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Optimized Light Sources For Enhancing Color Discrimination In People With Low Vision, Anukul Radsamrong
Optimized Light Sources For Enhancing Color Discrimination In People With Low Vision, Anukul Radsamrong
Chulalongkorn University Theses and Dissertations (Chula ETD)
This research was divided into 2 parts. The aim of the first part was to investigate if illuminance level and correlated color temperature (CCT) had an effect on mobility performance in people with low vision compared to the elderly wearing simulated low vision glasses and the elderly with naked eyes. We also compared their mobility in pouring liquid to a specified level. The second part’s aim was to optimize combinations of light emitting diode (LED) channels that increased the discrimination of color in people with low vision. The research procedure of the first part involved 7 lighting conditions, with different …
Akt Expression And Lactose Synthesis During Heat Exposure In Saanen Goat, Nungnuch Saipin
Akt Expression And Lactose Synthesis During Heat Exposure In Saanen Goat, Nungnuch Saipin
Chulalongkorn University Theses and Dissertations (Chula ETD)
In tropical countries, high ambient temperature (HTa) is a fundamental factor that cause a decline in the mammary gland function in dairy animals. Dairy animals fed under HTa decreased milk yield (MY) as well as milk compositions. The current study focuses on the effect of HTa to decrease milk synthesis from natural and in vitro HTa condition. The first experiment was performed to investigate the effect of HTa from the natural condition in early lactating Saanen goat, 2-4 weeks of postpartum (2 PP-4 PP). Five animals were investigated during the winter season as control ambient condition. Six animals as the …
Studies Of Beta-Cardiotoxin From King Cobra Venom On Rat Cardiac Functions: Effect On Isolated Single Cardiomyocyte, Tuchakorn Lertwanakarn
Studies Of Beta-Cardiotoxin From King Cobra Venom On Rat Cardiac Functions: Effect On Isolated Single Cardiomyocyte, Tuchakorn Lertwanakarn
Chulalongkorn University Theses and Dissertations (Chula ETD)
Beta-cardiotoxin (ß-CTX), a novel protein isolated from the King cobra (Ophiophagus hannah) venom has previously been proposed as a beta-blocker candidate. However, cellular mechanisms of ß-CTX on cardiomyocyte is unknown. This study aimed to evaluate the impact of ß-CTX on isolated rat cardiomyocyte function and the cardiac myofibrillar activity, and to explore involvement of ß-adrenergic receptor (ß-AR) signaling pathway. ß-CTX was isolated and purified using two-step chromatographic method and confirmed by N-terminal sequencer. The function of ß-CTX on cardiomyocyte was compared to propranolol in 3 conditions, basal state, with isoproterenol (ISO), and with forskolin (FSK). ß-CTX exhibited more potency than …
The Left Ventricular Functions And Heart Rate Variability In Dogs With Pulmonic Valvular Stenosis, Ploypanut Trikhun
The Left Ventricular Functions And Heart Rate Variability In Dogs With Pulmonic Valvular Stenosis, Ploypanut Trikhun
Chulalongkorn University Theses and Dissertations (Chula ETD)
Pulmonic valvular stenosis (PS) is one of the most common congenital heart diseases in dogs that can lead to the cardiac maladaptation. Also, PS can affect the cardiac autonomic nervous system (ANS). However, clinical information regarding to systolic function and cardiac ANS alteration in PS dogs had not been fully elucidated. The objectives of this study were to evaluate cardiac electrical property, left ventricular (LV) function, and to assess cardiac ANS from heart rate variability (HRV) analysis in PS dogs compared with healthy dogs. The dogs in this study were divided into 2 groups, PS dogs (n=13) and healthy control …
Adjustment Of Maximum Likelihood Method For Multivariate Fay-Herriot Model, Annop Angkunsit
Adjustment Of Maximum Likelihood Method For Multivariate Fay-Herriot Model, Annop Angkunsit
Chulalongkorn University Theses and Dissertations (Chula ETD)
