Digital Commons Network^™

Polycystin-2 Is Cardioprotective Against Myocardial Infarction By Regulating The Calcium-Mediated Er-Stress Response, Virdjinija Vuchkovska

Dissertations

Patients with autosomal polycystic kidney disease (ADPKD) have an increased risk and worse outcomes after acute myocardial infarction, but the mechanism for this is unknown. Polycystin 2 (PC2), one of the two main proteins mutated in ADPKD, is a calcium permeant channel that localizes to the ER/SR. In non-cardiac cells, PC2 regulates the unfolded protein response (UPR) pathway under ER stress. However, whether PC2 is cardioprotective against ER stress is unknown. We found that PC2 expression increased in cardiomyocytes from human ischemic hearts and infarcted murine hearts. Cardiomyocyte-specific PC2 KO (PC2 KO) mice had worsened cardiac function after myocardial infarction …

Using Light To Dissect Mechanisms Of Septin Recruitment, Shreya Chandrasekar

Dissertations

Cells interpret biochemical and mechanical signals through dynamic regulation of the cytoskeleton and adhesion complexes, enabling key processes such as shape adaptation, force generation and migration. As these signals vary in both time and space, they can be challenging to resolve using traditional bulk assays. To overcome this limitation, we employ light-based optogenetic tools to reversibly modulate biochemical signals and mechanical equilibrium within cells. Specifically, we use the iLID optogenetic approach to locally activate signaling and manipulate contractility within the cytoskeleton for the purpose of investigating the role of RhoA and contractility on septin organization and adhesion protein localization. We …

Secondary English Language Arts Students’ Perceptions And Attitudes Toward Constructing Multimodal Arguments, Jasenda R. League

Dissertations

The 2025 Georgia English Language Arts standards indicate that teachers will be moving away from a monomodal approach to literacy learning to include students’ construction and evaluation of multimodal texts in grades 9-12. As such, this qualitative case study explored 39 Honors American Literature students' experiences with constructing multimodal arguments. The study sought to understand students’ perceptions and attitudes of creating an argumentative multimodal composition, including their attitudes toward each stage of the composing process: planning, drafting/designing, revising/editing, and publishing. The context was a suburban high school, and the research and data collection took place over 12 weeks. Data types …

Effects Of Exercise Timing On Circadian Rhythm And Functional Outcomes In Cancer Patients Undergoing Treatment, Buck Williams Covington Ii

Dissertations

Poor sleep quality and circadian rhythm disruption are commonly reported among cancer survivors and may contribute to worsened health outcomes, including increased fatigue, psychological distress, and reduced quality of life. While some recent studies suggest that exercise can improve sleep and circadian regulation in cancer survivors, limited research exists on how the timing of this exercise affects these outcomes in cancer survivors. The purpose of this study was to examine the effects of a 12-week supervised exercise intervention, performed either in the morning (AX) or evening (PX), on functional capacity, subjective and objective sleep quality, and peripheral markers of circadian …

Fungal Biodiversity, Microbial Communities, And Ecosystem Function In Non-Perennial Streams, Charles T. Bond

Dissertations

A global majority of steams are non-perennial, drying at some point in time and space. Despite the vital roles that fungi and other microbes play in stream ecosystems, most research on stream microbiomes comes from perennial (continuously flowing) streams. The present series of studies addresses this research gap by examining microbial community composition and function in non-perennial streams, with an emphasis on fungi. Chapter I reviews existing scientific literature on the ecological processes that shape microbiome structure and function in non-perennial streams and outlines the varieties of fungi that may live there. Chapter II uses rDNA metabarcoding to survey fungal …

Finding Utopia: An Examination Of Pedagogical Approaches To Teaching Utopianism In U.S. College Classrooms, Brittany Page Brake

Dissertations

This dissertation investigates how, and if, utopianism is being taught in college classrooms across the United States. Long considered impractical, overly idealistic, and/or politically dangerous, utopianism has been largely marginalized in political science and American culture. However, this project finds that there are instructors teaching utopianism and they are using the concept to challenge students to think differently about governance, justice, and institutional design. Drawing from political theory literature, course syllabi submitted by faculty from different U.S. universities, interviews with instructors, and personal case studies of my own courses at Central State University and Manchester University, I explore how utopian …

Development Of The Hydrogeology Concept Inventory And Exploration Of Its Embedded Spatial Thinking Components, Oluwarotimi Akindele Popoola

Dissertations

Hydrogeology is a sub-discipline of geoscience that deals with the occurrence and movement of water and possible contaminants within the subsurface. Understanding basic principles of hydrogeology is important for applying practical solutions to hydrogeology problems. Hydrogeology is a visuospatial discipline in which spatial thinking skills play a significant role. To assess the hydrogeology knowledge of students, a valid and reliable assessment instrument with spatial components is required.

