Digital Commons Network^™

Numerically Modelling Time And Dose Dependent Cytotoxicity, Hugh Byrne, Marcus A. Maher

Articles

Dose-response curves are fundamental tools of in vitro toxicology, extensively employed in toxicant or drug screening. They are expressed by a variety of end-points and assays, measured at different time-points in a choice of cell-lines, but are typically quantified only using the mean concentration for 50% response (e.g. drug efficacy or pathway inhibition) as an indicator of overall effect. However, the response is the result of a complex and dynamic cascade of events which occur between the initial exposure and the measured end-point, and the characteristic rates of the contributing stages govern the dose response and ultimately the measured characteristic …

Permitted Incentives For Workplace Wellness Plans Under The Ada And Gina: The Regulatory Gap, Elizabeth Pendo

Articles

Although workplace wellness plans have been around for decades, they have flourished under the Patient Protection and Affordable Care Act (“PPACA”) into a $6 billion-dollar industry. Under PPACA, a “wellness plan” is a program of health promotion or disease prevention offered by an employer that is designed to promote health or prevent disease and which meets the other applicable requirements of that subsection. Employers look to these programs to promote healthy lifestyles, improve the overall health of employees and beneficiaries, and reduce rising healthcare costs.

PPACA’s amendments to the Health Insurance Portability and Accountability Act (“HIPAA”) permit employers to offer …

Thermostable Phytase In Feed And Fuel Industries, Ushasree Mrudula Vasudevan, Amit Jaiswal, Shyam Krishna, Ashok Pandey

Articles

Phytase with wide ranging biochemical properties has long been utilized in a multitude of industries, even so, thermostability plays a crucial factor in choosing the right phytase in a few of the sectors. Mesophilic phytases are not considered to be a viable option in the feed industry owing to its limited stability in the required feed processing temperature. In the recent past, inclusion of thermostable phytase in fuel ethanol production from starch based raw material has been demonstrated with economic benefits. Therefore, considerable emphasis has been placed on using complementary approaches such as mining of extremophilic microbial wealth, encapsulation and …

Feigned Consensus: Usurping The Law In Shaken Baby Syndrome/Abusive Head Trauma Prosecutions, Keith A. Findlay, D. Michael Risinger, Patrick D. Barnes, Julie A. Mack, David A. Moran, Barry Scheck, Thomas L. Bohan

Articles

Few medico-legal matters have generated as much controversy-both in the medical literature and in the courtroom-as Shaken Baby Syndrome (SBS), now known more broadly as Abusive Head Trauma (AHT). The controversies are of enormous significance in the law because child abuse pediatricians claim, on the basis of a few non-specific medical findings supported by a weak and methodologically flawed research base, to be able to "diagnose" child abuse, and thereby to provide all of the evidence necessary to satisfy all of the legal elements for criminal prosecution (or removal of children from their parents). It is a matter, therefore, in …

Groundwater Resources As A Global Reservoir For Antimicrobial-Resistant Bacteria, Luisa Andrade, Madeleine Kelly, Paul Hynds, John Weatherill, Anna Majury, Jean O'Dwyer

Articles

Antimicrobial resistance represents one of our most significant global health threats, with increasing incidences noted in both clinical and environmental settings. As such, identifying and understanding the sources and pathways for antimicrobial-resistant bacteria (ARB) is critical. The current study presents the first systematic review and pooled analysis of ARB occurrence in global groundwater supplies, which are used as primary drinking water sources by 2.2 billion people worldwide and are recurrently linked to significant outbreaks of infection. Seventy peer-reviewed studies were identified and included; findings reveal that 80.2% ± 29.0 and 57.2% ± 36.8 of aggregated groundwater isolates were resistant to …

Evaluation Of Hydrometric Network Efficacy And User Requirements In The Republic Of Ireland Via Expert Opinion And Statistical Analysis, Paul Hynds, Ahmed Nasr, Jean O'Dwyer

Articles

Decreased funding and shifting governmental priorities have resulted in a contraction of hydrometric measurement in many regions over the past two decades. Moreover, concerns exist with respect to appropriate data usage and (transboundary) exchange, in addition to the compatibility and extent of existing hydrometric datasets. These issues are undoubtedly magnified due to enhanced data demands and increased financial pressures on network managers, thus requiring new approaches to optimising the societal benefits and overall efficacy of hydrometric information for future socio-hydrological resilience. The current study employed a quantitative cross-sectional expert elicitation of 203 respondents to collate, analyse and assess hydrometric network …

