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Articles 991 - 1020 of 2753
Full-Text Articles in Entire DC Network
The Second Circuit And Social Justice, Matthew Diller, Alexander A. Reinert
The Second Circuit And Social Justice, Matthew Diller, Alexander A. Reinert
Articles
The Second Circuit is renowned for its landmark rulings in fields such as white collar crime and securities law — bread and butter issues growing out of Wall Street’s preeminence in the financial landscape of the nation. At the same time, the Second Circuit has a long tradition of breaking new ground on issues of social justice. Unlike some circuit courts which have reputations in the area of social justice built around one or two fields, such as the Fifth Circuit’s pioneering role in civil rights litigation or the Ninth Circuit’s focus on immigration, there is no one area of …
Faith And Unbelief : Brian Moore's Priestly Depictions, Eamon Maher
Faith And Unbelief : Brian Moore's Priestly Depictions, Eamon Maher
Articles
No abstract provided.
Information-Dissemination Law: The Regulation Of How Market-Moving Information Is Revealed, M. Todd Henderson, Kevin S. Haeberle
Information-Dissemination Law: The Regulation Of How Market-Moving Information Is Revealed, M. Todd Henderson, Kevin S. Haeberle
Articles
No abstract provided.
Gold Nanostars For Efficient In Vitro And In Vivo Real-Time Sers Detection And Drug Delivery Via Plasmonic-Tunable Raman/Ftir Imaging, Furong Tian, Joao Conde, Chenchen Bao, Yunsheng Chen, James Curtin, Daxiang Cui
Gold Nanostars For Efficient In Vitro And In Vivo Real-Time Sers Detection And Drug Delivery Via Plasmonic-Tunable Raman/Ftir Imaging, Furong Tian, Joao Conde, Chenchen Bao, Yunsheng Chen, James Curtin, Daxiang Cui
Articles
The application of plasmonic-enhanced Raman imaging of cancer cells and drug delivery is gaining momentum. Here, we propose a new theranostic strategy based on an efficient plasmonic-tunable Raman/Fourier transform infrared (FTIR) spectroscopy imaging, to simultaneously evaluate the anticancer drug scattering cellular imaging and the Raman scattering molecular vibration signals in living cells. This technique allows to monitoring the drug release throughout the cell cycle and in vivo biodistribution and biocompatibility with low dose drug therapy (200 µg/mL) and low toxicity effect. This system can directly track in real-time the delivery and release of an anticancer drug (mitoxantrone, MTX) from gold …
Quizmastery: Students As Bloggers And Testers In Pursuit Of Grammatical Competence, Sue Norton, Odette Gabaudan
Quizmastery: Students As Bloggers And Testers In Pursuit Of Grammatical Competence, Sue Norton, Odette Gabaudan
Articles
This article considers the challenges confronted by instructors of composition and writing skills in higher education. Identifying key aspects of grammar, syntax, and punctuation, it argues that a grammatically informed terminology is helpful to learner-writers endeavouring to improve the clarity of their written assignments. To aid assimilation of this terminology, and the concepts it signifies, e-learning tools can be integrated into the curriculum so that students can consolidate knowledge through their own construction of it. As they create blogs and peer to peer quizzes, they become more theoretically and practically informed about the basis of effective writing practices.
