Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

All ETDs from UAB

Discipline
Keyword
Publication Year

Articles 1291 - 1320 of 3685

Full-Text Articles in Entire DC Network

Targeted Delivery Of Osteoinductive Peptides To Bone Graft Utilizing A Calcium Binding Domain To Enhance The Regenerative Potential, Jennifer Leigh Bain Jan 2014

Targeted Delivery Of Osteoinductive Peptides To Bone Graft Utilizing A Calcium Binding Domain To Enhance The Regenerative Potential, Jennifer Leigh Bain

All ETDs from UAB

Bone grafting procedures are common practice. Autogenous bone is considered optimal, however, complications associated with bone harvesting often lead clinicians to use off-the-shelf materials that have limited osteoinductivity. Alternatively, bioactive factors passively adsorbed onto various carriers are available. These materials, while effective, are expensive to produce, require supraphysiological doses, and have adverse side effects due to dissemination from the graft site. This dissertation aims to reintroduce osteoinductive factors to bone grafts to enhance regenerative capacity. Specifically, we utilized negatively-charged calcium-binding domains (polyglutamate) to anchor two osteoinductive peptides bone graft materials including an allograft, xenograft, alloplast, and bone cement. The peptides …

Go to article

Internet Use And Mental Health/Well-Being In Old Age: Exploring The Roles Of Social Integration And Social Support, Ronald William Berkowsky Jan 2014

Internet Use And Mental Health/Well-Being In Old Age: Exploring The Roles Of Social Integration And Social Support, Ronald William Berkowsky

All ETDs from UAB

The escalating pressures put on the US healthcare system, due in part to the growing needs of the expanding older adult population, has motivated research dedicated to more fully understanding the mental health and mental well-being needs of this population and ways to address these needs and alleviate the pressure on the healthcare system. An increasing area of interest is in examining the role information and communication technologies (ICTs), such as Internet-connected computers and smartphones, in the health of older adults. Research has shown that ICTs can successfully be used to help treat, manage, and cope with mental health/well-being issues, …

Go to article

Ap2 Clock Mutant Mice: Baseline Characteristics And Novel Responses To A Lipopolysaccharide Challenge, Tana Birky Jan 2014

Ap2 Clock Mutant Mice: Baseline Characteristics And Novel Responses To A Lipopolysaccharide Challenge, Tana Birky

All ETDs from UAB

Circadian rhythms are the daily biological changes present within most organisms that occur in a predictable, approximately 24 hour pattern, even in the absence of external stimuli. These rhythms occur both at a global and cellular level, and although the molecular mechanics are highly conserved, their functions may vary depending on the tissues in which they are expressed. These functions include various aspects of metabolic processes such as satiety signaling and cellular proliferation. In order to explore the specific functions of circadian rhythms within adipocytes, a mouse model with Clock disruption driven by the fatty acid-binding protein 2 (aP2) promoter …

Go to article

Predictors Of Outcomes In Patients With Ventricular Assist Devices, Amelia Katharine Boehme Jan 2014

Predictors Of Outcomes In Patients With Ventricular Assist Devices, Amelia Katharine Boehme

All ETDs from UAB

Ventricular assist devices (VAD) are used as a bridge to transplant and to increase the quality of life in advanced heart failure patients. The use of the VAD is not without risks itself, with an increased risk of thromboembolism, hemorrhage and death. Therefore, we aimed to (1) evaluate predictors of thromboembolism; (2) design a score to predict hemorrhages in VAD patients; and (3) evaluate the change in kidney function post-VAD implant and to investigate the relationship between kidney function and mortality in VAD patients using data collected from the University of Alabama at Birmingham Mechanical Circulatory Support Clinic. Over the …

Go to article

Promoting Worksite Stair Use By Launching The "Stepping Up" Campaign, Lynne A. Obiaka Jan 2014

Promoting Worksite Stair Use By Launching The "Stepping Up" Campaign, Lynne A. Obiaka

All ETDs from UAB

Background: Obesity and overweight contribute to worksite absenteeism and decreased productivity. Encouraging employees to frequent the stairs is one approach towards increasing worksite physical activity. Methods: An explanatory, mixed methods research design was used to explore the impact of a health communications campaign entitled "Stepping Up" on worksite stair use in health department employees. The campaign included octagonal shaped posters similar to traffic signs, email prompts and printed materials. A pretest and posttest were administered before and after the intervention to assess stair use frequencies and identify predictors. A Wilcoxon signed-rank test for related samples, Spearman correlations and multiple rank …

