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Populist Nationalism Threatens Health And Human Rights In The Covid-19 Response, Caitlin R. Williams, Jocelyn Getgen Kestenbaum, Benjamin Mason Meier Dec 2020

Populist Nationalism Threatens Health And Human Rights In The Covid-19 Response, Caitlin R. Williams, Jocelyn Getgen Kestenbaum, Benjamin Mason Meier

Articles

COVID-19 demands international cooperation, yet populist nationalism is resurgent, threatening public health, human rights, and global governance. In responding to the pandemic, populist nationalism and global solidarity represent distinct paths, with enduring consequences for health and human rights.


Feigned Consensus: Usurping The Law In Shaken Baby Syndrome/Abusive Head Trauma Prosecutions, Keith A. Findley, D. Michael Risinger, Patrick D. Barnes, Julie A. Mack, David A. Moran, Barry C. Scheck, Thomas L. Bohan Dec 2020

Feigned Consensus: Usurping The Law In Shaken Baby Syndrome/Abusive Head Trauma Prosecutions, Keith A. Findley, D. Michael Risinger, Patrick D. Barnes, Julie A. Mack, David A. Moran, Barry C. Scheck, Thomas L. Bohan

Articles

Few medico-legal matters have generated as much controversy--both in the medical literature and in the courtroom--as Shaken Baby Syndrome (SBS), now known more broadly as Abusive Head Trauma (AHT). The controversies are of enormous significance in the law because child abuse pediatricians claim, on the basis of a few non-specific medical findings supported by a weak and methodologically flawed research base, to be able to “diagnose” child abuse, and thereby to provide all of the evidence necessary to satisfy all of the legal elements for criminal prosecution (or removal of children from their parents). It is a matter, therefore, in …


Taxes As Pandemic Controls, Ashley C. Craig, James R. Hines Jr. Dec 2020

Taxes As Pandemic Controls, Ashley C. Craig, James R. Hines Jr.

Articles

Tax policy can play important roles in limiting the spread of communicable disease and in managing the economic fallout of a pandemic. Taxes on business activities that bring workers or customers into close contact with each other offer efficient alternatives to broad regulatory measures, such as shutdowns, that have been effective but enormously costly. Corrective taxation also helps raise the revenue required to cover elevated government expenditure during a pandemic. Moreover, the restricted consumer choice that accompanies a pandemic reduces the welfare cost of raising tax revenue from higher-income taxpayers, making it a good time for deficit closure. Current U.S. …


Neurophysiological Correlates Of Dual Tasking In People With Parkinson's Disease And Freezing Of Gait, Conor Fearon, John Butler, Saskia Waechter, Isabelle Killane, Simon Kelly, Richard B Reilly, Timothy Lynch Dec 2020

Neurophysiological Correlates Of Dual Tasking In People With Parkinson's Disease And Freezing Of Gait, Conor Fearon, John Butler, Saskia Waechter, Isabelle Killane, Simon Kelly, Richard B Reilly, Timothy Lynch

Articles

Freezing of gait in people with Parkinson's disease (PwP) is associated with executive dysfunction and motor preparation deficits. We have recently shown that electrophysiological markers of motor preparation, rather than decision-making, differentiate PwP with freezing of gait (FOG +) and without (FOG -) while sitting. To examine the effect of locomotion on these results, we measured behavioural and electrophysiological responses in PwP with and without FOG during a target response time task while sitting (single-task) and stepping-in-place (dual-task). Behavioural and electroencephalographic data were acquired from 18 PwP (eight FOG +) and seven young controls performing the task while sitting and …


The Life And Death Of Confederate Monuments, Jessica Owley, Jess Phelps Dec 2020

The Life And Death Of Confederate Monuments, Jessica Owley, Jess Phelps

Articles

Confederate monuments have again received increased attention in the aftermath of George Floyd's tragic death in Minneapolis, Minnesota, on May 25, 2020. Momentum and shifting public opinion are working toward the removal of these problematic monuments across the country. This Article seeks to provide insight for monument-removal advocates: specifically focusing on the legal issues associated with the "death" or removal of these monuments, how property law shapes and defines these efforts, and briefly examining what happens to these statues after removal. Our exploration of Confederate monuments reveals that some removal efforts occur outside of legally created processes. Both public and …