The most widely used area-level model in small area estimation is the Fay-Herriot model, proposed by Fay and Herriot. It was used first to estimate average per capita income for small places (population less than 1,000) of the USA. In the context of the Fay-Herriot model, the traditional method in obtaining estimation of the population mean is the empirical best linear unbiased prediction (EBLUP) estimator. The estimate can be expressed as a weighted sum of the direct survey estimator and regression estimator. One problem that has received attention is the estimation of variance of the area random effects in the …
Automatic Model Identification For Time Series Analysis Using Deep Learning, Paisit Khanarsa
Automatic Model Identification For Time Series Analysis Using Deep Learning, Paisit Khanarsa
Chulalongkorn University Theses and Dissertations (Chula ETD)
Most time series data can be characterized by a linear process via the autoregressive integrated moving average model requiring a three-component vector which are the autoregressive, differencing, and moving average orders before fitting coefficients. A model identification which determines those orders is analyzed via the partial autocorrelation function to identify the autoregressive order, the autocorrelation function to identify the moving average order and an extended sample autocorrelation function to identify both orders which is a challenging problem for statisticians. Accordingly, the auto-ARIMA model was proposed to automatically vary those orders and estimates their corresponding coefficients. This thesis proposes three architectures …
Bayesian Models For Poverty Mapping In Thailand, Sarasinee Somjettana
Bayesian Models For Poverty Mapping In Thailand, Sarasinee Somjettana
Chulalongkorn University Theses and Dissertations (Chula ETD)
Poverty maps are important sources of information for solving social, economic, and environmental problems. Initially, the World Bank used the ELL method to produce poverty maps for used in designing, targeting, prioritizing interventions and allocating the budgets for underdeveloped countries. Even though the ELL method has been shown to have many advantages in poverty mapping, it does not use a survey for the most benefit. Therefore, the Empirical Bayes (EB) method and the hierarchical Bayes (HB) method were proposed in literature. In another aspect, Louis shows that the usual Bayes has a limitation. Therefore, he proposed a new method called …
Self-Balancing Recursive Partitioning Algorithm For Classification Problems, Artit Sagoolmuang
Self-Balancing Recursive Partitioning Algorithm For Classification Problems, Artit Sagoolmuang
Chulalongkorn University Theses and Dissertations (Chula ETD)
Creating an effective classification model has been played an important role in knowledge discovery in a database methodology for the past several years. However, there is a critical issue that significantly affects the classification performance appearing in many real-world situations, which is called a class imbalanced problem. In this dissertation, a classification model built based on the recursive partitioning algorithm is improved under the concept of modified entropy components for handling a classification problem regardless of the class imbalanced situation. Three methodologies are introduced for achieving different purposes. The first methodology is presented to classify a binary-class imbalanced dataset dealing …
Stochastic Differential Equation With Jumps For Tilapia Population, Kanitin Sukchum
Stochastic Differential Equation With Jumps For Tilapia Population, Kanitin Sukchum
Chulalongkorn University Theses and Dissertations (Chula ETD)
Tilapia population with harvesting in the tilapia farm can be modeled by an ordinary differential equation (ODE). In real life, tilapia population can be affected by many factors. To make the model for tilapia population more realistic, we develop the ODE into the stochastic differential equation (SDE) together with jumps that represent the epidemic occuring for tilapia. Furthermore, we study the effect of some important parameters in the model to the number of tilapia in the tilapia farm via simulation. Both SDEs for tilapia population with and without jumps are simulated by using Euler-Maruyama and jump-adapted Euler methods.
