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Assemblages And Actor Networks In The Borderlands - The Apposition Of Reproductive Rights Along The Mexican-American Border, Madeleine M. Plasencia
Assemblages And Actor Networks In The Borderlands - The Apposition Of Reproductive Rights Along The Mexican-American Border, Madeleine M. Plasencia
Articles
In 1971, Sarah Weddington argued Roe v. Wade as a class action on behalf of pregnant women living in Texas, many of whom, including herself had to flee the State to obtain an abortion in Mexico. In 2021, Texas enacted S. B. 8, otherwise known as the Texas Heartbeat Act, which created a private cause of action for injunctive relief and statutory damages awards against any person assisting in and any physician accused of performing an abortion, thus reigniting the cross-border flows that historically have made Mexico a haven for runaway enslaved people and pregnant persons heading south to freedom. …
Improving The Affirmative Disclosure Of Agency Legal Materials, Bernard W. Bell, Cary Coglianese, Michael E. Herz, Margaret B. Kwoka, Orly Lobel
Improving The Affirmative Disclosure Of Agency Legal Materials, Bernard W. Bell, Cary Coglianese, Michael E. Herz, Margaret B. Kwoka, Orly Lobel
Articles
It is axiomatic that in a democratic society the law must be broadly accessible. Administrative agencies produce a plethora of materials imposing legal obligations on commercial or individual actors in the private sector. Other materials bind the agencies themselves in ways that affect the rights or interests of private parties. Still other materials provide the public with information about how agencies interpret and apply the statutes and rules they administer, or how agencies seek to deploy their discretion or take other actions that can affect private individuals or organizations. This Article focuses on improving the public availability of all of …
Situating The Modern Public Trust Doctrine In Trust Law: The Duty Of Loyalty And The Case For Bifurcated, De Novo Judicial Review, Edward A. Zelinsky
Situating The Modern Public Trust Doctrine In Trust Law: The Duty Of Loyalty And The Case For Bifurcated, De Novo Judicial Review, Edward A. Zelinsky
Articles
This article situates the modern public trust doctrine (PTD) in contemporary trust law. Grounding the PTD in trust law leads to two important corollaries. First, the PTD planted in trust law imposes upon government actors and agencies trust law’s fiduciary duty of loyalty. In the context of the PTD, that duty of loyalty runs to the public as the beneficiary of the PTD. Second, faced with plausible claims that this fiduciary duty of loyalty to the public has been violated, courts should apply trust law’s de novo standard of review to those administrative and legislative decisions alleged to impair public …
Gene Expression Of Kynurenine Pathway Enzymes In Depression And Following Electroconvulsive Therapy, Karen M. Ryan, Myles Corrigan, Therese M. Murphy, Declan M. Mcloughlin, Andrew Harkin
Gene Expression Of Kynurenine Pathway Enzymes In Depression And Following Electroconvulsive Therapy, Karen M. Ryan, Myles Corrigan, Therese M. Murphy, Declan M. Mcloughlin, Andrew Harkin
Articles
Objective: This study aimed to investigate changes in mRNA expression of the kynurenine pathway (KP) enzymes tryptophan 2, 3-dioxygenase (TDO), indoleamine 2, 3-dioxygenase 1 and 2 (IDO1, IDO2), kynurenine aminotransferase 1 and 2 (KAT1, KAT2), kynurenine monooxygenase (KMO) and kynureninase (KYNU) in medicated patients with depression (n = 74) compared to age- and sex-matched healthy controls (n = 55) and in patients with depression after electroconvulsive therapy (ECT). Associations with mood score (24-item Hamilton Depression Rating Scale, HAM-D24), plasma KP metabolites and selected glucocorticoid and inflammatory immune markers known to regulate KP enzyme expression were also explored. Methods: HAM-D24 was …
Valuing Social Data, Amanda Parsons, Salome Viljoen
Valuing Social Data, Amanda Parsons, Salome Viljoen
Articles
Social data production—accumulating, processing, and using large volumes of data about people—is a unique form of value creation that characterizes the digital economy. Social data production also presents critical challenges for the legal regimes that encounter it. This Article provides scholars and policymakers with the tools to comprehend this new form of value creation through two descriptive contributions. First, it presents a theoretical account of social data, a mode of production that is cultivated and exploited for two distinct (albeit related) forms of value: prediction value and exchange value. Second, it creates and defends a taxonomy of three “scripts” that …
Tying Law For The Digital Age, Daniel A. Crane
Tying Law For The Digital Age, Daniel A. Crane
Articles