Go to article

Effects Of Early Life Exposure To Methylmercury On Predator Response In Daphnia Pulex, Megan Lisa Steed Jan 2014

Effects Of Early Life Exposure To Methylmercury On Predator Response In Daphnia Pulex, Megan Lisa Steed

All ETDs from UAB

Knowledge of the health effects of toxic chemicals is largely based on single chemical models rather than a multi-factor model, which more accurately captures realworld exposures. This study investigated how methylmercury affects Daphnia pulex in the presence of predatory stress chemical. A kairomone is an infochemical released by an animal that can be detected by another animal. Daphnia pulex detects kairomone released by Danio rerio resulting in the induction of morphological and life history changes. Danio rerio were kept in COMBO media for 24 hours at a density of 2 fish per liter. Daphnids were then housed in kairomone-containing COMBO …

Go to article

Translocation Of Shed Syndecan-1 To The Nucleus: A Novel Mechanism Of Tumor-Host Crosstalk, Mark Stewart Jan 2014

Translocation Of Shed Syndecan-1 To The Nucleus: A Novel Mechanism Of Tumor-Host Crosstalk, Mark Stewart

All ETDs from UAB

Multiple myeloma is a hematological malignancy of plasma cells that disseminates throughout the body. Crosstalk between myeloma and host cells is critical to the establishment of a microenvironment conducive to tumor growth and progression. An important mediator of this crosstalk is syndecan-1, a heparan sulfate proteoglycan. Syndecan-1 is proteolytically shed from the surface of myeloma cells and is abundant in the bone marrow microenvironment and serum of myeloma patients. Shed syndecan-1 facilitates tumor-host crosstalk within the microenvironment to drive tumor growth, angiogenesis, and metastasis. We now report for the first time that shed syndecan-1 can be taken up by a …

Go to article

The Conservation Of The Western Pacific Leatherback Sea Turtle (Dermochelys Coriacea) At Bird's Head Peninsula, Papua Barat, Indonesia, Ricardo F. Tapilatu Jan 2014

The Conservation Of The Western Pacific Leatherback Sea Turtle (Dermochelys Coriacea) At Bird's Head Peninsula, Papua Barat, Indonesia, Ricardo F. Tapilatu

All ETDs from UAB

Leatherbacks declined significantly worldwide during the 20th century and continue to decline in the Pacific and Indian oceans. In the Pacific Ocean, nesting numbers on beaches in Malaysia and the Pacific coast of Mexico and Costa Rica have collapsed. The nesting beaches at Bird's Head Papua Barat, Indonesia, represent the last stronghold for leatherback nesting in the western Pacific. The studies in this dissertation provide basic information that is critical to our understanding of the biology, ecology, and conservation of the western Pacific leatherback. (1) Year-round nesting surveys were conducted from 2005 to 2011 at both Jamursba Medi and Wermon …

Go to article

Statistical Analysis In Genomic Studies, Guodong Wu Jan 2014

Statistical Analysis In Genomic Studies, Guodong Wu

All ETDs from UAB

Next-generation sequencing (NGS) technologies reveal unprecedented insights about genome, transcriptome, and epigenome. However, existing quantification and statistical methods are not well prepared for the coming deluge of NGS data. In this dissertation, we propose to develop powerful new statistical methods in three aspects. First, we propose a Hidden Markov Model (HMM) in Bayesian framework to quantify methylation levels at base-pair resolution by NGS. Second, in the context of exome-based studies, we develop a general simulation framework that distributes total genetic effects hierarchically into pathways, genes, and individual variants, allowing the extensive evaluation of existing pathway-based methods. Finally, we develop a …

Go to article

Usp16 And Histone H2a Deubiquitination In Mouse Embryonic Stem Cell Function, Wei Yang Jan 2014

Usp16 And Histone H2a Deubiquitination In Mouse Embryonic Stem Cell Function, Wei Yang

All ETDs from UAB

In eukaryotic cells, genomic DNA is packaged into a chromatin structure by association with histone and non-histone proteins. Posttranslational modifications of histones play important roles in the regulation of chromatin structure and function. Ubiquitination of histone H2A (ubH2A) represents a predominate modification, occurring on ~10% of total cellular H2A. While H2A ubiquitination is primarily conferred by Polycomb Repressive Complex 1 (PRC1), H2A deubiquitination has been attributed to multiple H2A deubiquitinases. Our laboratory previously reported the purification and functional characterization of a H2A-specific deubiquitinase, USP16 (initially named as Ubp-M) in human cells. However, whether USP16 represents a general and important regulator …

