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Articles 1021 - 1050 of 2753
Full-Text Articles in Entire DC Network
Atypical Visual And Somatosensory Adaptation In Schizophrenia-Spectrum Disorders, Gizely Andrade, John Butler, Gregory Peter, Sophie Molholm, John J. Foxe
Atypical Visual And Somatosensory Adaptation In Schizophrenia-Spectrum Disorders, Gizely Andrade, John Butler, Gregory Peter, Sophie Molholm, John J. Foxe
Articles
Neurophysiological investigations in patients with schizophrenia consistently show early sensory processing deficits in the visual system. Importantly, comparable sensory deficits have also been established in healthy first-degree biological relatives of patients with schizophrenia and in first-episode drug-naive patients. The clear implication is that these measures are endophenotypic, related to the underlying genetic liability for schizophrenia. However, there is significant overlap between patient response distributions and those of healthy individuals without affected first-degree relatives. Here we sought to develop more sensitive measures of sensory dysfunction in this population, with an eye to establishing endophenotypic markers with better predictive capabilities. We used …
Rendering That Darkness At The Heart Of Priesthood : The Strangled Impulse By William King, Eamon Maher
Rendering That Darkness At The Heart Of Priesthood : The Strangled Impulse By William King, Eamon Maher
Articles
No abstract provided.
John Mcgahern : His Time And His Places, Eamon Maher, Paul Butler
John Mcgahern : His Time And His Places, Eamon Maher, Paul Butler
Articles
This article arose out of a collaboration between the two authors, Eamon Maher, a McGahern “expert,” and Paul Butler, a photographer who moved to Leitrim in the 1990s and who has been accumulating a pictorial narrative of McGahern’s home county ever since. As part of the Red Rua book festival in 2013, the authors decided to do an illustrated talk on McGahern’s work that would go alongside Paul’s exhibition, Still, which is a combination of images and text revolving around the writer’s native county.
Heritage Sites And Schoolchildren: Insights From The Battle Of The Boyne, Dervilia Roche, Bernadette Quinn
Heritage Sites And Schoolchildren: Insights From The Battle Of The Boyne, Dervilia Roche, Bernadette Quinn
Articles
Children are very much under-represented in heritage tourism studies, particularly in terms of their own perspectives. This exploratory study begins to redress this imbalance by investigating how 34 primary school-going children experience and make sense of the Battle of the Boyne Visitor Centre, an Irish heritage site. Among the research questions posed are: How does the group make sense of heritage? Where do they get their ideas about heritage attractions? What appeals to them about heritage attractions? The research adopted an interpretivist approach and employed a variety of innovative data collection tools, gathering ideas from the children through discussions, writing, …
Iron Acquisition In The Cystic Fibrosis Lung And Potential For Novel Therapeutic Strategies, Jean Tyrrell, Máire Callaghan
Iron Acquisition In The Cystic Fibrosis Lung And Potential For Novel Therapeutic Strategies, Jean Tyrrell, Máire Callaghan
Articles
Iron acquisition is vital to microbial survival and is implicated in the virulence of many of the pathogens that reside in the cystic fibrosis (CF) lung. The multifaceted nature of iron acquisition by both bacterial and fungal pathogens encompasses a range of conserved and species-specific mechanisms, including secretion of iron-binding siderophores, utilization of siderophores from other species, release of iron from host iron-binding proteins and haemoproteins, and ferrous iron uptake. Pathogens adapt and deploy specific systems depending on iron availability, bioavailability of the iron pool, stage of infection and presence of competing pathogens. Understanding the dynamics of pathogen iron acquisition …
Mind The Analytical Gap! Tracing A Fault Line In Daubert, Susan Haack
Mind The Analytical Gap! Tracing A Fault Line In Daubert, Susan Haack
Articles
No abstract provided.
