Digital Commons Network^™

“Be A Pattern For The World”: The Development Of A Dark Patterns Detection Tool To Prevent Online User Loss, Jordan Donnelly, Alan Dowley, Yunpeng Liu, Yufei Su, Quanwei Sun, Lan Zeng, Andrea Curley, Damian Gordon, Paul Kelly, Dympna O'Sullivan, Anna Becevel

Articles

Dark Patterns are designed to trick users into sharing more information or spending more money than they had intended to do, by configuring online interactions to confuse or add pressure to the users. They are highly varied in their form, and are therefore difficult to classify and detect. Therefore, this research is designed to develop a framework for the automated detection of potential instances of web-based dark patterns, and from there to develop a software tool that will provide a highly useful defensive tool that helps detect and highlight these patterns.

Against Progress: Intellectual Property And Fundamental Values In The Internet Age, Or Cohen Sasson

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No abstract provided.

Physiognomic Artificial Intelligence, Luke Stark, Jevan Hutson

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The reanimation of the pseudosciences of physiognomy and phrenology at scale through computer vision and machine learning is a matter of urgent concern. This Article—which contributes to critical data studies, consumer protection law, biometric privacy law, and antidiscrimination law—endeavors to conceptualize and problematize physiognomic artificial intelligence (“AI”) and offer policy recommendations for state and federal lawmakers to forestall its proliferation.

Physiognomic AI, as this Article contends, is the practice of using computer software and related systems to infer or create hierarchies of an individual’s body composition, protected class status, perceived character, capabilities, and future social outcomes based on their physical …

Potential Psychoactive Effects Of Microalgal Bioactive Compounds For The Case Of Sleep And Mood Regulation: Opportunities And Challenges, Bozena Mccarthy, Graham O’Neill Dr, Nissreen Abu-Ghannam Prof.

Articles

Sleep deficiency is now considered an emerging global epidemic associated with many serious health problems, and a major cause of financial and social burdens. Sleep and mental health are closely connected, further exacerbating the negative impact of sleep deficiency on overall health and well-being. A major drawback of conventional treatments is the wide range of undesirable side-effects typically associated with benzodiazepines and antidepressants, which can be more debilitating than the initial disorder. It is therefore valuable to explore the efficiency of other remedies for complementarity and synergism with existing conventional treatments, leading to possible reduction in undesirable side-effects. This review …

Developing A Customised Note By Note Prototype Recipe Which Can Be 3d Printed, Roisin Burke, Pauline Danaher

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Note by Note (NbN) cooking and 3D food printing individually and in combination allow for the creation of customized foods. A NbN recipe was developed and printed using a Procusini 3.0, 3D food printer. The recipe was adapted from a commercial powdered pastry dough recipe, to create two versions of a prototype food, containing in each case a different plant-based protein, i.e., soya (Glycine max L.) or hemp (Cannabis sativa). The printed foods were identical in shape and had a crisp consistency following cooking. They had different colours and contained different proteins in the amounts of 10.3 % of soya …

Freedom From Speech, Mary Anne Franks

Articles

The importance of freedom of speech in a democratic society is usually taken as a given, but freedom from speech is no less important in safeguarding the values of truth, autonomy, and democracy. Freedom from speech includes both the right of the individual to not be forced to speak and the freedom to avoid the speech of others. This essay attempts to highlight the significance of freedom from speech in order to clarify the importance of the First Amendment right against compelled speech; provide an explanation for when the right of free speech yields to other rights; and offer a …

Afterword: Latcrit At Twenty-Five And Beyond, Part Ii - Challenges And/As Opportunities: Centering "Hybridized" Advocacy Projects In Antisubordination Praxis To Connect Campuses And Communities For Material Long-Term Progress, Francisco Valdes, Steven W. Bender, Jennifer J. Hill

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No abstract provided.

