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Incoherent Radar Imaging For Breast Cancer Detection And Experimental Validation Against 3d Multimodal Breast Phantoms, Antonio Cuccaro, Angela Dell'aversano, Giuseppe Ruvio, Jacinta Browne, Raffaele Solimene

Articles

: In this paper we consider radar approaches for breast cancer detection. The aim is to give a brief review of the main features of incoherent methods, based on beam-forming and Multiple SIgnal Classification (MUSIC) algorithms, that we have recently developed, and to compare them with classical coherent beam-forming. Those methods have the remarkable advantage of not requiring antenna characterization/compensation, which can be problematic in view of the close (to the breast) proximity set-up usually employed in breast imaging. Moreover, we proceed to an experimental validation of one of the incoherent methods, i.e., the I-MUSIC, using the multimodal breast phantom …

Acute Growth Inhibition & Toxicity Analysis Of Nano-Polystyrene Spheres On Raphidocelis Subcapitata, Anthony Reynolds, Michelle Giltrap, Gordon Chambers

Articles

Micro/nano-plastics (MNPs) have been found within many environments and organisms including humans, making them a significant and growing concern. Initial research into the potential detrimental effects these MNPs both from acute and chronic exposure has been ongoing but still requires substantially more data to clarify. This research presents the response of nano-polystyrene (NPS) on Raphidocelis subcapitata, a freshwater alga, under an existing acute toxicity test along with additional analytical techniques to try identifying possible sources of toxicity. R. subcapitata cells were exposed for 72 h to a concentration range of 0–100 mg/l NPS. Growth Inhibition (GI) testing showed the …

Discrimination Of Immune Cell Activation Using Ramanmicro-Spectroscopy In Anin-Vitro & Ex-Vivo Model, Neha Chaudhary, Thi Nguyet Que Nguyen, Daniel Cullen, Aidan Meade, Claire Wynne

Articles

Activation and proliferation of immune cells such as lymphocytes and monocytes are appropriate inflammatory responses to invading pathogens and are key to overcoming an infection. In contrast, uncontrolled and prolonged activation of these cellular signalling pathways can be deleterious to the body and result in the development of autoimmune conditions. The understanding of cellular activatory status therefore plays a significant role in disease diagnosis and progression. Conventional automated approaches such as enzyme linked immunosorbent assays (ELISA) and immune-labelling techniques are time-consuming and expensive, relying on a commercially available and specific antibody to identify cell activation. Developing a label-free method for …

In Depth Characterisation Of The Biomolecular Coronas Of Polymer Coated Inorganic Nanoparticles With Differential Centrifugal Sedimentation, André Perez-Potti, Hender Lopez, Beatriz Pelaz, Abuelmagd Abdelmonem, Mahmoud G. Soliman, Ingmar Schoen, Philip M. Kelly, Kenneth A. Dawson, Wolfgang J. Parak, Zeljka Krpetic, Marco P. Monopoli

Articles

Advances in nanofabrication methods have enabled the tailoring of new strategies towards the controlled production of nanoparticles with attractive applications in healthcare. In many cases, their characterisation remains a big challenge, particularly for small-sized functional nanoparticles of 5 nm diameter or smaller, where current particle sizing techniques struggle to provide the required sensitivity and accuracy. There is a clear need for the development of new reliable characterisation approaches for the physico-chemical characterisation of nanoparticles with significant accuracy, particularly for the analysis of the particles in the presence of complex biological fluids. Herein, we show that the Differential Centrifugal Sedimentation can …

Optical Fibre Based Real-Time Measurements During An Ldr Prostate Brachytherapy Implant Simulation: Using A 3d Printed Anthropomorphic Phantom, P. Woulfe, Francis John Sullivan, L. Byrne, Andrea Jane Doyle, W. Kam, M. Martin, S. O'Keeffe

Articles

An optical fbre sensor based on radioluminescence, using the scintillation material terbium doped gadolinium oxysulphide (Gd2O2S:Tb) is evaluated, using a 3D printed anthropomorphic phantom for applications in low dose-rate (LDR) prostate brachytherapy. The scintillation material is embedded in a 700 µm diameter cavity within a 1 mm plastic optical fbre that is fxed within a brachytherapy needle. The high spatial resolution dosimeter is used to measure the dose contribution from Iodine-125 (I-125) seeds. Initially, the efects of sterilisation on the sensors (1) repeatability, (2) response as a function of angle, and (3) response as a function of distance, are evaluated …