Prospects For Subunit Vaccines: Technology Advances Resulting In Efficacious Antigens Requires Matching Advances In Early Clinical Trial Investment, Siobhan Mcclean
Prospects For Subunit Vaccines: Technology Advances Resulting In Efficacious Antigens Requires Matching Advances In Early Clinical Trial Investment, Siobhan Mcclean
Articles
With the continued march of antimicrobial resistance, a renewed impetus for better vaccines has been heralded. Identification of potent subunit vaccines has been greatly facilitated by recent developments in reverse vaccinology and proteomics strategies. There are a range of antimicrobial resistant bacterial pathogens that could be targeted by potent vaccine antigens identified within the coming years. However, cost is a significant hurdle in progressing lead antigen candidates to clinical trials. In order for novel vaccine technologies to realize their clinical potential, there is a requirement to improve investment and incentives to expedite the development of vaccines that are apparently efficacious …
Enhancing Conservation Options: An Argument For Statutory Recognition Of Options To Purchase Conservation Easements (Opces), Federico Cheever, Jessica Owley
Enhancing Conservation Options: An Argument For Statutory Recognition Of Options To Purchase Conservation Easements (Opces), Federico Cheever, Jessica Owley
Articles
Land conservation transactions have been the most active component of the conservation movement in the United States for the past three decades. Conservation organizations have acquired property rights-mostly conservation easements-to protect roughly 40 million acres of land nationwide. However, climate change threatens this vast edifice. Climate change means that the resources that land conservation transactions were intended to protect may not persist on the land protected. Options to purchase conservation easements ("OPCEs") have long played a modest but important role in conservation law practice. In the world climate change is creating, with its substantial uncertainties and shifting windows of opportunity, …
Strategic Rulemaking Disclosure, Jennifer Nou, Jed Stiglitz
Strategic Rulemaking Disclosure, Jennifer Nou, Jed Stiglitz
Articles
No abstract provided.
The Supreme Court As A Filter Between International Law And American Constitutionalism, Curtis A. Bradley
The Supreme Court As A Filter Between International Law And American Constitutionalism, Curtis A. Bradley
Articles
This Essay describes and defends the Supreme Court’s role as a filter between international law and the American constitutional system. In this role,the Court ensures that when international law passes into the U.S. legal system, it does so in a manner consistent with domestic constitutional values. This filtering role is appropriate, the Essay explains, in light of the different processes used to generate international law and domestic law and the different functions served by these bodies of law. The Essay provides examples of this filtering role in four scenarios: the intersection of treaties and individual rights; the relationship between the …
Judicial Lawmaking And General Principles Of Law In International Criminal Law, Neha Jain
Judicial Lawmaking And General Principles Of Law In International Criminal Law, Neha Jain
Articles
General principles of law are a primary mechanism for “gap-filling” in international criminal law. However, their interpretation by tribunals has been fitful, contradictory, and misguided. Given that general principles have been used to settle crucial legal issues that affect the rights of the accused, the confusion concerning their application threatens the legitimacy of international criminal justice. This Article critiques the various conceptions of general principles developed by scholars and tribunals based on the criteria of formal and material validity and exposes the problems with their application in light of comparative law and criminal law theory. The Article challenges international criminal …
The Rhetoric Of Negative Externalities, Claire Hill
The Rhetoric Of Negative Externalities, Claire Hill
Articles
The concept of negative externalities is firmly entrenched in economic analysis even though it is almost impossible to apply with any rigor in many important real-world contexts. For instance, what is the baseline from which “pollution” is measured? How clean must the air and water surrounding the firm be? And whose costs must the firm take into account in order to internalize the externalities? Clearly, the firm’s next door neighbors harmed by the polluted air generated by the firm. But what about people who are more remotely affected? There is no neutral way to set the baseline below which deviations …
Enhanced Cognition And Hypoglutamatergic Signaling In A Growth Hormone Receptor Knockout Mouse Model Of Successful Aging., Kevin N Hascup, Mary K Lynn, Patrick J Fitzgerald, Shari Randall, John J Kopchick, Heather A Boger, Andrzej Bartke, Erin R Hascup
Enhanced Cognition And Hypoglutamatergic Signaling In A Growth Hormone Receptor Knockout Mouse Model Of Successful Aging., Kevin N Hascup, Mary K Lynn, Patrick J Fitzgerald, Shari Randall, John J Kopchick, Heather A Boger, Andrzej Bartke, Erin R Hascup
Articles
Growth hormone receptor knockout (GHR-KO) mice are long lived with improved health span, making this an excellent model system for understanding biochemical mechanisms important to cognitive reserve. The purpose of the present study was to elucidate differences in cognition and glutamatergic dynamics between aged (20- to 24-month-old) GHR-KO and littermate controls. Glutamate plays a critical role in hippocampal learning and memory and is implicated in several neurodegenerative disorders, including Alzheimer's disease. Spatial learning and memory were assessed using the Morris water maze (MWM), whereas independent dentate gyrus (DG), CA3, and CA1 basal glutamate, release, and uptake measurements were conducted in …
Soluble Amyloid-Β42 Stimulates Glutamate Release Through Activation Of The Α7 Nicotinic Acetylcholine Receptor., Kevin N Hascup, Erin R Hascup
Soluble Amyloid-Β42 Stimulates Glutamate Release Through Activation Of The Α7 Nicotinic Acetylcholine Receptor., Kevin N Hascup, Erin R Hascup
Articles
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by progressive memory loss and hippocampal atrophy. Soluble amyloid-β (Aβ)42 and plaque accumulation is implicated as the neurotoxic species in this disorder; however, at physiological concentrations (pM-nM), Aβ42 contributes to neurogenesis, long-term potentiation, and neuromodulation. Because Aβ42 binds the α7 nicotinic acetylcholine receptors (α7nAChRs) located presynaptically on glutamatergic terminals, involved with hippocampal dependent learning and memory, we examined the effects of the human, monomeric isoform of Aβ42 on glutamate release in the dentate gyrus (DG), CA3, and CA1, of isoflurane anesthetized, 6-9 month old male C57BL/6J mice. We utilized an enzyme-based …
The Prosecutor's Duty To "Imperfect" Rape Victims, Tamara Rice Lave
The Prosecutor's Duty To "Imperfect" Rape Victims, Tamara Rice Lave
Articles
No abstract provided.