Go to article

The Roles Of Mammalian Tribbles Homolog 3 (Trib3) In Coordinating Energy Metabolism And Development Of Insulin Resistance, Wei Zhang Jan 2014

The Roles Of Mammalian Tribbles Homolog 3 (Trib3) In Coordinating Energy Metabolism And Development Of Insulin Resistance, Wei Zhang

All ETDs from UAB

Insulin resistance in diabetics comprises of a reversible component treatable with intensive glycemic control and a non-reversible component present in pre-diabetes that may lead to the development of overt diabetes. The reversible component is induced and exacerbated by hyperglycemia in both uncontrolled type 1 and type 2 diabetes, a process known as glucose-induced insulin resistance (GIIR) or glucose toxicity. The tribbles homolog 3 (TRIB3) has been identified as a pseudokinase that inhibits Akt activity by physically blocking its phosphorylation site. Expression of TRIB3 has been associated with various signals such as endoplasmic reticulum (ER) stress and nutrient availability in pancreatic …

Go to article

Multiple Human Itgam Variants Alter Mac-1, Fcgamma Receptor And Tlr Functions On Neutrophils, Yebin Zhou Jan 2014

Multiple Human Itgam Variants Alter Mac-1, Fcgamma Receptor And Tlr Functions On Neutrophils, Yebin Zhou

All ETDs from UAB

Multiple studies have demonstrated that single-nucleotide polymorphisms (SNPs) in the ITGAM locus (including the non-synonymous SNPs rs1143679, rs1143678 and rs1143683) are associated with SLE. ITGAM encodes the protein CD11b, a subunit of the ß2 integrin Mac-1. The purpose of this work was to determine the effects of ITGAM genetic variation on the biological functions of neutrophil Mac-1. Neutrophils from ITGAM genotyped and sequenced healthy donors were isolated for functional studies. The phagocytic capacity of neutrophil ITGAM variants was probed with complement coated erythrocytes, serum treated zymosan, heat treated zymosan and IgG coated erythrocytes. The adhesion capacity of ITGAM variants, in …

Go to article

A Low-Power Multichannel Telemetry System For High-Speed Wireless Neural Recordings, Yang-Guo Li Jan 2014

A Low-Power Multichannel Telemetry System For High-Speed Wireless Neural Recordings, Yang-Guo Li

All ETDs from UAB

The advances in microelectronics and wireless communication are going to change our lifestyles and benefit our healthcare system in the foreseeable future. New conception named "Ubiquitous Healthcare" has been proposed. It envisions a continuous, real-time, remote monitoring on the health conditions of people through the wireless communication network. Traditional biosignal monitoring devices need wire-connections for the recording, which may cause skin rupture and body infection. The physical connections also limited the number of the integrated recording channels. A low-power implantable multichannel telemetry system which can be implanted in the body and transmit recordings wirelessly can solve the problem of the …

Go to article

Expression Of The Influenza Protein M2 During Viral Infection Inhibits Cftr Activity, James David Londino Jan 2014

Expression Of The Influenza Protein M2 During Viral Infection Inhibits Cftr Activity, James David Londino

All ETDs from UAB

The purpose of these dissertation studies was to 1) determine whether influenza infection alters CFTR activity in polarized epithelium; 2) measure CFTR expression and activity in cells co-expressing influenza M2 protein; and 3) examine the role of M2 on the alteration of CFTR during viral infection. We determined that infection of polarized primary epithelial cells with influenza decreases CFTR expression and activity. In addition, individual cells infected with influenza had decreased CFTR conductance as measured by whole-cell patch clamp. We also found that the influenza ion channel, matrix protein 2 (M2), alone reduced CFTR expression and activity. M2 is expressed …

Go to article

Interaction Between A Low-Iron Diet And Early-Life Methylmercury Exposure In Daphnia Pulex, Sherri Hudson Jan 2014

Interaction Between A Low-Iron Diet And Early-Life Methylmercury Exposure In Daphnia Pulex, Sherri Hudson