Lightgwas: A Novel Machine Learning Procedure For Genome-Wide Association Study, Ambrozio Bruno, Luca Longo, Lucas Rizzo Dec 2020

Lightgwas: A Novel Machine Learning Procedure For Genome-Wide Association Study, Ambrozio Bruno, Luca Longo, Lucas Rizzo

Articles

This paper proposes a novel machine learning procedure for genome-wide association study (GWAS), named LightGWAS. It is based on the LightGBM framework, in addition to being a single, resilient, autonomous and scalable solution to address common limitations of GWAS implementations found in the literature. These include reliance on massive manual quality control steps and specific GWAS methods for each type of dataset morphology and size. Through this research, LightGWAS has been contrasted against PLINK2, one of the current state-of-the-art for GWAS implementations based on general linear model with support to firth regularisation. The mean differences measured upon standard classification metrics, …


A Comparative Analysis Of Rule-Based, Model-Agnostic Methods For Explainable Artificial Intelligence, Giulia Vilone, Lucas Rizzo, Luca Longo Dec 2020

A Comparative Analysis Of Rule-Based, Model-Agnostic Methods For Explainable Artificial Intelligence, Giulia Vilone, Lucas Rizzo, Luca Longo

Articles

The ultimate goal of Explainable Artificial Intelligence is to build models that possess both high accuracy and degree of explainability. Understanding the inferences of such models can be seen as a process that discloses the relationships between their input and output. These relationships can be represented as a set of inference rules which are usually not explicit within a model. Scholars have proposed several methods for extracting rules from data-driven machine-learned models. However, limited work exists on their comparison. This study proposes a novel comparative approach to evaluate and compare the rulesets produced by four post-hoc rule extractors by employing …


Exploring The Potential Of Defeasible Argumentation For Quantitative Inferences In Real-World Contexts: An Assessment Of Computational Trust, Lucas Rizzo, Pierpaolo Dondio, Luca Longo Dec 2020

Exploring The Potential Of Defeasible Argumentation For Quantitative Inferences In Real-World Contexts: An Assessment Of Computational Trust, Lucas Rizzo, Pierpaolo Dondio, Luca Longo

Articles

Argumentation has recently shown appealing properties for inference under uncertainty and conflicting knowledge. However, there is a lack of studies focused on the examination of its capacity of exploiting real-world knowledge bases for performing quantitative, case-by-case inferences. This study performs an analysis of the inferential capacity of a set of argument-based models, designed by a human reasoner, for the problem of trust assessment. Precisely, these models are exploited using data from Wikipedia, and are aimed at inferring the trustworthiness of its editors. A comparison against non-deductive approaches revealed that these models were superior according to values inferred to recognised trustworthy …


Labor Redemption In Work Law, Andrew Elmore Dec 2020

Labor Redemption In Work Law, Andrew Elmore

Articles

People with criminal records are not a protected class under Title VII, and many employers fear that hiring people with criminal records invites negligent hiring liability. Ban the Box privacy laws delay but may not deter overbroad criminal background checks. This Article challenges this standard account by shifting focus to the state in imposing arbitrary barriers to work. I expose a dignity interest in the removal of these unnecessary barriers, or "labor redemption." I find foundations of labor redemption in successful constitutional challenges to denials of public employment and occupational licenses. Labor redemption is also, increasingly, a statutory right, in …


All-Caps, Yonathan A. Arbel, Andrew Toler Dec 2020

All-Caps, Yonathan A. Arbel, Andrew Toler

Articles

A hallmark of consumer contracts is their use of long blocks of capitalized text. These "all-caps" clauses are meant to alert consumers to nonstandard, risky, or important aspects of the transaction that would otherwise be hidden in the fine print. Based on a belief in the power of all-caps, courts will often deny enforcement of many key terms-such as war­ranty disclaimers, liability releases, arbitration clauses, and automatic billing-unless they are presented in all-caps. This article is the first to empirically examine the effectiveness of all-caps. Using an experimental methodology, the article finds that all-caps fail to apprecia­bly improve consent. Moreover, …


Coca-Cola: A Decisive Irs Transferpricing Victory, At Last, Reuven S. Avi-Yonah, Gianluca Mazzoni Dec 2020

Coca-Cola: A Decisive Irs Transferpricing Victory, At Last, Reuven S. Avi-Yonah, Gianluca Mazzoni

Articles

In this article, Avi-Yonah and Mazzoni examine the Tax Court’s decision in Coca-Cola, the first decisive IRS victory in a major transfer pricing case since 1979.