This research was conducted as a series of quantitative studies with three goals: (1) to develop the Hydrogeology Concept Inventory (HCI), a valid and reliable measure of upper-level undergraduate students’ hydrogeology knowledge, (2) …

Evaluating The Effectiveness Of A Fully Immersive Esol Elementary Program: A Mixed-Methods Study, Equitia D. Armour

Dissertations

With the enrollment of students who are English Language Learners (ELL) steadily rising across the United States, this research sought to understand how immersive models support both language acquisition and academic achievement. This study examined the effectiveness of a fully immersive English Speaker of Other Languages (ESOL) program in one elementary school. The purpose was to identify the qualities of successful ESOL programming, and the conditions needed for sustained growth. The primary research question for this study was: What are the qualities of a successful fully immersive ELL elementary program? Using a mixed-methods design, data were drawn from surveys, interviews, …

The Role Of Sex And Genetic Background In Early Life Stress Effects On Locus Coeruleus Physiology And Related Cognitive And Affective Behaviors, Savannah Grace Brannan

Dissertations

Adverse Childhood Experiences (ACEs) have been associated with many neurodevelopmental and affective disorders, including attention deficit hyperactivity disorder (ADHD) and generalized anxiety disorder (GAD), with more exposures increasing negative risks. Sex and genetic background are biological variables involved in adverse psychiatric outcomes due to ACE exposure(s). Few preclinical studies have properly powered each sex to determine the interaction between sex and genetics on stress-impacting behavior, especially in early life. Females generally have an increased prevalence of stress-related psychopathologies beginning after adolescence, indicative of the adolescent time period as a female-specific sensitive period. To understand the underlying neuronal components responsible for …

Immersive Learning In Action: A Qualitative Case Study Of High School Teachers’ Experiences With Prisms Learning In Science And Mathematics, Hilary A. Cassidy

Dissertations

The use of virtual reality (VR) in the secondary STEM educational space is increasing as costs to access VR technology decrease. There is a current lack of research supporting the efficacy of virtual reality use in the secondary space to improve student success criteria, particularly for specific VR-based instructional products like Prisms. The purpose of this study was to explore the impact of Prisms VR curriculum from the teacher perspective, with specific attention to student engagement, conceptual understanding, and instructional practices. The goal of the study was to contribute to existing research about the paradigm shift toward active student participation …

Using The Time We Have: Exploring Collaborative Instructional Planning For 8th Grade Georgia Studies In A Title I School, Bambara Timmerman

Dissertations

Teacher collaboration in middle schools is often emphasized in educational research and policy, yet content-specific collaboration, specifically for Georgia Studies (GAS), remains underexplored. This participatory qualitative case study explored how middle school GAS teachers perceive the influence of collaborative planning on their self-efficacy, the obstacles they face when attempting to collaborate, and what they perceive would foster a culture that supports ongoing collaborative planning. Grounded in constructivist theory, including social learning theory, situated learning, and social constructivism, this study focused on teachers in a rural Title I middle school. Data collection included demographic questionnaires, interviews, observations, document analysis, and researcher …

Raise Your Digital Hand – Multilingual Learner Student And Teacher Perceptions Of Live Digital Feedback, Naveed Khan

Dissertations

Teachers of Multilingual Learners (MLs) must support students with varying English proficiency as they work toward meaningful academic progress. One promising support is live digital feedback, which can be multimodal—written, typed, drawn, or audiovisual—and serves as an added scaffold as MLs work within their zone of proximal development (ZPD). This qualitative case study examined ML student and teacher perceptions of live teacher and peer digital feedback in one-to-one (1:1) classrooms, grounded in sociocultural theory, effective feedback, and multimodality. The research questions focused on the types of feedback provided by teachers and peers and how ML students—both recipients and peer helpers—and …

