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Addressing Vision Impairment In Mozambique And The Africa Region, Stephen Thompson, Kovin Naidoo, Joel Bambamba, Vanessa Moodley, Diane Van Staden, Amanda Forde, Kajal Shah, Luigi Bilotto, James Loughman Jan 2019

Addressing Vision Impairment In Mozambique And The Africa Region, Stephen Thompson, Kovin Naidoo, Joel Bambamba, Vanessa Moodley, Diane Van Staden, Amanda Forde, Kajal Shah, Luigi Bilotto, James Loughman

Articles

The Mozambique Eyecare Project was an international partnership to implement and research eye health education in Mozambique and the Africa region. An optometry degree was developed at Universidade Lúrio, Mozambique. In addition, existing eye health workers were upskilled with training. Researchers from various disciplines evaluated the project and its potential for impact on eye health in the region. The body of evidence generated from the research provides useful lessons for development programmes in general, as well as specific lessons for delivering eye health education and service delivery models for low income settings.


Raman Spectroscopic Analysis Of Saliva For The Diagnosis Of Oral Cancer: A Systematic Review, Genecy Calado, Isha Behl, Amuthachelvi Daniel, Hugh Byrne, Fiona Lyng Jan 2019

Raman Spectroscopic Analysis Of Saliva For The Diagnosis Of Oral Cancer: A Systematic Review, Genecy Calado, Isha Behl, Amuthachelvi Daniel, Hugh Byrne, Fiona Lyng

Articles

Abstract Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide, and new protocols for routine and early detection are required. Raman spectroscopy is an optical based method that can provide sensitive and non-invasive real time detailed information on the biochemical content of a sample like saliva, through the unique vibrations of its constituent molecules and this is sensitive to changes associated with disease. A comprehensive systematic review of the available scientific literature related to Raman spectroscopy of human saliva for diagnosis of OSCC was performed. The 785 nm laser line was most applied wavelength along with …


Principal Components Analysis Of Raman Spectral Data For Screening Of Hepatitis C Infection, A. Dita, H. Nawaz, T. Mahmood, M. Tahir, N. Rashid, Muhammad Mudassar, A.A.H. Alsaadi, Hugh Byrne Jan 2019

Principal Components Analysis Of Raman Spectral Data For Screening Of Hepatitis C Infection, A. Dita, H. Nawaz, T. Mahmood, M. Tahir, N. Rashid, Muhammad Mudassar, A.A.H. Alsaadi, Hugh Byrne

Articles

In the current study, Raman spectroscopy is employed for the identification of the biochemical changes taking place during the development of Hepatitis C. The Raman spectral data acquired from the human blood plasma samples of infected and healthy individuals is analysed by Principal Components Analysis and the Raman spectral markers of the Hepatitis C Virus (HCV) infection are identified. Spectral changes include those associated with nucleic acidsat720 cm−1, 1077 cm−1 1678 (CO stretching mode of dGTP of RNA), 1778 cm−1 (RNA), with proteins at 1641 cm−1(amide-I), 1721 cm−1(CC stretching of proteins) and lipids at 1738 cm−1(CO of ester group in …


Calculating Restaurant Failure Rates Using Longitudinal Census Data, J. J. Healy, Máirtín Mac Con Iomaire Jan 2019

Calculating Restaurant Failure Rates Using Longitudinal Census Data, J. J. Healy, Máirtín Mac Con Iomaire

Articles

Failure rates in the restaurant industry are popularly perceived to be far higher than they actually are. This paper calculates failure rates in the Irish Food and Drinks Sector (IFDS), for the first time, using longitudinal census data from the Central Statistics Office (CSO) in Ireland, which follows the European statistical classification of economic activity (NACE). The results are compared with previously published literature on restaurant failure rates in the United States of America. This study also compares IFDS failure rates with other industry sectors in Ireland (construction, manufacturing). Drawing on Stinchcombe’s ’liability of newness’ theory, the informal fallacies theory …


A Comparative Analysis Of The Attitudes Of Rural And Urban Consumers Towards Cultured Meat, Elaine Shaw, Máirtín Mac Con Iomaire Jan 2019

A Comparative Analysis Of The Attitudes Of Rural And Urban Consumers Towards Cultured Meat, Elaine Shaw, Máirtín Mac Con Iomaire

Articles

Purpose – The purpose of this paper is to perform a comparative analysis on the attitudes of rural and urban Irish consumers towards cultured meat.