Evaluation Of Postoperative Refractive Error Correction After Cataract Surgery, Ellen Konadu Antwi-Adjei, Emmanuel Owusu, Emmanuel Kobia-Acquah, Emmanuella Esi Dadzie, Emmanuel Anarfi, Seth Wanye

Articles

Suboptimal cataract surgery outcomes remain a challenge in most developing countries. In Ghana, about 2 million people have been reported to be blind due to cataract with about 20% new cases being recorded yearly. The aim of this study was to evaluate postoperative correction of refractive errors after cataract surgery in a selected eye hospital in Ashanti Region, Ghana. This was a retrospective study where medical records of patients (aged 40–100) who reported to an eye hospital in Ghana from 2013–2018 were reviewed. Included in the study were patients aged ≥40 years and patients with complete records. Data on patient …

Cantilever-Based Sensor Utilizing A Diffractive Optical Element With High Sensitivity To Relative Humidity, Catherine M. Grogan, Faolan Radford Mcgovern, Rory Staines, George Amarandei, Izabela Naydenova

Articles

High-sensitivity and simple, low-cost readout are desirable features for sensors independent of the application area. Micro-cantilever sensors use the deflection induced by the analyte presence to achieve high-sensitivity but possess complex electronic readouts. Current holographic sensors probe the analyte presence by measuring changes in their optical properties, have a simpler low-cost readout, but their sensitivity can be further improved. Here, the two working principles were combined to obtain a new hybrid sensor with enhanced sensitivity. The diffractive element, a holographically patterned thin photopolymer layer, was placed on a polymer (polydimethylsiloxane) layer forming a bi-layer macro-cantilever. The different responses of the …

Raman Spectroscopy Is Sensitive To Biochemical Changes Related To Various Cartilage Injuries, Rubina Shaikh, Ervin Nippolainen, Vesa Virtanen, Jari Torniainen, Lassi Rieppo, Simo Saarakkala, Isaac O. Afara, Juha Töyräs

Articles

Raman spectroscopy is promising in vivo tool in various biomedical applications; moreover, in recent years, its use for characterizing articular cartilage degeneration has been developing. It has also shown potential for scoring the severity of cartilage lesions, which could be useful in determining the optimal treatment strategy during cartilage repair surgery. However, the effect of different cartilage injury types on Raman spectra is unknown. This study aims to investigate the potential of Raman spectroscopy for detecting changes in cartilage due to different injury types. Artificial injuries were induced in cartilage samples using established mechanical and enzymatic approaches to mimic trauma-induced …

Monitoring Stem Cell Differentiation Using Raman Microspectroscopy: Chondrogenic Differentiation, Towards Cartilage Formation, Francesca Ravera, Esen Efeoglu, Hugh Byrne

Articles

Mesenchymal Stem Cells (MSCs) have the ability to differentiate into chondrocytes, the only cellular components of cartilage and are therefore ideal candidates for cartilage and tissue repair technologies. Chondrocytes are surrounded by cartilage-like extracellular matrix (ECM), a complex network rich in glycosaminoglycans, proteoglycans, and collagen, which, together with a multitude of intracellular signalling molecules, trigger the chondrogenesis and allow the chondroprogenitor to acquire the spherical morphology of the chondrocytes. However, although the mechanisms of the differentiation of MSCs have been extensively explored, it has been difficult to provide a holistic picture of the process, in situ. Raman Micro Spectroscopy (RMS) …

The Pure Theory Of Law Is A Hole In The Ozone Layer, Peter Goodrich

Articles

The article critiques the Pure Theory of Law, arguing that it is inadequate and detached from the dynamic and creative aspects of legal practice. The author advocates for a reimagined legal theory that integrates critical perspectives, embodiment, and a connection to the natural world, emphasizing the need for adaptability and responsiveness over static dogma.

Mdl Drano: Rule 23-Based Solutions To Mass Tort Buildup, Myriam E. Gilles, Gary Friedman

Articles

It has been taken as gospel, over the past quarter century, that class action procedures are unavailable in mass tort cases. This Article examines two distinct challenges to that assumption-one resting on Rule 23(c)(4)'s issue class procedure and the other on an innovation advanced by Francis McGovern, in whose honor this Article and symposium are dedicated.

