Digital Commons Network^™

Gold Nanostars For Efficient In Vitro And In Vivo Real-Time Sers Detection And Drug Delivery Via Plasmonic-Tunable Raman/Ftir Imaging, Furong Tian, Joao Conde, Chenchen Bao, Yunsheng Chen, James Curtin, Daxiang Cui

Articles

The application of plasmonic-enhanced Raman imaging of cancer cells and drug delivery is gaining momentum. Here, we propose a new theranostic strategy based on an efficient plasmonic-tunable Raman/Fourier transform infrared (FTIR) spectroscopy imaging, to simultaneously evaluate the anticancer drug scattering cellular imaging and the Raman scattering molecular vibration signals in living cells. This technique allows to monitoring the drug release throughout the cell cycle and in vivo biodistribution and biocompatibility with low dose drug therapy (200 µg/mL) and low toxicity effect. This system can directly track in real-time the delivery and release of an anticancer drug (mitoxantrone, MTX) from gold …

Developing Cultural Tourism Through Cross-Sector Co-Operation: Evidence From The West Of Ireland, Ziene Mottiar, Bernadette Quinn, Theresa Ryan

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Studies of co-operative activity in the tourism literature focus largely on linkages between tourism firms and little has been done to examine co-operation between tourism firms and those in other sectors. Yet the inter-dependency that exits between tourism and other sectors in product development is clearly apparent. One such example is in the production of cultural tourism where co-operation between the cultural and tourism sectors is a necessity. This paper reports on the findings of a project undertaken in regions in the west of Ireland. The research, identifies that while not without its challenges, there is a strong willingness for …

Incorporating Naturopathic Medicine Into A Hospital Setting: One Institution's Experience, Thomas Lanni, Maureen Anderson, Hallie Armstrong, Gail Elliott Patricolo

Articles

The number of patients seeking complementary health approaches combined with conventional treatments has grown considerably over the past decade. The current authors have previously described how an integrative medicine department was initiated and implemented at Beaumont Hospital, Royal Oak, Michigan. This article discusses how the integrative medicine department was expanded to include naturopathic medicine. This expansion was implemented because patients were taking herbs and supplements without their doctors' knowledge. This situation can be dangerous, especially for patients with cancer who are receiving chemotherapy, as various herbs and supplements can interact with treatment for these patients. Because the State of Michigan …

Assessing Stress Responses To Atmospheric Cold Plasma Exposure Using Escherichia Coli Knock Out Mutants, Lu Han, Daniela Boehm, Sonal Patil, Patrick J. Cullen, Paula Bourke

Articles

Aim: This study investigated the effect of Atmospheric cold plasma (ACP) exposure induced stress on microbial inactivation patterns and the regulation of genes involved in the microbial stress response in conjunction with key processing parameters of exposure time and post treatment storage time.

Methods and Results: Cell suspensions of Escherichia coli BW 25113 and its isogenic knock-out mutants in rpoS, soxR, soxS, oxyR and dnaK genes were treated with high voltage ACP in a sealed package for 1, 3 and 5 min followed by 0, 1 and 24 h post-treatment storage. ROS densities and colony formation were …

In Vitro Monitoring Of Time And Dose Dependent Cytotoxicity Of Aminated Nanoparticles Using Raman Spectroscopy, Esen Efeoglu, Alan Casey, Hugh Byrne

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No abstract provided.

Proceedings 26th Polar Libraries Colloquy Mapping Change: Chitduug Gha Nen' Ch'etnetl'edz, Daria O. Carle, Marvin Falk, Bev Ager, Stéfano Biondo, Joë Bouchard, Marcel Brannemann, Sandy Campbell, Andrew Gray, Gloria Hicks, Laura J. Kissel, Ulyana Koratkova, Peter Lund, Shannon C. Vossepoel, Ali Shiri, Dinesh Rathi, Cathy Cockney, Sharon Farnel, Elaine Maloney, Robyn Stobbs, Susanna Parikka, Shelly Sommer, Sharon Tahirkheli, Maribeth S. Murray, Steve Liang, James P. Badger, Bindu Panikkar, Byron Chu, Sandy Campell, Heidi Mccann

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Published July 2023 by the University of Alaska Anchorage, UAA/APU Consortium Library, and edited by Daria O. Carle. Copyright in individual papers is held by the contributors. A digital copy of this publication can be found at https://polarlibraries.org/colloquy-proceedings/ and in ScholarWorks, the University of Alaska’s Institutional Repository, https://scholarworks.alaska.edu/. A copy of the 2016 Colloquy program is also available at https://polarlibraries.org/colloquy-proceedings/. Further information on the Polar Libraries Colloquy, including details of membership and upcoming conferences, is available at https://polarlibraries.org

Spectroscopic Studies Of Anthracyclines: Structural Characterization And In Vitro Tracking, Zeineb Farhane, Hugh Byrne, Malgorzata Baranska