Design/methodology/approach – A mixed methods exploratory sequential design was used. This involved collecting qualitative data first, through group interviews, and using the results of these to design the questionnaires for the quantitative data collection, which was analysed using SPSS 24.0 ®.

Findings – Urban consumers were more receptive towards cultured meat and more concerned about the environmental impact of current meat production practices. Rural consumers were more concerned about the possible damaging effect cultured meat …


The Role Of Mineral And Trace Element Supplementation In Exercise And Athletic Performance: A Systematic Review, Shane Heffernan, Katy Horner, Giuseppe De Vito, Gillian Conway Jan 2019

The Role Of Mineral And Trace Element Supplementation In Exercise And Athletic Performance: A Systematic Review, Shane Heffernan, Katy Horner, Giuseppe De Vito, Gillian Conway

Articles

Minerals and trace elements (MTEs) are micronutrients involved in hundreds of biological processes. Deficiency in MTEs can negatively affect athletic performance. Approximately 50% of athletes have reported consuming some form of micronutrient supplement; however, there is limited data confirming their efficacy for improving performance. The aim of this study was to systematically review the role of MTEs in exercise and athletic performance. Six electronic databases and grey literature sources (MEDLINE; EMBASE; CINAHL and SportDISCUS; Web of Science and clinicaltrials.gov) were searched, in accordance with PRISMA guidelines. Results: 17,433 articles were identified and 130 experiments from 128 studies were included. Retrieved …


Evaluating Food Safety Knowledge And Practices Among Foodservice Staff In Al Madinah Hospitals, Saudi Arabia, Anushree Priyadarshini, Nada Ahmad Alqurashi, Amit Jaiswal Jan 2019

Evaluating Food Safety Knowledge And Practices Among Foodservice Staff In Al Madinah Hospitals, Saudi Arabia, Anushree Priyadarshini, Nada Ahmad Alqurashi, Amit Jaiswal

Articles

This study examines food safety knowledge and practices of food service staff in Al Madinah hospitals, Saudi Arabia. A total of 163 food service staff participated voluntarily from 10 hospitals across the city of Al Madinah. The participants completed a questionnaire composed of threeparts: Generalcharacteristics,foodsafetyknowledge,andfoodsafetypractices. Resultsshowed that respondents generally had good food safety knowledge with the highest pass rate of 77.9% for knowledge of cross contamination followed by 52.8% for knowledge of food poisoning, and 49.7% of knowledge of food storage. Food safety practices were also strongly observed in the hospitals with a pass rate of 92.6%. Food safety knowledge …


Antimicrobial Effects Of Microwave-Induced Plasma Torch (Minimip) Treatment On Candida Albicans Biofilms, Oliver Handorf, Uta Schnabel, André Bösel, Thomas Weihe, Sander Bekeschus, Alexander C. Graf, Jörg Ehlbeck Jan 2019

Antimicrobial Effects Of Microwave-Induced Plasma Torch (Minimip) Treatment On Candida Albicans Biofilms, Oliver Handorf, Uta Schnabel, André Bösel, Thomas Weihe, Sander Bekeschus, Alexander C. Graf, Jörg Ehlbeck

Articles

The susceptibility of Candida albicans biofilms to a non-thermal plasma treatment has been investigated in terms of growth, survival and cell viability by a series of in vitro experiments. For different time periods , the C. albicans strain SC5314 was treated with a microwave-induced plasma torch (MiniMIP). The MiniMIP treatment had a strong effect (reduction factor (RF) = 2.97 after 50 s treatment) at a distance of 3 cm between the nozzle and the superior regions of the biofilms. In addition, a viability reduction of 77% after a 20 s plasma treatment and a metabolism reduction of 90% after a …


Investigation Of Mechanisms Involved In Germination Enhancement Of Wheat (Triticum Aestivum) By Cold Plasma: Effects On Seed Surface Chemistry And Characteristics, Agata Los, Dana Ziuzina, Daniela Boehm, Patrick J. Cullen, Paula Bourke Jan 2019

Investigation Of Mechanisms Involved In Germination Enhancement Of Wheat (Triticum Aestivum) By Cold Plasma: Effects On Seed Surface Chemistry And Characteristics, Agata Los, Dana Ziuzina, Daniela Boehm, Patrick J. Cullen, Paula Bourke

