Digital Commons Network^™

Projections Of Temperature-Related Excess Mortality Under Climate Change Scenarios, Antonio Gasparrini, Yurning Guo, Francesa Sera, Ana Maria Vicedo-Cabrera, Veronika Huber, Shilu Tong, Micheline De Sousa Zanotti Stagliorio Coelho, Paulo Saldiva, Eric Lavigne, Patricia Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jan Kysely, Ales Urban, Jauni Jaakkola, Niilo Ryti, Mathilde Pascal, Patrick J. Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Yasushi Honda, Magali Hurtado-Diaz, Julio Cruz, Xerxes Seposo, Ho Kim, Aurelio Tobias, Carmen Iniguez, Bertil Forsberg, Daniel Astrom, Martina Ragettli, Yue Guo, Chang-Fu Wu, Antonella Zaobetti, Joel Schwartz, Michelle Bell, Tran Ngoc Dang, Duong Do Van, Clare Heaviside, Sotiris Vardoulakis, Shakoor Hajat, Andy Haines, Ben Armstrong

Articles

Summary Background Climate change can directly affect human health by varying exposure to non-optimal outdoor temperature. However, evidence on this direct impact at a global scale is limited, mainly due to issues in modelling and projecting complex and highly heterogeneous epidemiological relationships across different populations and climates. Methods We collected observed daily time series of mean temperature and mortality counts for all causes or non-external causes only, in periods ranging from Jan 1, 1984, to Dec 31, 2015, from various locations across the globe through the Multi-Country Multi-City Collaborative Research Network. We estimated temperature–mortality relationships through a two-stage time series …

Exploring Smoking, Mental Health And Smoking-Related Disease In A Nationally Representative Sample Of Older Adults In Ireland: A Retrospective Secondary Analysis, Annette Burns, Judith Strawbridge, Luke Clancy, Frank Doyle

Articles

Objective

Smoking is the leading preventable cause of death among individuals with mental health difficulties (MHD). The aim of the current study was to determine the impact of smoking on the physical health of older adults with MHD in Ireland and to explore the extent to which smoking mediated or moderated associations between MHD and smoking-related diseases.

Methods

Cross-sectional analysis of a nationally representative sample of 8175 community-dwelling adults aged 50 and over from The Irish Longitudinal Study on Ageing (TILDA) was undertaken. Multivariate adjusted logistic regression models were used to assess the association between MHD, smoking (current/past/never) and smoking-related …

Maternal Nutrient Intakes From Food And Drinks Consumed In Early Pregnancy In Ireland, Laura Mullaney, Shona Cawley, Rachel Kennedy, Amy C. O'Higgins, Daniel Mccartney, Michael J. Turner

Articles

Background: The aim of this observational study was to measure food, macronutrient and micronutrient intakes of women presenting for antenatal care and assess compliance with current nutritional recommendations.

Determination Of Sphingosine-1-Phosphate In Human Plasma Using Liquid Chromatography Coupled With Q-Tof Mass Spectrometry, Emmanuel Egom, Ross Fitzgerald, Rebecca Canning, Rebabonye B. Pharithi, Colin Murphy, Vincent Maher

Articles

Evidence suggests that high-density lipoprotein (HDL) components distinct from cholesterol, such as sphingosine-1-phosphate (S1P), may account for the anti-atherothrombotic effects attributed to this lipoprotein. The current method for the determination of plasma levels of S1P as well as levels associated with HDL particles is still cumbersome an assay method to be worldwide practical. Recently, a simplified protocol based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the sensitive and specific quantification of plasma levels of S1P with good accuracy has been reported. This work utilized a triple quadrupole (QqQ)-based LC-MS/MS system. Here we adapt that method for the determination of plasma …

Sinapinic And Protocatechuic Acids Found In Rapeseed: Isolation, Characterisation And Potential Benefits For Human Health As Functional Food Ingredients, Leah Quinn, Steven G. Gray, Steve Meaney, Steven Fiinn, Owen Kenny, Maria Hayes

Articles

Rapeseed is a globally valuable crop, and its production has steadily grown over the past 20 yr. Rapeseed is cultivated in China, India, Canada and Europe; however, in terms of rapeseed production, Europe is the largest producer (Carre, 2014). In the year 2013/2014, the European Union (EU) produced 9.93 million t of rapeseed oil, while China produced 6.58 million t (List, 2015). A by-product of the rapeseed oil industry, rapeseed meal contains bioactive constituents, such as the phenolics sinapinic acid (SA) and protocatechuic acid (PCA), which have potential uses as functional food ingredients and for use in cosmetic and pharmaceutical …