What Is A Metaphorical Collocation?, Jakob Patekar

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In research on collocations published in English we encounter, albeit rarely, the use of the notion “metaphorical collocations”. It is interesting to note that seldom if ever are metaphorical collocations defined in any way in these studies, suggesting that researchers find the term self-explanatory. However, seeing that metaphorical collocations are an exciting area of research that is yet to draw attention from the wider community ofresearchers, the aim of this paper is to analyze the current understanding of what a metaphorical collocation is by examining the theoretical foundations as well as studies, specifically those published in English (as the language …

Friend Or Foe? Defining The Role Of Glutamate In Aging And Alzheimer’S Disease, Makayla F. Cox, Erin R. Hascup, Andrzej Bartke, Kevin Hascup

Articles

Aging is a naturally occurring decline of physiological processes and biological pathways that affects both the structural and functional integrity of the body and brain. These physiological changes reduce motor skills, executive function, memory recall, and processing speeds. Aging is also a major risk factor for multiple neurodegenerative disorders including Alzheimer’s disease (AD). Identifying a biomarker, or biomarkers, that signals the transition from physiological to pathological aging would aid in earlier therapeutic options or interventional strategies. Considering the importance of glutamate signaling in synaptic plasticity, motor movement, and cognition, this neurotransmitter serves as a juncture between cognitive health and disease. …

Devotee/Ethnographer: My Struggle At The Boundary Walls Of Participant Observation, Atreyee Majumder

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This article demonstrates the difficulty of incorporating within the methodological ambit of ‘participant observation’, a possibility of the ethnographer herself staking claim in the religious truth claims of the community that constitute the subject of research. In so doing, this article provides a critique of the concept of participant observation to point out that participant observation anticipates the work of the ethnographer in participating in the physical, performative lives of the community that she purports to study, but never the internal life, especially the life of accessing a register of truth. I found myself in a curious situation as a …

Mapping The Restoration Of Degraded Peatland As A Field Of Research Area: A Scientometric Review, Samuel Obeng Apori, Douglas Mcmillan, Michelle Giltrap, Furong Tian

Articles

Degraded peatland reduced many ecosystem services such as water quality and quantity, biodiversity, carbon storage, climate regulations and other cultural benefits. Therefore, several initiatives for the restoration of degraded peatland (RDP) have been attempted to restore the ecosystem processes, productivity and services of the degraded peatland to its original natural condition. Notwithstanding the popularity of RDP research among researchers and industry practitioners, a quantitative technique to map a comprehensive survey of the intellectual core and the general body landscape of knowledge on RDP research does not exist. In this study, a scientometric analysis was employed to analyze 522 documents using …

Governing Open Ocean And Fish Carbon: Perspectives And Opportunities, Maartje Oostdijk, Laura G. Elsler, Paulina Ramírez-Monsalve, Kirill Orach, Mary S. Wisz

Articles

Marine life plays a vital role in the ocean’s biological pump by sequestering and mediating fluxes of carbon to the deep sea and sea floor. The roles that fish and other marine vertebrates play in the biological pump are increasingly attracting scientific and policy attention. In this paper, we investigated the interest in and possibilities for the international governance of open ocean and fish carbon ecosystem services. We used semi-structured interviews with representatives from environmental non-governmental organisations (ENGOs), policy makers, and policy experts, along with an exploratory review of grey and peer-reviewed literature to: 1) trace the pathway of important …

The Heat Is On: The Collaborations, Capacities, And Management Style Required For The Establishment And Sustainability Of Community-Owned Renewable Energy District Heating Systems In Austria, Ireland, Northern Ireland, Wales, And Scotland, Gerard Doyle

Articles

International reviews of countries’ progress at tackling climate change show that Ireland is making small levels of progress on tackling issues associated with climate change. This paper will highlight the pivotal role the State performs, both at national and local level, in creating the conditions essential for the establishment of community-owned renewable energy district heating systems. In particular, the State can provide funding for these initiatives to acquire the management and technical expertise essential for their establishment and maintenance. This paper will also examine a theoretical framework, referred to as capacity analysis, to explain the capacities that need to be …

G Protein–Coupled Receptor 21 In Macrophages: An In Vitro Study, Valentina Bordano, Gemma K. Kinsella, Stefania Cannito, Chiara Dianzani, Casimiro Luca Gigliotti, John C. Stephens, Chiara Monge, Claudia Bocca, Arianna C. Rosa, Gianluca Miglio, Umberto Dianzani, John B.C. Findlay, Elisa Benetti