Articles

Recent reports indicate that atmospheric cold plasma (ACP) treatment of seeds can enhance their germination, however, the mechanisms of action are not yet entirely clear. In the present work, we report on the effects of plasma treatment on wheat seed germination and seedling growth. Additionally, changes in the surface chemistry and characteristics of the wheat seeds exposed to plasma were investigated. Treatments of 30–60 s significantly enhanced the germination rate and showed positive effects on seedling growth. ACP resulted in changes of seed surface and chemical characteristics including water uptake and contact angle values. Changes in seed pH and total …


Laser-Induced Breakdown Spectroscopy For Food Authentication, Maria Markiewicz-Keszycka, Raquel Cama-Moncunill, Maria Piedad Casado-Gavalda, Carl Sullivan, P. J. Cullen Jan 2019

Laser-Induced Breakdown Spectroscopy For Food Authentication, Maria Markiewicz-Keszycka, Raquel Cama-Moncunill, Maria Piedad Casado-Gavalda, Carl Sullivan, P. J. Cullen

Articles

With the globalisation of food markets, food authentication has become a significant concern worldwide to ensure food safety and to avoid origin and quality fraud. A multi-elemental fingerprint is a powerful tool for detection of adulterants and geographical origin of foods. Laser-induced breakdown spectroscopy (LIBS) is a promising technique that can provide a mineral fingerprint of food products. LIBS allows a rapid, high-throughput, micro-destructive and multi-elemental analysis of a wide range of samples type. It has already been demonstrated by several authors that LIBS can be successfully used for food authentication. Although LIBS shows excellent potential for at-line or portable …


Nanostructured Materials For Food Applications: Spectroscopy, Microscopy And Physical Properties, Shubham Sharma, Swana Jaiswal, Brendan Duffy, Amit Jaiswal Jan 2019

Nanostructured Materials For Food Applications: Spectroscopy, Microscopy And Physical Properties, Shubham Sharma, Swana Jaiswal, Brendan Duffy, Amit Jaiswal

Articles

Nanotechnology deals with the matter of atomic or molecular scale. Other factors that define the character of a nanoparticle are its physical and chemical properties, such as surface area, surface charge, hydrophobicity of the surface, the thermal stability of the nanoparticle, and its antimicrobial activity. A nanoparticle is usually characterized by using microscopic and spectroscopic techniques. Microscopic techniques are used to characterize the size, shape, and location of the nanoparticle by producing an image of the individual nanoparticle. Several techniques, such as scanning electron microscopy (SEM), transmission electron microscopy/high resolution transmission electron microscopy (TEM/HRTEM), atomic force microscopy (AFM) and scanning …


Proximate Composition And Anti-Nutritional Factors Of Fava-Bean (Vicia Faba), Green-Pea And Yellow-Pea (Pisum Sativum) Flour, Kim A. Millar, Eimear Gallagher, Roisin Burke, Sinead Mccarthy, Catherine Barry-Ryan Jan 2019

Proximate Composition And Anti-Nutritional Factors Of Fava-Bean (Vicia Faba), Green-Pea And Yellow-Pea (Pisum Sativum) Flour, Kim A. Millar, Eimear Gallagher, Roisin Burke, Sinead Mccarthy, Catherine Barry-Ryan

Articles

Pulse grains were identified as a key resource for food innovation during the International Year of the Pulse (IYP), 2016. Pulse flour offers a sustainable source of plant protein for innovation in protein enriched cereal based foods. Fava-bean (Vicia faba), green- and yellow-pea (Pisum sativum) flour were analysed for proximate composition, minerals, amino acids, phenolic content, phytic acid and trypsin inhibitory activity. Fava-bean flour had the highest protein content (28 g/100 g), while green-pea flour had the highest total dietary fibre content (15 g/100 g). All three flours contained essential amino acids in adequate quantity, highlighting them as a source …


Efficacy Of Cold Plasma Functionalised Water For Improving Microbiological Safety Of Fresh Produce And Wash Water Recycling, Apurva Patange, Peng Lu, Daniela Boehm, Patrick J. Cullen, Paula Bourke Jan 2019

Efficacy Of Cold Plasma Functionalised Water For Improving Microbiological Safety Of Fresh Produce And Wash Water Recycling, Apurva Patange, Peng Lu, Daniela Boehm, Patrick J. Cullen, Paula Bourke

