Digital Commons Network^™

Before The Cell Door Shuts: Justice Reform Efforts Should Focus On Steps Besides Sentencing, Barbara L. Mcquade

Articles

Mark Osler writes that criminal justice reform efforts have been hampered by what he calls “the slows.” He explains that despite bipartisan support, which resulted in the First Step Act of 2018,2 criminal justice reform remains elusive. He then offers some insightful suggestions for how to increase the pace.

The Spatial Frequency Content Of Urban And Indoor Environments As A Potential Risk Factor For Myopia Development, Daniel Ian Flitcroft, Elise Harb, Christine F Wildsoet

Articles

To examine the hypothesis that the spatial frequency spectra of urban and indoor environments differ from the natural environment in ways that may promote the development of myopia. Methods: A total of 814 images were analyzed from three datasets; University of California Berkeley (UCB), University of Texas (UT), and Botswana (UPenn). Images were processed in Matlab (Mathworks Inc) to map the camera color characteristics to human cone sensitivities. From the photopic luminance images generated, two-dimensional spatial frequency (SF) spectra were calculated and converted to one-dimensional spectra by rotational averaging. The spatial filtering profile of a 0.4 Bangerter foil, which has …

Macular Pigment Optical Density Fluctuation As A Function Of Pupillary Mydriasis: Methodological Considerations For Dual-Wavelength Autofluorescence, Ekaterina Loskutova, John Butler, Gabriela Hernandez-Martinez, Daniel Ian Flitcroft, James Loughman

Articles

Macular pigment (MP), comprising the dietary carotenoids lutein, zeaxanthin and meso-zeaxanthin, is believed to benefit eye health and vision. Numerous clinical and research devices and techniques are currently available to facilitate MP optical density (MPOD) measurement. One of those techniques, dual-wavelength fundus autofluorescence (AF) is being increasingly used for measurement of MP in the eye. There is substantial methodological variation across the published studies that have employed this technique, including in relation to the use of mydriasis, the possible influence of which does not appear to have been addressed in the literature. This prospective cross-sectional study was designed to investigate …

On The Intermediate Long Wave Propagation For Internal Waves In The Presence Of Currents, Joseph Cullen, Rossen Ivanov

Articles

A model for the wave motion of an internal wave in the presence of current in the case of intermediate long wave approximation is studied. The lower layer is considerably deeper, with a higher density than the upper layer. The flat surface approximation is assumed. The fluids are incompressible and inviscid. The model equations are obtained from the Hamiltonian formulation of the dynamics in the presence of a depth-varying current. It is shown that an appropriate scaling leads to the integrable Intermediate Long Wave Equation (ILWE). Two limits of the ILWE leading to the integrable Benjamin-Ono and KdV equations are …

Camassa-Holm Cuspons, Solitons And Their Interactions Via The Dressing Method, Rossen Ivanov, Tony Lyons, Nigel Orr

Articles

A dressing method is applied to a matrix Lax pair for the Camassa–Holm equation, thereby allowing for the construction of several global solutions of the system. In particular, solutions of system of soliton and cuspon type are constructed explicitly. The interactions between soliton and cuspon solutions of the system are investigated. The geometric aspects of the Camassa–Holm equation are re-examined in terms of quantities which can be explicitly constructed via the inverse scattering method.

Dynamic Blood-Brain Barrier Regulation In Mild Traumatic Brain Injury, Eoin O'Keeffe, Eoin Kelly, Yuzhe Liu, Chiara Giordano, Eugene Wallace, Mark Hynes, Stephen Tiernan, Aidan Meagher, Chris Greene, Stephanie Hughes, Tom Burke, John Kealy, Niamh Doyle, Alison Hay, Michael Farrell, Gerald A. Grant, Alon Friedman, Ronel Veksler, Michael G. Molloy, James F. Meaney, Niall Pender, David Camarillo, Colin P. Doherty, Matthew Campbell

Articles

Whereas the diagnosis of moderate and severe traumatic brain injury (TBI) is readily visible on current medical imaging paradigms (magnetic resonance imaging [MRI] and computed tomography [CT] scanning), a far greater challenge is associated with the diagnosis and subsequent management of mild TBI (mTBI), especially concussion which, by definition, is characterized by a normal CT. To investigate whether the integrity of the blood-brain barrier (BBB) is altered in a high-risk population for concussions, we studied professional mixed martial arts (MMA) fighters and adolescent rugby players. Additionally, we performed the linear regression between the BBB disruption defined by increased gadolinium contrast …