Proceedings 26th Polar Libraries Colloquy Mapping Change: Chitduug Gha Nen' Ch'etnetl'edz, Daria O. Carle, Marvin Falk, Bev Ager, Stéfano Biondo, Joë Bouchard, Marcel Brannemann, Sandy Campbell, Andrew Gray, Gloria Hicks, Laura J. Kissel, Ulyana Koratkova, Peter Lund, Shannon C. Vossepoel, Ali Shiri, Dinesh Rathi, Cathy Cockney, Sharon Farnel, Elaine Maloney, Robyn Stobbs, Susanna Parikka, Shelly Sommer, Sharon Tahirkheli, Maribeth S. Murray, Steve Liang, James P. Badger, Bindu Panikkar, Byron Chu, Sandy Campell, Heidi Mccann
Proceedings 26th Polar Libraries Colloquy Mapping Change: Chitduug Gha Nen' Ch'etnetl'edz, Daria O. Carle, Marvin Falk, Bev Ager, Stéfano Biondo, Joë Bouchard, Marcel Brannemann, Sandy Campbell, Andrew Gray, Gloria Hicks, Laura J. Kissel, Ulyana Koratkova, Peter Lund, Shannon C. Vossepoel, Ali Shiri, Dinesh Rathi, Cathy Cockney, Sharon Farnel, Elaine Maloney, Robyn Stobbs, Susanna Parikka, Shelly Sommer, Sharon Tahirkheli, Maribeth S. Murray, Steve Liang, James P. Badger, Bindu Panikkar, Byron Chu, Sandy Campell, Heidi Mccann
Articles
Published July 2023 by the University of Alaska Anchorage, UAA/APU Consortium Library, and edited by Daria O. Carle. Copyright in individual papers is held by the contributors. A digital copy of this publication can be found at https://polarlibraries.org/colloquy-proceedings/ and in ScholarWorks, the University of Alaska’s Institutional Repository, https://scholarworks.alaska.edu/. A copy of the 2016 Colloquy program is also available at https://polarlibraries.org/colloquy-proceedings/. Further information on the Polar Libraries Colloquy, including details of membership and upcoming conferences, is available at https://polarlibraries.org
Spectroscopic Studies Of Anthracyclines: Structural Characterization And In Vitro Tracking, Zeineb Farhane, Hugh Byrne, Malgorzata Baranska
Spectroscopic Studies Of Anthracyclines: Structural Characterization And In Vitro Tracking, Zeineb Farhane, Hugh Byrne, Malgorzata Baranska
Articles
A broad spectroscopic characterization, using ultraviolet-visible (UV-vis) and Fourier transform infrared absorption as well as Raman scattering, of two commonly used anthracyclines antibiotics (DOX) daunorubicin (DNR), their epimers (EDOX, EDNR) and ten selected analogs is presented. The paper serves as a comprehensive spectral library of UV-vis, IR and Raman spectra of anthracyclines in the solid state and in solution. The particular advantage of Raman spectroscopy for the measurement and analysis of individual antibiotics is demonstrated. Raman spectroscopy can be used to monitor the in vitro uptake and distribution of the drug in cells, using both 488 nm and 785 nm …
Linking Social Capital, Cultural Capital And Heterotopia At The Folk Festival, Linda Wilks, Bernadette Quinn
Linking Social Capital, Cultural Capital And Heterotopia At The Folk Festival, Linda Wilks, Bernadette Quinn
Articles
This paper investigates the role of folk festivals in transforming interconnections between people, space and culture. It interlinks three sets of theoretical ideas: social capital, cultural capital and heterotopia to suggest a new conceptual framework that will help to frame a deeper understanding of the nature of celebration. Qualitative data were collected at two long-established folk festivals, Sidmouth Folk Festival in southern England and the Feakle Traditional Music Festival in western Ireland, in order to investigate these potential links. Although Foucault did not fully develop the concept of heterotopia, his explanation that heterotopias are counter-sites, which, unlike utopias, are located …
The Role Of Guidances In Modern Administrative Procedure: The Case For De Novo Review, Richard A. Epstein
The Role Of Guidances In Modern Administrative Procedure: The Case For De Novo Review, Richard A. Epstein
Articles
No abstract provided.
Linguistic Relativism And The Decline Of The Rule Of Law, Richard A. Epstein
Linguistic Relativism And The Decline Of The Rule Of Law, Richard A. Epstein
Articles
No abstract provided.