Articles

Atmospheric cold plasma (ACP) is an effective method for microbiological decontamination. This study evaluated an alternative water-based decontamination approach for inactivation of bacterial population from fresh produce and in the wash water generated from fresh produce washing. The study characterised ACP inactivation of attached Listeria innocua and Pseudomonas fluorescens inoculated on lettuce in comparison to chlorine treatment. P. fluorescens was sensitive to ACP treatment and was reduced below detection limit within 3 min of treatment. L. innocua population was reduced by ∼2.4 Log10 CFU/g after 5 min of treatment; showing similar inactivation efficacy to chlorine treatment. The microbial load in …


Effect Of Cold Plasma On The Techno-Functional Properties Of Animal Protein Food Ingredients, Juan M. Pérez-Andrés, Carlos Álvarez, Patrick J. Cullen, Brijesh K. Tiwari Jan 2019

Effect Of Cold Plasma On The Techno-Functional Properties Of Animal Protein Food Ingredients, Juan M. Pérez-Andrés, Carlos Álvarez, Patrick J. Cullen, Brijesh K. Tiwari

Articles

Proteins, as food ingredients, are employed in the food industry, not only for their high nutritional value, but also because of their techno-functional properties. Modifications of their native structure due to the action of external factors such as pH, temperature or processing by emerging technologies, can lead to changes in their functionality; and consequently, their applicability. The present study investigates the effects of cold atmospheric air plasma on the techno-functional properties of two common food ingredients (haemoglobin and gelatine from pork), and a novel source of functional proteins extracted from a meat co-product (bovine lung protein). Significant effects were found …


Wholesomeness And Safety Aspects Of Irradiated Foods, Rajeev Ravindran, Amit Jaiswal Jan 2019

Wholesomeness And Safety Aspects Of Irradiated Foods, Rajeev Ravindran, Amit Jaiswal

Articles

Food processing techniques are inevitable technological measures that aim to increase and sustain the quality of agricultural products. This is traditionally achieved by the application of heat or exposure to chemicals. Since the advent of X-rays, food scientists have been evaluating the prospect of employing ionising radiations for pest removal, sprouting inhibition and shelf-life extension of food products. Gamma radiation, electron beam and X-rays have emerged as the favoured methods of food irradiation in recent years. Several decades of research have endeavoured to determine the advantage and disadvantage of subjecting food materials to radiation. This has resulted in several international …


Exploring How Age Influences Sensory Perception, Thirst And Hunger During The Consumption Of Oral Nutritional Supplements Using The Check-All-That-Apply Methodology, Emma Regan, Graham O'Neill, Scott C. Hutchings, Dolores O'Riordan Jan 2019

Exploring How Age Influences Sensory Perception, Thirst And Hunger During The Consumption Of Oral Nutritional Supplements Using The Check-All-That-Apply Methodology, Emma Regan, Graham O'Neill, Scott C. Hutchings, Dolores O'Riordan

Articles

The Check-all-that-apply (CATA) method has been widely used for the sensory characterisation of many different foods and beverages. However, this methodology has been rarely used with older adults. The aim of this study was to measure the effectiveness of the CATA methodology to investigate the differences in sensory perception of Oral Nutritional Supplements (ONS) between younger and community dwelling older adults over successive sips of a full volume of two ONS. The study also sought to measure the effects of ONS on thirst, hunger and fullness. 160 participants (eighty aged over 65 and eighty aged 18-35) evaluated two ONS over …


A Review Of Human Factors And Food Safety In Ireland, Ciara Walsh, Maria Chiara Leva Jan 2019

A Review Of Human Factors And Food Safety In Ireland, Ciara Walsh, Maria Chiara Leva

Articles

Increased product shelf-life and globalisation have led to longer and vastly more complicated food chains; potentially presenting greater opportunity for contamination and microbial growth to occur. Modern food safety management systems risk assess hazards (based on current scientific data) and strive to control these, often extensive and convoluted, food production/supply chains through appropriate good hygiene practices (GHP) and HACCP. Contamination of food as a result of human error can undermine even the most carefully prepared and executed HACCP system – culminating in foodborne infection, outbreaks, reputable damage, and erosion of consumer trust. This paper provides a review on the effect …


Current Source Density Approaches Improve Spatial Resolution In Event Related Potential Analysis In People With Parkinson's Disease, Conor Fearon, John Butler, Saskia M. Waechter, Isabelle Killane, Richard B. Reilly, Timothy Lynch Jan 2019

Current Source Density Approaches Improve Spatial Resolution In Event Related Potential Analysis In People With Parkinson's Disease, Conor Fearon, John Butler, Saskia M. Waechter, Isabelle Killane, Richard B. Reilly, Timothy Lynch

Articles

No abstract provided.