Articles

GPR21 is an orphan and constitutively active receptor belonging to the superfamily of G-Protein Coupled Receptors (GPCRs). GPR21 couples to the Gq family of G proteins and is markedly expressed in macrophages. Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration. The aim of this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement in cell migration and cytokine release and (ii) the consequence of its pharmacological inhibition by using the inverse agonist GRA2. THP-1 cells were activated and differentiated into either M1 or …

Growth Hormone Signaling Shapes The Impact Of Environmental Temperature On Transcriptomic Profile Of Different Adipose Tissue Depots In Male Mice., Augusto Schneider, Berta Victoria, Maria Isabel Schiavon Cousen, Yimin Fang, Samuel Mcfadden, Justin Darcy, Adam Gesing, Erin R Hascup, Kevin N Hascup, Andrzej Bartke, Michal M Masternak

Articles

Growth hormone receptor knockout (GHRKO) mice are smaller, long living, and have an increased metabolic rate compared with normal (N) littermates. However, it is known that thermoneutral conditions (30-32°C) elicit metabolic adaptations in mice, increasing the metabolic rate. Therefore, we hypothesized that environmental temperature would affect the expression profile of different adipose tissue depots in GHRKO mice. For this, N (n = 12) and GHRKO (n = 11) male mice were maintained at 23 or 30°C from weaning until 11 months of age. RNA sequencing from adipose tissue depots (epididymal-eWAT, perirenal-pWAT, subcutaneous-sWAT, and brown fat-BAT) was performed. Thermoneutrality increased body …

Growth Hormone Signaling Shapes The Impact Of Environmental Temperature On Transcriptomic Profile Of Different Adipose Tissue Depots In Male Mice., Augusto Schneider, Berta Victoria, Maria Isabel Schiavon Cousen, Yimin Fang, Samuel Mcfadden, Justin Darcy, Adam Gesing, Erin R Hascup, Kevin N Hascup, Andrzej Bartke, Michal M Masternak

Articles

Growth hormone receptor knockout (GHRKO) mice are smaller, long living, and have an increased metabolic rate compared with normal (N) littermates. However, it is known that thermoneutral conditions (30-32°C) elicit metabolic adaptations in mice, increasing the metabolic rate. Therefore, we hypothesized that environmental temperature would affect the expression profile of different adipose tissue depots in GHRKO mice. For this, N (n = 12) and GHRKO (n = 11) male mice were maintained at 23 or 30°C from weaning until 11 months of age. RNA sequencing from adipose tissue depots (epididymal-eWAT, perirenal-pWAT, subcutaneous-sWAT, and brown fat-BAT) was performed. Thermoneutrality increased body …

Latin American Film, Mirna Vohnsen

Articles

The scholarship on Latin American film in 2020 points to a diverse and vibrant field of study that encompasses a wide range of themes. This year, the representations of indigenous peoples, as well as the studies on youth and transnationalism, have caught the attention of several scholars. Another topic that has gained importance is the revisiting of films, filmmakers, and performers from the twentieth century. Volume 17, number 2, of Studies in Spanish & Latin American Cinemas, which is devoted to Mexican documentaries from the last century, is a poignant example of this development. Aside from these topics, gender and …

In The Garden: Capacities That Contribute To Community Groups Establishing Community Gardens,, Gerard Doyle

Articles

Based on case studies in Dublin, Ireland, this paper examines the motives for individuals to establish community gardens therein. The paper also outlines the capacities required for community groups to successfully establish and sustain community gardens in Ireland. These capacities include the involvement of individuals with a range of expertise, the presence of supportive community groups/organisations and state agencies, and access to resources, including land. The research findings, detailed in this paper, indicate that community gardens in urban settings encounter a number of challenges, including the absence of a mechanism for community groups to access land. The article provides a …

Limits Of Detection Of Mycotoxins By Laminar Flow Strips: A Review, Xinyi Zhao, Hugh Byrne, Christine M. O’Connor, James Curtin, Furong Tian