All ETDs from UAB

Methylmercury (MeHg) is a known neurotoxicant and bioaccumulates in fish, with exposure to humans in utero being of highest concern. Iron deficiency (ID) accounts for approximately 50% of anemia cases. Anemia is estimated to affect 1.62 billion people worldwide, and is particularly problematic during pregnancy and early life. Previous studies have shown that ID exacerbates toxicity associated with exposure to metals, including lead, manganese, and cadmium. The overall purpose of this thesis research is to investigate the interaction between a low-iron (Fe) diet and early-life exposure to MeHg in Daphnia pulex. I hypothesized when D. pulex are fed a low-Fe …

Go to article

Relationship Between Diabetes And Indoor Air Pollution: An Exploratory Analysis, Sandeep Mishra Jan 2014

Relationship Between Diabetes And Indoor Air Pollution: An Exploratory Analysis, Sandeep Mishra

All ETDs from UAB

India has the second highest number of people with diabetes. The high prevalence of diabetes in India cannot be explained on the basis of established risk factors like obesity. The role of air pollution in diabetes has recently received attention. Studies have indicated the possibility that air pollution generated by traffic might be associated with increased risk of diabetes. Published literature lacks studies that assess the relationship between indoor air pollution and diabetes, although indoor air pollution can lead to higher levels of pollutants in house compared to traffic pollution. The current study determined the relationship between indoor air pollution …

Go to article

Osteoblast And Odontoblast Specific Regulatory Actions Of Runx2 For The Development Of Mineralized Tissues, Mitra Darice Adhami Jan 2014

Osteoblast And Odontoblast Specific Regulatory Actions Of Runx2 For The Development Of Mineralized Tissues, Mitra Darice Adhami

All ETDs from UAB

The Runx2 transcription factor is necessary for commitment and differentiation of mesenchymal cells into the chondroblasts, osteoblasts and odontoblasts. Runx2 induces the expression of several key genes involved in mineralization of both the bone and dentin matrices. Global Runx2-null mice are completely void of mineralized tissue and do not express osteoblast markers, indicating that Runx2 is required for commitment to the osteoblast lineage. Tooth development in Runx2-null mice is arrested in the bell stage, prior to the differentiation of odontoblasts. Thus, Runx2 is essential for development of osteoblast and odontoblast lineages. However, the functional requirements of Runx2 after commitment to …

Go to article

Formaldehyde Exposure In Pregnant Women And Its Relationship To Fetal Growth, Azita Amiri Jan 2014

Formaldehyde Exposure In Pregnant Women And Its Relationship To Fetal Growth, Azita Amiri

All ETDs from UAB

Formaldehyde exposure during pregnancy has been linked to adverse pregnancy outcomes such as poor fetal growth, although few studies have examined formaldehyde exposure during pregnancy and its relationship to fetal growth. The purpose of this study was to determine the level of formaldehyde exposure during pregnancy and examine the relationship between formaldehyde exposure and fetal growth. Formaldehyde exposure was examined, using vapor monitor badge and urine formic acid, in 140 women in their second trimester of pregnancy. One time urine samples were collected during a routine prenatal visit, and women wore the vapor badges for 24 hours. Fetal growth was …

Go to article

Modulating The Cxcl12/Cxcr4 Axis In The Pulmonary Vasculature By Adenoviral Vector-Mediated Delivery Of Soluble Cxcr4 (Scxcr4): A Prophylactic Approach To The Prevention Of Cancer Metastasis To The Lung, Anand Chandrasekaran Annan Jan 2014

Modulating The Cxcl12/Cxcr4 Axis In The Pulmonary Vasculature By Adenoviral Vector-Mediated Delivery Of Soluble Cxcr4 (Scxcr4): A Prophylactic Approach To The Prevention Of Cancer Metastasis To The Lung, Anand Chandrasekaran Annan

All ETDs from UAB

The results also indicate that in situ nests were cooler than egg corral nests but still

Go to article

Fatigue Testing Of Straight And Angled Abutments In A High Torque Dental Implant System, Rana M. Atieh Jan 2014

Fatigue Testing Of Straight And Angled Abutments In A High Torque Dental Implant System, Rana M. Atieh

All ETDs from UAB

Root form dental implants are a common solution used today to replace missing teeth. However current designs still suffer from a number of limitations. Angled abutments are used for incisors, where maximum human bite forces are normally < 200N, while straight abutments are used for molars subjected to higher forces > 200 N. The aim of this study was to evaluate the mechanical performance of a novel dental implant system by fatigue testing straight and 15-degree angled abutments. It was hypothesized that the novel thread design will dissipate the load evenly throughout the implant allowing the system to withstand normal chewing forces. Implants with 4.2mm diameter were tested according to ISO 14801 in specimen …