Spheroid-3d And Monolayer-2d Intestinal Electrochemical Biosensor For Toxicity/Viability Testing: Applications In Drug Screening, Food Safety, And Environmental Pollutant Analysis, Evangelia Flampouri, Shahzad Imar, Kieran O'Connell, Baljit Singh Jan 2019

Spheroid-3d And Monolayer-2d Intestinal Electrochemical Biosensor For Toxicity/Viability Testing: Applications In Drug Screening, Food Safety, And Environmental Pollutant Analysis, Evangelia Flampouri, Shahzad Imar, Kieran O'Connell, Baljit Singh

Articles

The rise of three-dimensional cell culture systems that provide in vivo-like environments for pharmaco-toxicological models has prompted the need for simple and robust viability assays suitable for complex cell architectural structures. This study addresses that challenge with the development of an in vitro enzyme based electrochemical sensor for viability/cytotoxicity assessment of two-dimensional (2D) monolayer and three-dimensional (3D) spheroid culture formats. The biosensor measures the cell viability/toxicity via electrochemical monitoring of the enzymatic activity of nonspecific esterases of viable cells, through the hydrolysis of 1-naphthyl acetate to 1-naphthol. The proposed sensor demonstrated strong correlation (r = 0.979) with viable …


Electrochemical Enzyme-Linked Immunosorbent Assay (E-Elisa) For Parasitic Nematode: Ostertagia Ostertagi (Brown Stomach Worm) Infections In Dairy Cattle, Baljit Singh, Evangelia Flampouri, Eithne Dempsey Jan 2019

Electrochemical Enzyme-Linked Immunosorbent Assay (E-Elisa) For Parasitic Nematode: Ostertagia Ostertagi (Brown Stomach Worm) Infections In Dairy Cattle, Baljit Singh, Evangelia Flampouri, Eithne Dempsey

Articles

A sensitive electrochemical immunoassay (e-ELISA) has been developed for the detection of the gastrointestinal parasitic nematode Ostertagia ostertagi (brown stomach worm) in infected and control serum samples. An antigen-indirect immunoassay format was employed to detect the presence of O. ostertagi antibodies, coupled with an anti-species monoclonal horseradish peroxidase (HRP) conjugate. ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) and TMB (3,3',5,5'-tetramethylbenzidine/hydrogen peroxide) were investigated as both chromogenic visualising reagents for optical ELISA and electroactive substrates for electrochemical ELISA in the HRP catalysed oxidation reaction. Coulometry was applied for the detection of O. ostertagi antibodies (via TMB electrochemistry) and compared with the commercial optical ELISA (ABTS …


Interpreting And Reporting Principal Component Analysis In Food Science Analysis And Beyond, D. Cozzolino, A. Power, J. Chapman Jan 2019

Interpreting And Reporting Principal Component Analysis In Food Science Analysis And Beyond, D. Cozzolino, A. Power, J. Chapman

Articles

Principal component analysis (PCA) is one of the most widely used data mining techniques in sciences and applied to a wide type of datasets (e.g. sensory, instrumental methods, chemical data). However, several questions and doubts on how to interpret and report the results are still asked every day from students and researchers. This brief communication is inspired in relation to those questions asked by colleagues and students. Please note that this article is a focus on the practical aspects, use and interpretation of the PCA to analyse multiple or varied data sets. In summary, the application of the PCA provides …


Improving Extraction Processes Of Crustacean Chitin Using Solid State Analytical Techniques, Fionn O'Fearghail, Michelle Giltrap, Christine O'Connor, Patrice Behan Jan 2019

Improving Extraction Processes Of Crustacean Chitin Using Solid State Analytical Techniques, Fionn O'Fearghail, Michelle Giltrap, Christine O'Connor, Patrice Behan