Linocin And Ompw Are Involved In Attachment Of The Cystic Fibrosis-Associated Pathogen Burkholderia Cepacia Complex To Lung Epithelial Cells And Protect Mice Against Infection, Siobhan Mcclean, Marc Healy, Cassandra Collins, Stephen Carberry, Luke O'Shaughnessy, Ruth Dennehy, Aine Adams Aine Adams, Helen Kennelly, Jennifer Corbett, Fiona Carty, Laura Ann Cahill, Máire Callaghan, Karen English, Bernard P. Mahon, Sean Doyle, Minu Shinoy
Linocin And Ompw Are Involved In Attachment Of The Cystic Fibrosis-Associated Pathogen Burkholderia Cepacia Complex To Lung Epithelial Cells And Protect Mice Against Infection, Siobhan Mcclean, Marc Healy, Cassandra Collins, Stephen Carberry, Luke O'Shaughnessy, Ruth Dennehy, Aine Adams Aine Adams, Helen Kennelly, Jennifer Corbett, Fiona Carty, Laura Ann Cahill, Máire Callaghan, Karen English, Bernard P. Mahon, Sean Doyle, Minu Shinoy
Articles
Burkholderia cepacia complex (Bcc) causes chronic opportunistic lung infections in people with cystic fibrosis (CF) resulting in a gradual lung function decline and, ultimately, patient death. Bcc is a complex of eighteen species and is rarely eradicated once a patient is colonised, therefore vaccination may represent a better therapeutic option. We developed a new proteomics approach to identify bacterial proteins that are involved in attachment of Bcc to lung epithelial cells. Fourteen proteins were reproducibly identified by 2-DE from four Bcc strains, representative of two Bcc species: B. cenocepacia, the most virulent and B. multivorans, the most frequently acquired. Seven …
Delayed Valuation: A Reanalysis Of Goal Features, “Upwards” Complementizer Agreement, And The Mechanics Of Case, Vicki Carstens
Delayed Valuation: A Reanalysis Of Goal Features, “Upwards” Complementizer Agreement, And The Mechanics Of Case, Vicki Carstens
Articles
There are at least four opposing views on the directionality and configuration of Agree relations. In mainstream Minimalism, Agree is strictly downward “probing” (Chomsky 2000, 2001, Boskovic 2007, Epstein & Seely 2006), but some recent works argue instead that Agree always looks upwards (Zeijlstra 2012; Wurmbrand 2012). A third perspective takes agreement to follow from the Spec, head configuration (Koopman 2006; and see Chomsky’s 2013 labeling through shared prominent features), and under a fourth proposal, the directionality of Agree varies parametrically (Baker 2008). While each of these approaches has some empirical support, none achieves the strict conceptual necessity that is …
Whole Mount Dissection And Immunofluorescence Of The Adult Mouse Cochlea., Scott C Montgomery, Brandon C Cox
Whole Mount Dissection And Immunofluorescence Of The Adult Mouse Cochlea., Scott C Montgomery, Brandon C Cox
Articles
The organ of Corti, housed in the cochlea of the inner ear, contains mechanosensory hair cells and surrounding supporting cells which are organized in a spiral shape and have a tonotopic gradient for sound detection. The mouse cochlea is approximately 6 mm long and often divided into three turns (apex, middle, and base) for analysis. To investigate cell loss, cell division, or mosaic gene expression, the whole mount or surface preparation of the cochlea is useful. This dissection method allows visualization of all cells within the organ of Corti when combined with immunostaining and confocal microscopy to image cells at …
Afterword: Kindling The Programmatic Production Of Critical And Outsider Legal Scholarship, 1996-2016, Sarudzayi M. Matambanadzo, Francisco Valdes, Sheila Velez
Afterword: Kindling The Programmatic Production Of Critical And Outsider Legal Scholarship, 1996-2016, Sarudzayi M. Matambanadzo, Francisco Valdes, Sheila Velez
Articles
No abstract provided.