Tying arrangements, a central concern of antitrust policy since the early days of the Sherman and Clayton Acts, have come into renewed focus with re-spect to the practices of dominant technology companies. Unfortunately, tying law’s doctrinal structure is a self-contradictory and incoherent wreck. A con-ventional view holds that this mess is due to errant Supreme Court precedents, never fully corrected, that expressed hostility to tying based on faulty economic understanding. That is only part of the story. Examination of tying law’s origins and development shows that tying doctrine was built on a now-dated paradigm of what constitutes a tying arrangement. …
Generalised Zero-Shot Learning For Action Recognition Fusing Text And Image Gans, Kaiqiang Huang, Susan Mckeever, Luis Miralles-Pechuán
Generalised Zero-Shot Learning For Action Recognition Fusing Text And Image Gans, Kaiqiang Huang, Susan Mckeever, Luis Miralles-Pechuán
Articles
Generalized Zero-Shot Action Recognition (GZSAR) is geared towards recognizing classes that the model has not been trained on, while still maintaining robust performance on the familiar, trained classes. This approach mitigates the need for an extensive amount of labeled training data and enhances the efficient utilization of available datasets. The main contribution of this paper is a novel approach for GZSAR that combines the power of two Generative Adversarial Networks (GANs). One GAN is responsible for generating embeddings from visual representations, while the other GAN focuses on generating embeddings from textual representations. These generated embeddings are fused, with the selection …
An Image Processing Approach For Real-Time Safety Assessment Of Autonomous Drone Delivery, Assem A. Abdelhak, Dan Moss, Alan Hicks, Susan Mckeever
An Image Processing Approach For Real-Time Safety Assessment Of Autonomous Drone Delivery, Assem A. Abdelhak, Dan Moss, Alan Hicks, Susan Mckeever
Articles
The aim of producing self-driving drones has driven many researchers to automate various drone driving functions, such as take-off, navigation, and landing. However, despite the emergence of delivery as one of the most important uses of autonomous drones, there is still no automatic way to verify the safety of the delivery stage. One of the primary steps in the delivery operation is to ensure that the dropping zone is a safe area on arrival and during the dropping process. This paper proposes an image-processing-based classification approach for the delivery drone dropping process at a predefined destination. It employs live streaming …
Toward Circular Economy: Potentials Of Spent Coffee Grounds In Bioproducts And Chemical Production, Hisham Ahmed, Rasaq S. Abolore, Swarna Jaiswal, Amit K. Jaiswal
Toward Circular Economy: Potentials Of Spent Coffee Grounds In Bioproducts And Chemical Production, Hisham Ahmed, Rasaq S. Abolore, Swarna Jaiswal, Amit K. Jaiswal
Articles
With growing concern over environmental sustainability and dwindling fossil resources, it is crucial to prioritise the development of alternative feedstocks to replace fossil resources. Spent coffee grounds (SCGs) are an environmental burden with an estimated six million tons being generated on a wet basis annually, globally. SCGs are rich in cellulose, lignin, protein, lipids, polyphenols and other bioactive compounds which are important raw materials for use in industries including pharmaceuticals and cosmetics. Furthermore, the energy sector has the potential to capitalize on the high calorific value of SCGs for biofuel and biogas production, offering a sustainable alternative to fossil fuels. …
Chickpea Seed Endophyte Enterobacter Sp. Mediated Yield And Nutritional Enrichment Of Chickpea For Improving Human And Livestock Health, Arpan Mukherjee, Anand Kumar Gaurav, Gowardhan Kumar Chouhan, Saurabh Singh, Ankita Sarkar, Saman Abeysinghe, Jay Prakash Verma
Chickpea Seed Endophyte Enterobacter Sp. Mediated Yield And Nutritional Enrichment Of Chickpea For Improving Human And Livestock Health, Arpan Mukherjee, Anand Kumar Gaurav, Gowardhan Kumar Chouhan, Saurabh Singh, Ankita Sarkar, Saman Abeysinghe, Jay Prakash Verma
Articles
Chickpeas (Cicer arietinum L.) are used as a good source of proteins and energy in the diets of various organisms including humans and animals. Chickpea straws can serve as an alternative option for forage for different ruminants. This research mainly focussed on screening the effects of adding beneficial chickpea seed endophytes on increasing the nutritional properties of the different edible parts of chickpea plants. Two efficient chickpea seed endophytes (Enterobacter sp. strain BHUJPCS-2 and BHUJPCS-8) were selected and applied to the chickpea seeds before sowing in the experiment conducted on clay pots. Chickpea seeds treated with both endophytes showed improved …
Vitamin K2 In Health And Disease: A Clinical Perspective, Tao Zhang, Christine O'Connor, Helen Sheridan, James W. Barlow
Vitamin K2 In Health And Disease: A Clinical Perspective, Tao Zhang, Christine O'Connor, Helen Sheridan, James W. Barlow
Articles
Vitamins are essential organic compounds that vary widely in chemical structure and are vital in small quantities for numerous biochemical and biological functions. They are critical for metabolism, growth, development and maintaining overall health. Vitamins are categorised into two groups: hydrophilic and lipophilic. Vitamin K (VK), a lipophilic vitamin, occurs naturally in two primary forms: phylloquinone (VK1), found in green leafy vegetables and algae, and Menaquinones (VK2), present in certain fermented and animal foods and widely formulated in VK supplements. This review explores the possible factors contributing to VK deficiency, including dietary influences, and discusses the pharmacological and therapeutic potential …