Articles

Mycotoxins are secondary metabolic products of fungi. They are poisonous, carcinogenic, and mutagenic in nature and pose a serious health threat to both humans and animals, causing severe illnesses and even death. Rapid, simple and low-cost methods of detection of mycotoxins are of immense importance and in great demand in the food and beverage industry, as well as in agriculture and environmental monitoring, and, for this purpose, lateral flow immunochromatographic strips (ICSTs) have been widely used in food safety and environmental monitoring. The literature to date describing the development of ICSTs for the detection of different types of mycotoxins using …

The False Allure Of The Anti-Accumulation Principle, Michael E. Herz, Kevin M. Stack

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Today the executive branch is generally seen as the most dangerous branch. Many worry that the executive branch now defies or subsumes the separation of powers. In response, several Supreme Court Justices and prominent scholars assert that the very separation-of-powers principles that determine the structure of the federal government as a whole apply with full force within the executive branch. In particular, they argue that constitutional law prohibits the accumulation of more than one type of power—legislative, executive, and judicial—in the same executive official or government entity. We refer to this as the anti-accumulation principle. The consequences of this principle, …

Lawyering The Presidency, Deborah Pearlstein

Articles

Among its many profound effects on American life, the Trump presidency has triggered a surge of interest in the project of law reform to better check the exercise of presidential power. Yet these reform efforts arise against a wholly unsettled debate about the function and effectiveness of existing checks, perhaps none more so than the role of executive branch legal counsel. With courts often deferential, and Congress hamstrung by partisan polarization, scholars have drawn on the experiences of executive branch lawyers to assess whether counsel functions as part of an “internal separation of powers” form of constraint. Yet while these …

The Progressive Love Affair With The Carceral State, Kate Levine

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A Review of The Feminist War on Crime: The Unexpected Role of Women’s Liberation in Mass Incarceration. By Aya Gruber.

Advancing Ubiquitous Collaboration For Telehealth - A Framework To Evaluate Technology-Mediated Collaborative Workflow For Telehealth, Hypertension Exam Workflow Study, Christopher Bondy Ph.D., Linlin Chen Ph.D, Pamela Grover Md, Pengcheng Shi Ph.D

Articles

Healthcare systems are under siege globally regarding technology adoption; the recent pandemic has only magnified the issues. Providers and patients alike look to new enabling technologies to establish real-time connectivity and capability for a growing range of remote telehealth solutions. The migration to new technology is not as seamless as clinicians and patients would like since the new workflows pose new responsibilities and barriers to adoption across the telehealth ecosystem. Technology-mediated workflows (integrated software and personal medical devices) are increasingly important in patient-centered healthcare; software-intense systems will become integral in prescribed treatment plans [1]. My research explored the path to …

Understanding The Influence Of Place On Festival Making And Artistic Production In The Local Urban Festival Context, Danielle Lynch, Bernadette Quinn Dr

Articles

Recent decades have seen a dramatic increase in research output on arts festivals and cultural events, and a growing focus on the role festivals play in negotiating and constructing meanings of place. However, little attention has been paid to how place shapes the process of festival making and artistic production. This paper attempts to address this shortcoming by examining the extent to which place matters to the production of festival activity and asks: how does place influence festival making and artistic production in a local arts festival context? The study is part of ongoing qualitative research into the Five Lamps …

Contracts In The Age Of Smart Readers, Yonathan A. Arbel, Shmuel I. Becher

Articles

What does it mean to have machines that can read, explain, and evaluate contracts? Recent advances in machine learning have led to a fundamental breakthrough in machine language models, portending a profound shift in the ability of machines to process text. Such a shift has far-reaching consequences for diverse areas of law, which are predicated on, and justified by, the existence of information barriers. Our object here is to provide a general framework for evaluating the legal and policy implications of employing language models as "smart readers"-tools that read, analyze, and assess contracts, disclosures, and privacy policies.

Synthesizing state-of-the-art developments, …

Extracellular Secretion Of A Cutinase With Polyester-Degrading Potential By E. Coli Using A Novel Signal Peptide From Amycolatopsis Mediterranei, Yeqi Tan, Gemma K. Kinsella, Gary T. Henehan, Barry J. Ryan

Articles

Recent studies in this laboratory showed that an extracellular cutinase from A. mediterranei (AmCut) was able to degrade the plastics polycaprolactone and polybutylene succinate. Such plastics can be slow to degrade in soils due to a lack of efficient polyester degrading organisms. AmCut also showed potential for the biocatalytic synthesis of esters by reverse hydrolysis.