Go to article

Francisella Tularensis Lvs Invasion Of Primary Murine Macrophages And Mtor Signaling, Michael Warren Edwards Jan 2014

Francisella Tularensis Lvs Invasion Of Primary Murine Macrophages And Mtor Signaling, Michael Warren Edwards

All ETDs from UAB

Francisella tularensis is an intracellular pathogen and the etiologic agent of tularemia. Because virulent strains cause morbidity and lethality in human, the attenuated live vaccine strain (LVS) has been used to study F. tularensis pathogenesis in murine models, since the disease in mice resembles human tularemia. Despite growing knowledge about host responses to Francisella infection, there is scarce information on the cell signaling events involved in Francisella host cell entry and in early immune re-sponses. Therefore, the purpose of this dissertation was to assess the involvement of the mammalian target of rapamycin (mTOR) in these processes. First, we evaluated the …

Go to article

The Role Of Wnt5a In Tumor Suppression And Differentiation, Stephanie Easter Jan 2014

The Role Of Wnt5a In Tumor Suppression And Differentiation, Stephanie Easter

All ETDs from UAB

TGF-beta and the Wnt signaling pathways play key roles in regulating ductal growth and branching morphogenesis in the mammary gland. Disruption to this signaling can cause deregulation of the normal mammary stem cell population and foster an environment favorable for tumorigenesis and recurrence. Recent studies show that TGF-beta up-regulates expression of the non-canonical Wnt, Wnt5a, in the mammary gland and that Wnt5a antagonizes canonical Wnt/beta-catenin signaling in mammary epithelial cells. Canonical Wnt/beta-catenin signaling has been strongly implicated in expanding the mammary stem/progenitor cell pool. Here, we test the hypothesis that Wnt5a suppresses the expansion of the mammary stem and progenitor …

Go to article

Mitochondrial Genetics And Cellular Metabolism Regulate Tumorigenicity And Metastatic Potential, Kyle Paul Feeley Jan 2014

Mitochondrial Genetics And Cellular Metabolism Regulate Tumorigenicity And Metastatic Potential, Kyle Paul Feeley

All ETDs from UAB

Current paradigms of carcinogenic risk suggest that genetic, hormonal, and environmental factors combine to influence an individual's predilection for breast cancer and related metastatic tumor formation. The genetic component, in particular, has become the focus of many emergent studies. A renewed focus on cancer metabolism and the Warburg effect has similarly cast a spotlight on the role, if any, of the mitochondrion in directing disease progression. Analysis of the direct contribution of mitochondrial DNA on tumorigenicity is made possible through the use of mitochondrial-nuclear exchange (MNX) mice in which nuclei from normal FVB mice (the background strain of the tg: …

Go to article

Exploring Novel System Biology Approaches To Understand The Molecular Mechanisms Of Immune Responses, Cassandra Camille Garbutt Jan 2014

Exploring Novel System Biology Approaches To Understand The Molecular Mechanisms Of Immune Responses, Cassandra Camille Garbutt

All ETDs from UAB

nesting behavior on sex ratios and survival of eggs and hatchlings. The results indicate

Go to article

Mitochondrial Dysfunction In Response To Neurotoxins And The Role Of Mitophagy, Samantha Giordano Jan 2014

Mitochondrial Dysfunction In Response To Neurotoxins And The Role Of Mitophagy, Samantha Giordano

All ETDs from UAB

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Two major factors in both familial and sporadic PD are mitochondrial dysfunction and insufficient autophagy. My thesis research focuses on the interplay between these activities in PD. To investigate the common and differential effects of PD-inducing neurotoxins on mitochondrial bioenergetics and their relationships to cell survival, we used an in vitro culture system, differentiated dopaminergic SH-SY5Y neuroblastoma cells. We found that the neurotoxins rotenone, 1-methyl-4- phenylyridinium (MPP+) and 6-hydroxydopamine (6-OHDA), decreased mitochondrial respiration and induced cell death in these cells. The extent and characteristics of mitochondrial dysfunction in response to …

Go to article

Therapeutic Ck2 Inhibition Attenuates Diverse Prosurvival Signaling Cascades And Decreases Cell Viability In Human Breast Cancer Cells, Gary Kenneth Gray Jan 2014

Therapeutic Ck2 Inhibition Attenuates Diverse Prosurvival Signaling Cascades And Decreases Cell Viability In Human Breast Cancer Cells, Gary Kenneth Gray