Impact Of Supplemental Home Enteral Feeding Postesophagectomy On Nutrition, Body Composition, Quality Of Life, And Patient Satisfaction, C.L. Donohoe, L.A. Healy, M. Fanning, Suzanne Doyle, A. Mchugh, J. Moore, N. Ravi, J.V. Reynolds

Articles

The aim of this prospective cohort study is to analyze the impact of supplemental home enteral nutrition (HEN) post-esophageal cancer surgery on nutritional parameters, quality of life (QL), and patient satisfaction. A systematic review reported that over 60% of patients lose >10% of both body weight and BMI by 6 months after esophagectomy. Enteral feeding (EF) is increasingly a modern standard postoperatively; however, the impact of extended HEN postdischarge has not been systematically studied. One hundred forty-nine consecutive patients [mean age 62 ± 9, 80% male,76% adenocarcinoma, 66% on multimodal protocols, and 69% with BMI ≥ 25 kg/m2] were studied. …

Sarcopenia: Prevalence, And Impact On Operative And Oncologic Outcomes In The Multimodal Management Of Locally Advanced Esophageal Cancer, Jessie Elliott, Suzanne Doyle, Conor Murphy, Sinead King, Emer Guinan, Peter Beddy, Narayanasamy Ravi, John Reynolds

Articles

Objective: The aim of this article was to study the prevalence and significance of sarcopenia in the multimodal management of locally advanced esophageal cancer (LAEC), and to assess its independent impact on operative and oncologic outcomes.

Summary of background data: Sarcopenia in cancer may confer negative outcomes, but its prevalence and impact on modern multimodal regimens for LAEC have not been systematically studied.

Methods: Two hundred fifty-two consecutive patients were studied. Lean body mass (LBM), skeletal muscle index (SMI), and fat mass (FM) were determined pre-treatment, preoperatively, and 1 year postoperatively. Sarcopenia was defined by computed tomography (CT) at L3 …

The "Eyes" Have It?-Intra- And Inter-Observer Reproducibility Of The Pd-L1 Companion Diagnostic Assay, Steven Gray, Mark Wright, Stephen Finn

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No abstract available.

Cancer Incidence In Ireland—The Possible Role Of Diet, Nutrition And Lifestyle, Daniel Mccartney, Declan Byrne, Marie Cantwell, Michael Turner

Articles

Aim This observational ecological study aims to compare Ireland’s age-specific cancer incidence rates (ASRs) with equivalent European and global data and to highlight possible dietary, nutritional and lifestyle contributors to cancer in Ireland.

Subjects and methods Using the International Agency for Research on Cancer’s (IARC) GLOBOCAN database, Irish ASRs for all-site cancer and for "lifestyle-related" cancers such as those of the colo-rectum, oesophagus, breast, lung and prostate were compared with European and global incidence data. Irish dietary and nutrient intake data were reviewed and evaluated in the context of these cancer incidence data and in relation to the established dietary, …

Extraction And Quantification Of Sinapinic Acid From Irish Rapeseed Meal And Assessment Of Angiotensin-I Converting Enzyme (Ace-I) Inhibitory Activity, Leah Quinn, Steven G. Gray, Steve Meaney, Stephen Finn, Padraig Mcloughlin, Maria Hayes

Articles

Phenolic compounds, including phenolic acids, are known to play a protective role against the development of cardiovascular disease. The aim of this work was to generate a phenolic acid extract from Irish rapeseed meal, to determine the quantity of sinapinic acid (SA) in this fraction and to assess the ability of this fraction to inhibit the enzyme angiotensin-I converting enzyme (ACE-I; EC 3.4.15.1). A crude phenolic extract (fraction 1), free phenolic acid containing extract (fraction 2), and an extract containing phenolic acids liberated from esters (fraction 3) were generated from Irish rapeseed meal using a methanol:acetone:water solvent mixture (7:7:6). The …

Justice Scalia, The Establishment Clause, And Christian Privilege, Caroline Mala Corbin

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No abstract provided.