The Price Of Criminal Law, Russell M. Gold
The Price Of Criminal Law, Russell M. Gold
Articles
Should tax dollars pay for more criminal law, better public schools, or a new community center? Different counties will answer the question differently, but facing these tradeoffs is profoundly important to democratic governance. Nonetheless, because the criminal legal system diffuses power and hides and offioads costs, officials and voters do not have to honestly consider that question. These structural features place a hidden thumb on the scale that gives counties more criminal enforcement than they pay for. That is a problem. Too much enforcement is particularly pernicious in criminal law: Incarceration inflicts tremendous suffering, especially in poor communities of color. …
Radiobiological Applications Of Vibrational Spectroscopy: A Review Of Analyses Of Ionising Radiation Effects In Biology And Medicine, Jade F. Monaghan, Hugh J. Byrne, Fiona M. Lyng, Aidan D. Meade
Radiobiological Applications Of Vibrational Spectroscopy: A Review Of Analyses Of Ionising Radiation Effects In Biology And Medicine, Jade F. Monaghan, Hugh J. Byrne, Fiona M. Lyng, Aidan D. Meade
Articles
Vibrational spectroscopic techniques, such as Fourier transform infrared (FTIR) absorption and Raman spectroscopy (RS), offer unique and detailed biochemical fingerprints by detecting specific molecular vibrations within samples. These techniques provide profound insights into the molecular alterations induced by ionising radiation, which are both complex and multifaceted. This paper reviews the application of rapid and label-free vibrational spectroscopic methods for assessing biological radiation responses. These assessments span from early compartmentalised models such as DNA, lipid membranes, and vesicles to comprehensive evaluations in various living biological models, including tissues, cells, and organisms of diverse origins. The review also discusses future perspectives, highlighting …
Raman Spectroscopic Analysis Of Human Blood Serum Of Glaucoma Patients Supplemented With Macular Pigment Carotenoids, Joy Udensi, Ekaterina Loskutova, James Loughman, Hugh J. Byrne
Raman Spectroscopic Analysis Of Human Blood Serum Of Glaucoma Patients Supplemented With Macular Pigment Carotenoids, Joy Udensi, Ekaterina Loskutova, James Loughman, Hugh J. Byrne
Articles
As all major dietary carotenoids are contained in blood, it is a suitable substrate to evaluate their content, in vivo. Following 18-month supplementation of open-angle glaucoma patients with macula-pigment carotenoids (Lutein, Zeaxanthin and Meso-Zeaxanthin) in the European Nutrition in Glaucoma Management trial, Raman spectroscopic analysis of the carotenoid content of pre- and post-supplementation participant blood serum was carried out, to investigate the systemic impact of the supplementation regimen and explore a more direct way of quantifying this impact using routine blood tests. Using a 532 nm laser source for optimal response, a consistent increase in serum carotenoid concentration was observed …
A Business Model For Communication Design Enterprises, Con Kennedy
A Business Model For Communication Design Enterprises, Con Kennedy
Articles
Several international reports and studies indicate that the Communication Design sector has a skill deficit in entrepreneurship and business management, and a greater understanding of these topics is needed. Some authors advocate applying existing business models for design enterprises. However, the skill deficit prevails. It is worth noting that these reports discuss the entrepreneurship deficit in general terms without an explanation of the causes of this deficit or how to remedy the issue. Therefore, this paper explores the development of a Business Model specific for Design Entrepreneurs for deployment in Communication Design enterprises.A theoretical framework for a specific business model …
The Forthcoming General Election In The Republic Of Ireland: Winds Of (Left-Wing) Change Or Plus Ça Change?, Chris O'Ralaigh
The Forthcoming General Election In The Republic Of Ireland: Winds Of (Left-Wing) Change Or Plus Ça Change?, Chris O'Ralaigh
Articles
The forthcoming general election will be the most consequential electoral contest for the Republic of Ireland in a century. The polity is situated in truly novel territory with the potential for an historic first: the incoming of a Sinn Féin-led, left-wing government. Any such government would portend change in the North of Ireland, symbolising a critical juncture on the path towards the ending of partition. Analysing electoral and ideological shifts across the post-2008 period, this article examines the immediate prospects for the coming to power of a left-wing government and an historic first in Irish politics.