Interest Rate Volatility And Macroeconomic Dynamics: Heterogeneity Matters, Michael Curran, Adnan Velic

Articles

We examine the relation between real interest rate volatility and aggregate fluctuations for a diverse sample of countries. Compiling a new dataset including emerging and advanced countries, the substantial variation in our data yields novel results: (a) stochastic volatility outperforms Markovswitching in representing interest rates, (b) some advanced economies can be more volatile than emerging markets, and (c) creditors take on more debt following volatility shocks. We show how an equilibrium business cycle model with uncertainty shocks can generate these facts. Sample heterogeneity produces significant parameter differences, playing an important role in distinguishing the effects of volatility shocks.

The Capm, National Stock Market Betas, And Macroeconomic Covariates: A Global Analysis, Michael Curran, Adnan Velic

Articles

Using global data on aggregate stock markets, this paper finds that the capital asset pricing model fares much better than suggested previously. At shorter time horizons, our results also show that the positive risk-reward relation can collapse during times of high volatility. Compared to other countries, we retrieve evidence of lower systematic risks across frontier equity portfolios. We find that countries characterized by higher levels of openness, exchange rate volatility, and larger economic size are exposed to higher systematic covariances with the world stock market. Conversely, we obtain an inverse link between international reserves and systematic risks in national equity.

Stability Analysis Of Einstein's Universe In Loop Quantum Cosmology, Eamon Mccaughey

Articles

A stability analysis of Einstein’s universe in both classical General Relativity and semiclassical Loop Quantum Cosmology regimes is presented. The stability properties of the General Relativity model are significantly altered due to Loop Quantum Gravity corrections. Comparisons between both dynamical systems are considered on the basis of these modifications. The Loop Quantum Cosmology solutions are restricted to an open universe model (k = -1) and represent a cyclic universe. The integrals of motion for both systems are found and their Hamiltonian structure determined.

Biopharmaceutical Revolution In Saudi Arabia: Progress And Development, Rihana Alzahran, Elaine Harris

Articles

Purpose This paper aimed to analyze the situation of the biopharmaceutical industry in Saudi Arabia to improve the situation in a way that achieves high levels of development similar to those in Europe, the United States of America (USA), and Japan. Methods To achieve the objective of the study, the authors surveyed 18 out of 21 Saudi pharmaceutical companies that have received licensing for manufacturing from the Saudi Food and Drug Authority (SFDA) to diagnose the situation of manufacturing in relation to biopharmaceuticals. An interview with SFDA officials was carried out as a supplement to the survey. Results Findings revealed …

Can Protanopia Be Correctly Diagnosed In Clinical Practice? An Evaluation Of Diagnosis By Four Screening Tests, Peter Davison, Grainne Scanlon

Articles

SIGNIFICANCE

Protanopia is a color vision deficiency (CVD) that is unacceptable for certain occupations. This study compares simultaneously for the first time the ability of three recently revised or developed clinical tests of color vision with the Ishihara test to diagnose protanopia from other color vision deficiencies.

PURPOSE

The objectives were to examine the ability of four clinical tests to differentiate (1) between protan and deutan CVDs in patients with protanopia and deuteranopia, and (2) protanopes and deuteranopes as “strong” deficiencies.

METHODS

The Hardy-Rand-Rittler (4th ed.), City University (3rd ed.), Ishihara, and Mollon-Reffin tests were evaluated against the Oculus Heidelberg …

An Empirical Evaluation Of The Inferential Capacity Of Defeasible Argumentation, Non-Monotonic Fuzzy Reasoning And Expert Systems, Lucas Rizzo, Luca Longo

Articles

Several non-monotonic formalisms exist in the field of Artificial Intelligence for reasoning under uncertainty. Many of these are deductive and knowledge-driven, and also employ procedural and semi-declarative techniques for inferential purposes. Nonetheless, limited work exist for the comparison across distinct techniques and in particular the examination of their inferential capacity. Thus, this paper focuses on a comparison of three knowledge-driven approaches employed for non-monotonic reasoning, namely expert systems, fuzzy reasoning and defeasible argumentation. A knowledge-representation and reasoning problem has been selected: modelling and assessing mental workload. This is an ill-defined construct, and its formalisation can be seen as a reasoning …