Integer-Valued Time Series Risk Model With Surrender And Investment, Nuntanut Foosarmpok
Integer-Valued Time Series Risk Model With Surrender And Investment, Nuntanut Foosarmpok
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this study, we construct the discrete-time risk models based on integer-valued time series models by incorporating the concepts of surrender and investment. The surrender considered in this study is the situation that the policyholder decides to exit the policy before maturity date. In our study, we provide the probabilistic properties of the model. Moreover, we derive approximation of ruin probabilities of the constructed risk model. Finally, we discuss the trends of the ruin probability and the value at risk of the model by numerical simulations.
Text Localization And Extraction From Background With Texture And Noise In Digital Images Using Adaptive Thresholding And Convolutional Neural Network, Pukjira Pattaranuprawat
Text Localization And Extraction From Background With Texture And Noise In Digital Images Using Adaptive Thresholding And Convolutional Neural Network, Pukjira Pattaranuprawat
Chulalongkorn University Theses and Dissertations (Chula ETD)
For the past few years, research topics on finding position of text have received more and more attention from researchers because there are still lots of problems that are needed to be solven. We propose a novel method to find the position of text in an image. The first step of the proposed method is to adjust an image by converting a color image to a gray scale image and then use an average filter to improve an image. An average filter is used to make the background smooth and reduce noise. After that an adaptive thresholding is used to …
Iterative Jump To Binding Point For Simplex Method, Rujira Visuthirattanamanee
Iterative Jump To Binding Point For Simplex Method, Rujira Visuthirattanamanee
Chulalongkorn University Theses and Dissertations (Chula ETD)
The basic idea of an iterative jump method is moving a feasible point along the direction that improves the objective value maintaining the feasibility. It is applied for solving a linear programming (LP) model without artificial variables by applying the iterative jump on the LP relaxation having only acute constraints with respect to the objective direction and reinsert all non-acute constraints to find the optimal solution which is named SAJS. However, it may cause the last jump point to locate far away from the optimal solution so another approach for initially finding a suitable starting point is proposed. The new …
First Order Integer-Valued Autoregressive Model With A Two-Parameter Generalized Poisson-Lindley Distribution, Suchiraporn Bunyaris
First Order Integer-Valued Autoregressive Model With A Two-Parameter Generalized Poisson-Lindley Distribution, Suchiraporn Bunyaris
Chulalongkorn University Theses and Dissertations (Chula ETD)
In this study, we introduce the first order integer-valued autoregressive models for count data with the two-parameter generalized Poisson-Lindley distribution. The thinning operators considered in this study are the binomial and negative binomial thinning operators. Some important probabilistic and statistical properties such as moments, stationarity and autocorrelation functions are derived. Moreover, parameter estimations and numerical simulations to examine the constructed model are performed. Finally, applications of the models for real data sets are also discussed.
Graph Representation For Room Layout Matching Using Spectral Embedding, Thamonwan Sa-Ngawong
Graph Representation For Room Layout Matching Using Spectral Embedding, Thamonwan Sa-Ngawong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Graph matching is efficient to search similar layout when the architectural floor plan data size is increasing. Because the computational time of floor plan matching using spectral embedding is only in seconds, so it is one of the popular methods. However, the isomorphism of each floor plan leads to low accuracy in the matching process and it becomes the weakness of this method. Therefore, we propose a graph representation for room layout matching using spectral embedding. Normally, graph representations of the floor plan define nodes as rooms and edges as connections between rooms. Besides, the graph spectral embedding is to …