Agora, Dignity, And Discrimination: On The Constitutional Shortcomings Of Conscience Laws That Promote Inequality In The Public Marketplace Symposium: Law And Religion In An Increasingly Polarized America, Ronald J. Krotoszynski Jr.
Agora, Dignity, And Discrimination: On The Constitutional Shortcomings Of Conscience Laws That Promote Inequality In The Public Marketplace Symposium: Law And Religion In An Increasingly Polarized America, Ronald J. Krotoszynski Jr.
Articles
No abstract provided.
The Rise And Fall Of Plausibility Pleading, Adam N. Steinman
The Rise And Fall Of Plausibility Pleading, Adam N. Steinman
Articles
No abstract provided.
Contemporary Practice Of The United States Relating To International Law, July 2016, Kristina Daugirdas, Julian Davis Mortenson
Contemporary Practice Of The United States Relating To International Law, July 2016, Kristina Daugirdas, Julian Davis Mortenson
Articles
In this section: • U.S. Supreme Court Upholds Law Facilitating Compensation for Victims of Iranian Terrorism • Russia Argues Enhanced Military Presence in Europe Violates NATO-Russia Agreement; United States Criticizes Russian Military Maneuvers over the Baltic Sea as Inconsistent with Bilateral Treaty Governing Incidents at Sea • U.S. Secretary of State Determines ISIL Is Responsible for Genocide • United States Blocks Reappointment of WTO Appellate Body Member • U.S. Department of Defense Releases Report of Investigation Finding That October 2015 Air Strike on Doctors Without Borders Hospital in Kunduz, Afghanistan, Was Not a War Crime • United States Expands Air …
Is Theocracy Our Politics? Thoughts On William Baude's 'Is Originalism Our Law?', Richard A. Primus
Is Theocracy Our Politics? Thoughts On William Baude's 'Is Originalism Our Law?', Richard A. Primus
Articles
In Is Originalism Our Law?, William Baude has made a good kind of argument in favor of originalism. Rather than contending that originalism is the only coherent theory for interpreting a constitution, he makes the more modest claim that it happens to be the way that American judges interpret our Constitution. If he is right—if originalism is our law—then judges deciding constitutional cases ought to be originalists. But what exactly would the content of that obligation be? Calling some interpretive method “our law” might suggest that judges have an obligation to decide cases by reference to that method. But the …
Commentary On The Emerging Constitutional Indigenous Peoples Land Rights In Tanzania, Daniel Halberstam
Commentary On The Emerging Constitutional Indigenous Peoples Land Rights In Tanzania, Daniel Halberstam
Articles
The pastoralists and hunter-gatherer indigenous peoples in Tanzania continue lobbying their recognition as such and protection of their land rights. This article discusses the extent to which the indigenous peoples are legally recognized and the state of their security of land tenure. With the hindsight of the UN Declaration on the Rights of Indigenous Peoples 2007 and the 2003 Report of the African Commission Working Group of Experts on Indigenous Population, this article probes the emerging indigenous land rights within the broader understating of the minority rights in the Draft Constitution of Tanzania 2014 as well as the Draft Policy …
Interactive Learning: Developing An Esimulation Portal Framework, Ayman Tobail, John Crowe, Amr Arisha
Interactive Learning: Developing An Esimulation Portal Framework, Ayman Tobail, John Crowe, Amr Arisha
Articles
The emerging eLearning paradigm is becoming increasingly used in many academic disciplines. The concept acknowledges learning processes that no longer deploy only traditional teaching methods. It can be argued that today’s third level education students are part of a new virtual era where the blackboard has been replaced by the interactive whiteboard, so more interactive and virtually orientated teaching aids are required to assist in the transition from traditional learning to eLearning. The key objective of this paper is to propose a simulation-based learning framework that integrates web-based simulation and a web content management hierarchy model. Using the highly complex …
Interactive Learning: Developing An Esimulation Portal Framework, Ayman Tobail, John Crowe, Amr Arisha
Interactive Learning: Developing An Esimulation Portal Framework, Ayman Tobail, John Crowe, Amr Arisha
Articles