Articles

Solid state analytical techniques are becoming more widely used for the analysis of a range of organic products which demonstrate very poor solubility in both common organic and polar solvents and as such cannot be accurately characterised using solution based techniques. Primarily used as a secondary technique for qualitative analysis of insoluble intermediates and products in organic synthesis, 13C CP-MAS NMR can be utilised in tandem with a targeted extraction and clean up procedure for accurate quantitative analysis of insoluble bio-molecules of interest. Here solid state 13C CP-MAS NMR is utilised as the primary analytical technique in the characterisation of …


Discrimination Of Breast Cancer From Benign Tumours Using Raman Spectroscopy, Fiona Lyng, Damien Traynor, Thi Nguyet Que Nguyen, Aidan Meade, Fazle Rakib, Rafif Al-Saady, Erik Goormaghtigh, Khalid Al-Saad, Mohamed H. Ali Jan 2019

Discrimination Of Breast Cancer From Benign Tumours Using Raman Spectroscopy, Fiona Lyng, Damien Traynor, Thi Nguyet Que Nguyen, Aidan Meade, Fazle Rakib, Rafif Al-Saady, Erik Goormaghtigh, Khalid Al-Saad, Mohamed H. Ali

Articles

Breast cancer is the most common cancer among women worldwide, with an estimated 1.7 million cases and 522,000 deaths in 2012. Breast cancer is diagnosed by histopathological examination of breast biopsy material but this is subjective and relies on morphological changes in the tissue. Raman spectroscopy uses incident radiation to induce vibrations in the molecules of a sample and the scattered radiation can be used to characterise the sample. This technique is rapid and non-destructive and is sensitive to subtle biochemical changes occurring at the molecular level. This allows spectral variations corresponding to disease onset to be detected. The aim …


Five-Year Follow Up Of A Low Glycaemic Index Dietary Randomised Controlled Trial In Pregnancy—No Long-Term Maternal Effects Of A Dietary Intervention, E.C. O'Brien, Aisling A. Geraghty, Elizabeth O'Sullivan, J.A. Riordan, Mary K. Horan, Elizabeth Larkin, John Mehegan, P.J. Twomey, Fionnuala M. Mcauliffe Jan 2019

Five-Year Follow Up Of A Low Glycaemic Index Dietary Randomised Controlled Trial In Pregnancy—No Long-Term Maternal Effects Of A Dietary Intervention, E.C. O'Brien, Aisling A. Geraghty, Elizabeth O'Sullivan, J.A. Riordan, Mary K. Horan, Elizabeth Larkin, John Mehegan, P.J. Twomey, Fionnuala M. Mcauliffe

Articles

Objective: To determine whether a dietary intervention in pregnancy had a lasting effect on maternal outcomes of diet, HbA1c and weight retention 5 years post-intervention; and to establish whether modifiable maternal behaviours were associated with these outcomes. Design: Randomised control trial of low glycaemic index (GI) diet in pregnancy with longitudinal follow up to 5 years post-intervention. Setting: Dublin, Ireland (2007–2016). Population: In all, 403 women of 759 (53.1%) were followed up at 5 years. A total of 370 (intervention n = 188; control n = 182) were included in this analysis. Methods: Fasting glucose was measured at 13 and …


Maternal Sociodemographic And Health Behaviours Associated With Adiposity In Infants As Measured By Air Displacement Plethysmography., A. Bennett Jan 2019

Maternal Sociodemographic And Health Behaviours Associated With Adiposity In Infants As Measured By Air Displacement Plethysmography., A. Bennett

Articles

BACKGROUND:

Identifying modifiable factors associated with body fat in infancy may improve health outcomes. Few studies have examined factors associated with percentage body fat calculated using air displacement plethysmography, a gold standard technique.

AIMS:

To investigate maternal sociodemographic and health behaviour characteristics associated with percentage body fat in offspring at birth.

STUDY DESIGN:

Observational cross-sectional study in which the body composition of term infants was measured by air displacement plethysmography during the hospital stay after birth.

SUBJECTS:

One-hundred-and-ninety-six women and their term (37-42 weeks) infants.

OUTCOME MEASURES:

Associations between infant body composition and maternal sociodemographic and health characteristics.