What Bankruptcy Law Can And Cannot Do For Puerto Rico, John A. E. Pottow
What Bankruptcy Law Can And Cannot Do For Puerto Rico, John A. E. Pottow
Articles
This article is based on a February 2016 keynote address given at the University of Puerto Rico Law Review Symposium “Public Debt and the Future of Puerto Rico.” Thus, much of it remains written in the first person, and so the reader may imagine the joy of being in the audience. (Citations and footnotes have been inserted before publication ‒ sidebars that no reasonable person would ever have inflicted upon a live audience, even one interested in bankruptcy law. Rhetorical accuracy thus yields to scholarly pedantics.) The analysis explains how bankruptcy law not only can but will be required to …
The Scrivener's Error, Ryan D. Doerfler
Using Terahertz Time-Domain Spectroscopy To Discriminate Among Water Contamination Levels In Diesel Engine Oil, Ali M. Abdul-Munaim, Marco Reuter, Oday M. Abdulmunem, Jan C. Balzer, Martin Koch, Dennis G. Watson
Using Terahertz Time-Domain Spectroscopy To Discriminate Among Water Contamination Levels In Diesel Engine Oil, Ali M. Abdul-Munaim, Marco Reuter, Oday M. Abdulmunem, Jan C. Balzer, Martin Koch, Dennis G. Watson
Articles
Terahertz time-domain spectroscopy (THz-TDS) in the range of 0.5 to 2.0 THz was evaluated for discriminating among water contamination levels (0%, 0.1%, and 0.2%) in diesel engine oil (SAE 15W-40). The absorption coefficient demonstrated potential to discriminate among the three water contamination levels with significant differences among all three levels across the 1.111 to 1.332 THz and 1.669 to 1.934 THz ranges. At each of these frequency ranges, each water contamination level was significantly different from the other two. The 0% water contamination level had the lowest absorption coefficient, while 0.2% water had the highest absorption coefficient. The refractive index …
A Comparison Of Catabolic Pathways Induced In Primary Macrophages By Pristine Single Walled Carbon Nanotubes And Pristine Graphene, Caroline More, Jennifer Mcintyre, Luke O'Neill, Hugh Byrne
A Comparison Of Catabolic Pathways Induced In Primary Macrophages By Pristine Single Walled Carbon Nanotubes And Pristine Graphene, Caroline More, Jennifer Mcintyre, Luke O'Neill, Hugh Byrne
Articles
Understanding the correlation between the physico-chemical properties of carbonaceous nanomaterials and how these properties impact on cells and subcelluar mechanisms is critical to their risk assessment and safe translation into newly engineered devices. Here the toxicity, uptake and catabolic response of primary human macrophages to pristine graphene (PG) and pristine single walled carbon nanotubes (pSWCNT) are explored, compared and contrasted. The nanomaterial toxicity was assessed using three complementary techniques (live-dead assay, real time impedance technique and confocal microscopic analysis), all of which indicated no signs of acute cytotoxicity in response to PG or pSWCNT. Transmission electron microscopy (TEM) demonstrated that …
Sage Grouse Groceries: Forb Response To Piñon-Juniper Treatments, Jonathan D. Bates, Kirk W. Davies, April Hulet, Richard F. Miller, Bruce Roundy
Sage Grouse Groceries: Forb Response To Piñon-Juniper Treatments, Jonathan D. Bates, Kirk W. Davies, April Hulet, Richard F. Miller, Bruce Roundy
Articles
Juniper and piñon coniferous woodlands have increased 2- to 10-fold in nine ecoregions spanning the Intermountain Region of the western United States. Control of piñon-juniper woodlands by mechanical treatments and prescribed fire are commonly applied to recover sagebrush steppe rangelands. Recently, the Sage Grouse Initiative has made conifer removal a major part of its program to reestablish sagebrush habitat for sage grouse (Centrocercus urophasianus) and other species. We analyzed data sets from previous and ongoing studies across the Great Basin characterizing cover response of perennial and annual forbs that are consumed by sage grouse to mechanical, prescribed fire, …
