Digital Commons Network^™

Adaptive Background Correction Of Crystal Image Datasets: Towards Automated Process Control, Luke Kiernan, Ian Jones, Lauri Kurki, Patrick J. Cullen, Toufic El Arnaout

Articles

Improving the data descriptor calculation of crystal’s physical properties requires sophisticated imaging techniques and algorithms. It has been possible to construct 2D population balance models benefiting from characteristic measurements of both crystal’s length and width, compared to the single representative sizes used in 1D models. Our aim is to ameliorate the procedure of determining shape (and not only size) factors, in an automated fashion and directly from the process, for implementation in future models. Here, approaches suitable for real-time applications were employed including engineered imaging sensors and adaptive algorithms. We described the latter in detail for varying 2D image datasets. …

Quantitative Analysis Of Human Blood Serum Using Vibrational Spectroscopy., Hugh Byrne, Franck Bonnier, Jennifer Mcintyre, Drishya Rajan Parachalil

Articles

Analysis of bodily fluids using vibrational spectroscopy has attracted increasing attention in recent years. In particular, infrared spectroscopic screening of blood products, particularly blood serum, for disease diagnostics has been advanced considerably, attracting commercial interests. However, analyses requiring quantification of endogenous constituents or exogenous agents in blood are less well advanced. Recent advances towards this end are reviewed, focussing on infrared and Raman spectroscopic analyses of human blood serum. The importance of spectroscopic analysis in the native aqueous environment is highlighted, and the relative merits of infrared absorption versus Raman spectroscopy are considered, in this context. It is argued that …

(Re)Visions Of The Outre-Mer: Looking At The Male Gaze In Jacques Feyder’S Le Grand Jeu (1934), Barry Nevin

Articles

Cinéma colonial is regarded by certain scholars as a highly conventionalised and commercialised film practice that grants spectators a sense of control over the potentially threatening colonial Other, and Belgian director Jacques Feyder has been subject to particularly harsh criticism in this regard. This article argues that Feyder’s Le Grand Jeu (1934), which depicts a young legionnaire’s relationship with a cabaret singer who bears an uncanny resemblance to a previous lover who jilted him in Paris, challenges dominant tendencies in portrayals of gender and colonialism in French cinema of the 1930s. Drawing on the relationship between Laura Mulvey’s theorisation of …

Calibration To Mitigate Near-Field Antennas Effects For A Mimo Radar Imaging System, Ha Hoang, Matthias John, Patrick Mcevoy, Max Ammann

Articles

A calibration method for a high-resolution hybrid MIMO turntable radar imaging system is presented. A line of small metal spheres is employed as a test pattern in the calibration process to measure the position shift caused by undesired antenna effects. The unwanted effects in the antenna near-field responses are analysed, modelled and significantly mitigated based on the symmetry and differences in the responses of the MIMO configuration.

In-Vitro Localisation And Degradation Of Few-Layer Mos2 Submicrometric Plates In Human Macrophage-Like Cells: A Label Free Raman Micro-Spectroscopic Study, Caroline Moore, Andrew Hrvey, Jonathan N. Coleman, Hugh Byrne, Jennifer Mcintyre

Articles

Monitoring the uptake, micro-environment and fate of micro or nano scaled particulate materials in cells is of paramount importance for the emerging fields of toxicology and medicine. Such particulate materials are known to interfere with colorimetric assays and many such assays record only a single end-point. Therefore, there is a need for a label-free, cost effective technique with little or no inference from the particulate materials. Raman micro-spectroscopy was used to simultaneously interrogate the integrity of few-layer MoS2 submicrometric plates in human macrophage-like cells, in-vitro, as well as the biochemical characteristics of the local micro-environment in which they are encompassed. …

Raman Mapping Coupled To Self Modelling Mcr-Als Analysis To Estimate Active Cosmetic Ingredient Penetration Profile In Skin, Aline Stella, Franck Bonnier, Ali Tfayli, Florent Yvergnaux, Hugh Byrne, Igor Chourpa, Emilie Munnier, Clovis Tauber