RESULTS:

One-hundred-and-ninety-six …


Biological Membranes In Ev Biogenesis, Stability, Uptake, And Cargo Transfer: An Isev Position Paper Arising From The Isev Membranes And Evs Workshop, Ashley E. Russell, Alexandra Sneider, Kenneth W. Witwer, Paola Bergese, Suvendra N. Bhattacharyya, Alexander Cocks, Emanuele Cocucci, Uta Erdbrugger, Juan M. Falcon-Perez, David W. Freeman, Thomas M. Gallagher, Shuaishuai Hu, Yiyao Huang, Steven M. Jay, Shin-Ichi Kano, Gregory Lavieu, Aleksandra Leszczynska, Alicia M. Llorente, Quan Lu, Vasiliki Mahairaki, Dillon C. Muth, Nicole Noren Hooten, Matias Ostrowski, Ilaria Prada, Susmita Sahoo, Tine Hiroth Schoyen, Lifu Sheng, Deanna Tesch, Guillaume Van Niel, Roosmarijn E. Vandenbroucke, Frederik J. Verweij, Ana V. Villar, Marca Wauben, Hang Yin, David Raul Francisco Carter, Pieter Vader Jan 2019

Biological Membranes In Ev Biogenesis, Stability, Uptake, And Cargo Transfer: An Isev Position Paper Arising From The Isev Membranes And Evs Workshop, Ashley E. Russell, Alexandra Sneider, Kenneth W. Witwer, Paola Bergese, Suvendra N. Bhattacharyya, Alexander Cocks, Emanuele Cocucci, Uta Erdbrugger, Juan M. Falcon-Perez, David W. Freeman, Thomas M. Gallagher, Shuaishuai Hu, Yiyao Huang, Steven M. Jay, Shin-Ichi Kano, Gregory Lavieu, Aleksandra Leszczynska, Alicia M. Llorente, Quan Lu, Vasiliki Mahairaki, Dillon C. Muth, Nicole Noren Hooten, Matias Ostrowski, Ilaria Prada, Susmita Sahoo, Tine Hiroth Schoyen, Lifu Sheng, Deanna Tesch, Guillaume Van Niel, Roosmarijn E. Vandenbroucke, Frederik J. Verweij, Ana V. Villar, Marca Wauben, Hang Yin, David Raul Francisco Carter, Pieter Vader

Articles

Paracrine and endocrine roles have increasingly been ascribed to extracellular vesicles (EVs) generated by multicellular organisms. Central to the biogenesis, content, and function of EVs are their delimiting lipid bilayer membranes. To evaluate research progress on membranes and EVs, the International Society for Extracellular Vesicles (ISEV) conducted a workshop in March 2018 in Baltimore, Maryland, USA, bringing together key opinion leaders and hands-on researchers who were selected on the basis of submitted applications. The workshop was accompanied by two scientific surveys and covered four broad topics: EV biogenesis and release; EV uptake and fusion; technologies and strategies used to study …


Disarming Pseudomonas Aeruginosa Virulence By The Inhibitory Action Of 1,10-Phenanthroline-5,6-Dione- Based Compounds: Elastase B (Lasb) As A Chemotherapeutic Target, Anna Clara M. Galdino, Livia Vigano, Aleaxandre A. De Castron, Elaine F.F; Da Cunha, Thais P. Mello, Larissa M. Mattos, Marcos D. Pereira, Mary Hunt, Megan O'Shaughnessy, Orla L. Howe, Michael Devereux, Malachy Mccann, Teodorico C. Ramalho, Marta H. Branquinha, André L.S. Santos Jan 2019

Disarming Pseudomonas Aeruginosa Virulence By The Inhibitory Action Of 1,10-Phenanthroline-5,6-Dione- Based Compounds: Elastase B (Lasb) As A Chemotherapeutic Target, Anna Clara M. Galdino, Livia Vigano, Aleaxandre A. De Castron, Elaine F.F; Da Cunha, Thais P. Mello, Larissa M. Mattos, Marcos D. Pereira, Mary Hunt, Megan O'Shaughnessy, Orla L. Howe, Michael Devereux, Malachy Mccann, Teodorico C. Ramalho, Marta H. Branquinha, André L.S. Santos

Articles

negative pathogen Pseudomonas aeruginosa, and this enzyme orchestrates several physiopathological events during bacteria-host interplays. LasB is considered to be a potential target for the development of an innovative chemotherapeutic approach, especially against multidrug-resistant strains. Recently, our group showed that 1,10-phenanthroline-5,6-dione (phendione), [Ag(phendione)2]ClO4 (Ag-phendione) and [Cu(phendione)3](ClO4)2.4H2O (Cu-phendione) had anti-P. aeruginosa action against both planktonic- and biofilm-growing cells. In the present work, we have evaluated the effects of these compounds on the (i) interaction with the lasB active site using in silico approaches, (ii) lasB proteolytic activity by using a specific fluorogenic peptide substrate, (iii) lasB gene expression by real time-polymerase chain …