A Rapid On-Site Loop-Mediated Isothermal Amplification Technology As An Early Warning System For The Detection Of Shiga Toxin-Producing Escherichia Coli In Water, Zina Alfahl, Sean Biggins, Owen Higgins, Alexandra Chueiri, Terry J. Smith, Dearbháile Morris, Jean O'Dwyer, Paul D. Hynds, Liam P. Burke, Louise O'Connor
A Rapid On-Site Loop-Mediated Isothermal Amplification Technology As An Early Warning System For The Detection Of Shiga Toxin-Producing Escherichia Coli In Water, Zina Alfahl, Sean Biggins, Owen Higgins, Alexandra Chueiri, Terry J. Smith, Dearbháile Morris, Jean O'Dwyer, Paul D. Hynds, Liam P. Burke, Louise O'Connor
Articles
Shiga toxin-producing Escherichia coli (STEC) is an important waterborne pathogen capable of causing serious gastrointestinal infections with potentially fatal complications, including haemolytic–uremic syndrome. All STEC serogroups harbour genes that encode at least one Shiga toxin (stx1 and/or stx2), which constitute the primary virulence factors of STEC. Loop-mediated isothermal amplification (LAMP) enables rapid real-time pathogen detection with a high degree of specificity and sensitivity. The aim of this study was to develop and validate an on-site portable diagnostics workstation employing LAMP technology to permit rapid real-time STEC detection in environmental water samples. Water samples (n=28) were collected from groundwater wells (n=13), …
Mycotoxin Detection Through Colorimetric Immunoprobing With Gold Nanoparticle Antibody Conjugates, Vinayak Sharma, Bilal Javed, Hugh J. Byrne, Furong Tian
Mycotoxin Detection Through Colorimetric Immunoprobing With Gold Nanoparticle Antibody Conjugates, Vinayak Sharma, Bilal Javed, Hugh J. Byrne, Furong Tian
Articles
Driven by their exceptional optical characteristics, robust chemical stability, and facile bioconjugation, gold nanoparticles (AuNPs) have emerged as a preferred material for detection and biosensing applications in scientific research. This study involves the development of a simple, rapid, and cost-effective colorimetric immuno-sensing probe to detect aflatoxin B1 and zearalenone using AuNP antibody (AuNP-mAb) conjugates. Anti-toxin antibodies were attached to the AuNPs by using the physical adsorption method. The colorimetric immunosensor developed operates on the principle that the optical properties of the AuNP are very sensitive to aggregation, which can be induced by a critical high salt concentration. Although the presence …
Sex- And Gender-Specific Considerations In Mycotoxin Screening: Assessing Differential Exposure, Health Impacts, And Mitigation Strategies, Gayathree Thenuwara, Bilal Javed, Singh Baljit, Hugh J. Byrne, Furong Tian
Sex- And Gender-Specific Considerations In Mycotoxin Screening: Assessing Differential Exposure, Health Impacts, And Mitigation Strategies, Gayathree Thenuwara, Bilal Javed, Singh Baljit, Hugh J. Byrne, Furong Tian
Articles
Mycotoxins, toxic secondary metabolites produced by fungi, present significant health risks through contaminated food and feed. Despite broad documentation of their general impacts, emerging research highlights the requirement of addressing both sex- and gender-specific differences in the risk of exposure, susceptibility, and health outcomes in mycotoxin screening and mitigation strategies. Distinct biological (sex-based) and sociocultural (gender-based) factors can influence the risk of mycotoxin exposure and subsequent health impacts; women may for example exhibit specific exposures to certain mycotoxins due to physiological and hormonal differences, with increased risks during critical life stages such as pregnancy and lactation. Conversely, men may demonstrate …
Biosensor-Enhanced Organ-On-A-Chip Models For Investigating Glioblastoma Tumor Microenvironment Dynamics, Gayathree Thenuwara, Bilal Javed, Baljit Singh, Furong Tian
Biosensor-Enhanced Organ-On-A-Chip Models For Investigating Glioblastoma Tumor Microenvironment Dynamics, Gayathree Thenuwara, Bilal Javed, Baljit Singh, Furong Tian
Articles