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A broad spectroscopic characterization, using ultraviolet-visible (UV-vis) and Fourier transform infrared absorption as well as Raman scattering, of two commonly used anthracyclines antibiotics (DOX) daunorubicin (DNR), their epimers (EDOX, EDNR) and ten selected analogs is presented. The paper serves as a comprehensive spectral library of UV-vis, IR and Raman spectra of anthracyclines in the solid state and in solution. The particular advantage of Raman spectroscopy for the measurement and analysis of individual antibiotics is demonstrated. Raman spectroscopy can be used to monitor the in vitro uptake and distribution of the drug in cells, using both 488 nm and 785 nm …

Profit-Shifting Structures: Making Ethical Judgments Objectively, Part 2, Jeffrey M. Kadet, David Koontz

Articles

MNCs and their advisors have seemingly taken ethics out of the mix when considering the profit-shifting tax structures they have so prolifically and enthusiastically implemented over the past several decades. There may be a variety of reasons for this. First, U.S. tax law is a self-assessment system, meaning that in most cases taxpayers compute and pay tax without advance approval of their tax positions from the IRS. No third party technical test or propriety standard has to be passed on the front end for any tax strategy or structure. Second, direct personal benefits accrue to management and advisors from implementing …

The Positive Psychology Of Maritime Health, Joanne Mcveigh, Malcolm Mclachlan, Bill Kavanagh

Articles

The remote, isolated, confined, and safety-critical environment of seafaring exposes seafarers to a very specific assortment of stressors. Research suggests that seafarers as a professional group are amongst those at high risk for stress and associated mental health conditions. This article explores positive psychology as an approach to supporting wellbeing at sea. Positive psychology may support health, positive attitudes and productive work behaviour; however it cannot and should not be employed as a means of inoculating seafarers against the negative consequences of fundamentally unreasonable work practices. Rather, positive psychology can help seafarers thrive in an overall context that recognises and …

Rational Basis Review And Fda Regulation: Why The Two Do Not Mix, Richard A. Epstein

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No abstract provided.

Developmental Jurisprudence, Emily Buss

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No abstract provided.

How To Study Constitution-Making: Hirschl, Elster, And The Seventh Inning Problem, Tom Ginsburg

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No abstract provided.

The Double-Edged Sword Of State Constitutional Law, Richard A. Epstein

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No abstract provided.

The Role Of Guidances In Modern Administrative Procedure: The Case For De Novo Review, Richard A. Epstein

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No abstract provided.

Dietary Nitrate Increases Exercise Tolerance In Patients With Non-Ischemic, Dilated Cardiomyopathy-A Double-Blind, Randomized, Placebo-Controlled, Crossover Trial., Conor Kerley, James O'Neill, Venu Reddy Bijjam, Ciara Blaine, Philip James, Liam Cormican

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No abstract provided.

Race, Place, And Power, Nicholas Stephanopoulos

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No abstract provided.

Profit-Shifting Structures: Making Ethical Judgments Objectively, Part 1, Jeffrey M. Kadet, David Koontz

Articles

MNCs and their advisors have seemingly taken ethics out of the mix when considering the profit-shifting tax structures they have so prolifically and enthusiastically implemented over the past several decades. There may be a variety of reasons for this. First, U.S. tax law is a self-assessment system, meaning that in most cases taxpayers compute and pay tax without advance approval of their tax positions from the IRS. No third party technical test or propriety standard has to be passed on the front end for any tax strategy or structure. Second, direct personal benefits accrue to management and advisors from implementing …

Linguistic Relativism And The Decline Of The Rule Of Law, Richard A. Epstein

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No abstract provided.

Cerebral Venous Engorgement In Hydrops Fetalis, Adnan I. Qureshi, Thomas Kohl

Articles

A 34-year-old gravida was diagnosed with hydrops fetalis, hydrothorax with cardiac compression, hygroma, ascites, and subcutaneous edema at 20 weeks of gestation...

The Scrivener's Error, Ryan D. Doerfler

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No abstract provided.

A Comparison Of Catabolic Pathways Induced In Primary Macrophages By Pristine Single Walled Carbon Nanotubes And Pristine Graphene, Caroline More, Jennifer Mcintyre, Luke O'Neill, Hugh Byrne

Articles

Understanding the correlation between the physico-chemical properties of carbonaceous nanomaterials and how these properties impact on cells and subcelluar mechanisms is critical to their risk assessment and safe translation into newly engineered devices. Here the toxicity, uptake and catabolic response of primary human macrophages to pristine graphene (PG) and pristine single walled carbon nanotubes (pSWCNT) are explored, compared and contrasted. The nanomaterial toxicity was assessed using three complementary techniques (live-dead assay, real time impedance technique and confocal microscopic analysis), all of which indicated no signs of acute cytotoxicity in response to PG or pSWCNT. Transmission electron microscopy (TEM) demonstrated that …