Stereotactic Radiosurgery For Hemorrhagic Symptomatic Cerebral Cavernous Malformations: An International Multicenter Study, Hideyuki Kano, Rachel Jacobs, Huai-Che Yang, Cheng-Chia "Justin" Lee, Ahmed Nabeel, Khaled Abdelkarim, Reem Emad, Amr El-Shehaby, Wael Reda, Sameh Tawadros, Piettar Khalil, Roman Liscak, Khumar Guseynova, Charles Touchette, David Mathieu, Lydia Ren, Jason P Sheehan, Nasser Mohammed, Herwin Speckter, Muayad Almahariq, Inga Grills, Caleb E Feliciano, Rafael Rodriguez-Mercado, L Dade Lunsford Dec 2020

Stereotactic Radiosurgery For Hemorrhagic Symptomatic Cerebral Cavernous Malformations: An International Multicenter Study, Hideyuki Kano, Rachel Jacobs, Huai-Che Yang, Cheng-Chia "Justin" Lee, Ahmed Nabeel, Khaled Abdelkarim, Reem Emad, Amr El-Shehaby, Wael Reda, Sameh Tawadros, Piettar Khalil, Roman Liscak, Khumar Guseynova, Charles Touchette, David Mathieu, Lydia Ren, Jason P Sheehan, Nasser Mohammed, Herwin Speckter, Muayad Almahariq, Inga Grills, Caleb E Feliciano, Rafael Rodriguez-Mercado, L Dade Lunsford

Articles

INTRODUCTION: Stereotactic radiosurgery has been used for treating cavernous malformation. METHODS: Between 1988 and 2018, Gamma KnifeR SRS was performed in 762 evaluable patients with symptomatic CCMs There were 262 (34%) CCM in the brainstem, 148 (19%) in basal ganglia or thalamus, and 372 (49%) in lobar locations. Most patients had experienced 2 or more hemorrhages associated with new neurological deficits. The median CM volume was 1.2 cm3 (range, 0.01-28.9), and the median margin dose was 14.0 Gy. RESULTS: After SRS, 158 patients (21%) had an imaging confirmed new hemorrhage at a median follow-up of 49 months. The hemorrhagefree survival …


Recording Of Endoscopy And Fluoroscopy Of The Vocal Tract With Sound (Or Its Absence): A Disappointment, Robert J Shprintzen, Pablo Antonio Ysunza Nov 2020

Recording Of Endoscopy And Fluoroscopy Of The Vocal Tract With Sound (Or Its Absence): A Disappointment, Robert J Shprintzen, Pablo Antonio Ysunza

Articles

There is an old say: “The devil knows more for being old than for being the devil”. One of the advantages of being old and observing clinical practice and clinical research advance is that successful procedures and methods can be selected and put into practice. Indeed, it is possible to define when practices we thought could be used by our peers simply by being reported in the literature have proven to be doubtful hopes that leave us trying to find out what went wrong. Such is the case with imaging procedures of the vocal tract during speech tasks.


Thermoformed Containers Based On Starch And Starch/Coffee Waste Biochar Composites, Carlos Diaz, Rahul Ketan Shah, Tyler Evans, Thomas A. Trabold, Kathleen Draper Nov 2020

Thermoformed Containers Based On Starch And Starch/Coffee Waste Biochar Composites, Carlos Diaz, Rahul Ketan Shah, Tyler Evans, Thomas A. Trabold, Kathleen Draper

Articles

Biodegradable containers support zero-waste initiatives when alternative end-of-life scenarios are available (e.g., composting, bio digestion). Thermoplastic starch (TPS) has emerged as a readily biodegradable and inexpensive biomaterial that can replace traditional plastics in applications such as food service ware and packaging. This study has two aims. First, demonstrate the thermoformability of starch/polycaprolactone (PCL) as a thermoplastic material with varying starch loadings. Second, incorporate biochar as a sustainable filler that can potentially lower the cost and enhance compostability. Biochar is a stable form of carbon produced by thermochemical conversion of organic biomass, such as food waste, and its incorporation into consumer …