Architectural Joinery Design To Prevent Water Leakage In A Precast Concrete Detached House, Prokchol Vataniyobol
Architectural Joinery Design To Prevent Water Leakage In A Precast Concrete Detached House, Prokchol Vataniyobol
Chulalongkorn University Theses and Dissertations (Chula ETD)
The precast concrete construction is widely used in Thailand by customers and developers for residential development. For many decades of building with the precast concrete wall system, the common problems of water leakage are the most pressing concerns. This thesis aims to find the issues that lead to the causes of water penetration and propose a solution to prevent water leakage. From the literature review, the sources of water leakage are at the connection location between the precast modules. The water can penetrate through the opening with the four forces: a momentum of the raindrop, capillary action, gravity, and air …
Co-Expression Of Feedback Resistant Enzymes In Phenylalanine Biosynthesis Pathway To Increase Phenylalanine Production, Charintip Yenyuvadee
Co-Expression Of Feedback Resistant Enzymes In Phenylalanine Biosynthesis Pathway To Increase Phenylalanine Production, Charintip Yenyuvadee
Chulalongkorn University Theses and Dissertations (Chula ETD)
L-Phenylalanine (L-Phe) is an important commercial amino acid. It is widely used in food and pharmaceutical industries. Currently, the requirement of L-Phe is increased according to the great demand for the low-calorie sweetener, aspartame. In Escherichia coli, the synthesis of L-Phe is controlled by the multi-hierarchical regulations. AroG isoform of 3-deoxy- D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase) and chorismate mutase/prephenate dehydratase (PheA), two important enzymes, are feedback inhibited by LPhe. Co-expression of feedback-resistant pheA (pheA[superscript L359D]) with other pivotal genes in L-Phe biosynthesis pathway: aroB, aroL, phedh, tktA, aroG, pheA, yddG, and glpF in pRSFDuet-1 (pPTFBLYA[superscript L359D]) elevated L-Phe production of E. …
Functional Characterization Of Cytosolic Ddx41 Sensor In Mediating Antiviral Immune Response In Black Tiger Shrimp Penaeus Monodon, Suthinee Soponpong
Functional Characterization Of Cytosolic Ddx41 Sensor In Mediating Antiviral Immune Response In Black Tiger Shrimp Penaeus Monodon, Suthinee Soponpong
Chulalongkorn University Theses and Dissertations (Chula ETD)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (DDX41), a receptor belonging to the DExD family, was recently identified as an intracellular DNA sensor in vertebrates. Here, we investigated the presence of cytosolic DNA sensing, DDX41 in shrimp Penaeus monodon. By searching for gene involved in DNA sensing cascade within the shrimp P. monodon EST database, 3 cDNA fragments exhibited similarity to DDX41 in various species were identified. Sequences assembly resulted in a complete ORF of Penaeus monodon DDX41 (PmDDX41) which has 1868-bp encoding a putative protein of 620 amino acid residues. The multiple sequence alignment of deduced amino acid sequence of PmDDX41 …
Serial Cultural Heritage Concept, Values Identification, And Management : Case Study Angkor - Phimai Cultural Route, Saowalux Poshyanandana
Serial Cultural Heritage Concept, Values Identification, And Management : Case Study Angkor - Phimai Cultural Route, Saowalux Poshyanandana
Chulalongkorn University Theses and Dissertations (Chula ETD)
Serial cultural heritage refers to groups of cultural heritage sites which are formed as series by significant cultural linkage. It is a category of cultural heritage which has played important roles in World Heritage context, however, it has not been given appropriate attention in general context although it prevails in all cultures. This thesis, therefore, investigated into serial cultural heritage and has clarified its identification, concept, applications, categorization, values identification, and management, both in World Heritage and general contexts, which can be used as initiative frameworks for future works and studies in the issue of serial cultural heritage. To summarize, …