Articles

Confocal Raman mapping (CRM) is a powerful, label free, non-destructive tool, enabling molecular characterization of human skin with applications in the dermo-cosmetic field. Coupling CRM to multivariate analysis can be used to monitor the penetration and permeation of active cosmetic ingredients (ACI) after topical application. It is presently illustrated how multivariate curve resolution alternating least squares (MCR-ALS) can be applied to detect and semi-quantitatively describe the diffusion profile of Delipidol, a commercially available slimming ACI, from Raman spectral maps. Although the analysis outcome can be critically dependent on the a priori selection of the number of regression components, it is …

A “Net-Centric” Conduct Of Navigation And Ship Management, Dimitrios Dalaklis, Georgios Katsoulis, Momoko Kitada, Jens-Uwe Schröder-Hinrichs, Aykut I. Ölcer

Articles

Following the so-called “Industrial Revolution”, the shipping industry has benefitted from a very extended number of technology innovations. Over time, shipbuilding practices and the equipment of ships have been significantly improved. Furthermore,

during the last couple of decades, the continuous improvement and integration- interconnection of electronics systems (the “network-centric” approach), have created

a new operating environment for shipping. It is therefore not a coincidence that recent discussions on digitalization and autonomous ships provide a disruptive picture of how this industry may be transformed in the near future. Contemporary sea-going vessels are equipped with various technologically advanced systems and are highly …

Consumer Activism: From The Informed Minority To The Crusading Minority, Yonathan A. Arbel, Roy Shapira

Articles

Legal scholars have long recognized that market norms are respected not only because of consumer protection laws, but also because of internal market dynamics. Consumers, the argument goes, fend for themselves and hold sellers accountable. But how exactly do consumers discipline sellers? The most influential model has been the informed minority theory, according to which a critical mass of informed consumers reads and negotiates contracts in advance, thereby pressuring sellers to offer better contracts to all consumers. Recent empirical studies, however, cast doubt on the existence of such a mass, leading many to view the informed minority theory as unrealistic. …

Accounting For The Local Field When Determining The Dielectric Loss Spectra Of Metals In The Region Of The Frequencies Of Volume, Surface And Localized Plasmon Oscillations, Tatiana Perova, Igor Shaganove, Kevin Berwick

Articles

The optical constant of bulk metal is used to determine the dispersion of the local field under one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) confinement. 3D confinement, expressed as ε mic 2 (ω3D), corresponds to the dielectric loss spectra of spherical particles with a diameter, d, much less than the wavelength of the beam used to measure the spectrum (d << λ). Excellent agreement with the results of Mie theory and experimental data for solid colloids within alkali halide crystals was observed. The function expressed as ε mic 2 (ω1D) allows the measurement of spectral micro-characteristics in the frequency range of the longitudinal collective motion of the free electrons. This corresponds to the spectrum of dielectric losses of bulk plasma oscillations. The function ε mic 2 (ω2D) describes the spectra of the dielectric losses of surface plasma oscillations in thin metal films. It is shown that the peak positions of ε mic 2 (ω3D), ε mic 2 (ω2D) and ε mic 2 (ω1D) spectra for simple metals, viz. alkali metals as well as Al, Be, Mg, Ga, In, Sn and Si, are in agreement with experimental results from electron-energy-loss spectroscopy and various optical techniques.

The Effect Of High Background And Dead Time Of An Ingaas/Inp Single-Photon Avalanche Photodiode On The Registration Of Microsecond Range Near-Infrared Luminescence, P. S. Parfenov, A. P. Litvin, D. A. Onishchuk, K. A. Gonchar, Kevin Berwick, A. V. Fedorov, A. V. Baranov

Articles

The effects of a high background count and a microsecond dead time interval on a gated InGaAs/InP single-photon avalanche photodiode (SPAD) during microsecond luminescence decay registration are discussed. It is shown that the background count rate of the SPAD limits its use for time-resolved and steady-spectral measurements, and that a “pile-up” effect appears in the microsecond range.

