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Detection Of Flagellated Protozoa Belonging To The Trypanosomatidae Family In Sand Flies Collected From Songkhla Province, Southern Thailand, Komson Chinwirunsirisup
Detection Of Flagellated Protozoa Belonging To The Trypanosomatidae Family In Sand Flies Collected From Songkhla Province, Southern Thailand, Komson Chinwirunsirisup
Chulalongkorn University Theses and Dissertations (Chula ETD)
Autochthonous leishmaniasis cases in Thailand are increasing dramatically, the disease is caused by two major of Leishmania species; L. orientalis and L. martiniquensis. Leishmaniasis is transmitted to the vertebrate hosts through the bite of the infected female sand fly. Moreover, other trypanosomatid protozoa have also been reported in this insect vector. In 2016, Trypanosoma sp. has been detected in sand fly from Songkhla province, where the leishmaniasis case has been reported. The aims of this study are to investigate the potential vectors of trypanosomatids in this area using morphological and molecular identification based on the Cytb gene. The parasites were …
Effect Of Chronic Paracetamol Treatment On The Alteration Of Learning And Memory In Rats, Laddawan Lalert
Effect Of Chronic Paracetamol Treatment On The Alteration Of Learning And Memory In Rats, Laddawan Lalert
Chulalongkorn University Theses and Dissertations (Chula ETD)
Paracetamol (acetaminophen: APAP) is widely used for treatment of pain and fever. Although APAP is well accepted as a safe drug, several studies have recently demonstrated that treatment with this drug can lead to an alteration of several neurobehaviors. However, the exact impact of the APAP treatment and the mechanisms underlying those effects are still largely unknown. The present study aimed to investigate the effect of APAP treatment on the alteration of learning and memory and the possible mechanism underlying deleterious effects induced by APAP treatment. In this study, APAP at the dose of 200 mg/kg bw was orally fed …
Antilithogenic Efficacy Of An Innovative Beverage Hydrozitla: In Vitro And In Vivo Studies, Nalinthip Lordumrongkiat
Antilithogenic Efficacy Of An Innovative Beverage Hydrozitla: In Vitro And In Vivo Studies, Nalinthip Lordumrongkiat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Urinary stone disease is a common urologic disease worldwide, and it is highly recurrent. Calcium oxalate (CaOx) stone is the most common type of urinary stones. The main causes of urinary stone formation include inadequate water intake, low urinary citrate excretion and increased oxidative stress. At the present day, potassium citrate is a drug of choice for preventing stone formation and recurrence. We developed a new regimen for preventing urinary stone formation, called HydroZitLa. It was in a form of concentrate in pouch. For consumption, water was added up to 500 mL and shake well before drink. Therefore, drinking of …
The Anatomic Variation Of The Superior Peroneal Retinaculum And Inferior Peroneal Retinaculum And Its Association To Peroneal Tendon Disorders, Pimpimol Dangintawat
The Anatomic Variation Of The Superior Peroneal Retinaculum And Inferior Peroneal Retinaculum And Its Association To Peroneal Tendon Disorders, Pimpimol Dangintawat
Chulalongkorn University Theses and Dissertations (Chula ETD)
The precise information for SPR and IPR reattachment is essential for the prevention of recurrent symptom of peroneal tendon dislocation/subluxation. Therefore, this study was conducted to investigate the characteristics, the attachments and morphometric parameters of the SPR, IPR and the prevalence, origin and insertion of the accessory peroneal muscles, peroneal tendon tear, and related structures. The association between the peroneal tendon tear and those structures were evaluated. One hundred and nine embalmed cadaveric legs were dissected in prone position. The SPR was variable in its length, width, angle, thickness, and insertion patterns. Based on the characteristics and insertion pattern, it …
Phosphoproteomic Analysis Of Fc Gamma Receptor Iib Deficient Macrophages In Enhancing The Severity Of Endotoxin Tolerance, Thunnicha Ondee
Phosphoproteomic Analysis Of Fc Gamma Receptor Iib Deficient Macrophages In Enhancing The Severity Of Endotoxin Tolerance, Thunnicha Ondee
Chulalongkorn University Theses and Dissertations (Chula ETD)