The Paradoxes Of Public Philosophy, Brian Leiter
A Fresh Look At Plausibility Pleading, William Hubbard
Antibacterial Derivatives Of Marine Algae: An Overview Of Pharmacological Mechanisms And Applications, Emer Shannon, Nissreen Abu-Ghannam
Antibacterial Derivatives Of Marine Algae: An Overview Of Pharmacological Mechanisms And Applications, Emer Shannon, Nissreen Abu-Ghannam
Articles
The marine environment is home to a taxonomically diverse ecosystem. Organisms such as algae, molluscs, sponges, corals, and tunicates have evolved to survive the high concentrations of infectious and surface-fouling bacteria that are indigenous to ocean waters. Both macroalgae (seaweeds) and microalgae (diatoms) contain pharmacologically active compounds such as phlorotannins, fatty acids, polysaccharides, peptides, and terpenes which combat bacterial invasion. The resistance of pathogenic bacteria to existing antibiotics has become a global epidemic. Marine algae derivatives have shown promise as candidates in novel, antibacterial drug discovery. The efficacy of these compounds, their mechanism of action, applications as antibiotics, disinfectants, and …
Human Mitochondrial Dna Replication Machinery And Disease., Matthew J Young, William C Copeland
Human Mitochondrial Dna Replication Machinery And Disease., Matthew J Young, William C Copeland
Articles
The human mitochondrial genome is replicated by DNA polymerase γ in concert with key components of the mitochondrial DNA (mtDNA) replication machinery. Defects in mtDNA replication or nucleotide metabolism cause deletions, point mutations, or depletion of mtDNA. The resulting loss of cellular respiration ultimately induces mitochondrial genetic diseases, including mtDNA depletion syndromes (MDS) such as Alpers or early infantile hepatocerebral syndromes, and mtDNA deletion disorders such as progressive external ophthalmoplegia, ataxia-neuropathy, or mitochondrial neurogastrointestinal encephalomyopathy. Here we review the current literature regarding human mtDNA replication and heritable disorders caused by genetic changes of the POLG, POLG2, Twinkle, RNASEH1, DNA2, and …
Evaluation Of Cytotoxicity Profile And Intracellular Localisation Of Doxorubicin-Loaded Chitosan Nanoparticles, Gabriele Dadalt Souto, Zeineb Farhane, Esen Efeoglu, Alan Casey, Jennifer Mcintyre, Hugh Byrne
Evaluation Of Cytotoxicity Profile And Intracellular Localisation Of Doxorubicin-Loaded Chitosan Nanoparticles, Gabriele Dadalt Souto, Zeineb Farhane, Esen Efeoglu, Alan Casey, Jennifer Mcintyre, Hugh Byrne
Articles
In the emerging field of nanomedicine, targeted delivery of nanoparticle encapsulated active pharmaceutical ingredients (API) is seen as a potential significant development, promising improved pharmacokinetics and reduced side effects. In this context, understanding the cellular uptake of the nanoparticles and subsequent subcellular distribution of the API is of critical importance. Doxorubicin (DOX) was encapsulated within chitosan nanoparticles to investigate its intracellular delivery in A549 cells in vitro. Unloaded (CS-TPP) and doxorubicin-loaded (DOX-CS-TPP) chitosan nanoparticles were characterised for size (473±41 nm), polydispersity index (0.3±0.2), zeta potential (34±4 mV), drug content (76±7 µM) and encapsulation efficiency (95±1%). The cytotoxic response to …
Gold Nanoprisms As A Hybrid In Vivo Cancer Heranostic Platform For In Situ Photoacoustic Imaging, Angiography, And Localized Hyperthermia, Chenchen Bao, Joao Conde, Fei Pan, Chao Li, Chunlei Zhang, Furong Tian, Shujing Liang, Jesus M. De La Fuente, Daxiang Cui