All ETDs from UAB

Breast cancer is the most common malignancy in women worldwide, and it remains a major cause of mortality, thus necessitating further advancements in treatment. In breast cancer, numerous cell signaling pathways are aberrantly activated in order to produce the myriad phenotypes associated with malignancy; such pathways include the PI3K/Akt/mTOR, NF-κB and JAK/STAT cascades. These pathways are highly interconnected, but one prominent lateral enhancer of each is the remarkably promiscuous kinase CK2. CK2 expression has been shown to be elevated in human cancer, thus implicating it in tumorigenesis through its effects on known oncogenic signaling cascades. In this study, differential aberrant …

Go to article

Regulation Of Skeletal Muscle Plasticity Using Engineered Configurations Of The Transcription Factors Myod And E12, Vladimir Grubisic Jan 2014

Regulation Of Skeletal Muscle Plasticity Using Engineered Configurations Of The Transcription Factors Myod And E12, Vladimir Grubisic

All ETDs from UAB

Skeletal muscle fibers, although terminally differentiated, can change their features, such as contraction speed and endurance, and throughout adult life in response to variety of stimuli, like exercise. This process is called plasticity and is mainly regulated by the type of nerve activity. Over the past several decades, research has shown that the properties of myofibers are also determined during muscle development. Ultimately, the change in phenotype requires a change in gene expression which is, in turn, regulated by transcription factors (TFs). Basic helix-loop-helix (bHLH) TFs regulate myogenesis and the central role belongs to the myogenic differentiation 1 (MyoD), often …

Go to article

The Role Of Human Ficolin-2 During Invasive Pneumococcal Disease, Allison Marie Brady Jan 2014

The Role Of Human Ficolin-2 During Invasive Pneumococcal Disease, Allison Marie Brady

All ETDs from UAB

Streptococcus pneumoniae (pneumococcus) is a significant human pathogen that typically resides in the nasopharynx of humans. The major virulence factor of pneumococcus is its capsular polysaccharide, of which it can express over 90 unique serotypes. However, there is great disparity in which serotypes colonize or cause disease, though the reason for these differences are not well understood. Serotype 11A is one such serotype that frequently colonizes the nasopharynx of children, but rarely causes disease. Interestingly, serotype 11E, a variant of 11A, varies only in the O-acetylation of a galactose residue in its polysaccharide repeating unit. This difference in structure is …

Go to article

Determining The Role Of Neuregulin-1 And Its Erbb Receptors In The Pathogenesis Of Malignant Peripheral Nerve Sheath Tumors, Stephanie Brosius Jan 2014

Determining The Role Of Neuregulin-1 And Its Erbb Receptors In The Pathogenesis Of Malignant Peripheral Nerve Sheath Tumors, Stephanie Brosius

All ETDs from UAB

Malignant peripheral nerve sheath tumors (MPNSTs) are the most common cause of death in patients with neurofibromatosis type-1. These aggressive, Schwann cell-derived tumors have no treatment beyond surgical resection. Developing targeted chemotherapeutics remains crucial to improving patient survival. The Schwann cell mitogen neuregulin-1 (NRG1) was shown to mediate the migration, proliferation and survival of MPNSTs. Furthermore, overexpression of NRG1 in Schwann cells (P0-GGF beta 3 mice) on an outbred C57BL/6J x SJL/J background induced the formation of neurofibromas and MPNSTs similar to human disease, yet these mice have intact neurofibromin. To determine if NRG1 acts within the same signaling cascade …

Go to article

Cd5-Dependent Ck2 Activation Is Critical For The Maintenance Of B-1a B Cells, Kevin S. Cashman Jan 2014

Cd5-Dependent Ck2 Activation Is Critical For The Maintenance Of B-1a B Cells, Kevin S. Cashman

All ETDs from UAB

CD5 has classically been shown to act as a negative regulator of antigen receptor signaling, however recent evidence has discerned that the CD5 molecule contains a previously undefined cytoplasmic domain which constitutively binds inactive CK2 and facilitates its activation through CD5 ligation. With the development of a mouse model which contains a micro-deletion knock-in form of CD5 which lacks the amino acids necessary to facilitate this CD5-CK2 interaction, it is now understood that CD5 plays a more significant role in cellular physiology than previously appreciated. T cells from this mouse model show increased AICD and dysregulation in T helper subset …

Go to article

First Prev Next Last