Sepsis is a severe response to systemic infection and one of the leading causes of death in patients world-wide. Bacterial endotoxin (lipopolysaccharide; LPS), is a potent inducer of inflammation that has been associated with the pathophysiology of sepsis. The repeated LPS exposure can induce a suppressive effect as refer to endotoxin tolerance. Fc gamma receptor IIb (CD32b), the only inhibitory receptor among FcGR family, associates with systemic lupus erythematosus (FcGRIIb defunctioning polymorphisms) which are commonly found in Asian populations. Because of an inhibitory nature of the signaling, endotoxin tolerance in lupus with FcGRIIb deficient (FcGRIIb-/-) is interesting and might be …
Host And Viral Factors Influencing Disease Progression And Treatment Response In Chronic Hbv Infection, Umaporn Limothai
Host And Viral Factors Influencing Disease Progression And Treatment Response In Chronic Hbv Infection, Umaporn Limothai
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hepatitis B virus (HBV) infection represents a major risk factor of developing chronic hepatitis, cirrhosis and hepatocellular carcinoma (HCC). The clinical outcome of HBV infection depends on complex of host and virus interactions. In this study, we found that serum HBV RNA levels has emerged as a potential viral marker for active HBV infection and may be used to evaluate response to antiviral therapy and disease progression. Serum HBV RNA levels varied among different phases of chronic HBV infection (CHB). There was a correlation between serum HBV RNA levels and amount of intrahepatic covalently closed circular DNA (cccDNA), suggesting that …
The Difference Patterns Of Electrophysiological Properties And Effects Of Kynurenic Acid In Trigeminal Ganglion Neurons Isolated From Rats Migraine Models, Naeemah Haji-A-Sa
The Difference Patterns Of Electrophysiological Properties And Effects Of Kynurenic Acid In Trigeminal Ganglion Neurons Isolated From Rats Migraine Models, Naeemah Haji-A-Sa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Migraine headache generates in trigeminal nociceptive system which is activated by cortical spreading depression (CSD) phenomenon. There are also some neurotransmitter changes relating to pathogenesis of migraine, one of representative examples is serotonin (5-HT) depletion that may predispose to migraine development. Trigeminal ganglion (TG) is a structure containing cell body of neurons that undertakes a role as first order neuron in trigeminal nociceptive system. Moreover, the alteration of glutamate may contribute to hyperactivity of its specific receptors, for instance N-methyl-D-aspartate (NMDA) receptor. Endogenous biomolecule, such as kynurenic acid (KYNA) which is derived form of 5-HT can inhibit NMDA receptor. Basically, …
Anticancer Activity Of Plumbagin On Stem-Like Characteristics, Tumor Angiogenesis And Metastatic Potential In Endocrine Resistant Breast Cancer, Nithidol Sakunrangsit
Anticancer Activity Of Plumbagin On Stem-Like Characteristics, Tumor Angiogenesis And Metastatic Potential In Endocrine Resistant Breast Cancer, Nithidol Sakunrangsit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Plumbagin (PLB), a naphthoquinone compound and vitamin K3 derivative, was shown its potent cytotoxicity and anti-invasion in anti-hormonal resistant cells through the inhibition of Snail-induced epithelial mesenchymal transition (EMT). Overexpression of Snail leads to decrease E-cadherin and increase of beta-catenin, resulting in the activation of Wnt pathway that increases cancer stem-like characteristics in these resistant cells. This study was aimed to investigate the inhibitory effects of PLB on cancer stem-like cells (CSLCs), angiogenesis and Wnt signaling-mediated cell proliferation and invasion. In addition, our study also focused on the anticancer activity of PLB in anti-hormonal resistant breast cancer in vivo. Both …
The Study Of Nerves And Arteries Of Upper Face: Implication For Cosmetic Procedures, Dawinee Chinnawong
The Study Of Nerves And Arteries Of Upper Face: Implication For Cosmetic Procedures, Dawinee Chinnawong
Chulalongkorn University Theses and Dissertations (Chula ETD)