Existence, Difference, And The Nigerian Woman: A Feminist Praxis Beyond Patriarchy, Hannah Yemisi Ajewole

Dissertations

This dissertation investigates the postcolonial condition of Nigerian woman through a critical philosophical engagement with feminist theory, focusing particularly on Simone de Beauvoir’s existentialism and Irigaray’s ethics of sexual difference. It interrogates the historical processes through which gender became the basis of hierarchy in the Nigerian society, arguing that colonial and patriarchal override precolonial forms of relationality—marked by dual-sex relationship and age-based hierarchies—into rigid, male-dominated structures of authority and representation. Drawing also on Oyèrónkẹ́ Oyěwùmí’s critique of western gender epistemologies, the work contextualizes the Nigerian woman’s experience within a broader matrix of colonial imposition, cultural displacement, and epistemic violence. This …

Ukrainian Women In The Russo-Ukrainian War: Between Survival And Resistance, Jelena Nikolic Khatatbeh

Dissertations

This dissertation explores how the Russo-Ukrainian war has transformed the lives, identities, and resistance strategies of Ukrainian women. Drawing on in-depth, semi-structured interviews with forty-five Ukrainian women conducted between March 2022 and February 2023, it analyzes how everyday survival, political thought, and civic activism have changed during the war. Using a modified grounded theory approach and a feminist lens, this study examines women’s psychosocial experiences, their evolving political consciousness, and their active roles in humanitarian, cultural, and cyber resistance.Findings reveal that the war simultaneously reinforced and disrupted traditional gender expectations. While Ukrainian women dealt with increased domestic and caregiving burdens …

Motor And Phonic Tic Severity And Its Relationship To Social, Emotional, And School Functioning In Children With Tourette Syndrome From The Caregivers’ Perspective, Courtney C. Thompson

Dissertations

Abstract

Tourette Syndrome (TS) is a neurodevelopmental disorder characterized by motor and phonic tics that is frequently associated with functional impairments. The present study examined the relationship between motor and phonic tic severity, comorbid conditions, academic accommodations, and the social, emotional, and school functioning of children with TS. Caregiver data were collected on tic severity, comorbid conditions, social, emotional, and school functioning, academic accommodations, and grades. Overall, social, emotional, and school functioning fell within the moderate range, with school functioning positively associated with social and emotional functioning. Phonic tics were linked to social functioning, whereas both motor and overall tic …

Environmental Beliefs Among Evangelical Leadership, Jeffrey Stark

Dissertations

There has been consensus among climate scientists for over a decade about the reality of human caused climate change. Even with this consensus, the public understanding of this issue remains divided based on factors generally unrelated to the science. Evangelical Protestants are one group which consistently polls as more skeptical of climate change. This is true not only when compared to the general population but also when compared to other religious demographics. Most large-scale surveys of evangelicals assume the demographic to be a monolith and do not attempt to break the demographic down further. In this mixed methods study, we …

Building Bridges: Co-Producing Philanthropic Public-Private Partnerships For The United States National Park System, Jason S. Northern

Dissertations

The sustainability of America's National Park System increasingly relies on public–private partnerships that leverage private philanthropy. While the National Park Foundation provides national support, local Park Partner nonprofit organizations, like the Gateway Arch Park Foundation, are key to community-level fundraising and advocacy. This qualitative study of the St. Louis Arch grounds renovation examines how this public–private partnership structure influences donor motivation, trust, and engagement. Guided by Social Exchange Theory and Resource Dependency Theory, this research explores the relational and structural dynamics of this philanthropic co-production including reciprocal donor motivations and interdependence among public, private, and nonprofit partners. Fifteen semi-structured interviews …

The Impact Of Teachers' Mathematics Qualifications On Student Proficiency, Riaz H. Zaidi

Dissertations

Schools across the United States face persistent challenges in strengthening mathematics and science education. The present study investigates the relationship between mathematics teachers’ qualifications and their students’ performance on standardized assessments, using data from a Midwestern urban school district’s ACT mathematics scores. Findings are discussed within the broader context of Science, Technology, Engineering, and Mathematics (STEM) education and national efforts to enhance competitiveness among industrialized nations. Despite the presence of leading universities and colleges, U.S. students continue to rank near the middle internationally in math and science achievement, according to the Pew Research Center. Contributing factors include disparities in teacher …