Microrna Analysis Of Atm-Deficient Cells Indicate Pten And Ccdn1 As Potential Biomarkers Of Radiation Response, Jane Bryant, Lisa White, Natasha Coen, Laura Shields, Brendan Mcclean, Aidan Meade, Fiona Lyng, Orla L. Howe

Articles

Genetic and epigenetic profile changes associated with individual radiation sensitivity are well documented and have led to enhanced understanding of the mechanisms of the radiation-induced DNA damage response. However, the search continues to identify reliable biomarkers of individual radiation sensitivity. Herein, we report on a multi-biomarker approach using traditional cytogenetic biomarkers, DNA damage biomarkers and transcriptional microRNA (miR) biomarkers coupled with their potential gene targets to identify radiosensitivity in ataxia-telangiectasia mutated (ATM)-deficient lymphoblastoid cell lines (LCL); ATM-proficient cell lines were used as controls. Cells were 0.05 and 0.5 Gy irradiated, using a linear accelerator, with sham-irradiated cells as controls. At …

Associations Between The Home Environment, Feeding Practices And Children’S Intakes Of Fruit, Vegetables And Confectionary/Sugar-Sweetened Beverages, Carolina Bassu, Clare Corish, John Kearney

Articles

Within the home environment, parents influence their children’s dietary intakes through their parenting and dietary practices, and the foods they make available/accessible. The aim of this cross-sectional study was to examine the associations between home environmental characteristics and children’s dietary intakes. Three hundred and thirty-two children aged three–five years and their parents participated in the study. Home environmental characteristics, including parental control feeding practices, were explored using validated and standardized questionnaires such as the Child Feeding Questionnaire (CFQ), the Physical and Nutritional Home Environment Inventory (PNHEI) and the Healthy Home Survey (HHS). Parent and child food consumption was also measured. …

Introducing A Model And A Framework To Unify The Pharmaceutical Quality System Enablers Quality Risk Management & Knowledge Management, Martin J. Lipa, Kevin O'Donnell, Anne Greene

Articles

An organization that effectively manages knowledge should be able to recognize and proactively apply new learnings to better anticipate risks. This is particularly important in the manufacture of medicinal products. Since the publication of ICH Q10 in 2010, Quality Risk Management (QRM) and Knowledge Management (KM) have been positioned as co-enablers to the Pharmaceutical Quality System. The authors of this paper present a Knowledge Management process model to foster greater practical understanding of the practice of knowledge management. This model when joined with the familiar ICH Q9 process model for QRM, should enable a company to better manage their knowledge …

Tracing Sources Of Natural Organic Matter, Trihalomethanes And Metals In Groundwater From A Karst Region, Connie O'Driscoll, Eoin Mcgillicuddy, Peter Croot, Pamela Bartley, John Mcmyler, Jerome Sheahan, Liam Morrison

Articles

Groundwater offers an important source for drinking water around the world; however, groundwater quality is under increasing pressure and is particularly vulnerable in karst areas. Total organic carbon (TOC) is significantly related to groundwater quality and when not removed by water treatment processes can give rise to the formation of disinfection by-products trihalomethanes (THMs) above the level of compliance. This study investigated the source of organic matter giving rise to the THM exceedances in a groundwater supply in a karst area. Results highlighted that source water for this groundwater supply was prone to surface water infiltration linked to rainfall events; …

Performance Investigation Of Peak Shrinking And Interpolating The Papr Reduction Technique For Lte-Advance And 5g Signals, Somayeh Mohammady, Ronan Farrell, David Malone, John Dooley

Articles

Orthogonal frequency division multiplexing (OFDM) has become an indispensable part of waveform generation in wideband digital communication since its first appearance in digital audio broadcasting (DAB) in Europe in 1980s, and it is indeed in use. As has been seen, the OFDM based waveforms work well with time division duplex operation in new radio (NR) systems in 5G systems, supporting delay-sensitive applications, high spectral efficiency, massive multiple input multiple output (MIMO) compatibility, and ever-larger bandwidth signals, which has demonstrated successful commercial implementation for 5G downlinks and uplinks up to 256-QAM modulation schemes. However, the OFDM waveforms suffer from high peak …