Ambiqual: Towards A Quality Metric For Headphone Rendered Compressed Ambisonic Spatial Audio, Miroslaw Narbutt, Jan Skoglund, Andrew Allen, Michael Chinen, Dan Barry, Andrew Hines

Articles

Spatial audio is essential for creating a sense of immersion in virtual environments. Efficient encoding methods are required to deliver spatial audio over networks without compromising Quality of Service (QoS). Streaming service providers such as YouTube typically transcode content into various bit rates and need a perceptually relevant audio quality metric to monitor users’ perceived quality and spatial localization accuracy. The aim of the paper is two-fold. First, it is to investigate the effect of Opus codec compression on the quality of spatial audio as perceived by listeners using subjective listening tests. Secondly, it is to introduce AMBIQUAL, a full …

Quantification And Identification Of Microproteinuria Using Ultrafiltration And Atr-Ftir Spectroscopy, David Perezguaita, Zack Richardson, Phil Heraud, Bayden Wood

Articles

The presence of low amounts of specific proteins in urine can be an indicator of diagnosis and prognosis of several diseases including renal failure and cancer. Hence, there is an urgent need for Point-of-care (PoC) methods, which can quantify microproteinuria levels (30-300 ppm) and identify the major proteins associated with the microproteinuria. In this study, we coupled ultracentrifugation with attenuated total reflectance-Fourier transform infrared (ATR-FTIR) to identify and quantify proteins in urine at low parts per million levels. The process involves the preconcentration of proteins from 500 μL of urine using an ultrafiltration device. After several washings, the isolated proteins …

Determining The Age Of Spoiled Milk From Dried Films Using Attenuated Reflection Fourier Transform Infrared (Atr Ft-Ir) Spectroscopy, Zack Richardson, David Perezguaita, Kamila Kochan, Bayden Wood

Articles

Milk spoilage is an inevitable occurrence, which generates waste and can result in food poisoning. When milk spoils, the off-flavor and curdling are due to excessive proliferation of various bacteria which causes pH changes. Time, temperature, environment,and previous handling practice all affects the spoilage rate. There is a need for a fast reliable and accurate method that can identify in situearly spoilage of milk. Here we show the ability of attenuated total reflectionFourier transformed infrared spectroscopy(ATR FT-IR) in conjunction with multivariate data analysis to predict the age of milk. We found that dried films vastly increased the absorbance of important …

Mapping (In)Equity At The Polls, Brianne Gilbert, Max Dunsker

Articles

While provisions of the 1965 federal Voting Rights Act continue to guarantee equal voting rights, a fundamental question remains: do all citizens enjoy equal access to the ballot box? Anecdotally, we know that not everyone has equal access, yet where do these differences exist spatially, are there trends, and how can students make an impact? This overarching lesson plan creates a set of lessons for students to determine a list of vote location characteristics, collect data at the polls, and analyze the data to answer these questions, opening the doors to many more questions as well. Included in the lesson …

Regulatory Responses To Medical Machine Learning, Timo Minssen, Sara Gerke, Mateo Aboy, W. Nicholson Price Ii, Glenn Cohen

Articles

Companies and healthcare providers are developing and implementing new applications of medical artificial intelligence, including the artificial intelligence sub-type of medical machine learning (MML).MML is based on the application of machine learning (ML) algorithms to automatically identify patterns and act on medical data to guide clinical decisions. MML poses challenges and raises important questions, including (1) How will regulators evaluate MML-based medical devices to ensure their safety and effectiveness? and (2) What additional MML considerations should be taken into account in the international context? To address these questions, we analyze the current regulatory approaches to MML in the USA and …

International Law And Theories Of Global Justice: Remarks, Steven R. Ratner, James Stewart, Jiewuh Song, Carmen Pavel

Articles

International law (IL) and political philosophy represent two rich disciplines for exploring issues of global justice. At their core, each seeks to build a better world based on some universally agreed norms, rules, and practices, backed by effective institutions. International lawyers, even the most positivist of them, have some underlying assumptions about a just world order that predisposes their interpretive methods; legal scholars have incorporated concepts of justice in their work even as their overall pragmatic orientation has limited the nature of their inquiries. Many philospophers, for their part, have engaged with IL to some extent—at a minimum recognizing that …