Fructooligosaccharide Synthesis By Immobilized Inulosucrase From Lactobacillus Reuteri 121 And Improvement Of Product Pattern Using Site-Directed Mutagenesis, Thanapon Charoenwongpaiboon
Fructooligosaccharide Synthesis By Immobilized Inulosucrase From Lactobacillus Reuteri 121 And Improvement Of Product Pattern Using Site-Directed Mutagenesis, Thanapon Charoenwongpaiboon
Chulalongkorn University Theses and Dissertations (Chula ETD)
Inulin-type fructooligosaccharides (IFOS) are well-known prebiotics which can be produced from sucrose using bacterial inulosucrase (E.C. 2.4.1.9). However, the use of inulosucrase for IFOS synthesis has some limitations because it also synthesizes some polysaccharides and exhibits lower stability than the fungal enzymes. To overcome these limitations, improvement of inulosucrase was made by using enzyme immobilization and enzyme engineering. First, inulosucrase from Lactobacillus reuteri 121 was immobilized on a novel, high capacity core-shell chitosan beads using glutaraldehyde as a cross-linker. The results showed that both immobilized and free inulosucrase had the same optimum pH (5.5), while the optimum temperature was shifted …
Reproductive And Developmental Biology Of Rice Field Crab Esanthelphusa Nani (Naiyanetr, 1984), Rachata Maneein
Reproductive And Developmental Biology Of Rice Field Crab Esanthelphusa Nani (Naiyanetr, 1984), Rachata Maneein
Chulalongkorn University Theses and Dissertations (Chula ETD)
The rice field crabs are freshwater crabs that can be considered as pest in paddy field as well as a stable food source by local people. Either of these roles requires a good knowledge of its reproductive biology to manage population in nature. In this study, reproductive and endocrine cycles of male and female, and development of embryo were examined. Adult Esanthelphusa nani were field caught from Nan province during November 2015 to November 2016. Crabs were euthanized and dissected for reproductive tracts. Accessory organ nearby the mandibular muscle was collected for endocrine activities in male, while hemolymph was collected …
Ecosystem Service Assessment Of Green Roofs In Bangkok, Rattanapan Phoomirat
Ecosystem Service Assessment Of Green Roofs In Bangkok, Rattanapan Phoomirat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Green roofs are constructed ecosystems that can provide four main types of ecosystem services (regulating, provisioning, cultural, and supporting services). However, most green roof studies have focused on the regulating services and each ecosystem service type was usually evaluated separately. Moreover, there is a lack of assessment tool that can provide comparable outputs of total and different ecosystem services on green roofs, resulting in the difficulty to improve ecosystem service provision by green roofs. Therefore, this research aimed to (i) assess four main categories of ecosystem services provided by seven green roofs in Bangkok using direct measurement techniques and a …
Argonaute 4 Promotes Genomic Methylation, Kanwalat Chalertpet
Argonaute 4 Promotes Genomic Methylation, Kanwalat Chalertpet
Chulalongkorn University Theses and Dissertations (Chula ETD)
RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. Similar to genome and epigenome editing with the CRISPR-Cas9 system, RdDM is composed of a regulatory protein and a “guide” RNA (gRNA), which recruits the complex to specific genomic locations containing DNA sequences homologous to the RNA sequence. In humans, we found that Argonaute-4 (AGO4) colocalization has a strong correlation to promoter methylation of AGO4-binding genes. Here, we engineered cell-penetrating tagged oligoarginines (R9) tagged AGO4 (R9-AGO4) or xentry tagged AGO4 (X-AGO4) loaded with single guided-RNA (sgRNA) as a tool to specifically add methylation at genome locations where …
Serum Non-Coding Rna Levels As Potential Diagnostic And Prognostic Markers Of Hepatocellular Carcinoma, Pornpitra Pratedrat