Commercial Speech Protection As Consumer Protection, Felix T. Wu

Articles

The Supreme Court has long said that “the extension of First Amendment protection to commercial speech is justified principally by the value to consumers of the information such speech provides.” In other words, consumers—the recipients or listeners of commercial speech—are the ones the doctrine is meant to protect. In previous work, I explored the implications of taking this view seriously in three contexts: compelled speech, speech among commercial entities, and unwanted marketing. In each of those contexts, adopting a listener-oriented approach leads to the conclusion that many forms of commercial speech regulation should receive far less First Amendment scrutiny than …

Caring For The Care‐Giver: Debriefing Following Intra‐Operative Death, Roy Soto, Julie Kado, Bryan Kerner, Paul O’Leary, Gerald Rosen

Articles

Introduction: Intraoperative death affects a team of individuals, each with different levels of training and experience. Although briefings, time-outs, and debriefings have been well described, it is unclear how often they occur following intraoperative catastrophic events. We utilized an electronic survey to assess the frequency and potential utility of a formal debriefing process following the intraoperative death of a patient, and discuss our findings in light of the mental well-being of perioperative medical personnel. Methods:A 19 question electronic survey was distributed to primary operating room staff in two hospital systems. The survey was designed to identify which OR staff members …

Coastal Dune Vegetation Mapping Using A Multispectral Sensor Mounted On An Uas, Chen Suo, Eugene Mcgovern, Alan Gilmer

Articles

Vegetation mapping, identifying the type and distribution of plant species, is important for analysing vegetation dynamics, quantifying spatial patterns of vegetation evolution, analysing the effectsof environmental changes and predicting spatial patterns of species diversity. Such analysis can contribute to the development of targeted land management actions that maintain biodiversity and ecological functions. This paper presents a methodology for 3D vegetation mapping of a coastal dune complex using a multispectral camera mounted on an unmanned aerial system with particular reference to the Buckroney dune complex in Co. Wicklow, Ireland. Unmanned aerial systems (UAS), also known as unmanned aerial vehicles (UAV) or …

Emotional Intelligence And Conflict Management Styles, Helen Chen, Xuemei Xu, Patrick Phillips

Articles

Purpose – This paper aims to use a multi-level approach to examine the effects of emotional intelligence (EI) components on conflict management styles of Chinese managers when the respondents were in conflicts with their subordinates, peers or superiors.

Design/methodology/approach – The primary research was conducted in Dalian, China, via a personal survey resulting in 885 usable observations for analysis. EI was measured using the Wong and Law Emotional Intelligence Scale (WLEIS; Wong and Law, 2002), which is made up of 16 questions measuring four dimensions. The conflict management component was measured via Rahim’s (1983) five conflict management styles, which are …

Predicting Quality Attributes And Waste Of Strawberry Packed Under Modified Atmosphere Throughout The Cold Chain, Kompal Johsi, Brijesh Tiwari, Patrick J. Cullen, Jesus Maria Frias

Articles

Modified Atmosphere Packaging (MAP) is used commercially to extend the shelf life of strawberries. The attainment of desired gas (O2, CO2) concentrations inside MAP relies on the product respiration and the mass transfer through packaging and will affect the quality. The objective of this work is to build a mathematical model for strawberries to assess the effect of the uncertainties on headspace gas concentration and quality: 1) cold chain related temperature and relative humidity variations and 2) variability associated to product respiration and quality based on literature. Weight loss was more influenced by the cold chain storage conditions (temperature and …

Towards A Learning System For University Campuses As Living Labs For Sustainability, L.A. Verhoef, M. Bossert, J. Newman, Filipa Ferraz, Z.P. Robinson, Y. Agarwala, P. Wolff, P. Jiranek, C. Hellinga

Articles

Universities, due to their sizeable estates and populations of staff and students, as well as their connections with, and impact within, their local and wider communities, have significant environmental, social and economic impacts. There is a strong movement for universities to become leaders in driving society towards a more sustainable future, through improving the sustainability of the built environment and the universities’ practices and operations, and through their educational, research and wider community engagement missions. Around the globe the concept of ‘Living Labs’ has emerged as an instrument to integrate these different aspects to deliver sustainability improvements, through engaging multiple …