The Issue Class Revolution, Myriam E. Gilles, Gary Friedman

Articles

In 2013, four Supreme Court Justices dissented from the decision in Comcast Corp. v. Behrend, which established heightened requirements for the certification of damages class actions. In a seemingly offhanded footnote, these dissenters observed that district courts could avoid the individualized inquiries that increasingly doom damages classes by certifying a class under Federal Rule of Civil Procedure 23(c)(4) on liability issues only and "leaving individual damages calculations to subsequent proceedings." The dissenters were onto something big. In fact, the issue class and follow-on damages model has broad potential to restore the efficacy of aggregate litigation across several substantive areas …

Stripped Of Funds, Stripped Of Rights: A Critique Of Guardianship As A Remedy For Elder Financial Harm, Rebekah Diller, Leslie Salzman

Articles

There is a growing consensus in the United States and abroad recognizing the right to “legal capacity”—the right to make legally binding decisions for oneself—as a basic human right. Despite this recognition, adult guardianship—the state court procedure by which a person is declared incapacitated and stripped of decision-making rights—remains a widely used tool, particularly for older adults who have suffered financial exploitation or loss. For this population, guardianship is considered an unpleasant yet necessary remedy to address their financial harms. But what if the cure does not really work as intended, while other, less intrusive means could prevent and redress …

Counterterrorism 2.0, Deborah Pearlstein

Articles

Are there any lessons to be gleaned for combatting the rising threat of white nationalist terrorism today from the U.S. response to the attacks of 9/11 twenty years on? This symposium reflection suggests that among the most important lessons may be in avoiding the conceptually defining characteristics of the early U.S. response in 2001. Detainee torture and abuse, the embrace of trial by newly formed military commission, and other misguided policies and practices whose effects are still felt today were set in motion in the first few weeks after the attacks, driven by the instinct to do something, bolstered by …

From The Frying Pan To The Fire: Scotus’ Fsia Inaction As Further Permitting Executive Branch Intervention In “Takings Exception” Cases And Its Consequences In Forcing Holocaust Plaintiffs To Return To Europe, Richard H. Weisberg

Articles

The Supreme Court of the United States (“SCOTUS”) very recently punted and left wide a circuit split on a key question under the Foreign Sovereign Immunities Act (“FSIA”): Do plaintiff Holocaust victims need to return to the country that wronged them in order to proceed in a United States federal court that otherwise had jurisdiction over their claims? While sending down unresolved a conflict between the D.C. and Seventh Circuits, in a companion case also involving Holocaust victims, SCOTUS essentially ended an action against Germany by taking the strong suggestion of the Executive Branch through its Solicitor General that a …

Majestic Law And The Subjective Stop, Kyron J. Huigens

Articles

Justice John Paul Stevens subscribed to "a majestic conception" of the Constitution. This Article articulates and defends that vision. Majestic law and legal reasoning characteristically involve frank moral reasoning, such as one finds in the Eighth Amendment's "evolving standards of decency" test for proportionate punishment, or in Due Process formulations such as an appeal to "immutable principles of justice, which inhere in the very idea of free government." Majestic law employs moral values, norms, and judgments in legal reasoning, taking them on their own terms. Majestic legal reasoning does not weigh revealed preferences for decency, for example. It asks whether …

The Role Of Direct Oral Anticoagulants In Advanced Chronic Kidney Disease–Questions And Future Directions, Filip Ionescu, Saima Mansuri

Articles

With the advent of the direct oral anticoagulants (DOACs), patients requiring anticoagulation for common conditions such as atrial fibrillation and venous thromboembolism no longer need to worry about dietary restrictions or regular monitoring of the international normalized ratio which complicated warfarin treatment. Switching from warfarin to apixaban, a DOAC, has been shown to improve patient satisfaction by reducing treatment burden [1]. The clotting factor Xa inhibitors (apixaban, rivaroxaban, and edoxaban) and the direct thrombin inhibitors (argatroban and dabigatran) have shown non-inferiority in preventing thromboembolic events and a superior safety profile in terms of bleeding and several trials when compared to …

Beware Of Strangers Bearing Gifts, Anthony J. Sebok

Articles

No abstract provided.