Who Really Said What? Mobile Historical Situated Documentary As Liminal Learning Space, Owen Gottlieb

Articles

This article explores the complexities and affordances of historical representation that arose in the process of designing a mobile augmented reality video game for teaching history. The process suggests opportunities to push the historical documentary form in new ways. Specifically, the article addresses the shifting liminal space between historical fiction narrative, and historical interactive documentary narrative. What happens when primary sources, available for examination are placed inside of a historically inspired narrative, one that hews closely to the events, but creates drama through dialogues between player and historical figure? In this relatively new field of interactive historical situated documentary, how …

Regulating Secrecy, W. Nicholson Price Ii

Articles

Inventors face a stark choice between two intellectual property systems of protecting innovative ideas: patents and trade secrecy. But accounts of this choice underexplore the role of the regulators that dominate some areas of innovation. Regulation interacts with intellectual property exclusivity in socially problematic ways by encouraging secrecy at the expense of innovation, efficiency, and competition. This Article theorizes how regulation empowers intellectual property generally, explains why this strengthening is problematic for trade secrecy but not for patents, and offers the solution of regulator-enforced disclosure. When a regulator defines a product or a process, it becomes much harder to successfully …

Auditory Fatigue Model Applications To Predict Noise Induced Hearing Loss In Human And Chinchilla, Pengfei Sun, Daniel Fox, Kathleen Campbell, Jun Qin

Articles

Noise induced hearing loss (NIHL) remains a severe health problem worldwide. Current noise metrics and models have assessment limitations on gradually developing NIHL (GDNIHL). In this study, we apply a complex velocity level (CVL) auditory fatigue model to quantitatively assess the impact of basilar membrane (BM) movement on GDNIHL. The transfer functions of chinchilla and human auditory systems, including the triple-path nonlinear (TRNL) filters to simulate the inner ear responses, are applied to obtain BM velocity distribution. Chinchilla and human experimental hearing loss data are used to validate the proposed CVL model’s effectiveness. The results reveal that the developed CVL …

An Examination Of The Neural Unreliability Thesis Of Autism, John Butler, Sophie Molholm, Gizely Andrade, John J. Foxe

Articles

An emerging neuropathological theory of Autism, referred to here as “the neural unreliability thesis,” proposes greater variability in moment-to-moment cortical representation of environmental events, such that the system shows general instability in its impulse response function. Leading evidence for this thesis derives from functional neuroimaging, a methodology ill-suited for detailed assessment of sensory transmission dynamics occurring at the millisecond scale. Electrophysiological assessments of this thesis, however, are sparse and unconvincing. We conducted detailed examination of visual and somatosensory evoked activity using high-density electrical mapping in individuals with autism (N = 20) and precisely matched neurotypical controls (N = 20), recording …

Pivot Dublin: A Discussion On The Bid For Dublin To Become World Design Capital, Barry Sheehan, Ali Grehan

Articles

In this article, Barry Sheehan interviews Dublin City Architect, Ali Grehan, about PIVOT Dublin, the bid for World Design Council, how and why it came about, what happened to the bid and where PIVOT Dublin is now.

Modelling Random Antibody Adsorption And Immunoassay Activity, Dana Mackey, Eilis Kelly, Robert Nooney

Articles

One of the primary considerations in immunoassay design is optimizing the concentration of capture antibody in order to achieve maximal antigen binding and, subsequently, improved sensitivity and limit of detection. Many immunoassay technologies involve immobilization of the antibody to solid surfaces. Antibodies are large molecules in which the position and accessibility of the antigen-binding site depend on their orientation and packing density. In this paper we propose a simple mathematical model, based on the theory known as random sequential adsorption (RSA), in order to calculate how the concentration of correctly oriented antibodies (active site exposed for subsequent reactions) evolves during …

The Case Against Free Speech, Brian Leiter

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No abstract provided.

The Plain Language Court, David A. Strauss

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No abstract provided.

The Political Ideologies Of American Lawyers, Adam S. Chilton, Adam Bonica, Maya Sen

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No abstract provided.

Knowledge Goods And Nation-States, Daniel Hemel, Lisa Larrimore Ouellette

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No abstract provided.

The Constitutional Law Of Agenda Control, Aziz Huq

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No abstract provided.