Nuclear Frames In The Irish Media: Implications For Conversations On Nuclear Power Generation In The Age Of Climate Change, Catherine Devitt, Finbarr Brereton, Simon Mooney, David Conway, Eoin O'Neill

Articles

Keeping within the temperature limits set by the Paris Agreement on climate action will be a significant challenge. Nuclear power generation may contribute to achieving these targets, however, there are significant environmental, economic and health risks attached. Using qualitative and quantitative methods, this paper explores how nuclear power generation is framed in the Irish print media, and discusses the implications of these frames for how nuclear power is perceived within the context of climate change mitigation in Ireland. Two Irish broadsheet papers, the Irish Times and the Irish Independent were selected for data collection, focusing on Chernobyl and Fukushima incidents. …

Luminescent Calcium Carbonate Micro ‘Bow Ties’, Fearghal C. Donnelly, Finn Purcell-Milton, Peter W. Dunne, Aleksandra Rulikowska, Victor Alguacil, Yurii K. Gun’Ko

Articles

Calcium carbonate (CaCO3) is a ubiquitous material which has been studied for centuries due to its integral nature across various fields and its vast range of applications. Here we report, for the first time, a low temperature dry ice carbonation method for the production of unique rare earth-doped calcium carbonate ‘bow ties’. CaCO3 exhibits retrograde solubility, an interesting property in which its solubility increases with decreasing temperature. In this synthesis, dry ice acts not only as a CO2 source, but as a coolant, increasing the solubility of CaCO3 and CO2 and allowing specific growth to occur. The incorporation of trivalent …

Harnessing Smart Technology For Private Well Risk Assessment And Communication, Tanner Hoffman, Paul Hynds, Corinne Schuster-Wallace, Sarah Dickson-Anderson, Anna Majury

Articles

Unregulated, privately owned water supplies, including groundwater wells, are relied upon extensively, particularly in rural and remote regions. While adequate stewardship behaviors (water testing, treatment, and maintenance) have been shown to decrease the incidence and frequency of faecal indicator organism (FIO) presence and, by extension, the risk of pathogenic ingress, contaminated private water supplies continue to constitute a significant public health risk. Recognizing that innovative approaches are needed to bolster well stewardship, this paper identifies and assesses 35 tools (smartphone and web-based applications) to better understand components, functionality, strengths, and weaknesses. Applications for both data collection and risk communication were …

Predicting Quality Attributes Of Strawberry Packed Under Modified Atmosphere Throughout The Cold Chain, Kompal Joshi, Brijesh Tiwari, P. J. Cullen, Jesus Maria Frias

Articles

Modified Atmosphere Packaging (MAP) is used commercially to extend the shelf life of strawberries. The attainment of desired gas (O2, CO2) concentrations inside MAP relies on the product respiration and the mass transfer through packaging and will affect the quality. The objective of this work is to build a mathematical model for strawberries to assess the effect of the uncertainties on headspace gas concentration and quality: 1) cold chain related temperature and relative humidity variations and 2) variability associated to product respiration and quality based on literature. Weight loss was more influenced by the cold chain storage conditions (temperature and …

Carbon Dioxide Measurement In Irish Blanket Peatlands: An Assessment Of Pool-Soil Flux Variability, Mariya Radomski, Alan Gilmer, Vivienne Byers, Eugene Mcgovern

Articles

Peatlands have been recognised as having a significant role in the mediation of atmospheric carbon dioxide (CO2) levels with direct implications for global climate change. Longitudinal in situ measurement systems for CO2 concentrations in blanket peatland ecosystems are difficult to implement where the nature of terrestrial–aquatic connectivity and hydrodynamics have a significant effect on the carbon cycle. The need for greater data on CO2 concentrations and flux monitoring in these settings has been well recognised. However, applying the most appropriate monitoring approach presents a special challenge. This paper sets out the development of a direct method for field based longitudinal …

Assessment Of Physicochemical Characteristics, Thermal Stability And Release Profile Of Ascorbic Acid Microcapsules Obtained By Complex Coacervation, Michele Cristina Rodrigues Da Cruz, João Luiz Andreotti Dagostin, Camila Augusto Perussello, Maria Lúcia Masson