Serum Non-Coding Rna Levels As Potential Diagnostic And Prognostic Markers Of Hepatocellular Carcinoma, Pornpitra Pratedrat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Hepatocellular carcinoma (HCC) is one of the most common type of liver cancers in the world. Most common cause of HCC is viral hepatitis B infection (HBV). That lead to HCC detection at late stage and be difficult for curative treatment. So, biomarkers for HCC are required to detect HCC efficiently. MicroRNAs and long non-coding RNAs (lncRNAs) play a key role in tumorigenesis through many different mechanisms. Moreover, non-coding RNA can be released into body fluid. Hence purpose of this study is to investigate the level of miRNA and lncRNAs in serum as the used as potential biomarkers for HBV-HCC …
Ecosystem Function Assessment And Participatory Modelling For Community Forest Management At Lainan Subdistrict, Wiang Sa District, Nan Province, Wuthiwong Wimolsakcharoen
Ecosystem Function Assessment And Participatory Modelling For Community Forest Management At Lainan Subdistrict, Wiang Sa District, Nan Province, Wuthiwong Wimolsakcharoen
Chulalongkorn University Theses and Dissertations (Chula ETD)
Community forest management (CFM) is one way used to mitigate deforestation and forest degradation which have been occurring for more than half a century, particularly in northern Thailand. The collaboration in CFM, especially at multiple scales (e.g. subdistrict, district, or provincial levels) is essential to improve a forest ecosystem status and avoid forest degradation risks in the future. Recently, integrative and participatory modelling methodologies, specifically the Companion Modelling (ComMod), have been implemented in the context of sustainable common-pool resource management in several regions of the world. However, the application of this approach in CFM across institutional scales has still been …
Role Of Neutrophils In Osteoarthritis And Rheumatoid Arthritis And Their Metabolomics, Dong Zhan
Role Of Neutrophils In Osteoarthritis And Rheumatoid Arthritis And Their Metabolomics, Dong Zhan
Chulalongkorn University Theses and Dissertations (Chula ETD)
Objectives: Fibroblast-like synoviocytes (FLS) plays a function in the development of synovitis in osteoarthritis (OA) and rheumatoid arthritis (RA). Neutrophil-derived microvesicles (NDMV) can protect cartilage and possess anti-inflammatory effects on recipient cells. We investigated the expression of inflammatory cytokines produced by TNFα-stimulated FLS which were pre-treated with NDMV. Methods: FLS isolated from the synovium of patients with OA were characterized by flow cytometry. Neutrophils were isolated from healthy volunteer blood and were characterized by cytospin and flow cytometry. NDMV, generated from TNFα-stimulated neutrophils, were characterized by electron microscopy, nanoparticle tracking analysis and flow cytometry. MicroRNA of NDMV were sequenced by …
The Effect Of 1’ Acetoxychavicol Acetate On Cell Proliferation, Metastasis, And Angiogenesis In Human Endocrine-Resistant Breast Cancer Cells, Nalinee Pradubyat
The Effect Of 1’ Acetoxychavicol Acetate On Cell Proliferation, Metastasis, And Angiogenesis In Human Endocrine-Resistant Breast Cancer Cells, Nalinee Pradubyat
Chulalongkorn University Theses and Dissertations (Chula ETD)
Background: Oestrogen receptor (ER)-positive breast cancer patients have a good prognosis, but 30% of these developed resistance through hyperactivation of PI3K/AKT, ERK1/2, and NFκB, which interconnected with ER signalling. In this study, the effects of 1’ acetoxychavicol acetate (ACA), a plant-metabolite acetate ester compound with an NF-kB inhibitory activity, were investigated in a panel of endocrine-resistant breast cancer cells. Methods: Plant material was purified by chromatographic methods and followed by structural identification using nuclear magnetic resonance and mass spectroscopy. In vitro and in vivo antiproliferative effects of ACA were studied in MCF7/LCC2 and MCF7/LCC9 endocrine-resistant cells using the MTT assay …
Enhanced Propagation Yield Of Influenza Viruses For Vaccine Production Through Cellular Micrornas Regulation, Suthat Saengchoowong