Gold Nanoprisms As A Hybrid In Vivo Cancer Heranostic Platform For In Situ Photoacoustic Imaging, Angiography, And Localized Hyperthermia, Chenchen Bao, Joao Conde, Fei Pan, Chao Li, Chunlei Zhang, Furong Tian, Shujing Liang, Jesus M. De La Fuente, Daxiang Cui
Articles
The development of high-resolution nanosized photoacoustic contrast agents is an exciting yet challenging technological advance. Herein, antibody (breast cancer-associated antigen 1 (Brcaa1) monoclonal antibody)- and peptide (RGD)- functionalized gold nanoprisms (AuNprs) were used as a combinatorial methodology for in situ photoacoustic imaging, angiography, and localized hyperthermia using orthotopic and subcutaneous murine gastric carcinoma models. RGD-conjugated PEGylated AuNprs are available for tumor angiography, and Brcaa1 monoclonal antibody-conjugated PEGylated AuNprs are used for targeting and for in situ imaging of gastric carcinoma in orthotopic tumor models. In situ photoacoustic imaging allowed for anatomical and functional imaging at the tumor site. In vivo …
Novel Mitochondrial Complex I Inhibitors Restore Glucose-Handling Abilities Of High-Fat Fed Mice, Darren Martin, Siobhan Leonard, Robert Devine, Clara Redondo, Gemma Kinsella, Conor Breen, Victoria Mceneaney, Mary Rooney, Tim Munsey, Richard Porter, Asipu Sivaprasadarao, John Stephens, John Findlay
Novel Mitochondrial Complex I Inhibitors Restore Glucose-Handling Abilities Of High-Fat Fed Mice, Darren Martin, Siobhan Leonard, Robert Devine, Clara Redondo, Gemma Kinsella, Conor Breen, Victoria Mceneaney, Mary Rooney, Tim Munsey, Richard Porter, Asipu Sivaprasadarao, John Stephens, John Findlay
Articles
Metformin is the main drug of choice for treating type 2 diabetes, yet the therapeutic regimens and side effects of the compound are all undesirable and can lead to reduced compliance. The aim of this study was to elucidate the mechanism of action of two novel compounds which improved glucose handling and weight gain in mice on a high-fat diet. Wildtype C57Bl/6 male mice were fed on a high-fat diet and treated with novel, anti-diabetic compounds. Both compounds restored the glucose handling ability of these mice. At a cellular level, these compounds achieve this by inhibiting complex I activity in …
Chemotherapeutic Efficiency Of Drugs In Vitro: Comparison Of Doxorubicin Exposure In 3d And 2d Culture Matrices, Alan Casey, Mahmoud Gargotti, Franck Bonnier, Hugh Byrne
Chemotherapeutic Efficiency Of Drugs In Vitro: Comparison Of Doxorubicin Exposure In 3d And 2d Culture Matrices, Alan Casey, Mahmoud Gargotti, Franck Bonnier, Hugh Byrne
Articles
The interest in the use of 3D matrices for in vitro analysis, with a view to increasing the relevance of in vitro studies and reducing the dependence on in vivo studies, has been growing in recent years. Cells grown in a 3D in vitro matrix environment have been reported to exhibit significantly different properties to those in a conventional 2D culture environment. However, comparison of 2D and 3D cell culture models have recently been noted to result in differing responses of cytotoxic assays, without any associated change in viability. The effect was attributed to differing conversion rates and effective concentrations …
How The Fourth Amendment And The Separation Of Powers Rise (And Fall) Together, Aziz Huq
How The Fourth Amendment And The Separation Of Powers Rise (And Fall) Together, Aziz Huq
Articles
No abstract provided.
The Mutual Dependency Of Force And Law In American Foreign Policy, Richard A. Epstein, Mario Loyola
The Mutual Dependency Of Force And Law In American Foreign Policy, Richard A. Epstein, Mario Loyola
Articles
No abstract provided.