Brightness Matching In Optical See-Through Augmented Reality, Michael Murdoch Nov 2020

Brightness Matching In Optical See-Through Augmented Reality, Michael Murdoch

Articles

A visual experiment using a beam-splitter-based optical see-through augmented reality (OST-AR) setup tested the effect of the size and alignment of AR overlays with a brightness-matching task using physical cubes. Results indicate that more luminance is required whenARoverlays are oversized with respect to the cubes, showing that observers discount theARoverlay to a greater extent when it is more obviously a transparent layer. This is not explained by conventional color appearance modeling but supports an AR-specific model based on foreground-background discounting. The findings and model will help determine parameters for creating convincingARmanipulation of realworld objects.


Association Of Metabolomic Biomarkers With Sleeve Gastrectomy Weight Loss Outcomes, Wendy Miller, Kathryn Ziegler, Stewart Graham, Michael Maddens, Matthew Sims Nov 2020

Association Of Metabolomic Biomarkers With Sleeve Gastrectomy Weight Loss Outcomes, Wendy Miller, Kathryn Ziegler, Stewart Graham, Michael Maddens, Matthew Sims

Articles

Background: Factors influencing weight loss variability following sleeve gastrectomy (SG) are not well understood. We evaluated the correlation of metabolomic biomarkers with weight loss outcomes. Methods: This prospective study evaluated the metabolomic profile of feces and serum prior to SG and three months post-SG, along with weight loss outcomes at three months post-SG (N=45). Serum and fecal samples were quantitatively profiled using a combination of 1H NMR and DI-LC-MS/MS (AbsoluteIDQ P180 kit (Biocrates, Innsbruck)). Results: Percent total weight loss (%TWL) for the lowest versus the highest weight loss tertiles (T1 vs T3) was 11.1 + 0.8% and 17.0 + 1.3%, …


Enhancing The Visibility Of Vernier Effect In A Tri-Microfiber Coupler Fiber Loop Interferometer For Ultrasensitive Refractive Index And Temperature Sensing, Fangfang Wei, Dejun Liu, Zhe Wang, Zhuochen Wang, Gerald Farrell, Qiang Wu, Gang-Ding Peng, Yuliya Semenova Nov 2020

Enhancing The Visibility Of Vernier Effect In A Tri-Microfiber Coupler Fiber Loop Interferometer For Ultrasensitive Refractive Index And Temperature Sensing, Fangfang Wei, Dejun Liu, Zhe Wang, Zhuochen Wang, Gerald Farrell, Qiang Wu, Gang-Ding Peng, Yuliya Semenova

Articles

In this paper a Vernier effect based sensor is analyzed and demonstrated experimentally in a tri-microfiber coupler (Tri-MFC) and polarization-maintaining fiber (PMF) loop interferometer (Tri-MFC-PMF) to provide ultrasensitive refractive index and temperature sensing. The main novelty of this work is an analysis of parameters of the proposed Tri-MFC-PMF with the objective of determining the conditions leading to a strong Vernier effect. It has been identified by simulation that the Vernier effect is a primary factor in the design of Tri-MFC-PMF loop sensing structure for sensitivity enhancement. It is furthermore demonstrated experimentally that enhancing the visibility of the Vernier spectrum in …


Managerial Incentives To Repeatedly Collude: Frequency, Partners And Governance Rules, Catarina Marvao Dr., Chloé Le Coq Nov 2020

Managerial Incentives To Repeatedly Collude: Frequency, Partners And Governance Rules, Catarina Marvao Dr., Chloé Le Coq

Articles

Cartel recidivism has been discovered among many convicted firms and is often perceived as a result of the limited efficiency of competition policy. The incentives for managers to collude have been linked to the firm’s organizational structure, the corporate culture, and the type of executive compensation packages in place.

To the extent that undetected cartels differ from detected ones in relevant dimensions, the current empirical results on illegal cartels are biased. To tackle this issue, we use a novel dataset of a population of cartels, which were legal in Sweden up until 1993. We contribute to the current debate on …


Eventually Periodic Solutions Of Single Neuron Model, Inese Bula, Michael A. Radin Nov 2020

Eventually Periodic Solutions Of Single Neuron Model, Inese Bula, Michael A. Radin

Articles

In this paper, we consider a non-autonomous piecewise linear difference equation that describes a discrete version of a single neuron model with a periodic (period two and period three) internal decay rate. We investigated the periodic behavior of solutions relative to the periodic internal decay rate in our previous papers. Our goal is to prove that this model contains a large quantity of initial conditions that generate eventually periodic solutions. We will show that only periodic solutions and eventually periodic solutions exist in several cases.


