Digital Commons Network^™

Unquantified Benefits And The Problem Of Regulation Under Uncertainty, Jonathan Masur, Eric A. Posner

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No abstract provided.

The Unfinished Business Of Horne V. Department Of Agriculture, Richard A. Epstein

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No abstract provided.

Observation On The Ultrastructure Morphology Of Hela Cells Treated With Ethanol: Statistical Analysis., Fakhri Al-Bagdadi, Matthew J Young, James P Geaghan, Shaomian Yao, Humberto M Barona, Eduardo Martinez-Ceballos, Masami Yoshimura

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It is estimated that 5.9% of all human deaths are attributable to alcohol consumption and that the harmful use of ethanol ranks among the top five risk factors for causing disease, disability, and death worldwide. Ethanol is known to disrupt phospholipid packing and promote membrane hemifusion at lipid bilayers. With the exception of mitochondria involved in hormone synthesis, the sterol content of mitochondrial membranes is low. As membranes that are low in cholesterol have increased membrane fluidity and are the most easily disordered by ethanol, we hypothesize that mitochondria are sensitive targets for ethanol damage. HeLa cells were exposed to …

Synthesis Of Orthogonally Protected Thioamide Dipeptides For Use In Solid-Phase Peptide Synthesis, Fintan Kelleher, Kim Manzor

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Orthogonally protected thioamide-containing dipeptides were efficiently and cleanly prepared from the precursor dipeptides using Curphey’s method (P₄S₁₀, hexamethyldisiloxane (HMDO), reflux, DCM) in 67-96% isolated yield. This was in contrast to the use of Lawesson’s or Berzelius’ reagents where significant issues with reaction non-completion, decomposition and purification were observed. Subsequent clean removal of the dipeptides’ t-butyl ester protecting groups gave thioamide dipeptide acids which were suitable for use in solid-phase peptide synthesis (SPPS).

Recording Of High Efficiency Volume Bragg Gratings In A Photopolymer Using Diffraction From Very Weak Pre-Recorded Gratings, Denis Bade

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No abstract provided.

Supervision Of Students In Social Care Education: Practice Teachers' Views Of Their Role, Fiona Mcsweeney

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This paper presents findings from research about how practice

teachers in social care education in Ireland view their role, in

particular what elements they prioritise and what they see as relatively

unimportant. The aim of the research was exploratory, seeking to

discover commonalities and differences in how practice teachers saw

their role in the supervision of social care students. Q methodology

was used to compare the participants’ viewpoints. Twenty practice

teachers, from varying practice backgrounds and levels of experience,

sorted statements outlining aspects of the practice teacher’s role,

during individual interviews. Analysis indicates participants had two

ways of conceptualising the …

Self-Driving Laws, Anthony Casey, Anthony Niblett

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No abstract provided.

In Memoriam: Abner J. Mikva (1926-2016), Douglas G. Baird

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No abstract provided.

In Memoriam: Abner J. Mikva (1926-2016), David A. Strauss

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No abstract provided.

In Memoriam: Abner J. Mikva (1926-2016), Geoffrey R. Stone

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No abstract provided.

Digital Self-Ownership: A Publicity-Rights Framework For Determining Employee Social Media Rights, Susan Park, Patricia S. Abril

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No abstract provided.

A Comparison Of Three Emerging Online Government 3d Printing Resources: Nasa 3d Resources, Smithsonian X3d, And The Nih 3d Print Exchange, Jennifer J. Horton, Jian Anna Xiong

Articles

United States governmental agencies, departments, and affiliates, are increasingly making 3D printable models available to the general public online. On March 20, 2014, a memorandum was sent out to United States executive departments and agencies about improving access to the government’s scientific collections (Holdren, 2014). This memorandum, from the White House Office of Science and Technology Policy (OSTP), not only addressed physical collections, but specifically mentioned digital 3D models. On the White House’s blog, several reasons were given for making these collections more accessible including the idea that these collections are “… treasure troves of information ripe for exploration and …

Structure-Function Relationships Of Archaeal Cbf5 During In Vivo Rna-Guided Pseudouridylation., Mrinmoyee Majumder, Michael S Bosmeny, Ramesh Gupta

Articles

In Eukarya and Archaea, in addition to protein-only pseudouridine (Ψ) synthases, complexes containing one guide RNA and four proteins can also produce Ψ. Cbf5 protein is the Ψ synthase in the complex. Previously, we showed that Ψ's at positions 1940, 1942, and 2605 of Haloferax volcanii 23S rRNA are absent in a cbf5-deleted strain, and a plasmid-borne copy of cbf5 can rescue the synthesis of these Ψ's. Based on published reports of the structure of archaeal Cbf5 complexed with other proteins and RNAs, we identified several potential residues and structures in H. volcanii Cbf5, which were expected to play important …