The study of nerves and arteries of upper face for avoiding injury during the forehead lift procedure was conducted to investigate the anatomical landmark and histological plane of the nerve and artery of the upper face for reduce some injuries during a consequence of forehead lift procedure. Thirty adult soft embalmed cadaveric head were dissected. The distances between the frontal branches of the facial nerve and the mid-point of zygomatic arch, lateral canthus and lateral brow were 10.52±2.41, 39.82±7.09 and 24.10±8.92 mm, respectively. The distances between the superficial temporal artery the mid-point of zygomatic arch, lateral canthus and lateral brow …
Does Early Initiation Of Renal Replacement Therapy Have An Impact On 28-Day Mortality In Critically Ill Patients With Acute Kidney Injury With Positive Furosemide Stress Test?: A Multicenter Randomized Controlled Trial, Nuttha Lumlertgul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: The timing of initiation of renal replacement therapy (RRT) in severe acute kidney injury (AKI) remains controversial, with early initiation resulting in unnecessary therapy for some patients while expectant therapy may delay RRT for other patients. The furosemide stress test (FST) has been shown to predict the need for RRT and therefore could be used to exclude low-risk patients from enrollment in trials of RRT timing. Methods: FST was performed using intravenous furosemide (1 mg/kg in furosemide-naive patients or 1.5 mg/kg in previous furosemide users). FST-nonresponsive patients (urine output less than 200 mL in 2 h) were then randomized …
Metabolic Engineering Of Synechococcus Elongatus Pcc 7942 For Mycosporine-2-Glycine Production Under Salt Stress Condition, Panwad Pingkhanont
Metabolic Engineering Of Synechococcus Elongatus Pcc 7942 For Mycosporine-2-Glycine Production Under Salt Stress Condition, Panwad Pingkhanont
Chulalongkorn University Theses and Dissertations (Chula ETD)
ไมโครสปอรีน-ไลก์ อะมิโน แอซิด (MAAs) เป็นกลุ่มของสารเมแทบอไลต์ทุติยภูมิ สังเคราะห์โดยจุลินทรีย์และสาหร่ายหลายชนิด สารกลุ่มนี้มีหน้าที่สำคัญในการคัดกรองรังสียูวี และยังมีหน้าที่อื่นๆ ได้แก่ การต้านอนุมูลอิสระ ปกป้องเซลล์จากภาวะเครียด และควบคุมการออสโมซิส โดยไมโครสปอรีน-2-ไกลซีน (M2G) เป็นหนึ่งในสารกลุ่ม MAAs ที่มีความสามารถในการต้านอนุมูลอิสระมากกว่าสารอื่นๆ ในกลุ่มเดียวกัน ดังนั้นจึงเป็นที่สนใจที่จะเพิ่มการผลิต M2G เพื่อนำไปประยุกต์ใช้ในอุตสาหกรรมความงาม และเวชสำอาง ในการศึกษานี้ประสบความสำเร็จในการแสดงออกของยีนในชีวสังเคราะห์ M2G (Ap3858-3855) จาก Aphanothece halophytica ในไซยาโนแบคทีเรียน้ำจืด Synechococcus elongatus PCC 7942 จากการวิเคราะห์การถอดรหัสของยีน Ap3858-3855 พบว่า ยีนทั้ง 4 ยีนนี้เป็น monocistronic mRNA heterologous expression ของยีน Ap3858-3855 ใน S. elongatus พบว่าทุกยีนมีการแสดงออกมากขึ้นภาวะเครียดจากเกลือ NaCl ยีน Ap3857 แสดงออกเพิ่มมากที่สุด 2.39 ± 0.25 เท่า และภายใต้ภาวะเครียดจากเกลือ KCl ยีน Ap3856 แสดงออกเพิ่มมากที่สุด 3.70 ± 0.35 เท่า ระดับการแสดงออกของยีนที่เกี่ยวข้องกับภาวะเครียดออกซิเดชั่น (sodB, cat และ tpxA) ในเซลล์แสดงออก พบว่าภายใต้ภาวะเครียดจากเกลือ NaCl มีเพียงยีน tpxA แสดงออกมากขึ้น 4.58 ± 0.58 เท่า ขณะที่ภาวะเครียดจากเกลือ KCl กระตุ้นการแสดงออกของ sodB และ tpxA 4.09 ± 0.86 และ 11.81 ± 1.02 เท่า ตามลำดับ ส่วนการแสดงออกของยีนที่เกี่ยวข้องกับสารออสโมไลท์ ได้แก่ Synpcc7942_0808 และ …
Effect Of Chromium Content On Heat Treatment Behavior And Abrasive Wear Resistance Of Multi-Alloyed White Cast Iron, Jatupon Opapaiboon
Effect Of Chromium Content On Heat Treatment Behavior And Abrasive Wear Resistance Of Multi-Alloyed White Cast Iron, Jatupon Opapaiboon
Chulalongkorn University Theses and Dissertations (Chula ETD)
The effect of Cr content on heat treatment behavior and abrasive wear resistance of multi-alloyed white cast irons with basic composition was investigated. The cast irons with varying Cr content from 3-9% were prepared. The annealed specimens were hardened from 1323K and 1373K austenitizing and then, tempered at 673K to 873K with 50K intervals. The microstructure of each specimen consisted of primary austenite dendrite (γP) and (γ+MC) and (γ+M2C) eutectics in specimens with 3 and 5%Cr. By contrast, (γ+M7C3) eutectic appeared in specimens with 6%Cr and more. The matrix in as-cast state was mostly retained austenite but that in as-hardened …
Production Of Monoclonal Antibodies Against Interferon Gamma Of Asian Elephant Elephas Maximus For Tuberculosis Diagnosis In Elephants By Interferon Gamma Release Assay, Songkiat Songthammanuphap
Production Of Monoclonal Antibodies Against Interferon Gamma Of Asian Elephant Elephas Maximus For Tuberculosis Diagnosis In Elephants By Interferon Gamma Release Assay, Songkiat Songthammanuphap