Mobilaudio – A Multimodal Content Delivery Platform For Geo-Services, James Carswell, Keith Gardiner, Charlie Cullen
Mobilaudio – A Multimodal Content Delivery Platform For Geo-Services, James Carswell, Keith Gardiner, Charlie Cullen
Articles
Delivering high-quality context-relevant information in a timely manner is a priority for location-based services (LBS) where applications require an immediate response based on spatial interaction. Previous work in this area typically focused on ever more accurately determining this interaction and informing the user in the customary graphical way using the visual modality. This paper describes the research area of multimodal LBS and focuses on audio as the key delivery mechanism. This new research extends familiar graphical information delivery by introducing a geoservices platform for delivering multimodal content and navigation services. It incorporates a novel auditory user interface (AUI) that enables …
Manufacturing Barriers To Biologics Competition And Innovation, W. Nicholson Price Ii., Arti K. Rai
Manufacturing Barriers To Biologics Competition And Innovation, W. Nicholson Price Ii., Arti K. Rai
Articles
As finding breakthrough small-molecule drugs becomes more difficult, drug companies are increasingly turning to "large molecule" biologics. Although biologics represent many of the most promising new therapies for previously intractable diseases, they are extremely expensive. Moreover, the pathway for generic-type competition set up by Congress in 2010 is unlikely to yield significant cost savings. This Article provides a fresh diagnosis of and prescription for this major public policy problem. It argues that the key cause is pervasive trade secrecy in the complex area of biologics manufacturing. Under the current regime, this trade secrecy, combined with certain features of Food and …
Recent Advances In Optical Diagnosis Of Oral Cancers: Review And Future Perspectives, Ola Ibrahim, Hugh Byrne, Fiona Lyng, Surya Singh, Jopi Mikkonen, Arto Koistinen, Arja Kullaa
Recent Advances In Optical Diagnosis Of Oral Cancers: Review And Future Perspectives, Ola Ibrahim, Hugh Byrne, Fiona Lyng, Surya Singh, Jopi Mikkonen, Arto Koistinen, Arja Kullaa
Articles
Optical diagnosis techniques offer several advantages over traditional approaches, including objectivity, speed and cost, and these label-free, non-invasive methods have the potential to change the future work-flow of cancer management. The oral cavity is particularly accessible and thus such methods may serve as alternate/adjunct tools to traditional methods. Recently, in vivo human clinical studies have been initiated with a view to clinical translation of such technologies. A comprehensive review of optical methods in oral cancer diagnosis is presented. Following an introduction to the epidemiology and aetiological factors associated with oral cancers currently employed diagnostic methods and their limitations are presented. …
Homeostatic Signaling By Cell-Cell Junctions And Its Dysregulation During Cancer Progression., Yang Yu, Randolph C Elble
Homeostatic Signaling By Cell-Cell Junctions And Its Dysregulation During Cancer Progression., Yang Yu, Randolph C Elble
Articles
The transition of sessile epithelial cells to a migratory, mesenchymal phenotype is essential for metazoan development and tissue repair, but this program is exploited by tumor cells in order to escape the confines of the primary organ site, evade immunosurveillance, and resist chemo-radiation. In addition, epithelial-to-mesenchymal transition (EMT) confers stem-like properties that increase efficiency of colonization of distant organs. This review evaluates the role of cell-cell junctions in suppressing EMT and maintaining a quiescent epithelium. We discuss the conflicting data on junctional signaling in cancer and recent developments that resolve some of these conflicts. We focus on evidence from breast …
Endonuclease Activities Of Mutlα And Its Homologs In Dna Mismatch Repair., Lyudmila Y Kadyrova, Farid A Kadyrov
Endonuclease Activities Of Mutlα And Its Homologs In Dna Mismatch Repair., Lyudmila Y Kadyrova, Farid A Kadyrov
Articles
MutLα is a key component of the DNA mismatch repair system in eukaryotes. The DNA mismatch repair system has several genetic stabilization functions. Of these functions, DNA mismatch repair is the major one. The loss of MutLα abolishes DNA mismatch repair, thereby predisposing humans to cancer. MutLα has an endonuclease activity that is required for DNA mismatch repair. The endonuclease activity of MutLα depends on the DQHA(X)2E(X)4E motif which is a part of the active site of the nuclease. This motif is also present in many bacterial MutL and eukaryotic MutLγ proteins, DNA mismatch repair system factors that are homologous …