A Reference Data Set For Image Registration Of The Pelvis Using Combinatorial Rigid Registration Optimization (Corro)., Afua A Yorke, David Solis Jr, Thoas Guerrero Nov 2020

A Reference Data Set For Image Registration Of The Pelvis Using Combinatorial Rigid Registration Optimization (Corro)., Afua A Yorke, David Solis Jr, Thoas Guerrero

Articles

Purpose Clinical image pairs provide the most realistic test data for image registration evaluation. However, the optimal registration is unknown. Using combinatorial rigid registration optimization (CORRO) we demonstrate a method to estimate the optimal alignment for rigid-registration of clinical image pairs.

Methods Expert selected landmark pairs were selected for each CT/CBCT image pair for six cases representing head and neck, thoracic, and pelvic anatomic regions. Combination subsets of a k number of landmark pairs (k-combination set) were generated without repeat to form a large set of k-combination sets (k-set) for k = 4,8,12. The rigid transformation between the image pairs …


Unwaivable: Public Enforcement Claims And Mandatory Arbitration, Myriam E. Gilles, Gary Friedman Nov 2020

Unwaivable: Public Enforcement Claims And Mandatory Arbitration, Myriam E. Gilles, Gary Friedman

Articles

This essay, written for a conference on the “pathways and hurdles” that lie ahead in consumer litigation, is the first to examine the implications of California’s recent jurisprudence holding public enforcement claims unwaivable in standard-form contracts of adhesion, and the inevitable clash with the U.S. Supreme Court’s decisional law interpreting the Federal Arbitration Act. With its rich history of rebuffing efforts to deprive citizens of public rights through private contract, California provides an ideal laboratory for exploring this escalating conflict.


Safety Of Vitamin D2 Mushroom Powder As A Novel Food Pursuant To Regulation (Eu) 2015/2283, John Kearney, Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw Nov 2020

Safety Of Vitamin D2 Mushroom Powder As A Novel Food Pursuant To Regulation (Eu) 2015/2283, John Kearney, Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw

Articles

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on vitamin D2 mushroom powder as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is an ingredient produced from Agaricus bisporus mushrooms that have been exposed to ultraviolet (UV) light to induce the conversion of provitamin D2 (ergosterol) to vitamin D2 (ergocalciferol). The NF contains concentrations of vitamin D provided by vitamin D2 in the ranges of 1,000–1,300 lg/g. The information provided on the manufacturing process, composition and specifications of the NF …


Incorporating Social Science Into Criminal Defense Practice, Eve Brensike Primus Nov 2020

Incorporating Social Science Into Criminal Defense Practice, Eve Brensike Primus

Articles

In recent decades, social scientists have created a treasure trove of empirical and sociological data that defenders can and should use to help their clients. Evidence rules, criminal law, and criminal procedure are filled with concepts informed by social science. When is evidence likely to unfairly prejudice a defendant in the eyes of a jury? Do police interact differently with members of minority populations and how should that inform concepts of reasonableness? How easy or difficult is it for people to identify individuals they see during high-stress criminal episodes? How effective are police interrogation tactics at getting at the truth …


Quotient-Transitivity And Cyclic Subgroup-Transitivity, Brendan Goldsmith, Ketao Gong Nov 2020

Quotient-Transitivity And Cyclic Subgroup-Transitivity, Brendan Goldsmith, Ketao Gong

Articles

We introduce two new notions of transitivity for Abelian 𝑝-groups based on isomorphism of quotients rather than the classical use of equality of height sequences associated with Abelian 𝑝-group theory. Unlike the classical theory where “most” groups are transitive, these new notions lead to much smaller classes, but even these classes are sufficiently large to be interesting.


Numbers, Patrick Barry Nov 2020

Numbers, Patrick Barry

Articles

Numbers can be numbing. Depend too much on them to make your case, pitch your product, or tell your story, and you risk losing your audience. This essay offers a way to way to use numbers—both large and small—in a manner that is at once more compelling and more concrete.