Enhanced Propagation Yield Of Influenza Viruses For Vaccine Production Through Cellular Micrornas Regulation, Suthat Saengchoowong
Chulalongkorn University Theses and Dissertations (Chula ETD)
Annual influenza vaccination aims to prevent influenza virus infection thus reduce the incidence of infection and disease in humans. Nowadays, Madin–Darby canine kidney (MDCK) cell culture-based system has been approved as an alternative for influenza vaccine production. Although cellular microRNAs may play an important role in controlling the replication of viruses, the interaction between human seasonal influenza viruses and host microRNAs has not been investigated in this permissive cell line. The primary objective of this study is to improve the yield of seasonal influenza virus (i.e. vaccine virus) production via manipulation of the host microRNAs. MDCK cells were infected with …
Angiogenic Effect Of Salt-Leached Thai Silk Fibroin Scaffolds With Human Adipose-Derived Stem Cells, Tanapong Watchararot
Angiogenic Effect Of Salt-Leached Thai Silk Fibroin Scaffolds With Human Adipose-Derived Stem Cells, Tanapong Watchararot
Chulalongkorn University Theses and Dissertations (Chula ETD)
Angiogenesis plays important role in tissue regeneration. Biomaterials that allow and promote angiogenesis are thus beneficial. Silk fibroin (SF) scaffolds are good candidates for angiogenesis activation because of the biodegradability, biocompatibility, and interaction of extracellular matrices. Human adipose-derived stem cells (ADSCs) are also promising for tissue regeneration. This study thus aims to investigate the angiogenic potential of SF scaffolds with/without ADSCs on chick chorioallantoic membrane (CAM). Firstly, the SF scaffolds were fabricated with a porosity of 77.34 ± 16.96% and a pore diameter of 513.95 µm. Then, ADSCs were seeded on SF scaffolds (SF-ADSC scaffolds) and placed on CAM on …
Antioxidant And Antibacterial Agents From Parmotrema Dilatatum (Vainio) Hale, Knema Angustifolia (Roxb.) Warb. And Persicaria Odorata Lour, Asshaima Paramita Devi
Antioxidant And Antibacterial Agents From Parmotrema Dilatatum (Vainio) Hale, Knema Angustifolia (Roxb.) Warb. And Persicaria Odorata Lour, Asshaima Paramita Devi
Chulalongkorn University Theses and Dissertations (Chula ETD)
In the search of antioxidant and antibacterial agents, the extracts and isolated compounds from lichen Parmotrema dilatatum, Knema angustifolia full name, Persicaria odorata and Mansonia gagei. were examined. Nine compounds were isolated from lichen P. dilatatum including (E)-2,4-dihydroxy-6-methyl-3-(3-oxobut-1-en-1-yl)benzoate (PD.1), hopane-16ß,22-diol (PD.2), methyl orsellinate (PD.3), methyl haemmatomate (PD.4), methyl ß-orcinolcarboxylate (PD.5), 2-hydroxy-4-methoxy-3,6-dimethylbenzoic acid (PD.6), atranol (PD.7), atranorin (PD.8) and lecanorin (PD.9). The dichloromethane and acetone fractions, and atranol (PD.7) gave excellent activities as antioxidants. While in tyrosinase activity the dichloromethane fraction and atranorin (PD.8) showed the highest inhibition. For α-glucosidase inhibition activity, the methanol fraction and methyl haemmatommate (PD.4) revealed the …
Enhancement Of Biofuel Production In Microalgae By Genetic And Physiological Modification, Napisa Pattharaprachayakul
Enhancement Of Biofuel Production In Microalgae By Genetic And Physiological Modification, Napisa Pattharaprachayakul
Chulalongkorn University Theses and Dissertations (Chula ETD)
Microalgae are photosynthetic microorganisms, which could be used as potential microbial cell factories by directly converting CO2 into valuable bioproducts and biofuels. This study aims to improve the target biofuel feedstocks from the isolated green alga Chlorella sp. and the engineered cyanobacterium Synechococcus elongatus PCC 7942 in terms of the improvement on lipids (as precursors of FAMEs) and terpene (α-farnesene), respectively. The first part is concerned with the enhancement of lipids and the determination of FAMEs and biodiesel properties in Chlorella sp. under the phosphorus (P) limitation (0-50%) alone or in combination with heavy metals (Fe, Co, Pb) supplementation. The …