What Litigators Can Learn From B Movies, Leonard M. Niehoff

Articles

We litigators take our guidance when and where we can find it. Sometimes we stumble across it very late at night, on television. Weary, intellectually spent, and pining for entertainment that makes no demands on us, in "the wee small hours of the morning" we find ourselves watching a so-called B movie - a film that had a low production budget or that manages to be bad despite an ample one. And, lo, enlightenment ensues through this unlikeliest of messengers. Submitted for your consideration are some gems from half a dozen movies that most sensible people won't admit watching but …

Muted Justice, Leah Litman

Articles

The Chief Justice of the United States possesses significant power. His position as the senior most Justice on the U.S. Supreme Court allows him to assign opinions to other Justices and to coordinate scheduling the Court’s cases for argument. And after Justice Kennedy retired in June 2018, Chief Justice Roberts was the median Justice on the Court, whose vote often determined the outcome in a case. Even after Justice Barrett’s confirmation changed that state of affairs, the Chief remains an important Justice to watch.

When Mini-Publics And Maxi-Publics Coincide: Ireland’S National Debate On Abortion, David M. Farrell, Jane Suiter, Kevin Cunningham, Clodagh Harris

Articles

Ireland’s Citizens’ Assembly (CA) of 2016–18 was tasked with making recommendations on abortion. This paper shows that from the outset its members were in large part in favour of the liberalisation of abortion (though a fair proportion were undecided), that over the course of its deliberations the CA as a whole moved in a more liberal direction on the issue, but that its position was largely reflected in the subsequent referendum vote by the population as a whole.

A Comparison Of Radiobiological Response In Cells Exposed To Low Let Radiation With Different Beam Energies, Lisa White, Laura Shields, Orla Howe, Isabel Vega Carrascal, Adrian Maguire, Aidan Meade, Brendan Mcclean, Fiona M. Lyng

Articles

There is conflicting evidence in the literature on biological effects between different low LET radiations. The aim of this study was to investigate the impact of different low LET radiations on radiobiological response. Chromosomal radiosensitivity was measured in human lymphocytes from healthy donors using the G2 chromosomal radiosensitivity assay. Radiation induced mitotic inhibition was also measured. Cells were irradiated to doses of 0.05 and 0.5 Gy using a Cobalt 60 teletherapy unit and a Linac operating at 6 MV (photons) and 12 MeV (electrons). As expected, a dose response was observed with increasing dose resulting in greater response. No statistically …

Performing The Digital Self: Understanding Location-Based Social Networking, Territory, Space, And Identity In The City, Konstantinos Papangelis, Alan Chamberlain, Ioanna Lykourentzou, Vassilis-Javed Khan, Michael Saker, Hai-Ning Liang, Irwyn Sadien, Ting Cao

Articles

Expressions of territoriality have been positioned as one of the main reasons users alter their behaviors and perceptions of spatiality and sociality while engaging with location-based social networks (LBSN). Despite the potential for this interplay to further our understanding of LBSN usage in the context of identity, very little work has actually been done towards this. Addressing this gap in the literature is one the chief aims of the article. Drawing on an original six-week study with 42 participants utilizing a bespoke LBSN entitled ‘GeoMoments’, our research explores: (1) the way that territoriality is linked to self-identity; and (2) how …

Acts Of Meaning, Resource Diagrams, And Essential Learning Behaviors: The Design Evolution Of Lost & Found, Owen Gottlieb, Ian Schreiber

Articles

Lost & Found is a tabletop-to-mobile game series designed for teaching medieval religious legal systems. The long-term goals of the project are to change the discourse around religious laws, such as foregrounding the prosocial aspects of religious law such as collaboration, cooperation, and communal sustainability. This design case focuses on the evolution of the design of the mechanics and core systems in the first two tabletop games in the series, informed by over three and a half years’ worth of design notes, playable prototypes, outside design consultations, internal design reviews, playtests, and interviews.

N-Cyclo­Pentyl-N-(3-Oxo-2,3-Dihydro-1h-Inden-1-Yl)Acetamide, Tao Zhang, Tom Mccabe, Bartosz Marzec, Neil Frankish, Helen Sheridan

Articles

The title mol­ecule, C₁₆H₁₉NO₂, consists of an indane moiety, which is connected through an N atom to an acetamide group and a cyclo­pentane ring. The N atom adopts planar triangular geometry. Inter­molecular inter­actions, such as π–π stacking or hydrogen bonding, were not observed.