Visceral Adipose Tissue Modulates Radiosensitivity In Oesophageal Adenocarcinoma, Ann Marie Mongan, Niamh Lynam-Lennon, Suzanne Doyle, Rory Casey, Eibhlin Carr, Aoife Cannon, Melissa J Conroy, Graham P Pidgeon, Lorraine Brennan, Joanne Lysaght, John V. Reynolds, Jacintha O’Sullivan Jan 2019

Visceral Adipose Tissue Modulates Radiosensitivity In Oesophageal Adenocarcinoma, Ann Marie Mongan, Niamh Lynam-Lennon, Suzanne Doyle, Rory Casey, Eibhlin Carr, Aoife Cannon, Melissa J Conroy, Graham P Pidgeon, Lorraine Brennan, Joanne Lysaght, John V. Reynolds, Jacintha O’Sullivan

Articles

Oesophageal adenocarcinoma (OAC) is an exemplar model of obesity-associated cancer. Response to neoadjuvant chemoradiotherapy (NA CRT) is a clinical challenge. We examined if visceral adipose tissue and obesity status alter radiosensitivity in OAC. The radioresistant (OE33R) and radioresponsive (OE33P) OAC isogenic model was cultured with adipose tissue conditioned media from three patient cohorts: non-cancer patients, surgery only OAC patients and NA CRT OAC patients. Cell survival was characterised by clonogenic assay, metabolomic profiling by nuclear magnetic resonance spectroscopy and adipokine receptor gene expression by qPCR. A retrospective in vivo study compared tumour response to NA CRT in normal weight (n=53) …


The Relationship Between Maternal Plasma Homocysteine In Early Pregnancy And Birth Weight, Shona Cawley, Eimer O'Malley, Rachel Kennedy, Ciara Reynolds, Anne Molloy, Michael Turner Jan 2019

The Relationship Between Maternal Plasma Homocysteine In Early Pregnancy And Birth Weight, Shona Cawley, Eimer O'Malley, Rachel Kennedy, Ciara Reynolds, Anne Molloy, Michael Turner

Articles

Background: There is limited evidence that plasma homocysteine (Hcy) is increased in women with adverse pregnancy outcomes, such as low birth weight (LBW).

Objective: We examined the relationship between maternal Hcy at the first prenatal visit and birth weight.

Study design: In a prospective observational study, women were recruited during their first prenatal visit after sonographic confirmation of gestational age. Along with the standard tests, blood was also taken for the measurement of maternal serum and red blood cell (RBC) folate, vitamin B12, and Hcy. In addition to collecting standard clinical and sociodemographic details, a detailed questionnaire on vitamin supplementation …


A Web-Based Dietary Intervention In Early Pregnancy And Neonatal Outcomes: A Randomized Controlled Trial, Rachel Ak Kennedy, C.M.E. Reynolds, Shona Cawley, E. O'Malley, D.M. Mccartney, M.J. Turner Jan 2019

A Web-Based Dietary Intervention In Early Pregnancy And Neonatal Outcomes: A Randomized Controlled Trial, Rachel Ak Kennedy, C.M.E. Reynolds, Shona Cawley, E. O'Malley, D.M. Mccartney, M.J. Turner

Articles

Background Maternal nutrition is a determinant of pregnancy outcomes. Few studies have evaluated the potential of online nutrition resources to modify behaviour. This randomized controlled trial aimed to determine whether access to a customized evidence-based nutrition website in pregnancy improved neonatal outcomes.

Methods Women < 18 weeks gestation were recruited at their convenience. The control group received standard care. In addition to standard care, the intervention group received access to an evidence-based nutrition website, customized to the preferences of pregnant women.

Results Of the 250 women, there were no differences in characteristics between the two groups. Of the women, 91.0% reported they make a conscious effort currently to eat a healthy diet. However, only 19.6% met dietary requirements for calcium, 13.2% for iron, 2.7% for folate and 2.3% for iodine. The most popular website section was pregnancy …