Chulalongkorn University Theses and Dissertations (Chula ETD)
Tuberculosis is a zoonotic disease that can be transmitted from infected animals to humans. Wild animals such as elephants and non-human primate have been reported to be infected by M. tuberculosis (MTB) complex, which can cause tuberculosis in animals as well. The common TB diagnostic approaches in human such as chest X-ray and tuberculin skin test are not practical in the elephants. Moreover, the gold standard of the bacteria culture from trunk wash has low sensitivity, is time-consuming and can only detect tuberculosis in the active stage. Therefore, an accurate diagnosis covering all phases of the MTB infection is in …
Preparation And Characterization Of Nickel Based Nanocomposite Coatings With Enhanced Mechanical And Surface Properties, Malay Kumar Das
Preparation And Characterization Of Nickel Based Nanocomposite Coatings With Enhanced Mechanical And Surface Properties, Malay Kumar Das
Chulalongkorn University Theses and Dissertations (Chula ETD)
Ni-W alloy and Ni-W/diamond monolayer and multilayer composite coatings were prepared by electrodeposition from a Ni-W plating bath with diamond particles suspended into the bath. Ni-W/diamond composite coatings were also prepared with varying amounts of Cobalt sulphate additives. The morphology and the composition of the deposits was investigated by means of SEM and EDS, respectively. The effect of operating conditions and additives on the Ni-W coatings were analyzed. The effect of the plating parameters, composite particle size, multilayer deposits and cobalt additives on microstructure and mechanical properties of the Ni-W/diamond composite coatings was investigated. The electrodeposited Ni-W/diamond deposits reported a …
Preparation Of Graphene Nanocomposites For Anticorrosion And Sensors, Nadtinan Promphet
Preparation Of Graphene Nanocomposites For Anticorrosion And Sensors, Nadtinan Promphet
Chulalongkorn University Theses and Dissertations (Chula ETD)
This dissertation focused on the development of graphene (GO) nanocomposite coating to improve various substrate properties for the sensor application, which is divided into 2 main parts. The first part is the development of GO incorporated into electroless nickel phosphorus (NiP) coating to improve the properties of metal for electrochemical sensor application. Nickel phosphorus - titanium dioxide sol - reduced graphene oxide (NiP-TiO2 sol -RGO) coated surface was successfully prepared by one-pot electroless deposition on the steel substrate. The results show that the homogeneously formation of water-repellent RGO film covering on the coated surface leading to improve the corrosion resistance …
Synthesis Of High Efficiency Amidoxime Polymer Adsorbents For Uranium Extraction From Seawater By Radiation-Induced Polymerization, Wijittra Wongjaikham
Synthesis Of High Efficiency Amidoxime Polymer Adsorbents For Uranium Extraction From Seawater By Radiation-Induced Polymerization, Wijittra Wongjaikham
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study synthesized amidoxime polymer gel for uranium extraction from seawater through a polymerization process with gamma ray or UV-C radiation. The synthesis started with a mixture of acrylonitrile (AN) and methacrylic acid (MAA) monomers together with methylene bisacrylamide as a crosslinker and hydrogen peroxide in the case of UV radiation. The mixture was irradiated with gamma ray at various doses or UV-C for various durations. The resulting polymer gel was ground into fine particles and immersed in a hydroxylamine hydrochloride solution for 90 minutes in order to convert the chemical functional group from the cyano group into the amidoxime …
Predicting Factors Of Preschooler's Parental Feeding Behaviors, Urban Thailand, Chollada Jongsomjitt
Predicting Factors Of Preschooler's Parental Feeding Behaviors, Urban Thailand, Chollada Jongsomjitt
Chulalongkorn University Theses and Dissertations (Chula ETD)
This descriptive correlational study aimed to identify the predicting factors and to examine direct and indirect relationships of preschoolers' parental feeding behaviors (PFB), urban Thailand. The conceptual framework was developed guided by Orem's self-care theory. A Multi-stage sampling was used to recruit 443 parents of preschoolers from 11 schools in Bangkok and city municipalities in all regions of Thailand. Six questionnaires demonstrated acceptable content and construct validity, and reliability were used to ask all participants to complete all questionnaires. Data were collected from November 2018 to May 2019. Most of the participants were mothers (71%). Half of them were aged …