The gene for AmCut has an upstream leader sequence whose transcript is not present in the purified enzyme. In this study, we show using predictive modelling, that this sequence codes for an N-terminal signal peptide that directs transmembrane expression via the Sec secretion pathway.

E. …

The Meld Model: The Holy Grail Of Indian Corporate Jurisprudence, Rahul Singh

Articles

Is a model of a theory of Indian corporate jurisprudence effable? This paper posits that jurisprudence of Indian corporate law is desirable and possible. Given the relative nascence of the Companies Act 2013, Insolvency and Bankruptcy Code 2016 and the Competition Act 2002, this paper undergirds the possibility of jurisprudence through modelling-the meld model-which is, jurisprudentially speaking, a synthesis between 'exclusive legal positivism' and 'law and economics'. The paper instantiates the utility and desirability of the meld model through test suites - i.e. select case laws in the context of company, competition and insolvency laws. With the help of test …

Evolutionary Paths To Macrolide Resistance In A Neisseria Commensal Converge On Ribosomal Genes Through Short Sequence Duplications, Jordan C. Raisman, Michael A. Fiore, Lucille Tomin, Joseph K. O. Adjei, Virginia X. Aswad, Jonathan Chu, Christina J. Domondon, Ben A. Donahue, Claudia A. Masciotti, Connor G. Mcgrath, Jo Melita, Paul A. Podbielski, Madelyn R. Schreiner, Lauren J. Trumpore, Peter C. Wengert, Emalee A. Wrightstone, André O. Hudson, Crista B. Wadsworth

Articles

Neisseria commensals are an indisputable source of resistance for their pathogenic relatives. However, the evolutionary paths commensal species take to reduced susceptibility in this genus have been relatively underexplored. Here, we leverage in vitro selection as a powerful screen to identify the genetic adaptations that produce azithromycin resistance (� 2 μg/mL) in the Neisseria commensal, N. elongata. Across multiple lineages (n = 7/16), we find mutations that reduce susceptibility to azithromycin converge on the locus encoding the 50S ribosomal L34 protein (rpmH) and the intergenic region proximal to the 30S ribosomal S3 protein (rpsC) through short tandem duplication events. Interestingly, …

Plasma Induced Reactive Oxygen Species-Dependent Cytotoxicity In Glioblastoma 3d Tumourspheres, Janith Wanigasekara, Carlos Barcia, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin

Articles

The aim of this study was to determine the effects of a pin‐to‐plate cold atmospheric plasma (CAP) on U‐251 MG three‐dimensional (3D) glioblastoma spheroids under different conditions. 3D tumorspheres showed higher resistance to the CAP treatment compared to 2D monolayer cells. A single CAP treatment was able to induce cytotoxicity, while multiple CAP treatments augmented this effect. CAP was also able to induce cytotoxicity throughout the tumoursphere, and we identified that reactive oxygen species(ROS) plays a major role, while H2O2plays a partial role in CAP‐induced cytotoxicity in tumour-spheres. We conclude that ROS‐dependent cytotoxicity is induced uniformly throughout glioblastoma and epidermoid …

Design And Development Of Magnetic Iron Core Gold Nanoparticle-Based Fluorescent Multiplex Assay To Detect Salmonella, Xinyi Zhao

Articles

Salmonella is a bacterial pathogen which is one of the leading causes of severe illnesses in humans. The current study involved the design and development of two methods, respectively using iron oxide nanoparticle (IONP) and iron core gold nanoparticle (ICGNP), conjugated with the Salmonella antibody and the fluorophore, 4-Methylumbelliferyl Caprylate (4-MUCAP), used as an indicator, for its selective and sensitive detection in contaminated food products. Twenty double-blind beverage samples, spiked with Salmonella enteritidis, Staphylococcus aureus, and Escherichia coli, were prepared in sterile Eppendorf® tubes at room temperature. The gold layer and spikes of ICGNPs increased the surface areas. The ratio …