Articles

The aim of this study was to determine the physicochemical characteristics, thermal stability and release profile of ascorbic acid (AA) microcapsules obtained by complex coacervation. Gelatin and gum arabic were used as wall materials in concentrations of 2.5, 5.0 and 7.5 g% (w/v). The coacervate microcapsules were freeze-dried and assessed for physicochemical characteristics, thermal behavior and stability during 60 days of storage. The release profile was evaluated at different pH values (1.1, 2.2, 5.4, 7.4, 9.6 and 12). The encapsulation efficiency ranged from 27.3 to 93.8%. The microcapsules of AA presented good characteristics for application in food matrices, such as …

A Review Of Co2 Emission Reductions Due To Wind Turbines Using Energy Benchmarks: A Focus On The Irish Electrical Energy Market, Tony Kealy

Articles

The installed capacity of wind turbines in Ireland increased from a value of 2,250 MW in 2014 to 3,318 MW in 2017, a 43% increase in the four years, supported through climate mitigation policies. The main aim of this study is to determine if the increase in wind turbine installed capacity is impacting on efforts to reduce CO2 emissions. The study utilises a review methodology. The findings show that the steady rise in wind turbine installed capacity year-on-year is not reflected in the Irish CO2 g/kWh energy benchmark. The benchmark value was 457 g CO2/kWh in 2014 and 437 g …

Rapid Fabrication Of Silver Nanoparticle/Polydopamine Functionalized Polyester Fibers, Yanfen Zhou, Liang Jiang, Ya Guo, Zhenhua Sun, Zhiqing Jiang, Shaojuan Chen, Jianwei Ma, Stephen Jerrams

Articles

In this paper, silver nanoparticles functionalized poly(ethylene terephthalate) (PET) fibers with antimicrobial activity, electrical conductivity and good coating stability are reported. Firstly, silver plated PET fibers were fabricated by rapid polydopamine (PDA) modification followed by electroless plating. Secondly, the surface morphologies and compositions of PDA modified and silver coated PET fibers were characterized by employing scanning electron microscopy, atomic force microscopy, X-ray diffraction and energy dispersive spectrometry. Finally, the antimicrobial properties and electrical conductivity of the silver plated PET fibers were investigated. The results showed that the silver coated PET fibers exhibited excellent antimicrobial activity to both Escherichia coli and …

Spirit Checklist, Myopia Outcome Study Of Atropine In Children (Mosaic): Design And Methodology, Saoirse Mccrann, Daniel Ian Flitcroft, John S. Butler, James Loughman

Articles

Purpose

The Myopia Outcome Study of Atropine in Children (MOSAIC) aims to explore the efficacy, safety, acceptability and mechanisms of action of 0.01% atropine for myopia control in a European population.

Methods

MOSAIC is an investigator-led, double-masked, placebo-controlled, randomised clinical trial (RCT) investigating the efficacy, safety and mechanisms of action of 0.01% atropine in myopia progression management. During Phase 1 of the trial, 250 children aged 6-16 years with progressive myopia apply eye drops once nightly in both eyes from randomisation to month 24. No treatment is given during Phase 2 from month 24 to 36 (washout period) for those …

Un(Der)Employed Youth: From Precariousness To Resilience, Alia Weston, Miguel Imas, Jennifer Manning, Paul Donnelly, Kudzayi Ngwerume

Articles

In this paper, we explore the experiences of Irish and Zimbabwean youth who live and work in precarious economic conditions. We study these youths’ experiences in a manner that traverses contexts under the question: How do un(der)employed youth in the Global South and Global North enact resilience and agency while navigating economic precarity? The paper builds on youth literature from both the Global North and Global South, emphasizing socio-economic precarity, youth agency, and resilience. We collected our data from interviews conducted in Ireland and Zimbabwe. Methodologically, the paper follows a postcolonial narrative approach to study these experiences. Our findings show …

Men And The Drug Buzz: Masculinity And Men’S Motivations For Illicit Recreational Drug Use, Clay Darcy