Cognitive Performance In Midlife Type 2 Diabetes: Results Form The Enbind Study, A. H. Dyer, L. Mckenna, G. Gamage, N. M. Bourke, Isabelle Killane, M. Widdowson, C. P. Woods, J. Gibney, R. Reilly, D. O'Neill, S. P. Kennelly

Articles

Aims: To establish the impact of uncomplicated type 2 diabetes on cognitive and neuropsychological performance in midlife. Methods: We performed a cross-sectional study of middle-aged adults with uncomplicated type 2 diabetes and a cohort of healthy control participants. General cognition was assessed using the Montreal Cognitive Assessment test and neuropsychological assessment was undertaken using a detailed neuropsychological assessment battery. Results: A total of 152 participants (102 with type 2 diabetes and 50 controls) were recruited (mean age 52 ± 8 years, 51% women). Participants with midlife type 2 diabetes were more than twice as likely to make an error on …

Reformulating The Binary Masking Approach Of Adress As Soft Masking, Ruairí De Fréin

Articles

Binary masking forms the basis for a number of source separation approaches that havebeen successfully applied to the problem of de-mixing music sources from a stereo recording.A well-known problem with binary masking is that, when music sources overlap in the time-frequencydomain, only one of the overlapping sources can be assigned the energy in a particulartime-frequency bin. To overcome this problem, we reformulate the classical pan-pot source separationproblem for music sources as a non-negative quadratic program. This reformulation gives rise toan algorithm, called Redress, which extends the popular Adress algorithm. It works by definingan azimuth trajectory for each source based on …

Impact Assessment Of High-Power Domestic Ev Charging Proliferation Of A Distribution Network, Arsalan Zaidi, Keith Sunderland, Michael Conlon

Articles

Transport electrification is becoming the mainstream as a means to improve efficiency, performance, andsustainability of transportation systems. Electrical vehicles (EVs) can help to de-carbonise the environment, but a downside isthe technical issues presented to the low-voltage distribution network. To quantify the stochastic nature of transport-affectedelectrification, probabilistic load flow is employed. Monte Carlo-based simulation is applied to accommodate the probabilisticuncertainties associated with variable EV charging patterns. This study considers high-power charging (up to 11 kW) at thedomestic level while monitoring power quality variations (voltage drop, voltage unbalance factor, voltage sag) standards. Thiswork focuses on the Irish and UK, distribution system operator's–transmission …

A Conceptual Model To Explain Dark Matter And Dark Energy, Jonathan Blackledge

Articles

t This paper considers a conceptual model that attempts to explain ‘Dark Matter’ and ‘Dark Energy’. The model is based on considering a gravitational field to be the result of a mass (a Higgs field) scattering pre-existing cosmic background space-time waves or ‘Uber-waves’. The term ‘Uber’ is used to denote an outstanding or supreme example of a particular kind of gravitational wave with cosmic-scale wavelengths that are far in excess of those associated with the gravitational waves generated by accelerating masses. Such waves are taken to be the very lowest frequency components associated with the spectrum of space-time waves generated …

Indirect Sliding Mode Control For Dc-Dc Sepic Converters, Hasan Komurcugil, Samet Biricik, Naki Guler

Articles

This article presents an indirect sliding mode control (SMC) for single-ended primary-inductor converters (SEPIC). Unlike the conventional SMC methods, the proposed SMC method employs a sliding surface function based on the input current error only. The use of such sliding surface function not only simplifies the implementation but also reduces the cost of implementation. It is shown that the output voltage control can be achieved indirectly. The input current reference is generated by a proportional-integral (PI) regulator. The existence condition and the region of the closed-loop system are determined for all possibilities of the PI gains. The performance of the …

A Novel Pool Of Microparticle Cholesterol Is Elevatedin Rheumatoid Arthritis But Not In Systemic Lupus Erythematosus Patients, Shuai Shuai Hu, Brenton L. Cavanagh, Robert Harrington, Muddassar Ahmad, Grainne Kearns, Steve Meaney, Claire Wynne