Marriage Is On The Decline And Cohabitation Is On The Rise: At What Point, If Ever, Should Unmarried Partners Acquire Marital Rights?, Lawrence W. Waggoner

Articles

This article draws attention to the cultural shift in the formation of families that has been and is taking place in this country: Marriage is on the decline and cohabitation is on the rise. Part II documents this cultural shift by using recent government data to trace the decline of marriage and the rise of cohabitation. Between 2000 and 2010, the population grew by 9.71%, but the husband-and-wife households only grew by 3.7%, while the unmarried-couple households grew by 41.4%. Because of the Supreme Court's decidion in Obergefell v. Hodges, marriage is now universally available to same-sex couples. Part …

Modification Of The In Vitro Uptake Mechanism And Anti-Oxidant Levels In Hacat Cells And Resultant Changes To Toxicity And Oxidative Stress Of G4 And G6 Poly (Amido Amine) Dendrimer Nanoparticles., Marcus Maher, Hugh Byrne

Articles

The mechanism of cellular uptake by endocytosis and subsequent oxidative stress has been identified as the paradigm for the toxic response of cationically surface charged nanoparticles. In an attempt to circumvent the process, the effect of increased cellular membrane permeability on the uptake mechanisms of poly (amidoamine) dendrimers generation 4 (G4) and 6 (G6) in vitro was investigated. Immortalised, non-cancerous human keratinocyte (HaCaT) cells were treated with DL-Buthionine-(S,R)-sulfoximine (BSO). Active uptake of the particles was monitored using fluorescence microscopy to identify and quantify endosomal activity and resultant oxidative stress, manifest as increased levels of reactive oxygen species, monitored using the …

Screening The Low Molecular Weight Fraction Of Human Serum Using Atr-Ir Spectroscopy, Franck Bonnier, Matthew J. Baker, Hugh Byrne

Articles

Vibrational spectroscopic techniques can detect small variations in molecular content, linked with disease, showing promise for screening and early diagnosis. Biological fluids, particularly blood serum, are potentially valuable for diagnosis purposes. The so-called Low Molecular Weight Fraction (LMWF) contains the associated peptidome and metabolome and has been identified as potentially the most relevant molecular population for disease-associated biomarker research. Although vibrational spectroscopy can deliver a specific chemical fingerprint of the samples, the High Molecular Weight Fraction (HMWF), composed of the most abundant serum proteins, strongly dominates the response and ultimately makes the detection of minor spectral variations a challenging task. …

Book Review: Laugesen & Gauld. Democratic Governance & Health: Hospitals, Politics And Health In New Zealand, Vivienne Byers

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No abstract provided.

Biodegradable Magnesium Alloys For Orthopaedic Applications: A Review On Corrosion, Biocompatibility And Surface Modifications., Sankalp Agarwal, James Curtin, Brendan Duffy, Swarna Jaiswal

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Magnesium (Mg) and its alloys have been extensively explored as potential biodegradable implant materials for orthopaedic applications (e.g. Fracture fixation). However, the rapid corrosion of Mg based alloys in physiological conditions has delayed their introduction for therapeutic applications to date. The present review focuses on corrosion, biocompatibility and surface modifications of biodegradable Mg alloys for orthopaedic applications. Initially, the corrosion behaviour of Mg alloys and the effect of alloying elements on corrosion and biocompatibility is discussed. Furthermore, the influence of polymeric deposit coatings, namely sol-gel, synthetic aliphatic polyesters and natural polymers on corrosion and biological performance of Mg and its …

The Broken-Hearted Lover: Erwin Chemerinsky's Longings For A Mythical Court, Gerald Rosenberg

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No abstract provided.

Defining Single Molecular Forces Required For Notch Activation Using Nano Yoyo, Farhan Chowdhury, Isaac T. S. Li, Thuy Ngo, Benjamin J. Leslie, Byoung Kim, Joshua Sokoloski, Elizabeth Weiland, Xuefeng Wang, Yann Chemla, Timothy Lohman, Taekjip Ha

Articles

Notch signaling, involved in development and tissue homeostasis, is activated at the cell-cell interface through ligand-receptor interactions. Previous studies have implicated mechanical forces in the activation of Notch receptor upon binding to its ligand. Here we aimed to determine the single molecular force required for Notch activation by developing a novel low tension gauge tether (LTGT). LTGT utilizes the low unbinding force between single-stranded DNA (ssDNA) and E. coli ssDNA binding protein (SSB) (~4 pN dissociation force at 500 nm/s pulling rate). The ssDNA wraps around SSB and, upon application of force, unspools from SSB, much like the unspooling of …

Trade And Tradeoffs: The Case Of International Patent Exhaustion, Daniel Hemel

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No abstract provided.

Cba At The Pto, Jonathan Masur

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No abstract provided.