Investigating The Impact Of Green Exercise On Population Health And Well-Being In A Small Community In Ireland:A Novel Approach Using A Natural Laboratory Ecosystem., Nollaig O'Sullivan, Aoife Donnelly, Tadhg Macintyre, Giles Warrington

Articles

Green exercise is defined as undertaking physical activity whilst being directly exposed to nature (Pretty et al., 2005; 2007). Pretty et al. (2003) were among the first wave of researchers to investigate the synergistic benefits of incorporating physical activity and exposure to the natural environment to produce positive psychological affect. Over the past decade, investigations into the possible additive effects on well-being of green exercise and how it can be used as an influential tool to help combat the rising rate of both physical inactivity and non –communicable disease has gained prominence in scientific literature. However, there is still a …

Bim Innovation Capability Programme: An Irish Bim Study, Barry Mcauley, Alan Hore, Roger West

Articles

In 2011 the Royal Institute of Architects Ireland (RIAI) conducted a survey which found that BIM adoption within Ireland was quite low at 16%. Over the last five years these figures have risen significantly, with the 2016 Irish Digital Transition Survey reporting that 76% of respondents possess confidence in their organisation’s BIM skills and knowledge. This represents a significant shift of BIM adoption in Ireland over the last five years.

The BIM Innovation Capability Programme (BICP) Irish BIM study, builds on the findings from the BICP Global BIM Study by providing an in depth review of BIM in Ireland with …

Dietary Nitrate Acutely And Markedly Increased Exhaled Nitric Oxide In A Cystic Fibrosis Case, Conor Kerley, Emma Kilbride, Peter Greally, Basil Elnazir

Articles

Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, antiinflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12 year-old, athletic male with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo.

Trouble On The Exchanges — Does The United Owe Billions To Health Insurers?, Nicholas Bagley

Articles

Yet another bruising fight has erupted over health care reform. On September 9, 2016, the Obama administration offered to open settlement negotiations with health insurers that have sued the United States to recover billions of dollars that they claim they are owed. Congressional Republicans are incensed, believing that any settlement would illegally squander taxpayer dollars in a lastgasp effort to save the Affordable Care Act (ACA).

An Investigation Into Spent Coffee Waste As A Renewable Source Of Bioactive Compounds And Industrially Important Sugars, Damhan Scully, Amit Jaiswal, Nissreen Abu-Ghannam

Articles

Conventional coffee brewing techniques generate vast quantities of spent espresso grounds (SEGs) rich in lignocellulose and valuable bioactives. These bioactive compounds can be exploited as a nutraceutical or used in a range of food products, while breakdown of lignocellulose generates metabolizable sugars that can be used for the production of various high-value products such as biofuels, amino acids and enzymes. Response surface methodology (RSM) was used to optimize the enzymatic saccharification of lignocellulose in SEGs following a hydrothermal pretreatment. A maximum reducing sugar yield was obtained at the following optimized hydrolysis conditions: 4.97 g of pretreated SEGs, 120 h reaction …

How And Why International Law Binds International Organizations, Kristina Daugirdas

Articles

For decades, controversy has dogged claims about whether and to what extent international law binds international organizations (“IOs”) like the United Nations and the International Monetary Fund. The question has important consequences for humanitarian law, economic rights, and environmental protection. In this Article, I aim to resolve the controversy by supplying a theory about when and how international law binds IOs. I conclude that international law binds IOs to the same degree that it binds states. That is, IOs are not more extensively or more readily bound; nor are they less extensively or less readily bound. This means that IOs, …

Microbial Enzyme Production Using Lignocellulosic Food Industry Wastes As Feedstock: A Review, Amit Jaiswal, Rajeev Ravindran

Articles

Enzymes are of great importance in the industry due to their substrate and product specificity, moderate reaction conditions, minimal by-product formation and high yield. They are important ingredients in several products and production processes. Up to 30% of the total production cost of enzymes is attributed to the raw materials costs. The food industry expels copious amounts of processing waste annually, which is mostlylignocellulosicin nature. Upon proper treatment,lignocellulosecan replace conventional carbon sources in media preparations for industrial microbial processes, such as enzyme production. However, wild strains of microorganisms that produce industrially important enzymes show low yield and cannot thrive on …

Fermentation-Assisted Extraction Of Isothiocyanates From Brassica Vegetable Using Box-Behnken Experimental Design, Amit Jaiswal, Nissreen Abu-Ghannam

Articles

Recent studies showed that Brassica vegetables are rich in numerous health-promoting compounds such as carotenoids, polyphenols, flavonoids, and glucosinolates (GLS), as well as isothiocyanates (ITCs) and are involved in health promotion upon consumption. ITCs are breakdown products of GLS, and typically used in the food industry as a food preservative and colouring agent. They are also used in the pharmaceutical industry due to their several pharmacological properties such as antibacterial, antifungal, antiprotozoal, anti-inflammatory, and chemoprotective effects, etc. Due to their widespread application in food and pharmaceuticals, the present study was designed to extract ITCs from York cabbage. In order to …