Analyzing Sea Level Rise Scenarios Impact On The Mobility, Infrastructures, Environment Of Abu Dhabi And Defining Solutions By Creating A Digital Twin Using Gis And Game Engine, Justine Sylviane Lucie Sarrau

Dissertations

This dissertation investigates the potential impact of future sea level rise (SLR) scenarios on the city of Abu Dhabi. With climate change, many coastal towns are at risk of experiencing this type of natural hazard. Currently, no precise scenario simulations have been developed, mainly due to the use of low spatial resolution elevation data. Additionally, the difficulty in understanding the real impacts persists when analyses rely solely on traditional cartography and GIS methods. This dissertation aims to advance the field by offering a new approach, which involves creating a comprehensive dynamic 3D simulation with dynamic flowing water. This model, defined …

Analysis Of Antibody Affinity Maturation And Thermal Stability Of Proteins Using Photophysical Approaches, Claire Baxter

Dissertations

Engineered antibodies (Abs) have found applications in disparate fields such as enzyme catalysis and medicinal therapeutics because of their exquisite binding affinity and specificity. To engineer antibodies for these purposes, a firm understanding of the underlying mechanisms that control Ab affinity and specificity is needed, so these properties can be tightly controlled and adapted to the application at hand. My research characterized the binding site of the anti-fluorescein Ab 4-4-20 using an array of biophysical techniques and gives insight into the binding site interactions that give rise to both affinity and specificity. We utilized Fab fragments of the anti-fluorescein Ab …

Philosophical Purification As Liberation And Transformation, Lachanda C. Davis

Dissertations

This study utilizes Plato’s conception of purification as a diagnostic tool to examine contemporary issues of police brutality and political violence. Within this context, I aim to treat the multiple tensions that arise with the question of living a good life. What does it mean to live and what does it mean to live a good life within constraints that magnify fear, anxiety, and despair? I argue that philosophical purification involves ‘aporia’ (perplexity; difficulty; confusion; loss; or puzzlement) in both a literal and generative sense. Moreover, the multiple aporias that arise cannot be reconciled by merely performing a religious rite …

Youth And Parent Knowledge And Perceptions Of Spina Bifida: Associations With Neurocognitive Factors, Self-Management, And Quality Of Life, Olivia Emery Clark

Dissertations

Spina bifida (SB) is a common congenital birth defect with multiple and varied medical, physical, and psychological impacts. The objective of these studies is to examine youth and parent condition-related knowledge in the context of SB and associations with executive function, quality of life, and medical self-management. Collectively, these studies examine both qualitative and quantitative multi-informant data from youth with SB, their parents, and their teachers. The first study used growth analyses to examine changes in condition-related knowledge over time, predicted by executive dysfunction and inattention, and predictive of medical self-management skills. The second study used qualitative coding methods to …

Bodipy-Based Photocages For The Controlled Release Of Hydrogen Sulfide And Persulfides, Yanmei Li

Dissertations

Reactive sulfur species (RSS) such as hydrogen sulfide (H2S) and hydropersulfides (RSSH) are crucial mediators in a variety of physiological and pathological processes. Their regulatory roles span from maintaining cellular redox balance to influencing signaling pathways critical for homeostasis and stress responses. This dissertation investigates H2S and RSSH as biologically important molecules and explores the development of boron-dipyrromethene (BODIPY)-based photocages for its controlled, light-triggered release. Given H2S and RSSH's critical role in redox regulation and cellular protection, achieving spatiotemporal control over its delivery is essential for both therapeutic and research applications. BODIPY scaffolds offer favorable photophysical properties, including visible-light activation …

Reduced Order Models Of Hydrodynamically Interacting Flapping Wings, Jose Pabon

Dissertations

Fish schools exhibit a collective behavior and self-organization that is mediated by hydrodynamic interactions between individual fish. However, the long-time evolution of hydrodynamically interacting collectives is challenging to investigate due to the persistent influence of long-lived vortical structures, and the high-resolution requirements of direct numerical simulation at large Reynolds numbers. Reduced-order models have therefore played an important role in theoretical investigations of collectives of swimming bodies. The main results detailed herein are several new reduced-order models of swimmers that self-propel by flapping, i.e., by executing a prescribed periodic rigid body motion. The models are extensions of a discrete-time dynamical system …