Articles

Microparticles are sub-micron, membrane-bound particles released from virtually allcells and which are present in the circulation. In several autoimmune disorders their amountand composition in the circulation is altered. Microparticle surface protein expression has beenexplored as a differentiating tool in autoimmune disorders where the clinical pictures can overlap.Here, we examine the utility of a novel lipid-based marker—microparticle cholesterol, present in allmicroparticles regardless of cellular origin—to distinguish between rheumatoid arthritis (RA) andsystemic lupus erythematosus (SLE). We first isolated a series of microparticle containing lipoproteindeficient fractions from patient and control plasma. There were no significant differences in thesize, structure or protein content of …

Diclofenac Determination Using Ceo2 Nanoparticle Modified Screen-Printed Electrodes:A Study Of Background Correction, Rafaela C. De Carvalho, Tony Betts, John Cassidy

Articles

The detection of low levels of drugs including Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in natural waters and wastewaters is becoming increasingly important. Electrochemical methods offer an attractive means of detection, as they overcome many disadvantages associated with the currently available analytical methods. Cerium dioxide nanoparticles were synthesised and then incorporated onto the working electrodes of commercial graphite-based Screen Printed Carbon Electrodes (SPCE) then used to determine diclofenac levels. Following initial Cyclic Voltammetry studies, Square Wave Voltammetry (SWV) investigations were conducted over a range of conditions to optimise the peak potential separation and sensitivity of the method. The use of background correction …

Polyvinyl Alcohol Cryogel Based Vessel Mimicking Material For Modelling The Progression Of Atherosclerosis, Andrew Malone, Sean Cournane, Izabela Naydenova, Andrew J. Fagan, Jacinta Browne

Articles

Purpose

The stiffness of Polyvinyl-alcohol cryogel can be adjusted through application of consecutive freeze-thaw cycles. This material has potential applications in the production of tissue mimicking phantoms in diagnostic ultrasound. The aim of this study was to use PVA-c to produce a range of geometrically and acoustically identical vessel phantoms modelling stages of atherosclerosis which could be verified through mechanical testing, thus allowing for more precision in quantitative in-vitro flow analysis of atherosclerosis.

Methods

A series of anatomically realistic walled renal artery flow phantoms were constructed using PVA-c. In order to ensure precise modelling of atherosclerosis, a modified procedure of …

Flash Vep In Clinically Stable Pre-Term And Full-Term Infants, Anish Kharal, Safal Khanal, Jyoti Baba Shrestha, Gauri Shankar Shrestha, Nabin Paudel

Articles

Purpose

Pre-term infants are at risk of abnormal visual development that can range from subtle to severe. The aim of this study was to compare flash VEPs in clinically stable pre-term and full-term infants at 6 months of age.

Methods

Twenty-five pre-term and 25 full-term infants underwent flash VEP testing at the age of 6 months. Monocular VEPs were recorded using flash goggles on a RETIscan system under normal sleeping conditions. Amplitude and peak time responses of the P2 component in the two eyes were averaged and compared between the two groups. Multiple regression analyses were performed to assess the …

Smartphone Use As A Possible Risk Factor For Myopia, Saoirse Mccrann, James Loughman, John Butler, Nabin Paudel, Daniel Ian Flitcroft

Articles

Clinical Relevance

This study demonstrates an association between myopia and smartphone data usage. Youths now spend more time participating in near tasks as a result of smartphone usage. This poses an additional risk factor for myopia development/progression and is an important research question in relation to potential myopia management strategies.

Background

Children are now exposed to another possible environmental risk factor for myopia-smartphones. This study investigates the amount of time students spend on their smartphones and their pattern of smartphone usage from a myopia perspective.