Glioblastoma, an aggressive primary brain tumor, poses a significant challenge owing to its dynamic and intricate tumor microenvironment. This review investigates the innovative integration of biosensor-enhanced organ-on-a-chip (OOC) models as a novel strategy for an in-depth exploration of glioblastoma tumor microenvironment dynamics. In recent years, the transformative approach of incorporating biosensors into OOC platforms has enabled real-time monitoring and analysis of cellular behaviors within a controlled microenvironment. Conventional in vitro and in vivo models exhibit inherent limitations in accurately replicating the complex nature of glioblastoma progression. This review addresses the existing research gap by pioneering the integration of biosensor-enhanced OOC …
Characterization Of Spent Grain From Irish Whiskey Distilleries For Biorefinery Feedstock Potential To Produce High-Value Chemicals And Biopolymers, Rasaq S. Abolore, Dileswar Pradhan, Swarna Jaiswal, Amit K. Jaiswal
Characterization Of Spent Grain From Irish Whiskey Distilleries For Biorefinery Feedstock Potential To Produce High-Value Chemicals And Biopolymers, Rasaq S. Abolore, Dileswar Pradhan, Swarna Jaiswal, Amit K. Jaiswal
Articles
Distiller's spent grain (DSG) is a byproduct generated in large quantities during the mashing process, particularly in the production of alcoholic beverages such as whiskey. This study aimed to characterize DSG from nine different distilleries as a potential biorefinery feedstock for the synthesis of high-value bioproducts. Key components, including protein (12.38–26.32%), cellulose (11.75–32.75%), hemicellulose (6.97–19.47%), lignin (8.44–15.71%), and total phenolics (1.42 to 3.97 mg GAE/g), were analyzed to evaluate their variability and suitability for industrial applications. The results reveal that DSG composition varies significantly across distilleries due to differences in processing techniques, even though the starting grain composition had minimal …
A Comprehensive Review Of Food Safety Culture In The Food Industry: Leadership, Organizational Commitment, And Multicultural Dynamics, Ashwini Sadashiv Pai, Swarna Jaiswal, Amit K. Jaiswal
A Comprehensive Review Of Food Safety Culture In The Food Industry: Leadership, Organizational Commitment, And Multicultural Dynamics, Ashwini Sadashiv Pai, Swarna Jaiswal, Amit K. Jaiswal
Articles
Food safety culture (FSC) has transitioned from a narrow compliance-based concept to a comprehensive organisational value that is essential for ensuring food safety. This review explores the pivotal roles of leadership, organisational commitment, and cultural diversity in shaping an effective FSC. It highlights how leadership style, particularly transformational leadership, can enhance employee engagement and foster a proactive safety culture. Additionally, the impact of national and organisational cultures on FSC is analysed, emphasising the challenges posed by a multicultural workforce in standardising food safety practices. This article also provides a comparative analysis of FSC across various sectors, such as meat and …
Agro-Food Waste Valorization For Sustainable Bio-Based Packaging, Luana De S.C. Carnaval, Amit K. Jaiswal, Swarna Jaiswal
Agro-Food Waste Valorization For Sustainable Bio-Based Packaging, Luana De S.C. Carnaval, Amit K. Jaiswal, Swarna Jaiswal
Articles
In recent years, the increase in the generation of agro-food processing waste, coupled with uncontrolled disposal and inefficient recovery methods, has raised concerns among society, industries, and the research community. This issue is compounded by the accumulation of conventional synthetic packaging. Owing to their significant environmental and economic impacts, the development of sustainable, biocompatible, and biodegradable materials has become an urgent target. In this context, research efforts have been directed toward developing new packaging materials based on renewable sources, such as agro-food waste, contributing to the circular economy concept. However, despite significant advances, novel agro-food-waste-based packaging solutions still largely remain …