The Behavioral Effects Of (Unenforceable) Contracts, Evan Starr, Jj Prescott, Norman Bishara Nov 2020

The Behavioral Effects Of (Unenforceable) Contracts, Evan Starr, Jj Prescott, Norman Bishara

Articles

Do contracts influence behavior independent of the law governing their enforceability? We explore this question in the context of employment noncompetes using nationally representative data for 11,500 labor force participants. We show that noncompetes are associated with reductions in employee mobility and changes in the direction of that mobility (i.e., toward noncompetitors) in both states that do and do not enforce noncompetes. Decomposing mobility into job offer generation and acceptance, we detect no evidence of differences in job search, recruitment, or offer activity associated with noncompetes. Rather, we find that employees with noncompetes—even in states that do not enforce them—frequently …


Towards An Urban Disability Agenda, Samuel R. Bagenstos Nov 2020

Towards An Urban Disability Agenda, Samuel R. Bagenstos

Articles

The overwhelming majority of Americans with disabilities live in metropolitan areas. Yet those areas continue to contain significant barriers that keep disabled people from fully participating in city life. Although political and social debate has periodically turned its attention to urban issues or problems — or even the so-called “urban crisis” — during the past several decades, it has too rarely attended to the issues of disability access. When political debate has focused on disability issues, it has tended to address them in a nationally uniform way, without paying attention to the particular concerns of disabled people in cities. Even …


The Executive Branch Anticanon, Deborah Pearlstein Nov 2020

The Executive Branch Anticanon, Deborah Pearlstein

Articles

Donald Trump’s presidency has given rise to a raft of concerns not just about the wisdom of particular policy decisions but also about the prospect that executive actions might have troubling longer term “precedential” effects. While critics tend to leave undefined what “precedent” in this context means, existing constitutional structures provide multiple mechanisms by which presidential practice can influence future executive branch conduct: judicial actors rely on practice as gloss on constitutional meaning, executive branch officials rely on past practice in guiding institutional norms of behavior, and elected officials outside the executive branch and the people themselves draw on past …


A Hybrid Agent-Based And Equation Based Model For The Spread Of Infectious Diseases, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher Oct 2020

A Hybrid Agent-Based And Equation Based Model For The Spread Of Infectious Diseases, Elizabeth Hunter, Brian Mac Namee, John D. Kelleher

Articles

Both agent-based models and equation-based models can be used to model the spread of an infectious disease. Equation-based models have been shown to capture the overall dynamics of a disease outbreak while agent-based models are able to capture heterogeneous characteristics of agents that drive the spread of an outbreak. However, agent-based models are computationally intensive. To capture the advantages of both the equation-based and agent-based models, we create a hybrid model where the disease component of the hybrid model switches between agent-based and equation-based. The switch is determined using the number of agents infected. We first test the model at …


Riluzole Attenuates Glutamatergic Tone And Cognitive Decline In Aβpp/Ps1 Mice., Kevin N Hascup, Caleigh A Findley, Jesse Britz, Nahayo Esperant-Hilaire, Sarah O Broderick, Kristin Delfino, Shelley Tischkau, Andrzej Bartke, Erin R Hascup Oct 2020

Riluzole Attenuates Glutamatergic Tone And Cognitive Decline In Aβpp/Ps1 Mice., Kevin N Hascup, Caleigh A Findley, Jesse Britz, Nahayo Esperant-Hilaire, Sarah O Broderick, Kristin Delfino, Shelley Tischkau, Andrzej Bartke, Erin R Hascup

Articles

We have previously demonstrated hippocampal hyperglutamatergic signaling occurs prior to plaque accumulation in AβPP/PS1 mice. Here, we evaluate 2-Amino-6-(trifluoromethoxy) benzothiazole (riluzole) as an early intervention strategy for Alzheimer's disease (AD), aimed at restoring glutamate neurotransmission prior to substantial Beta amyloid (Aβ) plaque accumulation and cognitive decline. Male AβPP/PS1 mice, a model of progressive cerebral amyloidosis, were treated with riluzole from 2-6 months of age. Morris water maze, in vivo electrochemistry, and immunofluorescence were performed to assess cognition, glutamatergic neurotransmission, and pathology, respectively, at 12 months. Four months of prodromal riluzole treatment in AβPP/PS1 mice resulted in long-lasting procognitive effects and …