Struggling To Live A New Normal Life Among Chinese Women After Losing The Only Child, Haiyan Wang
Struggling To Live A New Normal Life Among Chinese Women After Losing The Only Child, Haiyan Wang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Losing the only child was a destructive disaster that had destroyed Chinese women's life and health in all dimensions. However, there is no suitable theory or knowledge to guide nursing practice to these women. This study, thus, employed Glaserian grounded theory to discover substantive theory on the living process of Chinese women after losing the only child. Purposive sampling, snowball sampling, and theoretical sampling were used to recruited participants. Thirteen Chinese women who have lost the only child aged 50 to 68 years old recruited. Data were collected through in-depth interview, observation, and field notes. Data were analyzed by the …
Assessment Of Attitudes And Knowledge Of General Dental Practitioners In Providing Implant Maintenance, Aimwalee Rudeejaraswan
Assessment Of Attitudes And Knowledge Of General Dental Practitioners In Providing Implant Maintenance, Aimwalee Rudeejaraswan
Chulalongkorn University Theses and Dissertations (Chula ETD)
This study aimed to survey the attitudes and knowledge of Thai general dental practitioners (GDPs) in proving dental implant maintenance care. The online questionnaire was sent to Thai GDPs who graduated between 2000 and 2016. Of the returned 435 questionnaires, 429 completely filled were included for analysis. 76% of the participants were female and 24% were male. Half of the participants were aged 28-33 years old and 78% of the participants have been working as a GDP 10 years or below. There were 64.3% and 59.4% of the participants who agreed that dental implant surgery and restoration should only be …
Comparison Of The Implant Deviation Between Implants Placed Using Static And Dynamic Computer Assisted Surgery Methods, Dechawat Kaewsiri
Comparison Of The Implant Deviation Between Implants Placed Using Static And Dynamic Computer Assisted Surgery Methods, Dechawat Kaewsiri
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: The aim of this study was to compare the accuracy of implant placement in terms of deviations related to the virtual plan between static and dynamic computer assisted implant surgery (CAIS) systems in single tooth space. Materials & Methods: 60 single implants were randomly placed using two difference CAIS systems by one surgeon. Preoperative CBCT transferred to implant planning software were used to plan the virtual implant position. Implants were placed using either stereolithographic guide template for static CAIS group (n = 30) or implant navigation system for dynamic CAIS group (n = 30). Postoperative CBCT were taken to …
The Development Of Supportive Care Needs Scale For Thai Women With Breast Cancer Undergoing Chemotherapy, Supanee Klungrit
The Development Of Supportive Care Needs Scale For Thai Women With Breast Cancer Undergoing Chemotherapy, Supanee Klungrit
Chulalongkorn University Theses and Dissertations (Chula ETD)
Assessment of supportive care needs before setting up care plans plays significant role in conducting patient-centered care, particularly supportive care needs of Thai women with breast cancer undergoing chemotherapy whose treatment process is specifically different from other group of cancer patients. It was found that supportive care needs scales constructed in western countries had certain limitations of some question items concerning difference in context, ways of life, and culture. Hence they could not assess consistently with all needs of Thai context. This study aims to develop supportive care needs scale for Thai women with breast cancer undergoing chemotherapy with two …
Perceptions, Expectations, And Satisfaction Of Patients Undergoing Dental Implant Therapy In The Faculty Of Dentistry, Chulalongkorn University, Khunsiri Sermsiripoca
Perceptions, Expectations, And Satisfaction Of Patients Undergoing Dental Implant Therapy In The Faculty Of Dentistry, Chulalongkorn University, Khunsiri Sermsiripoca