Electrodeposition From A Graphene Bath: A Sustainable Copper Composite Alloy In A Graphene Matrix, Hayley Richardson, Charles Bopp, Bao Ha, Reeba Thomas, Kalathur S.V. Santhanam

Articles

The leaching effect of metals has led to the introduction of government regulations for the safety of the environment and humans. This has led to the search for new alloys with long-lasting sustainability. Herein, we wish to report a new brass alloy containing carbon with a remarkable sustainability produced by electrodeposition from a graphene quantum dots bath. The electrochemical measurements were carried out using cyclic voltammetry, potentiodynamic analysis, and Tafel measurements, and the deposits were characterized by X-ray fluorescence spectroscopy (XRF), Raman imaging, X-ray diffraction (XRD), atomic force microscopy (AFM), and scanning electron microscopy (SEM) to understand the surface morphology …

Fluoroscopic Demonstration Of Thoracic Tumor Immobilization With High Frequency Percussive Ventilation, Ina M Sala, Beverly Maurer, Cristian Solano, Ronald Levitin, Thomas M Guerrero

Articles

Purpose: The purpose of this first-in-man study is to directly measure thoracic tumor immobilization by high frequency percussive ventilation (HFPV).

Methods: In an IRB approved protocol (IRB # 2017-046) we screened patients with conspicuous lung tumors that exhibited motion >10 mm to undergo kV fluoroscopy with HFPV. Two sets of consecutive AP (anterior posterior) fluoroscopy frames were acquired during multiple breathing cycles for free- and HFPV- breathing. All images were acquired using our kV source/panel of the therapeutic linear accelerator. Percussions were delivered via the intrapulmonary percussive ventilation device (IPV-2C) and phasitron (Percussionaire Corp., Sagle, Idaho). The baseline settings for …

Data: The Good, The Bad And The Ethical, John D. Kelleher, Filipe Cabral Pinto, Luis M. Cortesao

Articles

It is often the case with new technologies that it is very hard to predict their long-term impacts and as a result, although new technology may be beneficial in the short term, it can still cause problems in the longer term. This is what happened with oil by-products in different areas: the use of plastic as a disposable material did not take into account the hundreds of years necessary for its decomposition and its related long-term environmental damage. Data is said to be the new oil. The message to be conveyed is associated with its intrinsic value. But as in …

Evaluating Instructional Designs With Mental Workload Assessments In University Classrooms, Luca Longo, Giuliano Orru'

Articles

Cognitive cognitive load theory (CLT) has been conceived for improving instructional design practices. Although researched for many years, one open problem is a clear definition of its cognitive load types and their aggregation towards an index of overall cognitive load. In Ergonomics, the situation is different with plenty of research devoted to the development of robust constructs of mental workload (MWL). By drawing a parallel between CLT and MWL, as well as by integrating relevant theories and measurement techniques from these two fields, this paper is aimed at investigating the reliability, validity and sensitivity of three existing self-reporting mental workload …

Mathematical Model Of The Role Of Asymptomatic Infection In Outbreaks Of Some Emerging Pathogens, Nourridine Siewe, Bradford Greening Jr., Nina H. Fefferman

Articles

Preparation for outbreaks of emerging infectious diseases is often predicated on beliefs that we will be able to understand the epidemiological nature of an outbreak early into its inception. However, since many rare emerging diseases exhibit different epidemiological behaviors from outbreak to outbreak, early and accurate estimation of the epidemiological situation may not be straightforward in all cases. Previous studies have proposed considering the role of active asymptomatic infections co-emerging and co-circulating as part of the process of emergence of a novel pathogen. Thus far, consideration of the role of asymptomatic infections in emerging disease dynamics have usually avoided considering …

State Of The Art In Composition, Fabrication, Characterization, And Modeling Methods Of Cement-Based Thermoelectric Materials For Low-Temperature Applications, Xiaoli Liu, Ruchita Jani, Esther Orisakwee, Conrad Johnston, Piotr Chudzinski, Ming Qu, Brian Norton, Niall Holmes Dr., Jorge Kohanoff, Lorenzo Stella, Hongxi Yin, Kazuaki Yazawa