Articles

The purpose of this article is to explore the motivations behind some men’s recreational use of illicit drugs from a gender standpoint. The rationale for this analysis stems from men’s predominance as illicit drug users and their likelihood of experiencing problem drug use and becoming a part of an over-represented population in drug treatment services. Explanations for men’s problematic/addicted patterns of drug use often point to marginalisation, disadvantage, and/or men’s tendency towards problematic health behaviours. This article argues that men’s illicit recreational drug use is often glossed over as a gendered activity and receives less scrutiny than problematic/addicted patterns of …

Applying The Practice–Based Method In Teaching Entrepreneurship: The Case Of The Msc In Business & Entrepreneurship At Tu Dublin, Anthony Paul Buckley

Articles

‘Since we live in an age of innovation, a practical education must prepare a [wo]man for work that does not yet exist and cannot yet be clearly defined’ - Peter Drucker Following reviews of the relevant IEET (Innovation, Entrepreneurship Education & Training) literature and after assessing current thinking and practice in the domain, it was concluded that, in the absence of empirical evidence in favour of a particular pedagogical approach, that a portfolio of coordinated practice-based methods is an appropriate approach for developing value-based learning outcomes at this time (2019). These pedagogical approaches focus on students’ attempts to discover, create …

Emerging Food Processing Technologies And Factors Impacting Their Industrial Adoption, Anushree Priyadarshini, Gaurav Rajauria, Colm. P. O'Donnell, Brijesh K. Tiwari

Articles

Innovative food processing technologies have been widely investigated in food processing research in recent years. These technologies offer key advantages for advancing the preservation and quality of conventional foods, for combatting the growing challenges posed by globalization, increased competitive pressures and diverse consumer demands. However, there is a need to increase the level of adoption of novel technologies to ensure the potential benefits of these technologies are exploited more by the food industry. This review outlines emerging thermal and non-thermal food processing technologies with regard to their mechanisms, applications and commercial aspects. The level of adoption of novel food processing …

The Battle For Commercial Hearts And Minds And The Internal Brand Within A Charity Shop Network In Ireland, Edmund O'Callaghan

Articles

Charities are increasingly adopting commercial branding strategies to capture consumer hearts and minds for competitive gain, with little attention on the internal organisational battle for hearts and minds within a not-for-profit context. This paper explores the internal brand of a charity that currently operates 227 charity shops on the island of Ireland, using Hankinson’s 2004 framework that focuses on functional, symbolic, behavioural and experiential components. An exploratory case study was developed based on a survey of organisational members (n = 138), interviews with six regional shopmanagers, observation in retail stores and supplemented by organisation documentation. Findings indicate a clarity of …

Lutein And Zeaxanthin: The Possible Contribution, Mechanisms Of Action And Implications Of Modern Dietary Intake For Cognitive Development In Children. [Version 1; Peer Review: 2 Approved], Ekaterina Loskutova, Kajal Shah, Daniel Ian Flitcroft, Annalisa Setti, John Butler, Yvonne Nolan, Nabin Paudel, James Loughman

Articles

No abstract provided.

Is Optometry Ready For Myopia Control? Education And Other Barriers To The Treatment Of Myopia, Saoirse Mccrann, Daniel Ian Flitcroft, James Loughman

Articles

Background: With the increasing prevalence of myopia there is growing interest in active myopia control. However, the majority of progressive myopes are still prescribed single vision spectacles. This prospective study aims to elucidate the knowledge and attitudes of optometrists toward myopia control, and thereby identify perceived barriers to the implementation of a risk focussed model of myopia management.

Implementing A Two-Tiered Model Of Optometry Training In Mozambique As An Eye Health Development Strategy, Diane Van Staden, James Loughman, Kovin Naidoo

Articles

Background: The global burden of vision impairment has been acknowledged by the World Health Organisation as a public health challenge. In order to scale up the production of eye health personnel in developing countries, a tiered model of optometry training was explored in Mozambique.

Identification Of Surrogate Biomarkers For The Prediction Of Patients At Risk Of Low Macular Pigment In Type 2 Diabetes, Grainne Scanlon, Daniel Mccartney, John Butler, Ekaterina Loskutova, James Loughman

Articles

Purpose: This cross-sectional study compared macular pigment (MP) levels among persons with Type 2 diabetes relative to healthy controls. Additionally, a range of behavioral, anthropometric, clinical and serum measures were explored as possible predictors of low MP optical density (MPOD) in diabetes.