Chulalongkorn University Theses and Dissertations (Chula ETD)
The aims of this study were to evaluate patient's perception before and after receiving dental implant therapy and to investigate patient's perception, expectation, and satisfaction of dental implant treated by postgraduate dental students and faculty members. This study was designed with a quantitative cross-sectional technique. The data were collected by 3 questionnaires, from patients who intended to receive dental implant treatment during September 2017 to February 2019. Two hundred and fifty participants participated in this study. Most of them were female, aged 55-64 years, graduated bachelor's degree, and facial and teeth appearance did not affect their career. The proportion of …
Comparative Study Of The Accuracy Of Single Tooth Implants Placed Between Static And Mental Computer Assisted Surgery, Palita Smitkarn
Comparative Study Of The Accuracy Of Single Tooth Implants Placed Between Static And Mental Computer Assisted Surgery, Palita Smitkarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: This randomized controlled clinical trial aimed to compared the accuracy of implant position between static and mental Computer Assisted Implant Surgery (CAIS) in single tooth gap. Materials and methods: 52 patients who received 60 implants in single tooth gap, randomized equally into static or mental CAIS. In static CAIS group, data from CBCT scan and data from intraoral or model scan were utilised for the three dimensional virtual planning implant positioning and desiring of a three dimensional surgical guide in implant planning software. Implant bed preparation and implant insertion were done through the three dimensional surgical guide. Implants in …
Comparison Of Single-Dose And Multi-Dose Antibiotic Prophylaxis In Orthognathic Surgery: A Retrospective Cohort Study, Teeraphat Pochana
Comparison Of Single-Dose And Multi-Dose Antibiotic Prophylaxis In Orthognathic Surgery: A Retrospective Cohort Study, Teeraphat Pochana
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objective: (1) to compare the prophylactic effect of a single versus a multiple dose antibiotic regimens and (2) to determine factors related to surgical site infection in orthognathic surgery. Materials and methods: Medical records of patients underwent orthognathic surgery in the Faculty of Dentistry, Chulalongkorn University between 2014 and 2016 were extracted for medical data including demographic data, American Society of Anesthesiologists (ASA)-classified past medical history, orthognathic surgical procedures and complications, prophylactic antibiotic regimen, and surgical site infection. The records also contained 30-day follow-up information, according to the Centers for Disease Control and Prevention (CDC) diagnostic criteria for surgical site …
Comparative Study Between Vitamin B 1-6-12 And Vitamin B 12 For Neurosensory Recovery After Bilateral Sagittal Split Ramus Osteotomy, Worawee Trising
Comparative Study Between Vitamin B 1-6-12 And Vitamin B 12 For Neurosensory Recovery After Bilateral Sagittal Split Ramus Osteotomy, Worawee Trising
Chulalongkorn University Theses and Dissertations (Chula ETD)
A major complication from Bilateral Sagittal Split Ramus Osteotomy (BSSRO) is inferior alveolar nerve injured that manifest as neurosensory disturbance (NSD) on the lower lip, chin. Although the NSD is not a life-threatening problem but it impacts the patient's daily life. Vitamin B is commonly used to treat peripheral neuropathy but it is only few study for NSD from BSSRO. The aim of this study was to evaluate the effect of oral vitamin B1-6-12 and vitamin B12 on NSD after BSSRO. The study design was as a randomized, single blinded control trial of 75 patients who were NSD from BSSRO …
Pd-1 Expression On Immune Cells In Sepsis Mouse Model And The Susceptibility To Secondary Fungal Infection, Chau Tran Bao Vu
Pd-1 Expression On Immune Cells In Sepsis Mouse Model And The Susceptibility To Secondary Fungal Infection, Chau Tran Bao Vu