Development And Implementation Of Novel Mass Spectrometric Methods For Metabolism Studies In Drug Discoveries, Huifang Yao

Dissertations

The field of drug discovery has evolved significantly over the past few decades, with a growing emphasis on understanding the metabolic pathways and biotransformation processes that influence the pharmacokinetics and pharmacodynamics of drug candidates. Novel mass spectrometric methods have emerged as powerful tools in this domain, facilitating the comprehensive analysis of metabolic profiles and enabling the identification of metabolites with implications for safety, efficacy, and overall drug development. However, challenges remain in quantifying metabolic flux—an essential aspect of understanding drug action—particularly due to the limitations of traditional isotope kinetic assays, which often involve lengthy sample preparation and the use of …

The Residual Impact Of Slavery On How Enslaved Black Females Defined And Made Meaning Of Sexual Violence: A Content Analysis, Suzanne R. Bates

Dissertations

Thompson-Miller & Picca (2016) and Feimster (2023) argued that enslaved African American women, and even free African Americans after the Civil War were victims of non-consensual sexual activity and rape. The NISVS report revealed that before the age of 18 years old, 35.5% of African American women experienced contact sexual violence, 29.5% experienced non-contact unwanted sexual encounters, and 20.7% experienced rape (Basile et al., 2022). Researchers of slave scholarship have made the case for the importance of including discourse on slavery and enslaved Black females’ experiences when discussing present day sexual violence among Black women in the US today (Balfour, …

The American Politics Of Firearms - The Case Between Illinois And Missouri, Michael J. Thompson

Dissertations

The issue of gun control is a hot topic in the field of American politics. It is a huge issue in the field of political science and in American public policy. In 2023, there were 18,874 firearm deaths in the United States, excluding suicides. The highest was in 2021 with the firearm related deaths at 21,068. One side argues that firearms can cause serious harm and death while the other side argues they can also reduce the rates of gun violence. There are different opinions on how to resolve the issue of mass shootings across the country. According to prior …

Muscarinic Acetylcholine Receptor 1: Implications For Precision Medicine And Rett Syndrome Therapeutics, Mackenzie Smith

Dissertations

Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutations in the gene coding for methyl-CpG binding protein 2 (MeCP2). Currently, there is no cure for RTT and few effective treatment options to address the social, cognitive, motor, and respiratory symptoms that patients face. With the goal of identifying novel targets, our lab performed RNA-sequencing experiments in human autopsy samples and found decreased levels of the M1 muscarinic acetylcholine receptor. We have established that potentiation of this receptor in a Mecp2+/- mouse model of RTT rescues social, cognitive, and respiratory phenotypes, providing support for using drugs that act on …

Biophysical Effects Of Altered Myosin Binding Protein Stoichiometry In Atrial Myofilaments, Kelly N. Araujo

Dissertations

Cardiomyopathies, such as hypertrophic and dilated subtypes, are leading causes of heart failure and are often driven by genetic mutations that disrupt the structure and function of the cardiac sarcomere. While much of the research has focused on ventricular involvement, the role of atrial sarcomere dysfunction remains unexplored. The regulation of contractile function by sarcomeric proteins in the atria remains poorly understood, especially the impact of protein stoichiometry among myosin binding proteins. Cardiac myosin binding protein-C (cMyBP-C) and its atrial paralog, myosin binding protein H-like (MyBP-HL), have been shown to have a stoichiometric relationship within the atrial sarcomere. These two …

Applying Transcriptomics For Technology Development And Conservation In North American Marine Organisms, Cory Von Eiff

Dissertations

RNA biology is a rapidly expanding field, with many avenues of discovery among marine organisms. In this study, we analyze both mollusks and sawfish. First, we perform an evaluation of sRNA biogenesis pathways throughout Mollusca, with emphasis on the easter oyster, Crassostrea virginica. Understanding these molecules prescribes RNAi-based gene silencing approaches, benefiting genetic investigation and biotechnology. Similar to other animal groups, mollusks have conserved microRNAs (miRNAs), with some shared with ecdysozoans and deuterostomes; however, there is no evidence of an endogenous small interfering RNA (siRNA) pathway. These results suggest that long double-stranded RNA (dsRNA)-based RNAi is not appropriate for gene …