2-(Di­Phenyl­Methyl­Idene)-2,3-Di­Hydro-1h-Inden-1-One, Tao Zhang, Vilmar Bandero, Tom Mccabe, Neil Frankish, Helen Sheridan

Articles

In the title mol­ecule, C₂₂H₁₆O, the indanone ring system is approximately planar with a dihedral angle between the fused rings of 5.13 (14)°. Two benzene rings are linked together at one side of a double bond, sitting on either side of the indanone ring system and making dihedral angles of 70.30 (12) and 44.74 (13)° with it. In the crystal, hydrogen bonding is not present, but weak C—H⋯π or π–π inter­actions occur and mol­ecules form a sheet-like structure in the bc plane.

Antidiabetic Activities Of An Lc/Ms Fingerprinted Aqueous Extract Of Fagonia Cretica L. In Preclinical Models, Imran Nazir, Nisar Ur Rahman, Zunaira Alvi, M. Hafizur Rahman, Jandirk Jandirk Sendker, Tao Zhang, Neil Frankish, Helen Sheridan

Articles

Diabetes mellitus is a chronic disease and one of the most important public health challenges facing mankind. Fagonia cretica is a medicinal plant used widely in the Punjab in Pakistan. A recent survey has demonstrated that traditional healers and herbalists frequently use this plant to treat diabetes. In the current study, the traditional medicine was prepared as a tea, and the profile of the main metabolites present in the traditional medicine was analysed via LC/MS/MS. The extract was shown to contain a number of phenolic glycosides including quercetin-3-O-rutinoside, kaempferol-3-O-rutinoside, kaempferol-3-O-glycoside, kaempferol-3(6′-malonylglucoside), isorhamnetin-3-O-rutinoside, and isorhamnetin 3-(6″-malonylglucoside) in addition to two unidentified …

Characterization Of Antimicrobial Effects Of Plasma-Treated Water (Ptw) Produced By Microwave-Induced Plasma (Midiplexc) On Pseudomonas Fluorescens Biofilms, Oliver Handorf, Viktoria Isabella Pauker, Thomas Weihe, Eric Freund, Sander Bekeschus, Katharina Riedel, Uta Schnabel, Jörg Ehlbeck

Articles

stract: For the decontamination of surfaces in the food production industry, plasma generated compounds (PGCs) such as plasma-treated water (PTW) or plasma processed air (PPA) offer many promising possibilities for future applications. Therefore, the antimicrobial effect of water treated with microwave-induced plasma (MidiPLexc) on Pseudomonas fluorescensbiofilms was investigated. 10 ml deionized water was treated with the MidiPLexc plasma source for 100 s, 300 s and 900 s (pre-treatment time) and the bacterial biofilms were exposed to the PTW for 1 min, 3 min and 5 min (post treatment time). To investigate the influence of PTW on P. fluorescensbiofilms, microbiological assays …

In Situ Image Processing And Data Binning Strategy For Particle Engineering Applications, Toufic El Arnaout, Patrick J. Cullen

Articles

Crystallization control can be improved through real-time monitoring technologies. Here, a workflow is demonstrated on rapid batch cooling crystallization of L-glutamic acid. First, in situ images were generated using video microscopy sensors and analyzed, by employing a single, rapid macro code to extract particle data descriptors. A binning procedure (over time) was performed, where every data point represented the counts of particles within a specific size or shape range per 100 images. This binning method was found more informative in tracking of the populations compared to whole image averages or individual particle datapoints. This study provides a step-by-step guide towards …

Adaptive Background Correction Of Crystal Image Datasets: Towards Automated Process Control, Luke Kiernan, Ian Jones, Lauri Kurki, Patrick J. Cullen, Toufic El Arnaout

Articles

Improving the data descriptor calculation of crystal’s physical properties requires sophisticated imaging techniques and algorithms. It has been possible to construct 2D population balance models benefiting from characteristic measurements of both crystal’s length and width, compared to the single representative sizes used in 1D models. Our aim is to ameliorate the procedure of determining shape (and not only size) factors, in an automated fashion and directly from the process, for implementation in future models. Here, approaches suitable for real-time applications were employed including engineered imaging sensors and adaptive algorithms. We described the latter in detail for varying 2D image datasets. …