A Food-Exchange Model For Achieving The Recommended Dietary Intakes For Saturated Fat In Irish Children: Analysis From The Cross-Sectional National Children's Food Survey Ii, Aileen O'Connor, Maria Buffini, Anne P. Nugent, Laura Kehoe, Albert Flynn, Janette Walton, John Kearney, Breige Mcnulty
A Food-Exchange Model For Achieving The Recommended Dietary Intakes For Saturated Fat In Irish Children: Analysis From The Cross-Sectional National Children's Food Survey Ii, Aileen O'Connor, Maria Buffini, Anne P. Nugent, Laura Kehoe, Albert Flynn, Janette Walton, John Kearney, Breige Mcnulty
Articles
Objective: To identify the main foods determining saturated fatty acid (SFA) intakes and model the impact of food exchanges to improve compliance with dietary fat recommendations in Irish children. Design: Estimated food and nutrient intakes were obtained from a cross-sectional study, the National Children's Food Survey II. Participants were categorised into low, medium, and high SFA consumers, and the contribution of food categories to SFA intakes were compared. A food-exchange model was developed, whereby a selected range of high SFA foods were exchanged with lower SFA or unsaturated fat alternatives. Setting: Participants were randomly selected from primary schools throughout the …
The American Antimonopoly Tradition: Origins, Contradictions, Transformations, Daniel A. Crane
The American Antimonopoly Tradition: Origins, Contradictions, Transformations, Daniel A. Crane
Articles
Proponents of antitrust reform argue for the rediscovery of an American antimonopoly tradition that predated the Sherman Act by centuries and suggests the reimagination of a more robust contemporary policy against concentrated economic power. But historically there have been a number of distinct and often contradictory strands of American antimonopoly. The American colanists inherited a weak, recent, and largely invented antimonopoly common law tradition focused on exclusive grants of privilege from the crown. In the nineteenth century, antimonopoly became a generative and ubiquitous concept in state legislatures and courts, but one with multiple, inconsistent meanings that evolved in the decades …
Founder Worship, Effective Altruism, And Corporate Governance, Jennifer S. Fan, Xuan-Thao Nguyen
Founder Worship, Effective Altruism, And Corporate Governance, Jennifer S. Fan, Xuan-Thao Nguyen
Articles
Founders are the heart of any startup. Oftentimes, they are given considerable latitude in managing a company, particularly if they are hailed as a visionary founder in a pathbreaking new industry. Additionally, it is assumed that underpinning their actions is the desire to do good. Unfortunately, sometimes this leads to what we term founder worship where the promise of the founder and the innovation may lead to perverse outcomes because too much control is ceded to the founder and there is a lack (or sometimes complete absence of) corporate governance. When unlimited control is coupled with "do gooderism," which in …
Synthesis Of Cationic Liposome Nanoparticles Using A Thin Film Dispersed Hydration And Extrusion Method, Alessandro Cazzolla, Julie Rose Mae Mondala, Janith Wanigasekara, Joanna Carroll, Noah Daly, Brijesh Tiwari, Alan Casey, James F. Curtin
Synthesis Of Cationic Liposome Nanoparticles Using A Thin Film Dispersed Hydration And Extrusion Method, Alessandro Cazzolla, Julie Rose Mae Mondala, Janith Wanigasekara, Joanna Carroll, Noah Daly, Brijesh Tiwari, Alan Casey, James F. Curtin
Articles
Liposome nanoparticles can carry a wide range of therapeutic molecules including small molecules and nucleic acid-based therapeutics. Potential benefits include translocation across physiological barriers, reduced systemic toxicity, and enhanced pharmacokinetic parameters such as absorption, distribution, selective release and optimal elimination kinetics. Liposome nanoparticles can be generated with a wide range of natural and synthetic lipid-based molecules that confer desirable properties depending on the desired therapeutic application Nel et al (2023), Large (2021), Elkhoury (2020). This protocol article seeks to detail the procedures involved in the production of cationic liposomes using thin-film dispersed hydration method with an estimated uniform size of …