Articles

The worldwide energy crisis and environmental deterioration are probably humanity’s greatest challenges. Thermoelectricity, which allows for the mutual conversion between thermal and electrical energy, has become a promising technology to alleviate this challenge. Increasingly more research focuses on how to fabricate and apply thermoelectric materials for harvesting energy and regulating the indoor thermal environment. However, only a few studies have focused on cementitious materials with thermoelectric potential. Thermoelectric cement is a composite material in which particular additives can enhance the thermoelectric performance of ordinary cement. By potentially replacing traditional construction materials with thermoelectric cement in building applications, electricity could be …

Bio-Binder—Innovative Asphalt Technology, Amir Tabakovic

Articles

The global road network spans 16.3 million km [1], of which 5 million km is in the EU. These road networks fulfil major economic and social goals by facilitating the movement of goods and people throughout the EU, and are therefore of the utmost importance to the economic and social life of the EU [2]. National governments invest heavily in their road networks, e.g., in 2014, EUR 53.33 billion was invested in the development and maintenance of the EU road network [3]. Each year, the world produces 1.6 trillion tonnes of asphalt [4], of which 218 million tonnes is produced …

Do Greenhouse Gases Impact Our Respiratory System? A Study Of The Effect Of Greenhouse Gas Emissions On Respiratory Disease Related Mortality In Ireland, Anushree Priyadarshini, Christina Kenny

Articles

Respiratory-related deaths are one of the major causes of morbidity and mortality every year in the developed world. Previous research outlines that greenhouse gas emission levels have a negative effect on respiratory health and can cause worsening of symptoms. This study examines the impact of greenhouse gas emissions on respiratory disease related mortality in Ireland from 2007-2017 using Statbank data from Central Statistics Office, Ireland. Analysis shows that over the last decade, while greenhouse gases emissions in Ireland have reduced by 1.1%, respiratory disease related mortality has increased on an average by 2.1%. Results indicate that greenhouse gas emis- sions …

A Review Of Bleeding Risk With Impella-Supported High-Risk Percutaneous Coronary Intervention, George W. Vetrovec, Amir Kaki, Thom G. Dahle

Articles

Complex, high-risk percutaneous coronary intervention (HR-PCI) is increasingly being performed, often with mechanical circulatory support (MCS), though to date, there are limited randomised data on the efficacy of MCS for HR-PCI. The majority of MCS is provided by intra-aortic balloon pumps, but increasingly Impella® (Abiomed, Danvers, MA, USA) heart pumps are being used. While the Impella pumps provide greater increases in cardiac output, these devices require large bore access, which has been associated with an increased risk of bleeding and vascular complications. Decisions regarding the use of Impella are often based on risk–benefit considerations, with Impella-related bleeding risk being a …

A Conceptual Model To Explain Dark Matter And Dark Energy, Jonathan Blackledge

Articles

This paper considers a conceptual model that attempts to explain ‘Dark Matter’ and‘Dark Energy’. The model is based on considering a gravitational field to be the result of a mass (aHiggs field) scattering pre-existing cosmic background space-time waves or ‘Uber-waves’. The term‘Uber’ is used to denote an outstanding or supreme example of a particular kind of gravitationalwave with cosmic-scale wavelengths that are far in excess of those associated with the gravitationalwaves generated by accelerating masses. Such waves are taken to be the very lowest frequencycomponents associated with the spectrum of space-time waves generated by the ‘Big Bang’ andare supported by …

On The Generation, Structure, And Semantics Of Grammar Patterns In Source Code Identifiers, Christian D. Newman,, Reem S. Alsuhaibani, Michael J. Decker, Anthony Peruma, Dishant Kaushik, Mohamed Wiem Mkaouer, Emily Hill

Articles

Identifier names are the atoms of program comprehension. Weak identifier names decrease developer productivity and degrade the performance of automated approaches that leverage identifier names in source code analysis; threatening many of the advantages which stand to be gained from advances in artificial intelligence and machine learning. Therefore, it is vital to support developers in naming and renaming identifiers. In this paper, we extend our prior work, which studies the primary method through which names evolve: rename refactorings. In our prior work, we contextualize rename changes by examining commit messages and other refactorings. In this extension, we further consider data …

Covid-19 Reflections On Resilience And Reform In The Child Welfare System, Robert Latham, Kele Stewart

Articles

No abstract provided.