The New Labor Law, Kate Andrias

Articles

Labor law is failing. Disfigured by courts, attacked by employers, and rendered inapt by a global and fissured economy, many of labor law’s most ardent proponents have abandoned it altogether. And for good reason: the law that governs collective organization and bargaining among workers has little to offer those it purports to protect. Several scholars have suggested ways to breathe new life into the old regime, yet their proposals do not solve the basic problem. Labor law developed for the New Deal does not provide solutions to today’s inequities. But all hope is not lost. From the remnants of the …

The Second Circuit And Social Justice, Matthew Diller, Alexander A. Reinert

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The Second Circuit is renowned for its landmark rulings in fields such as white collar crime and securities law — bread and butter issues growing out of Wall Street’s preeminence in the financial landscape of the nation. At the same time, the Second Circuit has a long tradition of breaking new ground on issues of social justice. Unlike some circuit courts which have reputations in the area of social justice built around one or two fields, such as the Fifth Circuit’s pioneering role in civil rights litigation or the Ninth Circuit’s focus on immigration, there is no one area of …

An Empirical Study Of Implicit Takings, James E. Krier, Stewart E. Sterk

Articles

Takings scholarship has long focused on the niceties of Supreme Court doctrine, while ignoring the operation of takings law “on the ground” – in the state and lower federal courts, who together decide the vast bulk of all takings cases. This study, based primarily on an empirical analysis of more than 2,000 reported decisions over the period 1979 through June 2012, attempts to fill that void.The study establishes that the Supreme Court’s categorical rules govern almost no cases, and that takings claims based on government regulation almost invariably fail. By contrast, when takings claims arise out of government action other …

Not Too Separate Or Unequal: Marriage Penalty Relief After Obergefell, Mitchell L. Engler, Edward D. Stein

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Joint tax returns have generated controversy for many years. Married couples with the same joint income pay the same tax under our current system regardless of the earnings distribution between the spouses. This approach primarily rests on the idea that married couples share resources and operate as a single economic unit. Critics typically challenge this assumption and lament how marriage might significantly change a couple's taxes. Depending on their earnings breakdown, a couple's taxes could be reduced (a marital bonus for uneven-earners) or increased (a marital penalty for even-earners). These possibilities exist because the joint brackets are typically larger-but not …

An Argument Against Civil Marriage, J. David Bleich

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The article argues against the legal recognition of civil marriage, particularly in the context of same-sex marriage as upheld by the Supreme Court in Obergefell v. Hodges. The author contends that legal recognition of same-sex marriage conflates moral approval with legal neutrality, leading to potential conflicts between individual conscience and state mandates. Drawing on Talmudic principles and historical legal precedents, the article advocates for the abolition of civil marriage and proposes an alternative system of designating "close friends" for legal purposes to avoid such conflicts.

Human Development As An Intellectual Property Metric, J. Janewa Osei-Tutu

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No abstract provided.

Technical Standards And Lawsuits Involving Accommodations For Health Professions Students, Samuel R. Bagenstos

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This article will discuss the legal obligations of medical schools to accommodate applicants and students with disabilities. The article begins by describing the problem of denial of medical education to such students, a problem that results from both discrimination in admissions and denial of accommodations to incumbent students with disabilities. The article then discusses the disability rights legislation that prohibits discrimination against—and requires reasonable accommodation of—qualified medical students with disabilities. It concludes by reviewing a number of lawsuits involving requests for accommodation and how disability rights law was applied in those cases.

An Empirical Study Of Implicit Takings., James E. Krier, Stewart E. Sterk

Articles

Takings scholarship has long focused on the niceties of Supreme Court doctrine, while ignoring the operation of takings law "on the ground" in the state and lower federal courts, which together decide the vast bulk of all takings cases. This study, based primarily on an empirical analysis of more than 2000 reported decisions ovcr the period 1979 through 2012, attempts to fill that void. This study establishes that the Supreme Court's categorical rules govern almost no state takings cases, and that takings claims based on government regulation almost invariably fail. By contrast, when takings claims arise out of government action …

The Sec, Administrative Usurpation, And Insider Trading, Adam C. Pritchard

Articles

The history of insider trading law is a tale of administrative usurpation and legislative acquiescence. Congress has never enacted a prohibition against insider trading, much less defined it. Instead, the SEC has led in defining insider trading, albeit without the formality of rulemaking, and subject to varying degrees of oversight by the courts. The reason why lies in the deference that the Supreme Court gave to the SEC in its formative years. The roots of insider trading law are commonly traced to the SEC’s decision in Cady, Roberts & Co. Cady, Roberts was only made possible, however, by the …

Impediments In The Corporate Social Responsibility (Csr) Space: A Mixed-Method Approach, Tony Kealy

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Despite the potentially positive image and reputation implications of businesses implementing strategies in Corporate Social Responsibility (CSR), there appears to be a dearth of companies willing to play a leading role in moving CSR activities to upper levels within the consciousness of the organisation. The vast majority of businesses are merely complying with national regulations in their business sustainability efforts. This study investigates the reasons why there are road-blocks in the pursuit of higher levels of sustainable business development. A 17-question on-line survey was administered to a number of global participant businesses in a range of industries. The resulting qualitative …

