastfed Infants, Jodi Kae O'Brien

Dissertations

Background: Formula supplementation of healthy, term, breastfed infants born to mothers who plan to exclusively breastfeed persists at high rates, in spite of global reduction efforts. The identification of modifiable risk factors for supplementation and effective nursing care for successful breastfeeding is understudied.

Purpose: This study aimed to better understand the obstetrical, hospital, and nursing factors associated with supplementation during the hospital stay. The aims were: (1) examine the relationships between aspects of hospital care of infants who are supplemented compared to infants exclusively breastfed and (2) determine what in-hospital risk factors increase the odds of formula supplementation among a …

Who Leads Nonprofit Organizations And What Does It Matter? A Mixed Methods Study Of The Impact Of Different Sector Experience On Nonprofit Leadership, Darrent Robert Tune

Dissertations

The nonprofit sector serves an important economic and community-building role in California and the rest of the United States. However, the nonprofit sector may be facing a leadership deficit due to inadequate succession planning and training of future leaders. Given that nonprofit organizations are often pressured to become more business-like and that many nonprofit organizations may need to adhere to regulations imposed upon them by government funders, nonprofit organizations may be able to find qualified leaders from the for-profit and public sectors.

The purpose of this explanatory sequential mixed methods study was to build on prior research on the sector …