Synergistic Cytotoxicity Effect Of Ultrasound And Plasma Microbubble In Glioblastoma 3d Tumor Sphere Model, Janith Wanigasekara, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin
Synergistic Cytotoxicity Effect Of Ultrasound And Plasma Microbubble In Glioblastoma 3d Tumor Sphere Model, Janith Wanigasekara, Patrick J. Cullen, Brijesh Tiwari, James F. Curtin
Articles
The combined application of ultrasound (US) and plasma microbubble (PMB) is a promising technology against glioblastoma (GBM). Here, we determined the effects of US and PMB (alone and combined) on U-251 MG GBM and A431 epidermoid carcinoma spheroids under different conditions. The synergistic treatment of US- and PMB-induced tumor sphere cell death in a time-, dose-, treatment frequency-, and reactive oxygen species dependent manner, while multiple treatments augmented this effect. Synergistic treatments significantly reduced three-dimensional GBM spheroid regrowth and cell proliferation while inducing cytotoxicity, spheroid shrinkage, and damage to the tumor microenvironment. PMB-induced cytotoxicity throughout the tumor sphere, likely via …
Review Of Detection Limits For Various Techniques For Bacterial Detection In Food Samples, Xinyi Zhao Nanolab Research Centre, Abhijnan Bhat, Christine O’Connor School Of Food Science And Environmental Health, James Curtin Faculty Of Engineering And Built Environment, Baljit Singh, Micra Biodiagnostics Technology Gateway And Health, Engineering & Materials Sciences (Hems) Research Hub, Furong Tian Nanolab Research Centre
Review Of Detection Limits For Various Techniques For Bacterial Detection In Food Samples, Xinyi Zhao Nanolab Research Centre, Abhijnan Bhat, Christine O’Connor School Of Food Science And Environmental Health, James Curtin Faculty Of Engineering And Built Environment, Baljit Singh, Micra Biodiagnostics Technology Gateway And Health, Engineering & Materials Sciences (Hems) Research Hub, Furong Tian Nanolab Research Centre
Articles
Foodborne illnesses can be infectious and dangerous, and most of them are caused by bacteria. Some common food-related bacteria species exist widely in nature and pose a serious threat to both humans and animals; they can cause poisoning, diseases, disabilities and even death. Rapid, reliable and cost-effective methods for bacterial detection are of paramount importance in food safety and environmental monitoring. Polymerase chain reaction (PCR), lateral flow immunochromatographic assay (LFIA) and electrochemical methods have been widely used in food safety and environmental monitoring. In this paper, the recent developments (2013–2023) covering PCR, LFIA and electrochemical methods for various bacterial species …
Addressing The Complexity Of Spatial Teaching: A Narrative Review Of Barriers And Enablers, Ergi Bufasi, Ting Jun Lin, Ursa Benedicic, Marten Westerhof, Rohit Mishra, Dace Namsone, Inese Dudareva, Sheryl Sorby, Lena Gumaelius, Remke M. Klapwijk, Jeroen Spandaw, Brian Bowe, Colm O'Kane, Gavin Duffy, Marianna Pagkratidou, Jeffrey Buckley
Addressing The Complexity Of Spatial Teaching: A Narrative Review Of Barriers And Enablers, Ergi Bufasi, Ting Jun Lin, Ursa Benedicic, Marten Westerhof, Rohit Mishra, Dace Namsone, Inese Dudareva, Sheryl Sorby, Lena Gumaelius, Remke M. Klapwijk, Jeroen Spandaw, Brian Bowe, Colm O'Kane, Gavin Duffy, Marianna Pagkratidou, Jeffrey Buckley
Articles
Extensive research has established that spatial ability is a crucial factor for achieving success in Science, Technology, Engineering, and Mathematics (STEM). However, challenges that educators encounter while teaching spatial skills remain uncertain. The purpose of this study is to develop a research framework that examines the interrelationships, barriers, and enablers amongst various educational components, including schools, teachers, students, classrooms, and training programs, that are encountered when teaching for spatial ability development. A thorough examination of international research, in combination with a detailed review of the primary Science and Mathematics curricula in Ireland, Latvia, Sweden, and the Netherlands, is undertaken to …