Methods

Primary, secondary and third-level students completed a questionnaire exploring patterns of smartphone usage and …

Towards A Rapid Screening Of Liver Grafts At The Operating Room Using Mid-Infrared Spectroscopy, David Perezguaita, Marta Moreno Torres, Ramiro Jover, Eugenia Pareja, Bernard Lendl, Julia Kuligowsky, Guillermo Quintas

Articles

The estimation of steatosis in a liver graft is mandatory prior to liver transplantation, as the risk of graft failure increases with the level of infiltrated fat. However, the assessment of liver steatosis before transplantation is typically based on a qualitative or semiquantitative characterization by visual inspection and palpation and histological analysis. Thus, there is an unmet need for transplantation surgeons to have access to a diagnostic tool enabling an in situ fast classification of grafts prior to extraction. In this study, we have assessed an attenuated total reflection−Fourier transform infrared (ATR−FTIR) spectroscopic method compatible with the requirements of an …

A Vibrational Spectroscopic Based Approach For Diagnosing Babesia Bovis Infection, Anja Ruther, David Perezguaita, William Poole, Brian Cooke, Carlos Suarez, Philip Heraud, Bayden Wood

Articles

Babesia bovis parasites present a serious and significant health concern for the beef and dairy industries in many parts of the world. Difficulties associated with the current diagnostic techniques include they are prone to human error (microscopy) or expensive and time consuming (Polymerase Chain Reaction) to perform. Little is known about the biochemical changes in blood that are associated with Babesia infections. The discovery of new biomarkers will lead to improved diagnostic outcomes for the cattle industry. Vibrational spectroscopic technologies can record a chemical snapshot of the entire organism and the surrounding cell thereby providing a phenotype of the organism …

Empirical Study On The Effects Of Acquisition Parameters For Ftir Hyperspectral Imaging Of Brain Tissue, David Perezguaita, Julia Sacharz, Mustafa Kasniz, Shaiju Nazeer, Bayden Wood, Philip Heraud

Articles

Fourier transform infrared (FTIR) spectroscopic imaging is a powerful technique for molecular imaging of pathologies associated with the nervous systems including multiple sclerosis research. However, there is no standard methodology or standardized protocol for FTIR imaging of tissue sections that maximize the ability to discriminate between the molecular, white and granular layers, which is essential in the investigation of the mechanism of demyelination process. Tissue sections are heterogeneous, complex and delicate, hence the parameters to generate high quality images in minimal time becomes essential in the modern clinical laboratory. This article presents an FTIR spectroscopic imaging study of post-mortem human …

In-Situ Ellipsometric Study Of The Optical Properties Of Ltl-Doped Thin Film Sensors For Copper(Ii) Ion Detection, Dervil Cody, Tsvetanka Babeva, Violeta Madjarova, Anastasia Kharchenko, Sabad-E- Gul, Svetlana Mintova, Christopher J. Barrett, Izabela Naydenova

Articles

Optical sensors fabricated in zeolite nanoparticle composite films rely on changes in their optical properties (refractive index, n, and thickness, d) to produce a measurable response in the presence of a target analyte. Here, ellipsometry is used to characterize the changes in optical properties of Linde Type L (LTL) zeolite thin films in the presence of Cu2+ ions in solution, with a
/="/">view to improving the design of optical sensors that involve the change of n and/or d due to the adsorption of Cu2+ ions. The suitability of two different ellipsometry techniques (single wavelength and spectroscopic) for the evaluation …

Prevalence Of Colour Vision Deficiency In The Republic Of Ireland Schoolchildren And Associated Socio-Demographic Factors, Síofra Harrington, Peter Davison, Veronica O'Dwyer

Articles

Clinical relevance: Early screening is essential to counsel schoolchildren with congenital colour vision deficiency (CVD) in determining their future career path and to advise teachers of the impact of CVD on classroom difficulties.

Background: Congenital CVD is an X-linked genetic abnormality relatively commonplace in humans. This study aimed to determine the prevalence of congenital CVD in the Republic of Ireland schoolchildren and associated socio-demographic factors.

Methods: A total of 1,626 schoolchildren (882 boys and 744 girls), in two age groups (728 aged 6–7 years and 898 aged 12–13 years) were examined from randomly selected schools. Colour vision …