A Fully Integrated Microfluidic Device For Point-Of-Care Monitoring Of Antithrombotics, Leanne F. Harris, Paul Rainey, Tomas L. Lindahl, Anthony J. Killard

Articles

The simplicity and efficiency of point of care diagnostics have revolutionised patient care. Current methods for measuring hypercoagulability often require trained technicians, large blood volumes, and result in long turnaround times. Standard testing for hypercoagulable disorders is performed in the central laboratory using automated coagulation analysers. However the trend is moving towards the development and implementation of point of care testing, as a result of the ever increasing number of patients on antithrombotic therapy. We present a novel microfluidic device and assay for monitoring the effect of two anticoagulants, unfractionated heparin (UFH) and low molecular weight heparin (LMWH). The assay …

Short Term Forecasting Of Nitrogen Dioxide (No2) Levels Using A Hybrid Statistical And Air Mass History Modelling Approach, Aoife Donnelly, Owen Naughton, Brian Broderick, Bruce Misstear

Articles

A novel hybrid model has been developed to support the provision of real-time air quality forecasts. Statistical techniques have been applied in parallel with airmass history modelling to provide an efficient and accurate forecasting system with the ability to identify high NO2 events, which tend to be the episodes ofmost significance in Ireland. Airmass history modelling and k-means clustering are used to identify air mass types that lead to high NO2 levels in Ireland. Trajectory matching techniques allow data associated with these air masses to be partitioned during model development. Non-parametric regression (NPR) has been applied to describe nonlinear variations …

The Economic Boom, Bust And Transport Inequity In Suburban Dublin, Ireland, Sarah Rock, Aoife Ahern, Brian Caulfield

Articles

This paper examines the existence and extent of transport inequity and disadvantage in new suburbs in Dublin, built during the Celtic Tiger period and as experienced during the recession. Findings are presented from a household postal survey from three case study areas built between 2001 and 2008. The case study areas are typical 'middle class' suburbs, and were constructed at a time when Ireland was experiencing unprecedented economic growth. The subsequent recession left many of these areas in significant negative equity, and householders with very limited housing mobility. Results from the survey point to considerable problems that are impacting on …

Lux In Arcana: Decoding The Right To Be Forgotten In Digital Archives, Patricia S. Abril, Eugenio Pizarro Moreno

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On 13 May 2014, the European Court of Justice ruled that search engines such as Google had a duty to respect EU citizens' right to be forgotten. That is, the search engines-deemed "controllers" of information under the Directive-were obligated in some circumstances to remove or de-list links from search results that pertain to information that infringes on an individual's rights under the Directive. In the fall of 2015, the Spanish Supreme Court found itself obligated to determine the application of the digital right to be forgotten in a different context: This time in a digital newspaper archive. However, since …

Bicp Global Bim Study, Barry Mcauley, Alan Hore, Roger West

Articles

The BICP is a direct response to the 2014 Construction 2020 report calling on Enterprise Ireland to work with industry organisations to promote the use of BIM and develop the appropriate technical skills amongst Irish construction firms so that they can successfully compete in markets where BIM is widely adopted or a requirement. There are four distinct work packages to achieve the strategic objectives of the BICP which include amongst other things a systematic review of BIM adoption in international regions, with particular focus on the enablers to support national implementation programmes. This study focused on exploring the value proposition …

From Integrationism To Equal Protection: Tenbroek And The Next 25 Years Of Disability Rights, Samuel R. Bagenstos

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If there is one person who we can say is most responsible for the legal theory of the disability rights movement, that person is Jacobus tenBroek. Professor tenBroek was an influential scholar of disability law, whose writings in the 1960s laid the groundwork for the disability rights laws we have today. He was also an influential disability rights activist. He was one of the founders and the president for more than two decades of the National Federation of the Blind, one of the first-and for many years undisputedly the most effective-of the organizations made up of people with disabilities that …

Microangiopathic Occlusion Of A Perforating Prepontine Long Circumferential Artery Presenting With Lower Motor Neuron Facial Weakness: Clinical And Radiological Correlation, Archie Defillo Md, Muhammad Shah Miran Md, Kenneth Shea Md, Michelle Peterson Np, Leah Roering Np, Jerone Kennedy Md, M. Fareed, K. Suri

Articles

Case Description: A 79-year old male patient with myelodysplastic syndrome associated with severe neutropenia, thrombocytopenia, anemia, hypertension, and hyperlipidemia was admitted for pneumonia secondary to influenza A. Two weeks later he presented with new symptoms of acute dysarthria, and left facial weakness involving his upper and lower face; the following day he developed left arm weakness. Admission computed tomography (CT) and MRI scans revealed an acute ischemic stroke (AIS) in the right posterior frontal cortex. The initial MRI was reported negative for pontine lesions. Anatomically, the cortical infarct could not explain his left lower motor neuron cranial nerve VII (LMN …