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: This study aimed to i) determine the kinetic changes of immune cell phenotypes, including an exhaustion marker PD-1, in spleens of murine sepsis ii) investigate the susceptibility against secondary fungal infection after sepsis, and iii) investigate the efficacy of an anti-PD-1 treatment in post-sepsis fungal infection. Methods: Cecal ligation and puncture (CLP) was used as a sepsis model and splenocytes post-CLP were assessed by flow cytometry. In addition, secondary post sepsis systemic fungal infections by Candida albicans or Aspergillus fumigatus administration at 5-day post-CLP were performed. Moreover, secondary aspergillosis was treated with Amphotericin B with or without anti-PD-1 to …
Tlr3 Signaling Modulates Immunomodulatory Property Of Human Periodontal Ligament Stem Cells., Daneeya Chaikiawkeaw
Tlr3 Signaling Modulates Immunomodulatory Property Of Human Periodontal Ligament Stem Cells., Daneeya Chaikiawkeaw
Chulalongkorn University Theses and Dissertations (Chula ETD)
Toll like receptor 3 (TLR3) is a member of TLR family functions to recognizes double-stranded RNA (dsRNA) produced by positive-strand RNA viruses and DNA virusesand generate signaling that stimulate body immune system against virus infection. However, recent evidence suggests that TLR3 signaling may also play a role in initiating the immunosuppressive property of the cells. Study on skin regeneration has shown the anti-inflammatory responses of keratinocytes required for wound healing andthe increasing number of hair follicle formation after TLR3 signaling was activated by fragment of RNA released from damaged cells. Moreover, activation of TLR3 signaling have shown to elicit a …
Effect Of Cyclic Tensile Force On The Expression Of Bone Morphogenetic Protein 9 And Interleukin 6 In Human Periodontal Ligament Cells, Yanee Tantilertanant
Effect Of Cyclic Tensile Force On The Expression Of Bone Morphogenetic Protein 9 And Interleukin 6 In Human Periodontal Ligament Cells, Yanee Tantilertanant
Chulalongkorn University Theses and Dissertations (Chula ETD)
Periodontium is a specialized tissue laying between tooth and surrounding bone. It functions as force cushion. In particular stimulation including mechanical force, periodontal ligament (PDL) cells which are mechanosensitive cells have the ability to secrete specific cytokines and proteins. PDL cells also have the potential to differentiate into osteoblast-like cells or fibroblast-like cells. PDL cells perceive combination of force in oral cavity in which major component is cyclic tensile force (CTF). CTF play an essential role in modulating PDL cells to maintain both hard and soft tissue integrity. Here, we demonstrated that CTF was able to stimulate the expression of …
The Effect Of Disking Technique On Proximal Caries Of Primary Upper Incisors In Tribal Preschool Children Attending Child Development Centers Of Mae Fah Luang District, And Doi Tung Development Project, Chiang Rai, Niwat Thanaboonyang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Aim: To evaluate the effect of disking technique and resin modified glass ionomer cement (RMGI) restoration on proximal caries of primary upper incisors in tribal preschool children, aged 3-5 years, attending child development centers of Doi Tung Development Project, Chiang Rai. Methods: Twenty tribal preschool children were enrolled in this match-paired design study. Twenty-six proximal carious surfaces were randomized for RMGI restoration (control group), and 26 proximal carious surfaces were randomized for disking technique (experimental group). Fluoride varnish was applied in both groups after treatment. At 6-month interval, the treatment success was evaluated including retention of restoration, marginal integrity, no …
Association Between Chronic Periodontitis And Hypertension Among Thai Adults, Ploysiri Rassamee
Association Between Chronic Periodontitis And Hypertension Among Thai Adults, Ploysiri Rassamee
Chulalongkorn University Theses and Dissertations (Chula ETD)
Previous studies suggest that periodontitis may be associated with an increasing risk of hypertension. However, data from large epidemiological studies are limited. The aim of this cross-sectional study was to examine the association between periodontitis and hypertension using data from a cohort study in a Thai population. The study population comprised of 1,378 employees of the Electricity Generating Authority of Thailand (EGAT), aged 53 to 73 years old, were categorized into no/mild, moderate, or severe periodontitis groups. Hypertension was determined as having systolic blood pressure 140 mmHg or more or diastolic blood pressure 90 mmHg or more, or taking antihypertensive …