The emerging eLearning paradigm is becoming increasingly used in many academic disciplines. The concept acknowledges learning processes that no longer deploy only traditional teaching methods. It can be argued that today’s third level education students are part of a new virtual era where the blackboard has been replaced by the interactive whiteboard, so more interactive and virtually orientated teaching aids are required to assist in the transition from traditional learning to eLearning. The key objective of this paper is to propose a simulation-based learning framework that integrates web-based simulation and a web content management hierarchy model. Using the highly complex …
Atmospheric Cold Plasma Interactions With Modified Atmosphere Packaging Inducer Gases For Safe Food Preservation., Lu Han, Daniela Boehm, Vladimir Milosavljević, Ester Amias, Patrick J. Cullen, Paula Bourke
Atmospheric Cold Plasma Interactions With Modified Atmosphere Packaging Inducer Gases For Safe Food Preservation., Lu Han, Daniela Boehm, Vladimir Milosavljević, Ester Amias, Patrick J. Cullen, Paula Bourke
Articles
Diverse microbiological challenges and pervasive microbial resistance drive technological development in food processing, where increasing process complexity and consumer demand for less processed goods leads to strong demand for effective decontamination. Atmospheric cold plasma (ACP) has wide potential for decontamination application in the food sector. We investigated the effect of Modified Atmosphere Packaging (MAP) gas mixtures on reactive species generated, their efficacy and mechanism of inactivation against Escherichia coli, Listeria monocytogenes and Staphylococcus aureus. Oxygen levels in the applied working gas had positive interactive effects on ROS generation, in-package inactivation efficacy in conjunction with post-treatment storage time. …
Frankenfolk: Distinctiveness And Attractiveness Of Voice And Motion, Jan Ondřej, Cathy Ennis, Niamh Merriman, Carol O'Sullivan
Frankenfolk: Distinctiveness And Attractiveness Of Voice And Motion, Jan Ondřej, Cathy Ennis, Niamh Merriman, Carol O'Sullivan
Articles
It is common practice in movies and games to use different actors for the voice and body/face motion of a virtual character. What effect does the combination of these different modalities have on the perception of the viewer? In this article, we conduct a series of experiments to evaluate the distinctiveness and attractiveness of human motions (face and body) and voices. We also create combination characters called FrankenFolks, where we mix and match the voice, body motion, face motion, and avatar of different actors and ask which modality is most dominant when determining distinctiveness and attractiveness or whether the effects …
Silver Nanoparticles Induce Pro-Inflammatory Gene Expression And Inflammasome Activation In Human Monocytes, A. Murphy, A. Casey, G. Byrne, Gordon Chambers, Orla L. Howe
Silver Nanoparticles Induce Pro-Inflammatory Gene Expression And Inflammasome Activation In Human Monocytes, A. Murphy, A. Casey, G. Byrne, Gordon Chambers, Orla L. Howe
Articles
A complete cytotoxic profile of exposure to silver (AgNP) nanoparticles investigating their biological effects on the innate immune response of circulating white blood cells is required to form a complete understanding of the risk posed. This was explored by measuring AgNP-stimulated gene expression of the pro-inflammatory cytokines interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in THP-1 monocytes. A further study, on human monocytes extracted from a cohort of blood samples, was carried out to compare with the AgNP immune response in THP-1 cells along with the detection of pro-IL-1β which is a key mediator of the inflammasome complex. …
Rebellious Pedagogy And Practice, Anthony V. Alfieri
Rebellious Pedagogy And Practice, Anthony V. Alfieri
Articles
Gerald Lopez's ground breaking book, Rebellious Lawyering: One Chicano's Vision of Progressive Law Practice, introduced new critical pathways and perspectives for clinical educators to better understand and enhance their advocacy, teaching, and scholarship. Indeed, Lopez's interdisciplinary investigation of the local, sociocultural context of the lawyering process produced a marked shift in both the pedagogy and the practice of public interest law, particularly civil rights and poverty law. A quarter century after its publication, Rebellious Lawyering stands out not only for its contextual critique of lawyering theory and practice, but also for its multifaceted integration of law, cultural studies, race …